diff --git a/src/bootstrap/test.rs b/src/bootstrap/test.rs
index c552f607960b4..a443b7b5863e5 100644
--- a/src/bootstrap/test.rs
+++ b/src/bootstrap/test.rs
@@ -1268,11 +1268,11 @@ impl Step for Compiletest {
         builder.add_rust_test_threads(&mut cmd);
 
         if builder.config.sanitizers {
-            cmd.env("SANITIZER_SUPPORT", "1");
+            cmd.env("RUSTC_SANITIZER_SUPPORT", "1");
         }
 
         if builder.config.profiler {
-            cmd.env("PROFILER_SUPPORT", "1");
+            cmd.env("RUSTC_PROFILER_SUPPORT", "1");
         }
 
         cmd.env("RUST_TEST_TMPDIR", builder.out.join("tmp"));
diff --git a/src/test/codegen/pgo-instrumentation.rs b/src/test/codegen/pgo-instrumentation.rs
new file mode 100644
index 0000000000000..8493ef565d888
--- /dev/null
+++ b/src/test/codegen/pgo-instrumentation.rs
@@ -0,0 +1,20 @@
+// Test that `-Zpgo-gen` creates expected instrumentation artifacts in LLVM IR.
+
+// needs-profiler-support
+// compile-flags: -Z pgo-gen -Ccodegen-units=1
+
+// CHECK: @__llvm_profile_raw_version =
+// CHECK: @__profc_{{.*}}pgo_instrumentation{{.*}}some_function{{.*}} = private global
+// CHECK: @__profd_{{.*}}pgo_instrumentation{{.*}}some_function{{.*}} = private global
+// CHECK: @__profc_{{.*}}pgo_instrumentation{{.*}}main{{.*}} = private global
+// CHECK: @__profd_{{.*}}pgo_instrumentation{{.*}}main{{.*}} = private global
+// CHECK: @__llvm_profile_filename = {{.*}}"default_%m.profraw\00"{{.*}}
+
+#[inline(never)]
+fn some_function() {
+
+}
+
+fn main() {
+    some_function();
+}
diff --git a/src/test/run-make-fulldeps/pgo-gen-lto/Makefile b/src/test/run-make-fulldeps/pgo-gen-lto/Makefile
index 7c19961b1e420..48181bcbdc6d3 100644
--- a/src/test/run-make-fulldeps/pgo-gen-lto/Makefile
+++ b/src/test/run-make-fulldeps/pgo-gen-lto/Makefile
@@ -1,8 +1,8 @@
+# needs-profiler-support
+
 -include ../tools.mk
 
 all:
-ifeq ($(PROFILER_SUPPORT),1)
 	$(RUSTC) -Copt-level=3 -Clto=fat -Z pgo-gen="$(TMPDIR)" test.rs
 	$(call RUN,test) || exit 1
 	[ -e "$(TMPDIR)"/default_*.profraw ] || (echo "No .profraw file"; exit 1)
-endif
diff --git a/src/test/run-make-fulldeps/pgo-gen-no-imp-symbols/Makefile b/src/test/run-make-fulldeps/pgo-gen-no-imp-symbols/Makefile
index dc52e91317a5a..20977edb88e87 100644
--- a/src/test/run-make-fulldeps/pgo-gen-no-imp-symbols/Makefile
+++ b/src/test/run-make-fulldeps/pgo-gen-no-imp-symbols/Makefile
@@ -1,11 +1,11 @@
+# needs-profiler-support
+
 -include ../tools.mk
 
 all:
-ifeq ($(PROFILER_SUPPORT),1)
-	$(RUSTC) -O -Ccodegen-units=1 -Z pgo-gen="$(TMPDIR)/test.profraw" --emit=llvm-ir test.rs
+	$(RUSTC) -O -Ccodegen-units=1 -Z pgo-gen="$(TMPDIR)" --emit=llvm-ir test.rs
 	# We expect symbols starting with "__llvm_profile_".
 	$(CGREP) "__llvm_profile_" < $(TMPDIR)/test.ll
 	# We do NOT expect the "__imp_" version of these symbols.
 	$(CGREP) -v "__imp___llvm_profile_" < $(TMPDIR)/test.ll # 64 bit
 	$(CGREP) -v "__imp____llvm_profile_" < $(TMPDIR)/test.ll # 32 bit
-endif
diff --git a/src/test/run-make-fulldeps/pgo-gen/Makefile b/src/test/run-make-fulldeps/pgo-gen/Makefile
index 0469c4443d85a..ce44c10a7c2d2 100644
--- a/src/test/run-make-fulldeps/pgo-gen/Makefile
+++ b/src/test/run-make-fulldeps/pgo-gen/Makefile
@@ -1,8 +1,8 @@
+# needs-profiler-support
+
 -include ../tools.mk
 
 all:
-ifeq ($(PROFILER_SUPPORT),1)
 	$(RUSTC) -g -Z pgo-gen="$(TMPDIR)" test.rs
 	$(call RUN,test) || exit 1
 	[ -e "$(TMPDIR)"/default_*.profraw ] || (echo "No .profraw file"; exit 1)
-endif
diff --git a/src/test/run-make-fulldeps/profile/Makefile b/src/test/run-make-fulldeps/profile/Makefile
index 7300bfc955363..c12712590e48f 100644
--- a/src/test/run-make-fulldeps/profile/Makefile
+++ b/src/test/run-make-fulldeps/profile/Makefile
@@ -1,9 +1,9 @@
+# needs-profiler-support
+
 -include ../tools.mk
 
 all:
-ifeq ($(PROFILER_SUPPORT),1)
 	$(RUSTC) -g -Z profile test.rs
 	$(call RUN,test) || exit 1
 	[ -e "$(TMPDIR)/test.gcno" ] || (echo "No .gcno file"; exit 1)
 	[ -e "$(TMPDIR)/test.gcda" ] || (echo "No .gcda file"; exit 1)
-endif
diff --git a/src/test/run-make-fulldeps/sanitizer-address/Makefile b/src/test/run-make-fulldeps/sanitizer-address/Makefile
index 207615bfbd5c6..51d8a4a947adc 100644
--- a/src/test/run-make-fulldeps/sanitizer-address/Makefile
+++ b/src/test/run-make-fulldeps/sanitizer-address/Makefile
@@ -1,3 +1,5 @@
+# needs-sanitizer-support
+
 -include ../tools.mk
 
 LOG := $(TMPDIR)/log.txt
@@ -5,11 +7,9 @@ LOG := $(TMPDIR)/log.txt
 # NOTE the address sanitizer only supports x86_64 linux and macOS
 
 ifeq ($(TARGET),x86_64-apple-darwin)
-ASAN_SUPPORT=$(SANITIZER_SUPPORT)
 EXTRA_RUSTFLAG=-C rpath
 else
 ifeq ($(TARGET),x86_64-unknown-linux-gnu)
-ASAN_SUPPORT=$(SANITIZER_SUPPORT)
 
 # Apparently there are very specific Linux kernels, notably the one that's
 # currently on Travis CI, which contain a buggy commit that triggers failures in
@@ -23,7 +23,5 @@ endif
 endif
 
 all:
-ifeq ($(ASAN_SUPPORT),1)
 	$(RUSTC) -g -Z sanitizer=address -Z print-link-args $(EXTRA_RUSTFLAG) overflow.rs | $(CGREP) librustc_asan
 	$(TMPDIR)/overflow 2>&1 | $(CGREP) stack-buffer-overflow
-endif
diff --git a/src/test/run-make-fulldeps/sanitizer-cdylib-link/Makefile b/src/test/run-make-fulldeps/sanitizer-cdylib-link/Makefile
index 4b7fece36d92a..36cde355468be 100644
--- a/src/test/run-make-fulldeps/sanitizer-cdylib-link/Makefile
+++ b/src/test/run-make-fulldeps/sanitizer-cdylib-link/Makefile
@@ -1,3 +1,5 @@
+# needs-sanitizer-support
+
 -include ../tools.mk
 
 LOG := $(TMPDIR)/log.txt
@@ -8,15 +10,12 @@ LOG := $(TMPDIR)/log.txt
 # is correctly detected.
 
 ifeq ($(TARGET),x86_64-unknown-linux-gnu)
-ASAN_SUPPORT=$(SANITIZER_SUPPORT)
 
 # See comment in sanitizer-address/Makefile for why this is here
 EXTRA_RUSTFLAG=-C relocation-model=dynamic-no-pic
 endif
 
 all:
-ifeq ($(ASAN_SUPPORT),1)
 	$(RUSTC) -g -Z sanitizer=address --crate-type cdylib --target $(TARGET) $(EXTRA_RUSTFLAG) library.rs
 	$(RUSTC) -g -Z sanitizer=address --crate-type bin --target $(TARGET) $(EXTRA_RUSTFLAG) -llibrary program.rs
 	LD_LIBRARY_PATH=$(TMPDIR) $(TMPDIR)/program 2>&1 | $(CGREP) stack-buffer-overflow
-endif
diff --git a/src/test/run-make-fulldeps/sanitizer-dylib-link/Makefile b/src/test/run-make-fulldeps/sanitizer-dylib-link/Makefile
index 97f6172142224..b382ff5e7b24f 100644
--- a/src/test/run-make-fulldeps/sanitizer-dylib-link/Makefile
+++ b/src/test/run-make-fulldeps/sanitizer-dylib-link/Makefile
@@ -1,3 +1,5 @@
+# needs-sanitizer-support
+
 -include ../tools.mk
 
 LOG := $(TMPDIR)/log.txt
@@ -8,15 +10,11 @@ LOG := $(TMPDIR)/log.txt
 # is correctly detected.
 
 ifeq ($(TARGET),x86_64-unknown-linux-gnu)
-ASAN_SUPPORT=$(SANITIZER_SUPPORT)
-
 # See comment in sanitizer-address/Makefile for why this is here
 EXTRA_RUSTFLAG=-C relocation-model=dynamic-no-pic
 endif
 
 all:
-ifeq ($(ASAN_SUPPORT),1)
 	$(RUSTC) -g -Z sanitizer=address --crate-type dylib --target $(TARGET) $(EXTRA_RUSTFLAG) library.rs
 	$(RUSTC) -g -Z sanitizer=address --crate-type bin --target $(TARGET) $(EXTRA_RUSTFLAG) -llibrary program.rs
 	LD_LIBRARY_PATH=$(TMPDIR) $(TMPDIR)/program 2>&1 | $(CGREP) stack-buffer-overflow
-endif
diff --git a/src/test/run-make-fulldeps/sanitizer-invalid-cratetype/Makefile b/src/test/run-make-fulldeps/sanitizer-invalid-cratetype/Makefile
index dc37c0d0bc946..9581ac565ea02 100644
--- a/src/test/run-make-fulldeps/sanitizer-invalid-cratetype/Makefile
+++ b/src/test/run-make-fulldeps/sanitizer-invalid-cratetype/Makefile
@@ -1,18 +1,16 @@
+# needs-sanitizer-support
+
 -include ../tools.mk
 
 # NOTE the address sanitizer only supports x86_64 linux and macOS
 
 ifeq ($(TARGET),x86_64-apple-darwin)
-ASAN_SUPPORT=$(SANITIZER_SUPPORT)
 EXTRA_RUSTFLAG=-C rpath
 else
 ifeq ($(TARGET),x86_64-unknown-linux-gnu)
-ASAN_SUPPORT=$(SANITIZER_SUPPORT)
 EXTRA_RUSTFLAG=
 endif
 endif
 
 all:
-ifeq ($(ASAN_SUPPORT),1)
 	$(RUSTC) -Z sanitizer=address --crate-type proc-macro --target $(TARGET) hello.rs 2>&1 | $(CGREP) '-Z sanitizer'
-endif
diff --git a/src/test/run-make-fulldeps/sanitizer-leak/Makefile b/src/test/run-make-fulldeps/sanitizer-leak/Makefile
index 0f3c18f9293f5..101e8272ab91e 100644
--- a/src/test/run-make-fulldeps/sanitizer-leak/Makefile
+++ b/src/test/run-make-fulldeps/sanitizer-leak/Makefile
@@ -1,12 +1,11 @@
 -include ../tools.mk
 
+# needs-sanitizer-support
 # only-linux
 # only-x86_64
 # ignore-test
 # FIXME(#46126) ThinLTO for libstd broke this test
 
 all:
-ifdef SANITIZER_SUPPORT
 	$(RUSTC) -C opt-level=1 -g -Z sanitizer=leak -Z print-link-args leak.rs | $(CGREP) librustc_lsan
 	$(TMPDIR)/leak 2>&1 | $(CGREP) 'detected memory leaks'
-endif
diff --git a/src/test/run-make-fulldeps/sanitizer-memory/Makefile b/src/test/run-make-fulldeps/sanitizer-memory/Makefile
index 718d9637ea06d..b3376f8a72358 100644
--- a/src/test/run-make-fulldeps/sanitizer-memory/Makefile
+++ b/src/test/run-make-fulldeps/sanitizer-memory/Makefile
@@ -1,10 +1,9 @@
 -include ../tools.mk
 
+# needs-sanitizer-support
 # only-linux
 # only-x86_64
 
 all:
-ifdef SANITIZER_SUPPORT
 	$(RUSTC) -g -Z sanitizer=memory -Z print-link-args uninit.rs | $(CGREP) librustc_msan
 	$(TMPDIR)/uninit 2>&1 | $(CGREP) use-of-uninitialized-value
-endif
diff --git a/src/test/run-make-fulldeps/sanitizer-staticlib-link/Makefile b/src/test/run-make-fulldeps/sanitizer-staticlib-link/Makefile
index 2b444d667bfa3..8fa08688fdd71 100644
--- a/src/test/run-make-fulldeps/sanitizer-staticlib-link/Makefile
+++ b/src/test/run-make-fulldeps/sanitizer-staticlib-link/Makefile
@@ -1,18 +1,17 @@
+# needs-sanitizer-support
+
 -include ../tools.mk
 
 # This test builds a staticlib, then an executable that links to it.
-# The staticlib and executable both  are compiled with address sanitizer, 
+# The staticlib and executable both  are compiled with address sanitizer,
 # and we assert that a fault in the staticlib is correctly detected.
 
 ifeq ($(TARGET),x86_64-unknown-linux-gnu)
-ASAN_SUPPORT=$(SANITIZER_SUPPORT)
 EXTRA_RUSTFLAG=
 endif
 
 all:
-ifeq ($(ASAN_SUPPORT),1)
 	$(RUSTC) -g -Z sanitizer=address --crate-type staticlib --target $(TARGET) library.rs
 	$(CC) program.c $(call STATICLIB,library) $(call OUT_EXE,program) $(EXTRACFLAGS) $(EXTRACXXFLAGS)
 	LD_LIBRARY_PATH=$(TMPDIR) $(TMPDIR)/program 2>&1 | $(CGREP) stack-buffer-overflow
-endif
 
diff --git a/src/tools/compiletest/src/header.rs b/src/tools/compiletest/src/header.rs
index 64882c603bad3..fb6ada89171ab 100644
--- a/src/tools/compiletest/src/header.rs
+++ b/src/tools/compiletest/src/header.rs
@@ -88,6 +88,9 @@ impl EarlyProps {
             }
         }
 
+        let rustc_has_profiler_support = env::var_os("RUSTC_PROFILER_SUPPORT").is_some();
+        let rustc_has_sanitizer_support = env::var_os("RUSTC_SANITIZER_SUPPORT").is_some();
+
         iter_header(testfile, None, &mut |ln| {
             // we should check if any only-<platform> exists and if it exists
             // and does not matches the current platform, skip the test
@@ -116,6 +119,16 @@ impl EarlyProps {
                    config.parse_needs_matching_clang(ln) {
                     props.ignore = Ignore::Ignore;
                 }
+
+                if !rustc_has_profiler_support &&
+                   config.parse_needs_profiler_support(ln) {
+                    props.ignore = Ignore::Ignore;
+                }
+
+                if !rustc_has_sanitizer_support &&
+                   config.parse_needs_sanitizer_support(ln) {
+                    props.ignore = Ignore::Ignore;
+                }
             }
 
             if (config.mode == common::DebugInfoGdb || config.mode == common::DebugInfoBoth) &&
@@ -748,6 +761,14 @@ impl Config {
         self.parse_name_directive(line, "needs-matching-clang")
     }
 
+    fn parse_needs_profiler_support(&self, line: &str) -> bool {
+        self.parse_name_directive(line, "needs-profiler-support")
+    }
+
+    fn parse_needs_sanitizer_support(&self, line: &str) -> bool {
+        self.parse_name_directive(line, "needs-sanitizer-support")
+    }
+
     /// Parses a name-value directive which contains config-specific information, e.g., `ignore-x86`
     /// or `normalize-stderr-32bit`.
     fn parse_cfg_name_directive(&self, line: &str, prefix: &str) -> ParsedNameDirective {