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helicase500ali.fa
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>WP_004082808.1 reverse gyrase [Thermotoga maritima]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LPE-D-----------------------------SPSD----IYRALLERKTL-------K----EYR-FYH--EFWNEYEDFRSFFKKKF-GKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWL-AR-K--------G-K----KSALVFPTVTLVKQT---LERLQ-KL----ADEK--------------VK-------------IFGFY-SSM--KKEEKE-KFEKSFEE-DDY-H------ILVFSTQFVSKNREK-L-SQ--K-----RFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--EIIRKA-------FSTIKQGK--------------------------------------IYERP------------------KNLKP----------------G-IL--VVSSAT--AKPRGI-RPLLFRDLLNFTVGRLVS-VARNITHVRI----SSRS--------------------KEKLV------------ELLEIFR-D---GILIFAQTEEEGKE-------LYEY---LKRF-KFNVGETWSE---F---EKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSL-------EL-DK--------------------APRFV----------------LA-RVLK-----------------E--------MGL-IKA-----Q------------ENP-DVEELRKIAKEHLTQKEFVEKVKEMFRGV---VVK-DE-------D----LEL-IIPDVYTYIQASGRSSRILNGVLVKGVSVIFE--ED--EEIFESLKTRLL--LIAEE--EI------I-----------------EE------------AE------A-------NWKELVHEVEESRRRSE------R
>WP_008193954.1 MULTISPECIES: reverse gyrase [Thermotoga]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LPE-D-----------------------------SPSD----IYRALLERKTL-------K----EYR-FYH--EFWNEYEDFRSFFKKKF-GKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWL-AR-K--------G-K----KSALVFPTVTLVKQT---LERLQ-KL----ADEK--------------VK-------------IFGFY-SSM--KKEEKE-KFEKSFEE-DDY-H------ILVFSTQFVSKNREK-L-SQ--K-----RFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--EIIRKA-------FSTIKQGK--------------------------------------IYERP------------------KNLKP----------------G-IL--VVSSAT--AKPRGI-RPLLFRDLLNFTVGRLVS-VARNITHVRI----SSRS--------------------KEKLV------------ELLEIFR-D---GILIFAQTEEEGKE-------LYEY---LKRF-KFNVGETWSE---F---EKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSL-------EL-DK--------------------APRFV----------------LA-RVLK-----------------E--------MGL-IKA-----Q------------ENP-DVEELRKIAKEHLTQKEFVEKVKEMFRGV---VVK-DE-------D----LEL-IIPDVYTYIQASGRSSRILNGVLVKGVSVIFE--ED--EEIFESLKTRLL--LIAEE--EI------I-----------------EE------------AE------A-------NWKELVHEVEESRRRSE------R
>WP_038033294.1 MULTISPECIES: reverse gyrase [Thermotoga]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LLE-E-----------------------------SPSD----IYRALLERKTL-------K----EYR-FYH--DFWNEYEDFRSFFKKKF-RKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWL-AR-K--------G-K----KSALVFPTVALVKQT---LERLQ-KF----SDGK--------------VK-------------ILGFY-SSM--KKEEKE-KFEKSFEE-DDY-H------ILVFSTQFVSKNREK-L-SQ--K-----RFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--EIIRKA-------FSTIKQGK--------------------------------------IYERP------------------KSLKP----------------G-IL--VVSSAT--AKPRGI-RPLLFRDLLNFTVGRLVS-VARNITHVRI----SSRS--------------------KEKLI------------ELLEIFR-D---GILIFAQTEEEGKE-------LYEY---LKRF-KFNVGETWSE---F---EKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSL-------EF-DR--------------------APRFV----------------LA-RVLK-----------------E--------MGL-IKA-----Q------------ENP-DVEELRKIAKEHLSQKEFVEKIKEIFRGV---VVK-DE-------D----LEL-IIPDVYTYIQASGRSSRILNGVLVKGVSVIFE--ED--EEIFESLKTRLL--LIAEE--EI------I-----------------EE------------AE------A-------NWKELVHEVEESRKRIE------G
>WP_012310746.1 reverse gyrase [Thermotoga sp. RQ2]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LLE-E-----------------------------SPSD----IYRALLERKTL-------K----EYR-FYH--DFWNEYEDFRSFFKKKF-GKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWL-AR-K--------G-K----KSALVFPTVTLVKQT---LERLQ-EF----ADEK--------------VK-------------ILGFY-SSM--KKEEKE-KFEKSFEE-DDY-H------ILVFSTQFVSKNREK-L-SQ--K-----RFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--EIIRKA-------FSTIKQGK--------------------------------------IYERP------------------KSLKP----------------G-IL--VVSSAT--AKPRGI-RPLLFRDLLNFTVGRLVS-VARNITHVRI----STRS--------------------KEKLI------------ELLEIFR-D---GILIFTQTEEEGKE-------LYEY---LKRF-KFNVGETWSE---F---EKNFEDFKVGKLNILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSL-------EF-DR--------------------APRFV----------------LA-RVLK-----------------E--------MGL-IKA-----Q------------ENP-DVEELRKIAKEHLTQKEFVEKIKEIFRGV---VVK-DE-------D----LEM-TIPDVYTYIQASGRSSRILNGVLVKGVSVIFE--ED--EEIFESLKTRLL--LIAEE--EI------I-----------------EE------------SE------T-------NWKELVHEVEESRKRIE------G
>AJF34550.1 reverse gyrase [Thermotoga sp. TBXY761]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LLE-E-----------------------------SPSD----IYRALLERKTL-------K----EYR-FYH--DFWNEYEDFRSFFKKKF-RKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWL-AR-K--------G-K----KSALVFPTVALVKQT---LERLQ-KF----SDGK--------------VK-------------ILGFY-SSM--KKEEKE-KFEKSFEE-DDY-H------ILVFSTQFVSKNREK-L-SQ--K-----RFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--EIIRKA-------FSTIKQGK--------------------------------------IYERP------------------KSLKP----------------G-IL--VVSSAT--AKPRGI-RPLLFRDLLNFTVGRLVS-VARNITHVRI----SSRS--------------------KEKLI------------ELLEIFR-D---GILIFAQTEEEGKE-------LYEY---LKRF-KFNVGETWSE---F---EKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSL-------EF-DR--------------------APRFV----------------LA-RVLK-----------------E--------MGL-IKA-----Q------------ENP-DVEELRKIAKEHLSQKEFVEKIKEIFRGV---VVK-DE-------D----LEL-IIPDVYTYIQASGRSSRILNGVLVKGVSVIFE--ED--EEIFESLKTRLL--LIAEE--EI------I-----------------EE------------AE------A-------NWKELVHEVEESRKRIE------G
>AJA38645.1 reverse gyrase [Thermotoga sp. TBYP3.1.4.1]
----------------------------------------------------------------------------M-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LLE-E-----------------------------SPSD----IYRALLERKTL-------K----EYR-FYH--DFWNEYEDFRSFFKKKF-RKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWL-AR-K--------G-K----KSALVFPTVALVKQT---LERLQ-KF----SDGK--------------VK-------------ILGFY-SSM--KKEEKE-KFEKSFEE-DDY-H------ILVFSTQFVSKNREK-L-SQ--K-----RFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--EIIRKA-------FSTIKQGK--------------------------------------IYERP------------------KSLKP----------------G-IL--VVSSAT--AKPRGI-RPLLFRDLLNFTVGRLVS-VARNITHVRI----SSRS--------------------KEKLI------------ELLEIFR-D---GILIFAQTEEEGKE-------LYEY---LKRF-KFNVGETWSE---F---EKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSL-------EF-DR--------------------APRFV----------------LA-RVLK-----------------E--------MGL-IKA-----Q------------ENP-DVEELRKIAKEHLSQKEFVEKIKEIFRGV---VVK-DE-------D----LEL-IIPDVYTYIQASGRSSRILNGVLVKGVSVIFE--ED--EEIFESLKTRLL--LIAEE--EI------I-----------------EE------------AE------A-------NWKELVHEVEESRKRIE------G
>WP_011943348.1 reverse gyrase [Thermotoga petrophila]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LPE-E-----------------------------SPSD----IYGALLERKTL-------K----EYR-FYH--EFWNEYEDFRSFFKKKF-GKDLTGYQRLWAKRIIQGKSFTMVAPTGVGKTTFGMMTALWL-AE-K--------G-R----KSALIFPTVALVKQT---LERLQ-KF----SDGK--------------VK-------------ILGFY-SSM--KKEEKE-KFEKSFEE-DDY-H------ILVFSTQFVSKNREK-L-SQ--K-----RFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--EIIKKA-------FSAIKQGR--------------------------------------IYERP------------------KNLKP----------------G-IL--VVSSAT--AKPRGI-RPLLFRDLLNFTVGRLVS-VARNITHVRI----STRS--------------------KEKLI------------ELLEIFR-D---GILIFTQTEEEGKE-------LYEY---LKRF-KFNVGETWSE---F---EKNFEDFKVGKLNILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSL-------EF-DR--------------------APRFV----------------LA-RVLK-----------------E--------MGL-IKA-----Q------------ENP-DVEELRKIAKEHLTQKEFVEKVKEMFRGV---VVK-DE-------D----LEM-TIPDVYTYIQASGRSSRILNGVLVKGVSVIFE--ED--EEIFESLKTRLL--LIAEE--EI------I-----------------EE------------SE------T-------NWKELVHEVEESRKRIE------G
>AIY88087.1 reverse gyrase [Thermotoga sp. Cell2]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LLE-E-----------------------------SPSD----IYRALLERKTL-------K----EYR-FYH--DFWNEYEDFRSFFKKKF-RKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWL-AR-K--------G-K----KSALVFPTVALVKQT---LERLQ-KF----SDGK--------------VK-------------ILGFY-SSM--KKEEKE-KFEKSFEE-DDY-H------ILVFSTQFVSKNREK-L-SQ--K-----RFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--EIIRKA-------FSTIKQGK--------------------------------------IYERP------------------KSLKP----------------G-IL--VVSSAT--AKPRGI-RPLLFRDLLNFTVGRLVS-VARNITHVRI----SSRS--------------------KEKLI------------ELLEIFR-D---GILIFAQTEEEGKE-------LYEY---LKRF-KFNVGETWSE---F---EKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSL-------EF-DR--------------------APRFV----------------LA-RVLK-----------------E--------MGL-IKA-----Q------------ENP-DVEELRKIAKEHLSQKEFVEKIKEIFRGV---VVK-DE-------D----LEL-IIPDVYTYIQASGRSSRILNGVLVKGVSVIFE--ED--EEIFESLKTRLL--LIAEE--EI------I-----------------EE------------AE------A-------NWKELVHEVEESRKRIE------G
>WP_012896154.1 reverse gyrase [Thermotoga naphthophila]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LLE-E-----------------------------SPSD----IYRALLERKTL-------K----EYR-FYH--DFWNEYEDFRSFFKKKF-GKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWL-AG-K--------G-K----KSALIFPTVTLVKQT---LERLQ-EF----ADEK--------------VK-------------ILGFY-SSM--KKEEKE-KFEKSFEE-DDY-H------ILVFSTQFVSKNREK-L-SQ--K-----RFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--EIIKKA-------FSAIKQGR--------------------------------------IYERP------------------KNLKP----------------G-IL--VVSSAT--AKPRGI-RPLLFRDLLNFTVERLVS-VARNITHVRI----STRS--------------------KEKLI------------ELLEIFR-D---GILIFTQTEEEGKE-------LYEY---LRRF-KFNVGETWSE---F---EKNFEDFKSGKLNVLIGVQAYYGKLTRGVDLPERIKYAIFWGTPSMRFSL-------EL-DR--------------------VPRFV----------------LA-RVLK-----------------E--------MGL-IKV-----Q------------ENP-DVEGLRKMAKERLSQEEFVEKVKEIFRGA---VVK-DE-------D----LEL-IIPDVYTYIQASGRSSRILNGVLVKGVSVIFE--ED--EEIFESLKTRLL--LIAEE--EI------I-----------------EE------------SE------A-------NWKELIHEVEESRKRIE------G
>HBU00097.1 reverse gyrase [Thermotoga naphthophila]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVFSTQFVSKNREK-L-SQ--K-----RFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--EIIRKA-------FSTIKQGK--------------------------------------IYERP------------------KSLKP----------------G-IL--VVSSAT--AKPRGI-RPLLFRDLLNFTVGRLVS-VARNITHVRI----STRS--------------------KEKLI------------ELLEIFR-D---GILIFTQTEEEGKE-------LYEY---LKRF-KFNVGETWSE---F---EKNFEDFKVGKLNILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSL-------EF-DR--------------------APRFV----------------LA-RVLK-----------------E--------MGL-IKA-----Q------------ENP-DVEELRKIAKEHLTQKEFVEKVKEMFRGV---VVK-DE-------D----LEM-TIPDVYTYIQASGRSSRILNGVLVKGVSVIFE--ED--EEIFESLKTRLL--LIAEE--EI------I-----------------EE------------SE------T-------NWKELVHEVEESRRRIE------G
>KHC93356.1 reverse gyrase [Thermotoga sp. Mc24]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LPE-E-----------------------------SPSD----IYGALLERKTL-------K----EYR-FYH--EFWNEYEDFRSFFKKKF-GKDLTGYQRLWAKRIIQGKSFTMVAPTGVGKTTFGMMTALWL-AE-K--------G-R----KSALIFPTVALVKQT---LERLQ-KF----SDGK--------------VK-------------ILGFY-SSM--KKEEKE-KFEKSFEE-DDY-H------ILVFSTQFVSKNREK-L-SQ--K-----RFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--EIIKKA-------FSAIKQGR--------------------------------------IYERP------------------KNLKP----------------G-IL--VVSSAT--AKPRGI-RPLLFRDLLNFTVGRLVS-VARNITHVRI----SSRS--------------------KEKLV------------ELLEVFR-D---GILIFAQTEEEGKE-------LYEY---LRRF-KFNVGETWSE---F---EKNFEDFKSGKLNVLIGVQAYYGKLTRGVDLPERIKYAIFWGTPSMRFSL-------EL-DR--------------------VPRFV----------------LA-RVLK-----------------E--------MGL-IKV-----Q------------ENP-DVEGLRKMAKERLSQEEFVEKVKEIFRGA---VVK-DE-------D----LEL-IIPDVYTYIQASGRSSRILNGVLVKGVSVIFE--ED--EEIFESLKTRLL--LIAEE--EI------I-----------------EE------------SE------A-------NWKELVHEVEESRKRIE------G
>WP_101512579.1 reverse gyrase [Thermotoga sp. SG1]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGVNTD-ERNERGLPCEVC-LPE-E-----------------------------SPFD----IYEALLERRTL-------K----DYR-FYH--RFWNEYEDFRNFFKKMF-GKNLTGYQRLWAKRTILGKSFTMVAPTGVGKTTFGMVASLWL-AK-K--------G-K----RSALIFPTVTLVKQT---LERLR-SM----SED---------------VK-------------IVGFY-SSM--GKEERK-RFEESFEK-DDY-H------VLVVSTQFVSRHREE-L-SR--K-----KFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--DVIKKA-------LFAIKQGK--------------------------------------IYERP------------------DNLKT----------------G-IL--VVSSAT--ARPRGI-RPLLFRDLLNFTVGRLVS-VSRNITHVRI----PRKS--------------------KERLM------------ELLRMFK-D---GVLIFTQTEEEGKN-------LVDY---LKGQ-GIKVEGTWER---F---EENFDAFKNGEINVLVGVQAYYGKLTRGVDLPEKIKYVVFWGVPSMRFSL-------EP-DK--------------------APQFV----------------LT-RLLR-----------------E--------SGL-IKG-----R------------EAN-E-EKLRELAKSHFSQEEFVERVKEIFRGS---AVR-GK-------------EL-IIPDIYTYIQASGRSSRILNGVLVKGLAVIFE--ED--EEIFESLKTRLL--LVAEE--EI------L-----------------EE------------SE------A-------DWEKLVREVEESRKSLK------K
>WP_041844072.1 reverse gyrase [Thermotoga sp. RQ7]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------LKYHHSCINCRGVNTD-ERNERGLPCEVC-LPE-E-----------------------------SPSD----IYEALLERRTL-------K----DYR-FYH--RFWSEYEDFRNFFKEMF-GKNLTGYQRLWAKRTILGKSFTMVAPTGVGKTTFGMVASLWL-AR-K--------G-K----KSALIFPTVTLVKQT---LERLR-NM----SED---------------AK-------------IIGFY-SSM--GKEEKK-KFEESFEK-DDY-H------ILVVSTQFVSRHREE-L-SR--K-----KFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--NVIKKA-------LSAIKQGK--------------------------------------IYERP------------------DNLKT----------------G-IL--VVSSAT--ARPRGI-RPLLFRDLLNFTVGRLVS-VSRNITHVRI----SRKS--------------------RERLV------------ELLRVFR-D---GVLIFTQTEEEGRN-------LVDY---LKGQ-GIRVEGTWER---F---EENFDAFKNGDIDVLVGVQAYYGKLTRGVDLPERIKYVIFWGVPSMKFPL-------EL-DR--------------------APKFV----------------LT-RLLR-----------------E--------SGL-IKG-----R------------EVN-E-EELRKLAKSHFSQEEFVERVKEIFRGS---AVR-GE-------------EL-IIPDIYTYIQASGRSSRILNGVLVKGLAVIFE--ED--EEIFESLRTRLL--LVAEE--EI------L-----------------EE------------SE------V-------DWEKLIREVEESRKSLK------K
>WP_015919009.1 reverse gyrase [Thermotoga neapolitana]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------LKYHHSCINCRGVNTD-ERNERGLPCEVC-LPE-E-----------------------------SPSD----IYEALLERRTL-------K----DYR-FYH--RFWREYEDFRNFFKEMF-GKNLTGYQRLWAKRTILGKSFTMVAPTGVGKTTFGMVASLWL-AR-K--------G-K----KSALIFPTVTLVKQT---LERLR-NM----SED---------------AK-------------IIGFY-SSM--GKEEKK-KFEESFEK-DDY-H------ILVVSTQFVSRHREE-L-SR--K-----KFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--NVIKKA-------LSAIKQGK--------------------------------------IYERP------------------DNLKT----------------G-IL--VVSSAT--ARPRGI-RPLLFRDLLNFTVGRLVS-VSRNITHVRI----SRKS--------------------RERLV------------ELLRVFR-D---GVLIFTQTEEEGRN-------LVDY---LKGQ-GIRVEGTWER---F---EENFDAFKNGDIDVLVGVQAYYGKLTRGVDLPERIKYVIFWGVPSMKFPL-------EL-DR--------------------APKFV----------------LT-RLLR-----------------E--------SGL-IKG-----R------------EVN-E-EELRKLAKSHFSQEEFVERVKEIFRGS---AVR-GE-------------EL-IIPDIYTYIQASGRSSRILNGVLVKGLAVIFE--ED--EEIFESLRTRLL--LVAEE--EI------L-----------------EE------------SE------V-------DWEKLIREVEESRKSLK------K
>CAI44249.1 reverse gyrase [Thermotoga neapolitana LA10]
-------------------------------------MHERENR-----------------QP-DRKTKEVSGELAV-------------------------------------N-------------------------------------------------LKYHHSCINCRGVNTD-ERNERGLPCEVC-LPE-E-----------------------------SPSD----IYEALLERRTL-------K----DYR-FYH--RFWREYEDFRNFFKEMF-GKNLTGYQRLWAKRTILGKSFTMVAPTGVGKTTFGMVASLWL-AR-K--------G-K----KSALIFPTVTLVKQT---LERLR-NM----SED---------------AK-------------IIGFY-SSM--GKEEKK-KFEESFEK-DDY-H------ILVVSTQFVSRHREE-L-SR--K-----KFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--NVIKKA-------LSAIKQGK--------------------------------------IYERP------------------DNLKT----------------G-IL--VVSSAT--ARPRGI-RPLLFRDLLNFTVGRLVS-VSRNITHVRI----SRKS--------------------RERLV------------ELLRVFR-D---GVLIFTQTEEEGRN-------LVDY---LKGQ-GIRVEGTWER---F---EENFDAFKNGDIDVLVGVQAYYGKLTRGVDLPERIKYVIFWGVPSMKFPL-------EL-DR--------------------APKFV----------------LT-RLLR-----------------E--------SGL-IKG-----R------------EVN-E-EELRKLAKSHFSQEEFVERVKEIFRGS---AVR-GE-------------EL-IIPDIYTYIQASGRSSRILNGVLVKGLAVIFE--ED--EEIFESLRTRLL--LVAEE--EI------L-----------------EE------------SE------V-------DWEKLIREVEESRKSLK------K
>WP_101511143.1 reverse gyrase [Thermotoga sp. KOL6]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCNGVNTD-ERNERGLPCEIC-LPG-E-----------------------------SPSD----IYNELLTRGTL-------K----DYR-FYH--DFWNRYEEFRNFFKKSF-GKDLTGYQRLWAKRIVLGKSFTMVAPTGVGKTTFGMIAALWL-SR-K--------R-K----KSVLIFPTVTLVKQA---LERLR-EM----ADEK--------------TK-------------ILGFY-SSM--KKEEKE-KFEKGFES-GDY-H------ILVVSTQFVSKNRER-L-AK--R-----KFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--EEIKKA-------LFFINRGQ--------------------------------------TYERP------------------KNLRT----------------G-IL--VVSSAT--ARPRGI-RPLLFRDLLNFTVGRLVS-VARNITHVRI----STKS--------------------KKRLL------------ELVKNLK-D---GILIFSKTEEEGEG-------LVEY---LRSN-GIKVGETWSR---F---EENFEDFKEGKINVLVGLQAYYGKLTRGVDLPERIKYVIFWGIPSMRFSL-------KL-DK--------------------VPKFI----------------LV-RVLR-----------------E--------AGL-IKA-----QGR--------ILEDA----KLQQIAQEHFSQEEFVKKVKEIFKGA---TIE-DE-------------EL-IIPDVYTYIQASGRSSRILNGVLVKGIAVIFE--EN--EEIFESLKTRLL--LVAEE--EV------V-----------------EE------------DE------I-------DWKELIREVEESRKKVT------K
>PMQ01653.1 reverse gyrase [Dictyoglomus sp. NZ13-RE01]
--------------------------------------------------------------------------MAI-------------------------------------G-------------------------------------------------AKYYHSCVNCGDINTD-HRNEKGLPCEKC-LPT-EG-----------------------------TDN----LLHDLEKFNTL-------K----DYL-FYS--NFYSQYEEFLKFFEKKF-GKPLTGYQRFWAKRLLLSKSFTMVAPTGIGKTTFGLISALWF-AR-N--------N-K----KVALIFPTVSLVKQA---EERLR-KY----SEGE------P-KD--N-IK-------------ILSYH-SSM--NSKDKE-KFEKDFLE-DNF-D------ILIISSQFISRRRDI-F-SS--K-----KFDLVFVDDVDAVLKS-SKNIDTLLEMIGIPK--ELINEA-------LTNIKLR------------------------------------------KF------------------GTLN---NNRIE--NH-----G-IL--IVSSAT--AKPRGI-RPLLFRELLGFEIGRFVL-SIRNIVNVRV----NKKS--------------------KERLL------------EIIRLLK-D---GVLLFVENEEEGEK-------LVDY---LLEN-GIRVGKSWDN---F---MDSFERFKSGELDVLCGIYTYYGKLVRGIDLPTRIKYAVFWGTPCFRFST-------DI-DK--------------------APRFV----------------IE-RVLR-----------------E--------KLE-DNQ-----KMS-RF---ISNLSNI-PIESLRESVRKFISSEEWDKYLKELFPNI---KF--EN-------K-----EM-VVPDVYTYIQASGRTSRMLEGRLTRGISILFE--DD--DIVFESLRSRLM--FLTEE--DW------V-----------------SE------------EE------I-------DWSKLIEEVEESRVLRG------E
>WP_011917108.1 reverse gyrase [Caldicellulosiruptor saccharolyticus]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINSD-TRNQKGLPCEKC-LPF-EN-----------------------------NMN----ILESLKEHNSL-------K----DYA-YFW--NFQNEYKEFEKFFVSKV-GKPMTGYQRLWARRLLLSKSFTLIAPTGLGKTTFGLVATLWM-AK-N--------G-K----KVALIFPTVSLVEQT---HQRLL-EF----ANKE------P-KE--N-VK-------------ILSYK-SSM--KRTEKD-EFEKNFEN-GEF-D------ILIVSSQFISKRKDD-L-AK--K-----VFSLVFVDDVDAILKS-SKNIDTLLQMIGIDQ--KTIDKT-------FENLKKG-----------------------------------------VKY------------------PEQKQNGTSSTP--SK-----G-IL--IVSSAT--AKPQGL-KPLLFRELLGFEIGRFTF-SVRNITNIRI----AGKS--------------------KVKLL------------ETIKILN-D---GILLFVENEEEGKD-------VTNF---LENE-GISVGKTWED---F---EKSFEEFKDGKLKILCGIYSYYGKLVRGIDLPLRIKYSIFWGTPSFRFST-------DI-EK--------------------APRFV----------------LE-RVFS-----------------D--------YLE-EHP-----KLK-SF---FKNIDKY-QVERLREVVKKYIPQDRWTDFIKKSFSNL---KIS-DE-------G-----QI-FFPDVFTYIQGSGRTSRMLGSSLTKGVSILFE--DD--DLLFESLRSRLM--FLLDE--EW------K-----------------TE------------DE------V-------CFEDLIKEVEMSRNEALI-----D
>WP_039764098.1 reverse gyrase [Caldicellulosiruptor sp. F32]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINSD-TRNQKGLPCEKC-LPF-EN-----------------------------NMN----ILESLKEHNSL-------K----DYA-YFW--NFKNEYKEFEKFFVSKV-GKPMTGYQRLWARRLLLSKSFTLIAPTGLGKTTFGLVATLWM-AK-N--------G-K----KVALIFPTVSLVEQA---HQRLL-EF----ANKE------P-KE--S-VK-------------ILSYK-SSM--KRTEKD-EFEKNFEN-GEF-D------ILIVSSQFISKRKDD-L-AK--K-----VFSLVFVDDVDAILKS-SKNIDTLLQMIGIDQ--KTIDQT-------FENLKKG-----------------------------------------IKY------------------PEQKQNGTSSTL--SK-----G-IL--IVSSAT--AKPQGL-KPLLFRELLGFEIGRFTF-SIRNITNIRI----AKKS--------------------KEKLL------------ETIKILN-D---GILLFVENEEEGKD-------VINF---LENE-GISVGKTWED---F---EKSFEEFKDGKLKILCGIYSYYGKLVRGIDLPLRIKYSIFWGTPSFRFST-------DI-EK--------------------APRFV----------------LE-RVFS-----------------D--------YLE-EHP-----KLK-SF---FKGIDRY-RVERLREIVKKYIPQDKWTVFVKKSFSNL---KIS-DE-------G-----QI-FFPDVFTYIQGSGRTSRMLGSSLTKGVSILFE--DD--DLLFESLRSRLM--FLLDE--EW------K-----------------TE------------DE------V-------CFEDLIKEVEMSRNEASI-----T
>WP_045165808.1 reverse gyrase [Caldicellulosiruptor naganoensis]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINSD-TRNQKGLPCEKC-LPF-EN-----------------------------SMN----ILESLKQHNSL-------K----DYA-YFW--NFQNEYKEFEKFFVSKV-GKPMTGYQRLWARRLLLSKSFTLIAPTGLGKTTFGLVATLWM-TK-N--------G-K----KVALIFPTVSLVEQA---HQRLL-EF----ANKE------P-KE--N-VK-------------ILSYK-SSM--KKTEKD-EFEKSFEN-GEF-D------ILIVSSQFISKRKDD-L-AK--K-----VFSLVFVDDVDAILKS-SKNIDTLLQMIGIDQ--NTIDQT-------FENLKKG-----------------------------------------IKY------------------PEQKQNGTSSTL--SK-----G-IL--IVSSAT--AKPQGL-KPLLFRELLGFEIGRFTF-SIRNITNIRI----AEKS--------------------KEKLL------------ETIKILN-D---GILLFVENEEEGKD-------VTHF---LENE-GISVGKTWED---F---EKSFEEFKDGKLKILCGIYSYYGKLVRGIDLPLRIKYSIFWGTPSFRFST-------DI-EK--------------------APRFV----------------LE-RVFS-----------------D--------YLE-EHP-----KLK-SF---FKGIDRY-QVERLREVVKKYISQDKWTVFVKKSFSNL---KIS-DE-------G-----QI-FFPDVFTYIQGSGRTSRMLGSSLTKGVSILFE--DD--DLLFESLRSRLM--FLLDE--EW------K-----------------TE------------NE------V-------CFEDLIKEVEMSRNETLI-----N
>WP_127352095.1 reverse gyrase [Caldicellulosiruptor changbaiensis]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINSD-TRNQKGLPCEKC-LPF-EN-----------------------------GMN----ILESLKQYNSL-------K----DYA-YFW--NFQNEYKEFEDFFVSKV-GKPMTGYQRLWARRLLLSKSFTLIAPTGLGKTTFGLVATLWM-AK-A--------G-K----KVALIFPTVSLVEQA---HQRLL-EF----ANKE------P-KE--N-VK-------------ILSYK-SSM--KKTEKD-EFEKSFEN-GEF-D------ILIVSSQFISKRKDD-L-AK--K-----VFSLVFVDDVDAILKS-SKNIDTLLQMIGIDQ--KTIDKT-------FENLKKG-----------------------------------------TKY------------------SDQKLNGTPSTS--SK-----G-IL--IVSSAT--AKPQGL-KPLLFRELLGFEIGRFTF-SIRNITNIRI----AEKS--------------------KEKLL------------ETIRILN-D---GILLFVENEEEGKD-------VTNF---LENK-GIPVGKTWED---F---EKSFEQFREGKLKILCGIYSYYGKLVRGIDLPLRIKYSIFWGTPSFRFST-------DI-EK--------------------APRFV----------------LE-RVFS-----------------D--------YLE-EHP-----KLK-SF---FKNIDRY-QVERLREVVKKYIPQDRWVAFVKKSFPNL---KIS-DE-------G-----QI-FFPDVFTYIQGSGRTSRMLGSSLTKGVSILFE--DD--NLLFESLRSRLM--FLLDE--EW------K-----------------TE------------NE------V-------CFEDLIKEVEMSRNETLI-----N
>WP_045174597.1 reverse gyrase [Caldicellulosiruptor danielii]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINSD-TRNQKGLPCEKC-LPS-EN-----------------------------GES----IFESLKQTHNL-------K----DYA-HLW--KFQNEYKEFEKFFISTV-GKPMTGYQRLWARRLLLSKSFTLIAPTGLGKTTFGLVATLWM-AK-N--------R-K----KVALIFPTVSLVEQA---QQRLL-EF----ASKE------T-KI--D-VK-------------ILAYK-SSM--KKSEKD-EFEKSFEN-DEF-D------ILIASSQFISKRKDD-L-AK--K-----VFSLVFVDDVDAVLKS-SKNIDTLLQMIGIDQ--KTIDQT-------LENLKNG-----------------------------------------TKS------------------SELKLNGTPSAS--PK-----G-IL--IVSSAT--AKPQGL-KPLLFRELLGFEIGRFTF-SIRNITNIRI----AGKS--------------------KEKLL------------ETIRILN-D---GILLFVENEEEGKD-------VTNF---LENK-GLSVGKTWED---F---EKSFEQFKEGKLKILCGIYSYYGKLVRGIDLPLRIRYSIFWGTPSFRFST-------DI-EK--------------------APRFV----------------LE-RVFS-----------------D--------YLE-EYP-----KLK-SF---FKNIDRY-QVERLREVVKKYIPQDRWATFVKKSFSNL---KIS-DE-------G-----QI-LFPDVFTYIQGSGRTSRMLGSSLTKGVSILFE--DD--DLLFESLKSRLM--FLLDE--EW------K-----------------TE------------DE------V-------CFEDLIKEVEMSRNEASI-----N
>RKX56552.1 reverse gyrase [Thermotoga sp.]
--------------------------------------------------------------------------MAV-------------------------------------G-------------------------------------------------LRYHHSCVNCFGLNTD-ERNEKGLPCEVC-LSE-EV----------------------------EPEE----VLQRLEKNGKL-------M----FYR-YIK--DFEKNFSDFSDFFKRVT-GFPPTGFQRIWMKRVLLSKSFTAIAPTGVGKTTFGMVTSLWF-SF-H--------A-K----RSAMILPTLTLVLQIRERLEGMV-KR----IDGD--------------VD-------------IIHYH-AGM--KEKEKK-EFFEKLER-GDF-H------IAIFSTQFLSKNWEI-L-SK--L-----KFDFVFVDDVDAVLKS-SKNIDTILMMLGIEK--EAIEKA-------LMKLRK------------------------------------------KRE------------------EELEIG--------EH-----G-IL--VVSSAT--ARPKGI-RPLLFRELLGFDVGTLVV-GVRNITNLRV----KSED--------------------TDDLL------------DLLEKLK-D---GIVLLARDEKTIKW-------LSEI---VEGA-GFPVGKSWEN---L---EKALEDFSEGKVSIIAGVYSYYGKLVRGLDLPKRVKFVIFWGTPVFEYFI-------DM-EK--------------------APRFV----------------IR-RVLF-----------------E--------VSK-KNT-----RVK-KL---LQIVDRS-DIETLRNRLKVVLTEDEWEETIKRIFARY---RIK-ER-------------KL-LLPDVLTYIQASGRSSRLLGSKLTKGVSILFE--TD--DAVFESLKERLD--WLTEE--EW------I-----------------DL------------ED------A-------DWETLLKEVEESRKEEK------K
>OQX58454.1 reverse gyrase [Thermotoga sp. 4484_232]
--------------------------------------------------------------------------MAV-------------------------------------G-------------------------------------------------LRYHHSCVNCFGLNTD-ERNEKGLPCEVC-LSE-EV----------------------------EPGE----VLQRLEKNGKL-------M----FYR-YIK--DFEKNFSDFSDFFKRVT-GFPPTGFQRIWMKRVLLSKSFTAIAPTGVGKTTFGMVTSLWF-SF-H--------A-K----RSAMILPTLTLVLQIRERLEGMV-KR----IDGD--------------VD-------------IIHYH-AGM--KEKEKK-EFFEKLER-GDF-H------IAIFSTQFLSKNREI-L-SK--L-----KFDFVFVDDVDAVLKS-SKNIDTILMMLGIEK--EAIEKA-------LMKLRK------------------------------------------KRE------------------EELEIG--------EH-----G-IL--VVSSAT--ARPKGI-RPLLFRELLGFDVGTLVV-GVRNITNLRV----KSED--------------------TDDLL------------DLLEKLK-D---GIVLLARDEKTIKW-------LSEI---VEGA-GFPVGKSWEN---L---EKALEDFSEGKVSIIAGVYSYYGKLVRGLDLPKRVKFVIFWGTPVFEYFI-------DM-EK--------------------APRFV----------------IR-RVLF-----------------E--------VSK-KNT-----RVK-KL---LQIVDRS-DIETLRNRLKVVLTEDEWEETIKRIFARY---RIK-ER-------------KL-LLPDVLTYIQASGRSSRLLGSKLTKGVSILFE--TD--EAVFESLRERLD--WLTEE--EW------I-----------------DL------------ED------A-------DWETLLKEVEESRKEEK------K
>WP_045169780.1 reverse gyrase [Caldicellulosiruptor morganii]
--------------------------------------------------------------------------MST-------------------------------------G-------------------------------------------------AKYYHSCINCGGINSD-TRNQKGLPCEKC-LPS-EE------------------------------EN----ILEYLTQTHNL-------K----DYA-NFL--AFQNEYREFEKFFVSTV-GKPMTGYQRLWARRLLLSKSFTLIAPTGLGKTTFGLVATLWL-AK-K--------R-K----KVALIFPTVSLVQQA---QQRLL-EF----ANRE--------RL--D-VK-------------ILAYK-SSM--KKIEKE-EFEKSFET-DQF-D------ILLVSSQFISKRKDD-I-AK--K-----VFSLVFVDDVDAVLKS-SKNIDTLLQMIGIDQ--NTIEKT-------LENLKKG-----------------------------------------NKA------------------FESNLNSVNSSL--SS-----G-TL--IVSSAT--ARPQGL-KPLLFRELLGFEIGRFTF-SVRNITNIRI----AEKS--------------------KEKLL------------KTIRVLS-D---GILLFVENEDEGKE-------ITNF---LENE-GINVGKTWED---F---EKSFELFKEGKLKILCGIYSYYGKLVRGIDLPLRIKYTIFWGTPSFRFSS-------DI-EK--------------------APRFV----------------LE-RVFL-----------------D--------YLD-EHP-----KLK-SY---FKNVEKL-QAERLRDIAKKYIPLDRWADFVRKSFAHL---KIS-EN-------G-----QI-CFPDVFTYIQGSGRTSRMLGSTLTKGVSILFE--ED--NLLFESLRSRLM--FLLDE--EW------K-----------------TE------------DE------V-------KLEDLIKEVEISRIEALT-----N
>WP_029228260.1 reverse gyrase [Caldicellulosiruptor acetigenus]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNEKGLPCEQC-LSQ-EQ----------------------------ISKN----IFESLKKKGTL-------K----DYQ-IYW--NFQQNFDTFEKFFEHIF-QKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFL-AL-N--------G-K----KSALVFPTISLAQQS---FERLE-EF----KTKL------E-NA--NAVK-------------ILLFN-SSM--TKSRKE-EFEKRFLS-CDF-D------ILIITTQFVSKRKDV-L-SK--M-----FFDLVFVDDVDAILKS-SKNIDTLLQMIGFSE--DEIEKA-------TERLRSK-----------------------------------------NKE------------------SGQDTV-SNGSK--NK-----G-ML--IVSSAT--AKPQGL-KPLLFRELLGFEIGRFTF-NIRNITNIRI----KNKS--------------------NKKLL------------EIINILK-D---GILLFVNTEEEGKE-------IVKF---LLEN-GIKIGATWND---F---EKEFELFKEGKLNVICGVSSYYGKLIRGIDLPLRIKYCIFWETPCFRFLI-------DM-DK--------------------APRFV----------------LE-RVFV-----------------E--------YLD-NHP-----KLK-EY---FKNVDSL-QTEKLRQLVSKYISKEDYSKIVNEIFSHL---KLT-DD-------G-----KL-VIPDVPTYIQGSGRTSRMFGMRLTKGVSILFE--ED--DTIFESLKSRLL--FLLDE--EW------M-----------------EE------------NE------V-------DFENLMEEVEESRKIQNH-----D
>WP_013432424.1 reverse gyrase [Caldicellulosiruptor kristjanssonii]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-IRNENGLPCEQC-LSQ-EQ----------------------------IN-D----IYESLKKMGTL-------K----DYR-LYW--NFQQNFDMFEKFFEHIF-QKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFL-AL-N--------G-K----KSALVFPTISLAQQS---FERLE-EF----KAKL------E-NA--NAVK-------------ILLFN-SSM--TKSRKE-EFEKRFLS-CDF-D------ILIITTQFVSKRKDV-L-SK--M-----FFDLVFVDDVDAILKS-SKNIDTLLQMIGFSE--DEIEKA-------TERLRSK-----------------------------------------NKE------------------NGQDTV-SNGSK--NK-----G-ML--IVSSAT--AKPQGL-KPLLFRELLGFEIGRFTF-NIRNITNIRI----KKKS--------------------KEKLL------------EIINILK-D---GILLFVNTEEEGKE-------IVKF---LLEN-GIKIGATWND---F---EKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFKFLI-------DM-DK--------------------APRFV----------------LE-RVFV-----------------E--------YLD-NHP-----KLK-GY---FKSVDSL-QTEKLRQLVSKYISKEDYSKIVNEIFSHL---KLT-DD-------G-----KL-VIPDVPTYIQGSGRTSRMFGMRLTKGVSILFE--ED--DTIFESLKSRLM--FLLDE--EW------V-----------------EE------------NG------V-------DFKNLMEEVEESRKIQNH-----D
>RKX49397.1 reverse gyrase, partial [Thermotogae bacterium]
--------------------------------------------------------------------------MAV-------------------------------------G-------------------------------------------------LRYHHSCVNCFGLNTD-ERNEKGLPCEVC-LSE-EV----------------------------EPEE----VLQRLEKNGKL-------M----FYR-YIK--DFEKNFSDFSDFFKRVT-GFPPTGFQRIWMKRVLLSKSFTAIAPTGVGKTTFGMVTSLWF-SL-H--------A-K----RSAMILPTLTLVLQIRERLEGMV-KR----IDGD--------------VD-------------IIHYH-AGM--KEKEKK-EFFEKLER-GDF-H------IAIFSTQFLSKNREI-L-SK--L-----KFDFVFVDDVDAVLKS-SKNIDTILMMLGIEK--EAIEKA-------LMKLRK------------------------------------------KRE------------------EELEIG--------EH-----G-IL--VVSSAT--ARPKGI-RPLLFRELLGFDVGTLVV-GVRNITNLRV----KSED--------------------TDDLL------------DLLEKLK-D---GIVLLARDEKTIKW-------LSEI---VEGA-GFPVGKSWEN---L---EKALEDFSEGKVSIIAGVYSYYGKLVRGLDLPKRVKFVIFWGTPVFEYFI-------DM-EK--------------------APRFV----------------IR-RVLF-----------------E--------VSK-KNT-----RVK-KL---LQIVDRS-DIETLRNRLKVVLTEDEWEETIKRIFARY---RIK-ER-------------KL-LLPDVLTYIQASGRSSRLLGSKLTKGVSILFE--TD--DAVFESLKERLD--WLTEE--EW------I-----------------DL------------ED------A-------DWETLLKEVEESRKEEK------K
>WP_014042100.1 reverse gyrase [Caldicellulosiruptor lactoaceticus]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNEKGLPCEQC-LSQ-EQ----------------------------ISKN----IFESLKKKGTL-------K----DYQ-IYW--NFQQNFDTFEKFFEHIF-QKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFL-AL-N--------G-K----KSALVFPTISLAQQS---FERLE-EF----KTKL------E-NA--NAVK-------------ILLFN-SSM--TKSRKE-AFEKRFLS-CDF-D------ILIITTQFVSKRKDV-L-SK--M-----FFDLVFVDDVDAILKS-SKNIDTLLQMIGFSE--DEIEKA-------TERLRSK-----------------------------------------NKE------------------NGQDTV-SNGSK--NK-----G-ML--IVSSAT--AKPQGL-KPLLFRELLGFEIGRFTF-NIRNITNIRI----KKKS--------------------KEKLL------------EIINILK-D---GILLFVNTEEEGKE-------IVKF---LLEN-GIKIGATWND---F---EKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFRFLI-------DM-DK--------------------APRFV----------------LE-RVFV-----------------E--------YLD-NHP-----KLK-EY---FKNVDSL-QTEKLRQLVSKYISKEDYSKIVNEIFSHL---KLT-DD-------G-----KL-VIPDVPTYIQGSGRTSRMFGMRLTKGVSILFE--ED--DTIFESLKSRLM--FLLDE--EW------M-----------------EE------------NE------V-------DFENLMEEVEESRKIQNH-----D
>WP_013430517.1 reverse gyrase [Caldicellulosiruptor kronotskyensis]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNEKGLPCEKC-LKD-DH----------------------------LTEN----VFELLKGCGLL-------K----DYQ-IYW--NFHQNYKMFEKFFELIF-HKPMTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFL-AL-N--------G-K----KSALVFPTVSLAQQS---FERLN-QF----KSKI------Q-NT--DVIR-------------ILLFN-SSM--KKSEKE-EFEQRFLS-QDF-E------ILIVTSQFVSKRKDV-L-SK--M-----FFDLVFVDDVDAILKS-SKNIDTLLQMIGFSE--DEIEKA-------TERLRSK-----------------------------------------NRE------------------NGQDTV-SNGSK--NK-----G-ML--IVSSAT--AKPQGL-KPLLFRELLGFEIGRFTF-NIRNITNIRI----KKKS--------------------KEKLL------------EIINILK-D---GILLFVNTEEEGKE-------IVKF---LLEN-SIKIGATWND---F---EKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFKFSI-------DM-DK--------------------APRFV----------------LE-RVFV-----------------E--------YLD-NHP-----KLK-EY---FKNVEIL-QTEKLRQLVSKYISKEDYSKIVNKIFSHL---KLT-DD-------G-----KL-VIPDVPTYIQGSGRTSRMFGMRLTKGVSILFE--ED--DTIFDSLKSRLM--FLLDE--EW------M-----------------EE------------NE------V-------DFESLMEEVKESRKIQND-----D
>WP_013411901.1 reverse gyrase [Caldicellulosiruptor owensensis]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNEKGLPCEKC-LED-DH----------------------------LTEN----VFELLKGRGLL-------K----DYQ-IYW--NFHQSYKMFEKFFELIF-HKPMTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFS-AL-H--------G-K----KSALVFPTISLAQQS---FEKLN-QF----KSKI------K-NA--DAIR-------------ILLFN-SSM--TKSEKE-EFEQRFLS-QDF-E------ILIVSSQFISKRKDV-L-SK--M-----FFNLVFVDDVDAILKS-SKNIDTLLQMIGFSE--DEIEKA-------TERLKNK-----------------------------------------NKE------------------NGQNTN-LNTLK--DK-----G-ML--IVSSAT--AKPQGL-KPLLFRELLGFEIGRFTF-NIRNITNIRI----KKKS--------------------REKLL------------EIINILK-D---GILLFVNTEEEGKE-------IVKF---LAEN-GVKIGTTWSN---F---DEEFELFKEGKLNVICGVSSYYGKLIRGIDLPERIKYCIFWETPSFRFSV-------DM-DK--------------------APRFV----------------LE-RVFV-----------------E--------YLE-DHP-----KLK-EY---FKNVETL-QTEKLRQLVLKYISAESYNKIVQEIFSHL---KIT-DD-------G-----KL-VIPDVPTYIQGSGRTSRMFGMRLTKGVSILFE--ED--DTIFESLKSRLM--FLLDE--EW------M-----------------DE------------SE------A-------NFESLMVEVEESRKSRNE-----G
>WP_022587101.1 reverse gyrase [Caldanaerobacter subterraneus]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNEKGLPCEVC-LPF-ED------------------------------GD----ILKGLKLNNSL-------K----GYE-KYW--NLNQQYKEFEEFFFSKI-NKKPTGYQRFWAKRLLLSKSFTLVAPTGVGKTTFGLISALWI-AK-K--------G-G----KVALVFPTVSLVEQA---AKRLI-EF----SKED------E-D-----VN-------------ILFYT-SSL--KKKERE-KFEKNFSE-GNY-D------ILVISSQFISKRKEQ-L-SQ--K-----VFDLVFVDDVDAVLKS-SKNIDTLLNMIGISQ--KAIDST-------LDNLKKG-----------------------------------------NNS------------------DKIQ---IEEKA--PK-----G-RL--IVSSAT--AKPKGI-KPLLFRELLGFEIGRFTT-SARNITNVRI----KEKS--------------------LEKLL------------YIINLLK-D---GILLFVPTEEEGKE-------IANY---LEEH-GVKLGKTWED---F---EKSFEKFKEGSLQLLCGIYSYYGKLVRGIDLPLRIKFAVFWGTPSFKFST-------KL-EN--------------------APRFI----------------LE-RNFQ-----------------D--------YLE-NNP-----KLK-AY---FKDLQRL-STEKLRKSVEKYISPETWEKLIQKNFPTT---KFD-KE-------K-----NLIVIPDVYTYIQASGRTSRIFGTSLTKGISILFE--ED--DSLFELLKARLL--YLTEE--EW------T-----------------EE------------GE------I---------EHLVKEAEETRKAIST-----D
>KUK08414.1 Reverse gyrase [Caldanaerobacter subterraneus]
------------------------------------------------------------------------MALAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNEKGLPCEVC-LPF-ED------------------------------GD----ILKGLKLNNSL-------K----GYE-KYW--NLNQQYKEFEEFFFSKI-NKKPTGYQRFWAKRLLLSKSFTLVAPTGVGKTTFGLISALWI-AK-K--------G-G----KVALVFPTVSLVEQA---AKRLI-EF----SKED------E-D-----VN-------------ILFYT-SSL--KKKERE-KFEKNFSE-GNY-D------ILVISSQFISKRKEQ-L-SQ--K-----VFDLVFVDDVDAVLKS-SKNIDTLLNMIGISQ--KAIDST-------LDNLKKG-----------------------------------------NNS------------------DKIQ---IEEKA--PK-----G-RL--IVSSAT--AKPKGI-KPLLFRELLGFEIGRFTT-SARNITNVRI----KEKS--------------------LEKLL------------YIINLLK-D---GILLFVPTEEEGKE-------IANY---LEEH-GVKLGKTWED---F---EKSFEKFKEGSLQLLCGIYSYYGKLVRGIDLPLRIKFAVFWGTPSFKFST-------KL-EN--------------------APRFI----------------LE-RNFQ-----------------D--------YLE-NNP-----KLK-AY---FKDLQRL-STEKLRKSVEKYISPETWEKLIQKNFPTT---KFD-KE-------K-----NLIVIPDVYTYIQASGRTSRIFGTSLTKGISILFE--ED--DSLFELLKARLL--YLTEE--EW------T-----------------EE------------GE------I---------EHLVKEAEETRKAIST-----D
>WP_015907632.1 reverse gyrase [Caldicellulosiruptor bescii]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCSGINTD-TRNEKGLPCEKC-LKD-DH----------------------------LTEN----VFELLKGRGLL-------K----DYQ-IYW--NFHQNYKMFEKFFEHIF-QKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFL-AL-N--------G-K----KSALVFPTVSLAQQS---FERLE-EF----KTKL------E-NA--NAVK-------------ILLFN-SSM--TKSRKE-EFEKRFIS-CDF-D------ILIITTQFVSKRKDV-L-SK--M-----FFDLVFVDDVDAVLKS-SKNIDTLLQMIGFSE--DEIEKA-------TERLRSK-----------------------------------------NRE------------------NGQDTV-SNGSK--NK-----G-ML--IVSSAT--AKPQGL-KPLLFRELLGFEIGRFTF-NIRNITNIRI----KKKS--------------------KEKLL------------EIINILK-D---GILLFVNTEEEGKE-------IVKF---LLDN-SIKIGATWND---F---EKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFRFSI-------DM-DK--------------------APRFV----------------LE-RVFV-----------------E--------YLD-NHP-----KLK-EY---FKNVEIL-QTEKLRQLVSKYISKEDYSKIVNKIFSHL---KLT-DD-------G-----KL-VIPDVPTYIQGSGRTSRMFGMRLTKGVSILFE--ED--DTIFESLKSRLM--FLLDE--EW------M-----------------EE------------NE------V-------DFESLMEEVKVSRKIQND-----D
>PBD03988.1 reverse gyrase [Caldicellulosiruptor bescii]
-------------------------------------------------------------------------MLAT-------------------------------------G-------------------------------------------------AKYYHSCINCSGINTD-TRNEKGLPCEKC-LKD-DH----------------------------LTEN----VFELLKGRGLL-------K----DYQ-IYW--NFHQNYKMFEKFFEHIF-QKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFL-AL-N--------G-K----KSALVFPTVSLAQQS---FERLE-EF----KTKL------E-NA--NAVK-------------ILLFN-SSM--TKSRKE-EFEKRFIS-CDF-D------ILIITTQFVSKRKDV-L-SK--M-----FFDLVFVDDVDAVLKS-SKNIDTLLQMIGFSE--DEIEKA-------TERLRSK-----------------------------------------NRE------------------NGQDTV-SNGSK--NK-----G-ML--IVSSAT--AKPQGL-KPLLFRELLGFEIGRFTF-NIRNITNIRI----KKKS--------------------KEKLL------------EIINILK-D---GILLFVNTEEEGKE-------IVKF---LLDN-SIKIGATWND---F---EKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFRFSI-------DM-DK--------------------APRFV----------------LE-RVFV-----------------E--------YLD-NHP-----KLK-EY---FKNVEIL-QTEKLRQLVSKYISKEDYSKIVNKIFSHL---KLT-DD-------G-----KL-VIPDVPTYIQGSGRTSRMFGMRLTKGVSILFE--ED--DTIFESLKSRLM--FLLDE--EW------M-----------------EE------------NE------V-------DFESLMEEVKVSRKIQND-----D
>WP_132040153.1 reverse gyrase [Caldanaerobacter subterraneus]
------------------------------------------------------------------------MALAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNEKGLPCEVC-LPF-ED------------------------------GD----ILKGLKLNNSL-------K----GYE-KYW--NLNQQYKEFEEFFFSKI-NKKPTGYQRFWAKRLLLSKSFTLVAPTGVGKTTFGLISALWI-AK-K--------G-G----KVALVFPTVSLVEQA---AKRLI-EF----SKED------E-D-----VN-------------ILFYT-SSL--KKKERE-KFEKNFSE-GNY-D------ILVISSQFISKRKEQ-L-SQ--K-----VFDLVFVDDVDAVLKS-SKNIDTLLNMIGISQ--KAIDST-------LDNLKKG-----------------------------------------NNS------------------DKIQ---IEEKA--PK-----G-RL--IVSSAT--AKPKGI-KPLLFRELLGFEIGRFTT-SARNITNVRI----KEKS--------------------LEKLL------------YIINLLK-D---GILLFVPTEEEGKE-------IANY---LEEH-GVKLGKTWED---F---EKSFEKFKEGSLQLLCGIYSYYGKLVRGIDLPLRIKFAVFWGTPSFKFST-------KL-EN--------------------APRFI----------------LE-RNFQ-----------------D--------YLE-NNP-----KLK-AY---FKDLQRL-STEKLRKSVEKYISPETWEKLIQKNFPTT---KFD-KE-------K-----NLIVIPDVYTYIQASGRTSRIFGTSLTKGISILFE--ED--DSLFELLKARLL--YLTEE--EW------T-----------------EE------------GE------I---------EHLVKEAEETRKAIST-----D
>WP_011025941.1 reverse gyrase [Caldanaerobacter subterraneus]
------------------------------------------------------------------------MALAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNEKGLPCEVC-LPF-ED------------------------------GD----VLKGLKLNNSL-------K----GYE-KYW--NLNQQYKEFEEFFFSKI-NKKPTGYQRFWAKRLLLSKSFTLVAPTGVGKTTFGLISALWI-AK-K--------G-G----KVALVFPTVSLVEQA---AKRLI-EF----SKED------E-D-----VN-------------ILFYT-SSL--KKKERE-KFEKNFSE-GNY-D------ILVISSQFISKRKEQ-L-SQ--K-----VFDLVFVDDVDAVLKS-SKNIDTLLNMIGISQ--KAIDST-------LDNLKKG-----------------------------------------NNS------------------DKIQ---IEEKA--PK-----G-RL--IVSSAT--AKPKGI-KPLLFRELLGFEIGRFTT-SARNITNVRI----KEKS--------------------LEKLL------------YIINLLK-D---GILLFVPTEEEGKE-------IANY---LEEH-GVKLGKTWED---F---EKSFEKFKEGSLQLLCGIYSYYGKLVRGIDLPLRIKFAVFWGTPSFKFST-------KL-EN--------------------APRFI----------------LE-RNFQ-----------------D--------YLE-NNP-----KLK-AY---FKDLQRL-STEKLRKSVEKYISPETWEKLIQKNFPTT---KFD-KE-------K-----NLIVIPDVYTYIQASGRTSRIFGTSLTKGISILFE--ED--DSLFELLKARLL--YLTEE--EW------T-----------------EE------------GE------I---------EHLVKEAEETRKAIST-----D
>WP_013403483.1 reverse gyrase [Caldicellulosiruptor hydrothermalis]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNEKGLPCEEC-LAQ-EQ----------------------------LNEN----IFESLKKKGSL-------K----HYQ-LYW--NFQQIYSMFEKFFELIF-HKPMTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFS-AL-H--------G-K----KSALVFPTISLAQQS---FERLN-QF----KSKI------Q-NA--DAIR-------------ILLFN-SSM--TKSEKE-EFEQRFLS-QDF-E------ILIVSSQFISKRKDV-L-SK--M-----FFDLVFVDDVDAILKS-SKNIDTLLQMIGFSE--DEIEKA-------TERLRSK-----------------------------------------NKE------------------NGQDTV-SNGSK--NK-----G-ML--IVSSAT--AKPQGL-KPLLFRELLGFEIGRFTF-NIRNITNIRI----KNKS--------------------NEKLL------------EIINILK-D---GILLFVNTEEEGKE-------IVKF---LLEN-GIKIGATWND---F---EKEFEFFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFRFLI-------DM-DK--------------------APRFV----------------LE-RVFV-----------------E--------YLD-NHP-----KLK-EY---FKNVEYL-QTEKLRQLVSKYISYEDYSKIVNKIFSHL---KLT-DD-------G-----KL-IIPDVPTYIQGSGRTSRMFGMNLTKGVSILFE--ED--DTIFESLKSRLM--FLLDE--EW------I-----------------DE------------SE------V-------NLESLIMEVEESRKSRNE-----D
>WP_013290690.1 reverse gyrase [Caldicellulosiruptor obsidiansis]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNENGLPCEQC-LSQ-KQ----------------------------IN-D----IYKSLKKMGTL-------K----DYQ-LYW--NFQQNLNAFKMFFEHIF-QKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFL-AL-N--------G-K----KSALVFPTISLAQQS---FERLE-EF----KAKL------E-NA--NTVK-------------ILLFN-SLM--TKSRKE-EFEKRFLS-CDF-D------ILIITTQFVSKRKDV-L-SK--M-----FFDLVFVDDVDAILKS-SKNIDTLLQMIGFSE--DEIEKA-------TERLRTK-----------------------------------------NKE------------------NGQDTV-SNGSK--NK-----G-ML--IVSSAT--AKPQGL-KPLLFRELLGFEIGRFTF-NIRNITNIRI----KKKS--------------------KEKLL------------EIINILK-D---GILLFVNTEEEGKE-------IVKF---LAEN-GIKIGTTWSN---F---DEEFELFKEEKLNVICGVSSYYGKLIRGIDLPERIKYCIFWETPRFRFSV-------DM-DK--------------------APRFV----------------LE-RVFV-----------------E--------YLE-DHP-----KLK-EY---FKNVEIL-QTEKLRQLVLKYISAESYNKIVQEIFSHL---KIT-DD-------G-----KL-VIPDVPTYIQGSGRTSRMFGMRLTKGVSILFE--ED--DTIFESLKSRLM--FLLDE--EW------M-----------------EE------------NE------V-------DFESLMEEVKESRKIQNN-----D
>PFH15103.1 reverse gyrase [Caldicellulosiruptor bescii]
-------------------------------------------------------------------------MLAT-------------------------------------G-------------------------------------------------AKYYHSCINCSGINTD-TRNEKGLPCEKC-LKD-DH----------------------------LTEN----VFELLKGRGLL-------K----DYQ-IYW--NFHQNYKMFEKFFEHIF-QKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFL-AL-N--------G-K----KSALVFPTVSLAQQS---FERLE-EF----KTKL------E-NA--NAVK-------------ILLFN-SSM--TKSRKE-EFEKRFIS-CDF-D------ILIITTQFVSKRKDV-L-SK--M-----FFDLVFVDDVDAVLKS-SKNIDTLLQMIGFSE--DEIEKA-------TERLRSK-----------------------------------------NRE------------------NGQDTV-SNGSK--NK-----G-ML--IVSSAT--AKPQGL-KPLLFRELLGFEIGRFTF-NIRNITNIRI----KKKS--------------------KEKLL------------EIINILK-D---GILLFVNTEEEGKE-------IVKF---LLDN-SIKIGATWND---F---EKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFRFSI-------DM-DK--------------------APRFV----------------LE-RVFV-----------------E--------YLD-NHP-----KLK-EY---FKNVEIL-QTEKLRQLVSKYISKEDYSKIVNKIFSHL---KLT-DD-------G-----KL-VIPDVPTYIQGSGRTSRMFGMRLTKGVSILFE--ED--DTIFESLKSRLM--FLLDE--EW------M-----------------EE------------NE------V-------DFESLMEEVKVSRKIQND-----D
>WP_012579357.1 reverse gyrase [Thermosipho africanus]
--------------------------------------------------------------------------MPV-------------------------------------N-------------------------------------------------LKFDHSCINCEKINTD-DRNLKGLPCIKC-LPN-E------------------------------TND----YINSLITTNKL-------Y----KLE-KYI--RFENEFKDFFNFFVEKT-GLKLNGYQKLWTKRVLLSKSFTMIAPTGLGKTTFGILMAIWL-AK-K--------E-K----KSILIFPTITIVKQV---VEKIK-KL----DKT---------------IK-------------VLYYN-SNM--KKSEKE-DFEKRFKK-DDY-K------ILIVSTQFISKRKEE-L-KN--K-----FFDFVFIDDVDSVLKS-SKNIETIIMLTGVPE--NIINET-------LKKLKSG-----------------------------------------QKP------------------EIKDL---------KK-----G-IL--VVSSAT--ARPKGI-RPLLFRYIFNFNLGKPSF-FSRNIIHIRY----KNKE--------------------INQLI------------ELLKILN-D---GIIIYAENENEAKK-------LKEA---LKKN-NIEAGTSWEN---F---EESFEKFKNGKLNILIGISSYYGKLVRGIDLPEKIKAVIFWGIPKFR-------------------------------------------------------------------------------------------------------------------------------------------------------IE-KE-------------DL-ILPDIYTYVQATGRTSRLFKGNLLKGASFVFE--EN--DEIFEKLSSRLF--WITDE--EF------Y-----------------NY------------ND------I-------DIKKLANELNESRKNIQ-------
>WP_126993991.1 reverse gyrase [Thermosipho globiformans]
--------------------------------------------------------------------------MPV-------------------------------------N-------------------------------------------------LKFDHSCINCEKINTD-DRNLKGLPCIEC-LPN-E------------------------------TND----YINSLITTNKL-------Y----KLE-KYI--RFENEFKDFFNFFVEKT-GLKPNGYQKLWSKRILLSKSFTMIAPTGLGKTTFGILMAIWL-AK-K--------E-K----KSILIFPTIAIVKQV---VEKIE-KL----DKT---------------IK-------------ILYYN-SNM--KKSEKE-DFEKRFKK-DDY-K------ILIVSTQFISKRKEE-L-KN--K-----FFDFVFIDDVDSVLKS-SKNIETIIMLTGVPE--NVINET-------LKKLKSG-----------------------------------------QKP------------------EIKDI---------NK-----G-IL--VVSSAT--AMPKGI-RPLLFRYIFNFNLGKQSF-FSRNIIHIRY----KAKE--------------------INQLI------------ELLKILN-D---GIVIYAENENEAKK-------LKEI---LKKN-NIEVGTSWEN---F---EESFEKFKYGKLNILIGISSYYGKLVRGIDLPEKIKAVIFWGIPKFR-------------------------------------------------------------------------------------------------------------------------------------------------------IK-KE-------------NL-ILPDIYTYVQATGRTSRLFKGNLLKGASFVFE--EN--DEIFEKLSSRLF--WITDE--EF------Y-----------------NY------------SD------I-------DIKKLVNELNESRKNIQ-------
>WP_073072845.1 reverse gyrase [Thermosipho atlanticus]
--------------------------------------------------------------------------MPL-------------------------------------G-------------------------------------------------LKYYHTCINCEGVNTD-NRNLKGLPCEKC-LPK-V------------------------------PKD----FEKTLKLNGKL-------Q----KLS-TYI--KFQKSFEDFKKFFGEKV-GSTLNGYQRIWARRVINLKSFTMVAPTGVGKTTFGITISLWL-SK-Q--------K-K----KSILILPTISLVKQV---VDKLK-RF----ESN---------------VR-------------LLFYL-SNM--KKDDKK-MFEKCFEE-DDY-D------ILVVSTQFISKRRES-L-KD--K-----YFDFVFVDDVDSVLKS-SKNIETIISLTGVSE--EILKET-------IEKIKKG-----------------------------------------EKP------------------VFGNT---------PH-----G-IL--VISSAT--AKPKGL-KPLLFRYIFNFNLGRATY-LSRNITHVRI----KEKN--------------------LKQLI------------DILKILK-D---GIVIYVSNEEEGKY-------LEGK---LKEK-GFKIGTSWEK---F---DENFERFRNKDLNILIGISSYYGKLVRGIDLPERIKFSIFWGLPKFK-------------------------------------------------------------------------------------------------------------------------------------------------------LK-DE-------------DL-IIPDFYTYVQATGRTSRLLKGNLVKGLSIVFE--EN--DDLYEKLLSRLV--WFSDE--EF------F-----------------DF------------NE------I-------DLDKLIKEVEESRMLVL-------
>RKX39946.1 reverse gyrase, partial [Thermotogae bacterium]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTGVGKTTFGMVTSLWF-SF-H--------A-K----RSAMILPTLTLVLQIRERLEGMV-KR----IDGD--------------VD-------------IIHYH-AGM--KEKEKK-EFFEKLER-GDF-H------IAIFSTQFLSKNREI-L-SK--L-----KFDFVFVDDVDAVLKS-SKNIDTILMMLGIEK--EAIEKA-------LMKLRK------------------------------------------KRE------------------EEFEIG--------EH-----G-IL--VVSSAT--ARPKGI-RPLLFRELLGFDVGTLVV-GVRNITNLRV----KSED--------------------TDDLL------------DLLEKLK-D---GIVLLARDEKTIKW-------LSEI---VEGA-GFPVGKSWEN---L---EKALEDFSEGKVSIIAGVYSYYGKLVRGLDLPKRVKFVIFWGTPVFEYFI-------DM-EK--------------------APRFV----------------IR-RVLF-----------------E--------VSK-KNT-----KVK-KL---LQIVDRS-DIETLRNRLKVVLTEDEWEETIKRIFARY---RIK-ER-------------KL-LLPDVLTYIQASGRSSRLLGSKLTKGVSILFE--TD--DAVFESLRERLD--WLTEE--EW------I-----------------DL------------ED------A-------DWETLLKEVEESRKEEK------K
>HAA82695.1 reverse gyrase [Thermotoga naphthophila]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LLE-E-----------------------------SPSD----IYRALLERKTL-------K----EYR-FYH--DFWNEYEDFRSFFKKKF-GKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWL-AG-K--------G-K----KSALIFPTVALVKQT---LERLQ-KF----SDEK--------------VK-------------ILGFY-SSM--KKEEKE-KFEKGFEE-DDY-H------ILVFSTQFVSKNREK-L-SQ--K-----RFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--EIIRKA-------FSTIKQGK--------------------------------------IYERP------------------KSLKP----------------G-IL--VVSSAT--AKPRGI-RPLLFRDLLNFTVGRLVS-VARNITHVRI----STRS--------------------KEKLI------------ELLEIFR-D---GILIFTQTEEEGKE-------LYEY---LKRF-KFNVGETWSE---F---EKNFEDFKVGKLNILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSL-------EF-DR--------------------APRFV----------------LA-RVLK-----------------E--------MGL-IKA-----Q------------ENP-DVEELRKIAKEHLTQKEFVEKVKEMFRGV---VVK-DE-------D----LEM-TIPDVYTYIQASGRSSRILNGVLVKGVSVIFE--ED--EEIFESLKTRLL--LIAEE--EI------I-----------------EE------------SE------T-------NWKELVHEVEES------------
>HCF37691.1 reverse gyrase [Thermosipho africanus]
--------------------------------------------------------------------------MPV-------------------------------------N-------------------------------------------------LKFDHSCINCEKINTD-DRNLKGLPCIKC-LPN-E------------------------------TND----YINSLITTNKL-------Y----KLE-KYI--RFENEFKDFFNFFVEKT-GLKLNGYQKLWTKRVLLSKSFTMIAPTGLGKTTFGILMAIWL-AK-K--------E-K----KSILICPTITIVKQV---VEKIK-KL----DKT---------------IK-------------VLYYN-SNM--KKSEKE-DFEKRFKK-DDY-K------ILIVSTQFISKRKEE-L-KN--K-----FFDFVFIDDVDSVLKS-SKNIETIIMLTGVPE--NIINET-------LKKLKSG-----------------------------------------QKP------------------EIKDL---------KK-----G-IL--VVSSAT--ARPNGI-RPLLFRYIFNFNLGKPSF-FSRNIIHIRY----KNKE--------------------INQLI------------ELLKILN-D---GIIIYAENENEAKK-------LKEA---LKKN-NIEAGTSWEN---F---EESFEKFKNGKLNILIGISSYYGKLVRGIDLPEKIKAVIFWGIPKFR-------------------------------------------------------------------------------------------------------------------------------------------------------IE-KE-------------DL-ILPDIYTYVQATGRTSRLFKGNLLKGASFVFE--EN--DEIFEKLSSRLF--WITDE--EF------Y-----------------NY------------ND------I-------DIKKLANELNESRKNIQ-------
>RLF25233.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------------MH----------------------------------------------------------------------------------------AIFEGLCPNCGGEIAD-DRLMMCLPCRRC-LPD-DKAQ-ELIK-LY--GK---------IPLLEFKKK----VVEYLGK--NL-------K----NYV-KVV--ELDEKLKDVDLLFHKAT-GSYLWSAQRTWAKRVLEGKSFAIIAPTGVGKTMFGMVISLFL-AR-N--------G-K----RCYIVLPTSVLVKQV---YDRIV-DI----SKR-------A-NI---NAK-------------IIAYL-PRM--SKEEKE-NFKESLEK-GDF-D------VLITTSQFLARKFDE-L-KG--L-----KFDFIFVDDVDALLKS-SKNIDRVLMLLGVSE--ELIERS-------MELVRLKR---HLAFLSATARRD--------EEY-RRQ-LEE----LINK-------V-----------RELSDDIRRSLE--GK--E-LG-VL--VVSSAT--GRPRGL-RVRLFRELLGFEVGSRSE-FIRNIQDMYH----IPRA-D----------------M-KEEVL------------KIVKLFG-D---GGLVFVPLDKGVEY-------AEELASYLKEH-GVRAEVLTAK--KK---SDQIERFVEGELDVLIGVATYYGLLVRGLDLPHRVRYAVFAGVPKLRFSL-------EA-KE-AHPFRIASLLSDLREY-L-EGK------EKDEV-ERLVALMM-RYL--RELPAA---RIQELK-E--------AME-QGV-----KLS-GR----MQRIQE-IFEKGLEKVRELLSREDIRRKISES-PYI---TLE-ET-------PEG--LKV-IIPDVMTYIQASGRTSRMFAGGISRGASIVIV--DD--KKVFEGLVRKSR--WIVED-IEW------K-----------------AL------------EE------V-------NIKELIDEIDRDRNIIKML-RE-G
>RLE54014.1 reverse gyrase [Candidatus Verstraetearchaeota archaeon]
--------------------------------------------------------------------MINE--IH----------------------------------------------------------------------------------------GIYGHACPNCGGREED-LRLLMKLPCSRC-LP--K-IP-DKGR----------------L----SIDE----IYEILKRSGRV-------K----NYG-RIY--EFERKYREFEKLFRKAT-GSRPWSVQRTWARRVLMDKSFTIVAPTGIGKTLFGMIISLYQ-AW-R--------H-G----KAYILTPTTPLTEQI---YEKCS-KY----AEK-------A-GL---NVK-------------ILRYH-ANL--NRSEKK-KILEDIAK-GDF-N------LLITTSKFLSIHHGK-L-EN--L-----KFRLIFVDDVDAILKS-SRNIERILKLMGYTE--EEISTA-------FELIKTKS---RIS--S-LIRIR-------FR---GKE-LKD----LMDK-------Y-----------RRLEERIRRIGR------K-NS-IL--IVSTAT--GRPRGL-RVKLFRELLGFDVGARSE-LLRNVVDAYLT--VRDEV-----------------EL-EGKLK------------ELVERLG-D---GGLIFIPIDRGVEY-------AERIVNFLEKN-GVKAELFTSK---N---LKALEKFRRGEVQILVGISYYYGVMVRGLDLPERVRYAVFLGVPKFKFST-------QL-ED-PHPLKIFRALTILQEV---EEE------RRGEI-QRIIGKLR-RYL--AMMTIQ---RINNLR-E--------MLA-GEV-----KVE--------NPVAR-AFGEALKLVREEFSRDEIKKRLDQL-EDV---RIT-VE-------KDK--TYI-AIPDVMTYIQASGRTSRMYAGGLTKGLAVTIA--LD--EKLLKGLMRRTR--WINEE-MTW------K-----------------KL------------EE------V-------NLNSILDEIDEDRRRIREI-LE-G
>WP_012571288.1 reverse gyrase [Thermococcus onnurineus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AVYREMCPNCLGRISD-ERLCLKNPCNEC-L-----DE-TAHA----------------DSYFELITA----VRNALQLKGTL-------K----EWE-RIY--ELESGVREVEAFFENAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMALWH-AT-K--------G-K----KSYIVVPTTPLVIQT---VKKIQ-AI----AEK-------S-GV---QIN-------------LAYYH-GNL--RKKEKE-EMLAKIEN-DDY-Q------ILVTSAQWLARNFDEKL-KG--R-----RFDFIFVDDVDAFLKA-SKNIDRSLLLLGFTE--EVINKA-------WEIIRLKK---SMA---KYINGR-AEDRD-------ER-LKE----LNRE-------I-----------EKLQREIEEFKE--KN--G-VG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVVDSYL----MPTK-----------------DI-KEHVE------------ELLTRLG-K---GGIIFTPIDQGLAY-------AEELVNYLRGK-GFRIELVSSK---N---KKAIERFEKGEADYLIGSATYYGSLVRGLDMPHLIRYAVFTGVPKFRFSI-------DL-ER-PTIYRALGLLTEVMDF-L-NDE------QRREA-EKLHARLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PIDNSF----HNHVLN-VFRELVEFLRKVLRDEEVLRKLAED-PFI---SLK-EE-------GGK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKVFNGLVRQMR--WRFTE-FKM------T-----------------PF------------EE------L-------NLDEILRQIDEDREKVRLV-ME-G
>WP_015859292.1 reverse gyrase [Thermococcus gammatolerans]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------ALYREMCPNCGGRISD-ERLYMRNPCESC-L-----NE-PIVV----------------DSYFELVSA----VRDALLKANRL-------K----EWE-RIY--RLESESREIEDFFKKAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMSVYY-AT-K--------G-K----KSYIVVPTTPLVIQT---IRKVQ-AI----IER-------T-GL---DVK-------------LAYYH-GNL--RKKEKE-EMLAKIEG-GDY-D------ILITSAQWLARNFDEKL-KG--R-----HFDFIFVDDVDAFLKA-SKNIDRSLLLLGFTE--EIIGKA-------WEIIRLKK---QMA---RYLNGN-SEDKN-------DR-LKE----LNEA-------I-----------EKLQREIEEFKR--KN--D-IG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVVDSYL----KPSK-----------------DV-KEHVE------------ELLRKLG-K---GGLIFVPIDQGLSY-------AEELVNYLREK-GFAVELASSK---N---KKAVERFENGEADYLVGVATYYGSIVRGLDLPHLIRYAVFTGVPKFRFSI-------DL-ER-PTIYRALGLLGEVMDF-L-DDE------DRKTA-EKLHARLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PIENDF----HKTVLN-VFRELVEFLREVLKKEDVLRRLAED-PFV---SLV-KE-------EGK--WFI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKVFNGLVRQMR--WRFTE-FKM------V-----------------PF------------EE------L-------DLEKLLKEIDEDREKVKLV-ME-G
>WP_099210150.1 reverse gyrase [Thermococcus sp. EXT12c]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREACPNCSGRISD-ERLVMKNPCDEC-L-----DN-PVTA----------------EDYFELVKA----VRKALKERKKL-------K----AWE-EIY--SLEKGLRDVEKFFEKAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMSVYY-AT-K--------G-K----KSYIVVPTTPLVIQT---IKKVQ-AI----IER-------T-GL---DIN-------------LAYYH-GNL--RKKEKE-EMLAKIEG-EDY-D------ILITSAQWLARNFDEKL-KG--R-----HFDFIFVDDVDAFLKA-SKNIDRSLLLLGFTE--EIIGKA-------WEIIRLRK---QMS---RYLNGR-AQDRE-------EK-LKE----LNEA-------I-----------EKLQHEIEEFKR--KN--D-IG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVVDSYL----KPSG-----------------DV-KEHVA------------ELLRKLG-K---GGLIFVPIDQGLSY-------AEELVNYLKER-GFAVELASSK---N---KKAVERFENGEADYLVGVATYYGSIVRGLDLPHLIRYAVFTGVPKFRFSI-------DL-ER-PTIYRALGLLSEVMDF-L-DDE------DRRKA-EKLHARLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PIENDF----HRTVLN-VFRELVEFLREVLKKEDVLKRLAED-PFV---SLV-KE-------EGK--WFI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKVFNGLVRQMR--WRFTE-FKM------V-----------------PF------------EE------L-------DLEELLREIDEDREKVRLV-ME-G
>RLE51953.1 reverse gyrase [Candidatus Verstraetearchaeota archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIFENACPNCGGPIDD-ERLMLAAPCRNC-LDI-P-DE-QLKQ-LMSS------------NLLDYRKK----IVELLEQRGTL-------Q----KYA-EVE--LFEREIADFKEMAKKAL-GVDLWDAQVNWACKALSGKSFAITAPTGLGKTTFGLLYALRM-AM-H--------G-R----KCYVMVPTSILVEQA---KKKLD-DY----SVK-------I-GV---NVR-------------ILCYH-AGI--KGEERE-AIWKAIES-GDF-D------ILVTTSQFLARYFEK-L-KG--I-----RFDLAFVDDVDALLKA-SKNIERVLQLLGFTP--KIIETA-------LDVIKAKR---WLT---ARAGKE--------EG------SEV----QLRI-------I-----------REGQEEIERFKR--EN--K-VG-ML--IVSTAT--GKPRGL-RVKLFRELLGFEVGSKAE-QIRNVADLYV-----PQVAD----------------L-KIMVA------------ELVQRLG-G---GGLIYVPMDMGIDY-------AEHIAGYLREC-GIRAEVFYSK---E---KKRLEDFVNGEIEVLVGVANYYGLLVRGIDLPQRIRYAIFAGVPRIRFSL-------AV-EE-ASPMRVLQLLIELREV-L-EGD------EKKKA-EAMIARLS-R-------------DMDVLQ-V--------LIK-RIE-----GLT-SR----QKLVLR-RFEEAKEFVSSLLRRSDIRRKLEEN-PYV---SIK-EI-------EGK--LYI-VIPDAPTYIQASGRTSRVFAGGISKGISIVIV--DD--EKVFSGLVRKTK--WMSEE-IEW------R-----------------KL------------SE------V-------DLDELVKEVDKDRKLISDI-LA-G
>WP_042689032.1 reverse gyrase [Thermococcus nautili]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREACPNCSGRISD-ERLVMKNPCDEC-L-----DN-PVTA----------------EDYFELVKA----VREALKERKKL-------K----AWE-EIY--SLEKGLRDVEKFFEEAT-GFRFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMSVYY-AT-K--------G-K----KSYIVVPTTPLVIQT---IRKVQ-AI----IER-------T-GL---SVN-------------LAYYH-GNL--RKKEKE-EMLVKIES-GDY-D------ILITSAQWLARNFDEKL-KG--R-----HFDFIFVDDVDAFLKA-SKNIDRSLLLLGFTE--EIIGKA-------WEIIRLKK---QMS---KYLNGR-AEDRD-------ER-LKE----LNEA-------I-----------EKLQREIEEFKR--KN--D-IG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVVDSYL----KPSK-----------------DV-KEHVE------------ELLRKLG-K---GGLIFVPIDQGLGY-------AEELVNYLRER-GFAVELASSK---N---KKAVERFENGEADYLVGVATYYGSIVRGLDLPHLIRYAVFTGVPKFRFSI-------DL-ER-PTIYRALGLLGEVMDF-L-DDE------DRKTA-EKLHARLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PIENDF----HKTVLN-VFRELVEFLREVLKKEDVLKRLAED-PFV---SLV-KE-------EGK--WFI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKVFNGLVRQMR--WRFTE-FKM------V-----------------PF------------EE------L-------DLEKLLKEIDEDREKVRLV-ME-G
>RLE49788.1 reverse gyrase [Candidatus Verstraetearchaeota archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIFENACPNCGGPIDD-ERLMLSAPCRNC-LDI-P-DE-QLKQ-LMSS------------NLLDYRKK----IVELLEQKGTL-------Q----KYA-EVE--LFEREVADFKETAKKAL-GVDLWDAQVNWACKALSGKSFAITAPTGLGKTTFGLLYALRM-AM-R--------G-K----KCYVMVPTSVLVEQA---RKKLD-DY----SAK-------I-GV---NVR-------------ILCYH-AGI--KGEERE-AIWKAIES-GDF-D------ILVTTSQFLARYFEK-L-KG--I-----RFDLVFVDDVDALLKA-SKNIERVLQLLGFTP--KIIETA-------LDVIRAKR---WLT---ARAGKE--------EG------SEV----QLKI-------I-----------REGQEEIERFKR--EN--K-VG-ML--IVSTAT--GKPRGL-RVKLFRELLGFEVGSKAE-QIRNVADLYV-----PQVAD----------------L-KIMVA------------ELVQRLG-G---GGLIYVPMDMGIDY-------AEHVAGYLREC-GIRAEVFYSK---E---KKRLEDFVNGEIEVLVGVANYYGLLVRGIDLPQRIRYAIFAGVPRIRFSL-------AV-EE-ASPMRVLQLLIELREV-L-EGD------EKKKA-EAMIARLS-R-------------DMDVLQ-V--------LIK-KVE-----GLT-SR----QKLVLR-RFEEAKEFVSSLLRRSDVRRKLEEN-PYV---SIK-EI-------EGK--LYI-VIPDAPTYIQASGRTSRVFAGGISKGISIVIV--DD--EKVFSGLVRKTK--WMSEE-IEW------R-----------------KL------------SE------V-------DLDKLVKEVNKDRKLISDI-LA-G
>WP_068666330.1 reverse gyrase [Thermococcus piezophilus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AVYREMCPNCVGRISD-ERLCSKNPCDEC-L-----PE-AVHA----------------NSYLELVTA----VRNALKLRGTL-------K----AWE-ELY--QVESQTHEIEEFFEKAT-GFTFWSAQRTWVKRLVRGRSFSIIAPTGMGKSTFGAFMAVWH-AT-K--------G-K----KSYIVVPTTPLVIQT---VKKIE-KI----AEK-------A-GI---EVN-------------LAYYH-GNL--RKKEKE-EMVTKIQN-EDY-D------ILVTSAQWLARKFDEVL-KG--R-----HFDFTFVDDVDAFLKA-SKNIDRSLLLLGFTE--EIIQKA-------WEIIRLKK---SMA---RYLNGR-AEDRD-------EK-LKE----LNEE-------I-----------EKLQREIEEFKA--RN--N-VG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-SLRNVVDSYL----KPSK-----------------DT-KEQVE------------ELLSRLG-R---GGIIFTPIDQGLAY-------AEELANYLKEK-GFRVELVSSK---N---KKAIERFENGEADYLIGSATYYGSLVRGLDLPHLIRYAIFTGVPKFRFSV-------DL-ER-PTIYRALGLMSEIIDF-L-SDE------HRKEA-EKLHARLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PIEGGF----QNHVLD-VFRQIVEFLRRVLKDREVLRKLAED-PFI---SLK-EE-------GGK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKVFNGLVRQMR--WRFTE-FKM------V-----------------PF------------EE------L-------NLEEILRQIDEDREKVRLV-MA-G
>WP_058946101.1 reverse gyrase [Thermococcus sp. 2319x1]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCEGSISD-LRLYRKHPCEVC-L-----DE-EIKA----------------EVYFDLIKG----IRDALKLRGTL-------K----YWE-ELY--SLEKKLNEAEELFKKAT-GFTFWSAQKTWVKRLVRGKSFSIIAPTGMGKSVFGAFMSIYY-AK-Q--------G-K----KSYIILPTTPLVIQT---IKRVQ-TF----AEK-------A-GV---SVN-------------LAYYH-GNM--KKKEKD-EMLQKIQS-GDF-D------ILITSTQYLARNFE-LL-KD--K-----RFDFIFVDDVDAFLKA-SKNIDRSLILLGFTE--EIIQKA-------WEIIKLKK---QMA---KYLNGN-SNGKN-------EQ-LKE----LNKQ-------I-----------NAVEREIIKFKR--EN--K-IG-VL--IVASAT--GSARGD-RIKLYRELLDFEVGSGRS-ALRNVVDSYI----FPEK-----------------PI-EEHVK------------ELLKTLG-P---GGLIFVPIDQGIAY-------AEKLTNYLQDL-GFKVELVSAR---N---KKGLERFEKGEVDYLIGVATYYGSIVRGLDLPHLIRYAIFTGVPKFRFSI-------DL-EQ-PTIYRVLGLMSELMEF-L-ENE------NRRNA-EKLYARLR-RLI--RNIPQF---EILKIE-E--------ALA-EGL-----PLE-GF----SNHVLE-VFREAVEFLRSVLRKPEVLKRIKED-PFV---SLK-KE-------EGK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVVIV--DN--EKVFNGLKRQMR--WRFAE-FEM------K-----------------PF------------TE------L-------SLEEILKEIDADREKVKLI-ME-G
>WP_013748907.1 reverse gyrase [Pyrococcus sp. NA2]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCGGAITD-ERLSSKNPCEGC-L-----AE-PIVL----------------QDYDKLIEA----IRNALKLRDTL-------K----DWE-ELY--RLNKEVSEVEELFERAT-GFRFWSAQRTWVKRIIRGKSFSIIAPTGMGKSTFGAFISIYF-AT-K--------G-K----KSYIVVPTTPLVIQT---VKKIK-AM----LER-------A-KL---NVN-------------LVYYH-GNL--KKKEKE-EALEKIRN-GDF-D------ILVTSSQFLATRFDELL-RD--K-----RFDLIFVDDVDAFLKA-SKNIDRSLLMLGFSE--EMINKA-------WEIIKLKK---QLA---KLLQNE-GK--E-------EE-VEK----LNRE-------I-----------EKAEREIEAYKK--NN--N-IG-IL--IVASAT--GTARGD-RIKLYRELLGFEVGSGRS-VLRNIVDTYL----IPEK-----------------SI-EEHVE------------ELLRKLG-K---GGLIFVPIDRGIEY-------AEKLTEYLKKK-GFRVELVSAK---S---KKGIELFENEEVDYLVGVATYYGTIVRGLDLPHLVRFAIFTGVPKFRFSM-------DL-EQ-PTIYRVLGLMSEILEF-L-PED------KRAEG-EKLYARLR-RLI--RNIPQY---ELMKIE-E--------ALA-EGL-----ELE-GF----YNHVLE-VFKSAVEFLRAVLKDEEVIKRIAEN-PFL---SLK-EI-------EGK--LYI-EIPDVRTYIQASGRTSRLFAGGITKGLSVVIV--DD--EKVFNGLLRQMR--WRFVE-FEM------K-----------------RF------------DE------V-------DIDDVLREIDEDRKKVRMV-IE-G
>WP_062387477.1 reverse gyrase [Thermococcus peptonophilus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCWGRISD-ERLLMRNPCDEC-L-----DE-PVHA----------------DSYFQLVSA----VRNALKLRGTL-------K----EWE-RIY--QLENQTREIEEFFRKAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWH-AL-K--------D-K----KSYIVVPTTPLVIQT---VRKIE-AI----MEK-------A-NA---DVR-------------LAYYH-GNL--RKKEKE-EMLEKIKN-EDY-D------ILVTSAQWLARNYEEVL-KG--R-----HFDFIFVDDVDAFLKA-SKNIDRSLYLLGFTD--EIIQKA-------WEIIRLKK---QMS---KYLNGN-SEDRN-------EK-LNG----LTRE-------I-----------EKLQREIEKFKR--KN--K-IG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVVDSYL----KPTK-----------------DI-KEHVE------------ELLSRLG-K---GGLIFVPVDQGLGY-------AEELANYLRER-GFRIELVSSK---N---KKALEKFENGEADYLIGSATYYGSLVRGIDLPHLIRYAVFTGVPKFRFSI-------DL-ER-PTIYRALGLLSEIMDF-L-SDK------DRRTA-EKLHARLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PIENEF----HNHVLG-VFRELVEFLRRVLRDEEVLRKLAED-PFI---SLT-KE-------EEK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKVFNGLVRQMR--WRFQE-FKM------V-----------------PF------------EE------L-------DLDEILRQIDEDREKVRLV-ME-G
>WP_088884595.1 reverse gyrase [Thermococcus gorgonarius]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCEGRISD-DRLVMKNPCKEC-L-----DE-PVHA----------------DSYFQLVSA----VRNALKLRGTL-------K----EWE-RIY--QLESNTREIEELFNKAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMSLWH-AK-R--------G-K----KSYIIVPTTPLVIQT---VKKIE-AM----RER-------L-GL---NVK-------------LAYYH-GNL--RKKEKE-EMLALIDS-GEY-D------ILVTSAQWLARNFEDKL-KG--R-----HFDFIFVDDVDAFLKA-SKNIDRSLYLLGFNE--ETIQKA-------WEIVRLKK---GMA---RYLNGN-SEDKN-------EK-LKE----LNEQ-------I-----------EKIQREIESYKR--KN--R-IG-VM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVVDSYL----KPTK-----------------DV-KEHVA------------DLLERIG-R---GGLIFVPIDQGLSY-------AEELVNYLRER-GFKVELASSK---N---KKAVERFENGEAEYLVGVATYYGSIVRGLDLPHLIRYAVFTGVPKFRFSI-------DL-ER-PTIYRALGLLSEVMDF-L-SDE------DRRTA-EKLYSRLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PIENEF----HNHVLG-VFRELVEFLRRVLHDKEVLKKLAED-PFV---SLT-EE-------EGK--WFI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLLV--DN--EKVFNGLVRQMR--WRFTE-FKM------V-----------------PF------------EE------L-------DLDEVLRQIDEDREKVKLV-ME-G
>WP_013905419.1 reverse gyrase [Pyrococcus yayanosii]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCEGRISD-ERLSMKNPCESC-L-----DE-PVGE----------------QVYFDLIKA----VRDALKLKGTL-------K----EWE-EIY--KLNKAVKDVEKFFEKAT-GFTFWSAQKTWVKRLVRGRSFSIIAPTGMGKSTFGAFMAIYF-AQ-K--------G-K----KSYIVVPTTPLVIQT---VRKIR-TM----AER-------A-GV---EVN-------------LAYYH-GNL--KKKEKE-DMLAKIRD-GNF-E------ILVTSSQFLATRFDELL-KD--K-----KFDFIFVDDVDAFLKA-SKNIDRSLILLGFTE--DVIAKA-------WEIIKLKK---QLA---KLLQRG-NI----------ED-IER----LNSQ-------I-----------ERLEEEIEAFRQ--KN--N-VG-VL--IVASAT--GSARGD-RIKLYRELLGFEVGSGKS-VLRNVVDSYL----IPEK-----------------PV-EDVVA------------ELLQKLG-K---GGLIFVPIDKGIEY-------AEKLTEFLKER-GFRVELVSAR---S---KKGLELFERGEVDHLVGVATYYGTIVRGLDLPHLIRFALFTGIPKFRFSL-------DL-EQ-PTIYRVLGLMSEIIEF-L-PEE------DRRTG-EKLYSRLR-KII--RNVPQF---ELMKIE-E--------ALA-EGL-----PLE-GF----QNHVLE-IFREAVEFLRRVLKNEIVLKKIAED-PFL---SLK-RE-------GDK--WFI-EIPDVRTYIQASGRTSRLFAGGITKGLSVLIV--DD--EKVFNGLVRQMR--WRFTE-FKM------I-----------------PF------------EE------L-------DLEEVLKEIDEDREKVKLV-ME-G
>WP_088180063.1 reverse gyrase [Thermococcus sp. 5-4]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCLGKISD-ERLYLKNPCNEC-L-----DE-TAHA----------------DSYFDLVTA----VRNALQLRGTL-------K----EWE-RIY--GLEKGLREIEAFFEKAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWH-AT-R--------G-K----KSYIVVPTTPLVIQT---AKKLQ-AI----AER-------A-GV---EIN-------------LAYYH-GNL--RKKERE-EMLAKIQN-EDY-D------ILVTSAQWLARKFDEVL-KG--R-----RFDFIFVDDVDAFLKA-SKNIDRSLLLLGFND--EVIEKA-------WEIIRLKK---QMS---KYLNGR-AQDRE-------ER-LKE----LNGN-------I-----------GKLQREIEEFKA--KN--G-VG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVVDSYL----KPSK-----------------DI-KEHVE------------ELLERLG-K---GGIIFTPIDQGLAY-------AEELANYLRER-GFRVELVSSK---N---RKSIEKFENGEADYLIGSATYYGSLVRGLDLPHLIRYAVFTGVPKFRFSI-------DL-ER-PTIYRALGLLSEVMEF-L-SDE------DRKQA-EKMHARLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PIENGF----HNHVLG-VFRELVEFLRRVLKDEEVLRRVAED-PFI---SLK-EE-------EGK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKVFNGLLRQMR--WRFTE-FKM------V-----------------PF------------EE------L-------DLDEVLRQIDEDREKVRLV-ME-G
>RLE61660.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------VIYDLSCPNCKGRNEY-DRIYLGVPCSSC-LPL-S-IE-KIKELRRTC-----------ESDIEFRRR----VYDMLKQYGTL-------K----YYE-DIV--KFDEKINDFSRFFEKAL-GNRPWSAQLTWAKRVFKRKSFAILAPTGVGKTVFGILMSLYL-AK-S--------G-Q----KCYIILPTTILVKQV---LEKMV-KF----SSN-------L-GL---NVD-------------IAYYY-TGM--KKAEKN-EMMKKITE-GNF-S------ILITTSKFLSRNFEK-I-RE--N-----KLEFIFVDDVDALLKS-SRNIDRVLMLLGFSQ--EIIGYA-------LKIIELKM---VIV---KYLMRR--------KNV-----PPE----ISRE-------L-----------NELREKVEKYIS--SNSEK-LG-VL--VVSTAT--GRVRGI-RPRLFRELLGFDVGSRAE-LLRNIVDVYL-------KPK-------------KGVT-FDIVD------------SLVRQLG-T---GGLIFVPVDKGISY-------AEKLHEYLSSK-GLKVGIVHAG---K---KEDLDKFINCEIDVLIGVAIYYGLLVRGIDLPQRVRYAIFVGVPRFKFTL-------SL-ED-TNPIRLMQIAMNIRDY-L-TED------LAKQI-DVIIAKMR-NVM--IELPGE---ALQLLA-E--------ATE-KGL-----QLR-GK----LLFLKN-LSVKLQELLTYAFQNEEVLENIRQS-PYL---YLE-RR-------NSE--LYL-YVPDTMTYLQASGRTSRMYAGGITKGLSLVIV--DN--DKLLNGLIRQTK--WYSEE-ISW------K-----------------SL------------DE------I-------NLEKILEEIDEDRKKVQLV-LS-G
>AAB49283.1 reverse gyrase [Pyrococcus furiosus DSM 3638]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRDMCPNCRGAITD-ERLAAKNPCDAC-L-----DE-PISM----------------DDYFQLVTA----IRKALKLKGVL-------K----EWE-EIY--ALNKEVKEIEELFKKAT-GFTFWSAQRSWVKRIIKGKSFSIIAPTGMGKSTFGAFMSIYF-AL-K--------G-K----KSYIVVPTTPLVVQT---VKKIK-AM----MEK-------A-EV---KVN-------------LVYYH-GNL--KKKEKD-EALEKIKS-GNF-D------ILVTSSQFLATRFDELL-KD--K-----RIDFMFVDDVDAFLKA-SKNIDRSLMMLGFNE--EIIKKA-------WEIIKLKK---QLA---KLLQNE-SG--N-------EE-VEK----LNRE-------I-----------ERLEREIDRYKK--EN--K-IG-IL--IVASAT--GSARGD-RIKLYRELLGFEVGSGRS-VLRNIVDTYI----IPEK-----------------SM-EEHVE------------ELLKTLG-R---GGLIFVPIDKGIEY-------AEQLTNYLKSK-GFKVELVSAR---D---KKGLELFEKEEVDYLVGVATYYGTIVRGLDLPHLVRFAIFTGVPKFRFSL-------DL-EQ-PTIYRVLGLMSEILEF-L-PEE------KRTEG-EKLYARLR-RLI--RNIPQY---ELMKIE-E--------ALA-EGL-----ELE-GF----YNHVLE-VFKQAVEFLREALKDEEVLKKIAEN-PFL---SLK-QI-------EGK--WYI-EIPDVRTYIQASGRTSRLFAGGITKGLSVILV--DD--QKVFNGLIRQMR--WRFVE-FEI------K-----------------PL------------GE------I-------NIEEVLKEIDRDREKVRLV-LE-G
>WP_050003023.1 reverse gyrase [Thermococcus eurythermalis]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------ALYREMCPNCSGRISD-ERLVMKNPCDDC-I-----DN-PVTA----------------ESYFELVNA----VREALKSRGKL-------K----AWE-DIY--SLEKGLREIEEFFEKAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMSVYY-AV-Q--------G-K----KSYIVVPTTPLVVQT---VKKVQ-AI----IER-------T-GL---DVK-------------LAYYH-GNL--KKKEKE-EMLAKIES-GDF-D------ILITSAQWLARNFDEKL-RG--K-----RFDFIFVDDVDAFLKA-SKNIDRSLLLLGFTE--GIIDKA-------WEIIRLKK---QMS---KYLNGN-AEDRE-------EK-LNE----LNGD-------I-----------GKLQREIEEFKR--KN--K-VG-VM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVVDSYL----KPTK-----------------DV-KEHVG------------ELLRRLG-K---GGLVFVPIDQGLSY-------AEELVNYLKEK-GFAVELASSK---N---KKAVEKFENGEADYLVGVATYYGSIVRGLDLPHLIRYAVFTGVPKFRFSI-------DL-ER-PTIYRALGLLSEIMDF-L-DEE------DRKQA-EKLHARLR-RLI--RNIPQF---ELMKIE-E--------ALA-EGL-----PLENDF----HKTVLN-VFRELVEFLRRVLKKEDVLQRLAED-PFV---SLV-KE-------EGK--WFI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKVFNGLVRQMR--WRFTE-FKM------V-----------------PF------------EE------L-------DLEELLREIDEDREKVRLV-ME-G
>WP_011011612.1 reverse gyrase [Pyrococcus furiosus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRDMCPNCRGAITD-ERLAAKNPCDAC-L-----DE-PISM----------------DDYFQLVTA----IRKALKLKGVL-------K----EWE-EIY--ALNKEVKEIEELFKKAT-GFTFWSAQRSWVKRIIKGKSFSIIAPTGMGKSTFGAFMSIYF-AL-K--------G-K----KSYIVVPTTPLVVQT---VKKIK-AM----MEK-------A-EV---KVN-------------LVYYH-GNL--KKKEKD-EALEKIKS-GNF-D------ILVTSSQFLATRFDELL-KD--K-----RIDFMFVDDVDAFLKA-SKNIDRSLMMLGFNE--EIIKKA-------WEIIKLKK---QLA---KLLQNE-SG--N-------EE-VEK----LNRE-------I-----------ERLEREIERYKK--EN--K-IG-IL--IVASAT--GSARGD-RIKLYRELLGFEVGSGRS-VLRNIVDTYI----IPEK-----------------SM-EEHVE------------ELLKTLG-R---GGLIFVPIDKGIEY-------AEQLTNYLKSK-GFKVELVSAR---D---KKGLELFEKEEVDYLVGVATYYGTIVRGLDLPHLVRFAIFTGVPKFRFSL-------DL-EQ-PTIYRVLGLMSEILEF-L-PEE------KRTEG-EKLYARLR-RLI--RNIPQY---ELMKIE-E--------ALA-EGL-----ELE-GF----YNHVLE-VFKQAVEFLREALKDEEVLKKIAEN-PFL---SLK-QI-------EGK--WYI-EIPDVRTYIQASGRTSRLFAGGITKGLSVILV--DD--QKVFNGLIRQMR--WRFVE-FEI------K-----------------PL------------GE------I-------NIEEVLKEIDRDREKVRLV-LE-G
>WP_068577684.1 reverse gyrase [Thermococcus chitonophagus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCNGAITD-NRLANKNPCDAC-L-----DE-PEVH----------------EDYFELITA----IRNALKLRGTL-------K----EWE-KIY--RLNKEVKDVEEFFKKAT-GFTFWSAQRTWVKRIIKGKSFSIIAPTGMGKSTFGAFISIYF-AI-K--------G-K----KSYIVVPTTPLVIQT---VKKIK-GM----IEK-------A-GV---SVN-------------LVYYH-GNL--KKKEKE-EALEKIKS-GDF-D------ILVTSSQFLATRFDELL-KD--K-----HFDLIFVDDVDAFLKA-SKNIDRSLLMLGFNN--EIIGKA-------WEIIKLKK---QLA---KLLSKE-NS--S-------EE-VEK----LNKE-------I-----------ERLERGIERYKR--EH--E-IG-IL--IVASAT--GSAKGD-RIKLYRELLGFEVGSGRS-VLRNIVDTYI----LPEK-----------------GM-EEHVV------------ELLEKLG-K---GGLIFVPIDKGIEY-------AEQLTNYLKER-GFKVELVSAK---N---KKGLELFEQEKVDYLVGVATYYGTIVRGLDLPHLIRFAIFTGVPKFRFSL-------DL-EQ-PTIYRVLGLMSEILEF-L-PEE------KRSEG-EKLYARLR-RLI--RNIPQF---ELMKIE-E--------ALA-EGL-----ELE-GF----HSHVLE-VFRQAVEFLRSALKDKEVLNKIAEN-PFL---SLK-KE-------GEK--WYI-EIPDVRTYIQASGRTSRLFAGGITKGLSVIIV--DD--QKVFNGLVRQMR--WRFVE-FEI------K-----------------RF------------DE------I-------NLEEILKEIDRDREKVRLV-IE-G
>WP_010868381.1 reverse gyrase [Pyrococcus abyssi]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCGGAITD-ERLAEKNPCEGC-L-----SE-PIKA----------------EDYEKLVFA----VRNALKLRGTL-------K----DWE-DLY--RLNKEVSEVEDLFKRAT-GFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFISIYF-AI-K--------G-K----RSYIVVPTTPLVVQT---VKKIQ-DM----MER-------A-GV---NVR-------------LVYYH-GNL--KKKEKE-EALKRIKD-GDF-D------ILVTSSQFLATRFDELL-RD--K-----RFDLIFVDDVDAFLKA-SKNIDRSLLLLGFTQ--EVINRA-------WEVIKLKK---QLA---KLLQAQ-GK--E-------KE-VEE----LNKE-------I-----------EKIEREIERYRR--EN--N-IG-IL--IVASAT--GSARGD-RIKLYRELLGFEVGSGRS-VLRNIVDTYI----IPER-----------------SI-EEEVE------------NLLRKLG-K---GGLIFVPIDKGIEF-------AEELTNYLKSK-GFKVELVSAK---N---KRGLELFERGEVDYLVGVATYYGTIVRGLDLPHLIRFAVFAGVPKFRFSM-------DL-EQ-PTIYRVLGLMSEILEF-L-PQE------KREEG-EKLYARLR-RLI--RNIPQY---ELMKIE-E--------ALA-EGI-----ELE-GF----HNHVLD-VFKQAVEFLREVLRDEEVIRRISEN-PFL---SLK-EV-------EGK--LYI-EIPDVRTYIQASGRTSRLFAGGITKGLSVIIV--DD--QKVFNGLIRQMR--WRFVE-FEI------K-----------------KF------------EE------I-------NLESVLREIDEDRKKVRLV-IE-G
>RLE60657.1 reverse gyrase [Thermoprotei archaeon]
-----------------------------MDIFPYKVVN-----------------------------------VR----------------------------------------------------------------------------------------AFLQGMCPNCEGRITD-ERLVNRLPCRKC-LRD----S-QIGE-LCYRDKS-------VEDYYQWLIQ----VEKLLKRNDTL-------K----AYK-NIV--ELEREVEMYNRFFKKIV-GNNLWSAQRAWAKRVLQNKSFTILAPTGVGKTVFGSTIALYL-AT-K--------N-K----KSYIILPTTLLARQV---YERIL-NF----SSN-------V-DV---NVR-------------IVAYF-SGM--NSKEKK-ETLEKIAS-GNF-D------ILITTSHFLTRRFDI-L-ED--K-----KFDFIFVDDVDSILKS-SKSIDKLLYLLGYPS--EVINLA-------MENITLKI---KTS---YFLRTK--------KKI-----PED----LHKN-------I-----------EENSRKLNKFLS--SL--K-PG-CI--VISTAT--GKPRGL-RIRLFRELMGFDIGARAE-ILRNVIDTYK----FTEENK----------------L-VNEGV------------ELVRKLG-K---GGLIFVPPGTKDDF-------IETIVEMLNKY-GIKASYVHSK---D---KKGLEDFIDGKVDVLVGIATYYGLLVRGLDLPHLIKYTIFLGIPHFKFTA-------EV-EE-LSPTRLVQIALNIREL-L-SNK------EQARL-DRLVSSIR-QYL--TLLDQS---KFLLLM-Q--------AMK-ENK-----KLT-GP----LGKIQS-NIIQVRELLKRYFSDESIIRKIEEK-TIF---SIR-KI-------GEK--TYF-LLPDAMTYLQASGRTSRMYAGGISKGLSIVLT--SD--KKLFEGLVKQTR--WYSEE-ITW------V-----------------EL------------SE------L-------NLEEILVKITKEREFIRRI-IE-G
>KUJ99632.1 Reverse gyrase [Thermococcales archaeon 44_46]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCEDRISD-SRLYKKHPCEVC-L-----DE-EIKA----------------EVYFDLIKG----IRDALKLKGTL-------K----HWE-ELY--SLEKKLNEAEELFKKAT-GFTFWSAQKTWVKRLVRGKSFSIIAPTGMGKSVFGAFMSVYY-AK-K--------N-K----KSYIVLPTTPLVIQT---IKRVQ-TF----AEK-------T-GV---SVN-------------LAYYH-GNM--KKKEKE-EMLQKIQS-GEF-D------VLITSAQYLARNFD-IL-KD--K-----KFDFIFVDDVDAFLKA-SKNIDRSLILLGFTE--EIIQKA-------WEIIKLKK---QMA---KYLNGN-SKDKN-------EK-LKE----LNKQ-------I-----------NAIEKEIRKFKR--EN--K-IG-VL--IVASAT--GSARGD-RIKLYRELLDFEVGSGRS-ALRNVVDSYL----FPEK-----------------PI-EEHVK------------ELLETLG-P---GGLIFVPVDQGIAY-------AEKLTKYLQDL-GFKVELVSAK---N---KKGLEKFEKGEVDYLIGVATYYGSIVRGLDLPHLIRYAIFTGVPKFRFSI-------DL-EQ-PTIYRVLGLMSEVMEF-L-EDE------DRREA-EKLYARLR-RLI--RNIPQF---EILKIE-E--------ALA-EGL-----PLE-GF----SNHVLG-VFREAVEFLRNVLRKPEVLKRIEED-PFV---SLK-KE-------EGK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKILNGLKRQMR--WRFAE-FDM------K-----------------PF------------NE------L-------NLEEILKEIDADREKVRLI-ME-G
>WP_088866544.1 reverse gyrase [Thermococcus radiotolerans]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCLGKISD-ERLYLKNPCNEC-L-----DE-TAHA----------------DSYFDLVTA----VRNALQLRGTL-------K----EWE-RIY--GLEKGLREIEAFFEKAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWH-AT-R--------G-K----KSYIVVPTTPLVIQT---AKKLR-AI----AER-------A-GV---EIN-------------LAYYH-GNL--RKKERE-EMLAKIQN-EDY-D------ILVTSAQWLARKFDDVL-KG--R-----RFDFIFVDDVDAFLKA-SKNIDRSLLLLGFND--DVIEKA-------WEIIRLKK---QMS---KYLNGR-AQDRE-------ER-LKE----LNGS-------I-----------GKLQREIEEFKA--KN--G-VG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVVDSYL----KPSR-----------------DI-KEHVE------------ELLERLG-K---GGIIFTPIDQGLTY-------AEELANYLRER-GFRIELVSSK---N---RKSIEKFENGEADYLIGSATYYGSLVRGLDMPHLIRYAVFTGVPKFRFSI-------DL-ER-PTIYRALGLLSEIMEF-L-SDE------DRKQA-EKMHARLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PIENGF----HNHVLG-VFRELVEFLRRVLKDEEVLRRLAED-PFI---SLK-EE-------EGK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKVFNGLLRQMR--WRFTE-FKM------V-----------------PF------------EE------L-------DLDEVLRQIDEDREKVRLV-ME-G
>WP_088882843.1 reverse gyrase [Thermococcus sp. P6]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCLDRISD-ERLYMKNPCKEC-L-----DE-PLHA----------------DSYFDLVSA----VRNALKLRGTL-------K----EWE-RIY--SLEKDLREIEEFFRRAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWY-AS-R--------G-K----KSYIVVPTTPLVLQT---VKKLR-TI----IDN-------S-GL---EVR-------------VAYYH-GNL--RKKERE-EMLALIQK-GDY-D------VLVTSSQWLARKFDEVL-AG--R-----RFDFIFVDDVDAFLKA-SRNIDRSLFLLGFNE--EIIGKA-------WEIVRLKK---EMS---RYLNGR-ASDRE-------EK-LRE----LNDR-------I-----------SKLQLEIEEFRN--KN--N-VG-AM--VIASAT--GSARGD-RIKLYRELLGFEVGSGRS-SLRNVVDTYL----KPEK-----------------DI-KEHVE------------ELLQRLG-R---GGLVFTPIDQGLGY-------AEELAEYLRGK-GFKIEVVSSK---N---KNAIERFEKGEADYLIGSAAYYGSLVRGLDLPHLIRYAVFTGVPKFRFSV-------DL-ER-PTIYRTLGLLNEVMDF-L-SDE------DRKEA-ERLHARLR-RLI--RNIPSF---QILKIE-E--------ALA-EGL-----PLEDGF----HNHVLG-VFRKTVEFLRRVLKDEEVLRKLAED-PFV---SLK-EE-------GGK--WYI-EIPDVRTYIQATGRTSRLFAGGISQGLSVLIV--DN--EKVFNGLLRQMR--WRFTE-FRM------V-----------------PF------------EE------L-------DLDEVLRRIDEDREKIRLL-ME-G
>WP_042697994.1 reverse gyrase [Thermococcus sp. PK]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCEDRISD-SRLYKKHPCEVC-L-----DE-EIKA----------------EVYFDLIKG----IRDALKLKGTL-------K----HWE-ELY--SLERKLKEAEELFEKAT-GFTFWSAQKTWVKRLVRGKSFSIIAPTGMGKSVFGAFMSIYY-AK-K--------G-K----KSYIILPTTPLVIQT---IKRVQ-TF----AEK-------T-GV---SVN-------------LAYYH-GNM--KKKEKE-EMLQKIQS-GEF-D------VLITSAQYLARNFD-IL-KD--K-----KFDFIFVDDVDAFLKA-SKNIDRSLILLGFTE--EIIQKA-------WEIIKLKK---QMA---KYLNGN-SSDKN-------EK-LKE----LNKQ-------I-----------NAIEKEIRKFKR--EN--K-IG-VL--IVASAT--GSARGD-RIKLYRELLDFEVGSGRS-ALRNVVDSYL----FPEK-----------------PI-EEHVK------------ELLKALG-S---GGLIFVPVDQGIAY-------AEKLTKYLQDL-GFKVELVSAK---N---KKGLEKFEKGEVDYLIGVATYYGSIVRGLDLPHLIRYAIFTGVPKFRFSI-------DL-EQ-PTIYRVLGLMSEVMEF-L-EDE------DRREA-EKLYARLR-RLI--RNIPQF---EILKIE-E--------ALA-EGL-----PLE-GF----SNHVLG-VFREAVEFLRNVLRKPEVLKRIEED-PFV---SLK-KE-------EGK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKILNGLKRQMR--WRFAE-FDM------K-----------------PF------------NE------L-------NLEEILKEIDADREKVRLI-ME-G
>RLG75806.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------MISE--PH----------------------------------------------------------------------------------------GIYRHGCINCSGEISD-LRLSYMLPCEKC-LPI-R-VE-DLIK----------------AMPSPTHTD----IIKLTEKLGTL-------K----KLR-KLK--YIISEVNEFHRLFEKLI-GNKMWSAQETWAKRVLKKESFSIVAPTGVGKTVFGIVASIYF-AR-K--------N-L----KSYIIVPTTPLVLQV---HGKLV-EF----VKK-------L-NK---PIN-------------VIAYH-AKL--GSKEKK-KTLEDIAN-GNF-H------ILVTTSKFLSARFDI-L-KD--N-----RFYFIFVDDVDAILKS-SKNIDYVLMLLGFTE--EEIQTA-------YEFIKLKR---KLA--QPSLSEK-------ER---SML-LKN----IM-K-------K-----------QKLIERFSR--R------V-KG-VL--IVSSAT--GRPRGL-RVKLFRELLGFEVGTRSE-YLRAIIDTYL----KPEN-----------------SI-EEEVA------------KLVNLLG-K---GGLIFVPIDKGVEY-------AKTLVEFLQKK-GIKAKMFISK---E---IKALEEFINGEVDVLVGVATYYGVMVRGLDLPEIIRYAIFAGIPRFKFST-------KL-DE-PHPLNIMRALVILREI-LEKDE------KKEKI-DKLIVKMK-KYL--TIAPAA---ALSEIA-K--------KLK-ENI-----PPE--------TVAEK-IFYEALSLARLLLEKTEIKRKLKEL-KEV---AIV-EE-------NGR--MYI-LIPDIMTYIQASGRTSRMFVGGITKGLSIVIV--DD--ERLLYGLLRRTK--WFIED-MAW------I-----------------DL------------KT------V-------DLKAVMKEIDEDRELVRAV-RE-G
>WP_014733806.1 reverse gyrase [Pyrococcus sp. ST04]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCNGAITD-ERLASKNPCDAC-L-----DK-PEIS----------------ENYFDLVTA----VRNALKLRGTL-------K----HWE-ELY--KLNKEVKEVEDLFKKAT-GFTFWSAQRTWVKRIIKGKSFSIIAPTGMGKSTFGAFISIYF-AI-K--------G-K----KSYIVVPTTPLVIQT---VKKIQ-GM----LEK-------A-NV---NVK-------------LLYYH-GNM--KKKEKE-EALEKIRS-GDF-D------ILVTSSQFLATRFEELL-RD--K-----HFDLIFVDDVDAFLKA-SKNIDRSLLMLGFNE--DIIGKA-------WEIIKLKK---QLA---KLLSNE-NA--S-------EE-VEK----LNKE-------I-----------EKLEKEIEKYKK--DH--D-IG-IL--IVASAT--GSAKGD-RIKLYRELLGFEVGSGRS-VLRNIVDTYI----VPQK-----------------SV-EEHIE------------ELLKKLG-K---GGLIFVPIDKGIEY-------AEKLTEYLKNK-GFRIELVSAK---N---KKGLELFEKEEVDYLVGVATYYGTIVRGLDLPHLIRFAIFAGVPKFRFSL-------DL-EQ-PTIYRVLGLMSEILEF-L-PED------KRSEG-EKLYARLR-RLI--RNIPQY---DLMKIE-E--------ALA-EGL-----ELE-GF----YSHVLE-VFKQAVGFLREALKDEEVLRKIAEN-PFL---SLK-KE-------GEK--WYI-EIPDVRTYIQASGRTSRLFAGGITKGLSVIIV--DD--QKVFNGLVRQMR--WRFVE-FEI------K-----------------SF------------EE------I-------NLEEVLREIDKDREKVRLV-IE-G
>OYT50813.1 reverse gyrase [Candidatus Bathyarchaeota archaeon ex4484_135]
--------------------------------------------------------------------------MR----------------------------------------------------------------------------------------AVFERSCPNCGGRISD-IRLLMGIPCDKC-LPL-P-DE-ELSE-KLKG-----------LSKEEAMIF----CLEKLKELGTL-------K----HYA-SLV--EFHRKVADFEAFFEKAL-GCPPWSAQRTWARRVLSGKSFAIVAPTGSGKTAFGSILALYM-AS-K--------G-L----KSYILVPTSLLVKQV---YEKAI-SM----ADR-------V-GL---EAK-------------IVCYH-SML--TKKEAE-EALKAIKE-GDF-D------VLITTSFFLARRREL-L-EG--R-----KFDLIFVDDVDAFLRS-SKNVDVVLEMLGVPP--EAIEKA-------LEVLKLRT---EIS---KLLREK--------KA--SKE-LDE----LREK-------L-----------LELEAEIEAVRE--AP--G-KG-VL--IVSGAT--IRAKRTKRIKLFRELLSFEVGGRSE-GLRNVENVFA----IPE-GP----------------L-EETVL------------DLVKRLG-P---GGLVFVPLDKGSAY-------AEELAEFLKEK-GIRAEAFTRA---R---KKVVDAYVSGDLDVLVGVASFRSPLARGIDLPARIRYAVFAGVPKMRISL-------AI-SE-FRPHRAVILLANLRDV-L-SGE------EADRA-DAYIARLR-RIS--VLLRRD---ELKEIV-Q--------ALA-EGR-----RLS-GF----LEHARS-FFEEVWRFLKDLLARPDVREAIRAS-PHL---SLD-EE-------AGE--PYL-IVPDPVGYLQASGRTSRLYAGGISKGLSVLVV--DD--QKAFNGLRRALR--WYLEE-IEW------H-----------------SI------------EE------V-------DLKAIMAEVDRDRELIRKL-MA-G
>WP_013413183.1 reverse gyrase [Methanothermus fervidus]
-------------------------------------------------------------------------MYR----------------------------------------------------------------------------------------AIYKGMCPNCGKEIDD-SRLNAKNPCKSC-V-----EK-KLQC----------------EDYHELLEK----IEEYLKENNNL-------Y----GWK-EIY--ELHRDLKDIENLFEKAT-NSKFWNIQKTWFIRLIKGESFPIIAPTGVGKSIFGIFASLYY-AL-K--------N-K----KSYIIVPTTSLVLQT---VEKIK-KF----MEK-------T-QI---KVN-------------LAFYH-GKL----KEKE-KMKNKIEN-DDF-D------ILVTTSQYLAINFD-IL-KN--K-----KFDFIFIDDVDAFLKS-SRNIDRSLILLGFSE--EIIEKG-------WELIKLKE---R---------GP-----------------KR----NSEQ-------I-----------KKIENKIKEFKE--KN--K-IG-NL--VVASAT--IKVKNK-RIKIYRELLNFEITGEVP-TIRNMVDSYI----KTDE-----------------KI-EKHLV------------KLLNILG-N---GGIIFVPTDQGIEK-------AKKIENYLKNN-GFKVKLVSSA---D---KTGIKEFKEGKIDYLVGVATYYGVLVRGLDIPERVRYTIFTGVPKHRFVI-------NL-DS-PRLYSIIILLRVLIDV-L-KGN------YKRKA-ESLYTKLQ-K------IPKY---KIKEIE-K--------KLE-NG----------HA----DSRITK-IYDDSVKFVRKIFKKEEIRKKIFSN-EFL---SME-IQ-------NNK--LCI-KFPDLRTYIQASGRASRLFAGGITHGLSVVII--DD--EKVFEGLKRQYK--WQFQK-HEF------K-----------------AF------------EK------L-------KLKKILNKIDEDRKKVKAI-KKHG
>WP_068321043.1 reverse gyrase [Pyrococcus kukulkanii]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCRGAITD-DRLASKNPCDAC-L-----DE-PEVH----------------EDYFKLITA----VRNALKLRGTL-------K----EWE-EVY--RLNKEVKDVEEFFKKAT-GFTFWSAQRTWVKRIIKGKSFSIIAPTGMGKSTFGAFISIYF-AS-K--------G-K----KSYIVVPTTPLVVQT---VKKIK-GM----IER-------A-GV---SVK-------------LVYYH-GNL--KKKEKE-EALEKIRS-GDF-D------ILVTSSQFLATRFDELL-KD--K-----HFDLIFVDDVDAFLKA-SKNIDRSLLMLGFNE--EMIGKA-------WEIIKLKK---QLA---KLLSKE-NS--N-------EE-IEK----LNRE-------I-----------ERLEREIERYKR--EN--E-IG-IL--IVASAT--GSAKGD-RIKLYRELLGFEVGSGRS-VLRNIVDTYI----VPEK-----------------SM-EEHVA------------ELLEKLG-K---GGLIFVPIDKGIEY-------AEHLANYLRER-GFKVELVSAK---N---KKGLELFEQEEVDYLVGVATYYGTIVRGLDLPHLIRFAIFTGVPKFRFSL-------DL-EQ-PTIYRVLGLMSEILEF-L-PEE------KRSEG-EKLYARLR-RLI--RNIPQF---ELMKIE-E--------ALA-EGL-----ELE-GF----HSHVLE-VFKQAVEFLRSALKDEEVLRKIAEN-PFL---SLK-KE-------EEK--WYI-EIPDVRTYIQASGRTSRLFAGGITKGLSIILV--DD--QKVFNGLVRQMR--WRFVE-FDI------K-----------------RF------------DE------I-------NLEEILKEIDRDREKVRLV-IE-G
>WP_004068124.1 reverse gyrase [Thermococcus litoralis]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCEDRIGD-LRLYKKHPCEVC-L-----DE-EIKA----------------EVYFDLIKG----IRDALKLRGTL-------K----HWE-ELY--SLEKKLNEAEELFKKAT-GFTFWSAQKTWVKRLVRGKSFSIIAPTGMGKSVFGAFMSIYY-AK-K--------G-K----KSYIILPTTPLVIQT---IKRVQ-TF----AEK-------A-GV---SVN-------------LAYYH-GNM--KKKEKE-EMLQKIQN-GDF-D------ILITSAQYLARNFD-LL-KD--K-----RFDFIFVDDVDAFLKA-SKNIDRSLILLGFTE--EIIQKA-------WEIIKLKK---QMA---KYLNGN-SKDKN-------EK-LKE----LNKQ-------I-----------NAVEREIRKFKR--EN--K-IG-VL--IVASAT--GSGRGD-RIKLYRELLDFEVGSGRS-ALRNVVDSYI----FPEK-----------------PI-EEHVK------------ELLKALG-S---GGLIFVPIDQGIVY-------AEKLTNYLQDL-GFKVELVSAR---N---KKGLERFEKGEVDYLIGVATYYGSIVRGLDLPHLIRYAIFTGVPKFRFSI-------DL-EQ-PTIYRVLGLMSEVMEF-L-ENE------DRRNA-EKLYARLR-RLI--RNIPQF---EILKIE-E--------ALA-EGL-----PLE-GF----SNHVLE-VFKEAVEFLRSVLKKPEVLKRIEED-PFV---SLK-KE-------EGK--WYI-EIPDVRTYIQATGRTSRLFAGGITRGLSVVIV--DN--EKVFNGLKRQMR--WRFAE-FDM------K-----------------PF------------NE------L-------NLEELLKEIDADREKVRLI-ME-G
>WP_088864286.1 reverse gyrase [Thermococcus barossii]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCLGKISD-ERLYLKNPCDEC-L-----DE-TVWT----------------DSYFDLVTA----VRNALQLRGTL-------K----EWE-RIY--GLEKGVREIEEFFERAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWH-AT-R--------G-K----RSYIVVPTTPLVIQT---VKKLR-AI----AER-------A-GV---EIN-------------LAYYH-GNL--RKKERE-EMLAKIQN-EDY-Q------ILVTSAQWLARKFDEVL-RG--R-----HFDFIFVDDVDAFLKA-SKNIDRSLLLLGFND--EVIEKA-------WEIIRLKK---QMS---KYLNGR-APDRE-------ER-LKE----LNSQ-------I-----------SELQREIEEFKR--KN--P-VG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVVDSYL----MPTK-----------------DI-REHVE------------ELLTRLG-K---GGIIFTPIDQGLGY-------AEELAKYLRER-GFRVELVSSK---N---RKSIERFENGEADYLIGSATYYGSLVRGLDMPHLIRYAIFTGVPKFRFSI-------DL-ER-PTIYRALGLLSEIMEF-L-SDE------DRKTA-EKLHARLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PIENGF----HNHVLG-VFRELVEFLRRVLKDEEVLKRLAED-PFI---SLK-EE-------EGK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKVFNGLLRQMR--WRFTE-FKM------V-----------------PF------------EE------L-------DLEEILRQIDEDREKVRLV-ME-G
>WP_014788222.1 reverse gyrase [Thermococcus cleftensis]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCAGRISD-ERLVMKNPCDEC-L-----ES-PVHA----------------DSYFELITA----VRNALQLRGTL-------K----EWE-RIH--SLEAGLREVEEFFEKAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAVMAVWH-AL-G--------G-K----KSYIVVPTTPLVIQT---AKKIQ-AI----AER-------A-GV---EIN-------------LAYYH-GNL--RKKEKE-EMLAKIEG-GNY-D------VLITSAQWLARNYDEKL-EG--R-----RFDFIFVDDVDAFLKA-SKNIDRSLYLLGFNE--EIIAKA-------WEIIRLKK---QMS---KYLNGR-SQDRE-------ER-LKE----LNSQ-------I-----------SELQREIEEFKR--EN--P-VG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVVDSYL----KPTK-----------------DI-REHVE------------ELLTRLG-K---GGIIFTPIDQGLSY-------AEELVGYLRER-GFRVELVSSK---N---RKAIERFENGEADYLIGSATYYGSLVRGLDLPHLIRYAVFTGVPKFRFSI-------DL-ER-PTIYRALGLLSEVMDF-L-SDE------DRKQA-EKLHARLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PIENDF----HNHVLG-VFRELVEFLRKVLRDEEVLKRLAED-PFV---SLV-EE-------EGK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKVFNGLVRQMR--WRFTE-FKM------V-----------------PF------------EE------L-------DLGELLRQIDEDREKVRLV-ME-G
>RLF20142.1 reverse gyrase [Thermoprotei archaeon]
---------------------------------------------------------------------MKLPTVR----------------------------------------------------------------------------------------AIFRRACPNCGGEITD-ERLWLMLPCERC-LPP-DEAE-KLVK-LYYSSK---------LTPLEFKLE----VFRKLKELGNL-------K----DYR-KVV--ELDILLKELDELFEKAI-GSKLWSAQRTWAKRVLEGRSFAIIAPTGVGKTMFGIVASLYL-AL-K--------G-K----RCYMVLPTSLLVKQV---YERMR-TI----AEK-------L-KI---DVN-------------IIAYL-SGL--SKSVRK-EYDEKVKQ-GDF-N------ILITTSQFLARNFDSLL-KG--L-----RFDFIFVDDVDALLKS-SRNIDRVLMLLGFTE--EHIQLG-------LELIRLKR---RVPYLLTLAKKS--------EEY-AKE-LEE----VRNK-------I-----------VVLKDKLKSIID--EV--K-PG-VL--IVSSAT--GRPRGL-RVRLFRELLNFEAGSRSE-LIRNIQDIY-----VPGAKD----------------L-LKATL------------DIIKLFG-T---GALVFVPLDKGVAF-------AEKVKEYLVSN-GIRADVVTAT--KK---KDQIERFIAGELDVLIGMATYYGLLVRGLDLPQRIRYAVFVGVPKFRFFL-------DI-TE-AQPFRIVSLLTDLRDY-V-EGK------EKEEV-DRIVGLMM-RYL--RELPPS---RIQEIS-E--------AIS-KRT-----KLS-GR----LGKVQE-LFEYGFRKVQELLKREDIRKKLIES-PYI---LVE-EV-------EDK--LRV-TVPDVMTYIQASGRTSRMFAGGISKGASIVIV--DN--PKVFEGLVRKTR--WFIED-ISW------K-----------------PI------------EE------V-------NVKKLIEEIDRDRDLIRKI-ME-G
>RLF87790.1 reverse gyrase [Thermococci archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCEDRIGD-LRLYKKHPCEVC-L-----DD-EIKA----------------EVYFDLIKG----IRDALKLKGTL-------K----HWE-ELY--SLEKKLNEAEELFKKAT-GFTFWSAQKTWVKRLVRGKSFSIIAPTGMGKSVFGAFMSIYY-AK-K--------G-K----KSYIILPTTPLVIQT---IKRVQ-TF----AEK-------A-GV---EVN-------------LTYYH-GNM--KKKEKE-EMLQKIQN-GDF-D------ILITSAQYLARNFD-LL-KD--K-----RFDFIFVDDVDAFLKA-SKNIDRSLILLGFTD--EIIQKA-------WEIIKLKK---QMA---KYLNGN-SKDKN-------EK-LKE----LNKQ-------I-----------NVIEKEIRKFKR--EN--K-IG-VL--IVASAT--GSARGD-RIKLYRELLDFEVGSGRS-ALRNVVDSYL----FPEK-----------------PI-EEHVK------------ELLKTLG-P---GGLIFVPIDQGIVY-------AEKLTNYLQDL-GFRVELVSAR---N---KKGLERFEKGDVDYLIGVATYYGSIVRGLDLPYQIRYAVFTGVPKFRFSI-------DL-EQ-PTIYRVLGLMSEVMEF-L-EDD------DRRNA-EKLYVRLR-RLI--RNIPQF---EILKVE-E--------ALA-EGL-----PLE-GF----SNHVLE-VFREAVEFLRSILRKPEVLRRIEED-PFV---SLK-KE-------EGK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVVIV--DN--EKVFNGLKRQMR--WRFAE-FDI------K-----------------PF------------NE------L-------NLEEILKKIDADREKVRLI-ME-G
>KUK17328.1 Reverse gyrase [Thermococcus sibiricus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYKGMCPNCEDKISD-ERLYKKHPCEIC-L-----ED-EIHS----------------DIYFDLITG----IREGLRVKNRI-------K----HWE-ELY--SLEKKLIEAEELFKNAA-GFTFWSAQKTWVKRLVKGKSFSIIAPTGMGKSVFGAFMSIYY-AK-Q--------G-K----KSYIILPTTPLVIQT---IKRVK-TF----AEN-------T-GI---DVN-------------LAYYH-GNM--KKKEKE-EMIQKIQT-GNF-D------ILITSGQYLARNFD-LI-KD--K-----KFDFIFVDDVDAFLKA-SKNIDRSLILLGFTE--EMIQKA-------WDIIKLKK---QMA---KYLNGN-RKDKN-------EQ-LKE----LNKQ-------I-----------SIIENEIREFKD--KN--K-IG-VL--IIASAT--GSARGD-RIKLYRELLDFEVGSGRS-ALRNVVDSYL----FPEN-----------------SV-EEHIK------------ELLKVLG-P---GGLIFVPIDQGITY-------AERLTNYLQDL-GFKVELISAR---N---KKGLQRFENGEVDYLIGVATYYGSIVRGLDIPHLIRYAIFTGIPKFRFSI-------DL-EQ-PTIYRVLGLMSEVMDF-L-ENE------DRKNA-EKLYARIR-RLI--RNIPQF---EILKIE-E--------ALA-EGL-----PLD-GF----SNHVLE-VFKEAVEFLRTVLKKEDVLRKIEED-PFV---SLK-KE-------ENK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVIIV--DN--EKVFNGLKRQMR--WRFAE-FEI------I-----------------PF------------HE------L-------ELEKVLQEIDADREKVKLL-ME-G
>WP_088853917.1 reverse gyrase [Thermococcus pacificus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCLGRISD-ERLVEKNPCDEC-L-----DN-PVHS----------------DSYFELVTS----VRNALQVKGTL-------K----EWE-RIY--SLEKNLREVEDFFEKAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWH-AT-R--------G-K----KSYIVVPTTPLVIQT---VRKIQ-AI----AGK-------A-GV---EVN-------------LAYYH-GNL--RKKEKE-EMLAKITG-GDY-D------ILVTSAQWMARKFDEVL-KD--R-----HFDFIFVDDVDAFLKA-SKNIDRSLYLLGFND--EVIGKA-------WEIIRLKK---QMS---KYLNGR-AQDRE-------EM-LKE----LNES-------I-----------AKLQREIEEFKS--NN--D-IG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVVDSYL----KPTK-----------------DI-KEHVE------------ELLTMLG-K---GGIIFTPIDQGLGY-------AEELVNYLRER-GFKVELVSSK---N---RKAIERFENGEADYLVGSATYYGSLVRGLDLPHLIRYAVFTGVPKFRFSI-------DL-ER-PTIYRALGLLSEVMDF-L-SDE------DRKQA-EKLHARLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PIENEF----HNHVLG-VFRELVEFLRRVLHDEEVLKKLAED-PFV---SLT-EE-------GGK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLLV--DN--EKVFNGLVRQMR--WRFTE-FKM------V-----------------PF------------EE------L-------DLDEVLKQIDEDREKVRLV-ME-G
>KUK28518.1 Reverse gyrase [Thermococcus sp. 40_45]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYKGMCPNCEDKISD-ERLYKKHPCEIC-L-----ED-EIHS----------------DIYFDLITG----IREGLRVKNRI-------K----HWE-ELY--SLEKKLIEAEELFKNAA-GFTFWSAQKTWVKRLVKGKSFSIIAPTGMGKSVFGAFMSIYY-AK-Q--------D-K----KSYIILPTTPLVIQT---IKRVK-TF----AEN-------T-GI---DVN-------------LAYYH-GNM--KKKEKE-EMIQKIQT-GNF-D------ILITSGQYLARNFD-LI-KD--K-----KFDFIFVDDVDAFLKA-SKNIDRSLILLGFTE--EMIQKA-------WDIIKLKK---QMA---KYLNGN-RKDKN-------EQ-LKE----LNKQ-------I-----------SIIENEIREFKD--KN--K-IG-VL--IIASAT--GSARGD-RIKLYRELLDFEVGSGRS-ALRNVVDSYL----FPEN-----------------SV-EEHIK------------ELLKVLG-P---GGLIFVPIDQGITY-------AERLTNYLQDL-GFKVELISAR---N---KKGLQRFENGEVDYLIGVATYYGSIVRGLDIPHLIRYAIFTGIPKFRFSI-------DL-EQ-PTIYRVLGLMSEVMDF-L-ENE------DRKNA-EKLYARIR-RLI--RNIPQF---EILKIE-E--------ALA-EGL-----PLD-GF----SNHVLE-VFKEAVEFLRTVLKKEDVLRKIEED-PFV---SLK-KE-------ENK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVIIV--DN--EKVFNGLKRQMR--WRFAE-FEI------I-----------------PF------------HE------L-------ELEKVLQEIDTDREKVKLL-ME-G
>WP_014012304.1 reverse gyrase [Thermococcus sp. 4557]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCLGRISD-ERLINKNPCSEC-L-----DD-TVTA----------------DSYFDLITA----VRSALKLRGTL-------K----EWE-RIY--SLENGLREVEGFFEKAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWH-AT-R--------G-K----KSYIVVPTTPLVVQT---ARKIR-KI----AEN-------A-GV---EVN-------------LAYYH-GNL--RKKEKE-EMLAKIQN-EDY-G------ILVTSAQWMARKFDEVL-KG--R-----HFDFIFVDDVDAFLKA-SKNIDRSLYLLGFND--EVIGKA-------WEIIRLKK---QMS---KYLNGR-AKDRE-------ER-LKE----LNAQ-------I-----------AELQRDIEEFKR--EN--P-IG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVADTYL----KPSK-----------------DI-KEHVE------------DLLTMLG-R---GGIIFTPIDQGLGY-------AEELADYLRER-GFRIELVSSK---N---RKAIERFENGEADYLIGSATYYGSLVRGLDMPHLIRYAIFTGVPKFRFSI-------DL-ER-PTIYRALGLLSEVMDF-L-SDE------DRKQA-EKLHARLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PIENEF----HNHVLG-VFRELVEFLRRVLKDEEVLRKLAED-PFI---SLK-EE-------DGK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKVFNGLLRQMR--WRFTE-FKM------V-----------------PF------------KE------L-------DLDEVLRQIDEDREKVRLV-ME-G
>RLE85948.1 reverse gyrase [Thermoprotei archaeon]
---------MLAWLPNFHALNKKLPDKCTCDSHKFNFVNHQV------------------------RLYREVRILK----------------------------------------------------------------------------------------AIFKNLCPNCKNEIDD-ERLQCKMPCAVC-LPV-S-VE-EYKK-LRNE-----------LKGYEFYKK----IAYELRKFKKL-------K----NYR-DIL--SLEKEVNEVNELFKKIL-GNEMWSAQRTWARRIIQKKSFSILAPTGVGKTAFAIIISLFL-AQ-K--------R-K----KIYIVLPTTLLVKQV---FEKTL-NF----MDK-------A-GI--DDIV-------------VLAYH-SGL--KLSEKK-SFYEKVKN-GNF-N------IVITTSQFLLRNFEY-L-SG--N-----HFDLIVVDDVDAVLKS-SKSVDKILLLLGFSQ--EIIDSA-------YHFIMLKK---RIA---TLLKSK--------KVI-----PKE----IQAE-------Y-----------RKLSKSISKFLS--KNKKN-LG-CL--IVSTAT--GRPRGL-RIKLFRELLGFEVGSRSE-FLRNIADLYL----NIKEED----------------L-PKHIV------------DLVKTLG-K---GGLIFVPVSKGLDY-------AKFIKDILAKN-GIKAAVVHAK---E---KEAIDEFAEGKVDVLIGVAIYYGLLVRGLDLPHVIRYAIFAGIPHFRFSL-------DV-EE-ALPSRLLQVSLNIREC-I-EPE------EKVHL-DRITSKLR-SIF--NELSYG---EILVLN-E--------AVK-TGK-----KLA-GK----LGYAQD-LSFQLQNILKKLLERENVRTCLASI-PMF---SLK-EI-------EGK--LYV-QIPDAMTYLQASGRTSRLFAGGLSRGVSIVLV--DD--ERLFNGLVKQTK--WYNDE-IEW------Q-----------------NL------------EE------M-------DIKKLIQKVDEDRNKIRLL-ME-G
>WP_055283293.1 reverse gyrase [Thermococcus sp. EP1]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AVYRGMCPNCQDVISD-ERLYNKHPCETC-L-----DE-EIKS----------------DVYFELVKG----IYDALKLKNTL-------K----HWE-EVY--SLEQRLIEAEKLFKTAT-GFTFWSAQKTWVKRLVRGKSFSIIAPTGMGKSVFGAFMSIYY-AK-K--------G-K----RSYIVLPTTPLVVQT---IKRVK-TF----AEK-------A-GI---DVN-------------LAYYH-GNM--RKKEKE-EMLQKIQT-GEF-D------VLITSAQYLARNFD-VL-KD--K-----RFDFIFVDDVDAFLKA-SKNIDRSLILLGFTE--EIIQKA-------WEIIRLKK---QMA---KYLNGN-RKDKN-------EQ-LKE----LNKQ-------I-----------NAIEKEIREFKR--KN--N-IG-VL--IVASAT--GSARGD-RIKLYRELLDFEVGSGRS-ALRNVVDTYL----SPQH-----------------PI-EEHVE------------EIIKKLG-T---GGLIFVPIDQGILY-------AEKLTSYLKDK-GFKVELVSAR---N---KKGLEKFENGEADYLIGVATYYGSIVRGLDLPHLIRYAVFTGVPKFRFSI-------DL-EQ-PTIYRVLGLMSEVMEF-L-ENE------DRKNA-EKLYARIR-RLI--RNIPQF---EILKIE-E--------ALA-EGL-----PLE-GF----SNHVLK-VFKEAVDFLRNILKKEDVLKRIEED-PFV---SLK-KE-------EGK--WYI-EIPDVRTYIQASGRTSRLFAGGITKGLSIVIV--DN--EKVFNGLKRQMR--WRFSE-FEM------V-----------------AF------------NE------L-------DLEKILQEIDRDREKVKLI-ME-G
>RLE92419.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AKFVNMCPNCGGTISD-ERLELKLPCKQC-LPE-V-PE-KIVQ-ML---KN-------EEPFFAGVSE----VRRLLKERDAL-------K----NYE-EFY--RLEKEVEDANKLFYKAT-GNKLWSAQKTWLRRVISNRSFAVLAPTGVGKTLFGTFTAVYL-AK-K--------E-KE--NKSIIILPTSLLVKQV---YERAK-QM----AENL-----GL-DP---ERT-------------IIAYL-GRL--TGKKRE-EVFNRIRD-GDF-N------VLIVTSQFLRRNFKI-I-WN--EG--ANKYSFVFVDDVDAILRS-SKNIDQVLMLLGLPR--DAVADA-------LKLIYLKR---RIA---GYYARR--------QQV-----PEE----LYSE-------L-----------NELKDKLEKILK--GK--L-KG-CL--VISTAT--GKPRGT-RVKLFRELLGFEIGARTE-ALRNVVDSYI----LPGSED----------------I-DDEVV------------KLIKTLG-K---GGLVFVPVSKGLEY-------AQALNEKLRQA-GIRSEVVHAK---K---KSALDRFVSGEVDVLVGVAVYYGLLVRGLDLPHIVKYAVFAGVPHFKFSL-------NL-EE-AGPFRLLQFAFNIRPA-L-EGY------EQSQL-DRLVGKIR-RVI--YDLDAA---SVQILT-E--------ALK-EGK-----ELE-GR----LEYVRK-NLVELKHLLIQELSKKDVVKRLEEK-TML---VIR-TE-------EGQ--QYI-YVPDTMTYLQASGRTSRLYAGGLSKGLSVVVV--DD--EGLFNKLVRQSR--WYSDE-IEW------V-----------------NF------------ND------L-------DVEKLMKEINKEREFIAKL-IR-G
>WP_048056247.1 reverse gyrase [Methanocaldococcus fervens]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------MIYKEMCPNCNGEITS-KRLEIGV-CEKC-LKE-EKAF--------------------------EKLK----LCEKLREEKTL-------K----NLK-NYC--NIWNEFKEFEEFVKDL--GFELLSIQKMWAKRVLKNKSFSIVAPTGVGKSFFGILMSLFL-SK-K--------G-K----KCYIILPTTLLVKQT---YEKMI-SL----IEK-------N-NL---NVK-------------VVAYH-SEL--STKEKK-EAKERIDN-NDY-D------ILITTSNFLAKNMP--------NN----VFDFIFVDDVDALLKA-SKNIDRTLKLLGFDD--EIINEA-------YKIIY-------LIK--------------------IGK-IES----ALKKR------------------EFLKKKISK--------IN-HG-CL--IIASAT--GKSYGD-RVKLYRELLDFEIGFGMN-KLRDVADIYD------------------------EEFSKEKIL------------EYVKLFG-S---GGIVFVSIDYGVEK-------AQEIEKFLLKN-NIKAKLIHSKD------KKGFDDFRNGEIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKFKIRL----------KE---------YINSLKEKGELKED------IDIEG-KT-------------------------------------------------------------------EEEIREIIVEKL-------KIKN----F---SLR-KE-------DGE--YLL-LIPDVKTYIQASGRTSRMTEFGLTKGASIVLV--DE--KEIFEALKKYML--FMY-E-SEF------R-----------------KI------------DE------I-------NLEELIKKIDEDRE---KI-KL-G
>RLE77969.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------------MH----------------------------------------------------------------------------------------AAFELMCPNCGGPNTD-DRLILGLPCPKC-LP--D-VE-SLLRARASV-----------TDPLEFKLL----VLEALKRQGTH-------R----MYEAEVV--ALERELRKVNEFFRRAL-GNEPWSAQRTWIKRVLEGKSFSILAPTGVGKTAFGMIMSLYL-AA-Q--------G-K----RCYIVLPTTILVKQV---SKRME-EY----RER-------L-RL--ETVR-------------VLAYH-GSM--SASEKR-EFQERLSS-GDF-D------VLVTTSQYLARNFDL-L-SG--I-----KFDFIFVDDVDALLKS-SRNIDRVLMLLGFTR--DVVDDA-------LQLVYLKR---RMA---AYVASR--------RRL-----PED----LLEE-------Y-----------NELVERISKRLR--EG--S-FG-TL--VVSTAT--GRVRGL-RSKVFRELLGFEVGSRPE-LLRNVYDTYV----VPEGEG-------------R--L-MEEVL------------RLVRELG-S---GGLVFVPVDYGVEY-------AKKLADFLSSH-GVKCKAVHAD---E---KEPVDEFARGDLDVLVGVAIYYGLLVRGLDLPERIRYAVFAGVPRFKFSM-------RV-DD-ASPIRLLSIASSIREY-L-PEP------EADEL-GRLIVRLR-RLL--ATSSQR---TLAELA-E--------VMR-GER-----ELT-GES-SYLAAILE-VVRDLRRSLQRLLSDKAVIESLMAS-KYL---SLR-EE-------NGE--LYL-YVPDTMTYLQASGRTSRMYAGGVSRGLSVVIV--DD--EKLLNGLMRQSK--WYSED-IEW------R-----------------RL------------DE------L-------DLKRVLEEIDRDRSVIRAL-RE-G
>ACV23891.1 reverse gyrase [Methanocaldococcus fervens AG86]
---------------------------------------------------------------------MLVLLMIP---------------------------------------------------------------------------------------MIYKEMCPNCNGEITS-KRLEIGV-CEKC-LKE-EKAF--------------------------EKLK----LCEKLREEKTL-------K----NLK-NYC--NIWNEFKEFEEFVKDL--GFELLSIQKMWAKRVLKNKSFSIVAPTGVGKSFFGILMSLFL-SK-K--------G-K----KCYIILPTTLLVKQT---YEKMI-SL----IEK-------N-NL---NVK-------------VVAYH-SEL--STKEKK-EAKERIDN-NDY-D------ILITTSNFLAKNMP--------NN----VFDFIFVDDVDALLKA-SKNIDRTLKLLGFDD--EIINEA-------YKIIY-------LIK--------------------IGK-IES----ALKKR------------------EFLKKKISK--------IN-HG-CL--IIASAT--GKSYGD-RVKLYRELLDFEIGFGMN-KLRDVADIYD------------------------EEFSKEKIL------------EYVKLFG-S---GGIVFVSIDYGVEK-------AQEIEKFLLKN-NIKAKLIHSKD------KKGFDDFRNGEIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKFKIRL----------KE---------YINSLKEKGELKED------IDIEG-KT-------------------------------------------------------------------EEEIREIIVEKL-------KIKN----F---SLR-KE-------DGE--YLL-LIPDVKTYIQASGRTSRMTEFGLTKGASIVLV--DE--KEIFEALKKYML--FMY-E-SEF------R-----------------KI------------DE------I-------NLEELIKKIDEDRE---KI-KL-G
>RLF82021.1 reverse gyrase [Thermococci archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYKGMCPNCGDKISD-ERLYKKHPCEIC-L-----ED-EIHS----------------DIYFDLITG----IREGLRVKNTI-------K----HWE-ELY--SLEKKLIEAEELFKNAT-GFTFWSAQKTWVKRLVRGKSFSIIAPTGMGKSVFGAFMSIYY-AK-H--------G-K----KSYIILPTTPLVIQT---VKRVK-TF----AEN-------T-GI---DVN-------------LAYYH-GNM--KKKEKE-EMIQKIQT-GDF-D------ILITSGQYLARNFD-LI-KD--K-----KFDFIFVDDVDAFLKA-SKNIDRSLILLGFTE--EMIQKA-------WEIIKLKK---QMA---KYLNGN-RKDKN-------EQ-LKE----LNKQ-------I-----------SIIENEIREFKD--KN--K-IG-VL--IIASAT--GSARGD-RIKLYRELLDFEVGSGRS-ALRNVVDSYL----FPEN-----------------SV-EEHIK------------ELLKVLG-P---GGLIFVPIDQGIAY-------AERLTNYLQDL-GFKVELVSAR---N---KKGLQRFENGEVDYLVGVATYYGSIVRGLDIPHLIRYAIFTGIPKFRFSI-------DL-EQ-PTIYRVLGLMSEVMDF-L-ENE------DRKNA-EKLHARIR-RLI--RNIPQF---EILKIE-E--------ALA-EGL-----PLE-GF----SNHVLE-VFKEAVEFLRTILKKEDVLKRIEED-PFV---SLK-KE-------ENK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVIIV--DN--EKVFNGLKRQMR--WRFAE-FEM------I-----------------PF------------HE------L-------ELEKVLQEIDANREKVKLL-ME-G
>OYT28034.1 reverse gyrase [Thermofilum sp. ex4484_82]
-----------MYL----------------DSHKFNFVNHQV------------------------RLYREVRILK----------------------------------------------------------------------------------------AIFKNLCPNCKNEIDD-ERLQCKMPCAVC-LPV-S-VE-EYKK-LRNE-----------LKGYEFYKK----IAYELRKLKKL-------K----NYR-DIL--FLEKEVNEVNELFKKIL-GNEMWSAQRTWARRIIQKKSFSILAPTGVGKTAFAIIISLFL-AL-K--------R-K----KIYIVLPTTLLVKQV---FEKTL-NF----MDK-------A-GI--DDIV-------------VLAYH-SGL--KLSEKK-SFYEKVKN-GNF-N------IVITTSQFLLRNFEY-L-SG--N-----HFDLIVVDDVDAVLKS-SKSVDKILLLLGFSQ--EIIDSA-------YHFIMLKK---RIA---TLLKSK--------KVI-----PKE----IQAE-------Y-----------RKLSKSISKFLS--KNKKN-LG-CL--IVSTAT--GRPRGL-RIKLFRELLGFEVGSRSE-FLRNIADLYL----NIKEED----------------L-PKHIV------------DLVKTLG-K---GGLIFVPVSKGLDY-------AKFIKDILAKN-GIKAAVVHAK---E---KEAIDEFAEGKVDVLIGVAIYYGLLVRGLDLPHVIRYAIFAGIPHFRFSL-------DV-EE-ALPSRLLQVSLNIREC-I-EPE------EKVHL-DRITSKLR-SIF--NELSYG---EILVLN-E--------AVK-TGK-----KLA-GK----LGYAQD-LSFQLQNILKKLLERENVRTCLASI-PMF---SLK-EI-------EGK--LYV-QIPDAMTYLQASGRTSRLFAGGLSRGVSIVLV--DD--ERLFNGLVKQTK--WYNDE-IEW------Q-----------------NL------------EE------M-------DIKKIIQKVDEDRNKIRLL-ME-G
>RLF86474.1 reverse gyrase [Thermococci archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYKGMCPNCEDKISD-ERLYKKHPCEIC-L-----ED-EIHS----------------DIYFDLITG----IREGLRVKNTI-------K----HWE-ELY--SLEKKLIEAEELFKNAT-GFTFWSAQKTWVKRLVRGKSFSIIAPTGMGKSVFGAFMSIYY-AK-H--------G-K----KSYIILPTTPLVIQT---VKRVK-TF----AEN-------T-GI---DVN-------------LAYYH-GNM--KKKEKE-EMIQKIQT-GDF-D------ILITSGQYLARNFD-LI-KD--K-----KFDFIFVDDVDAFLKA-SKNIDRSLILLGFTE--EMIQKA-------WEIIKLKK---QMA---KYLNGN-RKDKN-------EQ-LKE----LNKQ-------I-----------SIIENEIREFKD--KN--K-IG-VL--IIASAT--GSARGD-RIKLYRELLDFEVGSGRS-ALRNVVDSYL----FPEN-----------------SV-EEHIK------------ELLKVLG-P---GGLIFVPIDQGIAY-------AERLTNYLQDL-GFKVELVSAR---N---KKGLQRFENGEVDYLVGVATYYGSIVRGLDIPHLIRYAIFTGIPKFRFSI-------DL-EQ-PTIYRVLGLMSEVMDF-L-ENE------DRKNA-EKLHARIR-RLI--RNIPQF---EILKIE-E--------ALA-EGL-----PLE-GF----SNHVLE-VFKEAVEFLRTILKKEDVLKRIEED-PFV---SLK-KE-------ENK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVIIV--DN--EKVFNGLKRQMR--WRFAE-FEM------I-----------------PF------------HE------L-------ELEKVLQEIDANREKVKLL-ME-G
>WP_013467038.1 reverse gyrase [Thermococcus barophilus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCEDRISD-ERLYKKHPCDVC-L-----DR-EIQA----------------EIYFDLITG----IREALKLRRTL-------K----HWE-NIY--KLEKKLREIEDLFEKAT-GFNFWSAQKTWVKRLIKNKSFSIIAPTGMGKSVFGSFMALYY-AK-K--------K-K----KSYIVLPTTPLVVQT---IKRVK-TF----AER-------A-GI---EIN-------------LAYYH-GGM--KKKEKE-EMTEKIMS-GDF-D------ILITSAQWLARNFDEML-KD--K-----RFDFIFVDDVDAFLKA-SKNIDRSLILLGFTE--EIIQKA-------WEIIRLKK---QMA---KFLNGN-SPDKQ-------EQ-LKE----LNKQ-------I-----------NKLEREIRKFKR--EN--K-IG-VL--IVASAT--GSARGD-RIKLYRELLDFEVGSGRS-ALRNVVDSYL----FPEK-----------------SI-EEHVE------------ELLTKLG-K---GGLIFVPIDQGISY-------AEKLTQYLQEK-GFKVELVSAR---N---KKGLEKFENEEIDYLVGVATYYGTIVRGLDLPHLIRYAIFTGVPKFRFSL-------DL-EQ-PTIYRVLGLMSEVMEF-L-DEE------DRREG-ERLYARLR-RLI--RNIPQF---ELMKIE-E--------ALA-EGL-----PLE-GF----HSHVLE-VFKQSVEFLRRVLKKEEVLKRIEED-PFV---SLK-EE-------EGK--WYI-EIPDVRTYIQASGRTSRLFAGGITKGLSVIIV--DN--EKVFNGLKRQMR--WRFAE-FEM------K-----------------PF------------EE------L-------NLEELLREIDSDREKVRLI-LA-G
>WP_056933692.1 reverse gyrase [Thermococcus barophilus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCEDRISD-ERLYKKHPCDVC-L-----DR-EIQA----------------EIYFDLIMG----IREALKLRGTL-------K----HWE-NIY--KLEKKLREIEDLFEKAT-GFNFWSAQKTWVKRLIKNKSFSIIAPTGMGKSVFGSFMALYY-AK-K--------K-K----KSYIVLPTTPLVVQT---IKRVK-TF----AER-------A-GI---EIN-------------LAYYH-GGM--KKKEKE-EMTEKIMS-GDF-D------ILITSAQWLARNFDEML-KD--K-----RFDFIFVDDVDAFLKA-SKNIDRSLILLGFTE--EIIQKA-------WEIIRLKK---QMA---KFLNGN-SPDKQ-------EQ-LKE----LNKQ-------I-----------NKLEREIRRFKR--EN--K-IG-VL--IVASAT--GSARGD-RIKLYRELLDFEVGSGRS-ALRNVVDSYL----FPEK-----------------SI-EEHVE------------ELLTKLG-K---GGLIFVPIDQGISY-------AEKLTQYLQEK-GFKVELVSAR---N---KKGLEKFENEEIDYLVGVATYYGTIVRGLDLPHLIRYAIFTGVPKFRFSL-------DL-EQ-PTIYRVLGLMSEVMEF-L-DEE------DRREG-ERLYARLR-RLI--RNIPQF---ELMKIE-E--------ALA-EGL-----PLE-GF----HSHVLE-VFRQAVEFLRRVLKKEEVLKRIEED-PFV---SLK-EE-------EGK--WYI-EIPDVRTYIQASGRTSRLFAGGITKGLSVIIV--DN--EKVFNGLKRQMR--WRFAE-FEM------K-----------------PF------------EE------L-------NLEELLREIDSDREKVRLI-LA-G
>WP_048201405.1 reverse gyrase [Methanocaldococcus bathoardescens]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------MIYKEMCPNCSGEITS-ERLEIGV-CEKC-LKE-ENVF--------------------------EKLE----LCEKLREEKTL-------D----NLK-NYC--IIWNEFKEFEEFVKDL--RFELLSIQKMWAKRVLKNKSFSIVAPTGVGKSFFGILMSLFL-SK-K--------G-K----KCYIILPTTLLVKQT---YEKML-SL----IEK-------N-KL---DID-------------VVAYH-SEL--STKEKK-EAKEKIEN-NDY-D------ILITTSNFLAKNPP--------NN----TFDFIFVDDVDALLKA-SKNIDRTLKLLGFDE--DIINEA-------YKIIY-------LIK--------------------IGK-IED----ALKKR------------------EILKEKISK--------IK-HG-CL--IIASAT--GKSYGD-RVKLYRELLDFEIGFGMN-KLRDVVDIYD------------------------EEFSKQKVL------------EYIKLFG-S---GGIVFVSIDYGIEK-------AQEIEKFLLEN-NIKAKLIHSKD------KKGFDDFREGEIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKFKIKL----------KE---------YINNLKEKGELKED------IDIEG-KT-------------------------------------------------------------------EEEIKKIVAEKL-------KIKN----F---SLR-KE-------DDE--YLL-LIPDVKTYIQASGRTSRMTEFGLTKGASIVLV--DE--KEIFEYLKKYIL--FMY-E-SEF------K-----------------KI------------DE------I-------NLEELIKKIDEDRE---KI-KL-G
>RLF10985.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------ALFKQACPNCRGDISD-DRLLAGLPCHRC-LDE-EEAA-ELLK-KVEEGQ-------------DLKKL----VLEALEGKGRL-------K----HYA-EVA--KPQFKAEEFNNFFKKAL-GLPLWSAQRTWAKRVLTGRSFAIVAPTGVGKTVFGLAMAAYL-AS-K--------G-E----KCYVVSPTTLLIEQA---RRRME-EI----LEA-------S-GL--KQLK-------------VAYYS-TAL--HRAEKI-EEADRIKK-GDF-D------ILITTSSFLARNFEE-L-KR--R-----RFGFIFVDDVDAILKA-SKNIDRVLVLLGFKE--EDVEKA-------LELLKLRG---ELA---RALRRR--------EES-A---VEE----LRGR-------Y-----------EQLSKEVARRLK--RR--K-PG-LL--VVSTAT--GRARGI-RVKLFRELLGFEVGSRAE-AIRNIQDIYL----KPKE-N----------------L-DEEVA------------ELAKKLG-P---GGLVFIPLDRGVES-------ADRIAKMLAKK-GVKAEVVYAK--GK---KERIAAFAKGEVDVLIGMASYYGLLVRGLDLPERVRYAIFAGVPKMRFSL-------EV-KE-AYPSRVLQLLLDVKDA-L-TGD------EQVTA-LRLIGRVR-RLL--WRLTPA---SFRELK-E--------ALE-KGV-----EPP-SW----LKQAYS-TVKEAADFLFQALSRSEVREKLRKS-THL---SFT-EE-------EGR--VTV-TVPDVPTYIQASGRTSRMYAGGVSKGVSIVVV--DD--EKVFTGLARQTR--WLADE-VRW------V-----------------SL------------EE------V-------DLEGLMKEVDDDRERVRRL-LS-G
>WP_048165500.1 reverse gyrase [Palaeococcus pacificus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AVYREMCPNCEGRISD-ERLVIKHPCENC-L-----DE-KLKT----------------DTYFQLLMG----IREGLKLKGTL-------K----EWE-RLY--QVESELRNVEELFKKAT-GYNFWSAQKAWVRRLIKGKSFSIIAPTGMGKSVFGSFMAVYY-AS-K--------G-K----KSYIVLPTTPLVKQT---IKKVQ-AF----AKN-------A-GI---DVD-------------LAYYH-SEL--KKKEKE-SMKEKIEK-GEF-D------ILITSAQFLARKFE-ML-QS--K-----KFDFIFVDDVDAFLKA-SKNIDRSLYLLGFTE--EAINKA-------WELIRLRR---QIG---KLLGGRQSEEKQ-------EE-LKR----INEE-------I-----------AKREKEIGEFIK--KT--G-IG-SI--IIASAT--GRGRGD-RIKLYRELLGFEVGSGRS-VLRNVEDVYL----LPSK-----------------SV-EEHLE------------ELLPKLG-N---GGLIFVPIDQGIAF-------AEELTLKLKEK-GFNVELISAR---N---KKGLEKFEQGEVDILVGMASYYGSIVRGLDLPHIIRYAIFTGLPKFKFSM-------DL-EQ-PTIYRVLGLMSEIFEF-L-DDE------DRREG-EKIHARLR-RLI--QTVPQY---EILKIE-E--------ALA-EGL-----PLE-GY----PNHVLD-VFKQAVEFLRKVLKKEDVIRRIEED-PFI---SLK-KE-------GEK--LYI-EIPDVKTYLQASGRTSRLFAGGITKGLALTIV--DN--VKVFNGMKRQLR--WRFPE-FEW------K-----------------AL------------EQ------V-------NLDEILEKIDQDREKVKGV-IE-G
>WP_042680401.1 reverse gyrase [Thermococcus paralvinellae]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCEDRISD-ERLYKKHPCNVC-L-----DE-EIQA----------------EVYFDLITG----IREALKLKGAL-------K----HWE-EIY--KLEKKLREIEELFEKAT-GFNFWSAQKTWVKRLIKNKSFSIIAPTGMGKSVFGSFMALYY-AK-K--------K-K----KSYIVLPTTPLVVQT---IKRVK-TF----AER-------A-GV---EIN-------------LAYYH-GGM--KKKEKE-EMTEKIMN-GDF-D------ILITSAQWLARNFDEML-KD--K-----RFDFIFVDDVDAFLKA-SKNIDRSLILLGFTE--EIIQKA-------WEIIRLKK---QMA---KFLNGN-SPDKQ-------EQ-LNE----LNKQ-------I-----------NKLEREIRKFKR--EN--K-IG-VL--IVASAT--GSARGD-RIKLYRELLDFEVGSGRS-ALRNVVDSYL----FPEK-----------------PI-EEHVE------------ELLAKLG-K---GGLIFVPIDQGIGY-------AEKLTQYLQEK-GFKVELVSAR---N---KKGLEKFENGEIDYLVGVATYYGTIVRGLDLPHLIRYAIFTGVPKFRFSL-------DL-EQ-PTIYRVLGLMSEVMEF-L-NEE------DRREG-ERLYARLR-RLI--RNIPQF---ELMKIE-E--------ALA-EGL-----PLE-GF----HSHVLE-VFKQSVEFLRRVLKKEEVLKRIEED-PFV---SLK-EE-------EGK--WYI-EIPDVRTYIQASGRTSRLFAGGITKGLSIIIV--DN--EKVFNGLKRQMR--WRFAE-FEM------K-----------------PF------------EE------L-------NLEELLREIDADREKVKLI-LA-G
>RLG61061.1 reverse gyrase [Candidatus Geothermarchaeota archaeon]
-----------------------------------------------------------------------MVILK----------------------------------------------------------------------------------------VIFEGLCPNCNGSISD-ERLLLGAPCKQC-LPV-AGRTLKTYS---------------ALPYTSYQVK----IAGLLEKFGTL-------R----EYK-TIS--ELSRAVLEFEELFKKAV-GSKLWSAQREWAKRVLKGVSFAITAPTGLGKTIFGMVMSLYL-AS-K--------G-K----KAYIVLPSRLLVEQV---LNKME-EF----KEK-------T-GL--NHLV-------------IIGYY-AGI--EKRKKE-KFLESLNE-GSF-D------IIVTSSRFITVNFDK-I-SK--Y-----VFDFIFVDDVDSVLKS-SKDIDKILRLLGIKE--AELALA-------YKAIKLKR---KAI---TMVKIG--------------E-RQH----VLDE-------I-----------RRTRDEIETLMA--SR--K-IG-VL--VVSTAT--GKAKGE-RIKLFRELLKFTIGATTI-GFRNIQDIYL----ERTE-----------------DV-EAQVL------------KLVKKLG-G---GGLIFVGLDDGKSL-------ADKLAESLRKA-GIVVETCYGAS-VK---PSVIRSFSDGDIDILIGMASYYGVLVRGIDLPHRIRYAIFTSIPRFKFKL-------EIKRD-IHPFRLFVLLNELAEY-M-DKE------DRKLA-DKLAVELK-RTV--LKLEKR---KVDEVY-E--------QLK-KGI-----EGE-------LSYYVN-VCLKAIEFLSKVLRKKEVLKKLEKS-PYL---SIK-EI-------EGQ--KYV-LIPDVRTYIQGSGRTSRLYAGGVTKGISIVLC--DD--SKLLRGLIRQLS--WRFEE-TRW------L-----------------HE------------SE------V-------NWDELVSEVDEDRRTVKLI-ME-G
>RLE82433.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------MTE---RH----------------------------------------------------------------------------------------ALFKELCPNCGGEIDD-TRLLLMAPCEKC-LPV-S-NK-ELYS-KMSS-----------MDPLEYKKY----LLKELESGGLL-------K----NYR-QVV--ELDERISEINLMFRKVL-GSNMWSAQRTWAKRLIQGKSFAILAPTGVGKTVFGIMAALYI-AS-R--------G-G----RSYIILPTTLLVSQV---HKKLQ-KF----SEK-------L-GL---NVK-------------ILGYS-GTR--GSARK--DFGEALEK-GEF-N------ILITTSQFLARNYDK-I-KN--F-----NFDFIFVDDVDALLKS-SKNIDRVLVLLGFPE--DVVNAA-------LRLIYIKR---SMA---YYISRK--------LEI-----PSE----ILNE-------R-----------KELEDKIKAFLS--NN--N-TG-LL--IVSTAT--GKVRGI-RVKLFRELLGFEVGSRAE-FLRNIADMYY----EPREES----------------L-EDAVV------------KIVSKLG-K---GGLVFVPVDKGVEY-------AEYLTKILNER-GIAAGLIHAR---E---KEPLQEFLEGRLDVLVGIAIYYGLLVRGLDYPEIIRYAVFAGVPRFKFAL-------EI-SE-PNPIRVLQLLINIRDT-L-KGN------DLDLA-EKYIVFIR-RVL--TELDKA---KLLRLM-E--------ALK-EGE-----TLS-GS----LGRIQE-RIIEVANFLKNLLAREDVIKEIEKL-PNV---SVI-RE-------NGR--LYI-LVPDAMTYLQASGRTSRMYAGGISKGLSVVIV--DD--KKLINGLIRQTK--WYSED-VEW------Q-----------------PW------------NE------K-------VVEEVIEEVNRDREKIRKV-LR-G
>WP_010878524.1 reverse gyrase [Archaeoglobus fulgidus]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------VVYSNLCPVCGGDLES-KEIEKH----VC-FRK-K-------------------------------------------------------R--------SLCLFPEDFLLKEFVEFFRKCV-G-EPRAIQKMWAKRILRKESFAATAPTGVGKTSFGLAMSLFL-AL-K--------G-K----RCYVIFPTSLLVIQA---AETIR-KY----AEK-------A-GV---GT------E-----NLIGYYH-GRI--PKREKE-NFMQNLRN---F-K------IVITTTQFLSKHYRE-L-GH---------FDFIFVDDVDAILKA-SKNVDKLLHLLGFHY--D------------------------------------------------LK-TKS----WVGE------------------------------------AR--G-CL--MVSTAT--AK-KGK-KAELFRQLLNFDIGSSRI-TVRNVEDVAV----NDES--------------------ISTLS------------SILEKLG-T---GGIIYART---GEE-------AEEIYESLKNK--FRIGIVTAT--K----KGDYEKFVEGEIDHLIGTAHYYGTLVRGLDLPERIRFAVFVGCPSFRVTIE------DI-D-----SLSPQMVKLLAYL-YRNVDE-----------------IE-RLLP-------------AVE-R---------------------------------H----IDEVREILKKVMGKERPQA------KDV---VV------------RE--GEV-IFPDLRTYIQGSGRTSRLFAGGLTKGASFLLE--DD--SELLSAFIERAK--LY--D-IEF------K-----------------SI------------DE------V-------DFEKLSRELDESRDRY----RR--
>1GL9_B Chain B, REVERSE GYRASE [Archaeoglobus fulgidus DSM 4304]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------VVYSNLCPVCGGDLES-KEIEKH----VC-FRK-K-------------------------------------------------------R--------SLCLFPEDFLLKEFVEFFRKCV-G-EPRAIQKMWAKRILRKESFAATAPTGVGKTSFGLAMSLFL-AL-K--------G-K----RCYVIFPTSLLVIQA---AETIR-KY----AEK-------A-GV---GT------E-----NLIGYYH-GRI--PKREKE-NFMQNLRN---F-K------IVITTTQFLSKHYRE-L-GH---------FDFIFVDDVDAILKA-SKNVDKLLHLLGFHY--D------------------------------------------------LK-TKS----WVGE------------------------------------AR--G-CL--MVSTAT--AK-KGK-KAELFRQLLNFDIGSSRI-TVRNVEDVAV----NDES--------------------ISTLS------------SILEKLG-T---GGIIYART---GEE-------AEEIYESLKNK--FRIGIVTAT--K----KGDYEKFVEGEIDHLIGTAHYYGTLVRGLDLPERIRFAVFVGCPSFRVTIE------DI-D-----SLSPQMVKLLAYL-YRNVDE-----------------IE-RLLP-------------AVE-R---------------------------------H----IDEVREILKKVMGKERPQA------KDV---VV------------RE--GEV-IFPDLRTYIQGSGRTSRLFAGGLTKGASFLLE--DD--SELLSAFIERAK--LY--D-IEF------K-----------------SI------------DE------V-------DFEKLSRELDESRDRY----RR--
>WP_048095487.1 reverse gyrase [Archaeoglobus fulgidus]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------VVYSNLCPVCGGDLES-KEIEKH----VC-FRK-K-------------------------------------------------------R--------SLCLFPEDFLLKEFVEFFRKCV-G-EPRAIQKMWAKRILRKESFAATAPTGVGKTSFGLAMSLFL-AL-K--------G-K----RCYVIFPTSLLVIQA---AETIR-KY----AEK-------A-GV---GT------E-----NLIGYYH-GRI--PKREKE-NFMQNLGN---F-K------IVITTTQFLSKHYRE-L-GH---------FDFIFVDDVDAILKA-SKNVDKLLHLLGFHY--D------------------------------------------------LK-TKS----WVGE------------------------------------AR--G-CL--MVSTAT--AK-KGK-KAELFRQLLNFDIGSSRI-TVRNVEDVAV----NDES--------------------ISTLS------------SILEKLG-T---GGIIYART---GEE-------AEEIYESLKNK--FRIGIVTAT--K----KGDYEKFVEGEIDHLIGTAHYYGTLVRGLDLPERIRFAVFVGCPSFRVTIE------DI-D-----SLSPQMVKLLAYL-YRNVDE-----------------IE-RLLP-------------AVE-K---------------------------------H----IDEVREILKKVMGKERPQA------KDV---VV------------RE--GEV-IFPDLRTYIQGSGRTSRLFAGGLTKGASFLLE--DD--SELLSAFIERAK--LY--D-IEF------K-----------------SI------------DE------V-------DFEKLSRELDESRDRY----RR--
>RLE81496.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------MTE---RH----------------------------------------------------------------------------------------ALFKELCPNCGGEIDD-TRLLLMAPCEKC-LPV-S-NK-ELYS-KMSS-----------MDPLEYKKY----LLKELESGGLL-------K----NYR-QVV--ELDERISEINLMFRKVL-GSNMWSAQRTWAKRLIQGKSFAILAPTGVGKTVFGIMAALYI-AS-R--------G-G----RSYIILPTTLLVSQV---HKKLQ-KF----SEK-------L-GL---NVK-------------ILGYS-GTR--GSARK--DFGEALEK-GEF-N------ILITTSQFLARNYDK-I-KN--F-----NFDFIFVDDVDALLKS-SKNIDRVLVLLGFPE--DVVNAA-------LRLIYIKR---SMA---YYISRK--------LEI-----PSE----ILNE-------R-----------KELEDKIKAFLS--NN--N-TG-LL--IVSTAT--GKVRGI-RVKLFRELLGFEVGSRAE-FLRNIADMYY----EPREES----------------L-EDAVV------------KIVSKLG-K---GGLVFVPVDKGVEY-------AEYLTKILNER-GIAAGLIHAR---E---KEPLQEFLEGRLDVLVGIAIYYGLLVRGLDYPEIIRYAVFAGVPRFKFAL-------EI-SE-PNPIRVLQLLINIRDT-L-KGN------DLDLA-EKYIVFIR-RVL--TELDKA---KLLRLM-E--------ALK-EGE-----TLS-GS----LGRIQE-RIIEVANFLKNLLAREDVIKEIEKL-PNV---SVI-RE-------NGR--LYI-LVPDAMTYLQASGRTSRMYAGGISKGLSVVIV--DD--KKLINGLIRQTK--WYSED-VEW------Q-----------------PW------------NE------K-------VVEEVIEEVNRDREKIRKV-LR-G
>WP_013100094.1 reverse gyrase [Methanocaldococcus infernus]
-------------------------------------------------------------------------MPVP---------------------------------------------------------------------------------------MIFKEMCPNCGGEISS-ERLTIGV-CENC-LPE-DIRL--------------------------EKLE----LCKKIE----V-------K----NLK-NYC--KVWREFKEFEDFVKSL--GYKLLSIQKMWAKRVLKNKSFSIVAPTGVGKSFFGVLISLYL-AS-K--------G-K----RCYIILPTTLLVKQT---YERIT-KI----IEE-------K-NL---KIN-------------VVAYH-SEL--KNREKR-EAKEKIEN-NEF-D------ILITTSSYLTKNMP--------KA----KFDFIFVDDVDALLKS-SKNIDRTLMLLGFSE--EHINLA-------SKIVF-------LIR--------------------IGK-FED----AMKLR------------------EELKEKIKD--------VK-HG-CL--VIASAT--GKSYGD-RVKLYRELLNFEVGFGMN-KLRDVTDLYD------------------------DKLSVEEIV------------RYVKKLG-D---GGLIFVSMDYGVEK-------AKEIEERLLEE-GVKAKLIHSKD------KKGFEDFKEGKLEVLIGVASYYGVLVRGLDMPERVRYSLFYGIPKFKIKL----------RE---------YVRKLVEEGKLKEE------IEIEG-KS-------------------------------------------------------------------LEEIENIVREKL-------KIRN----F---SLR-EE-------DDI--Y-L-LLPDVKTYIQASGRTSRMTEFGLTKGLSIVLS--DD--KKLLEYLSKYMI--FMY-E-SEF------K-----------------HV------------SE------V-------NLEEIIKEIDEDRE---RL-RR-E
>RLE95207.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------MRKL--FH----------------------------------------------------------------------------------------TVYADLCPNCGGEIKD-ERLLYSLPCEAC-LPI-E-VS-DFEK----------------SSPSEIKEK----VYRMLKEIGNL-------K----KYK-EVV--EVDKKLEEVDKIFHEVT-GSHLWSIQRTWVKRVLLGKSFTALAPTGVGKTVFGVTMSAYL-AS-K--------N-K----KCLIIEPTVPLVKQV---YERLK-PF----AEK-------L-K-----LR-------------VIAFY-GTL--STAKKK-ELVSRIEE-GDF-D------ILIVTSKFISSRFDI-I-KH--H-----KFAFIFADDVDSIIKS-SKNVDRVLMLLGFSE--EAVQAA-------MNAVKLKI---RLA--RLY-VYR-------NREEIEKV-LKE----LE-E-------V-----------EKIIEKEKK--K------V-RG-VL--VVSTAT--GRPRGL-RVKLFRELLSFDIGSRSE-TLRNIQDIYV----FPEN-----------------SV-EKKVL------------EIVKKFG-K---GGLVYVPVDKGIEY-------AEKLAVYLSEN-GIKAAAAHAK---A---RGALEKFMKGELDVLVGVATYYGILVRGLDLPEIIRYAVFAGVPRFKFSS-------ML-EE-VSAIGILRLLAYLRDA-V-EEK------ERQEV-EALLARLR-RRL--QTSSIA---ALTQLQ-K--------ALS-GEK-----PVE--------TFLEK-EFMKALEYTKSLLSRPDVVERLKES-GEV---VFI-EE-------NGR--KYV-LIPDIMTYLQASGRTSRLFVGGLTKGASIVVV--DY--KPLLNGLIKRSR--WIAE--TTW------A-----------------SL------------DE------I-------DVDELIEEIDKDRLQVKLI-RE-G
>1GKU_B Chain B, REVERSE GYRASE [Archaeoglobus fulgidus DSM 4304]
--------------------------------------------------------------------------AAA---------------------------------------------------------------------------------------AAAAAAAAAAAAAAAA-AAAAAA----AA-AAA-A-------------------------------------------------------A--------SLCLFPEDFLLKEFVEFFRKCV-G-EPRAIQKMWAKRILRKESFAATAPTGVGKTSFGLAMSLFL-AL-K--------G-K----RCYVIFPTSLLVIQA---AETIR-KY----AEK-------A-GV---GT------E-----NLIGYYH-GRI--PKREKE-NFMQNLRN---F-K------IVITTTQFLSKHYRE-L-GH---------FDFIFVDDVDAILKA-SKNVDKLLHLLGFHY--D------------------------------------------------LK-TKS----WVGE------------------------------------AR--G-CL--MVSTAT--AK-KGK-KAELFRQLLNFDIGSSRI-TVRNVEDVAV----NDES--------------------ISTLS------------SILEKLG-T---GGIIYART---GEE-------AEEIYESLKNK--FRIGIVTAT--K----KGDYEKFVEGEIDHLIGTAHYYGTLVRGLDLPERIRFAVFVGCPSFRVTIE------DI-D-----SLSPQMVKLLAYL-YRNVDE-----------------IE-RLLP-------------AVE-R---------------------------------H----IDEVREILKKVMGKERPQA------KDV---VV------------RE--GEV-IFPDLRTYIQGSGRTSRLFAGGLTKGASFLLE--DD--SELLSAFIERAK--LY--D-IEF------K-----------------SI------------DE------V-------DFEKLSRELDESRDRY----RR--
>RLE63160.1 reverse gyrase [Thermoprotei archaeon]
-------------------------------------------------------------------MVNE---AY----------------------------------------------------------------------------------------TRFKDLCPNCGREIDS-SRLRLMAPCRKC-LPL-P-DE-QLEL-RLQS-----------MSQLEYKKY----ILGELQKRGSL-------K----NFY-QVV--ELEEKVEKLNNMFRKCL-GNDMWSAQRTWIKRIIREKSFAILAPTGVGKTVFGIMTALYM-AS-Q--------G-K----RSYIILPTTLLVKQV---KEKAE-KF----AEK-------L-GI---DAK-------------ILAYV-RLN--TKKKKE-EFNDKIQQ-GDF-G------ILITTSQYLSRNLPR-L-KH--L-----KFDFIFVDDVDALLKS-SKNIDRVLVLLGFRE--EDVATA-------LRLIRVRR---QIA---YFFSRK--------LDV-----PEE----LKRE-------Y-----------EKLVEKVSKALK--ER--K-PG-VL--VVSTAT--GRVRGQ-RVKLFRELLGFEVGSRAE-FLRNIADVYL----RPK-TT----------------L-EKAVI------------DVVQRLG-K---GGLIFVPVDKGVQY-------AKTLVEMLREN-GIKAELIHAR---E---KKALEDFIQGKLDVAVGVAIYYGLLVRGLDYPEVIRYAVFAGIPRFKFAL-------EL-TE-PNPSRLLQLLINIREV-L-EGE------ELRVA-EKYIVFLR-RIF--MELDKT---KLVILF-E--------ALK-EGR-----ELS-GT----LRRYQE-RVLVATGFLRELLSRRDIINKLKHL-PTI---SIK-EE-------DGR--LFI-YVPDVMTYLQASGRTSRMYAGGISKGLSVVII--DD--EKLFNGLVRQSK--WYSED-VEW------Q-----------------PW------------GE------K-------RIEKILVEVDRDREKIRKI-LE-G
>RLE78051.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------------MR----------------------------------------------------------------------------------------AIFKDLCPNCGNEIDD-ERLQLKIPCSSC-LPV-P-IG-ELYK-MRRK-----------LNEMSFLES----IADRLEEIGRL-------K----NYR-RLV--ELERKIEELNTFFKKIL-GNDMWSAQRTWARRIFQNKSFSILAPTGVGKTVFAIIISLYL-AS-K-------ER-K----KAYLVLPTTLLVRQV---YEKAV-NF----AER-------A-GI--KSLS-------------IVAYY-TGL--KPSEKK-SVLENIKN-GKF-D------ILITTSSFLLRRFEY-L-AG--T-----KFDLIVVDDVDAILKS-SKSIDKVLALLGFKQ--EIIECA-------AKLIVLKR---RIA---INLKLK--------KSI-----PED----LSKE-------F-----------NNLNEKISDYLA--KYRNK-IG-CL--VVSTAT--GRPRGL-RVKLFRELLGFEIGSRSE-FLRNISDLYV----LIDNDL----------------L-DK-LL------------EVINKLG-K---GGLVFVPVSKGVEY-------AYIIANYLNEH-GIRATVVHAK---E---KEAINDFIQGKIDVLVGMAIYYGLLVRGLDLPHIIRYAVFVGVPHFRFSL-------DV-EE-ALPSRLLQVSLNIRDC-V-DPE------EREKL-DKITSRLR-TIF--NDLSYG---EVILLN-E--------AIK-TGK-----PLS-GK----LKYTLN-LVLQLREMLKKLLSRESVRERLASM-PMI---SLK-EV-------EGK--LYI-YIPDAMTYLQASGRTSRLFAGGLSKGLSVVLV--DD--KKLFNGLMKQTK--WYSDE-VEW------R-----------------RF------------NE------V-------DIDSLVKEIDQDREQIRLI-MA-G
>WP_012980123.1 reverse gyrase [Methanocaldococcus sp. FS406-22]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------MIYKEMCPNCNGEITS-ERLAIGV-CEKC-LKE-KNVF--------------------------EKLK----LCEKLREEKTL-------K----ELK-SYC--IIWNEFKEFEEFAKSL--GYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSFFGILMSLFL-AK-K--------G-K----RCYIILPTTLLVKQT---YEKML-SL----VEK-------N-NL---NIK-------------VVAYH-SEL--STKEKK-EAKERIEN-NDY-D------VLITTSNFLTKNMP--------NC----RFDFVFVDDVDALLKA-SKNIDRTLKLLGFDE--EIINEA-------YKIIY-------LIK--------------------IGK-IED----AMKKR------------------EILKEKVAK--------IK-HG-CL--IIASAT--GKSYGD-RVKLYRELLDFEIGFGMN-KLRDVVDIYD------------------------EEFSKEKIL------------EYIKLFG-S---GGIVFVSIDYGVEK-------AQEIEKYLLDN-NIKAKLIHSKD------KKGFDDFREGKIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKFKIRL----------KE---------YINSLKEKGELKED------IDIEG-KT-------------------------------------------------------------------EEEIRQIITEKL-------KIKN----F---SLR-KE-------DDE--YLL-LIPDVKTYIQASGRTSRMTEFGLTKGASIVLV--DE--KEIFEALKKYML--FMY-E-SEF------K-----------------RI------------DE------I-------NLEELIKKIDEDRE---KI-KV-G
>RLE66264.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------------MR----------------------------------------------------------------------------------------AVFKGLCPNCGNEIDD-VRLQLKLPCSSC-LPT-S-IK-KVSK-LREK-----------MDELSFLER----IAKELQKRGKL-------K----NYR-KLV--ELEKKIEELNDFFKKIL-GNDMWSAQRTWARRIFQNKSFSILAPTGVGKTVFAIMVSIYL-AS-K-------ER-K----KAYIVLPTTLLVKQV---YEKTL-KF----AEK-------A-GI--KNLS-------------IIAYY-TGL--KPSQKK-SILENIRN-GDF-D------ILITTSNFLLRRFEY-L-SN--T-----KFDLIIVDDVDAILKS-SKSIDKVLILLGFSQ--EIINYA-------SKLVLLKR---RIA---INLRLR--------KGI-----SED----LSRE-------F-----------KEVSEKVSSYVS--ENKNK-IG-CL--VVSTAT--GRPRGL-RIKLFRELLGFEIGSRSE-FLRNISDLYV----LAKENM----------------L-DK-LL------------GLINKLG-K---GGLIFVPVSKGVEY-------ANFIANFLNEN-GVKAAVVYAK---E---KEAINDFIEGKVDVLIGIAIYYGLLVRGLDLPHIIRYAIFVGVPHFRFSL-------DV-EE-ALPSRLLQVSFNIRDC-I-DPE------EREKL-DRITNRLR-TIF--NDLSYG---EVILLN-E--------AIR-TGR-----VLS-GK----LKYAYN-LVLQLREMLKNLLGKESVQRRLASM-PMI---SLK-QV-------KEK--LYI-YIPDAMTYLQASGRTSRLFAGGLSKGLSIVLV--DD--EKLFNGLMRQTK--WYSDE-VEW------R-----------------RL------------DE------V-------NLEFLLNEIDRDRERIKLL-ME-G
>RLF01146.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------MGKL--FH----------------------------------------------------------------------------------------TVYANLCPNCGGEIKD-ERLLYSLPCEVC-LPI-S-ME-EVAS----------------KSSVKIKNT----VYKLLKKIGNL-------K----DYR-EIV--EVEEKLKEVDKIFNEVT-GSHLWSIQRTWVKRVLLGKSFTALAPTGVGKTVFGIIMSAYI-AS-K--------G-G----KCLIIEPTVPLVKQV---YERIQ-PF----AEK-------L-G-----IR-------------VIAFY-GAL--SPSKKK-EMASRIQE-GDF-D------VLIVTSKFVSSRFDL-I-KD--K-----VFSFIFADDVDSIIKS-SKNVDRVLMLLGFSE--ETVRSA-------MEVVRLKI---RLA--RLYATSR-------NREEIEDT-AKK----IA-E-------L-----------EQTIERERK--Q------V-KG-VL--VVSTAT--GRPRGL-RVKLFRELLSFDIGSRSE-TLRNIQDIYV----IPEN-----------------SL-EEKVL------------EIVRLFG-K---GGIIYVPVDKGIEY-------AEELANYLVEN-GVNAAAAHAK---A---KGALEKFAKGEVDVLVGVATYYGILVRGLDLPEVVRYAVFAGVPRFKFSS-------ML-EE-ISAIGVLRLLAYLRDA-V-EEE------EKRKV-EALLARLR-RRL--QTSSVA---AIMQLQ-K--------VLS-GEK-----PAE--------TYLER-EFVKALEYTKSLLTRPDVVKRLKES-GEV---VFI-EE-------SGR--RYV-LIPDIMTYLQASGRTSRLFVRGLTKGASIVVV--DY--KPLLNGLIRRSK--WVAE--TTW------T-----------------PL------------DE------I-------DVKKLIEEIDRDRLQVRLI-RE-G
>WP_012965299.1 reverse gyrase [Ferroglobus placidus]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------VKYANLCSVCHKDVTW-EELEKS----YC-RFK-K-------------------------------------------------------L--------PQCSSFLDKIYKEFEEFFKKII-G-EPRSIQKFWAKRVLSFESFAAVAPTGIGKTSFGSAMALFL-AL-K--------K-R----KSYIILPTTLLVAQV---VENLK-KY----CEK-------A-GI---DCGLNEEKE-----VTIAYYH-GKL--K--EKD-KFFEILEK-NSF-D------ILVTTTQFLPRYFEK-L-NG--K-----IFNFIFVDDVDAVLKA-SRNVDRILKLLGFRY----------------------------------------------------K-NGK----WEGK------------------------------------PK--G-VL--MVSTAT--AK-KGQ-KVKLFRELLNFDVGTSTH-AVRNIDDVYV----ERAD--------------------VEAVK------------EILRKMG-S---GGLIYARS---SEE-------AEELYNSLKDE--FKVGLVTAQ--R----KKDFVLFERGEIDYLIGTAYYYGTLVRGLDLPERIRFAVFFKAPVFRVRIE------DI-D-----TISPGMVRVIALI-FKEDER-----------------VK-KFIP----------YLPKIT-E---------------------------------GTK-EFEELKSILKKVIAERKKEV------KDF---VL------------RE--GEV-IFPDVRTYIQGSGRTSRLFAGGITKGASFLLE--DD--EDVLKAFVERAR--YF--D-IEF------K-----------------KI------------DE------V-------DFESLIREINESREKF----RR--
>OYT60936.1 reverse gyrase [Desulfurococcales archaeon ex4484_217_1]
--------------------------------------------------------------------------MH----------------------------------------------------------------------------------------GIYRHGCINCGEEISD-LRLGYMLPCEKC-LPI-H-VE-DLKN----------------IVKTPSYIT----TIELTEKLGKL-------K----RLK-KLK--YILEEIKEFNKLFRKLI-GNVMWSAQETWAKRILKNESFSIVAPTGVGKTVFGIVASIYF-AK-K--------N-K----KSYIVVPTSPLVIQV---YNRLM-EF----AGK-------L-NE---PIR-------------VLSYH-AKL--SQKERK-NILEKIAN-SEF-D------ILVTTSKFLSTHFEE-L-KN--N-----KFHFIFIDDVDAILKS-SKNIDRVLILLGFTE--SDIQIA-------FKLIKLKR---ILA--QKTLSNQ-------ER---AKL-LRE----VN-K-------L-----------RRHVEYVSR--K------A-KG-VL--IVSSAT--GRPRGL-RVRLFRELLGFEAGTRSE-YLRAIVDTYL----KPDK-----------------SI-EEEVA------------SIVKVLG-K---GGLIFVPIDKGIEY-------AEELASFLRDK-GIRAKVFVSK---E---IKALEEFIRGEVDVLVGVATYYGVMVRGLDLPEIIRYAIFAGIPRFKFST-------KL-DE-PHPLNIMRALVILREV-LEKEE------DKEKV-DRLIVRMK-RFI--AIAPAA---VVSEIA-K--------KLK-ENK-----PPE--------TAAEK-MFYEALAIARSLLEKPEIKRKLKEL-KEI---AIV-EE-------KGK--MFI-LIPDIMTYIQASGRTSRMFVGGITKGLSVVIV--DD--ERLLYGLLRRTK--WFIED-IEW------F-----------------DF------------KT------I-------DLEKLLREIDEDRELVKAI-RA-G
>WP_017980954.1 reverse gyrase [Methanocaldococcus villosus]
-------------------------------------------------------------------------MVVP---------------------------------------------------------------------------------------MIFKEMCPNCNGEIES-ERLKIGV-CKKC-LKE-DKEV--------------------------EKTE----LCKKI---ENL-------K----DLS-YYC--KIWKEFKEFEKFTKSL--GYSLLSIQKMWAKRVLKNKSFSIVAPTGVGKSFFGILMSLYL-AK-K--------G-K----KCYIILPTTLLVKQT---YERLR-GL----DN---------------NID-------------VAVYH-SEL--SNKDKK-EMKEKIEK-GEY-S------ILITTSNYLAKNMP--------KN----KFDFIFVDDVDALLKA-SKNIDRTLMLLGFPE--DIINEA-------AKIIY-------LIR--------------------IGK-LEE----AMKKR------------------EKLKEKIKS--------IK-HG-CL--VIASAT--GKSYGD-RVKLYRELLDFEVGFGMN-KLRDVEDLYD------------------------NNFDLNRIL------------NYVKKFG-S---GGLIFVSLDYGIEK-------AKKIEELLIKN-NIKAKLIHSKD------KKGFEDFKEEKIDVLIGVASYYGVLVRGLDMPERVRYTIFYGIPKFKMKL----------KE---------YIENLKEKKQIKED------IDIKN-KD-------------------------------------------------------------------VKEIKKIIKEKL-------KIKN----F---SIR-KE-------DDL--Y-I-LFPDVKTYIQASGRTSRMTEFGLTKGLSVVLV--DD--EEIFEYLRKYML--FMY-E-SEF------K-----------------SV------------DE------V-------CLDEILKKIDDDRE---KI-KK-G
>WP_013683585.1 reverse gyrase [Archaeoglobus veneficus]
--------------------------------------------------------------------------MVE---------------------------------------------------------------------------------------AIYAGLCPACGGDLKT-SEAKTG----KC-S-R-N-------------------------------------------------------I--------PLCRFAGDEVVEEFIEFFRNAI-G-EPRAVQKFWARRILRGESFAAVAPTGIGKTSFGAAMALFL-AT-K--------G-K----KSYIILPTTLLVEQV---AESLA-KY----GEK-------A-GV---KVSLNNSDG-----ITVLYYH-GRM--GKAEKE-KFFELIQN---A-D------ILVTTTQFLSRHFES-I-KR--------TFDFVFVDDVDAILKA-SRNVDRVLMLLGFRK----------------------------------------------------T-KKG----WEGE------------------------------------AR--G-VL--MVSTAT--AK-KGQ-KIKLFRQLLNFDVGSSTH-AVRNIEDIAV----EKDD--------------------VETIA------------SILEMMG-T---GGIIYARN---TQD-------AEMLYEALKEK--FKIGIVTSG--R----KKDYELFESGEIDYLIGTAYYYGTLVRGLDLPERIRFAVFVGAPTFTVKLE------DV-E-----SASPGIIRILALI-FRDSEE-----------------VK-EYLS----------ILPVID-KP-------------------------------EHEK-ELAELRKILKKLVEEGKAKE------KDV---VV------------RK--GEV-IFPDLRTYIQGSGRTSRLFAGGITKGASFLLE--SD--EEVRNAFVERAK--HY--D-IEF------K-----------------RM------------EE------V-------NFEELIKEINESRVAF----RR--
>WP_015848816.1 reverse gyrase [Thermococcus sibiricus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYKGMCPNCEDKISD-ERLYKKHPCEIC-L-----ED-EITS----------------DTYFDLISG----IREGLRVRNRI-------K----QWE-GVY--SLEKKLIEAETLFKNAT-GFTFWSAQKTWVKRLVKGKSFSIIAPTGMGKSVFGAFMSIYY-AK-Y--------G-K----KSYIILPTTPLVTQT---IKRVK-TF----AEN-------T-GI---DVN-------------LAYYH-GNM--KKKEKE-EMIQKIQT-GDF-D------ILITSGQYLARNFD-LI-KD--K-----KFDFIFVDDVDAFLKA-SKNIDRSLILLGFNE--EMIQKA-------WEIIKLKK---LMA---KYLNGN-RKDKN-------EQ-LKE----LNKQ-------I-----------NIIEKEIREFKD--KN--K-IG-VL--IIASAT--GSARGD-RIKLYRELLDFEVGSGRS-ALRNVVDSYL----FPEN-----------------SI-EEHVK------------ELLKVLG-P---GGLIFVPIDQGIAY-------AERLTNYLQDL-GFKVELISAR---N---KKGLQRFENGEVDYLVGVATYYGSIVRGLDIPHLIRYAIFTGIPKFRFSI-------DL-EQ-PTIYRVLGLMSEVMDF-L-ENE------DRKNA-EKLHAQIR-RLI--RNIPQF---EILKIE-E--------ALA-EGL-----PLE-GF----SNHVLK-VFKEAVQFLRMILKKEDVLKRIEED-PFI---SLK-KE-------ENK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVIIV--DN--EKVFNGLKRQMR--WRFAE-FEM------R-----------------PF------------HE------L-------ELEKLLQEIDADREKVKFL-LE-G
>RLF16615.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIFKQACPNCKGDIGD-DRLLAGLPCHRC-LDD-KTAS-EILR-RAERGE-------------DLKRL----VIKALEDSGRL-------K----HYV-EAA--TPHLKVEEFNEFFKRAV-GYPLWSAQRTWAKRILTGRSFAVVAPTGVGKTLFGLAMSAYL-AS-K--------G-K----RCYIVSPTTLLVEQA---RKRLE-EI----IKT-------S-GL---NIR-------------LAYYS-AAL--HKADKE-EQVRRIKE-KDF-D------VLITTSSFLARKFNL-L-KK--C-----RFDFIFVDDVDAILKA-SKNIDRVLVLLGLSD--EIVEKT-------LELIKLRR---EVA---RAARHR--------EPN-----LEE----LRTK-------A-----------EELSKEVEKAVK--RR--K-LG-LL--VVSTAT--GRARGT-RVKLFRELLGFEVGSRAE-AIRNIQDLYA----KPRG-D----------------L-DDEVV------------DLVSKLG-G---GGLVFVPLDRGVEV-------AERVTQKLKER-GVKAELVYAK--GR---KEEIAAFAEGEISVLVGMASYYGLLVRGLDLPETVRYAVFAGVPKMRFTL-------DL-KE-AYPSRILQLLVDVKDA-L-SGD------EQTKA-LRLIGRMR-RLL--WRLTPA---AFEELR-K--------ALD-SGV-----EPP-SW----LRQAYY-TVKEAAEFVFQVLSREEVKAKLRES-SYL---SFT-EE-------EGK--VVV-TVPDVPTYIQASGRTSRLYAGGVSKGVSVVFV--DD--ERVFNGLVRQTR--WLAEE-VKW------A-----------------SI------------DE------V-------DLGALMKEVDEDRERIRRL-LR-G
>RLI78119.1 reverse gyrase [Archaeoglobales archaeon]
---------------------------------------------------------------------------MQ---------------------------------------------------------------------------------------ATYANLCPICGKDLSL-NEVNNK----IC-HHR-N-------------------------------------------------------I--------QLCRLSEDELFEEFLNFFEKTI-G-KPRKIQRMWAKRILRNESFAAVAPTGVGKTSFGVAISIFL-AL-K--------S-K----KCYILLPTTLLVNQV---VLKVE-EY----AKK-------A-GI---DVALNANTDKNLKSIKVAYYH-GTL--KKAEKE-RFFNVLND---A-D------LLITTTQFLSKHFDE-I-NT--------TFDFIFVDDVDAILKT-SKNVDRILKLLGFQY------------------------------------------------------KNG----WKSK------------------------------------TK--G-CL--MVSTAT--AK-KGR-KAELFRRLLNFDIGSSTF-TIRNIDDIAI----NSME--------------------INVLA------------KILTKMG-K---GGIIYAKD---GDE-------AEKLYEFLKDS--FKVGIVKAD--K----KKDFERFRNCEIDYLIGTAYYHGTLVRGLDLPEKIRFAVFYGCPTFRVRIE------DM-D-----NVSENVIKTLAYV-FQEHEE-----------------AK-RFLP-----------IAKLS-S-----------------------------------E-RLAELKNVLKQILENLTEKEIR-KK-EDV---VI------------TK--NEV-VFPDIRTYIQGSGRTSRLFAGGVTKGVSFLLE--ES--KEILNAFIERAR--YY--D-IEFE----IK-----------------EL------------DA------I-------EFNKLKREVDESREKF----RK--
>WP_069293458.1 reverse gyrase [Fervidobacterium thailandense]
--------------------------------------------------------------------------MR----------------------------------------------------------------------------------------ALYLGLCPNCGGTISD-ERLSFGNPCEKC-L-----PE-TVEN----------------AP----VER----IAELLEETGKL-------K----SWA-RLV--EMEKKCREAEEKFLQAT-GFPVWSAQRSWIKRVLKNQSFSIVAPTGMGKSVFGTFMSLMM-AM-E--------G-K----RAYIVVPTTTLVVQT---HRRLL-TY----AER-------L-GV---DVP-------------VVAYH-SSM--GSREKS-EALEKIAN-GSC-S------VLITSTQFLAKNFE-LV-SN--Q-----KFHFVFVDDVDAFLKA-SKNVDRALFLIGFPQ--ELLETA-------WELVNFRI---QMG---RYLLEN-TGDKRATSEN-LEK-IEE----ITKH-------I-----------EFLEEKIENFKK--EN--E-TG-IL--VVASAT--AKAKGN-RVKLLRELLGFEIGSGRS-MLRNVVDTYV----PVAE-----------------DV-LEQVF------------SIVNVLG-K---GGLIFVPVDQGVEM-------AQKVATYLCQK-GVQAGVVVHS---E---KKDIDKFERGEIDVLIGVATYYGLLVRGIDLPHVVRYVVFAGVPRFKFSL-------EP-ER-PDVVKLLGLLEDLLDI-V-DPS------EVKKV-ERYIEFLK-GLL--NR-------QTLQVK-E-------------------------------SRELK-KLEEIAQFIIGTLRRPEVIDKLEGS-RFV---AIE-HV-------NGK--LHV-KIPDVRTYIQATGRVSRLFVGGVTKGISVILA--DD--EKLLNGLVRQMR--WYYPE-FQT------L-----------------PF------------AS------L-------DVEKLMEEIDRDRKRVRDI-ME-G
>RLF77941.1 reverse gyrase [Thermococci archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCEERISD-ERLIIKHPCEKC-L-----ND-EVSV----------------DEYFTLLKS----VRDSLALRGTL-------K----EWE-ELY--RVESQLKEVESLFNRTT-GYHFWSAQKTWVRRLIKGKSFSIIAPTGMGKSVFGTFMAVYY-AS-K--------G-K----RSYIVLPTTPLVKQT---IRRIQ-EF----AEK-------A-GI---KLN-------------LVYYH-GEL--KKKEKE-AMKEKIAR-GNF-T------ILITSAQFLARKFE-ML-KE--N-----RFDFIFVDDVDAFLKA-SKNIDRSLLLLGFNE--EMIQKA-------WQLIRLRK---QIG---KLLRGRESEKKQ-------EE-LRN----TNGE-------I-----------SRVENEIKEFIKNHEN--E-IG-TL--VIASAT--GRARGD-RIKLYRELLGFEVGSGRS-ALRNVEDVYL----IPSK-----------------SI-EEHLE------------ELLPRLG-R---GGLIFVPTDQGIAY-------AEELAQKLRDK-GFNIELVSSR---S---KKALEKFERGEVDILIGMASYYGSIVRGLDLPHLIRYAIFTGLPKFKFSM-------NL-EH-PTIYRILGLISGIFDF-L-SDD------DRREG-EKIYARLR-RLI--QTMPQY---ELLKIE-E--------ALA-EGL-----PLE-GY----HNHVLE-VFKQAVEFLRNVLKKEEVLKKIEED-PFV---SLH-KE-------GET--LYI-EIPDVRTYIQASGRTSRLFAGGITKGLAISIV--DN--LKIFNGMRRQLK--WRFPE-FEW------K-----------------SL------------EE------L-------DLESLLREIDEDREKVKGV-IE-G
>OYT57693.1 reverse gyrase [Desulfurococcales archaeon ex4484_217_2]
--------------------------------------------------------------------------MH----------------------------------------------------------------------------------------GIYRHGCINCGEEISD-LRLGYMLPCEKC-LPI-H-VE-DLKN----------------IVKTPSYTT----TIELTEKLGRL-------K----KLR-KLK--HILEEVRKFNELFKKLI-GNVMWSAQETWAKRILKNESFSIVAPTGVGKTVFGIIASIYF-AM-R--------N-K----KSYIVVPTTPLVIQV---YNKLV-EF----IEK-------L-NE---PIR-------------VLSYH-AKL--SQKERK-NILEKIAN-SEF-D------ILVTTSKFLSTHFEE-L-KN--N-----KFYFIFIDDVDAILKS-SKNIDRVLMLLGFTE--NDIQTA-------FELIKLKR---RLA--QKALSNQ-------ER---IKL-LKE----VN-K-------L-----------RKYVEYASR--K------V-KG-VL--IVSSAT--GRPRGL-RVRLFRELLGFEVGTRSE-HLRAIVDTYL----KPDK-----------------SI-EEEVA------------SIVKVLG-K---GGLIFVPIDKGIEY-------AEKLSSFLRSK-GIKAKVFVSK---E---IKALEEFIRGEVDVLVGVATYYGVMVRGLDLPEIVRYAIFAGIPRFKFST-------KL-DE-PHPLNIMRALVILREV-LEKEE------DKEKV-DRLIARMK-RFI--AIAPAA---VVSEIA-K--------KLK-ENI-----PPE--------TAAEK-MFYEALAIARSLLEDPEIKRKLKEL-KEI---TIV-EE-------KGK--MFI-LIPDIMTYIQASGRTSRMFVGGITKGLSVVIV--DD--ERLLYGLLRRTK--WFIED-IEW------F-----------------DF------------KT------I-------DLEKLLREIDEDRELVKSV-RA-G
>RLI30513.1 reverse gyrase [Candidatus Bathyarchaeota archaeon]
-----------MWCSG---------------------------------------------------VGAEI--PL----------------------------------------------------------------------------------------AVFRNLCPNCGGEIDS-RRLDLRLPCRKC-LSL-P-DE-EILK-RL--------------GDSPSKSR----IAELLREAGTL------TE----RYE-RLA--RWEDRLEKLASLFSKAT-GYKPWGAQRLWARRAVMDRSFAMVAPTGSGKTTFGLVLAIYV-AL-E--------E-K---GKVYLLFPSTLLVQQA---HERLE-SF----IGR-------L-GV---KLE-------------VVSYH-ANL--TKKQAS-EAKERIAK-GEY-Q------ILITTSSFLARNFQL-L-EN--R-----RFHLIFVDDVDALLRR-SKNVDRVLKLLGFPQ--EVIDEA-------LMILELRS---KLR---RAL-----------RVG-GKE-LEK----IRNL-------L-----------DSAQERLQKFLS--RG--K-MG-LL--VVSGAS--IRARRTKRIKLFQELLGFQLGSRLE-MSRNVADLYT----HPKK-D----------------L-MAEAA------------ELAKRLG-G---GGLLFVPMHGGLPM-------AQELAKQLEKL-GIKALVYGKA---R---RRLLEAFKSGEVDVLVGVASSRSPLARGLDLPQRVRYAIFAGVPKIKISL-------EFREE-FKPYRAVILLARLRDL-L-NQR------ERRQA-DNYIERLR-RLS--PLLSPQ---EKQAIL-E--------AMQ-AGK-----QLK-GF----LGKAQK-LFSEVAQFLELVLSREEVRKALREN-PHL---SLV-EE-------NGQ--YFL-VVPDAVAYIQASGRTSRLYAGGVSRGLSVVLI--DD--DVAMQGLMREVR--WFAED-VEW------K-----------------SL------------DE------V-------DLEQLISEVDRDRELIAKI-LR-G
>WP_131007685.1 reverse gyrase [Methanococcales archaeon HHB]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------IIYKEMCPNCFGDIDN-SRLELGV-CKRC-LEE-DGRY--------------------------SKLD----LCRKLGDGRKL-------D----KLR-DYC--RIWNEFKEFEEFCKDL--GYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSFFGVLMSLYL-AS-K--------G-K----RCYIILPTTLLVKQT---YERAL-SL----MGD--------------KIN-------------VLCYH-SEL--NEREKR-EVKERIEE-KDF-Q------VLITTSNYLTRNMP--------NT----TFDFIFVDDVDALLKS-SKNIDRTLLLLGFNK--ELIDEA-------YKIIL-------LMK--------------------RKK-FDK----ALELR------------------EKLKKKVEN--------IK-HG-CI--VIASAT--GKSYGD-RVKLYRELLNFEVGYGIN-KLRDVVDIYD------------------------E-IDMGKVL------------DYVKLLG-S---GGLIFISQDYSLEM-------AEEIEDLLRKN-NIKAKVIHSKD------KEGFEDFKEGKLDVLIGVASYYGVLVRGLDIPEKIRYAIFYGIPKMKFKL----------RE---------YLEKIKESKEIK--------VDIEG-KS-------------------------------------------------------------------LEEIENILEKDL-------KLKN----F---SLR-VE------EGDI--Y-L-LIPDIKTYIQASGRTSRMTEFGLTKGASILLV--DD--WKLFESVKKYML--FNY-E-SEF------K-----------------GI------------EE------V-------NFEELIRKIDEDRK---KI-KV-G
>WP_013798746.1 reverse gyrase [Methanotorris igneus]
--------------------------------------------------------------------------MVP---------------------------------------------------------------------------------------IIFKNMCPNCHSDIES-LRLDKGLTCKNC-MED-DSV-----------------------------SN----ICKYLAEKNTL-------K----ALE-DYC--KLKNELKELEDVAERC--GFKLLSIQRMWAKRVLKNKSFSIVAPTGVGKSVFGMITAIYF-AT-K--------N-K----KSYIILPTTLLVKQT---YEKII-NM----ANK-------A-GV---EVN-------------VVAYH-SEL--SSEEKR-VAKEKIEK-KDY-N------ILITTSNYLSKNPI--------DD----KFDFVFIDDVDAFLKA-SKNIDKSLKLLGFSD--EIIKKA-------YNILY-------LIR--------------------KKK-IED----ALKER------------------EKLKEMISK--------IN-HG-CM--IVASAT--GKSYGD-KVKLYRELLDFEIGYGMS-KLRDVEDIYD------------------------ENLSMEKIL------------EYIKIFG-D---GGIIFVPIDYGLKK-------AEEIEEFLIKN-GIKAKLIHSKD------KKGFEEFKNGEIDVLIGVASYYGVLVRGLDIPERIRYCIFYGVPKFKIDL----------EE---------TLKKENE------N------ISIEG-LN-------------------------------------------------------------------EEELMELVKNTL-------KIKN----F---SLR-KE-------DNK--YYL-LIPDVKTYIQTSGRTSRMTENGLIKGASIVLV--DD--AEVFEGLKKYML--FMY-E-GEF------K-----------------RI------------DE------I-------DVEKLIEKIDEDRR---KL-KE-T
>RLI89272.1 reverse gyrase [Archaeoglobales archaeon]
--------------------------------------------------------------------------MIE---------------------------------------------------------------------------------------AIYASLCPKCGGDLST-REANRA----KC-E-R-N-------------------------------------------------------G--------ALCRFSGDALVDEFVEFFKKAV-G-EPRSIQLFWARRILSGESFAAVAPTGIGKTSFGAAMALFL-AT-K--------R-K----RSYVILPTTLLVEQV---AESMQ-SY----AER-------A-GI---DVGLNEEGN-----VCILYYH-GRM--GKEEKE-RFFQLLKQ---A-N------VIITTTQFLARNFEA-V-KQ--------VFDFVFVDDVDSVLKA-SRNVDRILMLLGFRK----------------------------------------------------G-KKG----WEGE------------------------------------AR--G-VL--MVSTAT--AK-KGQ-KARLFRQLLNFDVGSSSH-AVRNVEDIAI----NSES--------------------IETVR------------DILRRMG-S---GGIIYARS---GEE-------AEKLYELLKEE--FKIGIVTAG--K----KKDYELFEKGEIEFLVGTAYYYGTLVRGLDLPEKIRFTVFVGAPTFSVRIE------DI-D-----RASPSVVRILALI-FRDSEE-----------------VK-RFVP----------ILSIID-KP-------------------------------EHEE-ELVELRKILKRLVEGGEARE------KDV---IV------------RK--GEV-IFPDLRTYIQGSGRTSRLFAGGITKGASFLLE--DD--EDVLTAFIERAK--HY--D-IEF------K-----------------KM------------ED------V-------NFEELIGEINESRARY----RR--
>WP_048096113.1 reverse gyrase [Geoglobus ahangari]
--------------------------------------------------------------------------MIF---------------------------------------------------------------------------------------AKYENLCSICHSTLTD-EEIERK----IC-LKK-H-------------------------------------------------------T--------PLCAHYVDRLTEEFSEFFRKAV-G-EPRSIQLFWARRIFQKESFAAVAPTGIGKTSFGILMSLFL-AK-K--------G-R----RSYLLFPTSLLVAQA---AEKIS-DF----SEK-------L-GI---DVGMNEEGE-----ITVLYYH-GGM--KKAEKE-KFHELLRS-GKY-S------ILITTTAFLSRNFGE-I-RG--------TFGFIFVDDVDAVLKA-SRNVDRILHLLGFRK----------------------------------------------------T-KEG----WKGE------------------------------------AK--G-VL--MVSTAT--AK-KGQ-KVKLFRELLNFDVGSTTH-AVRNIEDIAV----EKDD--------------------VEELK------------SILRMMG-R---GGIIYAQS---SED-------AERIHEQLRDE--FRIGIVSSK--S----KKDYELFERGELDYLVGTAYYYGTLVRGLDLPEIIRFVVFVKAPVFRVRID------DI-D-----SISPNMLRVLALI-FREDER-----------------VK-RFVP----------YLNSLS-Q-----------------------------------S-QEQELRSVLKELVRGGQAVE----R-KDV---VV------------RE--SEV-IFPDIRTYIQGSGRASRLFAGGITKGASFLLE--GD--GDVLRAFIERAR--YY--D-IEF------K-----------------SK------------DE------V-------DFESLIREIDESRRRF----RE--
>RLI25801.1 reverse gyrase [Candidatus Bathyarchaeota archaeon]
MFLNVYTRKLYEYLLEKN--------------------------------------------------PSKI--MK----------------------------------------------------------------------------------------AVFKGLCPNCGGDIDD-ERASMGLPCRMC-L---P-DA-------------------------------------YLKHSNPLAYIHNPSQ----AYL-RLV--YESKQLEEFISFFEKAT-GSKPWAAQRVWARRIIAGRSFALIAPTGMGKTVFGSVFALFL-AY-K--------R-G---WRSYIVVPTALLAKQV---SERLL-SY----AER-------L-GL---DIK-------------ISYYH-SLL--TKKEAK-SRLEEIKN-RDF-Q------ILVTTLSFLNMKFEF-I-EG--E-----KFDFIFVDDVDSLLRS-SKSVDKVLMLLGFKQ--EDLEKA-------FNLMDLRT---QLG---RLLRSR--------RY---PE-SSK----LYDK-------M-----------VKLMEELEE--N--RK--N-VG-VL--VVSGAS--IRARRTKRVRLFRELLGFEVASRID-IGRNVVDLYI----ESE--N----------------L-EEEAY------------RLIQKLG-P---GGLVYIPMDLGAEY-------AERIKRYLVER-GINAEAYTRP---R---KRILEKFSQGVYDVLIGMASYRSPLVRGIDLPYTVRYALFIGVPKMLIDL-------DIRQR-FRISKAIILLANIREL-L-PER------DQLEA-LRLINELR-IAN--RIIPRE---LREEIA-K--------SIA-EGR-----PLP-SI----PERAKI-AVEEALEFLSDILSRPSVLKALEES-PYI---GLE-KR-------GEV--FYL-IIPDPVAYIQASGRVSRMYAGGVSKGISIVLV--DN--DRAFNGLMRETR--WFMED-IVW------R-----------------RL------------SE------V-------DLDKVIEEVDRDRRAIKDL-LE-G
>RUM43289.1 reverse gyrase [Desulfurobacterium sp.]
--------------------------------------------------------------------------MKI---------------------------------------------------------------------------------------AEFRRMCPNCGGTISD-ERLKEGLPCEEC-LKT-PI-----------------------HY-ET-PEE----ICLALG--DKL-------L----SFD-DIC--KIDSFTKDYSRFFKEKT-GFTPWSLQLTWAKRVALKKSFTMIAPTGVGKTTWGLVTSAYV-E-------------G----KVYILVPTKLLVLQT---VQKLS-------------------KL---TDR------------KIVAYT-G--------KK-KEKEAIQK-GEY-D------ILVTTTNFLYRNYEI-I-P---KP-----FNFVFVDDVDSLLKS-AKNVDKVLKLLGFTD--KDIDTA-------MKVIELKR---LIA-----------KL-G------NRA-GKE----LYEE-------V-----------KELESYLRK-RR--EE-IE--N-VL--VVASAT--SQPRSK-RVKLFRELLGFEVGKSAT-ALRNVEDILV----YT-----------------GRDR-LKSSV------------ELIKELG-G---GVFVFISSDMGKEY-------VEEVVKYLNEN-GITAISYEKF--T----PKEQEKFVEGEIQAVVGIASYRNPLARGIDLPQAVRYAVFLGVPKMEFGL-------KL-T--LSPSNLFGVLLAVREL-L-PQE------EQTKV-ASYLSFLK-KYL---------------------------GLK-EEN-----I-Q-------SSSVKE-RLGRIKSYLETYLNDPSFLEKVKES-ETV---SLK-EK-------DGE--LYI-VVGDAAGYIQASGRTSRMFAGGLTKGVSIMFV--DD--LKAFNSLRKRVH--IFLED-VSF------KVLNAEKGKEFSEKFGLPLI------------EK------E-------ELLKVFETVDRDRERVREI-LE-G
>PLJ77670.1 reverse gyrase [Thermofilum sp. NZ13]
----------------------------------MKLLL--T------------------------RKVEEN--IH----------------------------------------------------------------------------------------AIFREACPNCGGPITD-TRLNQRLPCYVC-LP-------------SSKSPRGLEEPVDLESYRSFLAS----VVRLLKETGKT-------E----RLG-YVL--KIEEELSEFTSFFEKAL-ASKPWSAQVTWARRVIKGSSFAVLAPTGVGKTVFGIIMALYM-VS-K--------G-R----RAYLILPTTTLLNQV---YKKTL-LF----SDR-------V-GV--NKDS-------------IVTYH-SGL--SQKERE-EALERIAR-GEF-S------LLLSTSHFLSHHFDK-L-SS--M-----SFDFIFVDDVDSVLKS-SKNIERILTLLGFSQ--EEISTA-------FEIVMLKG---KLA---YSQRNR-------------KQ-SEE----ATKE-------L-----------EELQRKLSTMLA--SKG-R-RG-VL--VVSTAT--GRARGV-RVKLFRELLGFEVGTRSE-QLRNVLDVYA----LV-TDG---------------KP-TESAI------------EIITKLG-S---GGLVFFPMGTPEEE-------LASVASELRSR-GIRAEYVYRR--VK---KGVLEQFSEGGLDVIIGIASYYGLLVRGLDLPQVVKYAVFVGVPRFKFRL-------KP-EE-LTPSRLLQLASNISQI-S-EKG------DRAEI-DRLIASVR-NRL--LQLDAN---QYRQVQ-E--------LYA-RGD-----ASG------RFSTLIR-NLLRLRSIVEKYLSDRKVLERLSAE-TAV---KLV-EE-------NGE--LYM-LIPDVFTYVQASGRTSRLYAGGISKGLSIVVE--QD--QVLLEKFMRSMR--FYSGD-SQW------R-----------------RI------------DE------I-------NLKEVIQEISKERDFIRRV-LA-G
>RLG52220.1 reverse gyrase [Candidatus Korarchaeota archaeon]
--------------------------------------------------------------------------MH--RLLHV---------------------------SLYSASKPKA--------------------------------------VGGLMKAVFDGLCPNCGGPISD-DRLMMGLPCEEC-LPQ-ATAG--------------SPG------------E----VAEALAARGRL-----------WGYG-RIA--QVWRELLAVDRVFKSGL-GHPMWALQRVWAKRVLLGKSFAIVAPTGVGKTTFGSLMAVYL-AS-K--------G-K----RSYIVLPSSILVRQV---SERIR-EY----AGR-------C-GI---QAR-------------LLAYY-SGM--KASEKR-EFQEKLAG-GEF-D------ILVTTDRLLASRYDD-L-KR--Q-----KFDFIFVDDVDALLKR-SKNLDRVLVLLGLSE--ELVQKA-------LE---------------SALDSS--------------------------E-------L-----------EKLVEEHSSELG------G-AG-IL--VFSSAS--ARRASKRRLMLLRSLLGFELGYRQG-YLRNIVDVAV----KPSG-----------------SV-DEEVV------------KVIKRFG-G---GVLVFTPMPYGREY-------AEKLAEYLKAS-GVKAELA------D---GKAVEKFSRGELDALVGIASHRSPLARGVDLPERIRYVVFAGVPRYELKL-------TA-EE-YHPARLYSLLSNLRLV-V-DER------QRARI-ERELERLR-SFLT---ASSD---AV-----E--------AVK-AGG-----ELT-GY----LAALKK-AIDRGRSLLKELIT-PELLEKIRES-KDL---AMR-AE-------GEE--ITL-VIADAAAYLQASGRASRLFPKGLSKGASILVV--DD--EKAYVSLVRRLR--WYIDD-LEF------K-----------------EL------------EE------A-------S--RVFAEIDEDRRLIKEL-KE-G
>WP_048091040.1 reverse gyrase [Geoglobus acetivorans]
--------------------------------------------------------------------------MIF---------------------------------------------------------------------------------------TRYENLCSVCNSSLFE-KEIEGN----IC-LRE-N-------------------------------------------------------K--------ALCLHHTDEVTSEFIQFFKKAI-G-EPRSIQIFWARRVFQNESFAAVAPTGVGKTSFGIAMALFL-AR-K--------G-K----KSYLIFPTTLLVDQT---VEKIS-QI----SEK-------V-GI---GVGFNRRSE-----ITVCHYH-GKM--KKSEKE-SFFEILRS-EDY-Q------VLITTTAFLSKNFGE-I-KN--------TFDFIFVDDVDAVLKA-SKNVDRILQLLGFAR----------------------------------------------------T-KDG----WKGT------------------------------------AR--G-VL--MVSTAT--AK-KGQ-KIRLFRELLNFDVGTTTH-SVRNIEDVVI----ESSD--------------------IDTLR------------KVLRRMG-S---GGVIYARS---TEE-------AEKIYESLREE--FRIGIVSAK--S----KRDYERFERGEIDHIVGTAYYYGTLVRGLDLPEKIRFVVFVKAPVFRVKFE------DL-D-----SLSHTMLRTLALI-FRDDER-----------------VK-KYLP----------YLNSLR-E-----------------------------------D-QINQLRSVLREILQRGDKCG------KDV---VI------------RE--NEI-IFPDVRTYIQGSGRASRLFAGGITKGASFLLE--DD--EPVRNAFIERAR--YY--D-VEF------R-----------------KF------------ED------V-------DFDTLIKEINESRRKF----LK--
>RLE88623.1 reverse gyrase, partial [Thermoprotei archaeon]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMWSAQRAWARRVIKKRSFAILAPTGVGKTVFGILLSLYL-AD-R--------G-E----RSYIVLPTTLLVRQV---WEKTI-SF----AEK-------V-GS---RAR-------------ILGYH-GRL--TRKEKV-EFRNRLLK-GEF-D------ILITTSQFLARNIEL-L-KN--I-----KFHLIFVDDVDALLKS-SKNIDRVLILLGFSE--DIIHCG-------LRLINLKR---EIA---YRISRR--------EEV-----SQE----RFLE-------I-----------ETLRREIEDFIN--SN--R-IG-VL--IVSTAT--GKVKGQ-RVKLFRELLNFEVGSRAE-FLRNISDIYV----LSSKEK----------------L-FEDAL------------NLVKKLG-K---GGLIFVPVDEGIET-------AKKLVEYMNSN-GIKAALVYAK---E---KGALEGFLRGEIDVLVGVAIYYGLLVRGLDYPEVIRYAIFVGVPRFKFSM-------LG-LE-PNPIRMLQLLTNIREL-L-KGD------DARFA-DRYIAYLR-RIL--ADLDRP---KLMLLL-E--------ALN-KGV-----KLV-GS----LGRVQE-RVHMIYKFIRELVEKEYIREKLKTL-PYV---SIE-ET-------DKD--IFI-RIPDAMTYLQAAGRTSRMFAGGISKGISIVIV--DD--EKLLSGLIRQTK--WYSED-VEW------K-----------------SL------------DE------V-------DLELLIKEVDRDRDIIRRI-LA-G
>OYT47011.1 reverse gyrase [Desulfurococcales archaeon ex4484_42]
----------------------------M--RFGMGLHEEI----------------------------REAELL------------------------------------------------------------------------------------------VYGRACPNCGGFISD-KRLRLGIPCSSC-LPE-IPRD---------------------L----SLKN----IFLTLKHSRRL-------K----RFK-ELY--DFNKTYNDLVSFFIKCV-GNEPWSIQKLWLKRVAKNASFAMIAPTGVGKTTFGVVVALYL-AM-K--------G-F----KSYIIVPTTTLAMQL---EKKIE-EL----SSR-------A-DI---IVR-------------YVVIH-SKL--KRGEKR-AREAKLLEPDGF-D------ILVTTSNYLLRNSDK-ILKH--------DFKFIFVDDVDAVLRG-SKAIDIILKLAGYDD--NDIEKA-------LKVIKLKR---ELA----------YRGED------PEL-LER---------------I-----------RSIENELEIKRR------R-LGKVV--IIASAT--GNPRGT-RVKLFKELMGFEIGARPE-FIRNIVDAYE----KL--RS-------------E-NV-IEQLV------------SLVKRLG-C---GGLIYVPIDKGIEY-------AEYLASKLRER-GVKAQAMHSK---N---IKAIKEFIAGELEVLVGVATYYGVLVRGIDLPETIRYVIFVGIPRHKIAL-------RL-KE-VKAQDILRLLPIIRDV-VSDDE------LRRKI-EGYIARMR-RLI--RRAGGY---VIERLN-Q--------ILS-GEK-----PPE-TR---GE----K-EFLEIYDLIKELTQKREIIEAMKKH-PEV---SII-EE-------NGE--LYV-LIPDAPTYIQASGRTSRLFLGGISKGLSIVLV--DN--NKLLKGLERRLR--WIIEE-FTF------T-----------------PL------------SE------V-------DVDELVKEINKDRELIKRL-RA-G
>RLI85826.1 reverse gyrase [Archaeoglobales archaeon]
--------------------------------------------------------------------------MIK---------------------------------------------------------------------------------------AIYSKMCQICGEDLDT-EEAVVG----IC-KRR-N-------------------------------------------------------E--------VLCRFREDYIVDEFMEFFKVIV-G-EPRAIQRFWARRILRGESFAAVAPTGIGKTTFGLSIALFL-AL-K--------E-K----KSYVILPTTILVKQS---VEVIK-RF----CER-------L-NL---DFSLNERGD-----LIILYFH-GNL--KKDERE-RFFKLLDE-GAF-R------ILVTTSQFLTRYFPS-I-KQ--------NFNFIFVDDVDSVLKA-SKNVDRILQLLGFQY--N------------------------------------------------SN-ERR----WKGK------------------------------------AT--G-CL--MVSTAT--AK-KGQ-KARLFRELLNFDVGTSTH-AVRNIDDVAI----NDES--------------------LDLLC------------EILRKMG-K---GGIIYARN---TDE-------AEMLLETLKSE--FKVGLVTAG--K----RRDFELFERGEIDYLIGTAYYYGTLVRGLDLPERIRFCVFYGSPVFRVRVE------DV-E-----SATVGVIKTLAMI-FRSYED-----------------VK-RFIP----------YLTVIE-R---------------------------------RPK-LLNELRSILKSLMEHGNVRE------RDV---VV------------RK--GEI-IFPDVRTYIQGSGRTSRLFAGGITKGASFLLE--KD--PEILNAFIERAK--FY--D-VEF------K-----------------SL------------DD------V-------DFGRLIKEIDESRERF----RR--
>WP_121170002.1 reverse gyrase [Thermovibrio guaymasensis]
--------------------------------------------------------------------------MKI---------------------------------------------------------------------------------------AEFYRMCPNCGGIISD-ERLKKGLPCEKC-LPK-EI-----------------------DY-SE-REE----ICSDLG--DNL-------R----RFE-ELC--SLDSFVKDYTRFFKEKT-GFTPWSLQIMWAKRVALKKSFTMIAPTGVGKTTWGLVTSAYL-K-------------G----KVYILVPTKLLVLQT---LDRLS-------------------KL---TDK------------RIVAYT-G--------KK-SEKEEIKS-GNF-D------VLITTTNFLYRNFEI-I-P---KP-----FNFVFVDDVDSLLKS-AKNVDKVIQLLGFTE--EDVNLA-------MKVIDLKS---KIA-----------SL-G------ERA-PKS----LFER-------L-----------RKYERYLER-RR--EA-IE--N-VL--VVSSAT--SQPRSK-RVKLFRELLGFEVGKSAS-ALRNVEDVLI----YT-----------------DKDF-LDEAV------------RLIKKYG-K---GVFVFISSDMGKDF-------VDVVVDRLNSS-GVPSVSYEDF--T----PENQEKFVNGEIWAAVGIASYRNPLARGIDLPQAVRYAVFLGVPKMEFSV-------RL-T--LAPVKLFGMLLVLRDL-F-PRE------EEPKV-ISYLTYLK-RYL---------------------------SLK-EEL-----LDK-------YPRIKG-KLEEIRSFLEGYLSDEEFLKKIKES-ETV---ILK-ER-------DGE--LYV-VVGDAAGYVQASGRTSRMFAGGLTKGVSLMFV--DD--LKALTSLRKRIL--IFLED-VNF------KVLSYGKGKELSEKFGFELI------------EE------K-------DLRRIFEVVDKDRERVRKI-LS-R
>RLE55573.1 reverse gyrase [Candidatus Verstraetearchaeota archaeon]
--------------MGKNAK--------------------SL------------------------EIMKER--VH----------------------------------------------------------------------------------------AVFKEGCPNCGGEIAD-IRLKNKLPCKLC-IPI-P-DD-KLIA-EISA-----------LNDVEKFKF----TLRLLKKFKTL-------K----KYA-SLA--KLEEEVARVNELFEKAT-GSRLWSAQRTWCKRALSGKNFAIIAPTGMGKTVFGIILSIYF-AS-K--------R-K----KAYIILPTSLLAYQV---CSKVK-EF----IEK-------L-NL---DIK-------------VVEYH-SIL--TRSKAK-RALEEIAE-GEY-D------ILITTSYFLPRHFEK-I-SH--R-----KFDLIFVDDVDSFMRT-SKNVDKVLILLGLKQ--EIIELG-------FRAMDLRT---RLK---KLLRMR--------RVY-NEE-LNR----VREE-------L-----------VKVESEIAEYKQ--KN--K-VG-LL--VVSGAS--IRARRTKRLRLFKEILGFELGGRAE-GVRNIVDMYT----KAS--N----------------V-VDKVV------------ELVKELG-G---GGLIYVPMDKGAAY-------VKKVAEALEAS-GIKVTTYERT---K---GKILEKYRKGEYEVLVGIASYRSPLARGIDLPERVRYAIFAGVPKIKISL-------DI-EE-FRPSRAIILLANLRDF-VETQK------EADMI-DKYIADLR-RFS--GMLRRD---EVERIV-E--------SIK-AGE-----KLE-GF----IGRVQE-LFIETANFLRELLSRENIRRKIKES-PYL---SI--EG-------EDK--PVI-VVPDVVGFLQASGRTSRMYAGGVSKGLAIVIV--DS--EKAFNGLVRELK--WYIED-VKF------I-----------------EL------------SR------E-------KLREVIREVDKDRETIRKL-RE-G
>OHD10217.1 reverse gyrase [Spirochaetes bacterium GWB1_36_13]
--------------------------------------------------------------------------MNQ-----------------------------------------------------------------------------------YHIHGSYDYFCPNCGNSNDD-GRNISKHPCPVC-ISE-FHENIQEDE-----------------------------IVKELKKNKTL-------K----NYS-SIV--ELNIKLKEYTKIFSKII-QSEPWSIQRTWFKRIVQGKSFTALAPTGIGKTTFGIITALFL-SH-E-------EK-K----KSVILCPNSVLLHDI---VDRLN-EYK---------------TL--IKAK-----------TEVLYYT-SKF--SPKKKL-EFEERVKN-QDY-D------ILVITNQFLSRKFVL-L-EGT-------FYDFLFADDTDALLKA-SGNIDRILKMIGFSQ--EDLGKA-------FEYIKSSF---KYS---------------------KNS-SDE----TFVQA-----------------HKVLKDDVTGIKNT----KK-IG-TL--IISTAT--GKGRGM-RPKLFKALLSFDIGGKVE-GGGRIADLID----EDDS--------------------EKNLL------------QYIKKMG-R---GGLVFIPISKGTAY-------AEIVTAMLKKN-KIKAVLAESG--KM---NKIIKDLKEGEIEIVVGVSTHYGLLVRGLDLPETIRYAIFLGVPNFKFSV-------NMQEQ-ANSFQLIRILGALSYV-LEDKEK-----------ERVEKQLR-------------------------------TLK-KNS----FSPK--------------VIEHSYKIAQEYYTKPEVIESLKKS-DEI---VFK-EE-------DGN--RFM-LVPDISTYIQASGRTSRLFLEGFTQGISLVLE--SD--KRMAHFLSRRMK--WLQDR--AFI-----------------------PL------------KD------A-------NLDDLIEKVNIDRDKVRNL-KQ-S
>WP_132525047.1 reverse gyrase [Phorcysia thermohydrogeniphila]
--------------------------------------------------------------------------MKI---------------------------------------------------------------------------------------AEFHRMCPNCEGIISD-ERLKAGLPCESC-LKE-KI-----------------------NY-RN-PSE----ICKALG--DKL-------L----NFE-DIC--KLDAFTEDYSRFFKEKT-GFTPWSLQLTWAKRVALKKSFTMIAPTGVGKTTWGLVTSAYI-D-------------G----KVYILVPTKLLVLQT---VQKLS-------------------KL---TDK------------KIVAYT-G--------KK-KEKEAIQS-GDY-D------ILITTTNFLYRNFDI-I-P---KP-----FDFVFVDDVDSLLKS-AKNIDKVIKLLGFTD--EDVNTA-------LRVIELKG---LAA-----------KL-G------SKA-DKK----IYEE-------I-----------KELEERLLE-RR--KE-IE--N-VL--VVASAT--SQPRSK-RVKLFRELLGFEVGKSAT-ALRNVEDVLV----YT-----------------ESNH-LAKAV------------EFIKEFG-S---GVFVFTSADMGREY-------VDEVVEFLNRN-GINAISYERF--T----PEGQESFVKGEIQAAVGIASYRNPLARGIDLPQAVRYAIFLGVPKMEFSI-------KL-T--LSPSKLFGVLLAIREL-L-PQE------EQTKV-ASYLSFLK-KYL---------------------------GLK-EET-----I-K-------SSTVKE-RLEKVKEYIESYLSNPEFLEKVKKS-ETV---SLK-EK-------EGE--LYI-VVGDAAGYIQASGRTSRMFAGGLTKGVSIMFV--DD--LKAFNSLRRRVH--IFLED-VSF------RVLNVERGKELSEKFGLPLI------------EK------E-------ELLKVFETVDRDRKRVREI-LE-G
>RJX15398.1 reverse gyrase [Candidatus Bathyarchaeota archaeon]
---------------------------------------------------------------------MET--VH----------------------------------------------------------------------------------------AYFKGVCPNCDGEISD-LRLSMGAPCNLC-LPV-E-DE-KLIQ-DFKK-----------EDLISFKKN----ILSLLKKFETL-------K----NYE-KRL--FLDVEVEKLDDLFFKAF-HSRLWSAQRTWARRLLSGKSFTIIAPTGMGKTVFGMFISTFL-AK-K--------G-L----KCYILLPTTLLVSQV---SKKLL-DL----LES-------L-GL---DIP-------------VATYH-SML--TKKESQ-TEISKIMD-GKF-K------ILLTTPTFLSRKFSL-L-EG--K-----KFDFLFVDDVDSFLKS-SKNIDKVLMLLGFNQ--EIIEKT-------FLLIKLRS---ELR---KLLRQK--------NV--ETE-ISR----VREQ-------I-----------LDLENQIRKFVS--KN--K-LG-TL--VVSGAS--IRARKTRRIMLFRELLGFEVTSKVE-VLRNIEDLYL------EKGD----------------L-KLDLL------------KILKVLG-G---GGLIFVPMDKGTSF-------AEEVTNYLLEN-GVKATIYKK----Q---KKLIDDFISGKYDVLVGVASPRSPLVRGLDLPERIRYVIFVGVPKFRISL-------DI-KE-FRPEKARILLANLREF-L-SEE------EQAKV-DKYMVNLR-RYS--TMLRKE---EILEIV-E--------AMK-TGR-----KLE-GF----FGVVQQ-VFMDVSSFLEDVLEREEVKRKIKES-PYL---SSE-VV-------EGK--LYL-IIPDSVAYVQGSGRASRMYAGRISKGLSVLLV--DD--EKAFKGLLKELK--WFIED-LEL------K-----------------NF------------DE------V-------DIQKILEEVDRDRENIRKI-RE-G
>RLG99782.1 reverse gyrase [Candidatus Bathyarchaeota archaeon]
----------------------------------------------------------------------MGVALR----------------------------------------------------------------------------------------GIYYGLCLNCRGPISD-ERLLQMGICKKC-L-----EK---------------------TEGLKGWKQ----ILKRLEENGKL-------Y----FAG-EIL--EFHEKLKDFSSFFKKAI-GQRMWALQETWARRILLNRNFSIVAPTGVGKTVLGIVSALYF-LS-K--------G-K----RSYIIVPTSLLVQQT---VEKME-VF----AKR-------L-KI---NPR-------------LVYYH-GAL--KESEKR-EILEKIAK-NDF-E------ILVTTDRFIVNRFEI-L-KN--K-----SFDFIFVDDIDSFLKS-PRNIDKILTILGFNE--EIITLA-------FQLLDLRV---EAN---RLARMG-------------KD-ATS----ILRK-------I-----------EQIRKEIEYYKS--KN--R-IG-LL--VVSGAT--VKARRTKRIKLFEELLGFQIGFKPE-FLRNIKDFH-----LKRRYE----------------I-ERHVL------------ELVKELG-G---GCLVFVPSAIGKEY-------AIKLNDYLNQN-GISAYVYRKM---D---EKILEDFRNGKYEVLIGIASFRSPLARGLDIPERVRYVIFTGVPRMEIPL-------SW-EE-YNPTKILTLLKNIREF-L-ERK------QQERA-SEIIARLR-RIIP---LSKE---IQEKVK-E--------AIE-AGV-----QLE-GF----EEFARK-IIFDSRNFLKEVIT-PQMIGRIMKS-REI---SIK-KK-------EDM--FYL-IVADPVAYVQASGRASRMFAGGITHGASLLIV--DD--EKAFYSLQQRLK--FMLAD-ISW------S-----------------KF------------KP------E-------TVKKWFEKIDGDRRIIREI-RE-G
>RLG41642.1 reverse gyrase [Candidatus Korarchaeota archaeon]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------AVFRRLCPDCDEDLVT-HGDACA----SC-LPR-S-------------------------------------------------------R--------VWK---VRELLRQYEEFFRACV-GSAPWSVQRTWAKRVLLRESFAMLAPTGVGKTAFGMVTSLFH-RA-R--------GWG----RSYVILPTILLVRQV---KADLE-VY----AAR-ARESGLL-DA---E-------------PRIVAYW-GGM--KKAERE-ETLRAIES-GEF-D------ILVTTSQFLSRNLDL-L-LG--K-----EYAFIFVDDVDSLLKT-SKNIDRVLMLVGFTQ--EEIARA-------L----------------------------------RDP-TYR----PERR------------------------------------PE--G-IL--VLSTAT--GR-PGP-RAILFRRLLGFDIGALRGTTLRNVED-VV----ARGG--------------------LERVR------------EILERMG-G---GAILLLAD---MSL-------ADRVRAEAESA-GLRAEVVSGS--E----EEAIRAFADGELDVLIGAAKPYGVLVRGIDLPERIRYAVFAGTPRFTATLA------DV-AE-LSERALATFLGILSPV-LGARAV----------------ALS-RRLR----------L----G-RA--------------------------------AEG-EVQEARSLVERVFREPELLERVSRM-STI---VVE-EV-------EGA--VRL-SIPDVRTYIQGSGRTSRLYPGGLTRGAAFLVD--DG---PILDAFVRRAS--AY--E-LEF------K-----------------SI------------EE------V-------DLEALKAEIDRDREMVREAGRK--
>RLE56432.1 reverse gyrase [Candidatus Verstraetearchaeota archaeon]
--------------------------------------------------------------------MQQE--VY----------------------------------------------------------------------------------------AIFRKQCPNCGGDISN-LRLELKIPCEKC-IPI-P-DK-ELLQ-SLPL-----------NNVRETRRR----ILELLKKNGTL-------N----RYN-RIL--EVEEKVDRLNDLFEKIS-GSTLWSAQRTWCKRAFEGKSFSIIAPTGMGKTVFGIMLSLYI-AM-E--------K-K----RAYIILPTTLLAQQV---HEKIE-EY----KSK-------L-DL---KIK-------------IKAYY-TSI--AASRKK-DILKQIFE-ENY-Q------ILVTTSNFLSRYYEK-M-RD--R-----RFDLIFVDDVDSFMKT-SRNVEKVLKLLGLDQ--EIIELG-------YEAINLRR---KIK---RIYGRR--------RLN-KKE-LEN----LNKK-------L-----------ENIRKRIEDYKR--KN--K-IG-VL--IVSGAS--IRARRTRRIQLFRELLGFEIGGRME-GIRNVEDMYI----MAKKGN----------------I-AKHVL------------KLVKKLG-S---GGLIFTPMDKGREY-------MKKITEELEKN-GIKVESVERP---R---RKLLMKFRKGEYDILVGMASYRSPLARGIDLPERVRYAIFAGVPKIKIAL-------NI-DE-FNPFKAIALLANLRDF-TKRKS------ERIKI-DNKIIELR-RYS--WMINEK---QWEMIR-E--------AIE-KKV-----KLE-GF----LGKMQR-IVEETVNLIKNMLKREDVRKGIKKS-SYL---DI--EE-------GEK--VSI-IIPDIVGYLQGSGRTSRLYAGGISKGIAIIIV--DN--VKAFNGLKRGLK--WYLED-VSF------S-----------------RV------------NE------K-------RIKETMKKVDEDREKIRRM-RR-G
>TDA39572.1 reverse gyrase [Candidatus Verstraetearchaeota archaeon]
----------------------------------------------------------------------MVVALR----------------------------------------------------------------------------------------AVYCGLCLNCRGAISD-ERLLKFGICENC-L-----EN---------------------AEELRSWKH----VLKALEERGKL-------L----HVD-EVF--HFRDEFGKFSAFFRKAI-GHRMWSLQELWTKRILLKRSFSIVAPTGVGKTAFGTVAALHF-AA-G--------G-K----KSYIVVPTTLLVQQV---SEKID-LY----SQR-------L-GI---XLR-------------KICYH-SGL--VDEEKX-ELLDKVAR-FDF-D------ILVTTERFLISHFEV-X-RG--K-----KFDFMFVDDVDSFLRS-PRNVDRILTVLGFEE--AIVDAA-------LQLLALRR---EAV---QLKRMG-------------KD-CSE----VVGR-------I-----------ESLRGQIESYKE--RN--S-IG-LL--VVSGAT--MKARRTKRIRLFEELLSFQVGFKPE-LLRKIRDFY-----VEARRD----------------I-EGQVL------------SLVRSFG-P---GCLIFVPSVFGKDY-------VLKLGEFLNAN-GVXTNSSVKI---D---NELLDKFKSGEYDALIGVATFRSPLARGIDLPERIRYVVFTGVPRMEIKL-------SW-DE-YNPIKILALLKNIRGL-L-EEG------QRERA-SQIIHNLR-RITP---ISRN---TLEIVR-A--------SIE-SHT-----KLN-GY----EDYVKS-LIVEARDFLKGAIT-PKVIYGITQS-KEI---SLK-KT-------NGE--LYL-VVADPVAYVQASGRASRMFAGGITRGASFLLV--DD--EKAFYSLRRKLK--LILGE-STW------K-----------------RF------------DP------K-------TAENWLKKVDADRAVIREI-RE-G
>RLG75970.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------------MP-----------------------------------------------------------------------------------F----TVICRVCPNCEGAISS-ERLELGLPCEKC-LPA-C----DLRY-------------EEYLREKEKIKF----IYEKLLFKNKL--L---------KFK-KIY--DLETEFKDFLKFFKTIT-GKTPWSAQRTWAKRLIRGESFAIIAPTGVGKTTFLMVYSLYH-VA-K--------G-K---GKLYFIVPTKVLLKQV---YNGIL-DI----VNS-------S-SL---NIK-------------VLALG-CQQ--YHREKE-K--EILSK-GEF-D------ILLSTAAQLSRNFDK-I-AK--N-----RFTLIIVDDVDALLRN-SKNVDRVLQLIGFNS--DVINKA-------YRLVLDKI---ELV---KLLMTN----AQ------YDK-IEE----KKNK-------I-----------AKLRKEIEDYIK--GH--K-IG-QI--VVSSAT--GRSKGI-KAKIFKELLNFEAGTVVE-YMRNVVDTYV----YMDD-----------------DY-KKQIL------------DFIKNLG-P---GGLIFVSQDLGINV-------AKDLVQYLNKE-NIKVALASSS---R---RGYVEKFIKGDVDILVGVASYYGVIVRGLDIPDKIRYAIFLGIPKFQVAL-------DK-SL-NNPLKILSMLLVLEDI-I-N-D------DKDRI-AGYINRLR-KII--EKISYK---EYRLII-N--------SLR-ENI-----ALE-GF----LEKIRL-FLVEVKNYILSKVCIEDIKRKVKEN-NLL---ILR-EI-------NGK--LYV-VVPDVMTYIQASGRTSRMFANGMTKGLSIVIV--DS--EKVFKAFCKQLK--YYIDT-FEI------R-----------------LL------------SQ------V-------DLEKVVAEIDKDREFVKSI-LE-G
>RLE55265.1 reverse gyrase [Thermoprotei archaeon]
-------------------------------------------------------------------------MTL----------------------------------------------------------------------------------------ARYLNLCPNCGGPIDS-DRLEKGLPCSTC-LPT-ELED-RYQA------------LL------------------YLESSGRL-------K----LLR-DYL--ELNRQVNAFNEFFKAAL-GTSMWSAQRLWAKRIFKGKSFAVIAPTGSGKTTFGILMALYK-AS-K-------FG-E----RCLIVLPTSLLVEQV---YRKTV-AY----ASK-------L-GL---GVK-------------VVCYH-AML--SAKEKA-EAIKAIEE-GRF-D------VLIVTTMFISRNFEL-L-SK--Y-----RFDFIFVDDVDSFLKATSKNIDRVLLLLGIPK--RAIELG-------EELIRTLK---ELRKVSRIPSEK-------------SK-VTE----YQER-------V-----------VKLREEIRKELS--NR--K-IG-IL--VVSGAL--ARARRTLRVLLFREFLGFDIGSRME-YLRNIVDTYT----YLREGE---------------DI-FDKVL------------SVVRKLG-S---GGLVFVPPDQGKEF-------IVKLCEYLNQR-GIKAYAYIKP---K---RDVLDKFVAGEYDVLIGTATARSPLVRGIDLPQRVRYAVFTGVPKFKFTL-------NI-EE-FHPVRYMTLLHVLRDV-V-PRE------EADLC-DKYIAQLR-N-V--ALLRED---QLKQVL-E--------VIK-RGE-----KLQ-GF----LGYVQN-VIESVMKFVSELMSRPDVKEKIAKS-PYI---SLR-EV-------DGR--YVF-IVPDVTTYIQASGRTSRLYAGGVSHGLSVLIV--DD--EKAFNALKRELS--FILEE-IEW------K-----------------DF------------NE------V-------NLEEILKVIDEERDRIRAL-LE-G
>RLG54252.1 reverse gyrase [Candidatus Korarchaeota archaeon]
-------------------------------------MTKVYL----------------------------LARMIP---------------------------------------------------------------------------------------AVYKKLCPGYSLDLVT-HKPDE-----RC-SPE-K-------------------------------------------------------E--------LGD---LISLCDEFCSFFERCT-GFELWEAQRSWAKRVLQQQSFAAIAPTGIGKTVFGIIMSLFY-SS-K--------GWG----KSLVVVPTVLLVRQA---EERAN-AY----AKK-----G---GL---E-------------PRIVAYG-GIR--KVRERE-RLLETIKE-GNF-D------VLIITSQFLARRSDI-L-AS--N-----TFSFIFVDDVDSLLKN-SKNVDRVLVLLGFPH--EVVESA-------L----------------------------------RAV-KIE----RKGL------------------------------------PK--G-VI--MLSSAT--AR-PGR-RAILFRRLLGFDIGVLREGVLRNVEDIEV----PDKS--------------------KEILS------------KIAQMMG-G---GLLVYVPK---LEL-------VDEVIDALESA-GLRAEEVSGS--K----ETSIQAFASGELDALVGAAKPYGVLVRGLDLPERIRYAVFYGAPHFEFSLE------KL-EE-VSPRAIGTVLSTIAPL-LGRESK----------------LLS-LKLR----------S----G-RF--------------------------------VEE-DLARAKDLLSQILSNSEFWEKLSGL-GDV---VV--RY-------EDG--IKV-LLPDIRTYIQGSGRTSRLFPGGLSKGAAFLIE--EG---SLLNAFVKRAS--IF--D-IEF------K-----------------PI------------DQ------V-------NLESLKEEIDSHRKRIRELKGK--
>RJS92292.1 reverse gyrase [Candidatus Bathyarchaeota archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AFYNSLCINCKGSISD-SRLKTSGLCDNC-L-----EE-----------------------DIKRRDL----IVKRLTKRGNM-------K----EYG-ILW--DFWRKCEEFSEFFEKII-GNKMWTLQEFWMKRLLKEESFVIVAPTGIGKTSFGIVACLYL-AS-K--------G-K----RCYIILPTSLLVEHV---RSHME-TA----VKR-------L-GL---EVN-------------IAFYH-SGL--RGKEKK-RSMEEIEK-KEY-D------ILITTNRFLIRNFEI-L-----P-----SFDLIFVDDVDSFLKS-PKNIDKILMLLGFPE--DLVNKA-------LA--------------------G-------------ED-------------------V-----------EETRH----------------G-TL--IVSGAT--QRSRRTKRIRLFRKLLKFELGRKPE-FLRNMKDFYK----FVEGEK----------------L-KEETL------------RLIRKFG-D---GCLIFVPMNLGREF-------AKEMHEFLRNN-GVKSYVYEKM---E---AGMLRKFEEGDLECLIGVASYASPLARGIDLPERIRYTIFSGVPKFKVVL-------KK-SE-YNPSKLLIILKNLKDF-F-SEE------ERKDA-EKIIQRLR-RAVP---LKKE---ILEKIE-R--------EVA-E---------T-DF----ERYILN-IVKEAQSFLEKTLT-EDFLRRIEES-ERI---LLK-PE-------DGE--FAL-FIADPVAYIQASGRASRLYPRGVSRGASILLV--DE--KKAFNDLKRKCR--FFIEE-MIF------E-----------------EY------------DE------E-------KAEEWFERVDEDRILMREI-KE-G
>WP_013637986.1 reverse gyrase [Desulfurobacterium thermolithotrophum]
--------------------------------------------------------------------------MKL---------------------------------------------------------------------------------------AEFHRMCPNCGGIISD-ERLKAGLPCEKC-LPK-EL-----------------------FY-TN-RKE----ICNALG--NKL-------Q----DFK-KIC--LLDEFTENYVKFFKEKT-GFTPWTLQVMWARRVALSKSFTMIAPTGVGKTTWGLVTSAYL-S-------------G----KVYILVPTKLLVLQT---VEKLS-------------------KL---TNK------------KIVAYT-G--------KK-SEKGTIQS-GNF-E------ILVTTTNFLYRNFEI-I-P---KP-----FDFVFVDDVDSLLKS-AKNVDKVIRLLGFTE--EDISIA-------EKVLELKS---LVA-----------KF-G------EKV-DRK----LIEK-------L-----------KKLENFLEK-RK--SE-IK--N-VL--VVSSAT--SQPKSK-RVKLFRELLGFEVGKSAT-ALRNVEDVLI----YT-----------------DKDY-LEETV------------KIIKKYG-K---GVFVFISEDLGKDY-------VEEVVNFLNKK-GISTVSYENF--S----SENQGNFIDGKIQAVVGIASYRNPLARGIDLPQAVRYAVFLGVPKLEFNL-------KL-S--LAPVKLFGILLVLREL-I---E------DKTKV-MSYLSYLK-KYL---------------------------SLK-KEL-----LDK-------YPKVKE-KLEEIKGFLESYLSNKEFLEKVRAS-EDI---SLK-EK-------NGE--LFV-VVGDATGYVQASGRTSRMFAGGLTKGVSLMLV--DD--LKALNSLKKRLS--IFLED-LNF------KVLDYDKGKELAEKFGFELI------------DE------E-------KLNKIFKTVDEDRKRVKEI-LE-G
>RLG17432.1 reverse gyrase, partial [Nanoarchaeota archaeon]
--------------------------------------------------------------------------MR----------------------------------------------------------------------------------------GIYKKLCLNCEGSISD-ERLLQLGICENC-L-----ED---------------------IRKFRNLTQ----VLKELREKGKL-------K----FAG-PIL--NFQERLKDFSNFFKKLL-GHRMWSLQETWARRILLGKNFSIVAPTGVGKTVLGVAIALYF-AR-E--------R-K----KSYLVVPTGLLVQQI---LEKIE-NF----LPK-------L-DF---EVR-------------VVYYH-GAL--KKREKE-EALQKISN-GDF-D------ILVTTDRFMMMRFEL-L-KN--R-----GFDFIFVDDVDSFLKS-PKNIDRVLSVLGFDD--EIIEIG-------FQLLDLRK---EAS---KLARMG-------------KS-PER----VLEK-------I-----------ERYRRKIERYKQ--KR--K-VG-IL--VVSGAT--MKAKRTKRIKLFEEFLGFQIGFKPE-FLRNIRDFY-----IPMKKS----------------M-IEHVF------------EILKEFG-T---GCLIFVPSPLGKDY-------AIELNRELNER-GINSYVYRKM---D---ERILEKFEKGEYDTLVGVASFRSPLARGIDLPARIRYVIFAGVPRIEIPL-------SS-EE-FNPTKILTLLKNLRSF-L-SGS------QQEKA-TEVIMKLR-KIIP---LDKE---TQEKIR-E--------AIE-SGS-----SLK-GF----EEFAKK-IIVEARDFLKRVIT-PELIEKIANS-KEA---SIK-RE-------GGI--FYL-IVADPVAYVQASGRASRMFAGGISRGASILIV--DE--EKAFYSLQQNLR--FIIPD-ISW------K-----------------KF------------EL------K-------LARRWFERIDEDRRLIKEI-SE-G
>KYH38084.1 reverse gyrase [Candidatus Bathyarchaeota archaeon B24]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAYIHNPSQ----AYL-RLV--YESKQLEEFISFFEKAT-GSKPWAAQRVWARRIIAGRSFALIAPTGMGKTVFGSVFALFL-AY-K--------R-G---WRSYIVVPTALLAKQV---SERLL-SY----AER-------L-GL---DIK-------------ISYYH-SLL--TKKEAK-SRLEEIKN-RDF-Q------ILVTTLSFLNMKFEF-I-EG--E-----KFDFIFVDDVDSLLRS-SKSVDKVLMLLGFKQ--EDLEKA-------FNLMDLRT---QLG---RLLRSR--------RY---PE-SSK----LYDK-------M-----------VKLMEELEE--N--RK--N-VG-VL--VVSGAS--IRARRTKRVRLFRELLGFEVASRID-IGRNVVDLYI----ESE--N----------------L-EEEAY------------RLIQKLG-P---GGLVYIPMDLGAEY-------AERIKRYLVER-GINAEAYTRP---R---KRILEKFSQGVYDVLIGMASYRSPLVRGIDLPYTVRYALFIGVPKMLIDL-------DIRQR-FRISKAIILLANIREL-L-PER------DQLEA-LRLINELR-IAN--RIIPRE---LREEIA-K--------SIA-EGR-----PLP-SI----PERAKI-AVEEALEFLSDILSRPSVLKALEES-PYI---GLE-KR-------GEV--FYL-IIPDPVAYIQASGRVSRMYAGGVSKGISIVLV--DN--DRAFNGLMRETR--WFMED-IVW------R-----------------RL------------SE------V-------DLDKVIEEVDRDRRAIKDL-LE-G
>RLG62424.1 reverse gyrase, partial [Candidatus Geothermarchaeota archaeon]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPCDKC-LPK-IPND--------------L-----------SLKT----IYNELRSRRRL------RK----GFI-DIY--NLDKRLEEFSKLFKKAL-DSKPWSAQRTWAKRVFKGISFSIVAPTGVGKTLFGIMMSLYI-SG-V--------K-K--WGKSYILVPTTPLVKQV---YQKIC-EY----ADK-------I-GI---NVN-------------VIRFH-SKM--RVSEKR-EFYNKLIN-GDF-D------ILVSTNKFLSTRFDD-I-KN--N-----IFKFIQVDDVDAILRS-SRNIERILRLLGFDD--DTIKYS-------MEEILLKR---RLVRI-----------RD------PTE-REE----IIQR-------I-----------QEINKFLSGKRG------S-KN-IL--IVSSAT--GRPRGT-RVKLFRELLGFEIGLRSE-TLRNIYDVYQ----ITTD----------------RDA-KEILL------------ELIKKLG-N---GGLVYVPVDKGIEY-------AEEIADYLRSN-GVKADVFASG---R---YDVLDKFLNRELDVIVGVAIYYGVMVRGLDYPERIRYAIFLGTPRFRFSA-------RF-DD-PNPIQMSKTLTLLRDI-I--KE------DKGEI-DSMIRVLN-RIM--KTFTIA---QYKRIL-E--------VLK-GGR-----AAE--------TKLEF-RILDILEYIRDMLSRDWVREGLKKH-PDV---EIE-EK-------DGE--FYL-IIPDVMTYIQASGRTSRLYAGGITKGLSIVLE--DR--EKLIKTLIRRME--WIFEE-IKW------Y-----------------RL------------DE------V-------NLEKIVEEIDEDREMVRKV-RT-G
>WP_052884688.1 reverse gyrase [Thermofilum uzonense]
--------------------------------------------------------------------MEDNN-IH----------------------------------------------------------------------------------------AIFRELCPNCGGPVTD-QRLENRLPCQVC-LP-------------STKTLRGAPDNLSTPEYVSYMKD----LVLRLEKRGRV-------G----RLG-EVV--KLEEELSSFIDFFEKAV-GSRPWSAQVTWARRVLKGSSFAVLAPTGVGKTVFGLTMSLYL-AS-K--------G-G----KVYLVLPTTTLLGQV---YDKAL-QF----ASR-------V-GF--DRER-------------IMAYH-GGL--SPKERE-EVLDRVSR-GDY-S------ILLTTAQFLARNFEY-L-KG--A-----RFDFVFVDDVDSVLKS-SKNIDRILVLLGFSE--EEISTA-------LELVTLRA---RML---IMQRNR-------------KH-AEN----NADE-------L-----------EKLQSKLESMLA--RSG-K-KG-VL--VVSTAT--GRARGQ-RVKLFRELLGFEVGSRSE-QLRNVLDVYA----LS-SEL---------------DL-TDKAV------------ELVSTLG-P---GGLVFFPIGTPEDK-------LAKMVERLAAR-GLKAEYVYGK--AK---RNLLERFSSGEVGVLVGVASYYGLLVRGLDLPHVVKYAVFVGVPRFKFRL-------VP-EE-LTPNRLLQLASNLVSI-V-EKG------DAVEI-NRLVANIR-SRI--LQLDAS---QYRALQ-E--------LYM-QGV-----TNG------RYAFLVK-SLLRLRDLVVKYLSDPSVLERLSEE-TTV---KMF-RE-------EGQ--YYV-ILPDVYTYLQASGRTSRLYAGGISKGLSIILE--ND--AVLLEKFFRAIR--FYTGE-SQW------K-----------------KL------------EE------V-------DLGRTMEEVSREREVIKAI-IE-G
>AKG39437.1 hypothetical protein MA03_07680 [Thermofilum uzonense]
--------------------------------------------------------------------------MH----------------------------------------------------------------------------------------AIFRELCPNCGGPVTD-QRLENRLPCQVC-LP-------------STKTLRGAPDNLSTPEYVSYMKD----LVLRLEKRGRV-------G----RLG-EVV--KLEEELSSFIDFFEKAV-GSRPWSAQVTWARRVLKGSSFAVLAPTGVGKTVFGLTMSLYL-AS-K--------G-G----KVYLVLPTTTLLGQV---YDKAL-QF----ASR-------V-GF--DRER-------------IMAYH-GGL--SPKERE-EVLDRVSR-GDY-S------ILLTTAQFLARNFEY-L-KG--A-----RFDFVFVDDVDSVLKS-SKNIDRILVLLGFSE--EEISTA-------LELVTLRA---RML---IMQRNR-------------KH-AEN----NADE-------L-----------EKLQSKLESMLA--RSG-K-KG-VL--VVSTAT--GRARGQ-RVKLFRELLGFEVGSRSE-QLRNVLDVYA----LS-SEL---------------DL-TDKAV------------ELVSTLG-P---GGLVFFPIGTPEDK-------LAKMVERLAAR-GLKAEYVYGK--AK---RNLLERFSSGEVGVLVGVASYYGLLVRGLDLPHVVKYAVFVGVPRFKFRL-------VP-EE-LTPNRLLQLASNLVSI-V-EKG------DAVEI-NRLVANIR-SRI--LQLDAS---QYRALQ-E--------LYM-QGV-----TNG------RYAFLVK-SLLRLRDLVVKYLSDPSVLERLSEE-TTV---KMF-RE-------EGQ--YYV-ILPDVYTYLQASGRTSRLYAGGISKGLSIILE--ND--AVLLEKFFRAIR--FYTGE-SQW------K-----------------KL------------EE------V-------DLGRTMEEVSREREVIKAI-IE-G
>RKY30413.1 reverse gyrase [Candidatus Omnitrophica bacterium]
-------------------------------------------------------------------------MGIE---------------------------------------------------------------------------------------VRYVDLCKVCGKDLTD-EEIELS----FC-KRA-R-------------------------------------------------------K--------PLSFEPLDSLLDEFKDFFEKSV-GYPPRGIQVLWARRLLRKESFTAVAPTGIGKTTFGIIASIFL-AK-K--------G-K----KSYLIMPTSLLVQQA---RQLIE-KF----CIK-------V-GI---DCSFNSTDG----AVNIGYYH-GGV--KGEEKE-LFIQLVSE-EKF-H------ILITTTQFLSKNFATLL-KG--K-----SFEFIFVDDVDAILKA-SKNVERILNLLGFEE----------------------------------------------------T-EDG----WKGE------------------------------------AK--G-TL--MVSTAT--AK-KGK-KALLFKNLLGFDIGSAFY-TARNITDIAI----KSKD--------------------LNTIK------------KILRLMG-K---GGIIYTPS---TEE-------AQEVYESLKGE--FKIGIVTAK--T----KKDYESFKDGKLDYLVGTAYYYGTLVRGLDLPLRIRFCIFFGAPVLKVNIG------DL-S-----KVSVNLIKILAFV-LREEEE-----------------IK-PFLP----------FINNIE-R---------------------------------KKG-KLEGLIKAIQRILSRKEKIHL-----KDI---VL------------RE--NEI-IFPDIRSYIQGSGRTSRLFPSGLTKGASFLLE--GD--EEILEAFIKKAQ--FY--E-INF------C-----------------SM------------ED------V-------DWDKLKEEMERTRD-L----QS--
>RUM32456.1 reverse gyrase [Aquifex sp.]
--------------------------------------------------------------------------MIR---------------------------------------------------------------------------------------AVFENLCPNCGGEITS-ERLLKGIPCEKC-LPK-E---------------------------VE-REE----VC------SLV-------K--EGNFK-DFC--NLLEELRNWETFFKEKL-DTSPWSLQKSWARKVFLNRCFAMLAPTGVGKTTFGLSIASYL-A--E-------KQ-K----RSYIILPTQLLVEQT---AERLK---------R-------F-GV---NEE------------DVIVWG-KL---SEKKKK-LYKERIEK-GDF-K------ILITTSMFLYKNYEI-L-P---RD-----FSFIFVDDVDSFLKT-AKNVDKVLYLLGFSE--EDINKA-------FELIKLK--------------------EK------PKK-TDG----DWEE-------I-----------RKRTEELKE-IA--KK-RK--G-VL--AVSSAT--GNPRSN-RIKLFRELLGFEVGKPTF-FLRNIVDVYE----ET------------------QEL-DETLV------------KRVKEFG-K---GGLIFVSSDYGKEK-------VEEIKKLLEAN-GIKAITYEE----------KLESFEKGEVDVAIGISSFKNPLARGVDLPHVVRYALFYGVPKIKVPL-------KV-D--TSVAHLLWALLSIRPL-V-LKDEELKG-YIKKV-DNWIQKLR-RYS---------------------------FLS-EDF-----IER-------TPDLKE-RIENLTKEIQEFFKSEKVIEKIKNS-DEI---TLR-VS-------DEG--YEL-VVADITGYLQASGRTSRMYAGGLTKGLSYILL--DD--IKAFKNLEKKVR--WFNQD-IEF------K-----------------NA------------SQ------V-------DLEGIFKEIDEDREKVRKI-LE-G
>RMF30730.1 reverse gyrase [Thaumarchaeota archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------SIFKDLCINCGNEITD-ERLKLSMPCDKC-IDH-IIDE---------------------EDIIEKQIK----IGRYLEVNNKLM-----------NYA-KIY--NEAKAFREFEELFEKAY-GFKLRSAQKEWAIRFLREESFSIIAATGLGKTHFGIFASVFN-AL-K--------G-K----NSYIIMPTHLLVEQA---YSIAS-SI----IDR-------L-DL---KIK-------------IVKIH-SKM--KAKERE-ESIKALNK-A---D------LLITTSSFLARRFDD-I-NN--------KFNLIFVDDTDSLLKR-SKNAIRVLRLIGYKE--DEIKKA-------IDDIRTGK-------------------------------------------------F-------D-----------------EH-KS-KG-IV--IVSSAT--IKPRGI-APLLFRHLLGFDIGISLT-NVRNIVDTYT----------------------------NERID------------RLVKRLG-S---GGLIFVSIYDGEDS-------AIQIAELLKSK-GIKAEAYVSSN-AN---PKIFEKFRNGDIDILVGVATYYGMLVRGLNLPERIRYTIFTSVPKIRFRL----------SE------------------L----------NPNTT-NLFFTIFR-RYIP-----------------K------------------------RY---------K-DMDKSPELIKQILNDKEFLDAIRAN-PTM---KVT------------S--DSI-EMPDVRTYIQASGRTSRLYAGGVTKGLSVIIA--DD--LELLKALEFQLQ--WYFED-VQF------K-----------------EL------------KE------I-------DITRILKEIDEDRRKLSII-----
>RUM34651.1 reverse gyrase [Archaeoglobus sp.]
---------------------------------------------------------------------------ML---------------------------------------------------------------------------------------YIYRDLCPQCGGDLHS-EEAESG----FC-KNK-N-------------------------------------------------------I--------PLCHYSADIDVKEFLEFFREAV-G-EPTSLQKMWARRILSGESFAAVAPTGIGKTTFGIAMSVFL-AS-S--------G-K----RCYLLFPTSLLAEQS---FRKLL-EI----CEK-------T-KV---KFKVNCGDG---DGLHVMYYR--KM--KKTERE-KFFEELKE-GKD-S------ILITTSQFLVRNFSR-M-KC--------CYNFIFVDDVDSILKA-SKNVDRILQLLGFRY------------------------------------------------------AGK----WMGK------------------------------------AE--G-SL--MVSTAT--AK-KGK-KARLFMELLNFDVGSSYH-SLRNVEDIVV----EDDS--------------------VETLC------------NILDRMG-D---GGLLYTSS---REE-------AEEIYECLKDS--YKVGL-AGK--T----ENIYEEFESGELEYIIGTSYYYGTLVRGLDLPERIKFVVFINAPVFTIKVD------DV-D-----AVSDRMLKILRMV-FRIPDE-----------------LS-D------------------------------------------------------------EEAKEEIKRSMSVGKEIV----D-RDI---CL------------RK--GEL-IFPDIRTYVQGSGRTSRLFSGGITKGASFLLE--SD--RCIREAFLERSK--HF--N-IEF------K-----------------KI------------NE------V-------DFNKLRKEIEESRKGF----RR--
>WP_004590021.1 reverse gyrase, partial [Methanocaldococcus villosus]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNKSFSIVAPTGVGKSFFGILMSLYL-AK-K--------G-K----KCYIILPTTLLVKQT---YERLR-GL----DN---------------NID-------------VAVYH-SEL--SNKDKK-EMKEKIEK-GEY-S------ILITTSNYLAKNMP--------KN----KFDFIFVDDVDALLKA-SKNIDRTLMLLGFPE--DIINEA-------AKIIY-------LIR--------------------IGK-LEE----AMKKR------------------EKLKEKIKS--------IK-HG-CL--VIASAT--GKSYGD-RVKLYRELLDFEVGFGMN-KLRDVEDLYD------------------------NNFDLNRIL------------NYVKKFG-S---GGLIFVSLDYGIEK-------AKKIEELLIKN-NIKAKLIHSKD------KKGFEDFKEEKIDVLIGVASYYGVLVRGLDMPERVRYTIFYGIPKFKMKL----------KE---------YIENLKEKKQIKED------IDIKN-KD-------------------------------------------------------------------VKEIKKIIKEKL-------KIKN----F---SIR-KE-------DDL--Y-I-LFPDVKTYIQASGRTSRMTEFGLTKGLSVVLV--DD--EEIFEYLRKYML--FMY-E-SEF------K-----------------SV------------DE------V-------CLDEILKKIDDDRE---KI-KK-G
>WP_008287348.1 reverse gyrase [Hydrogenivirga sp. 128-5-R1-1]
--------------------------------------------------------------------------MSL---------------------------------------------------------------------------------------LIVERGCPNCGGAISD-ERLGRGLPCYRC-LPE------------------------------P-SDD----VCGALGSLHRL-------K----ALL-PFC--ETERRLSEFEKFFEKAV-GARPWSLQRLWAKRVFMGHSFAVVAPTGVGKTTFGLVSALFL-K-------------P----KVLLIFPTRILASQA---GNRLK-EL----SEK-------L-GV----DK------------NVLVYE-SR--------K-KVRERFLA-GDF-D------VLCGTNMFLHKNFEN-L-T---RF----SFSLIFIDDIDSFLKR-SKNVDNLFKLLGFSE--SELKLA-------LK---------------------------------ENK-TEK----DWER-------L-----------SKIRQR--K--------RD--T-VL--VVSSAT--LKPKGN-RVFLFRNLLGFEVQKAVT-TLRNIVDVAQ----PVKD---------------LQEA-LESSA------------DLIRRLG-R---GGLVYISVFYGKEK-------VNEVVEFYRSR-GLKAISYLDY--EP---KELYETLEKGDFDVAVGISHITNPLVRGLDLPHVIRYAIFLDPPKHMFPT-------EL-S--LQPSLLHSLLLTLLNL-F-SEE------DRLKA-VEYINYTR-RYL---------------------------TLR-EEL-----LDR-------YPRVKE-RLEEIKEFLDRYLSDEEFMGKIERS-EDI---SLV-RK-------EGK--LYV-VVGDANSYIQASGRTSRFIAGGMTKGLSVLFY--SD--PKAFNSLRRRLSAYFMQSD-VEF------K-----------------RL------------EE------I-------DLDKLLREIDEDRKRARLV-LE-G
>WP_012547331.1 reverse gyrase [Dictyoglomus thermophilum]
--------------------------------------------------------------------------MIE---------------------------------------------------------------------------------------AIFKGLCPNCGGDITA-ERLLAGLLCEKC-LPE-K---------------------------VP-QEA----LC------NHI-------K--EQDY--DLC--TLRKRYSEWEKIFRNFV-GFEPWELQKFWAKKLLLGRSFALLAPTGIGKTSWGLATSLYF-A--E-------KG-K----KSYIILPTRLLILQS---YEKLK-----------------G-KI---REK------------DLLVFGLDE---NKKEKE-EKRERLQE-GDF-K------ILITSSMFLYKNVDA-I-P---RD-----FAFIFVDDVDSFLKT-AKNIDKALYLLGFSE--EDINFT-------MSYIRMR----------------------------RNG-GDQ------EN-------I-----------KEVQEKVRE-IA--KK-AR--G-VM--VVSSAT--SNPKSE-RIRLFKELLSFDVGRPIF-YLRNVEDVYE----ET------------------NDL-NKTLV------------ERVKRFG-K---GGLVFLSSDFGKEY-------VDDIKNLLISE-GITAESYDNL--T----PEVLEKYQKGEISVLIGISSYRNPLARGLDLPEVIRYAIFYGVPKIVVNL-------DI-E--GNVRHLLVALASIRPL-I-ARDKNLEK-HIANV-DRWMKNLK-KYS---------------------------AVL-----------N-------PP--KD-KVDELRNTIKAFILSPEIYEKIKSA-DDI---AIR-EE-------NGK--WIL-VVSDITGYLQASGRTSRLYVGGISKGLSYILV--DD--RKVFNNLVRKSR-WWFSTD-IVF------K-----------------EA------------ST------V-------DIDDIFRQIDEDRERIRR------
>PNV79804.1 reverse gyrase [Fervidicoccus sp.]
--------------------------------------------------------------------------ME-------------------------------------------------------------------------------------KRLGIYMNQCPNCGGPISD-ARLNKGLVCEKC-LPK-VDRE---------------------V----TPKE----LLLLLYRKGSL-------K----ELK-SRY--EIEKETDNFMDLFEKAV-GWPPWSSQITWAKRVLQGTSFSIIAPTGVGKTVFGLIMALYQ-AK-K--------G-S----KSYLVFPTTPLVLQM---CEKLK-SF----NEK-------V-RAV-KDEE-------------IVCIH-GNM--KQSEKK-EALQKIEE-GKL-K------ILLSTSKFMINRSNQ-LSSL--------GFYFLFVDDVDSVLKS-KASIDATLKVMGFHD--EDIENG-------IELIRLKR---RMS----------YANGN------ASK---R----EEQT-------L-----------ENLSKKLKEAKE------R-VRSTL--VVSSAT--GGSRGM-RALLFRELLGFQIGGRTE-IFRNVEDVYN----EV--PD-------------K-EI-EEELY------------RIISLLG-K---GGLIYVPTDLGVEY-------AVKLTSWLKEK-GIRAEAFYSK---T---SKVLEAFQKGEIDVLVGVAVYYGVMVRGLDLPTIIRYAVFIGPPKFRFSF-------DL-TG-AHPINIVKLLSAIAEA-N-IPK------VSERA-KPLLLPLR-RAL--RRLSPA---ALQLLA-SD-----SPVTG-TLK-----EIQ-GE---LK---------KAKEFLKRTLEDNNVIEALKKT-GEI---FIE-IT-------PSG--KFI-IIPDAKTYIQASGRTSRLYAGGLTKGLAVTLITPKE--IPVLKSLERILS--FYTDK-FSF------K-----------------PI------------SQ------T-------DLNEILKEIDNDRRKLIDA-LE-G
>WP_121922588.1 reverse gyrase [Hydrogenothermus marinus]
--------------------------------------------------------------------------MKI---------------------------------------------------------------------------------------AEFHRMCPNCKGIISD-ERLKLGLPCEKC-LPN-EI-----------------------DY-TE-KKD----ICDALN--GKL-------K----EFK-HIC--WLEEFTEDFTKFFKEKT-GFTPWTLQIMWAKRVALKKSFTMIAPTGVGKTTWGLITSAYI-K-------------G----KVYILVPTKLLVMQT---VEKLS-------------------KI---TDK------------KIIAYT-G--------KK-QEKEEIQA-GNF-D------ILITTTNFLYKNFDN-I-P---KP-----FDFVFVDDVDSLLKS-ARNVDKVIKLLGFTD--KDIEIA-------LKLLDLKS---KVA-----------KL-G------EKA-NEK----LFET-------I-----------KKLETILEK-RR--KE-IN--N-VL--VVSSAT--SQPKSK-RVKLFREILGFEVGKSGA-SLRNVEDILI----YT-----------------DKDY-LEESV------------KFIKKYG-N---GVFVFISEDLGKDY-------VNVVVDYLNKK-GISTLSYENF--T----PENQEKFIEGKIQAVVGIASYRNPLARGIDLPQAVRYAIFLGIPKMEFSA-------NL-S--LSPIKLFGMLLVLRGL-I---E------DKTKV-MSYLTYLK-KYL---------------------------TLK-EEL-----VDK-------YPKIKE-KLEEIKNFIEIHLSNPEFLEKIKNS-EDI---SLK-EK-------DGE--LLV-VIGDATGYIQASGRTSRMFAGGLTKGVSLMFV--DD--LKALNSLKKRLS--FFLED-ISF------KVLDYDKGKELSERLGFELI------------KE------E-------DLNKIFEVVDKDRERVKEI-LE-G
>WP_052568328.1 reverse gyrase [Candidatus Korarchaeum cryptofilum]
-----------------------------------------------------------------------MIAMIP---------------------------------------------------------------------------------------AAFLGLCPG-SEIFKT-HERS------SC-L-E-E-------------------------------------------------------D--------LRA---ISEELKDYKKFFESCI-GSPPWEAQLMWAKRALARRSFAAIAPTGVGKTVFGLITGSYF-AH-K--------GFG----KSYMLFPTSLLVDQA---HYNLL-NY----SKC-------S-GK---Q-------------IRVISYR-SGM--KGKE---EFLSALES-GDF-D------ILLTTSQYLSANHEL-I-RKSVN-----KFSFIFVDDVDSFLKN-SKNVDKVLQLMGFDQ--EDIWNA-------M----------------------------------RGR---E----VEKR------------------------------------TD--S-VL--VVSTAT--GR-PGQ-RASLFRSLLGFEVGIMRPELLRNIADIYT----RER----------------------SELN------------SFMRRMG-S---GFLLFLAN---MDL-------ADEALELVESA-GFRGEVMHGY--E----EDKVRDFSEGRLDCLIGASKPYGVLVRGIDLPKRIRYVIFYGAPRFEITLR------EV-SE-MEDPSIISLFSSLSRA-LGSEER----------------KLA-MKLR----------R------NP--------------------------------SKE-DIGRARQIIEDILKDEEKISSISSL-ADV---II--DV-------RGR---RI-LIPDIRTYLQGSGRTSRLYPGGITRGASLVWD--ED---PVLTSFIKKAR--AQ--E-IDF------L-----------------HL------------RE------V-------DLEKLRSEIDESRRIISSL-KK--
>ACB07819.1 reverse gyrase [Candidatus Korarchaeum cryptofilum OPF8]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------AAFLGLCPG-SEIFKT-HERS------SC-L-E-E-------------------------------------------------------D--------LRA---ISEELKDYKKFFESCI-GSPPWEAQLMWAKRALARRSFAAIAPTGVGKTVFGLITGSYF-AH-K--------GFG----KSYMLFPTSLLVDQA---HYNLL-NY----SKC-------S-GK---Q-------------IRVISYR-SGM--KGKE---EFLSALES-GDF-D------ILLTTSQYLSANHEL-I-RKSVN-----KFSFIFVDDVDSFLKN-SKNVDKVLQLMGFDQ--EDIWNA-------M----------------------------------RGR---E----VEKR------------------------------------TD--S-VL--VVSTAT--GR-PGQ-RASLFRSLLGFEVGIMRPELLRNIADIYT----RER----------------------SELN------------SFMRRMG-S---GFLLFLAN---MDL-------ADEALELVESA-GFRGEVMHGY--E----EDKVRDFSEGRLDCLIGASKPYGVLVRGIDLPKRIRYVIFYGAPRFEITLR------EV-SE-MEDPSIISLFSSLSRA-LGSEER----------------KLA-MKLR----------R------NP--------------------------------SKE-DIGRARQIIEDILKDEEKISSISSL-ADV---II--DV-------RGR---RI-LIPDIRTYLQGSGRTSRLYPGGITRGASLVWD--ED---PVLTSFIKKAR--AQ--E-IDF------L-----------------HL------------RE------V-------DLEKLRSEIDESRRIISSL-KK--
>WP_011762985.1 reverse gyrase [Pyrobaculum islandicum]
--------------------------------------------------------------------------MD----------------------------------------VP-------------------------------------------HV--VYLHSCPNCGGPITS-DRLAAGLPCYEC-LPK-EPQ-------------------------AKAIGE----VVEALRRRKAL-------K----ELA-RVA--EYLREYNKFSAFFKEII-GYEMWGAQRLWARRLVRGKSFAIVAPTGSGKTTFILVATLYM-AL-R--------G-K----KTLLIFPTSALAHQA---YKKLM-SF----AEK-------V-GA---SVK-------------TLAYH-SLL--TEKEKD-EVLAAIER-GEF-D------VLIITSAFLPRRFDL-L-SR--Y-----KFEFIAADDVDSILRATSKNIDRILKLLGVSD--EVLKTA-------LDIISLTK---QIR---KAEV-V----GD------LKE-VER----LEQE-------L-----------SSARAKLQEEVR--KL--K-LG-IF--IASGAL--AKARRTTRLLLFRELLGFDVGGRAE-GLRNVTDVYI----DMSQ-----------------DV-VMQTI------------EILKRLG-P---GGIVYVQD---REL-------GIAIAEKAKER-GLSVEHFFKP---R---RGILESFEKGEIYALVGLASPRSPLVRGIDLPHVIRYVVFVGVPKYRFRV-------RL-EE-FSIPAYLTFLYNVRTV-L-TGE------LRYKA-DRLIGQLK-RLAP---YAI----SVQEAL-R--------KAS-EGA-----ELT-GF----DRHVVD-VVKSAVDFVNNLLMRDDLRQAIESS-TEV---KLT-RI-------DDE--FYV-LVPDVTTYIQGSGRTSRLYAGGLSKGLSVVIV--DD--KKVFHALKRELK--LRFDE-AEF------K-----------------HI------------DE------V-------DLNAVLAEIDKDRKAIRDI-LE-G
>RLG81778.1 reverse gyrase [Thermoprotei archaeon]
----------------------------------------------------------------------MDPNLK-------------------------------------------------------------------------------------NIHGLYRHACPNCHGVIDD-IRLSFKAPCTKD-LSD-DVFA-KIIK-EV-----------DIRDYYKLIRA----Y----ASNVKE------VK----YLK-NIL--EIEEKVKELEEFFSKATNGSRFWSAQRTWARRVLKGKSFSVIAPTGMGKTTFGLVTALYF-AI-------KNRG-NNS--KIYLVFPTTPLLKQA---YEKLL-NY----VDR-------L-SV---SV-------------RILAFH-GRM--SKKERE-VVLKSIDE-GEF-D------ILLTTSMFLHRYHEL-L-KK--H-----KYSFIMVDDVDAILRS-GKSIRLLLEILGFKP--EEIDAA-------LQLIKLRA---QLA----------------TRMN-EDE-KKK----IERE-------V-----------NKLERIVENARNRVKT-------VV--VVSSAT--GRPRGI-YPKLFRVLLGFEAGSRGE-AIRNIVDTYM----IPYK-----------------DH-LQQLL------------EIVRRLG-S---GGLVYVPVDKGIEY-------AEEIADYLRSN-GVRAEAFHSK--KN---IAILEGFMHGDIDVLVGVATYYGVMVRGLDLPERVRYAIFVGVPRHKFST-------RL-EK-PRPGDILRVLSILRDV-A-EGD------EKKRI-ELMIGRLS-SRL--RRLTQA---AVAKLG-E--------ELR-KAI-----SGE-PY---EKSPLLE-MLIDAWKQARELLARKDIQERLKQS-GDI---ALV-EE-------NGS--TYL-LIPDVATYIQASGRTSRLYPGGITKGLSIILV--DD--IRLLNGLIKRMR--WLFED-LEF------K-----------------PF------------DQ------I-------DLKKILEEIDKDRERVRKI-LS-G
>RSN69476.1 reverse gyrase [Candidatus Korarchaeum cryptofilum]
-----------------------------------------------------------------------MIAMIP---------------------------------------------------------------------------------------AAFLGLCPG-SEIFKT-HERS------SC-L-E-E-------------------------------------------------------D--------LRA---ISEELKDYKKFFESCI-GSPPWEAQLMWAKRALARRSFAAIAPTGVGKTVFGLITGSYF-AH-K--------GFG----KSYMLFPTSLLVDQA---HYNLL-NY----SKC-------S-GK---Q-------------IRVLSYR-SGM--KGKE---EFLSALES-GDF-D------ILLTTSQYLSVNHEL-I-RKSVN-----KFSFIFVDDVDSFLKN-SKNVDKVLQLMGFDQ--EDIWNA-------M----------------------------------RGR---E----VEKR------------------------------------TD--S-VL--VVSTAT--GR-PGQ-RASLFRSLLGFEVGIMRPELLRNIADIYT----RER----------------------SELN------------SFMRRMG-S---GFLLFLAN---MDL-------ADEALELVESA-GFRGEVMHGY--E----EDKVRDFSEGRLDCLIGASKPYGVLVRGIDLPKRIRYVIFYGAPRFEITLR------EV-SE-MEDPSIISLFSSLSRA-LGSEER----------------KLA-MKLR----------R------NP--------------------------------SKE-DIGRARQIIEDILKDEEKISSISSL-ADV---II--DV-------RGR---RI-LIPDIRTYLQGSGRTSRLYPGGITRGASLVWD--ED---PVLTSFIKKAR--AQ--E-IDF------L-----------------HL------------RE------V-------DLEKLRSEIDESRRIISSL-KK--
>WP_022846988.1 reverse gyrase [Desulfurobacterium sp. TC5-1]
--------------------------------------------------------------------------MKT---------------------------------------------------------------------------------------AIFHNLCPNCQGDIGS-DRLEMGLPCVMC-LSD-VD-----------------------EP-NS-REK----ICELLK--EKG-------N--LKYFK-IVC--DVLHFTEKFASFFREKT-GFIPWSLQVTWAKRVALGRSFSLIAPTGIGKTTWGITTAAFL-K-------------G----KSYIVVPTRILVQQV---YERVK-------------------EI---TDR------------EVVAYT-G--------KK-KEKERIFS-GDF-E------ILITTTNFLYKNWEQ-I-P---SG-----FEFVFIDDVDSILKS-GRNIDKVLRVVGFSE--EALSTA-------MEIVDVKR---KLV-----------AASS------DRF-KER----LLRR-------L-----------NYLERRLKP-LK--ES-VK--T-VL--VVSSAT--ASPRSR-RIKLFRELLDFEVGKTGT-SLRNVEDVAV----FT-----------------EASP-LDEAL------------DLIKTFG-K---GVFVFVSEAYGKEF-------VDDVVSYFRRQ-GISALSYEDF--S----VDRFDEFRKGSIEAVVGIASYRNPLARGIDIPDAVRYAVFIGVPRMKFPF-------EV-S--LSPSRLFTFILVCREF-L----------EQDKV-TAYLPFLK-KYL---------------------------TLT-EEK-----LDN-------YPSVKK-KVEEIAEYLRRKLSDRDFIEKIKKS-DSV---FLE-EE-------NGR--LFL-VVGDSAGYIQASGRTSRMFAGGLTKGVSFLIV--DS--MKAFNSLRKRLL--LFLED-VNF------RVLETDKGKEIALKKGFGLI------------TV------G-------ELKKIFEQVDRDRERVKAI-LE-G
>WP_125741010.1 reverse gyrase [Candidatus Korarchaeum cryptofilum]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------AAFLGLCPG-SEIFKT-HERS------SC-L-E-E-------------------------------------------------------D--------LRA---ISEELKDYKKFFESCI-GSPPWEAQLMWAKRALARRSFAAIAPTGVGKTVFGLITGSYF-AH-K--------GFG----KSYMLFPTSLLVDQA---HYNLL-NY----SKC-------S-GK---Q-------------IRVLSYR-SGM--KGKE---EFLSALES-GDF-D------ILLTTSQYLSVNHEL-I-RKSVN-----KFSFIFVDDVDSFLKN-SKNVDKVLQLMGFDQ--EDIWNA-------M----------------------------------RGR---E----VEKR------------------------------------TD--S-VL--VVSTAT--GR-PGQ-RASLFRSLLGFEVGIMRPELLRNIADIYT----RER----------------------SELN------------SFMRRMG-S---GFLLFLAN---MDL-------ADEALELVESA-GFRGEVMHGY--E----EDKVRDFSEGRLDCLIGASKPYGVLVRGIDLPKRIRYVIFYGAPRFEITLR------EV-SE-MEDPSIISLFSSLSRA-LGSEER----------------KLA-MKLR----------R------NP--------------------------------SKE-DIGRARQIIEDILKDEEKISSISSL-ADV---II--DV-------RGR---RI-LIPDIRTYLQGSGRTSRLYPGGITRGASLVWD--ED---PVLTSFIKKAR--AQ--E-IDF------L-----------------HL------------RE------V-------DLEKLRSEIDESRRIISSL-KK--
>RZN56187.1 reverse gyrase [Candidatus Verstraetearchaeota archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYNGLCLNCNGEISS-ERLFQSGICEKC-I-----DS-----------------------DIKDRKK----ILKILKENGKI-------L----YAE-KIF--NFYENFQNFSLFFKKVL-KQKMFSLQEMWAKRVLSNKCFSIVAPTGVGKTVFGIISALYF-AN-I--------G-K----KSYIIVPTTLLVQQI---VEKIQ-IF----SSN-------I-GK---NFN-------------IVYYH-GLL--GDKEKK-EAIKKILE-GNF-D------ILITTDRFIITKSEE-L-KG--I-----KFDFVFVDDVDSFLKS-PKNIDKILLLLGFDL--DIINLS-------MRLLE-----------------------------------TK----DIEE-------K-----------EKIREKIREYKN--NN--K-IG-IL--VVSGAT--LKAKRTKRIRLFEELLDFQVGFKPE-FVRNIKDVY-----IDKSKN----------------I-EEHVL------------DLIKEFG-S---GALVFVPQSLGKEF-------ADYINEYLLSN-GIKSYVYKKP---E---ENILNDFQNGKYDVLIGIASFRNPLARGIDLPERVRYVIFAGVPRMEFKL-------SW-EE-YHPTKLLTILKNIRPF-I---K------DELNA-NRIINNLN-KIIP---MKAE---LIEKIK-E--------AIE-TNK-----KLE-GF----EAYAKD-VIIEAREFLSKNIT-PELIELISKS-KEI---AIE-KR-------ENY--FYL-IISDAIGYIQASGRCSRMFAGGVSRGISFVIK--DD--EKAFYSLGQKLN--IILGE-FSW------S-----------------KF------------NL------E-------RIKKWFKKIDEDREIIKNI-RE-G
>WP_089322733.1 reverse gyrase [Desulfurobacterium atlanticum]
--------------------------------------------------------------------------MKI---------------------------------------------------------------------------------------AYFRRMCPNCGGIIGD-DRLSLGLVCEKC-LPD-AE-----------------------KE-IT-IRE----LCSILK--KKS-------N----EIK-KLC--DVESFVNEFQEFFKEKT-GFSPWSLQIVWAKRVALGRSFSLIAPTGIGKTTWGIVASAFL-E-------------G----RSYIVVPTKILVEQI---FERVS-------------------AI---TDK------------NVLAYT-G--------KK-REKEKIFQ-GEF-D------VLITTTNFLYRNYEK-I-P---SN-----FKFIFIDDVDSVLKS-GKNIDKILKVAGFSD--DAISTA-------LEVITLKS---KLA-----------SVKD------EKI-RER----LLKK-------I-----------AFLEKKLDS-LK--KR-VD--T-VL--VVSSAT--SSPKSK-RVKLFRELLDFEVGKVST-TLRNVEDVVV----LP-----------------EKDI-LEEGI------------NFIKKYG-K---GVFVFITEVWGKEF-------VNNVVDLLNSN-GIRAVSYENF--S----VENYDDFRKGKIEAVVGIASYKNPLARGIDIPDAVRYAVFLGVPGMKFLV-------DF-S--LAPQKLFSIILACREF-L----------DAEKV-VFYLNYLR-KYR---------------------------FMK-EEE-----VEK-------YPALKS-KLEEISTYLKEKFADSEFIKKLKES-DSV---FLT-QE-------DGN--LYL-IVGDAVGYIQASGRTSRMFAGGLTKGVSFLLV--DD--LKAFNSLRKRVS--ILYKD-MEF------KVFANKKGIDFANRKGLSLI------------DE------E-------SLKKIFAEVDKDRERVKRI-LK-G
>RLG04089.1 reverse gyrase [Thaumarchaeota archaeon]
-------------------------------------MD-----------------------------KAGIMVAR----------------------------------------------------------------------------------------AIYSFACINCGGEILD-ERLLKLGLCEKC-L-----SD---------------------VGDI-DLQQ----AIEILKSSGRL-------K----KLR-EIS--TLYTSYLEFKEFFKRAV-GFEPWALQEVWAKRILLGENFAIVAPTGIGKTVLGLVMALYL-AS-K--------G-K----RCYVIVPSSILAQQL---YEKAE-RF----AER-------A-GI---KSVE------------IIAYH-AGL--SRGEKE-EALKKISS-PRS--------LLITTDRFLVDRFEN-L-KG--N-----VFDYVFVDDVDSFLKS-PKNIDRAVSLLGFDP--EIVDQV-------LKLIELRR---RIA---R----G-------------FD--KD----LLKE-------Y-----------ERVERIVEREKR--KR--R--G-LL--VISGAP--LRGKRTKRLMIFRELLGFEVGRLPE-FVRNIEDLYI----EPKKSD----------------L-VDEAI------------SLVKKHG-P---GCLIFIPQALGKDF-------AAEVAERFERA-GIRVHLYEKM---E---ADILQRFCDGEIDAMVGIASLRSPLARGIDLPERIRYAIFIGVPRREMTI-------SK-DE-YNPTRILTLIYNIMPI-L-EKR------LKDEA-EAVAAKLS-KIVP---LNKE---LMERIR-E--------AVE-RGE-----RLE-GF----EGYAED-AIIAGREFLKKVLT-DELIERIRRE-LDI---SIK-PI-------EDG--FSL-IIPDASGYIQASGRTSRLYAYGVTKGMSIVLV--DD--PKAFKGLASRLK--VMLEE-LEF------E-----------------PY------------DG------R-------KAELVFKEIDSERKIIREL-KL-G
>O67226.2 RecName: Full=Reverse gyrase 2; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Aquifex aeolicus VF5]
--------------------------------------------------------------------------MAL---------------------------------------------------------------------------------------ELIERGCPNCGGVISS-DRLEKGLPCSKC-LPK------------------------------PTEEK----VCDALEELKTL-------K----YLK-PFC--DTDKSLERFINFFEKAV-GAKPWSLQRVWAKRVFMNQSFAIVAPTGVGKTTFGLVMSLFL-K-------------G----RVLAIFPTRLLAQQA---GDRLS-EL----AQK-------V-GV----NK------------KILIYQ-SK--------K-NIREQFLN-GDW-D------ILLGTNMFLHKNFEN-L-I---NF----KFKLIFIDDIDSFLKR-GKNVDYLFKLLGFSG--EEIKLA-------LK---------------------------------ENK-TQR----DYDR-------L-----------ARIRKR--K--------RD--T-VL--IVSSAT--LKPRGK-RAYLFRNLLGFDVQKAIT-TLRNIVDVAE----PVKD---------------LEEA-LEKSV------------ELIKKLG-K---GGLVYLSVFYGKDK-------VQEVKEFYRKH-GINAVSYLDY--KP---EELYQILEKGEFDVAVGISHITNPLVRGIDLPHIIRYAVFLDPPKHVFPT-------EL-T--LSPPLLHGLLLTLLNL-F-EGD------DRLKA-IQYVMYLK-RYL---------------------------TLR-EEQ-----LDN-------YPRIKE-RVEEIKNFLENYLKDENFLKKIKES-EDI---SLV-PK-------EGK--LYI-VVGDANSYIQASGRTSRFIAGGMTKGLSVVYY--SD--PKAFYSLKKRLALYYMTQE-IEF------K-----------------RL------------SE------V-------DLNKLIKEIDEDRKRAREI-LQ-G
>WP_010880728.1 reverse gyrase [Aquifex aeolicus]
-----------------------------------MFIKKKSK---------------------RFPSKSYPIIMAL---------------------------------------------------------------------------------------ELIERGCPNCGGVISS-DRLEKGLPCSKC-LPK------------------------------PTEEK----VCDALEELKTL-------K----YLK-PFC--DTDKSLERFINFFEKAV-GAKPWSLQRVWAKRVFMNQSFAIVAPTGVGKTTFGLVMSLFL-K-------------G----RVLAIFPTRLLAQQA---GDRLS-EL----AQK-------V-GV----NK------------KILIYQ-SK--------K-NIREQFLN-GDW-D------ILLGTNMFLHKNFEN-L-I---NF----KFKLIFIDDIDSFLKR-GKNVDYLFKLLGFSG--EEIKLA-------LK---------------------------------ENK-TQR----DYDR-------L-----------ARIRKR--K--------RD--T-VL--IVSSAT--LKPRGK-RAYLFRNLLGFDVQKAIT-TLRNIVDVAE----PVKD---------------LEEA-LEKSV------------ELIKKLG-K---GGLVYLSVFYGKDK-------VQEVKEFYRKH-GINAVSYLDY--KP---EELYQILEKGEFDVAVGISHITNPLVRGIDLPHIIRYAVFLDPPKHVFPT-------EL-T--LSPPLLHGLLLTLLNL-F-EGD------DRLKA-IQYVMYLK-RYL---------------------------TLR-EEQ-----LDN-------YPRIKE-RVEEIKNFLENYLKDENFLKKIKES-EDI---SLV-PK-------EGK--LYI-VVGDANSYIQASGRTSRFIAGGMTKGLSVVYY--SD--PKAFYSLKKRLALYYMTQE-IEF------K-----------------RL------------SE------V-------DLNKLIKEIDEDRKRAREI-LQ-G
>WP_068549606.1 reverse gyrase [Thermosulfidibacter takaii]
------------------------------------------------------------------------MKDSM---------------------------------------------------------------------------------------AYFDNLCPNCRGYVGD-NRLEEGLPCSKC-LPA-PH-----------------------------NEN----VCYDLFKRRTI-------K----FLK-DVC--YAEKLVGDFVDFFTSMV-GEKPWSLQVTWAKRVFLNRSFAIQAPTGIGKTTFGIVMAAFL-Q-------------G----RSYIILPTKLLVQQV---YERLS----------------------SLCDK------------RIVAYT-GK--------K-KEKKQIED-GDF-D------ILVTTQAFLQKNIDI-L-P---KD-----FRFIFVDDVDSVLKN-PKNVDNLFKLLGLTD--EDISRA-------LKL--------PL---------------------------------DSPK-------L-----------EYIRKKIR-------------G-IL--VVSSAT--LKPKTK-RVNLFRSLLGFDIQRSVS-SLREVEDLYI----EAEN---------------WEEA-KSKAL------------RLIEKLQ-R---GIFIFVPNEKGKAA-------VEELVQWLNKQ-GISAVSYEDF--D-----ENIEAFKKGDIRVAVGIAISNNALVRGIDLPYWVRAAVFMDVPKFIFPL-------RV-E--PDPSKLFTLLRLINTV-L-KDE---------KL-NQYLSYLK-KYS---------------------------TMT-KEN-----LDK-------YPSIKE-KVSKICEYLSGLLEREDIRRLLIEN-DNV---YLT-DI-------EGE--TYV-VVGDAVSYIQASGRTSRLIPGGITKGLSVVIV--VD--RKAFNSLAKRVR-YLLPQE-TQF------K-----------------KF-----------ENF------D-------ELDDIIKELDKSRNPS--------
>WP_121012168.1 reverse gyrase [Hydrogenivirga caldilitoris]
--------------------------------------------------------------------------MSL---------------------------------------------------------------------------------------LIIERGCPNCGGAISD-ERLSKGLPCSKC-LPK------------------------------P-EEE----VCEALEKLNKL-------R----ELK-PYC--ETDRRLGEFESFFERAV-GARPWSLQRLWAKRVLRKESFAIVAPTGVGKTTFGFVTSLFL-E-------------P----KALLIFPTKLLANQA---GERLR-EL----SQR-------L-GL----EK------------RILVYE-SK--------K-KVKEQFLS-GGF-D------ILCGTNMFLHRNFEN-L-M---NF----RFKFIFIDDIDSFLKR-SKNVDNLFKLLGFTD--YEIKLA-------LK---------------------------------ENK-TEK----DWDR-------L-----------SQIRKR--E--------RD--T-VL--IVSSAT--LKPKGN-RVFLFRNLLGFDVQKAVT-TVRNIVDVAE----PAKD---------------LEDA-LGRSA------------ELIKKLG-K---GGLVYLSVFYGKDK-------VEEVVEFYRKG-GIKAINYLDY--KA---EELYKTLEKGEFDVAMGISHITNPLVRGLDLPHVIRYAIFLDPPKHVFPT-------EL-T--LQPSLLHSMLLALLNL-F-EEE------DRLKA-IEYINYLK-RYL---------------------------TMR-DED-----LDK-------YPRIKE-RVQEIKDFLEGFLTDREFLKKIEES-EDI---SLV-HR-------DGQ--LFV-VVGDANSYIQASGRTSRFIAGGMTKGLSILFY--SD--PKAFRSLKRRLAAYFMQSD-VEF------K-----------------SL------------EE------I-------DLEKLIKEIDEDRGRARLI-LE-H
>WP_013866824.1 reverse gyrase [Methanothermococcus okinawensis]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------IIYKEMCPNCNGEITS-ERLEIGV-CERC-LKE-EKVF--------------------------EKLE----LCKKLREEHTL-------N----NLK-NYC--NTWKEFKEFNKFTKSL--GYELLSLQKMWAKRILKNKSFSIVAPTGVGKSFFGILISLFL-AK-K--------G-K----KCYIILPTTILVRQN---YEKIL-SL----IE--------N-KL---NIN-------------IIAYH-SEL--SAKEKK-KAKENIKN-NNY-D------LLITTSNFLVKNIP--------NT----AFDFIFVDDVDALLKA-SNNIDKTLKLLGFNE--DIINEA-------YDIIR-------LIK--------------------IGR-LND----ALKKR------------------KTLKNKISK--------IK-HG-CL--VIASAT--GKSYGR-KVKLYREILDFEIGFGMN-KLRDVIDAYD------------------------EEFSKEKIL------------EYIKLLG-K---GGIVYVSKDYGIEK-------AQEIEKFLLKK-GINAKLIHSKD------KKGFDEFKNGNIGVLIGMASYYGILVRGLDMPERVRYALFYGIPKFKIKL----------KE---------YIDDLKNKGKLKED------VDIEG-KT-------------------------------------------------------------------KEEIKQILIEKL-------KIKN----F---SLR-KDN-----NNNE--YNL-LIPDIKTYIQASGRTSRMTEFGLTKGVSIVLV--DE--KEIFEYLEKYML--FAY-E-SEF------T-----------------SI------------DN------I-------DIKELIKKIDKIRE---KI-KL-G
>PUA33833.1 reverse gyrase [Aigarchaeota archaeon NZ13_MG1]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------VIYEDLCIACKKDVSL-EEIFEA----RC-SVK-N-------------------------------------------------------V--------PFSSVVRSPEEVELEDLFRKTL-G-EPREIQRFWIKRFVRGESFTVVAPTGIGKTAFGLITSLFL-AS-K--------G-K----KSYIIVPTTILVEQC---VNELR-SF----CSK-------I-GR---NAGINEEGE-----VTIAFYH-ERI--DKKEKE-KFEGILKN-GNF-D------VLVTTAAFLSKRFDR-I-KD--M-----HFDFIFVDDVDAILKA-SKNVERVLYLLGFRN----------------------------------------------------V-DGE----WAGE------------------------------------PK--G-IL--MVSTAT--TS-KGK-ATRLFRKLLNFDVGSSFF-TVRNVEDFYL----NSEE--------------------PERIK------------EILRSMG-S---GCIIYARN---SEV-------AEKYYEALRDE--FSIGLVLAG--R----KDAYDLFCEGKVDHLIGTSYYYGLLVRGLDLPKKIRYVIFIGAPVLRIKSE------AL---------TPNLIKALALS-LQDEEP-----------------IR-RNLP----------LILSLE-R---------------------------------HPE-RLEEIRQLVSEVVRAKKA--------EDL---VI------------RE--GEI-IFPDIRTYIQGSGRSSRLTVNGLTKGASFLLE--KD--EEVLKAFIKRAK--YY--D-IAF------K-----------------HF------------SE------A-------DFGSLKKELDDSR-------ML--
>RLD13162.1 reverse gyrase, partial [Caldiserica bacterium]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------LYR--------DYTE-EALK--------------------------------------------------------------------------------------DEEEEFLLLFKKII-G-KPRWIQRFWIRRILNKESFSLVSPTGVGKTTFGLITSLFF-LK-R--------N-K----KSFVIVPTTLLLLQC---VENLK-NF----LKK-------L-GM---EDKINGEGR-----EVVVFYH-GRL--KKEEKE-RVRKGIKE-GNY-N------ILLTTTQFLTKNFNL-I-SD--K-----VFDFIFVDDVDSVLKR-SRNVDKILALMGFKK----------------------------------------------------K-GKE----WYGS------------------------------------TN--S-IL--VVSTAT--AK-KGK-STLLFRKLLNFDVGSSFS-TLRNIEDVLV----SNNG--------------------IETIE------------NILKLMG-D---GGIIYARS---LED-------VEKYYNLLKRK--FKIGIITST--K----KKDYERFKNGELDYLIGTTYYYGLLVRGLDIPQRIKYTVFIGAPVIKAIYE------HL---------TPKMIKMIFLS-AKKYKE-----------------LK-RY------------------------------------------------------PK-TPEELKNLIKEGEIKSDL--------EDI---IL------------TD--DGV-IFPDIRTYIQASGRASRLTLKGITKGASFLIE--SD--QRIARSFVKKAE--YF--D-IVF------N-----------------DI------------KD------V-------DFVKLKEEIERSR-------RE--
>RUM48008.1 reverse gyrase [Hyperthermus sp.]
--------------------------------------------------------------------------MR--QPCYNSLDEITEIGEGKRFSSTR----------RGEGAVE-----------VVL-------WKS--------------------LQPLYSGACPNCGGLIGA-DRLEKGIPCSRC-LPG-NYTG-LPG------------------DFYSLVEF----IGKKLAERGRL-------Q----GYS-LLY--STIKETRSFSSFFRKVV-GHDLWSAQLTWARRLLSNESLAIVAPTGVGKSTLLGVYSLYR-AL---------EG-A----KVYYLLPTENLVVQT---LSKLE-AM----SSR-------V-EA---V-------------PKIVGYY-SGL--SRRIRE-SVLEDIAN-GSY-N------ILVTTTSFLSRRWSI-L-GD--KF-----FNVIIVDDVDAVLRN-SKNIDKLLQLLGFNE--EVLQLA-------MRLIKAKM---KLLI-AKVSGN-------------MRK-YLR----LLEE-------I-----------EEVESTMASKLAN----VT-PG-QL--VIASAT--GRVRGI-KPKLFRELLGFEIGRVYD-YTRSVANFYL----ASSRET-L----------------LRDTI------------RVTVELG-S---GGLVFVARRYGRNL-------ARLLVEELNKN-GIRAGLAISG-------SRVLDKFEAGDYDVLVGMASYYGVIVRGLDMPHRVVYTVFVGAPSMSLEADK-----IL----TSPFTIARLAMEMG--------------------IEGNENIV-KVV--SKLAPG---EQTALR---------IALA-NKQ-----KLE-GRLEEVRSMLDW-ARRTITRRLYAKLCADGGMGQLILG-G-L---LF--KC------VDGI--VVA-IVPDPATYVQASGRSSRMLGSYMTHGVSIIVE--EE--PLLIELLKRKLT--RFIEE----------L-----------------EF------------IE------F-------DERKVALELSRARKSREM-----G
>RLE59131.1 reverse gyrase [Thermoprotei archaeon]
-------------------------------------------------------------------------MPY----------------------------------------------------------------------------------------AKFKNLCPLCGGVIDS-DRLEMGLVCKKC-SAK-LSRR---EK-SIQA------------------------------------------S----TLN-RMLLREIESDFRELNLFFEKSI-GASMWSAQRMWAKRILSGRSFSMIAPTGSGKTVFGILISLFL-AR-R--------G-N----KVLFILPTSILVEQV---YEKMK-IF----NDK-------L-GL--G-VN-------------IISYH-TFL--TKKEKD-RIKDDISL-KEY-D------VLIISSSFLARQYDI-L-GI--R-----RYDLIFIDDVDSILKS-SKLFDKILYLLGFNE--EIVNYG-------LKVLQLK-----------RKGLR-------------KG-DFS----LLEE-------I-----------EKLQEKIAEYKK--NN--K-IG-TL--IVSGAS--LKGRRTKRVKLFMELLDFDVGAKVE-GLRNIVDVYT----FSED------------------I-LQDTL------------YYVKSLG-K---GGIVFVSQDKGLSF-------VKEIYDFLTSH-GIRAEAYIRP---K---RGILKRFREGEVDVLVGIASSRSPLSRGIDLPEVIKYAIFAGVPKIDFSL-------DP-KD-LSPAKKIVFLATISEY-L-SKR------ERNIC-RRYMGRLR-NVLSVATLYYR---NPEAVQ-G--------DIK-E-------------------YLAS-LLKEIDNFINKKMENKTFLKKLSKS-PFV---EVL-EE-------EKI--LKL-VISDPVAYIQGSGRTSRLYAGGVSKGLSILLV--DD--EKAFHHLQREVS--RRISD-IDF------K-----------------RI------------ED------I-------RLDEVLKEINIEREIIRSL-LE-G
>WP_010880537.1 Reverse gyrase 1 [Aquifex aeolicus]
--------------------------------------------------------------------------MIK---------------------------------------------------------------------------------------AIFDTLCPNCGGEISA-ERLLKGLPCEKC-LPE-E---------------------------VN-REE----VC------QKL-------E--NGSFK-EFC--ELLSELKDWEDFFKEIL-GTSPWSLQKSWARKVFLGRSFAMLAPTGVGKTTFGLSMASYL-A--K-------QG-K----KSYIILPTQLLVEQV---SERIK---------T-------F-GV---DED------------RLIVWG-KL---SEKKKK-ELKERIQK-GDF-D------ILITTSMFLYKNYEI-L-P---KD-----FSFIFVDDVDSFLKT-AKNVDKVLYLLGFSE--EDIHKA-------FELIRLK--------------------EK------PNK-SEE----DWEE-------I-----------KKRSEELRE-IA--KK-KK--G-VL--AVSSAT--GNPRSN-RIKLFRELLGFEVGKPSV-LLRNIVETYE----ET------------------QNL-KETLL------------KRVKEFG-K---GGLVFVSSDYGREA-------VEEVKKFLESH-GVKAVTYEE----------DLKLFEKGEAQVAIGISSFKNPLARGIDLPHVVRYAIFYGVPKIRVPL-------KV-E--TSVSHLLWALLSLRPI-I-LKDEKLKS-EVKKV-DTWIQRLR-RYS---------------------------FLS-DDF-----VEE-------RPDLKD-RIENLRKEVQEFLLREDIVEKIKNS-EEL---TLR-LG-------EEG--FEL-VVADVTGYLQASGRTSRMYAGGLTKGLSHVLV--DD--RRAFKNLEKKVR--WFNQD-INF------K-----------------KI------------EE------V-------DLKEVLREIDEDRKKVREI-LE-G
>RKX47948.1 reverse gyrase, partial [Thermotoga sp.]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEGMV-KR----IDGD--------------VD-------------IIHYH-AGM--KEKEKK-EFFEKLER-GDF-H------IAIFSTQFLSKNREI-L-SK--L-----KFDFVFVDDVDAVLKS-SKNIDTILMMLGIEK--EAIEKA-------LMKLRK------------------------------------------KRE------------------EEFEIG--------EH-----G-IL--VVSSAT--ARPKGI-RPLLFRELLGFDVGTLVV-GVRNITNLRV----KSED--------------------TDDLL------------DLLEKLK-D---GIVLLARDEKTIKW-------LSEI---VEGA-GFPVGKSWEN---L---EKALEDFSEGKVSIIAGVYSYYGKLVRGLDLPKRVKFVIFWGTPVFEYFI-------DM-EK--------------------APKFV----------------IR-RVLF-----------------E--------VSK-KNT-----RVK-KL---LQIVDRS-DIETLRNRLKVVLTEDEWEETIKRIFARY---RIK-ER-------------KL-LLPDVLTYIQASGRSSRLLGSKLTKGVSILFE--TD--DAVFESLKERLD--WLTEE--EW------I-----------------DL------------ED------A-------DWETLLKEVEESRKEEK------K
>RLI29443.1 reverse gyrase [Candidatus Bathyarchaeota archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------ALYLNVCPNCGRGEED-QRLLKGLPCPVC-FPY-EV-------------------------------E----PCS-LP--EKL-------Q----KLR-KHC--HFREKVKEFERFFEERF-GSKPWNLQVYWAKRLILGRSFSILAPTGIGKTTFGAVAALFL-G-------------G----RTYIMLPTSILVVQV---ERLLK-------------------RL---GAR------------NVVAYH-ADL--SSREKK-EAKERIAK-GDF-K------ILVATSMFLSKNFSL-L-EG--KT-----FDFIFVDDVDSLLKK-AKNVDKVLMLLGFTR--EEIDEA-------LKAVEKPG---QPV-----------KV-----------------------------------------------------K--RK-RR--G-LL--VVSSAT--AKPKTK-RVKLFRYLLGFEVGMPIG-GIRNVEDVAV----FP----------------AEENV-VEAAV------------SLVKRFG-G---GALVFIPSDMGREK-------IGEVVEALRKA-GVEAESYEKL--D----EKLIEKFTKGEIQALVGISSAKNPLARGLDLPQTIRYAVFAGVPKNRILL-------DF-SS-MTIPQCFAVMIAVKAF-L----------EPNQA-NRYLWELK-RYL---------------------------TVD-PE--------K-------NEKARL-LLEEVRRFLAEALMKPEVLKRIEES-PNL---WLD-RT-------PEG--FAL-LIADAAGYLQASGRTSRLFAGGISRGASFLVV--DN--VKAFNDLKRRLS--WFLDE-AEF------K-----------------PV------------EK------V-------DLNRLFEEIDRDRRKIGEL-RA-G
>WP_076712106.1 reverse gyrase [Desulfurobacterium indicum]
--------------------------------------------------------------------------MKT---------------------------------------------------------------------------------------AIFRNLCPNCRGDEGS-DRLDKGLPCEKC-LPE-FD-----------------------CS-MS-QKD----ICKILK--ERR-------K--LSHYK-NIC--DVIGFVNEFSQFFREKT-GFIPWSLQLTWAKRVALKRSFSLIAPTGIGKTTWGMVTSSFL-K-------------G----KSYIVVPTRILVQQV---YEKLT-------------------KL---TDR------------EVLAYT-G--------KK-SEKERIFS-GDF-E------ILVTTTNFLYKNWNK-I-P---VD-----FEFIFVDDVDSVLKS-GRNIDKILKLVGFDD--DALSIA-------IEIIDIKQ---KLA-----------KVSS------EKS-KQF----FLKR-------L-----------NYLEKKLTV-FK--QN-IK--T-VL--VVSSAT--AAPRSK-KIKLFRELLDFEVGKTGT-SLRNVEDVAV----FP-----------------EKGL-LEESL------------GLIKMFG-R---GVFVFVSEAYGKDY-------VDKVVSFLNSK-GIVSVSYEDF--S----VDKFDEFRKGQIEAVVGIASYRNPLARGIDIPDAVRYVVFIGVPRMKFPF-------EV-S--LSPSRLFTFILVCREF-L----------EQDKV-AAYLPFLR-RYL---------------------------TLT-EDK-----LDS-------YPPVKE-KIEEIARYLRENLSDESFIDKIKKS-DSV---FLE-EE-------NGK--FFI-VVGDSTGYIQASGRASRMFAGGLTKGVSFLLV--DN--LKAFNSLRKRLL--LYLED-INF------KVFDNELGREVARKKGFEII------------TI------D-------ELDEIFKQVDKDRERVKAI-FE-G
>WP_055409889.1 reverse gyrase [Pyrodictium delaneyi]
--------------------------------------------------------------------------MT---------------------------------------------------------------WTL--------------------LRPVYHGACPNCGGPAAA-DRLSRGLPCSQC-ISD-DELSGLPS------------------SYYELVEF----IGRKLSEKNRL-------R----GYW-YLY--SSVATLKEFESFFQKAT-GSSLWSAQRTWAKRLLQDESLAIVAPTGVGKTTLLSTYALYR-AS---------HG-A----RVYYLLPTENLAMQI---ENKLK-RL----AAA-------S-GV---E-------------ARIVSYY-SGL--SKQRRE-ESLSAIEA-GNY-D------VLVTTTGFLSRRWDM-L-ES--TR-----FDVVLVDDVDAILRN-SKNIDKLLMLLGFDE--EAIAIA-------YTLLKKKI---AASI-AKVSGH-------------IKR-YEQ----LLHE-------I-----------EDLETKLSLKLLE----KT-PG-QL--VIASAT--GRAYGL-KPKLFRELLGFDIGRVYD-YTRSIANFYL----VDGNP-------------------VEKIV------------DIVQRMG-P---GGLVFVAKRYGKDV-------ARQIAERLNQA-GIRAGLALAG-------RRVLDRFAMGEYDILVGVASYYGVIVRGIDMPHRILYTLFVGVPSQAMSADK-----AL----LSPFRIVRAAVELG--------------------IEGSEELA-RKL--SKTSPG---EQTALR---------IALS-SGE-----QLE-GRLAELLSELTE-ARRKVLRRLYEVLEPG---SSLVVG-G-I---LY--KH------DGSE--IIA-IMPDAATYVQASGRASRMLGSIMTHGVSIIIE--SE--EELIKLLSQRLR--RYLDN----------V-----------------EF------------NK------L-------DWNHVEEELEKARISRSK-----R
>WP_013775510.1 reverse gyrase [Acidianus hospitalis]
----------------------------------------------------------------------------M------------------------------------SEELPN---------------------------------------------LVYMNSCPNCGGEITA-NRLYKGSACEKC-VKE-DIQFNSVYD-----------------------------LALYLLKNKNL-------V----NLR-SSY--EILKELKEVERLFKRVL-GSPPLGPQRSWIVRALRGESFAIIAPPGLGKTTFGILMSLYF-AE-K--------Q-R----KTLMIFPTKTLVNQV---VQRIQ-EM----SKS-------L-EE---------------V-PKLAYYY-SGI--TQSQKG-ELNKILES-GDF-D------IFISTSRYIINNVDY-I-STK-------DYKYLFVDDVDSVLKS-SKSASAVLKLVGFTE--DDIQNV-------RELLRKSK---N-------------------------S--EE----VYDE-------I-----------RKIREKKTG-----DK-------IA--IFSSAT--IT-KGN---PVFSALMGFRPGSAVI-YLRNVIDSYVQ---LPSA--------------TDEEI-IDIVN------------KIVNKLG-S---GGLIFVPIDKGVSF-------ANEIASNISG---LKAEAISSTS------ITKLDKFEKGEIDVLVGVATHYGILVRGIDIPWRIRYAIFAGIPRFRFKIG---------ET-MHPLAMLKMLTLISLV-S----------KDEEV-TKILRIVR-NKL--RRISPA---ALVMLA-N--------SVK-SGK-----IE------------DK-YIQEAYDLTNKYLRNEEILEKIAEI-GEI---SI-----------NNR---YI-SSPDYLTYIQASGRTSRIFGGELTTGLSVLLV--DN--PRLFELLNRRLS--IVLDE-VSW------N-----------------PF--------DIDNNK------IGN----NNLHEILKRIDSEREKIRKI-KKEG
>WP_088171896.1 reverse gyrase [Pyrodictium delaneyi]
--------------------------------------------------------------------------MT---------------------------------------------------------------WTL--------------------LRPVYHGACPNCGGPAAA-DRLSRGLPCSQC-ISD-DELSGLPS------------------SYYELVEF----IGRKLSEKNRL-------R----GYW-YLY--SSVATLKEFESFFQKAT-GSSLWSAQRTWAKRLLQDESLAIVAPTGVGKTTLLSTYALYR-AS---------HG-A----RVYYLLPTENLAMQI---ENKLK-RL----AAA-------S-GV---E-------------ARIVSYY-SGL--SKKRRE-ESLSAIEA-GNY-D------VLVTTTGFLSRRWDM-L-ES--TR-----FDVVLVDDVDAILRN-SKNIDKLLMLLGFDE--EAIAIA-------YTLLKKKI---AASI-AKVSGH-------------IKR-YEQ----LLHE-------I-----------EDLETKLSLKLLE----KT-PG-QL--VIASAT--GRAYGL-KPKLFRELLGFDIGRVYD-YTRSIANFYL----VDGNP-------------------VEKIV------------DIVQRMG-P---GGLVFVAKRYGKDV-------ARQIAERLNQA-GIRAGLALAG-------RRVLDRFAMGEYDILVGVASYYGVIVRGIDMPHRILYTLFVGVPSQAMSADK-----AL----LSPFRIVRAAVELG--------------------IEGSEELA-RKL--SKTSPG---EQTALR---------IALS-SGE-----QLE-GRLAELLSELTE-ARRKVLRRLYEVLEPG---SSLVVG-G-I---LY--KH------DGSE--IIA-IMPDAATYVQASGRASRMLGSIMTHGVSIIIE--SE--EELIKLLSQRLR--RYLDN----------V-----------------EF------------NK------L-------DWNHVEEELEKARISRSK-----R
>RLI35445.1 reverse gyrase [Candidatus Bathyarchaeota archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------ALYLNVCPNCGRGEED-QRLLKGLPCPVC-FPY-EV-------------------------------E----PCS-LP--EKL-------Q----KLR-KHC--HFREKVKEFERFFEERF-GSKPWNLQVYWAKRLILGRSFSILAPTGIGKTTFGAVAALFL-G-------------G----RTYIMLPTSILVVQV---ERLLK-------------------RL---GAR------------NVVAYH-ADL--SSREKK-EAKERIAK-GDF-K------ILVATSMFLSKNFSL-L-EG--KT-----FDFIFVDDVDSLLKK-AKNVDKVLMLLGFTR--EEIDEA-------LKAVEKPG---QPV-----------KV-----------------------------------------------------K--RK-RR--G-LL--VVSSAT--AKPKTR-RVKLFRYLLGFEVGMPIG-GIRNVEDVAV----FP----------------AEENV-VEAAV------------SLVKRFG-G---GALVFIPSDMGREK-------IGEVVEALRKA-GVEAESYEKL--D----EKLIEKFTKGEIQALVGISSAKNPLARGLDLPQTIRYAVFAGVPKNRILL-------DF-SS-MTIPQCFAVMIAVKAF-L----------EPNQA-NRYLWELK-RYL---------------------------TVD-PE--------K-------NEKARL-LLEEVRRFLSEALMKPEVLKRIEES-PNL---WLD-RT-------PEG--FAL-LIADAAGYLQASGRTSRLFAGGISRGASFLVV--DN--VKAFNDLKRRLS--WFLDE-AEF------K-----------------PV------------EK------V-------DLNRLFEEIDRDRRKIGEL-RA-G
>WP_083494477.1 reverse gyrase [Pyrodictium occultum]
--------------------------------------------------------------------------ME---------------------------------------------------------------WTL--------------------LRPLYHGACPNCGGPITA-DRLSQRLPCARC-MPA-APES-LPH------------------DYYGLVER----IGRELASRGVL-------Q----GYL-YLY--STVTMLRDFEEFFHRLT-GGRLWSAQRTWAKRLLQNESMAIVAPTGVGKTTLLSVYALYR-AR---------SG-A----RAYYLLPTENLARQV---EEKLR-VL----AER-------G-GV---A-------------ARIVSYY-SSL--SRSRRE-ESLHLIER-GDY-D------ILVTTTGFLSRRWEL-L-QG--TR-----FDLVLVDDVDAVLRN-SKNIDKILMLLGFDE--ETLATA-------YSLVKKKI---LASL-AKLSGN-------------IRR-YEQ----LLRE-------M-----------EELQARLSAKLVT----ST-PG-QL--VIASAT--GRAQGL-KPRLFRELLGFDIGRVYD-YTRSIANFYH----VSSDP-------------------AGDAV------------EAVRRLG-P---GGLVFVAKRFGKDL-------ARRLVKALNEA-GVRAGLALAG-------RRVLDRFASGEYDVLVGISSYYGVIVRGIDMPRRVLYTVFVGVPSQAVSAEK-----AL----QSPFRIVRAGVELG--------------------IEGSEETA-RLL--SRTSPG---EQTALR---------IALA-SGE-----KLD-GRLGELLEGLQA-LRRRVLARLQETLEPG---SSTVVG-G-V---LY--RH------TGSD--IVA-ITPDAATYLQASGRASRMLGSIMTHGVSIVFE--EE--EELVKLLSQRLR--RYLES----------V-----------------DF------------EK------L-------DWRKVEEEMEKARASRSS-----G
>WP_020962324.1 MULTISPECIES: reverse gyrase [Thermofilum]
--------------------------------------------------------------------MHDYE-LG----------------------------------------------------------------------------------------AVYKSMCPNCGGDISD-HRLASKTPCRVC-LPE-DKLS-ELKNTATGKKHRGK----NVDDFLAHLEQ----VIRLLEAQGTK-------K----ELE-KFY--NVEKKLLEFGEFFSQAL-GSRPWSAQRTWARRVFLGKSFVILAPTGVGKTVFGILTALFL-SK-E--------K-R----KSYLILPTSALASQV---YEKAR-AF----ASK-------L-GL--DPES-------------IVIYH-GSL--SKNHKE-EVIEKIRS-GGY-S------VLITTSQFLARNFDK-L-EG--Q-----KFDFVFVDDVDSIIKS-SKNIDKLLVLLGFSR--EDIDLA-------LRTIRETS---RLT---RLLRNG-------------NV-SDE----DRLQ-------V-----------EKLREKLRENLS--K-S-E-HG-VL--VVSTAT--GRPRGT-RIRLFRELLGFEIGARGE-FLRNIVDTYT----IV-ANK---------------DI-VEKAV------------ELVSELG-G---GGLVFVPIGTQEDF-------VLRLAGEFEKS-GIRAKVLYGKH-KD---KNAIKEFEAGNVDVLIGTASYYGTLVRGLDLPHVVKYVLFVGVPHFKFSL-------DL-GD-ITPLRLVQIASNVRNI-A-TKE------DQASL-DRLILYLR-EAL--QNMEPG---EYMAFT-N--------CIK-DNS-----CTG------KLARVAE-RIDLLKRIVGKYLSSLEYLDRLSKE-TSL---MIV-KD-------GET--LKL-LLPDVMTYIQASGRASRLYARGVSKGLSIVIC--ND--EMFFEKFKKFTS--FY--E-IEW------K-----------------PL------------EE------I-------NLEQLMREISHERQVIREI-ME-G
>WP_109160670.1 reverse gyrase [Desulfurococcaceae archaeon AG1]
--------------------------------------------------------------------------MLVSAVELVTRE----------------------IAEKLLG--------------------------------------------YRVPPAVYRWACPNCGFSESS-DRLALGIPCRRC-IDD-K----DLML----------------TERLEIKDL-HMKIYGALVRSGKL------RK-SDLGYE-ELI--RIEESVKEFSEIFRKCI-GRDPWSVQIMWAKRIFRGSSFSLVAPTGVGKTTFGIIMAIYL-AY-K-------QG-----LRSILIVPTIPLASQV---FKKAT-EY----ARK-------L-SL--DEEK-------------IIIYH-SKI--SPSKRK-ETLNKLSE-GDF-N------IFITTSAFFRNKENVKLLAG--------KFNFFFVDDVDAILKG-GKILYQVFEAMGIGE--DIIRKA-------EEIVSLKT---RLA---------------------LRE-NTE----DLLR-------I-----------RELKRSIEASKKS-HV-------IL--IISSAT--GRARGR-GIRVLREIFGFEIGSRYD-VIRNVVDTYS----IVKSRI---------------DM-VKEAS------------EIIKKIG-S---GGIVYVPKDLGVEY-------AEKVAHELSKRTGLRVLPLTSKN------VKVIDKFARREIDVIVGVSTYYGVAVRGIDLPDIIKYAIFLETPRHRIPL-------DL-EQ-MDLFDISRILELSLDV-V----------DPSKK-DEILGILN-KIL--RIIRRS---SSSYLR-E--------VFE-KVM-----RGS------VESNTEK-IIKSAIDTVNMLLADKNFVSKLKKN-PYV---RVS-KH-------GSK--IYV-DIPDWATYIQASGRTSRLYVGGISKGLSIIFE--KD--HRLLKGLERRLR--LFSEE-FVL------R-----------------EL------------RS------I-------DLDEVIREIERDRNNIVKA-RE-G
>WP_013537659.1 reverse gyrase [Thermovibrio ammonificans]
--------------------------------------------------------------------------MKV---------------------------------------------------------------------------------------AEFHRMCPNCGRIISD-KRLKAGLPCERC-LPE-FL-----------------------KW-KE-REE----ICEAI---EEL-------Q----NFQ-QIC--RLDRFVKEFTEFFKEKT-GFTPWSLQIMWAKRVALKKSFTMIAPTGVGKTTWGLVTSAFV-K-------------G----KVYVLVPTKLLVLQT---VERLK-------------------KL---TDK------------KVVAYT-G--------KK-REKETIAS-GEF-E------ILVTTTNFLYRNFEI-I-P---KP-----FDFVFVDDVDSLLKS-AKNVDKVIMLLGFTE--EDVELA-------MKVIDLKA---KAA-----------KS-S------GRE-LQK----LLER-------I-----------KRLEKHLER-RR--EE-ID--R-VL--VVSSAT--SQPRSK-RVKLFRELLGFEVGKSAT-ALRNVEDVLI----FT-----------------EKDE-LQLAV------------ETVKKFG-K---GVFLFVSADRGREY-------VDRVVETLNSN-GIPAVSYEEF--T----PENQQRFVNGEIWAAVGISSYRNPLARGIDLPQAVRYALFLGVPKMEFGV-------KL-S--LSPVKLFGLLLVLREL-F-SEE------ELPKV-NGYISYLK-RYL---------------------------TLK-EEL-----LDR-------YPKIKS-RLQEIKEFLEAHLSNPEFLKKIRES-ETV---SLK-EK-------NGE--LVL-VVGDAAGYVQASGRTSRMFAGGLTKGVSLMVV--DD--VKALNSLRKRVM--LFLED-VEF------KVLETDKGKEFAGKLGLPTI------------TE------E-------ELKAVFKQVDRDRKRVREI-LE-G
>KSW11918.1 hypothetical protein CF15_03740 [Pyrodictium occultum]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------MYHGACPNCGGPITA-DRLSQRLPCARC-MPA-APES-LPH------------------DYYGLVER----IGRELASRGVL-------Q----GYL-YLY--STVTMLRDFEEFFHRLT-GGRLWSAQRTWAKRLLQNESMAIVAPTGVGKTTLLSVYALYR-AR---------SG-A----RAYYLLPTENLARQV---EEKLR-VL----AER-------G-GV---A-------------ARIVSYY-SSL--SRSRRE-ESLHLIER-GDY-D------ILVTTTGFLSRRWEL-L-QG--TR-----FDLVLVDDVDAVLRN-SKNIDKILMLLGFDE--ETLATA-------YSLVKKKI---LASL-AKLSGN-------------IRR-YEQ----LLRE-------M-----------EELQARLSAKLVT----ST-PG-QL--VIASAT--GRAQGL-KPRLFRELLGFDIGRVYD-YTRSIANFYH----VSSDP-------------------AGDAV------------EAVRRLG-P---GGLVFVAKRFGKDL-------ARRLVKALNEA-GVRAGLALAG-------RRVLDRFASGEYDVLVGISSYYGVIVRGIDMPRRVLYTVFVGVPSQAVSAEK-----AL----QSPFRIVRAGVELG--------------------IEGSEETA-RLL--SRTSPG---EQTALR---------IALA-SGE-----KLD-GRLGELLEGLQA-LRRRVLARLQETLEPG---SSTVVG-G-V---LY--RH------TGSD--IVA-ITPDAATYLQASGRASRMLGSIMTHGVSIVFE--EE--EELVKLLSQRLR--RYLES----------V-----------------DF------------EK------L-------DWRKVEEEMEKARASRSS-----G
>WP_012582441.1 reverse gyrase [Dictyoglomus turgidum]
--------------------------------------------------------------------------MIE---------------------------------------------------------------------------------------AIFKNLCPNCGGDIAS-ERLLAGLLCEKC-LPK-E---------------------------VP-QEV----LC------NHI-------K--EEDY--DLC--SLKKKYGEWERVFKSFV-GFEPWELQKFWAKKLLLGRSFALLAPTGIGKTSWGLATSLYF-A--K-------KN-K----KSYIILPTKLLILQS---YEKLK-----------------D-KI---REE------------DLLVFGLDD---TKKEKE-EKRERLEK-GDF-K------VLITSSMFLYKNVDI-I-P---KD-----FGFVFVDDVDSFLKT-AKNIDKALYLLGFSE--EDINLT-------MSYIRMR----------------------------KNG---E------EE-------V-----------KRMQEEVRK-IA--KK-AK--G-VM--VVSSAT--SNPKSE-RIRLFKELLAFDVGRPVF-YLRNVEDIYE----EV------------------EDL-NKTLV------------ERVKRLG-K---GGLVFLSSDFGKEY-------VDEVKNLLINE-GISAESYDNL--T----PEVLEKYQKGEIFVLIGISSYRNPLARGLDLPEVIRYAIFYGVPKIVVNL-------DL-E--GNVRHLLIALASIRPL-V-ARDKNLEK-HVANL-DRWMKTLK-RYS---------------------------SML-----------N-------PP--RD-KVEELRNIIKAFILSPEVYEKIKSA-DDI---AIR-EE-------NGK--WVL-VVSDITGYLQASGRTSRLYVGGISKGLSYILV--ED--KKVFNNLVRKSR-WWFSTD-IIF------K-----------------ES------------NT------V-------NLDEILKQIDEDREKIRK------
>PNV79167.1 reverse gyrase [Dictyoglomus turgidum]
--------------------------------------------------------------------------MIE---------------------------------------------------------------------------------------AIFKNLCPNCGGDIAS-ERLLAGLLCEKC-LPK-E---------------------------VP-QEV----LC------NHI-------K--EEDY--DLC--SLKKKYGEWERVFKSFV-GFEPWELQKFWAKKLLLGRSFALLAPTGIGKTSWGLATSLYF-A--K-------KN-K----KSYIILPTRLLILQS---YEKLK-----------------D-KI---REE------------DLLVFGLDD---TKKEKE-EKRERLEK-GDF-K------VLITSSMFLYKNVDI-I-P---KD-----FGFVFVDDVDSFLKT-AKNIDKALYLLGFSE--EDINLT-------MSYIRMR----------------------------KNG---E------EE-------V-----------KRMQEEVRK-IA--KK-AK--G-VM--VVSSAT--SNPKSE-RIRLFKELLAFDVGRPVF-YLRNVEDIYE----EV------------------EDL-NKTLV------------ERVKRLG-K---GGLVFLSSDFGKEY-------VDEVKNLLINE-GISAESYDNL--T----PEVLEKYQKGEIFVLIGISSYRNPLARGLDLPEVIRYAIFYGVPKIVVNL-------DL-E--GNVRHLLIALASIRPL-V-ARDKNLEK-HVANL-DRWMKTLK-RYS---------------------------SML-----------N-------PP--RD-KVEELRNIIKAFILSPEVYEKIKSA-DDI---AIR-EE-------NGK--WVL-VVSDITGYLQASGRTSRLYVGGISKGLSYILV--ED--KKVFNNLVRKSR-WWFSTD-IIF------K-----------------ES------------NT------V-------NLDEILKQIDEDREKIRK------
>PDM25985.1 reverse gyrase [Candidatus Bathyarchaeota archaeon B24-2]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------VIYENLCSVCGRDLTH-EEIERE----VC-NTR-N-------------------------------------------------------L--------HLSYSPYNVQDREFEELFRKVV-G-EPRELQRFWMRRLVRRESFAAVAPTGIGKTTFGIVSALFF-AL-N--------G-K----KSYILVPTTLLVQQC---VENLT-NY----AEK-------V-GK---TIGLNEDGE-----ITVCFYH-SGI--KKDDKE-RFQELLER-GRF-D------VLVTTTQFLSKRFND-L-KG--R-----VFHFVFVDDVDAILKT-SRNIDRVLSLLGFEK----------------------------------------------------T-REG----WSGD------------------------------------AK--G-IL--MVSTAT--AK-RGR-STEVFRKLLNFDVGSSFF-TIRNVVDVAV----NTES--------------------LDEIK------------NVLRRMG-R---GCVIYART---VEE-------AERYYELLKEE--FKIGLVVSR--R----KSDYELFERGELDHLIGTAYFYGTLVRGLDLPEKIRHAVFIGAPLLRFRYE------EL---------TPKTVKTLALA-FRRNEE-----------------VR-KYLH----------LIPNLE-R---------------------------------HPR-ELEELKKVLRRVSETEKV--------EDL---VV------------RK--GEI-LFPDVRTYIQGSGRTSRLTVNGLTKGASFLFE--AD--EQILKAFMKRAG--YY--D-LSF------K-----------------SI------------GE------V-------DFQSLVRELEESR-------KA--
>WP_075049321.1 reverse gyrase [Ignicoccus islandicus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRDGCPVCGGAISS-DRLAKGLPCERC-L------------------------------PEEVPRD----RLKEMNLGGPL----G-----------QYF--KIEKEVEEAERVFHEVT-KSVFWSAQRAWLIRALRGESFSIVAPTGMGKSTFGALVSVLF-A--K--------K-F---GKSYVILPTTPLVEMM---YKKAK-PF----ADI-------L-GV------------------EVVKIH-SKM--SKGERK-EALEKFEK-GEF-G------VLITTSRFMINKLDE-L-TK--F-----KFSLIFVDDVDSVLKS-NKNVDRILQLLGLNE--EDLKEL-------WNIVNKEK---RIM---RYLLNT----ND------PEK-RLS----FLEE-------L-----------EEIEERVKELRM------K-VNGIL--IFSSAT--GKVRTN-RIAMVRKLLNFEPGGTSE-GVRNVIDSYTR---------------------------EG-FV------------KVVKALG-K---GGLVFVPADKGLSF-------AEEVARKLKEN-GVSAEVVSSE---R---VNVIEAFERGEVSVLVGVATHYGVLTRGIDLPHVIRYAVFVGVPRLKFKL-------KM-DE-PVPRAIVNVLRIAVEVGF------------EEY-AKIYKELA-KRY--RSLTQQ---AVEMLK-E--------RLM-NGI--------------VETDLEK-LFMKGFEIIRNLASKPEFVERVRRS-GFY---EIV-EE-------GGE--LYL-LVPDSATYLQASGRTSRLYAGGVTKGLSVVIV--DS--EHLFNGLKKRLR--WVIEN---W------Y-----------------PF------------EQ------L-------DLGELLKEIDEDRRKVLKV-LR-G
>RDD53262.1 reverse gyrase [Candidatus Korarchaeota archaeon NZ13-K]
------------------------------------------------------------------------MAMIP---------------------------------------------------------------------------------------AVFLELCPP-SGELRT-HERK------IC-I-E-E-------------------------------------------------------D--------LKR---ISSELEGFKRFFESCL-GSPPWEVQLMWAKRALARRSFAAIAPTGVGKTVFGLITSLYF-SY-R--------GWG----KSYLILPTSLLVDQV---HSNLL-RY----ISS-------S-GI---D-------------LKVLPYR-SRM--NGRERS-EFLSSLES-GDF-D------VLVTTSQYLSVNHEL-L-RRSVD-----RFSLIFVDDVDSFLKN-SRNVDKVLQLMGFSE--EDIRRA-------S----------------------------------HGE---E----VRGE------------------------------------VD--S-VL--IVSTAT--GK-PGK-RVALFRSLLGFDVGVVRPELLRNVADLFT----SNR----------------------DDLG------------EFARRMG-G---GFLLFVPS---MSL-------ADEAMELMESV-GFRGEVVHGY--E----EGKVREFSEGRLDFLVGAAKPYGVLVRGVDLPKRIRYVIFYGAPRFELTLG------EV-EG-IEEPFLSSLFLTLSRA-MGEDAR----------------RLA-MRIR----------R------NP--------------------------------REE-DLRRARQMIEELFSDEERLRSVSSA-ADV---VV--E---------AG---KI-MIPDIRTYIQGSGRTSRLFPGGITRGASLLWD--DE---PMLTAFIKRAR--AQ--E-LDP------L-----------------PL------------NE------V-------DLEGLRREIDESRRMLSSM-RS--
>WP_013908056.1 reverse gyrase [Thermodesulfatator indicus]
---------------------------------------------------------------------------ML---------------------------------------------------------------------------------------FLVAHACPNCGGTISD-ERLNRGLPCSKC-LPV------------------------------PTEQD----VCQALEEKGQL-------K----RLS-LFC--NALSELDKFRHYFQKAV-GFWPSSLQETWIKRLLLRESFAILAPTGTGKTTFGLLTSLYF-A-------------G----KVLILVPTRLLAQQI---GERLE-EF----SQK-------T-GI----KR------------QILAYL-GK--------K-KDKETFAS-QNF-D------ILVCTTAFFYKHLDE-L-L---DL----DFEFVFIDDVDSFLKR-SAHIDKLFKLLGFSE--REIALA-------LK---------------------------------PQK-TEK----DFEK-------L-----------EAIRKRH-A--------GK--K-IL--LMSSAT--LRPRTT-RVLLFRYLLGFEVQRAVS-SLRNVVDAYK----DMSSSD-------------LAGL-LQKAA------------ELVKILG-P---GGLLFLSQSYGKDQ-------VENVVEFLRAK-GFKVLSYLEL--SP---KEIMAQMETGDFDVAVGLAHLANPLVRGIDLPYILRYALFLGVPKHVIPT-------KV-D--LLPRSLFNVLANIIGI-L-DEE------ERLKA-MADLQYLR-RYL---------------------------TLT-QEN-----LPK-------YPRILE-RLKEIKAFVDNKFKDEAFLERLSKS-EDV---FLV-KE-------GEE--LFL-VVGDTATYIQASGRVSRLTAHGLLKGLSVVLV--ED--LRAFRSLERRLR-FQLGEE-FSF------V-----------------PL------------EN------L-------DLKELSCELTEVRQLKR----N-A
>WP_011994517.1 reverse gyrase [Fervidobacterium nodosum]
--------------------------------------------------------------------------MIE---------------------------------------------------------------------------------------AIFKNLCPNCGGDITS-ERLLNGLLCEKC-LPQ-Q---------------------------VS-KEF----LC------EHI-------K--EEKY--DLC--SLKERYNDWEKVFRKFI-GFDPWELQKFWARKLLLGRSFALLAPTGIGKTSWGLATALYF-S--K-------KG-K----RSYIILPTKLLILQS---YEKLK-----------------D-KV---KES------------DLLVFGLDE---SNKERE-EKKKRLAN-GDF-K------ILITSSMFLYKNVDL-I-P---KD-----FAFIFVDDVDSFLKT-AKNIDKALYLLGFDE--KDISFT-------MNYIKMK----------------------------RTQ-ANE------EK-------V-----------KAMQEEVRK-IA--SK-AK--G-VM--VVASAT--SDPKSE-RIRLFKELLSFDVGRPIF-YLRNVEDVYE----EV------------------ENL-DDALV------------RTVKRLG-K---GGLVFLSSDFGKER-------VDYIKNLLESN-GIKTETYENL--S----PEVLEKYRKGEIEVLIGISSYRNPLARGLDMPEVIRYAVFYGVPKIVVNL-------DI-E--GNVKHLLLALSSIRPL-I-ARDKDLEE-KVSLV-DKWMKALK-KFS---------------------------SMP-----------N-------PP--VD-KVNELKNEIKNFILSKEIHEKISNS-DEV---VLR-QE-------DEK--WIL-VVSDITGYLQASGRTSRLYVGGISKGLSYILV--DD--KKVLNNLLKKSR-WWFSTD-ITF------K-----------------EA------------RS------I-------NIDEILRQIDEDREKVRR------
>RUM28243.1 reverse gyrase [Aquifex sp.]
--------------------------------------------------------------------------MTL---------------------------------------------------------------------------------------QLIERGCPNCGGVISS-DRLEKALPCSKC-LPK------------------------------P-EEK----VCDALTELKNL-------K----YLK-PFC--DTDKKLEDFTLFFEKAV-GAKPWSLQRVWAKRVFMNQSFAIVAPTGVGKTTFGLVMSLFL-K-------------G----RVLMIFPTRLLANQA---GDKLQ-EI----SDK-------L-GL----QR------------KILVYQ-SK--------K-KIKEQFLK-GDW-D------ILIGTNMFLHKNFEN-L-M---NF----KFKLIFIDDIDSFLKR-GKNVDNLFKLLGFTD--EEIKLA-------LK---------------------------------EEK-SQR----DYDR-------L-----------ARIRKR--K--------KD--T-VL--IVSSAT--LKPKGK-RAYLFRNLLGFDVQKAIT-TLRNIVDVAK----PVLN---------------LEEA-LEKSA------------ELIKNLG-K---GGLVFLSVFYGKEK-------IEEIKEYYRSK-GINAVSYLDY--KP---EELYQILEKGDFDVALGISHITNPLVRGIDLPHIIRYAIFLDPPKHVFPT-------QI-N--LNPSLLYSLLLTLLNL-F-EEE------DRLKA-VQYITYLK-RYL---------------------------TLR-EEQ-----LDN-------YPKIKE-KVEEIKNFLEKFLQDEKFLKRIQQS-DDI---SLE-PK-------DGK--LYI-VIGDANSYIQASGRTSRFIAGGMTKGLSVVYY--SD--PKAFYSLKKRLTLYYMTQD-IEF------K-----------------RL------------EE------I-------DLEKLIKEIDQDRKRARAI-LE-G
>WP_066795663.1 reverse gyrase [Caldivirga sp. MU80]
--------------------------------------------------------------------------MRSSS--------------------------------SGSGEEP-------------------------------------------LV--LYHGMCPNCGGPITS-DRLGNGLPCHVC-LPE-VGR-----------------------LRAASLRE----VLNILNESGRL-------I----RLR-EMS--NHLAKYNEFCELFKRAT-GASMWGAQRFWARRLVKGKSFAIVAPTGSGKTTFGIVASLYV-AS-K--------G-G----KVLMVFPTSTLAYQV---YKKTL-SY----RDA-------V-NS---GVR-------------VVTYN-GLL--SDKDKE-ESLKAIKS-GDF-D------VLIVTNAFLPKGMEL-L-GR--F-----RFNLIFVDDVDSVMKVSSRNIERLLLLLGVPG--EAIDKA-------LEVAKA-R---DQK---E----------R------ETR-LSE----LRR-----------------------------MLE--GK--V-IG-SL--VVSGML--TRVRRTARAALFREILGFDVGGRAE-GLRNIVDLYI----KPGG-----------------DV-RRIIL------------EVVRRLG-D---GGIIYVPTDMGREF-------AEELAKYLADN-GVNVGLYLKP---K---RKLLEGFEEGLIPVLIGLATLRSALVRGIDLPHRIRYVVFAGVPKMRFRL-------SM-EE-FNPGRYIMLLSSLRVI-A-PNE------YKLRI-DKAVAGLR-NIMT---MSQD---RINQLI-K--------ALE-SGE-----QLQ-GF----DKYASE-VISNAVKLAQELLNRDEVKEAMGKS--IV---NIQ-RV-------GNE--IYV-ILPDSPAYIQGTGRASRMFLGGITHGLSVLIV--DN--EAVFNSLSRDLK--YRLVD-FQF------I-----------------KY------------ED------F-------NIDELLKTINEERELIRQI-MS-G
>RLF42634.1 reverse gyrase, partial [Thermoplasmata archaeon]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFWIRRISSGESFAAVAPTGIGKTVFGLIISLFF-SL-R--------N-K----KSYVLVPTTILANQC---LENME-KF----CKA-------I-NK---SIGVNSDGD-----IRVAFYH-GKM--KKTEKK-KFVEILER-DNF-D------ILITTTQFLSKNFSM-I-KN--K-----TFDFIFVDDVDAILKG-SRNVDKILTLLGFRK----------------------------------------------------V-GKK----WEGE------------------------------------KK--G-VL--MVSTAT--AK-KGK-ATILFRELLGFDVGSSFF-TIRNIDDIFV----GEEK--------------------EEEIK------------KIMKKMG-K---GGIIYART---SEE-------AERYYEILKRE--FRIGIAISR--K----KNEYEKFERGEVDFLIGTASYYGTLIRGLDLPEKIRYVIFIGLPVLRIDYE------NI---------TPPLLRIIALS-FKKNER-----------------VR-EYIP----------ILPKLE-R---------------------------------DPK-KFEELKRLIKEISKEEKS--------EDL---VI------------SE--GKI-LFPDIRTYIQGSGRSSRLTERGLTKGASFIFE--ND--KDLVEAFKKRAS--YY--D-IEI------K-----------------HV------------KD------V-------DLDKIKREIDKSR--------V--
>WP_013736684.1 reverse gyrase [Metallosphaera cuprina]
--------------------------------------------------------------------------MNV------------------------------------SDDIPN---------------------------------------------IVYIQSCPNCGSNITS-LRLVQGLTCENCLADG-KIKINELSE-----------------------------LISILEEQNKI-------R----LLQ-NEK--NILNEEKNVVQLFRKVV-GTGPIGPQRSWIIRALRGESFAIVAPPGLGKTTFGIIMSLYF-AS-K--------S-Q----KSLMMFPTKTLVSQV---VQKIQ-EM----SKL-------L-DQ---------------P-PRVLYYS-SGI--TRSKKA-EFNKSLNE-RDF-D------VLISTSRYVMENLDE-L-NKI-------KYRYLFIDDVDAVLKS-SKSSITILKLMGFND--DNIGKA-------RELLRLSR---D-------------------------D--KS----SFEE-------I-----------RKIRKKFMG-----ER-------IT--IFSSAT--IT-KSN---PVFTSLVGFKPGSATI-YLRNVIDSFVV----------------------EENP-VIQVN------------QIVNKLG-P---GGLIFVPIDRGLKY-------AHEIEKGI-E--GLNVSVLSSNS------TKKLEEFENGSLDILIGVATHYGLLVRGIDIPWRVRYTLFAGIPKFRFKLG---------ET-MHPLAMLRILTILSVI-L----------KDPNV-TNTLKIVK-YKL--RKISTA---ALAMLA-K--------SVK-EGD-----LE------------DR-NLIKAYEIVNYYLKQKNVIEQISRF-GDV---SV-----------NGD---YI-SMPDYLTYIQASGRASRLYGGHLTTGLSVLLV--DD--TTLFELLKKRLS--FILEN-LSW------S-----------------PF--------DIENET------VGG----IGLKDIIKKIDSERSEIMRK-REMG
>ARM75802.1 reverse gyrase [Acidianus manzaensis]
----------------------------------------------------------------------------M------------------------------------NEQLPE---------------------------------------------VVYMNSCPNCGCDITS-SKLYRGSACHSC-VPN-DKTFNSLRD-----------------------------LINYLIDTNKL-------K----KLN-SYY--HNLLEFEKVEDLFKNIL-GSPPIGPQRSWIIRALRGESFAIIAPPGLGKTTFGIIMSLYF-SR-L--------H-N----KTLMLFPTKTLVTQV---IQKIQ-EM----SKS-------L-DF---------------T-PKLVYYY-SGL--SQSSKQ-ELEKAISQ-DDF-D------IFLSTSRYLMANFDT-V-FNH-------NYKYIFVDDIDSVLKS-GKSALVILKLAGFSE--EDIDTV-------RDLLRKSR---N-------------------------D--PN----VFDE-------I-----------RKIREKKIK-----DR-------IS--IFSSAT--IT-KSN---PVFSSLMGFRPGSASI-YLRNVIDSYAY---INSM--------------NDSDL-IALIN------------KIVNKLG-S---GGLIFVPVDKGTEF-------AQYIAKNISG---IKAEAISSSS------VKKLEKFEDGEIDSLVGVATHYGILVRGIDIPWRIKYALFVGIPRFRFKLG---------ET-MHPIAMLKMLTLISLI-V----------KDDNI-TKVYRIVR-NYL--RRTSPT---ALAMIA-K--------SVK-EGN-----IS------------DK-YIQEGYDIVNKYLKDKEILAKISEI-GDL---SI-----------IGD---YV-TTPDYLTYIQASGRTSRIFGGELTTGLSILLV--DD--KKLFELLNRKLS--LVLDS-INW------N-----------------II--------DIDNNK------IGN----WDLLDLKNKIESEREKIEKI-KKEG
>RLG65949.1 reverse gyrase [archaeon]
--------------------------------------------------------------------------MT--------------------------------------GKVSE----------------------------------------VNTIPAIFSGLCPNCGGDIDS-QRLQLGIPCEKC-LPN-LNIE-ELKS----------------KNRIERIEY----IARLLEKRNLL-------K----NYS-EIY--RLEKLYNEFEEFFKFLI-GNKMWSAQRSWARRIFLGRNFSIIAPTGMGKTSFGAVMSLFL-AL-R--------G-K----KCYIMLPTSILVRQV---ADKIQ-SM----IEK-------G-GY--N-IR-------------LVYYH-SLL--TPKQKR-EMKARIMN-EDY-D------ILITTSFFLAIKFEE-FLKG--R-----FFDFIFVDDVDAFVKT-SKNVDKVLMLLGFTE--EIIDAG-------MRAAKLVT---RAF----FDKSA------------YEE-LRK----LREE-------I-----------AEFKSSHRV------------G-ML--VVSGAS--ARAKRTLRVKLFKELLNFEVGRRVE-GERNVVDAYL----FPEK-----------------SI-EEHVV------------DLVKRLG-K---GGLVFAPMDKGSEY-------VTTLAKTLKEH-GIKAEAYTSA---R---KKLLDQFVNGEIEVLVGVASYRSPLARGLDLPETVRYAVFAGIPKFKISL-------DL-RERFHTFKLFILLANIVEL-L-EGE------ELDEW-SRKLSWLR-TTLS-RLTSEQ---EL-ILN-R--------AIV-ENE-----QLT-GR----LEHIRQ-RILEIRDQLQKLLEREDIKEKIKTS-PRL---TLE-EN-------A-----YL-ITADAVAYLQASGRTSRMFIGGMTKGLSVLIV--DN--EKAFRGLLSRLK--W-LED-IQF------V-----------------DF------------RE------V-------NIESLLEEIDRDRKLIADL-RR-G
>WP_110271826.1 reverse gyrase [Acidianus brierleyi]
--------------------------------------------------------------------------MAL------------------------------------DYDIPN---------------------------------------------IIYMNSCPNCGSNISS-LRLYKGSACEKC-IKE-DIVFNDLNN-----------------------------LIQYLNSNSNL-------G----LLK-DFK--NILDNYNKVVVLFNKIL-NSPPLGPQKSWILRALKGDSFAIVAPPGLGKTTFGILMSLYY-SS-K--------N-I----KSLMVFPTRTLVQQV---TQRIQ-QM----SKD-------L-DN---------------V-PKLAYYL-SNL--TRSQKE-ELKKSLDA-SDF-D------IFVTTSRYLINNIAD-I-NPE-------QYGYLFVDDVDSVLKS-SKSSSTILKLMGFND--TDIQNV-------KELLRKAR---N-------------------------D--DT----VFEE-------I-----------KKIREKKIG-----KK-------IA--IFSSAT--IT-KGN---PVFSSLMGFKPGSAVI-YLRNVIDSYIQ----------------------SNDI-ISITK------------SIIDRLG-S---GGLIYVPIDKGTSF-------AKELATALDG--NLKVDAISSSS------TSKLEKFEKGDIDILIGVATHYGILVRGIDIPWRVKYAVFAGIPKFRFKIG---------EK-MHPLAMLRMLTLISLV-L----------KDPEI-SKILRIVK-FRL--RNISPA---ALNILA-K--------NVK-DGT-----LN------------DQ-YMLKAYEIVNKYLKDKELLEKISEI-GEI---SI-----------NGD---FI-STPDYLTYIQASGRTSRIFGGELTTGLSILIV--DD--TKLFDLLNRRLS--LVLDD-INW------H-----------------QF--------DIENDK------IGN----LEIDKILEKINSERDQIRKI-KESG
>WP_087036604.1 reverse gyrase, partial [Thermococcus litoralis]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIQT---IKRVQ-TF----AEK-------A-GV---SVN-------------LAYYH-GNM--KKKEKE-EMLQKIQN-GDF-D------ILITSAQYLARNFD-LL-KD--K-----RFDFIFVDDVDAFLKA-SKNIDRSLILLGFTE--EIIQKA-------WEIIKLKK---QMA---KYLNGN-SKDKN-------EK-LKE----LNKQ-------I-----------NAVEREIRKFKR--EN--K-IG-VL--IVASAT--GSARGD-RIKLYRELLDFEVGSGRS-ALRNVVDSYI----FPEK-----------------PI-EEHVK------------ELLKALG-S---GGLIFVPIDQGIVY-------AEKLTNYLQDL-GFKVELVSAR---N---KKGLERFEKGEVDYLIGVATYYGSIVRGLDLPHLIRYAIFTGVPKFRFSI-------DL-EQ-PTIYRVLGLMSEVMEF-L-ENE------DRRNA-EKLYARLR-RLI--RNIPQF---EILKIE-E--------ALA-EGL-----PLE-GF----SNHVLE-VFKEAVEFLRSVLKKPEVLKRIEED-PFV---SLK-KE-------EGK--WYI-EIPDVRTYIQATGRTSRLFAEGITRGLSVVIV--DN--EKVFNGLKRQMR--WRFAE-FDM------K-----------------PF------------NE------L-------NLEELLKEIDADREKVRLI-ME-G
>RLG64090.1 reverse gyrase [archaeon]
--------------------------------------------------------------------------MT--------------------------------------GKVSE----------------------------------------VNTIPAIFSGLCPNCGGDIDS-QRLQLGIPCEKC-LPN-LNIE-ELKS----------------KNRIERIEY----IARLLEKRNLL-------K----NYS-EIY--RLEKLYNEFEEFFKFLI-GNKMWSAQRSWARRIFLGRNFSIIAPTGMGKTSFGAVMSLFL-AL-R--------G-K----KCYIMLPTSILVRQV---ADKIQ-SM----IEK-------G-GY--N-IR-------------LVYYH-SLL--TPKQKR-EMKARIMN-EDY-D------ILITTSFFLAIKFEE-FLKG--R-----FFDFIFVDDVDAFVKT-SKNVDKVLMLLGFTE--EIIDAG-------MRAAKLVT---RAF----FDKSA------------YEE-LRK----LREE-------I-----------AEFKSSHRV------------G-ML--VVSGAS--ARAKRTLRVKLFKELLNFEVGRRVE-GERNVVDAYL----FPEK-----------------SI-EEHVV------------DLVKRLG-K---GGLVFAPMDKGSEY-------VTTLAKTLKEH-GIKAEAYTSA---R---KKLLDQFVNGEIEVLVGVASYRSPLARGLDLPETVRYAVFAGIPKFKISL-------DL-RERFHTFKLFILLANIVEL-L-EGE------ELDEW-SRKLSWLR-TTLS-RLTSEQ---EL-ILN-R--------AIV-ENE-----QLT-GR----LEHIRQ-RILEIRDQLQKLLEREDIKEKIKTS-PRL---TLE-EN-------A-----YL-ITADAVAYLQASGRTSRMFIGGMTKGLSVLIV--DN--EKAFRGLLSRLK--W-LED-IQF------V-----------------DF------------RE------V-------NIESLLEEIDRDRKLIADL-RR-G
>PHJ13947.1 reverse gyrase [Fervidobacterium sp. SC_NGM5_G05]
--------------------------------------------------------------------------MIE---------------------------------------------------------------------------------------AIFKNLCPNCGGDITS-ERLLNGLLCEKC-LPQ-Q---------------------------VS-KEF----LC------EHI-------K--EEKY--DLC--SLKERYNDWEKVFRKFI-GFDPWELQKFWARKLLLGRSFALLAPTGIGKTSWGLATALYF-S--K-------KG-K----RSYIILPTKLLILQS---YEKLK-----------------D-KV---KES------------DLLVFGLDE---SNKERE-EKKKRLAN-GDF-K------ILITSSMFLYKNVDL-I-P---KD-----FAFIFVDDVDSFLKT-AKNIDKALYLLGFDE--KDISFT-------MNYIKMK----------------------------RTQ-ANE------EK-------V-----------KAMQEEVRK-IA--SK-AK--G-VM--VVASAT--SDPKSE-RIRLFKELLSFDVGRPIF-YLRNVEDVYE----EV------------------ENL-DDALV------------RTVKRLG-K---GGLVFLSSDFGKER-------VDYIKNLLESN-GIKTETYENL--S----PEVLEKYRKGEIEVLIGISSYRNPLARGLDMPEVIRYAVFYGVPKIVVNL-------DI-E--GNVKHLLLALSSIRPL-I-ARDKDLEE-KVSLV-DKWMKALK-KFS---------------------------SMP-----------N-------PP--VD-KVNELKNEIKNFILSKEIHEKISNS-DEV---VLR-QE-------YEK--WIL-VVSDITGYLQASGRTSRLYVGGISKGLSYILV--DD--KKVLNNLLKKSR-WWFSTD-ITF------K-----------------EA------------RS------I-------NIDEILRQIDEDREKVRR------
>WP_008084248.1 reverse gyrase [Aciduliprofundum boonei]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------VIYGELCPQCHDKLSW-KEIENN----LC-ENT-G-------------------------------------------------------K--------ELSRTRESEIYGEFEKFFVEKF-GSKPRAIQRMWARRVLAGKSFAAIAPTGIGKTSFGILMSMFL-AR-K--------G-K----KSYLLVPTTIILKDM---VKKFE-DL----G------------------------------EDIAFYH-SKM--KGEEKK-GMENRIKE-GKF-N------ILITTTAYLARNHKN-L-YG--K-----FFHFIFVDDVDSLLKR-SKNLEKVLKIL--------------------------------------------------------------------H------------------------------------KK--G-VL--MVSTAT--GT-KGY-NTKILRDKLGFDVGNMRN-AVRNIEDIYA----SK-----------------------DTLK------------DILNAMG-S---GALIFAPT---AKE-------AKTLADRIGD----KAGLVIEK--D----KRAYDDFQAGKLDYLVGVSTPYGSLIRGIDMPDRIRYVIFYGIPRFKINAE------NL-D-----DFGDKLMLSLAYG-LRDYG------------------FD-EYI----------------------------------------------------KNR-NVKEIREKLKSILQNRKDIRG-----EDF---IY------------KN--GHI-IFPDVKTYIQGSGRASRLYAGGITKGASFLLD--GD---DMVEIFLQRAE--LY--G-IEF------K-----------------SL------------ED------V-------DIESLKREIDRDRRRI----AE--
>RLF11396.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------------MH----------------------------------------------------------------------------------------AIFSRLCPNCGGDIDD-ERLFKGLPCRSC-LP-------EVPD-SIGK--------LSYTSPLELKLA----VGKLLEAEGRLSGL----K----PYL------ELMEKLRDFEEFFSAVT-GKKMWSAQRAWAKRALSGQSFAVIAPTGVGKTLFAVTLTLYY-AR-H--------G-R----KILFILPTIVLANQV---YEWLL-KY----SEK-------A-SM---SLRV------------VPLFG-GRI----RDKE-EAFDAIKN-GLV-E------VVVTTPMSLAKNFDR-M-KG--V-----KFDLVAVDDVDALLRR-SKNIDRVLNLMGFSD--EAVDVA-------MRIVKERA---RIV---GLLRTGR-----------RDK-VEE----HRVR-------L-----------NELTEKLKDITS--RG--S-YG-QL--VVLSAT--GRARGL-RVRLFRELLGFEAGTIME-YMRNIQDCYV----VVEGGE-------------AEDL-MKPTL------------ELVKKLG-G---GGLIYVSYDLGADY-------AEALTEYLKSN-GVKAAFARSGARGI---KKLIEEFASGGLEVLVGVASYYGVIVRGLDLPERVRYAIFVAVPKFKFTL-------EA-EE-NQPVRLLQIMSVFQTI-V-EEE------EASQI-ARMIAEMR-RHA--LRLRYD---EARLIA-D--------ALR-KGV-----KLE-GY----LEEVRE-LFARAKARINELLKDEEIKRRFLES-PLI---DVR-EI-------EGT--LYM-FIPDVMTYIQASGRTSRMYTGGLTRGLSVVVYLPED--QHALDNLIKQTR--IYIDD-VQW------K-----------------PL------------SE------V-------NLEELLKEIDEDRVKARMA-LM-G
>RLG03429.1 reverse gyrase [Thaumarchaeota archaeon]
------------------------------------------------------------------------MEVR----------------------------------------------------------------------------------------AIYSFACSNCGGEITD-ARLMEVGVCERC-L-----AG---------------------EAE--NLLE----ASRVLRSLGKL-------R----KLR-EYL--RIQLEYESFRKTFEKAL-GFEPWALQEVWAKRILSGDNFAIVAPTGVGKTVLGLIMALHL-YK-R--------G-K----RCYLITPSSILAQQL---YEKAL-SY----AKR-------L-GI---RSLE-----------NIMAYH-AGL--PKAERE-KTLSRIAD-EAGRL------LLITTDRFLVDHGDL-LMEA--D-----PFDYVFVDDVDSFLKS-PKNIDKAISLLGLRP--EAADLA-------LKLIEVRI---KLA---K----A-------------SS--KD----LAEE-------Y-----------ERLAESVEREKR--RR--K--G-IL--VVAGAT--IRGRKTRRMMVFEELLDFEVGRFQE-FVRNVEDLYL----RAE-GD----------------P-VREAV------------KLIKRHG-G---GCLVFTPHALGRSY-------AEQVAKRLEEE-GLKVYVYRKM---E---TDILQRFSEGEIDVMVGLAASRSPLTRGIDLPARIRYAIFVGVPRREIEI-------EK-EE-YNPTKLLILLANILPI-L-DEK------TKRRS-EAIIARLR-KIIP---LGRD---LIEKIR-K--------ASS-EGI-----KLE-GF----EGYAQD-AILAARRFVEEALE-RKLLEQVEAR-LDV---TLK-PS-------EKG--FTL-IMPDAIGYIQASGRTSRLYPYGITRGMSIVVV--DD--EKAFKGLLSRLK--AQLEE-LDF------E-----------------PY------------DP------K-------NAELIFRQIDEERRLIREI-QA-G
>RLE77734.1 reverse gyrase [Thermoprotei archaeon]
-------------------------------------MRHFS------------------------IRLTSGSLAI----------------------------------------------------------------------------------------AVFKRLCPICGGEISA-ERLKAGMPCARC-LHA-NPGT--VLK-SVPS------------------------------------------S----KWG-QLV--LIKREVEKLDNFFRKSI-GSRMWSAQKLWAKRVFLNKSFAIIAPTGSGKTVFGVILSLYL-AS-K--------G-K----KVLFVLPTSILVEQV---SEKAE-TF----KNK-------I-GL--EHIT-------------LAYYH-SFL--SKKNKE-KMLATIEK-GEA-S------IVIVTSNFISRYSSL-L-SK--R-----RYDLVFVDDVDSILRS-SKIFDKILTYIGFSF--ETIDLA-------LKLLDAKT---NLNK-ARRLGLE-------------KE-VRK----NSKK-------V-----------DRLTKKLKNRLR--NE--K-PG-IL--IVSGAS--LRGRRTKRVKLFRELLGFDVGSKTE-YLRNIVDLYV----NTTD------------------L-EREIV------------NLIKRLG-P---GGIIFVPQDKGLEY-------VRKLNEILREA-GIKSEAYLKP---R---KGILKRFSNGESSVLIGIASYRSPLTRGIDLPHVIKYVIFAGVPKFRISL-------NI-DD-FKPSRMIILLANLRDF-L-DRR------TRYEC-DRHIVKLR-NIV---MLYKE---SLDRII-D--------AIK-TGK-----KLV-GF----EGYAQN-VITSIYNFLNKILSNREVVEKIKSE-ASL---KIT-ID-------DRG--IWF-VLADPIAYIQGSGRTSRLYSGGVSKGLAITVV--DD--DKAFKQLKEELA--NRLND-FEW------K-----------------NI------------SE------V-------DLDNLIEEISRERELIKLI-IE-G
>WP_015591802.1 reverse gyrase [Archaeoglobus sulfaticallidus]
---------------------------------------------------------------------------MQ---------------------------------------------------------------------------------------VIYEGLCPVCDGDLSL-NEIEAT----IC-NAK-R-------------------------------------------------------Q--------SLCR--EDYEVEEFVSLFNSCV-G-RIRKLQLLWAKRVLRNESFCITSPTGSGKTAFGLAMSIFL-AK-K--------G-K----KCYLIFPTTVLVVQA---FERIN-SM----LES-------L-KL---N-------------LKVGYYH-GKL--KKEEKE-DFMKNIGN---F-N------IIITSSQFLSKNFDV-L-KN--Y-----RFDFIFVDDVDAILKA-SRNVERILTLLGLNP--EL-----------------------------------------------DG-KNP----AENK------------------------------------GI--G-CL--VVSTAT--AK-KGK-KAELFRKLLNFDIGSPSH--VRNIEDFVI----MHDE--------------------IEALK------------NIMRELG-N---GGIIYT-S---SER-------IGELTEKL-NE--FRIGVVTS---K----KNDFEMFKAGEVDYLIGTAHYYGSLVRGLDLPEKIRYAIFVGFPVFKMKVE------DI-D-----SASENQLRIIARI-LGIN-------------------------------------------------------------------------------A-NDAKLKEKIKEAMKKERI------V-SDV---VV------------KD--NTI-TFPDLRTYIQASGRTSRLLSTGLTKGASFVIE--KD--ADLVSAIIKRAR--YY--D-IEFR----MA-----------------NL------------DE------I-------DFDRLKREIKESR-------QR--
>WP_012185865.1 reverse gyrase [Caldivirga maquilingensis]
--------------------------------------------------------------------------MRDNKG------------------------------DGGSG-EP-------------------------------------------LV--LYHGMCPNCGGPVTS-DRLRDGLPCHVC-LPE-GSR-----------------------LRAASLRV----VLSELNREGRL-------V----RLR-DIF--NYLMKYDEFSELFRKAT-GTSMWGAQRFWAKRLIKGKSFAIIAPTGSGKTTFGLVASIYV-AS-K--------G-G----RVLMVFPTSTLAYQV---YKRAL-TY----RDS-------A-AV---NIK-------------VITYN-GLL--SEKDKS-EVLNAIKA-GDF-N------ILIVTNAFLPKGMEI-L-SK--Y-----RFDLVFVDDVDSVMKASSRNIERLLQLLGVPR--EAIDKA-------LEIAKI-S---DFK---E----------R------EGK-VSE----LRR-----------------------------ILE--GR--R-IG-SL--IVSGML--TRTRRTARAALFREILGFDVGGRAE-GLRNVVDLYI----KPKG-----------------DL-KVIIL------------DLIRRLG-D---GGIIYVPTDLGREF-------AEELSKFLNDN-GINAGLYLKP---K---RKLIEGFEDGSIPVLIGLATSRSALVRGIDLPHRIRYVVFAGVPKIRFRL-------SL-KE-FNPGRYIMLLSSLRVI-A-PSE------YKTRI-DKTVSSLR-NIMN---LSQD---RINKII-E--------AIE-RGE-----SLQ-GF----DKYASE-VISNAIKLAQDLLNRDDVREAMSKS--IV---NIQ-RM-------GDD--IYV-ILPDSPAYIQGSGRTSRMYLGGITHGLSVLIV--DN--EAVFNSLSRDLR--YRLVD-FQF------I-----------------NY------------EE------F-------NVDALLKTINEERELIRQI-MT-G
>RJS80291.1 reverse gyrase [Candidatus Bathyarchaeota archaeon]
--------------------------------------------------------------------------MTL---------------------------------------------------------------------------------------VVYEGLCSVCNGDLRH-EEIEGK----RC-EVK-G-------------------------------------------------------V--------PFILSFQRDEEREFEEFFERAV-G-KPRELQRFWMKRLVRGESFAAVAPTGIGKTAFGLAFSLFY-AL-K--------G-K----KSYILVPTTFLVGQC---VEWLN-EF----GKK-------A-SM---RVKVNEEGE-----VTVAFYH-GRM--RKNEKE-RFEKLVRR-GSF-D------ILVTTTSFLSRRFND-L-KG--R-----IFDFIFVDDVDAILKS-SRNVGRVLFLLGLRK----------------------------------------------------E-PDG----WVGS------------------------------------PK--G-VL--MTSTAT--AT-KGK-STRLFRTLLNFDAGSSFF-TVRNVEDIAV----NGVD--------------------VEKVK------------EVLRRMG-R---GCLLYVRT---AEE-------VERWHNILKDE--FKIGMITAE--R----KRDYELFKDGRIDHLVGTSHFYGLLVRGLDLPEKIRYVVFIGAPTMKFRYE------TL---------TPKVIKILALI-FKRNEK-----------------IR-RYLP----------IIMNLE-R---------------------------------HPD-KLEEMRNLIRIVSKTEEA--------EDI---IV------------SE--DEI-IFPEVRTYIQGSGRTSRLTAHGLTKGASFLFE--DD--ERLLKAFLKRAE--YY--D-VSF------K-----------------SL------------DQ------V-------DLDSLSEEIDESR-------RR--
>WP_014452033.1 reverse gyrase [Fervidobacterium pennivorans]
-----------------------------------------------------------------MEVVAQQASALE---------------------------------------------------------------------------------------AVFKQLCPNCGGDISS-IRLVKGLPCENC-LKE-D---------------------------IEGKEA----LCR-LSNLKGL-------K--G------FC--KLNEEYEEWERTFRKYV-GFEPWELQKFWARKLLLKRSFALLAPTGIGKTSWGFASAIYF-A--K-------HN-K----KSYIILPTRLLVLQS---YEKLK-----------------D-KV---PAE------------DLLVIGMEE---SKKEKD-KNKERLAN-GQF-K------ILVTTSMFLYKNVDL-I-P---RD-----FSFIFVDDVDSFLKT-AKNIDKALYLLGFEP--RDIELT-------MKYIRMR----------------------------RNV-TEE----NVEE-------I-----------NSLREQVKR-IS--KK-AK--G-VM--VVSSAT--SNPKSE-RIRLFKELLSFDVGRPVF-YLRNVEDVYE----VVG--------------ANQTIL-DNMLV------------EKIKQFG-D---GGLVFVSSDYGKEK-------VDELKELLSKH-GITSESYENF--S----EEVLEKYKNREIQVLIGISSYRNPLARGLDIPEVIRYAVFYGVPKIVVSL-------DL-E--GNVKHILLAISTLRPL-I-ARDKELEK-WTMTI-DKWMKELK-KLG---------------------------NIP-----------N-------PP--KD-RVEQLREEIKKFILSEEITKKIKSA-DDI---TLR-QE-------GGK--WYL-VVADVTGYLQASGRTSRLFVGGITKGLSYVLV--DD--KKVFNNLIRKLR-WWFSSD-VVF------K-----------------EA------------QS------I-------DFGMLIKEIDNDRERVRK------
>WP_083756332.1 reverse gyrase [Hyperthermus butylicus]
--------------------------------------------------------------------------MTGFLPTRTTL-----LGAAVACAISHPLKPWCRVPTRGDGSIYAFPFFCKAFSGLVLP--ALQFYTLRCLKRTLHVWDGGKLALTLTLRPVYHAACPNCGGPISA-VRLVEGLPCVQC-LP---TVGELST------------------DYYERIET----IGRLLAENGRL-------R----GYW-YLY--SSTSQLREFEEFFEKLT-GHKLWSAQRTWAKRMLQGESIAIVAPTGVGKTTLLSVYAVYR-AS---------QG-L----KVYYLLPTENLARQV---TRKLE-TL----SSR-------L-GG---G-------------IRVVSYY-SSL--PKRAKE-ESLRTIEE-RSY-D------ILVTTTAFLSRRWSL-I-EG--IR-----FDSILVDDVDAVLRN-SKNIDKLLQALGFSV--EAIEAA-------YNLVKKKI---MATI-AKTSGN-------------IKR-YEK----LLQD-------I-----------EQLEAILSQELVK----TT-PG-QL--VIASAT--GRAYGL-KPKLFRELLGFDIGRVYD-YTRSIANLYK----IVNDP-------------------VAEAV------------SLVTRMG-G---GGLVFVAKRFGKNV-------ARRIAEMLNER-GIRAAVALAG-------RRVLDRFASGEYDVLVGVASYYGVIVRGIDMPERIHYTVFVGVPSQAIEAGK-----AL----LSPHRIARSAVELS--------------------LEGAEELA-RRL--SKLAPN---EVTVLR---------IALE-RGE-----RLE-GRLGEILEMLLE-TRRKLLHAIEELVSIE---GSVAVG-G-A---LY--RF------EDGK--LVA-ILPDAPTYVQASGRASRMYGSAMTHGISIVLD--VD--EILVRLLAEKLK--RFLED----------V-----------------RF------------EE------L-------SSEKLAKELEKARASRRG-----G
>OYT38349.1 reverse gyrase [Candidatus Pacearchaeota archaeon ex4484_31]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------ALFINFCPNCGSNISD-ERLSKASLCSKC-LSK-PLATNNYLK-----------------------------IFRELKQKGKI-------K----HYL-KLY--NFFKEKEKIKRMYEKVL-NNKPSALQETWINRVLLGKSFSIVAPTGIGKTVFGLITAIYF-AS-K--------K-K----KSYLMFPTSLLVQQA---EEKLR-KF----LKK-------L-NL---NIN-------------FLAYH-SAL--KQKQKK-EVLDAIER-NEY-N------ILITTNHFLVKNFEK-I---------NQSFDFVFVDDVDSFLKS-SKNIDKIIKLLGGNK--ELLEVG-------MKKIS----------------------------------KEK----LNAR-------E-----------EKMLEEVRQ-----KQ--K-LG-LL--VFSSAT--AKQRRTKKIRLFRELFGFELGFKPE-FLRNIEDIYVE--IKDESKK---------------EI-KEKVL------------ELVKKLG-N---GGLIFVPSALGTEF-------CKELDEWLNKK-GIKAWHYEKP---D---AKIIEEFRKGMFTVLIGIASYKSPLARGLDLPETIRYAIFAGIPRSEISL-------SI-ET-YNANKLLVLANSLVEL-IEDKE------KRLEL-EKVIVKLR-KIVP---LTKE---QIEAIEKN--------EIE-N-----------SF----LKHAKE-IVEKAQKVLKNLLS-KEFLEKIKQS-KEI---RLK-KD-------RQG--FKL-VVADPVGYLQASGRTSRLFVNGISKGLSLVVV--DD--QKAFYGLKKKLS--YYTEE-VEF------K-----------------EF------------EK------G-------LLEEIIKEVDKDRETIKKA-LS-G
>PMB75819.1 reverse gyrase [Fervidicoccus fontis]
--------------------------------------------------------------------------MQ-------------------------------------------------------------------------------------QVKGIYIRSCPNCGGPVSD-LRLSKGLACERC-LPD-INEE---------------------L----DFER----LLLKLKEEGSL-------K----ELK-KYY--NMEEMLKEFVDMFEKAL-RNPPWSAQITWAKRVFLNKSFSIVAPTGVGKTVFGMITALFF-SK-H--------K-E----KSMIVLPTRALVSQV---CEKLE-RF----KET-------L-EI---DAK-------------ILC-S-SML--RAGIKS-EVLEMLSK-GDF-D------IFVCTSKFMIRNSSI-LKRA--------GFRFFFVDDVDSVLKS-GKSIESLFNAMGFSS--EAINLV-------LEISRLRSL--AMR----------AQEDN------KSE---K----LRKE-------L-----------NEKLEKLKKEKE------K-IGAVL--VVSSAT--GSPKGR-KISLFKELLGFQVGTKTE-QLRNVVDTYK----VV--SD-------------E-DL-EKELV------------SLVKKLG-S---GGLVFVPSDMGTEY-------AKKIADLLNYI-GIKSEAISSK---N---IRSIKSFETGEIDVLVGVSIYYGILVRGLDLPHRVRYVIFAGLPRFKFTL-------QL-EN-IHPLNVLTILSLLSKA-N-IKD------VSEQA-KVYLKNIR-RIL--RSLSPA---AIQIIA-N--------------K-----LIE-GK---IENDIDR-AFMESIQFLKNSLKREDVKNYLLST-NEV---FVR-KE-------GEK--FFI-YVPDIKSYIQASGRCSRLYAGGLTKGLAITLVPKSE--NRLFEIFQRTAR--IYIES-ADI------K-----------------PL------------EI------I-------DLNQVLKEIDEDRKKVLKI-IE-G
>WP_011007733.1 reverse gyrase [Pyrobaculum aerophilum]
--------------------------------------------------------------------------ME----------------------------------------VP-------------------------------------------LV--AYLHSCPNCGGPITS-DRLASGLPCREC-LPD-GAK-------------------------AGSIKQ----VITALRKRKAL-------Q----GLA-WVE--AYLRGYEEFAEFFKRIV-GFEMWGAQRLWARRFVRGKSFAIVAPTGSGKTTFILIATLYS-AK-Q--------G-K----RALLIFPTSALAHQA---YKKLL-TF----AER-------G-GV---SLK-------------ALAYH-SLL--TEREKK-EALEALER-GDF-D------VLVTTSAFLPKRFEL-L-SR--Y-----KFDFVAADDVDSILRATSKNIDRILRLLGVSD--AVLNTA-------LEVINLTK---QLR---KAEV-A----GD------LKE-VER----LDQE-------M-----------AKLRAKLREEVQ--RL--K-LG-VF--VASGAL--AKARRTVRLLLFREILGFDVGGRAE-GLRNVVDLYV----EASD-----------------NV-IEQTL------------ALVKRLG-P---GGIIYVQD---REL-------GEAIVERAREA-GLAVEHFFRP---R---RGVLESFERGELAALVGLASSRSALVRGIDLPHVIRYVIFVGVPKFKFRV-------RL-EE-FSIPAYLTFLYNVRSV-L-AGD------ARYKA-DRLIGQLK-RLAP---YAL----SVQEAL-K--------KAS-EGA-----ELS-SF----DRHAVD-VVKSAVEFVNSLLQNEEIRKAIETS-SEV---KLA-YI-------DGE--MYV-LVPDVTTYIQGSGRTSRLYAGGLSKGLSVVIV--DD--PKVFHALKRELS--LRFDE-AEF------K-----------------HL------------GE------A-------DLDKILADVDRDRKTIRDI-ME-G
>AFH43289.1 reverse gyrase [Fervidicoccus fontis Kam940]
--------------------------------------------------------------------------MQ-------------------------------------------------------------------------------------QVKGIYIRSCPNCGGPVSD-LRLSKGLACERC-LPD-INEE---------------------L----DFER----LLLKLKEEGSL-------K----ELK-KYY--NMEEMLKEFVDMFEKAL-RNPPWSAQITWAKRVFLNKSFSIVAPTGVGKTVFGMITALFF-SK-H--------K-E----KSMIVLPTRALVSQV---CEKLE-RF----KET-------L-EI---DAK-------------ILC-S-SML--RAGIKS-EVLEMLSK-GDF-D------IFVCTSKFMIRNSSI-LKRA--------GFRFFFVDDVDSVLKS-GKSIESLFNAMGFSS--EAINLV-------LEISRLRSL--AMR----------AQEDN------KSE---K----LRKE-------L-----------NEKLEKLKKEKE------K-IGAVL--VVSSAT--GSPKGR-KISLFKELLGFQVGTKTE-QLRNVVDTYK----VV--SD-------------E-DL-EKELV------------SLVKKLG-S---GGLVFVPSDMGTEY-------AKKIADLLNYI-GIKSEAISSK---N---IRSIKSFETGEIDVLVGVSIYYGILVRGLDLPHRVRYVIFAGLPRFKFTL-------QL-EN-IHPLNVLTILSLLSKA-N-IKD------VSEQA-KVYLKNIR-RIL--RSLSPA---AIQIIA-N--------------K-----LIE-GK---IENDIDR-AFMESIQFLKNSLKREDVKNYLLST-NEV---FVK-KE-------GEK--FFI-YVPDIKSYIQASGRCSRLYAGGLTKGLAITLVPKSE--NRLFEIFQRTAR--IYIES-ADI------K-----------------PL------------EI------I-------DLNQVLKEIDEDRKKVLKI-IE-G
>RLF65261.1 reverse gyrase, partial [Thermoplasmata archaeon]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EINDLFKKIT-NNNMWPIQASWALRALKGYSFAITAPTGVGKTVFGIVFTYYL-AT-RF-------K-K----KCYLILPTSVLVKQA---YERIS-KL----NEL-------D-GQ---EVR-------------IVAFW-SGM--KNAK---ETKEKIFS-GEY-D------ILITTSQFLSQNFES-I-KD--Q-----KFDFIFVDDVDSFLKA-YRNIERSLILLGFTH--KEVEEA-------YKLIK-------------------------------------------------------------------ENKIGE-----KEFER-KG-QI--IISTAT--GKTKGR-AYLLYRVLLGFTIGSTTW-QLRNVINFYK----ITENT-------------------LETLK------------NLVLKLG-R---GGLIFVPHDLGHEY-------ASKIEEFLKEN-NIKALQVTPE--NK---LKALEAFVNGDVDILIGVAHYYGILVRGIDLPEIIRYSIFLGSPRFKFNL----------KELNDVSSISTTVIRLYRH-V-SDE------EARVI-DTVISFLR-R------ATKN---EIDIIN-K--------ALK-GES-----SPG------RLQRFYE-AFVKAREIVLRYLSDEEKRKEIEKE-GEL---IIR-RE-------DEK--LYV-YIPDTRTYIQASGRTSRTYVGGITRGISIIIERPDD--KPILEGLMRVFR--YYLEE--PW------E-----------------EL------------SE------E-------KLEEELRKVNEDRELVKLA-KE-G
>WP_064011090.1 reverse gyrase [Fervidobacterium pennivorans]
-----------------------------------------------------------------MDIVTQQPTTLE---------------------------------------------------------------------------------------AIFKQLCPNCGGDISS-TRLVKGLPCENC-LKE-D---------------------------IEGKEA----LCR-LSNLKGL-------K--G------FC--NLNEEYEEWEKTFRKYV-GFEPWELQKFWAKKLLLKRSFALLAPTGIGKTSWGFASAIYF-A--K-------HN-K----KTYIILPTKLLVLQS---YEKLK-----------------D-KL---PAE------------DLLVIGIEE---SKKEKD-QNKERLAN-GQF-K------ILVTTSMFLYKNVDL-I-P---RD-----FSFIFVDDVDSFLKT-AKNIDKALYLLGFEP--RDIELT-------MKYIRMR----------------------------RNV-TEE----NAEE-------I-----------NSLREQVKR-IS--KK-AK--G-VM--VVSSAT--SNPKSE-RIRLFKELLSFDVGRPVF-YLRNVEDVYE----DVG--------------AKQTIL-DSMLV------------EKVKQFG-D---GGLVFVSSDYGKEK-------VDELKELLNKH-GISSESYENF--S----EEVLERYKNREIQVLIGISSYRNPLARGLDIPEVIRYAIFYGVPKIVVSL-------DL-E--GNVKHILLAISTLRPL-I-ARDKELEK-WTPTI-DKWMKELT-KLG---------------------------NIA-----------N-------PP--KD-RVEQLREEIKRFILSEEIIKKINSA-DDV---TLR-QE-------DGK--WYL-VVADVTGYLQASGRTSRLFVGGITKGLSYVLV--DD--KKVFNNLIRKLR-WWFSSD-VVF------K-----------------QA------------QS------V-------DFGALMEEIDNDRERVRR------
>KUO91465.1 reverse gyrase [Thermocladium sp. ECH_B]
--------------------------------------------------------------------------M------------------------------------ANDG-FP-------------------------------------------PA--LYRWACPNCGGIIDA-DRLGTGLPCRLC-LPR-TPK-----------------------KR--DVLS----ILREMDKLGTL-------K----RMR-PIL--SMYMKYDELNNLFREIT-GFEMWGAQRVWARRLVRGKSFAVIAPTGSGKTTFGIVASIYT-AI-N--------G-G----KTLIVAPTSTLAYQL---FQRAE-AY----SKG-------K-A------R-------------IVAYN-SLL--TKKEKE-EAIKRIND-NDY-D------ILIITNSFLSKHMDL-L-AR--N-----KYKLIFVDDVDSVLKASSKNIDRLLVLLGVPK--EAIDVA-------LEAIKVXR---DTM---QALR-N----GN------EDD-LGE----LNRR-------M-----------RSIAKTIEEMMK--GR--N-IG-TL--IVSGVL--TRPRGTSRALLFREFLGFEVGGRAE-GLRNVIDLFM----QPKT-----------------NL-IEDAA------------NLVKRLG-G---GGIIFIPTDADREI-------AKKIAEKLGEA-GIKAGIYLKP---K---KKLLLAFQEGELDVLIGLATSRSSLARGIDMPARIKYVIFVGVPKIMFRL-------NL-AE-FMPIKFLLFFSGIRQI-A-PDE------LKRRV-DKMIARLR-RISY---LNQN---QXSEILTK--------AQQ-NIN-----ELS-GF----QRYVAE-TAMESLKLADELLKVPAIIDNINKS--EV---NIQ-LR-------NGE--FHI-VLPDSTTYIQASGRTSRMYIGGVTHGLSIIII--DN--PSVFTALQRDLK--YRLDE-AEF------K-----------------DV------------EA------Y-------DVDAIMQVINEERREVAEL-LR-S
>BAJ50464.1 reverse gyrase [Candidatus Caldiarchaeum subterraneum]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------SIYASLCPNCGGAITD-EELIGNGVCSRC-V-----S----------------------------------------QDG----------RLKPGKYT-KAL--ELEERYREFADFFSRVV-GSPPWSLQRTWIRRTFLGRSFSIVSPTGTGKTTFFIAMAIYQ-AS-K--------G-K----KSYIIVPTSLLAQQI---HERAL-SM----AAK-------H-GE---KAPK------------IAGYF-SGM--KKSEAE-EMLQKIRD-EEF-N------ILVTTDRFLNTRFEL-L-RG--K-----KFSFIFVDDVDSFLKS-ARNIDKVLLLMGFDE--EEIERQ-------LSLVSRRS---EKN---EA---G-------------E---------------------------------HASREIA-------K--P-DS-IL--LVAGAT--AKGRRTKRIQLFRRLLNFEPGGSIE-FVRNISNMY-----LRPSKN----------------M-WEQVA------------ELVKTHG-G---GCLIFVPQTAGVES-------AKELAKFLNSQ-GISAYAYERM---D---AKMLGRFELGEYDVLVGVASRRSPLARGIDLPERIRYVIFAGVPRRELNV-------SW-RE-HRPSMLLSLLRNLYSI-L-REK------NESEL-VQVTGMLK-KCVP---TDRE---VLEIVR-E--------GLE-SSR-----QPE-GF----AGYVYS-AVTRAHQLLKTYIG-EEELRRVAEN-LDM---RLR-VD-------ENG--VSI-ILPDIDGYIQASGRSSRMYAGGITRGISILIV--DD--EKAFRGISRALE--TIYEE--TF------Q-----------------EY------------TL------E-------QAREEFKQCDRDRQFLREI-RT-G
>TDA35845.1 reverse gyrase [TACK group archaeon]
-------------------------------------------------------------------------MIH----------------------------------------------------------------------------------------AKFRGLCPNCDGEITD-DRLLYGLPCTNC-LPD-SDIR-EASE-FI-D--------LYKSSPLDFRLK----LGELLEARGKLMGL----K----DYV------ALASKLKDFEDFFSKVT-GKKMWSAQRTWAKRALSGLSFAIIAPTGVGKTLFAVALTLYY-AK-Q--------G-K----KTLFILPTIVLANQV---YEWLR-KY----AEN-------V-ML---GIRV------------IPLFG-GHV----KDKE-GAFDAIRE-GQV-D------VVITTPMSLAKNFNK-M-VG--A-----KFDLVAVDDVDALLRK-SKNIDRVLNLMGFPQ--EVIDLA-------MRLVKEKA---KLL---GLLKAGR-----------KEK-VEE----IGIE-------L-----------GEINAKLKNSLA--NN--N-YG-QL--IVLSAT--GRARGL-RVKLFRELLGFEAGTMVE-YMRNIQDCHL----LVEGGG-------------PEDL-MRPVL------------DLVRRLG-S---GGLIYVSHDLGADY-------AQALTDYLVSN-GVKAALAKASMRGI---RKLIEDFARGELEVLVGVASYYGVIVRGLDLPERVRYALFVAVPKFKFTL-------DS-KE-SHPIRLLQIMSVLQTI-V-EGD------ETLRL-ARIVADMR-RHA--SRLGYE---EARLVT-D--------ALR-KGV-----ELE-GY----LEEVRQ-LFANARELMNELLKREEVKKKFLES-PVI---DVR-EI-------DGK--LFM-FIPDVMTYIQASGRTSRMYTGGLTKGLSIVVYLPQD--SNALNNLIKQTK--IYIDD-IQW------K-----------------SL------------SD------V-------DLEKLLKEIDEDRVRVKKT-LA-G
>WP_011839408.1 reverse gyrase [Staphylothermus marinus]
-----------------------------------------------------------------------MVELK-------------------------------------------------------------------------------------HIHGYYRYSCPNCGGEDSD-LRLIHKAPCDKC-IEE-ELFY-RIRE-NI-----------GEKSYKEILET----YYRMLLKNNKL------KK----RFE-FLY--KFEEKLEKFEKFFSEATGGYKFWSAQRTWARRLLKRRSFSIIAPTGMGKTMFALISSLYL-SK-KQIMIQKNRI-SRK--KIYLVFPTTPLLLQA---EKKLR-KL----AEQ-------E-KI---PVCQEEDSD-Q-TCLNIISIH-GRV--PKKKRE-KLLEEIRS-GNF-D------ILLSTNMFMHKNYEL-L-LD--K-----KYELIVMDDVDAILRS-GKAIRILFYILGLTD--QEINEA-------IEYLKLRQ---RLA----------------LKLS-EEE-RRE----LEEK-------L-----------ETLEKRIEKYKRKIDT-------VV--IVSSAT--GKPRGI-YPRLFRILLNFEAGSRAE-AIRNIVDTYT----YSKE-----------------SL-EQTII------------RLAKKLG-D---GGLIFVPIDKGVEY-------AETIAELLKKH-GINAEAFHAK--KA---VKLLEEFASGNIDILVGVATYYGVMVRGLDLPDRVKYAIFTGVPRHKFST-------RL-ES-PSPIDVLRIFTILRDV-L-EGE------EKRKA-EILIGRIS-LRL--RRLSQG---ALMKLK-E--------DFM-KKL-----QGE-EV---EEYPLLS-LLMEALSMARELLSKPEIWEKLKQK-GDV---ALV-QE-------DGK--SYI-LIPDVATYIQASGRTSRLYPGGITKGLSIVIV--DD--QRLLNGLIKRMR--WLFEE-FDM------K-----------------RL------------DE------V-------DLDKLMKEINEERRKVKMI-LE-G
>WP_013337362.1 reverse gyrase [Vulcanisaeta distributa]
--------------------------------------------------------------------------ME--K-------------------------------------QP-------------------------------------------LV--IYRRACPNCGGDITS-DRLASGLPCHRC-LPD-VPK------------------------KVASTIE----VLNMLEKLGTI-------N----RLR-SLA--NLVNEYNEFADMFRKII-GTNMWGAQRLWARRIIKGKSFAIVAPTGSGKTTFGMIASLYV-AL-K-------RR-G----RVLIVVPTSTLAYDV---HRRLS-DY----VNK-------M-GV---NVR-------------IVMAS-SIL--SKQELT-EAMKTIED-GNF-D------ILIVTNAFLPRHMDL-L-SR--Y-----RFSLIFVDDVDSVLKASSKNIDRLLLLLGINE--EALRKA-------LTVVDLMK---KLR---KAIRFR----AS------EEE-INK----IRED-------I-----------KRLNAELTNYIK--SN--N-IG-IL--IASGAL--TRMRRTARLFLFREFLGFETGGRAE-GLRNVVDVYV----RPRD-----------------SL-ISTAV------------DIVKRLG-S---GGIIYVPPDL-RDI-------VDELLEALNKN-GVKAASYLKP---S---KSLLNDFVEGKIDVLIGLATSRSSLVRGIDLPQRIAYVVFVGVPRMRFRL-------RL-EE-FTPIRYLMFLFTIRNV-V-PQY------LRNDI-DRVVARLR-NLTA---LNQE---QINNLL-K--------AIE-ENK-----ELS-GF----DKYAAD-VIKEAVDLVNKLLSDPNIRKAIEQS-NEV---GLE-YR-------GGE--LYV-IIPDVTTYIQGSGRTSRLYVGGVSQGLSVLIV--DN--EKVFNGLIRNLR--YRLED-VKI------Q-----------------DI------------NE------V-------NIDDLMKRIRSERDLIRNI-ML-G
>WP_008084281.1 reverse gyrase [Aciduliprofundum boonei]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------VIYGELCPQCYDKLSW-EEIENN----LC-ENT-G-------------------------------------------------------K--------DLSRTKESEIYEEFEKFFVEKF-RSKPRAIQRMWARRVLAGQSFAAIAPTGIGKTSFGIVMSMFL-AR-K--------G-K----KSYLLVPTTIILKDM---VKKFE-DL----G------------------------------EDIAFYH-SKM--KGEEKK-GMENRIKE-GKF-N------ILITTTAYLARNYKN-L-YG--K-----FFHFIFVDDVDSLLKR-SKNLEKVLKIL--------------------------------------------------------------------H------------------------------------KK--G-VL--MVSTAT--GT-KGY-NTKILRDKLGFDVGNMRN-AVRNIEDIYA----GK-----------------------DALK------------DILNAMG-S---GALIFAPT---AKE-------AKTLADSIGD----KAGLVIEK--D----KRAYDDFQAGKLDYLVGVSTPYGSLIRGIDMPDRIRYVIFYGIPRFKINAE------NL-D-----DFGDKLMLSLAYG-LRDYG------------------FD-EYI----------------------------------------------------KNR-NVKAIREKLKSILQNRKDIRG-----EGF---IY------------KD--GYI-IFPDVKTYIQGSGRASRLYAGGITKGASFLLD--GD---DMVEIFVQRAE--LY--G-IEF------K-----------------SL------------ED------V-------DIESLKREIDRDRRRI----AE--
>AFA40229.1 reverse gyrase [Pyrobaculum oguniense TE7]
------------------------------------------------------------------------------------------------------------------------------------------------------------------M--VYLHTCPNCGGPITS-DRLVLGLPCREC-LPE-GTK-------------------------AGSIRE----VVAALRRRRVL-------K----GLA-WVD--AYLRGYEGFTEFFKKVV-GFDMWGAQRLWARRLVRGKSFAIVAPTGSGKTTFVLVAALHV-AK-E--------G-K----KALLIFPTSALAHQA---YRKLL-VF----AER-------A-GI---SVR-------------ALAYH-SLL--SDREKK-EVLDAVQR-GEF-D------VLVVTSAFLPKYFDM-L-KA--F-----KFDYVAADDVDSILRATSKNIDRILRLLGVSD--SVLSTA-------LEVINMTK---QLR---KAEV-A----GD------LKE-MER----LSQQ-------I-----------AELRAKLHEEAR--RL--R-LG-IF--IASGAL--AKARRTLRLMLFREILGFDVGGRAE-GLRNVVDLYT----EASG-----------------DV-VEQAV------------ELLKRLG-P---GGIVYVQD---REL-------GMTILERAKAE-GLAVEHFFRP---R---RGVLESFEKGELVALVGLASSRSALVRGIDLPHVIRYVVFVGVPKFRFRV-------RL-EE-FSIPAYLTFLYNVRAV-L-ASD------LRYKA-DRLIGQLK-RLAP---YAL----SVQEAL-K--------KAA-EGA-----ELN-GF----DKHAVE-VVKSAVEFVNFLLEREEIRKAIETS-TEI---RLT-YV-------GGE--LYV-LVPDVTTYIQGSGRTSRLYVGGLSKGLSVMIV--DD--AKVFQALRRELK--LRFDE-AEF------A-----------------HI------------KE------V-------DLDKVLQEVDRDRRIIRDI-ME-G
>WP_013604017.1 reverse gyrase [Vulcanisaeta moutnovskia]
--------------------------------------------------------------------------ME--K-------------------------------------QP-------------------------------------------IV--IYRKACPNCGGDITS-DRLGAGLPCYKC-LPE-VAK------------------------KVANTIE----VLNTLEKLGTI-------N----RLK-SLS--NLINEYNEFMNMFKKVV-GTNMWGAQRLWTRRLIKGKSFAIVAPTGSGKTTFGMMASLYI-AL-R-------KR-S----KVLIVVPTSTLAYDV---HRRLS-EY----SGK-------M-NS---NIR-------------IIMAS-SIL--YKQELI-DAMNAIEN-GDF-D------ILIITNAFLPRHMDL-L-RK--Y-----RFSLIFVDDVDSVLKASSKNIDRLLLLLGINE--EALHKA-------LTVVDLMK---KLR---KAIRFR----AS------DEE-INK----LKED-------I-----------KKLSTELSNYVK--SN--N-IG-IL--IASGAL--TRIRRTARLFLFREFLGFETGGRAE-GLRNVVDAYT----RPKD-----------------SL-VSAAV------------EIVKRLG-G---GGIIYVPPDL-REI-------IDELSEKLNNN-GIKAAAYLKP---S---KSLLNDFVDGKIDVLIGLATSRSSLVRGIDLPQRIAYVVFVGVPRMKFRI-------KL-EE-FTPMRYLMFLFNIRNI-V-PQY------LRNDV-DRVIARLR-NLTA---LNQE---QVNNLL-M--------AIE-ENR-----ELS-GF----DKYAAD-VIKDAVDLVNKLLSDPGIRRAIEQS-NEV---GLE-YR-------GND--LYV-IIPDLTTYIQGSGRTSRLYVGGVSLGLSVLIV--DN--EKVFNGLVRNLR--YRLED-VKV------Q-----------------DI------------NE------I-------NIDELMKKIRNERELIRNI-ML-G
>RLG89367.1 reverse gyrase [Thermoprotei archaeon]
------------------------------------------------------------------------------------------------------------------------------------------------------------------MKVIYRASCPNCGGSIDS-ERLELGLPCRSC-LPK-E------------------------IEKLRDREQ----IANALINEGTA-------A----AFL-ELV--TIDNELKEFSNFFRKVM-KKTMWSIQRSWARRLLQWDSFAIVAPTGVGKTTLLIIYALYR-AI-Q--------N-Y----KIYIIVPTKEIAKQI---ALRMN-QY----VKE-------L-HR---E-------------LNIVAYL-PSN---NNERQ-ELLKKIQS-EDV-N------VLITTAAFLAKNYNV-L-KN--IE-----FDIVIADDFDAILRK-SKSINKVLNLLGFSE--ELIKKA-------FRIVTLRS---EILR-LRLLGFD------------AEN-LQK----LVTT-------L-----------NELEYELKRKLLQ----CR-KS-QL--IVASAT--GRSSSL-RSKVIRELLGFEVGGVIE-YMRRVVDAYT----KLRS--------------------FDQLI------------EIVKALG-S---GGLIFVSRNLGSYK-------AREILETLKSH-GIKAGLALSG-------SRAFEKFKRNEIEILVGVASYYGILVRGIDEPLKIKYAIFLGVPSFTFKLSK-----AL----LNPRFLLSIVIELR-----ERG------YS--D-LAWIESLLFKIL--KNMNYS---KISILM---------KALI-NGK-----ELE-GYLEDLRMKILM-AIEQVKKILNDILKEN---EKIIIG-D-----LII-KH------SREWREPRI-VIPDVMTYIQASGRTSRLLGNAKTYGLSIILV--DD--EDLLKALIRRLE--RYVPD-LEF------R-----------------KF------------EE------L-------NLDHIKKLMEDSRRCQQEN-SQ-S
>GAY26430.1 hypothetical protein ATG_16340 [Desulfurococcaceae archaeon AG1]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ML----------------TERLEIKDL-HMKIYGALVRSGKL------RK-SDLGYE-ELI--RIEESVKEFSEIFRKCI-GRDPWSVQIMWAKRIFRGSSFSLVAPTGVGKTTFGIIMAIYL-AY-K-------QG-----LRSILIVPTIPLASQV---FKKAT-EY----ARK-------L-SL--DEEK-------------IIIYH-SKI--SPSKRK-ETLNKLSE-GDF-N------IFITTSAFFRNKENVKLLAG--------KFNFFFVDDVDAILKG-GKILYQVFEAMGIGE--DIIRKA-------EEIVSLKT---RLA---------------------LRE-NTE----DLLR-------I-----------RELKRSIEASKKS-HV-------IL--IISSAT--GRARGR-GIRVLREIFGFEIGSRYD-VIRNVVDTYS----IVKSRI---------------DM-VKEAS------------EIIKKIG-S---GGIVYVPKDLGVEY-------AEKVAHELSKRTGLRVLPLTSKN------VKVIDKFARREIDVIVGVSTYYGVAVRGIDLPDIIKYAIFLETPRHRIPL-------DL-EQ-MDLFDISRILELSLDV-V----------DPSKK-DEILGILN-KIL--RIIRRS---SSSYLR-E--------VFE-KVM-----RGS------VESNTEK-IIKSAIDTVNMLLADKNFVSKLKKN-PYV---RVS-KH-------GSK--IYV-DIPDWATYIQASGRTSRLYVGGISKGLSIIFE--KD--HRLLKGLERRLR--LFSEE-FVL------R-----------------EL------------RS------I-------DLDEVIREIERDRNNIVKA-RE-G
>ABP49872.1 Reverse gyrase [Pyrobaculum arsenaticum DSM 13514]
---------------------------------------------------------------------------M----------------------------------------VP-------------------------------------------LV--VYLHTCPNCGGPITS-DRLVLGLPCREC-LPE-GTK-------------------------AGSIRE----VVAALRRRRVL-------K----GLA-WVD--AYLRGYEGFTEFFKKVV-GFDMWGAQRLWARRLVRGKSFAIVAPTGSGKTTFVLVAALHV-AK-E--------G-K----KALLIFPTSALAHQA---YRKLL-VF----AER-------A-GV---SVR-------------ALAYH-SLL--SDREKK-EVLDAVQR-GEF-D------VLVVTSAFLPKYFDM-L-KA--F-----KFDFVAADDVDSILRATSKNIDRILRLLGVSD--SVLSTA-------LEVINMTK---QLR---KAEV-A----GD------LKE-MER----LSQQ-------I-----------AELRAKLHEEAR--RL--R-LG-IF--IASGAL--AKARRTLRLMLFREILGFDVGGRAE-GLRNVVDLYT----EASG-----------------DV-VEQAV------------ELLKRLG-P---GGIVYVQD---REL-------GMAILERAKAE-GLAVEHFFRP---R---RGVLESFEKGELVALVGLASSRSALVRGIDLPHVIRYVVFVGVPKFRFRV-------RL-EE-FSIPAYLTFLYNVRAV-L-ASD------LRYKA-DRLIGQLK-RLAP---YAL----SVQEAL-K--------KAA-EGA-----ELN-GF----DKHAVE-VVKSAVEFVNSLLEREEIRKAIETS-TEI---RLT-YV-------GGE--LYV-LVPDVTTYIQGSGRTSRLYVGGLSKGLSVMIV--DD--AKVFQALRRELK--LRFDE-AEF------A-----------------HI------------KE------V-------DLDKVLQEIDRDRRIIRDI-IE-G
>ABL77980.1 Reverse gyrase [Thermofilum pendens Hrk 5]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------ALYKSLCPNCHGDISD-FRLEKRLPCRQC-LPE-KDAE-LFLSSETSRAP---------DPFFEHLER----LVKVLGKSGKL-------L----HLE-ELY--SVERDLADFQAFFRKAV-GSRPWSAQKTWARRVLRNTSFVILAPTGVGKTVFGIVMALFL-AS-R--------G-K----KSYIVLPTTTLAQQV---FEKAT-LF----ARK-------V-AV--NEGG-------------IVVYH-GGL--PQSKKE-EVLSRVSG-GDF-S------VLITTSQFLSRNFDK-L-ER--V-----RFDFVFVDDVDSIIKS-SKNIDRILRLLGFTQ--DEISVA-------LEIIRERV---RLA---RRLRNG-------------AS-TSD----VYER-------L-----------EELRRKLAEYTG--KGG-P-RG-VL--VVSTAT--GRPRGL-RIRLFRELLGFEIGSRGE-LFRNVVDTYV----VVDRDE---------------EV-VRQVA------------TLASRLG-R---GGLVFAPAGTGEEF-------LESLAEALEKS-GLRVGRFYGNH-NK---RKLLEEFSGGNLDVLVGVASYYGTLVRGLDLPHVVRYAIFAGIPHFKFSI-------KL-ED-VPPLRLLQIASNVRVV-A-SRD------DQAVI-DRLVAYVR-NWL--QNMEPG---EYMALT-Q--------CLS-EGS-----CHE------KYSRLVE-SINHLRSIVEKYLSSKEYLERLSKE-TSL---TVV-SE-------DGQ--LKL-LLPDVLTYIQASGRTSRLYARGVSKGLSIVVT--GN--GLLFEKFAKFSR--LYSSD-IEW------K-----------------PL------------SE------V-------DLDLLVREIDEEREIIRRI-LS-G
>WP_128867476.1 reverse gyrase [Pyrobaculum arsenaticum]
------------------------------------------------------------------------------------------------------------------------------------------------------------------M--VYLHTCPNCGGPITS-DRLVLGLPCREC-LPE-GTK-------------------------AGSIRE----VVAALRRRRVL-------K----GLA-WVD--AYLRGYEGFTEFFKKVV-GFDMWGAQRLWARRLVRGKSFAIVAPTGSGKTTFVLVAALHV-AK-E--------G-K----KALLIFPTSALAHQA---YRKLL-VF----AER-------A-GV---SVR-------------ALAYH-SLL--SDREKK-EVLDAVQR-GEF-D------VLVVTSAFLPKYFDM-L-KA--F-----KFDFVAADDVDSILRATSKNIDRILRLLGVSD--SVLSTA-------LEVINMTK---QLR---KAEV-A----GD------LKE-MER----LSQQ-------I-----------AELRAKLHEEAR--RL--R-LG-IF--IASGAL--AKARRTLRLMLFREILGFDVGGRAE-GLRNVVDLYT----EASG-----------------DV-VEQAV------------ELLKRLG-P---GGIVYVQD---REL-------GMAILERAKAE-GLAVEHFFRP---R---RGVLESFEKGELVALVGLASSRSALVRGIDLPHVIRYVVFVGVPKFRFRV-------RL-EE-FSIPAYLTFLYNVRAV-L-ASD------LRYKA-DRLIGQLK-RLAP---YAL----SVQEAL-K--------KAA-EGA-----ELN-GF----DKHAVE-VVKSAVEFVNSLLEREEIRKAIETS-TEI---RLT-YV-------GGE--LYV-LVPDVTTYIQGSGRTSRLYVGGLSKGLSVMIV--DD--AKVFQALRRELK--LRFDE-AEF------A-----------------HI------------KE------V-------DLDKVLQEIDRDRRIIRDI-IE-G
>WP_012963985.1 reverse gyrase [Hydrogenobacter thermophilus]
--------------------------------------------------------------------------MIK---------------------------------------------------------------------------------------SLLLKLCPNCGGDITA-ERLIKGLPCQNC-MP--D----------------------------E-DKN----LC------EAL-------K--EGSLK-KLC--TALEQVSDWEKLFEKHI-KSKPWSLQVSWAKRVLLGSSFALLAPTGIGKTSFGISMALYL-A--S-------KG-K----KSYIVLPTKLLVKQV---SARLK---------K-------M-GA---DKK------------LLLAFG-DE---EGKKKE-ENKERLTK-GEF-L------ILVSTSMFLYKNYHL-I-P---RD-----ISFVFVDDVDSFLKT-AKNIDKALYLLGFKE--QDVEKA-------MNLIRIK--------------------EK------FKK-TEE----DWEK-------I-----------RELSNEIKS-IS--EK-VK--G-VL--VVSSAT--SNPKSS-RVKLFRELLGFEIGTPTF-YLRNIVDAYA----DY------------------QE---LSLA------------EWIRKLG-K---GGLVFVSSDKGKEE-------VEKLIRELEKA-NISAVSYEDM--D----ESKLSDYERGKVDVIVGIASYRNPLARGFDMPHVVRYAIFYGVPKIVLSL-------QF-E--KNLSHLLWALASIRPY-I-AK--HIKD-YINRV-DDWIVRLK-RYQ---------------------------YIS-DQY-----MED-------KKDLKE-RIEKLREEVKNFLMKEEVLRLLETS-EDI---TLR-FK-------DGD--YQM-VLSDATGYIQASGRTSRMFAGGITKGLSITLI--DD--KRAFNHLKKKVR--WFSED-INF------V-----------------PV------------SS------V-------DLDSLLSQIEEDRKKVKRY-LS-G
>ACB39159.1 reverse gyrase [Pyrobaculum neutrophilum V24Sta]
--------------------------------------------------------------------------MD----------------------------------------LP-------------------------------------------YV--VYLHSCPNCGGPITS-DRLAAGLPCREC-MPK-EPR-------------------------AASLRE----VVEALRRRRAL-------R----ELS-WVA--DYLREYSDFSSFFARVV-GYEMWGAQRLWARRLVRGKSFAVVAPTGSGKTTFVLVSALYM-AG-R--------G-R----RALLIFPTSALAHQA---HRKLL-GF----AER-------A-GL---NVR-------------VVAYH-SLL--GEKERE-EALAAVER-GDF-D------VLVVTSAFLPRRFDL-L-SR--Y-----KFDFVAADDVDSILRATSKNIDRILRLLGVSD--EVLKTA-------LDAINLAK---QLR---KAEV-A----GD------LKE-AER----LERE-------L-----------ASLRAKLQEAVR--GL--K-LG-VF--IASGAL--AKARRTTRLLLFREILGFDVGGRAE-GLRNVVDLYV----EAAH-----------------DV-VQQTI------------DLLRRLG-P---GGIVYVQD---REL-------GMAVAAKAREE-GLAVEHFFRP---R---RGVLERFESGEVAALVGLGSSRSALVRGIDLPHVIRYVVFVGVPKFRFRV-------RL-EE-FSIPAYLTFLYNVRSV-L-AGE------ARYRA-DRLIGQLR-RLAP---YAL----SVQEAL-K--------KAA-EGA-----ELT-GF----DRHAVD-VVKSAVEFVNGLLAREDIRRAIETS-TEV---KLA-YI-------DGE--LYV-LVPDVTTYIQGSGRTSRLYAGGLSKGLSVVVV--DD--QKVFQALRRELK--LRFDE-AEF------K-----------------HI------------NE------V-------DLGAVLEEVDKDRRAIRDI-ME-G
>RLJ00226.1 reverse gyrase [Candidatus Aenigmarchaeota archaeon]
---------------------------------------------------------------------------MR---------------------------------------------------------------------------------------IEYYNFCPVCNGSLGL-KEIKEN----FC-EKK-R-------------------------------------------------------R--------SLYE--EGEEIRKFRKFFKKGF-GSFPRKLQIFWAKRLLRGESFAAVSPPGMGKTSFGCVFSMFL-AD-K--------R-K----RSYIVLPTTLLVKQV---MGRLE-EI----NEK-------F-KK---S-------------VKIACYH-SEM--KGKEKE-WALERIRN-GDF-Q------ILVTTSQFLSRRFRE-I-QE--L-----RFDFIFVDDVDSILKG-SKNVENILRLLDFGR------------------------------------------------------------------------------------------------------K--G-VL--MVSTAT--AK-KG--DIRLFRKFLGFDVGLSFS-SLRNVVDVII----KEKG--------------------IRKLE------------RVLEWIG-G---GGIIYTRS---QEE-------AEKIWKELKSK--YRIGIVISK--E----KKDYEKFVKGEIDYLVGTAFYYGTLVRGLDLPKRIRFCIFYGSPVFRIRLK------DI-R-----ELGYKMIKVLALV-FRNRPE-----------------IK-EFLH----------VLPVID-KP-------------------------------KYQE-TLEKLKGVLEKLIEKGEKGS------DDV---IV------------RK--GEI-IFPDVRTYIQGSGRTSRLFAWGITLGVSFLME--ED--EDMIRGFLKRAG--YY--D-IEF------M-----------------EW------------EA------V-------NWERVKEELEKTRKLM----CK--
>WP_015283500.1 reverse gyrase [Aciduliprofundum sp. MAR08-339]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------VVYGELCPICRGDLTW-EEIENG----RC-FHK-N-------------------------------------------------------T--------PLNKNYLEEKYKKFEEFFLKTL-GSRPRAMQRMWARRVLSGDSFAAIAPTGIGKSLFGIMMAAYL-AS-E--------G-K----KTYIIVPTTLILKEF---VEKLH-SL----GV-----------------------------DDFAHYH-GRM--GRGEKE-EMENRIKR-GDF-K------ILITTTAYLGRRYAT-L-RG--K-----RFHFIFVDDVDSLLKG-SRNLEKILGIM--------------------------------------------------------------------H------------------------------------RK--G-IL--MVSTAT--GT-RGY-NTKILREHLNFDVGNIRN-AVRNVDDITA----PK-----------------------ERLE------------YILNVMG-P---GALIFAPT---AQE-------ARRIASLI-P----RSGIVLAE--S----KESYERFREGELDFLVGVATPYGSLIRGLDMPERVRYVIFYGIPRFKIGLD------DV-D-----ALGERILITVAHL-LREKNP----------------LLR-KAL----------------------------------------------------EKN-DIYEIRVEIKKILQ-RGALQG-----RGF---VY------------RD--GHI-IFPDLKTYIQGSGRASRLYAGGLTKGASFVLD--DP---DLLEILSARAE--IY--G-IEF------S-----------------PI------------DE------I-------DLEKLKEEIDRDRKKV----RE--
>TDA27655.1 reverse gyrase [Archaeoglobi archaeon]
-------------------------------------------------------------------------MVNV---------------------------------------------------------------------------------------LIYENLCPXCGGDLSF-EEIERG----IC-LNK-K-------------------------------------------------------T--------RIC---EESELE-XEKFFEKCV-A-PLREIQRMWAKRILRGXSFSLVAPTGIGKTSFGLAMSLFL-AK-K--------R-K----KSYVIFPTSLLVKQA---VETLK-NF----AGK-------V-GM---EIGLNEVKD-----FSVGFYH-SEV--E---RG-XFFENLHN---F-D------ILITTSQFLAKNFDK-L-EG--L-----KFDFVFVDDVDSVLKA-SRNIERILKLLDLEK-----------------------------------------------------------------------------------------------------KK--S-VL--VVSTAT--AK-VGR-KAELFRRYLNFXIGSSQF-FLRNIEDVIA----NG-----------------------TSIE------------ELLEKLG-D---GGIIYARS---LEE-------CEELKERLRE---FKVGIVTSK--N----LKDFEAFLKGEVKHLIGTAHHYGALVRGLDLPEKIKFAIFTGCPAYRVRVE------DL-E-----KVSPSVLRILVHF-YKDDER-----------------IA-KYVP----------KLRFIE-KI-------------------------------------AGEVRGALKEVMSEREANV------RDA---VV------------RK--GEI-IFPDVRTYIQASGRTSRLTVNGLTKGASFLFE--GD--NQLLNAFIERAK--FF--D-INF------R-----------------DI------------SE------I-------DLDFLRKEIEESR-------KK--
>WP_081225965.1 reverse gyrase [Vulcanisaeta sp. EB80]
--------------------------------------------------------------------------ME--K-------------------------------------QP-------------------------------------------LV--VYRRACPNCGGDITS-DRLGSGLPCHKC-LPE-TPR------------------------KVSGVLE----VLNTLEKLGTL-------N----RLK-ALS--NLLNEYEDFAKMFKDIV-GTNMWGAQRLWARRIIKGKSFAIVAPTGSGKTTFGIVASIYV-AT-R-------RK-G----KVLIVVPTSTLAYDV---SRRLT-EY----VGK-------I-HV---GVR-------------VVHAS-SIL--NKQELV-DAMKAIED-GDF-D------VLIVTNAFLSRHMDL-L-RR--Y-----KFSLIFVDDVDSVLKASSKNIDRLLILLGIDE--DTIRKA-------LTVVDLMK---RLR---KAIRFR----AS------EEE-IDK----LREE-------I-----------KKLSNELSNYVK--NN--N-IG-IL--IASGAL--TRMRRTARLFLFREFLGFETGGRAE-GLRNVVDVYA----KPEG-----------------SL-IDYAV------------QIVKRLG-G---GGIVYVPPDL-KDL-------VNELNDKLTEI-GVKSATYLKP---S---KSVLNDFVEGKLDVLIGLATSRSSLVRGIDLPQRIAYVVFVGVPRMRFKV-------KL-EE-FTPTRYLVFLFNIRNI-V-PQY------LRNDI-DRVIVRLR-NLTA---LNQG---QVNNIL-R--------AIE-EGR-----ELS-GF----DKYAAD-VIKDAVDLVNKLLKDSNIRKAIEES-GEV---GLE-YI-------NGD--LYV-VVPDVTTYIQGSGRTSRLYVGGVSLGLSILLV--DN--DKVFNGLIRNLR--YRLED-VRL------Q-----------------NI------------NE------V-------NLDNVMSKIRSERELIRNI-ML-G
>WP_008286846.1 reverse gyrase [Hydrogenivirga sp. 128-5-R1-1]
--------------------------------------------------------------------------MIS---------------------------------------------------------------------------------------ALFEKLCPNCGGDISS-ERLLKGLPCDSC-LPE-E---------------------------VP-REK----LC------EAL-------R--EGSLK-GLC--DINSLTDRWELFFKEKV-GSDPWSLQRSWAKKVFLKRSFALLAPTGVGKTTFGVVTASFL-V--R-------EG-G----RSYIILPTKLLLEQV---QKKLV---------E-------A-GV---SEE------------ELVVAS-DT---TAKRKK-ETKERISR-GDF-R------VLVTTSMYLYKNFEL-I-P---KD-----FNLIFVDDVDSFLKT-AKNIDKVLYLLGFTE--DEVQRA-------YELVRLK--------------------DK------RNK-TKE----DWEL-------I-----------RRESEEVAR-LS--EK-AR--G-VL--VVSSAT--GNPRSS-RIKLFRELLGFEVGRPTV-YLRNVADLYE----EV------------------DDM-ESALV------------SRVKELG-S---GGLIFVSSDVGREG-------VERVVKLLRKA-KVKAKSYEEV--------KDFSEFEKGKVQVLVGISSYRNPLVRGLDLPHVVRYALFYGVPKITVSL-------SI-E--TSVSHLLWALLSIRPS-V-AK--EIRE-KVREV-DRWIQTLR-RYS---------------------------FIS-EDF-----IER-------TPDLKK-RIENLREEIKKFLLSEEIKSLIENS-EEL---TLR-KS-------EGG--YTI-VVADVTGYLQASGRTSRMFAGGITKGLSYILV--DD--RRALNNLLRKIR--WFNEE-VKF------L-----------------PA------------EE------V-------NLKELLAEIDTDREKVRAI-LE-G
>KUK02857.1 Reverse gyrase 2 [Thermotoga sp. 50_64]
--------------------------------------------------------------------------MIF---------------------------------------------------------------------------------------AVFESLCPNCGGRIDA-ERLEKGLVCEQC-LP--EP--------------------------RE-GD-----LCELLEKR----------Q----LYE-SVC--ELMEKERRFVEFFHLGV-GNPPWSLQKHWAKRIFQGQSFAIVAPTGVGKTTFGAAMACFL-E-------------G----KAYILVPTRALVKQV---KQRCE-SL---------------------SKK------------SVVAYT-GR--------E-SEKEKIRK-GDF-D------ILITTNMFLSRNFDA-L-ED--KR-----FDFIFVDDTDSLLKS-GKNVDKVLKLLGFTQ--QQINLA-------VR-----------------------------------------------------------------------NQLQE--E--PK-PK--G-VL--VVSSAT--LKPKTN-RAILFKKLLGFDVSPVRV-SLRNVLDTYL----HVGN---------------EEEA-LERLV------------EWIRKLG-D---GGFIYVSSRFGKEG-------VDRIVSWLKKH-KIEAVSYEEF---------DPGEFRKKKFKVAVGISVPNNVLVRGLDLPDAVRYAIFFDVPHVSFPM-------RF-E---NENVQRALLMALRYL-V-KDE---------KI-ERYLSLIL-SKR---------------------------GRT-TDT-----S------------------QEIARFLSELLSKEEILKKLKAS-SDV---LIE-EK-------DNE--LFV-NLADVATYVQASGRTSRMFAGGVSRGVSLLIF--WD--EKLFNNLKKRLR--LFFDE-IDF------V-----------------HA------------ED------V-------DWLKEIKRVDEDRVKITKL-AS-T
>WP_013143636.1 reverse gyrase [Staphylothermus hellenicus]
-----------------------------------------------------------------------MVELK-------------------------------------------------------------------------------------HIHGYYRYSCPNCAGENSD-LRLIYKAPCDKC-IEE-ELFD-QIRE-NI-----------SKKSYKEILET----YYKVLQKHNKL------KK----RFE-SLY--KFEEKLEKFEEFFSRATGGYKFWSAQRTWARRLLKRRSFSIIAPTGMGKTMFALISSLYL-SK-KQIMIQKNRA-SRK--KVYLVFPTTPLLLQA---EKKLR-KL----AEQ-------A-RI---PVCQEENHD-Q-TCLNIISIH-GRV--SKKKRE-KLLEEIKS-GNF-D------ILLSTNMFMHRNYEL-L-LG--K-----KYELIVMDDVDAILRS-GKAIRILFYLLGLTD--QEINEA-------IEYLKARQ---RLA----------------FRLS-EEK-RRE----LEQK-------L-----------ETLEKRIEKYKRKIGT-------IV--IVSSAT--GKPRGI-YPRLFRILLNFEAGSKAE-AIRNIVDTYT----YPEE-----------------SI-EQTII------------KLAKKLG-N---GGLIFVPIDKGVEY-------AETIAELLKKN-GINAEAFHAK--KA---VKLLEEFASGNIDILVGVATYYGVMVRGLDLPDRVKYAIFTGVPRHKFST-------RL-ET-PSPTDVLRIFTILRDV-L-EGE------EKRKA-EILIGRIS-LRL--RRLSQG---ALMKLK-E--------DFI-KKL-----QGE-EV---EEYPLLS-MLIEALSMARELLSKPEIWEKLKQK-GDV---ALI-QE-------DGK--SYI-LIPDVATYIQASGRTSRLYPGGITKGLSIVIV--DD--QRLLNGLTKRMR--WLYEE-FDM------R-----------------RL------------DE------V-------DLDNLMKEINEERRKVKMI-LE-G
>WP_068542015.1 reverse gyrase [Thermodesulfatator autotrophicus]
---------------------------------------------------------------------------ML---------------------------------------------------------------------------------------FLVAHACPNCGGTISD-ERLKQGLPCSKC-LPV------------------------------PVEND----ICKVLGEKGQL-------K----RLS-LFC--EALSELEKFRRHFREAI-GFGPSSLQETWIKRLLLRESFAIIAPTGTGKTTFGLLASLYF-P-------------G----RVLILVPTRLLAQQI---GERLE-DF----SKK-------T-GI----SR------------KILVYL-GK--------K-KDKEAFAA-KDF-D------ILVCTTAFFYKHVED-L-L---DI----DFEFVFIDDVDSFLKR-SAHIESLFKLLGFSE--REIALA-------LK---------------------------------LRK-SEK----DFEK-------L-----------EAIRKRH-A--------GK--K-IL--LMSSAT--LKPRTS-RVLLFRYLLGFEVQRAVS-SLRNIVDAYE----DLSTYD-------------FSSL-LEKVA------------ELIKILG-Q---GGLLFLSQSYGKEQ-------VEKAVEFLRTR-GFKVLSYLEL--SP---GELMTQMETGEFDVAVGLAHLANPLVRGIDLPYVLRYALFLGVPKHVIPT-------KV-D--LLPKSLFSVLANIVSI-L-DEE------ERLKA-ISDLQYLR-RYL---------------------------TLT-QEN-----LPR-------YPRILE-RLKEIKAFIENKFKDQAFLERLSKS-EEV---FLK-KE-------GDE--LFL-VIGDTATYIQASGRVSRLTAHGLLKGLSVVLV--ED--RRAFLSLERRLR-FQLGDD-FSF------V-----------------PL------------ET------L-------DLEKLGLELTQVRRREQ----N-T
>EWG08298.1 reverse gyrase [Candidatus Aramenus sulfurataquae]
--------------------------------------------------------------------------MGS------------------------------------DYDIPD---------------------------------------------IIYMGSCPNCGRDVSS-RRLYRGSLCENC-VRD-EREFESLFD-----------------------------LVNYLKNYRTL-------K----QLS-EYK--NILEEYSKVSDLFATIL-GSPPLGPQRSWIIRALKGESFAIIAPPGLGKTTFGILMSLYF-FT-K--------G-I----KSLMIFPTKTLVKQV---VGKIQ-QM----SRD-------F-EK---------------V-PKVSYYI-SGM--TSSQRE-ELNKVLES-SDF-D------IFMSTSRYIINNIDH-L-NTS-------QFGYVFVDDVDSVLKS-SKSSVSVLKLMGFTE--DDVKTV-------KELLWKAR---R-------------------------D--ES----AFGE-------I-----------EKLRKKKVG-----NK-------VA--IFSSAT--IT-KSN---PVFSSLMGFRPGSAVI-YLRNVIDSYVK----------------------GGDV-VDTIR------------RILGKLG-P---GGLVFVPVDKGTAY-------AKQLAEEING--DLSVDFISSSS------TSKLDKFVNGEIDVLIGVATHYGILVRGIDIPWRVKYAVFAGIPKFRFKIG---------EN-MHPLAMLRMLSLISLV-T----------KDQGI-ASVLRQVR-ARL--RNTSPA---ALNVLA-Q--------KVK-EGQ-----ID------------DQ-VLAKAYEIVNENLKKRDVLEKIAEI-GEI---SV-----------TSD--GFI-SSPDYLTYIQASGRTSRIFGGELTTGLSVLLV--DD--EKLFELLTRKLS--LVLDE-VKW------E-----------------PL--------DVVNWK------IGE----ADLAKIVEKLNSERERIKKI-RESG
>RLE77357.1 reverse gyrase [Thermoprotei archaeon]
----------------------------------------------------------------------MEKLAL----------------------------------------------------------------------------------------AIFKKLCPICNGEITS-ERLEQGLPCSKC-LPD-IHDK-NTFK-KIEQ------------------------------------------S----KWG-NLL--NVKNNVITLNNFFKLAL-GSEMWSAQKLWAKRIFQNKSFAIVAPTGSGKTVFGIILSIYL-SM-Q--------G-K----KVLFILPTSILVEQV---SEKAE-AF----IGK-------V-KA--SKIS-------------IAYYH-SFL--TKKQKE-EMLNKIKN-NET-N------FIIVTSNFVSRYHSF-M-VG--K-----KFDLVFVDDVDSILRS-SKIFDKVLEYIGFDK--KTIQSA-------LQIVDLRS---KASK-MRRLGRT-------------RE-AES----YMKM-------I-----------EDLKRNLNKVIK--KR--K-IG-TI--IVSGAS--LRGRRTRRIKLFKELLNFDVGSKTE-YLRNIVDAYV----FASD------------------L-KNEAI------------KLVKKLG-S---GGIIFVPQDKGLGF-------VKELDNAFKEA-GIRSEAYIRP---R---KGILRRFSKGEVDVLIGLTSYKSPLTRGIDLPHVVKYAIFVGVPKFKLSL-------NI-DE-FKPSRMIILLANIRDY-L-DKD------LRYEC-DKRIAKLR-NIV---MLYRE---QLKDII-E--------AIK-AGR-----RLV-NY----EGYAQK-VIISIYDFLKNILSDKEILAKIKES-PTL---RIS-EG-------SGE--ISF-ILADPIAYIQGSGRTSRLYSGGISKGLAVTIV--DD--DKAFKQLSKELS--YRLDD-FKW------Y-----------------DL------------AE------L-------DLDKLIKEISDERVLIKEI-LE-G
>WP_014127851.1 reverse gyrase [Thermoproteus tenax]
--------------------------------------------------------------------------MD----------------------------------------FK-------------------------------------------TIRAIYLHSCPNCGGAVDS-SRLAQGLPCSEC-LPR-ALK-------------------------LENLKS----VIQALKSEGSL-------K----ELA-TLD--EVLRRYEELNVLFEKVV-GFRMWGAQRLWAKRLAAGKSFAVVAPTGSGKTTFLLVSSLYM-AR-G--------G-K-----VLLVFPTSALAYQA---YKKLL-DY----SAR-------A-NY---SGR-------------IISYN-TML--REQERE-EALKRIEE-GDF-D------ILIITSAFLPKYFDV-L-AK--Y-----KFIFIATDDVDSVLRATSKNIERLLRLLGATD--EALNLA-------LDIIELNK---KRA---RQML-G----GD------EKG-LEE----SDVE-------I-----------KRKREELRRLKA--RL--K-LG-VF--IASGAL--AKARRTTRLLLFRELLGFDVGGRAE-GLRNVYDVYA----KLSE-----------------DP-RAQVA------------ALVKRLG-S---GGIIYVQD---KDL-------GRELVEYLKGE-GIKAEHFFRP---R---RKVLEAFERGELDALVGLASARSALVRGIDMPHVIRYVIFVGIPKFKFRV-------KL-DE-FSAPAYLAFLYNVRGV-L-PQE------LKFKA-DRLIAQLR-RIAP---YTA----GLEKVL-T------------EGP-----K-N-SF----EEYLLN-VVKSAVEFVGLILSRDDVKRAIETS-TEV---KLT-YI-------DGQ--LYV-LLPDVTTYIQGSGRTSRLYAGGLSRGLSVILV--DD--EKVLHALRRELE--LRFDE-VKF------Y-----------------DL------------AE------T-------DLDKILREVDSDRETIRRI-LS-G
>WP_007545468.1 reverse gyrase [Sulfurihydrogenibium yellowstonense]
--------------------------------------------------------------------------MIA---------------------------------------------------------------------------------------SIFKNLCPNCSGDITS-ERLYKGFPCDKC-LPQ-E----------------------------P-KED----VC------DVL-------D--KGKFK-KLC--DIDDEVNNWQNFFRKLI-GSHPWSLQITWAKRFFLNRSFALLAPTGIGKTSFGLSIASYI-A--Q-------KD-K----KSYVILPTKLLVNQT---VKKLT-Q-------I-------F-KL---KED------------QILFFG-EE---NKKEKE-AKLERFKD-GDF-S------VLITTSMFLYKNHDK-I-P---KD-----FSLVFVDDVDSFLKT-AKNIDKALYLLGFDE--KDINLA-------LEVIKLK--------------------AK------QNK-TDE----DWNK-------I-----------NQLTEKLRK-IE--AK-RK--G-VL--IVSSAT--SNPKSN-RIKLFRELLGFEVGTPTF-YLRNIIDSYD----DI------------------EN---HELS------------ELIKKLG-K---GGLVFIPSDKKKEY-------TEEVKEYLTKK-GVTAATYEEI--D----DEILKKYENGKIDVLIGISSYRNPLARGIDLPHVIRYAIFYGVPKIVLSL-------KF-E--SNLSHLLWALSSIRAY-I-LK--KFPQ-YAVQI-DKWITQLK-KYQ---------------------------YLT-EEF-----LQN-------NPNLKE-KVDNLRLEVGQFLNSEEIINLLKES-NEV---TLR-KD-------EDG--YKL-VVSDVTGYLQASGRTSRMYSGGITKGLSVILI--DD--KKAFNHLQKRVR--WFSDD-IEF------V-----------------DF------------KS------I-------DLDKILKEIDLDREKVRKI-LK-G
>KJR79590.1 reverse gyrase [Candidatus Aramenus sulfurataquae]
--------------------------------------------------------------------------MGS------------------------------------DYDIPD---------------------------------------------IIYMGSCPNCGRDVSS-RRLYRGSLCENC-VRD-EREFESLFD-----------------------------LVNYLKNYRTL-------K----QLS-EYK--NILEEYSKVSDLFATIL-GSPPLGPQRSWIIRALKGESFAIIAPPGLGKTTFGILMSLYF-FT-K--------G-I----KSLMIFPTKTLVKQV---VGKIQ-QM----SRD-------F-EK---------------V-PKVSYYI-SGM--TSSQRE-ELNKVLES-SDF-D------IFMSTSRYIINNIDH-L-NTS-------QFGYIFVDDVDSVLKS-SKSSVSVLKLMGFTE--DDVKTV-------KELLWKAR---R-------------------------D--ES----AFGE-------I-----------EKLRKKKVG-----NK-------VA--IFSSAT--IT-KSN---PVFSSLMGFRPGSAVI-YLRNVIDSYVK----------------------GGDV-VDTIR------------RILGKLG-P---GGLVFVPVDKGTAY-------AKQLAEEING--DLSVDFISSSS------TSKLDKFVNGEIDVLIGVATHYGILVRGIDIPWRVKYAVFAGIPKFRFKIG---------EN-IHPLAMLRMLSLISLV-T----------KDQGI-ASVLRQVR-ARL--RNTSPA---ALNVLA-Q--------KVK-EGQ-----ID------------DQ-VLAKAYEIVNENLKKRDILEKIAEI-GEI---SV-----------TSD--GFI-SSPDYLTYIQASGRTSRIFGGELTTGLSVLLV--DD--EKLFELLTRKLS--LVLDE-VKW------E-----------------PL--------DVVNWK------IGE----ADLAKIVEKLNSERERIKKI-RESG
>RLI07360.1 reverse gyrase [Candidatus Bathyarchaeota archaeon]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------VAYEALCPHCHGDLRG-EEIEEG----HC-QVT-H-------------------------------------------------------R--------PLHDAYKRGEEGEFEDFFRRIV-G-EPRELQRFWMRRLLMGESFTAVAPTGIGKTTFGLAYALFN-AL-R--------G-R----RSYLIVPTTVLVDQC---IQTLR-EF----CGR-------L-GV---KLGLNDEGE-----VSAAYYH-TGM--GRGERK-RFEEALRR-AG---------ILITTSQFLSRNFHL-L-ED--L-----DFDFIFIDDVDAILKA-SRNVERVLRLLGLER----------------------------------------------------N-GDE----WSGK------------------------------------PR--G-VL--MVSTAT--AR-RGR-AARLFREVLGLDIGSSTY-TLRNIEDYVA----GAPN--------------------IGEVK------------RILRTLG-R---GCLLYART---IDE-------ARKFQEQLSDE--FRVGLVVSG--D----QGDLERFQRGELDHLIGTAHFYGLLVRGLDLPELVRYVIFLGAPIQRVRIE------EL---------TPRMVKILAII-MREDEE-----------------IR-RYIG----------RIWDIE-R---------------------------------RPA-ELEELRSLIAERLREGRV--------EDI---VY------------RE--GEV-IFPDLRTYIQGSGRASRLTAWGLTKGVSILFE--ED--AEILEAFKRRGE--YY--D-IDF------K-----------------PL------------SE------A-------DLEALSREIDESR-----------
>RLE76844.1 reverse gyrase [Thermoprotei archaeon]
----------------------------------------------------------------------MEKLAL----------------------------------------------------------------------------------------AIFKKLCPICNGEITS-ERLEQGLPCSKC-LPD-IHDK-NTFK-KIEQ------------------------------------------S----KWG-NLL--NVKNNVITLNNFFKLAL-GSEMWSAQKLWAKRIFQNKSFAIVAPTGSGKTVFGIILSIYL-SM-Q--------G-K----KILFILPTSILVEQV---SEKAE-AF----IGK-------V-KA--SKIS-------------IAYYH-SFL--TKKQKE-EMLNKIKN-NET-N------FIIVTSNFVSRYHSF-M-VG--K-----KFDLVFVDDVDSILRS-SKIFDKVLEYIGFDK--KTIQSA-------LQIVDLRS---KVSK-MRRLGRT-------------RE-AES----YMKM-------I-----------EDLKRNLNKVIK--KR--K-IG-TI--IVSGAS--LRGRRTRRIKLFKELLNFDVGSKTE-YLRNIVDAYV----FASD------------------L-KNEAI------------KLVKKLG-S---GGIIFVPQDKGLGF-------VKELDNAFKEA-GIRSEAYIRP---R---KGILKRFSKGEVDVLIGLTSYKSPLTRGIDLPHVVKYAIFVGVPKFKLSL-------NI-DE-FKPSRMIILLANIRDY-L-DKD------LRYEC-DKRIAKLR-NIV---MLYRE---QLKDII-E--------AIK-AGR-----RLV-NY----EGYAQK-VIISIYDFLKNILSDKEILAKIKES-PTL---RIS-EG-------SGE--ISF-ILADPIAYIQGSGRTSRLYSGGISKGLAVTIV--DD--DKAFKQLSKELS--YRLDD-FKW------Y-----------------HL------------AE------L-------DLDKLIKEISDERVLIKEI-LE-G
>ABO08118.1 Reverse gyrase [Pyrobaculum calidifontis JCM 11548]
--------------------------------------------------------------------------MD----------------------------------------IP-------------------------------------------LV--VYLHSCPNCGGPVTS-DRLAGGLPCREC-LPE-VVK-------------------------AGGIAD----VVRALRRRRAL-------K----GLA-WVD--EYLRRYEEFSSLFKAAV-GFEMWGAQRLWARRFVRGRSFAIVAPTGSGKTTFILVATLYA-AR-E--------G-K----RALLIFPTSALARQV---HQRLL-SY----AEK-------A-GV---SVR-------------AVAYH-SLL--TEKEKK-EALGAVEG-GDF-D------VLIVTSAFLPRYFDL-L-KR--F-----KFDFVAADDVDSILRATSKNIDRILRLLGVSD--EVLKLA-------LDVINAVK---ELR---KAEI-A----GD------LKE-VER----LDAE-------V-----------TALRAKLQEEAR--RL--K-LG-IF--VASGAL--ARARRTTRLLLFREILGFDVGGRAE-GLRNVVDVYV----EQGK-----------------DV-VGQVV------------ELLKRLG-P---GGIVYVQD---REL-------GLAIVERAVGE-SLAVEHFLRP---R---RGVLERFERGELAALVGLASARSALVRGIDLPHVIRYVVFVGVPKYKFRV-------RL-EE-FSIPAYLTFFYNVRAV-L-SGE------LRYKV-DRAIGQLK-RLAP---YAL----SVQEAL-K--------KAA-EGQ-----ELS-SF----EKHAVD-VAKGAVELANSILSDEELRRAIDSS-TEV---RLA-YI-------GGE--LYV-LVPDVTTYIQGSGRTSRLYAGGLSKGLSVVVV--DD--WKVFTALQRELK--LRFDE-AEF------K-----------------RL------------DE------V-------DLSAVLAEVDRDRRTIREI-ME-G
>TDA32549.1 reverse gyrase [Hadesarchaea archaeon]
-------------------------------------ME--------------------------------GL-LG----------------------------------------------------------------------------------------ATYKGMCPNCGGDIKD-SELVNRGVCYRC-F----------------------------------------------SPNGRG-------LARPGKYA-EVL--RMEEEVEEFCKFFAMLM-GSKPWALQEVWARRVLLKRSFSLVAPTGIGKTHFGLVMALYL-AQ-K--------G-K----RSYIVVPTSLLVKHL---LDRAE-EL----LKR-------A-G----KAAV------------VLGYY-SGM----PEGE-GVLEKIRE-GEF-S------VLITTDRFLYTKFDL-F-HS--L-----NFDFIFVDDVDSFLKS-PKNIDKVAFLLGFSS--EEVEKA-------LS-----D---EPV---EG-----------------------------------------------------------------R--R-ER-VL--VVSGAT--LKGKRTKRLRVFRKLLGFEPGFTLE-FVRNIANFA-----LRPKRK----------------V-EEEVA------------DLVKKYG-P---GCLVFVPQAKGLEY-------AEKIAETLEKE-GMSVFLYERM---S---PGMLEKFRKGEYAVLVGIASSRSPLARGLDLPETVRYVVFAGVPRREMKV-------EV-KE-CNPQKLLVALKALSPL-L-GER------MGKRM-ASVLSSLS-KVIP---VRGE---LIQKLR-E--------ADE-GKT-----QLE-GF----AAHLRK-VVLEAREILEEAMG-DEELRKEVGR-LDV---EMR-ME-------EGE--WVF-ISPDTDGYLQASGRASRFYAMGISRGVSIVVV--DD--EKAFSGLSRRLR--LLADE--EF------E-----------------EY------------VP------E-------KVKEEFEKVDRDRETIRRI-RK-G
>WP_052846290.1 reverse gyrase [Sulfurisphaera tokodaii]
-----------------------------------------------------------------------------------------------------------------MNTIPS---------------------------------------------SNYLSSCPNCGRVISA-ERLYKGSVCSEC-LEE-DREFNSIRE-----------------------------LVNELSRLNKL-------N----RLN-YIK--EVLREYDIFVELFKRII-GFPPFGPQKSWIIRVLRKESFAIIAPPGLGKTTFGIITSLYF-SS-K--------N-F----RSILIFPTRSLVKQA---VDRIS-MY----SNK-------T-NI---------------E-TKLLYYH-SGI--NESQKQ-ELYKALNA-GDF-N------IFIATNRFFIDKINE-L-KNI-------KYDFMFVDDVDTALKS-SKSAETILNLAGFSK--DDILSV-------KELLRKSR---E-------------------------D--ES----VYTK-------I-----------QEIRGNKLK-----GK-------TI--VFSSAT--LT-RGN---PVLSALMGFRPGSSVI-YLRKIIDTYAY---LPN---------------NDDDV-VNLLK------------ELLNKLG-E---GGLIFVPVDKGQEY-------AKFLEAKLSD--SFNVVTITSSN------TNKIEDFANGNIYALIGSATHYGILVRGIDIPWRVKYAIFVGIPKFKFKIG---------EV-MNLVALSRILSMIGLI-T----------KDQDI-VRLAGRVR-GKL--RKLSPA---AISMLT-N--------QAR-EGK-----LE------------DE-TLLRAYEVVNKYLEDKDILKKIAEL-GDL---VI-----------S-N--GYI-LMPDYLTYIQASGRTSRIYGGELTTGLSVLLI--DD--INLFNILNRKLS--LILDE-IIW------Q-----------------EL--------QIKKNK------IGS----SDLTEIINKINEERERILKV-KKEG
>WP_121010374.1 reverse gyrase [Hydrogenivirga caldilitoris]
--------------------------------------------------------------------------MIS---------------------------------------------------------------------------------------AVFENLCPNCGGRISS-DRVLKGLPCDKC-LPK-E---------------------------VS-RDK----LC------SVI-------K--KGSMR-ELC--DIEEKVNRWELFFRENV-GSTPWSLQRSWAKKVFLKRSFALLAPTGVGKTTFGVTVAAFL-A--K-------EG-K----KSYIILPTKLLLEQV---QKSLI---------K-------A-GV---PEG------------ELLVAG-EV---TEKKKR-EAKEKIAG-GDF-K------VLVTTSMYLYKNYEL-I-P---RE-----FDFIFVDDVDSFLKT-AKNIDKVLYLLGFSE--EEVQRA-------YELVRLK--------------------EK------RNK-SKE----DWEL-------I-----------KEESQKIAE-LS--SK-AR--G-VL--VVSSAT--GNPRSN-RIKLFKELLGFEVGRPTV-YLRNVADVYE----EP------------------EDM-DRALV------------EKVRELG-G---GGLIFVSSDLGKEG-------VNRVLKLLKKE-KIKAKSYEEL--------KDFSEFEKGKVQVLIGISSYRNPLVRGLDLPHVVRYALFYGVPKITVSL-------NI-E--TSVSHLLWALLSIRPT-I-AK--SLKD-KVKDV-DRWIQTLR-RYS---------------------------FIS-ESF-----IEQ-------SPELGK-RIESLRKEVQKFLLSKEVKKLLESS-EEL---TLR-KT-------EEG--YTM-VVADVTGYLQASGRTSRMFAGGVTKGLSYILV--DD--RRALNNLFRKVR--WFNED-VRF------V-----------------PA------------TE------I-------KLEELLKEINEDRRKVKAL-LE-G
>HAA82696.1 reverse gyrase [Thermotoga naphthophila]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>TDA25490.1 reverse gyrase, partial [Archaeoglobi archaeon]
---------------------------------------------------------------------------ME---------------------------------------------------------------------------------------IIYEKLCPVCTGDLTT-EEINSK----FC-AVR-N-------------------------------------------------------V--------LFC---ENKELEPFIEFFRRCI-G-EPRDIQKMWAKRILRGESFTLTAPTGIGKTSFGLAISLYL-AN-N--------G-K----RCYIIFPTSILVRQA---VENLK-SY----AEK-------T-GI---ELSFNDTEK-----LPVGFYH-SDI--E--AKD-VFFEKIKD---F-R------ILITTAQFLAKNFEK-M-KE--I-----TFDLIFVDDVDAVLKA-SKNVERILTLLGIGK--D-------------------------------------------------------------D------------------------------------KK--G-VL--VVSTAT--AK-PGK-NAELFRKFLNFTIGSSQF-YLRNIEDVTF----DD----------------------WRQLP------------KLLEKLG-P---GGLIYART---VDE-------CEKVYEYLKDR--FRIGIVTSK--D----SKDFELFSKGELDYLVGTAHYYGLLVRGIDMPERIRFAVFLGSPVLKFRVE------DI-E-----TASINTIRALALI-LKEDKR-----------------VE-KFIP----------KLKAIR-RV-------------------------------------EKELRETLKQVIAEGNLIV------KDA---VI------------RR--GEV-ILPDLRTYLQASGRTSRLHAGGITKGASFLYE--GD--SEVLHAFLTRAR--YY--D-ISF------K-----------------TL------------NE------V-------DLEKLRHEIDESR-------SK--
>AET33892.1 reverse gyrase [Pyrobaculum ferrireducens]
--------------------------------------------------------------------------MD----------------------------------------IP-------------------------------------------LV--VYLHSCPNCGGPITS-DRLALGLPCREC-LPE-GSK-------------------------AASIRE----VVAALRRRRAL-------R----GLA-WVD--AYLRSYEEFSAFFKEVV-GFEMWGAQRLWARRLVRGKSFAIMAPTGSGKTTFILVATLYL-AG-G--------G-R----RALLIFPTSALAHQA---HKKLT-AF----AER-------A-GR---RVK-------------ALAYH-SLL--TEQERR-EVLEALER-GDF-D------VLVTTSAFLPRRFDL-L-SR--Y-----KFDFVAADDVDSILRATSKNIDRILRLLGVSD--SVLNAA-------LEVINLAK---QMR---KAEV-A----GD------LKE-VER----LDQQ-------I-----------ASLRARLREEVG--KL--K-LG-VF--VASGAL--AKARRTVRLLLFREILGFDVGGRAE-GLRNVVDLYA----EAGG-----------------DL-AGQVV------------ELLKRLG-P---GGIVYVQD---REL-------GETIAERAREA-GIAVETFFRP---R---RGVLERFERGELAALVGLASSRSALVRGIDLPHVIRYVVFAGVPKFKFRV-------RL-EE-FSIPAYLTFLYNVRSV-L-SGD------LRYRA-DRLIGQLK-RLAP---YTL----SVQEAL-R--------KAA-EGG-----ELS-SF----DRHSVE-VVKSAVEFVGDLLRREEIRRTVETS-TEV---KLA-YI-------NGE--MYV-LVPDVTTYIQGSGRTSRLYAGGLSKGLSVVLV--DD--AKVFHALRRELK--LRFDE-AEF------R-----------------RL------------DE------V-------DLGKVLEEVDRDRRAIRDI-IE-G
>WP_009073776.1 reverse gyrase [Metallosphaera yellowstonensis]
---------------------------------------------------------------------------MG------------------------------------NEGVPP---------------------------------------------VIYMSLCPNCGSNISS-LRLMSGLACERC-LPE-DVRVNGLEE-----------------------------LVRSLKERGTL-------K----HLS-SVE--RLLAEFKAVSDIFRTAV-GSEPMGPQRSWIVRALRGESFAIIAPPGLGKTTFGIIMSLYF-SS-I--------S-K----KSLMIFPTKTLVGQV---VQKIQ-EM----SKN-------M-ER---------------P-PLLSYYL-SGM--NQSKRD-EMDKTLSS-GDF-D------IFVSTSRYVIDHIDE-L-SRL-------EYNYLFVDDVDAVLKS-GKSSVTILKLMGFSP--QDIDRT-------KELLKSAR---EG------------------------D--TS----VFDE-------I-----------KKIRENSLK-----DR-------VA--IFSSAT--IT-RSN---PVFTSLMGFRPGSTLI-YLRNVVDSYLI----------------------SKDT-FTPSV------------ELVKRLG-P---GGLVFVPVDKGTQY-------AQELASELNK--WMKASAITSSN------SRKLEEFESGQIDVLVGVATHYGLLVRGIDIPWRVRYAIFAGIPKFRFRLG---------EV-MHPLAMLRVLTLLSLV-L----------KDQEV-SRVLRIVR-ARL--RRTSPA---ALVMLA-K--------SIR-EGT-----IS------------DQ-YFIKAYEIVNKYLQDISILNKIAQL-GDL---SI-----------SDG---TI-SIPDYLTYVQASGRTSRLYGSRLTTGLSIVIV--DD--ETLFEQLKKKLS--LVLDE-IRW------H-----------------PL--------DLVQWR------IGE----TRVDDLMRKINEEREEITER-KR-S
>RLG71086.1 reverse gyrase, partial [Thermoprotei archaeon]
--------------------------------------------------------------------MVFE--IH----------------------------------------------------------------------------------------GIYRHGCINCGEEISD-LRLGYMLPCEKC-LPI-H-VE-DLKN----------------IVKTPSYIT----TIELTEKLGKL-------K----RLK-KLK--YILEEIEEFNKLFRKLI-GNVMWSAQETWAKRILKNESFSIVAPTGVGKTVFGIIASIYF-AK-K--------N-K----KSYIVVPTTPLVIQV---YNRLM-EF----VGK-------L-NE---PIR-------------VLSYH-AKL--SRKERK-NILEKIAN-SEF-D------ILVTTSKFLSTHFEE-L-KN--N-----KFHFIFIDDVDAILKS-SKNIDRVLMLLGFTE--SDIQIA-------FELIKLKR---RLA--QKTLSNQ-------ER---TKL-LRE----VN-K-------L-----------RRHVEYASR--K------A-KG-VL--IVSSAT--GRPRGL-RVRLFRELLGFEVGTRSE-YLRAIVDTYL----KPDK-----------------SI-EEEIA------------SIVKVLG-K---GGLIFVPTDKGTEY-------AEELASFLRDK-GIRAKVFVSK---E---IKALEEFIRGEVDVLVGVATYYGVMVRGLDLPEIIRYAIFAGIPRFKFST-------KL-DE-PHPLNIMRALVILREV-LEKEE------DKEKV-DRLIIRMK-RFI--AIAPAA---VVSEIA-R--------KLK-ENI-----PPE--------TAAEK-MFYEALAIARSLLEKPEIKMKLKEL-KEI---AIV-EE-------NGK--MFI-LIPDIMTYIQASGRTSRMFVGGITKGLSVVIV--DD--ERLLYGLLRRTK--WFIED-IEW------F-----------------DF------------KA------I-------DLEKLLREIDEDRELVKAV-RA-G
>RLE65836.1 reverse gyrase [Thermoprotei archaeon]
-------------------------------------MRHFS------------------------IRLTSGSLAI----------------------------------------------------------------------------------------AVFKRLCPVCGGEISS-ERLKAGMPCIKC-LPE-NSDTHSILK-NVTS------------------------------------------S----EWG-RLV--SIGRKVEELDTFFKESI-GSRMWSAQKLWAKRVFLNKSFAIIAPTGSGKTVFGILLSLYL-AS-R--------G-K----KVLFVLPTSILVEQV---SEKAE-NF----KDK-------V-GL--SHIE-------------LAYYH-SFL--SKKNKE-KMLATIKN-GKT-S------LIIVTSNFISRYSSL-L-SG--K-----KFDLVFVDDVDSILRS-SKIFDKILTYIGFDD--KTINLA-------LKLLDAKT---SLNK-ARRLGLE-------------EE-VKK----NSKK-------V-----------DKLTKKLKNKLK--NR--K-TG-IL--IVSGAS--LRGRRTKRVKLFRELLGFDVGSKTE-YLRNIVDVYV----NSPD------------------I-EGEIV------------RLVKKLG-P---GGIIFVPQDKGLEY-------VRRIDEILKKA-GIRSEAYLKP---R---KGILKRFSSGESDVLVGIASYRSPLTRGIDLPQVIKYVIFAGVPKFKISL-------NI-DD-FKPSRMIILLANLRDF-L-DKK------TRYEC-DRYIVKLR-NLV---MLYKE---SLDRII-D--------AIK-TGK-----KLE-GF----EGYAQK-IILSIYDFLNRVLSDREVIEKIKSE-ASL---KIT-ID-------DDG--IWF-ILADPIAYIQGSGRTSRLYSGGISKGLAITVI--DD--NKAFKQLNEELS--NRLND-FEW------K-----------------NI------------KE------L-------DLNGLIKEISKERELIKAI-LE-E
>WP_012991133.1 reverse gyrase [Thermocrinis albus]
--------------------------------------------------------------------------MIG---------------------------------------------------------------------------------------AVFKNLCPNCGGDIGA-DRLQRGLPCERC-MP--Q----------------------------E-GDP-----C------HLL-------T--EGQLR-IWC--DVEKKEEDWEKHFERCV-GSKPWSLQKTWAKRVFMGHSFALLAPTGVGKTSFGLAMASFL-A--K-------EG-K----RSYIILPTRILVEQV---VHKLQ-E-------R-------F-RL---KEE------------DLLYFG-DD---SKKQKE-EKRERLKE-GRF-K------VLVTTSMFLYRNYQD-I-P---SG-----FSFIFVDDVDSFLKT-AKNVDKALYLLGFSE--EDIDLA-------MRVIQLK--------------------TK------RQK-TDE----DWEK-------I-----------KEISQKLME-----KR-GE--G-VL--VVSSAT--SNPRSN-RVKLFRELLGFEVGTPTF-YLRNVVDA-------Y------------------QEG-THNFL------------DWVKRLG-G---GGLLFVSSDKGKEE-------VDRVVNILRGE-GISAVSYEEL--K----EETLKDFEEGKIQLLVGIASYRNPLARGLDLPHVIRYALFLGVPKIVISL-------KF-E--TNLSHLLWALSSIRSY-I-VK--KLPQ-HMQKV-DNWISQLR-RYQ---------------------------YLT-EEF-----VEE-------RPDLKE-RLDQLRSQIGEFLSSEELVRIMSES-EEI---TLR-KT-------EEG--YQL-VVSDATGYLQASGRTSRMYAGGVTKGFSLIFV--DD--KKAFHHLVKKVR--WFSDD-INF------L-----------------PV------------EG------L-------DVEKIMEEVDADRSNVRAF-MK-G
>GBC70539.1 Reverse gyrase [archaeon HR02]
-------------------------------------MSQ--------------------------AILNIGLDLK----------------------------------------------------------------------------------------SVYVSLCPNCDGEITD-EELVELGVCSQC-L-----IE---------------------G----------------LQEGGRL-------RIRPGKYS-PVL--ELEERFKEFEAFFERIV-GSRPWSLQRTWARRVLLGRSFSLISPTGTGKTTFCLAMALYQ-AT-K--------G-K----KSYIVVPTSLLVQHL---LERAA-AL----AST-------M-GE---KKPR------------ILGYY-SGM--KRSDAS-QVLQQIAQ-DNF-D------ILITTDRFLYSRYDL-L-SG--K-----KFSFIFVDDVDSFLKS-PKNIDKILLLMGFTL--EEIGKY-------LELIS--G---ESG---EA---G-------------SD-------------------------------NHYKASISS--D--RK--V-DS-VL--LVSGAT--MRGRKTKRMRLFRLALSFEPGSSID-LVRNVSNMY-----LRQGTS----------------L-WEDVA------------GLIERHG-G---GCLVFVPQVAGVES-------AKQLAKYLNTR-GIKAYAYERM---N---ARMLERFRSGEYDVLVGVASTRSPLARGIDLPERIRYVIFAGVPRRELNV-------SW-SE-HRPSMLLSVLRNIAPI-I-REK------KEADL-VQVMGMLN-KCVP---TRGD---ILEAVR-Q--------GLE-TGK-----PPE-GF----AGYVYS-AVTRAHQLLKSSIG-EEELRRIADM-LDL---KIR-AD-------KEG--ISI-LIPDIDGYVQASGRSSRMFAGGITRGISILIV--DD--EKAFRGISRGLE--ALYEE--TF------Q-----------------EY------------QP------E-------LAEEEFKLCDKDRKLLQAI-RI-G
>WP_125672750.1 reverse gyrase [Candidatus Methanodesulfokores washburnensis]
------------------------------------MLLKFLIL------------------RGGFYIGRRPIPVLK---------------------------------------------------------------------------------------AKFLGLCPGCNEDLYT-YAESC-----KC-TLS-S-------------------------------------------------------D--------LME---DLRRAEEFMEFFRKCT-GFEASEIQKVWARRLVRGESFAAIAPTGTGKTVLGIVSSLFF-AR-N----------S----KSYLIFPTLLLVNQA---EDLSK-KF----SER-------A-GL---N-------------LEILSYA-SG-------RR-DILDSISK-GEF-D------VLITTNQFLARNFDL-I-KD--K-----KFGFIFVDDVDSMMKA-SRNLEKVLLLLGFSQ--EEIREK------------------------------------------------I----PAEG------------------------------------EK--G-II--FMASAT--GK-AGK-KTSLLRYLLNFDVGAIREGKLRNVVDISV----NKKE--------------------TGSLI------------DIIRKMGRK---GGLIFLRR---MEE-------AERVAELLENE-GISAEIARGS--D----PDMLERFRKGETDVLIGAAKPYGVLVRGIDIPE-VRYTVFYGAPMYEISIS------NL-EE-ISPGVLSIALASLSGI-LGREAL----------------VLS-RQLK----------L------NP--------------------------------DEE-KIRRAKEILSDFLSSSPKIENVL-------------FR-------DGE--AFL-CIPDMLTYIQGSGRSSRLRPGGLTKGASFLME--DE----LLDFFVRRAS--AY--D-IDF------V-----------------DI------------GS------V-------DLSSLRKEIDEDRA------RK--
>WP_012460317.1 reverse gyrase [Sulfurihydrogenibium sp. YO3AOP1]
--------------------------------------------------------------------------MIA---------------------------------------------------------------------------------------SIFKNLCPNCGGDITS-ERLYKGLPCDRC-LPQ-E----------------------------P-KEE----VC------DVL-------K--KGKFK-ILC--DIDDEVSNWQNFFSKHI-GSHPWSLQITWAKRFFLNCSFALLAPTGIGKTSFGLSVASYL-T--Q-------KN-K----KSYIILPTKLLVNQT---VKKLT-Q-------I-------F-KL---KED------------QILFFG-EE---NKKEKE-AKLERLKD-GDF-S------VLITTSMFLYKNHDK-I-P---KD-----FSLVFVDDVDSFLKT-AKNIDKALYLLGFDE--KDINLA-------LEVIKLK--------------------AK------QNK-TDE----DWNK-------I-----------NQLTEKLRK-IE--AK-RK--G-VL--IVSSAT--SNPKSN-RIKLFRELLGFEVGTPTF-YLRNIVDSYD----DI------------------EN---HELS------------ELIKKLG-K---GGLVFIPSDKKKEY-------VEEVKEYLTKK-GVKAATYEEI--D----DEILKKYENGKIDVLIGISSYRNPLARGIDLPHVIRYAIFYGVPKIVLSL-------KF-E--ANLSHLLWALSSIRAY-I-LK--KFPQ-YAIQI-DKWITQLK-KYQ---------------------------YLT-EEF-----LQN-------NPNLKE-KVDNLRLEVGQFLNSEEIINLLKES-NEV---TLR-KD-------EDG--YKL-VVSDVTGYLQASGRTSRMYSGGITKGLSVILI--DD--KKAFNHLQKRVR--WFSDD-IEF------V-----------------DF------------KS------I-------DLAKILKEIDSDREKVRKI-LK-G
>WP_013680298.1 reverse gyrase [Thermoproteus uzoniensis]
--------------------------------------------------------------------------MD----------------------------------------FR-------------------------------------------VLPALYLHSCPNCGGAVES-YRLAEGLPCSEC-LPE-EVA-------------------------GSDIRR----VIENLRRRNAL-------R----GLA-PLA--DVLRRYEEIANLFEKVV-GFRMWGAQRLWARRLAAGKSFAVVAPTGSGKTTFLLISALYM-TS-R--------G-K-----ALLVFPTSALAYQA---YKKLL-DY----SSR-------A-GL---APR-------------IVTYN-TML--KPQERE-EALKRIEA-GDF-D------ILVITSAFLPKYFEL-L-AR--H-----KFAFVATDDVDSVLRATSKNIERLLKLLGATD--EVLGKA-------FELIELGK---KRG---KAVL-A----GD------EKE-AER----IERE-------I-----------EKAREELRRIKA--EL--R-LG-VF--VASGAL--AKARRTARLLLFREILGFDVGGRAE-GLRNVYDLYV----KMAE-----------------DP-KTQVA------------ELVKRLG-G---GGIIYVLD---KDF-------GKDLVQHLQAS-GIKAEHFFRP---R---RKVLEAFEQGQLSVLVGLASPRSALVRGIDLPHVIRYVVFVGIPKYKFRV-------KL-DE-FSVPAFLSFLYNVRAI-L-PQD------LRFRA-DRLIAQLR-RIAP---YSA----RLDKIL-K------------EGA-----S-N-SF----EEYVLG-VAKSAVEFVASLLSRDDIRKAIEAS-TEI---KLT-YI-------GEQ--LYV-LLPDVTTYIQGSGRTSRLYAGGLSRGLSVVLV--DD--EKVLNALIREME--LRFDD-VRF------E-----------------EL------------SK------A-------DLDGILKSVDEDRENIRRI-LS-G
>WP_117354922.1 reverse gyrase [Acidilobus sp. 7A]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------MCPNCGREITA-DRLEKGLPCKEC-LPT-EINTNDVI-------------------------E----IGLELSRRGNL-------K----GYN-FLY--IMERDFREFSKFFEEKY-GFKLSSAQRSWARRLLSNESFSIVAPTGVGKTTLLMAYAAFM-SS-K-------RG-Q----KVIYIVPTENLVVQT---AERLS-LM----LGD-------G----------------------VVFYY-SSM--PKGQRD-EMLERIKG-GKF-S------VTVITPGFMTRNFDV-L-KA--SA----PFDIMVVDDVDSLLRN-SKNIDRALMLIGFDE--ETIQTA-------LKVVQERL---ELA--ALEASGRG-----------EER-IKQ----LQGD-------I-----------SSLTLKITEKVLE----GH-KG-QL--VIASAT--GRPKGI-KHLIFRELLGFEVGGGTD-YLRNVIDSYI----VTSNV-------------------VGTAV------------EVVRKLG-K---GGIIFVSQALGKAY-------VKELVARLSES-NVRAVQALTNS------RRAVEKLASGEADVAIGVASRYGTLVRGLDLPEVIRYAVFLGTPAIRVELGT-----AL----LSPRRLLRALLFLE-----ER-------------DQSFKGYR-EKL--EGLLKSYNVDSNVVA---------AAIR-GQL-----EAR-GRLEELKELVLE-ASAKAAQALSGMLSEDG--QVLRIG-T-M---VL--RR------EGDK--VWL-YSPDAPSYLQASGRTSRLFRGAMTKGLSVVID--SI--KDLIDAMQDRLR--WMSQA-S-F------V-----------------EF------------SS------L-------KLDEVMHDIEESRKE------T-G
>ABU81698.1 Reverse gyrase [Ignicoccus hospitalis KIN4/I]
--------------------------------------------------------------------------MY----------------------------------------------------------------------------------------ASYRRSCPSCGGEIED-VNLSLGLPCDKC-LRV-VGLE-SLKL-----------D----PSKKDSPSV----RRRLIELGGPL----G-----------ESL--KLEEELESLEKVFQEVL-GAPMWSAQRAWALRALRGESFSIVAPTGMGKSTLGALLSVYL-SH-K--------K-K---KKSYIIVPTTPLVDMM---FRKVS-AF----AEA-------F-GV------------------RAVYFH-SKM--SPSQRK-EMKERLLS-GDF-D------VLITTSRFLINNLDL-L-KN--Y-----EFGFVFVDDVDSVLKS-PKNVDRILMVLGLQE--SDVKRL-------EEVDKELS---RKA---QVLTKL----QD------LQK-RYQ----LLKE-------M-----------RELEEELEDLKR------K-VKGNL--IVSSAT--GRAKGN-RVRLFTRLLGFTPGGVGE-GVRNVVDSYSR---------------------------SSDVV------------EVVKKLG-K---GGLVFVPADLGAKG-------AEEVAEALRAA-GVAAEVATSE---R---IGVIKDFEEGRVEVLVGVATHYGVLVRGIDLPHVVRYAVFVGVPRFKFKL-------KL-EE-PSPMTIYRLCSLAARF-F------------EEC-ASLYAKLR-KWV--QRLGPA---GLQSVE-E--------ALK-EGS--------------ASTPASK-DFMEAYTKLKEIIEKTDFIEKLKES-GEV---DVV-AE--------DS--LYV-LIPDAATYLQASGRTSRLYAGGVTKGLSVVLV--DS--EPLFRGLKKRLA--WVVEE---W------K-----------------EF------------ES------L-------NLSELLKEIDEDRKKVLKV-IR-G
>WP_083756884.1 reverse gyrase [Ignicoccus hospitalis]
-------------------------------------MRPFEK-------------------PLSRLRRRGAEGLY----------------------------------------------------------------------------------------ASYRRSCPSCGGEIED-VNLSLGLPCDKC-LRV-VGLE-SLKL-----------D----PSKKDSPSV----RRRLIELGGPL----G-----------ESL--KLEEELESLEKVFQEVL-GAPMWSAQRAWALRALRGESFSIVAPTGMGKSTLGALLSVYL-SH-K--------K-K---KKSYIIVPTTPLVDMM---FRKVS-AF----AEA-------F-GV------------------RAVYFH-SKM--SPSQRK-EMKERLLS-GDF-D------VLITTSRFLINNLDL-L-KN--Y-----EFGFVFVDDVDSVLKS-PKNVDRILMVLGLQE--SDVKRL-------EEVDKELS---RKA---QVLTKL----QD------LQK-RYQ----LLKE-------M-----------RELEEELEDLKR------K-VKGNL--IVSSAT--GRAKGN-RVRLFTRLLGFTPGGVGE-GVRNVVDSYSR---------------------------SSDVV------------EVVKKLG-K---GGLVFVPADLGAKG-------AEEVAEALRAA-GVAAEVATSE---R---IGVIKDFEEGRVEVLVGVATHYGVLVRGIDLPHVVRYAVFVGVPRFKFKL-------KL-EE-PSPMTIYRLCSLAARF-F------------EEC-ASLYAKLR-KWV--QRLGPA---GLQSVE-E--------ALK-EGS--------------ASTPASK-DFMEAYTKLKEIIEKTDFIEKLKES-GEV---DVV-AE--------DS--LYV-LIPDAATYLQASGRTSRLYAGGVTKGLSVVLV--DS--EPLFRGLKKRLA--WVVEE---W------K-----------------EF------------ES------L-------NLSELLKEIDEDRKKVLKV-IR-G
>GBC99349.1 Reverse gyrase [bacterium HR17]
-------------------------------------------------------------------------MSSF---------------------------------------------------------------------------------------ATFRRLCPNCGGDISA-ERLEAGWACENC-LPD-RA--------------------------VS-TSSAPSGLCDFLRQRGNL-------H----HYR-WVC--YLQDTERAFAAFFRRHL-GVDLWALQRVWARRVLLGESFALIAPTGVGKTTFGIAMAHFL-P-------------G----TAYIVVPTRLLVEQV---AERCR-AF---------------------GTK------------KVVAYL-GR--------T-RERKAIET-GDY-E------VLITTSMFLATSFDL-L-NG--RT-----FDFVFVDDVDALLKS-GRNVDKVLKLLGFTD--ADIDAA-------WKERRGAQTAPLVP-----------DEGE------EEA-EEA----EMDE-------VFGEAG-EDEGSEETPSVLRP--A--SR-PK--G-VL--VVSSAT--LRPRTK-RVLLFRALLGFEVVPVRV-TVRNVCDAVQ----WVRD---------------VNDA-KRQLV------------RWVERFG-K---GGIVFVSGELGRDG-------VADIVAWLQRH-KISAVAYDEL-VAN---SDQLQAFQRGDIAVAVGIAIPTNALVRGIDLPETVRYAIFMDVPKMTFPLT------AT-D---DPRSFVPLLLALREV-S-DDK--------ARI-DAYLSTMR-RYR---------------------------FWR-SDQ-----PR------------PK-RVQEIADYLRQQFADEGVLAKLEIA-ETV---ALH-RQ-------DGQ--LFI-TLGDAASYLQASGRTSRLFAGGISRGISLILA--WD--KKAFHSLQRRLR--LFYDE-VEF------A-----------------DA------------EQ------V-------DWDAELHKVDDDRRRIRQL-QA-G
>WP_110380052.1 reverse gyrase [Acidianus sulfidivorans]
----------------------------------------------------------------------------M------------------------------------SEQLPE---------------------------------------------VVYMNSCPNCGKNITS-TKLYNGSACSEC-VPE-SINFDSFEK-----------------------------LLTYLSDNNRL-------L----YLE-SYY--RTLLEIKKVEKLFLSIL-GSPPLGPQRSWIIRALRGESFSIIAPPGLGKTTFGIIMSLYF-SS-L--------K-K----KTLMLFPTKTLVTQV---IQKIQ-DM----SKN-------M-EF---------------V-PKLAYYY-SGL--TQSVKQ-ELQKSIES-DDF-D------IFISTSRYLINNYDF-I-SAH-------DYKYIFIDDIDSVLKS-GKSAYTVLKLVGFSE--DDINNV-------RDLLRKSR---N-------------------------D--PT----VFDE-------I-----------RKIREKRFK-----DR-------IS--IFSSAT--IT-KSN---PVFSSLMGFRPGSASI-YLRNVIDSYID---VTSV--------------DEKKL-LDITN------------TIVNKLG-S---GGLIFVPVDRGIGF-------AKYIADNISG---EKVEVISSSS------ITKLDKFERGEIDSLVGVATHYGILVRGIDIPWRIKYALFVGIPKFRFKLG---------ET-MHPLAMLKMLTLISLI-V----------KDDNI-IKTYRIVR-NYL--RKTSPT---ALAMIA-K--------SVK-EGN-----MAS----------VDK-YIQQGYDIVNNYLKDKEILSKISDI-GEI---SV-----------SGD---YI-MTPDYLTYIQASGRTSRIFGGALTTGLSILLV--DD--KKLFELLNRKLS--LILDS-VNW------N-----------------LF--------DLENNK------VGN----WNLFDLKKRIDSEREKIQEV-REKG
>WP_096601531.1 reverse gyrase [Hydrogenobacter hydrogenophilus]
--------------------------------------------------------------------------MIK---------------------------------------------------------------------------------------SILLRLCPNCGGDISA-DRLLKGLPCNVC-MP--D----------------------------E-EKP----LC------SVL-------K--QGELK-KLC--YVEEQLKEWEEVFEMYI-RSKPWSLQFAWAKRVFLGSSFALLAPTGVGKTSFGLSLAFYL-A--K-------KG-K----KSYIILPTRLLVNQV---SKRLK---------K-------M-GI---KDS------------DLLTFG-DE---ERKKKE-EKKERLVK-GDF-L------ILVSTSMFLYRNYQL-I-P---KD-----MSFVFVDDVDSFLKT-AKNVDKALYLLGFSE--EDIEKA-------MNLIRLK--------------------EK------FKK-TDQ----DWER-------I-----------RELSNQLRE-LS--QK-VK--G-VL--VVSSAT--SNPRSN-RIKLFRELLGFEVGTPTF-YLRNIVDAYA----HY------------------QE---QDLS------------EWIKKLG-K---GGLVFLPSDKGKEE-------VSNLVKSLEEK-GIRAVSYEDL--D----EKHLHDYEKGKIDVIVGIASYRNPLARGLDMPHVVRYALFYGVPKIVISL-------SF-E--KSLSHLLWALSSVRHH-I-AK--HLSH-HIQKV-DNWISKLK-RYQ---------------------------YIN-EEY-----LEE-------KKDLKD-KIDQLREEIRQFLMSQEVISIIETS-EDL---TLR-LV-------NGD--YQM-VVSDATGYLQASGRTSRMFAGGITKGLSLLLV--DD--PRAFNHLKKRVR--WFSED-IDF------V-----------------PI------------SS------V-------DLEKVLLEIDNDRAKVKEF-LK-G
>PCN50874.1 reverse gyrase, partial [Candidatus Geothermarchaeota archaeon ex4572_27]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------ALFKQACPNCRGDISD-DRLLAGLPCREC-LDD-KEAE-EVLK-GAERGG-------------DLKRL----VVEALRRSGKL-------K----HYV-EAA--APHLMVEEFNEFFKRAV-GYPLWSAQRTWAKRILTGRSFAIVAPTGVGKTLFGLAMAVFL-AS-R--------G-R----RCYVVSPTTLLVEQA---RRRLE-EI----VRA-------S-GV---DVK-------------LAYYS-AAL--HRAERE-EQIAKIRD-GDF-D------ILITTSSFLARKFDL-L-RR--M-----KFDFIFVDDVDAILKA-SKNIDRVLVLLGLSE--EVIGRA-------LELIRLRR---EIA---RAARHK--------EPN-----LDE----LRAK-------A-----------EELDREVERALR--RR--K-LG-LL--VVSTAT--GRARGT-RVKLFRELLGFEVGSRAE-AIRNIQDVYV----RPEG-D----------------I-DVAVA------------DLVAKLG-G---GGLVFVPLDRGVEA-------AERIAELLRER-GVRAHVVYAK--GR---KEEVEAFAEGEVDVLIGMASYYGLLVRGLDLPETVRYAVFAGVPKMRFTL-------DL-RE-AYPSRLLQLLIDVKDV-L-GGD------EQAKA-LRLIGRMR-RLL--WRLTPA---SFEELK-R--------ALD-EGV-----EPP-SW----LKQAYQ-TVKEAAEFVFQALSREEVRAKLRES-SYL---SFT-EE-------EGK--VVV-TVPDVPTYIQASGRTSRMYAGGVSKGVSVVFV--DD--ERVFNGLMRQTR--WLAEE-VRW------A-----------------RL------------DE------V-------DLGALMREVDEDRERIRRL-LR-G
>AKT33905.1 Reverse gyrase [Pyrobaculum sp. WP30]
--------------------------------------------------------------------------ME----------------------------------------LP-------------------------------------------LV--VYLHSCPNCGGPITS-DRLAAGLPCREC-LPR-EVR-------------------------ARAVAE----VVEALRRRRAL-------R----GMA-WVG--EYLRAYEEFSAFFRGVV-GYEMWGAQRLWARRLVRGKSFAVVAPTGSGKTTFVLVSALHF-AR-R--------G-G----RVLLIFPTSALAHQA---HRRLV-AY----AER-------A-GV---SLR-------------ALAYH-SLL--GEGEKR-GVLEAVER-GDF-D------VLIVTSAFLPKYFGL-L-SR--Y-----KFDFVAADDVDSMLRATSKNIERILRLMGVSE--EVLGMA-------LEVINLAR---QLR---KAEV-A----GD------LKE-VER----LSQE-------V-----------SSLRSRLQEAVR--GL--R-LG-VF--VASGAL--AKARRTTRLLLFREILGFDVGGRAE-GLRNVVDLYV----EASQ-----------------DV-AAQVV------------ELLRRLG-P---GGIVYVQD---RDL-------GASIVERAKEA-GLAVEHFFRP---R---RGVLEAFERGEVAVLVGLASARSALVRGIDLPHVIRYVVFVGVPKFRFRV-------RI-EE-FSIPAYLTFLYNVRSV-L-AGD------LRYKA-DRLIGQLK-RLAP---YAL----SVQAAL-K--------KSM-EGA-----ELS-SF----DRHAVE-VVRSAVEFVGGLLQLEEVKRAVESA-TEV---KLA-YI-------DGE--LYV-LVPDVTTYIQGSGRTSRLYAGGLSKGLSVVVV--DD--RKVFYALQRELK--LRFDE-AEF------R-----------------HI------------NE------V-------DLGAVLAEVDRDRKVIRDI-VE-G
>WP_041077404.1 reverse gyrase [Thermotoga caldifontis]
--------------------------------------------------------------------------MPL---------------------------------------------------------------------------------------AVYDALCPNCGGRIEA-ERLQEGLACEKC-LP--EI--------------------------EK-GD-----LCELLKEK----------K----FYS-FVC--ELAEKERQFAEFFEERV-GNPPWSLQRLWAKRVFQKQSFAIVAPTGVGKTTFGAAMASFL-D-------------G----KSYILVPTRMLVEQV---KNRCE-SF---------------------TNK------------RVVAYT-GK--------E-NEKKKIEQ-GDF-D------ILITTNMFLAQNFDI-L-ED--KR-----FEFIFVDDTDSLLKS-GKNVDKVLRLLGFDQ--SHIELA-------LK-----------------------------------------------------------------------NQLES--P--PE-NT--A-VL--VVSSAT--LKPRTN-RVVLFRKLLGFDVSPVRI-SVRNVLDSFV----EVED---------------EETA-RAQLL------------DWIERFG-R---GGLVYVSSRFGKEG-------VEELVSWLKEH-GVRAVSYEDF---------DPESFRKGEFEVAVGIALPNNSLVRGLDLPDTIRYAIFFDVPHLTFPL-------KL-E---NENVQRSLLLALRNF-V-NDE---------RI-EKYLK-VL-SGR----------------------------VS-LAQ-----R------------------QQIENFLAELLEKNETVEKLKNS-EDI---LIG-ER-------EEG--LYV-SFADAATYLQASGRTSRMFAGGVSRGISLIVH--WN--ERLFKNLKKRLR--LFFDD-VDF------I-----------------DA------------KE------I-------DWQQELKRVDEDRATIVKV-LS-S
>RKZ22997.1 reverse gyrase [bacterium]
-------------------------------------------------------------------------MKPD---------------------------------------------------------------------------------------AIFTEFCPVCGKDISL-RELEEG----KC-ENT-G-------------------------------------------------------K--------ELRNLKFEEKIKGFSEFFEQAL-GSPPRSIQLMWARRIFRGRSFAALSPPGIGKTVFGIITSLFL-AR-E--------N-K----KSYILLPTSTLLTNV---LEKIN-SF----MEK-------T-GK-----------------TEVVAYH-ASM--K--DKE-NIKEKIKK-GEF-K------ILITTTQFLSRNFSL-L-RG--K-----FFDFIFVDDVDSVLRA-SGNVERILKLLGFSD--R-------------------------------------------------E-IRR----VERK------------------------------------GR-KG-VI--MVSTAT--GR-KGE-KTYLFRNLLGFDVGMLTE-IVRNVEDLYI----PEKS--------------------IKVLE------------EVLKKMG-D---GGIVLFHE---EEE-------MKEVLKEIKRK--LKAGYVTAR--R----KKDLERFARGELDYLFGVAAFYGILTRGLDLPGRIKYAVFYGIPHFKLKL-------NL-EN----APSSVLLRLAQLM-HEEDEE-----------------LE-KAL----------------------------------------------------EEK-NEEKIRERLSLLFSSLSSEEL--LK-YRL---IK------------EN--DYL-VLPDIRTYIQASGRTSRLTRGGITRGASIVLD--TP--ERI-TLLEEKGK--FY--G-IEW------K-----------------PF------------SS------I-------SLPSILKEIEESRKKI----KE--
>WP_068669685.1 reverse gyrase [Thermosulfurimonas dismutans]
---------------------------------------------------------------------------ML---------------------------------------------------------------------------------------FKIAHGCPNCGHEISD-TRLAQGLPCETC-LPE-LK-------------------------NHP---------CQALEENRKL-------L----GFE-PFC--RVEKELVRFQEAFEKAL-GLKPSSLQLSWAKRLFLGESFAIVAPTGTGKTTFGLLSLLLL-P-------------G----KNLILVPTRLLCEQL---AARLL-EM----AEK-------I-GL----QR------------SILAYR-GR--------K-KEKEAFLS-GDY-E------ILVATSAFMYKQAEE-F-Q---KA----SFSLVFVDDVDAFLKN-SRHVETLFKILGFTE--EELSLA-------LK---------------------------------KGK-TPE----DYER-------L-----------KIIRSR--A--------GR--G-QL--LLSSAT--LKPRGA-RLALFQNLLGFDIQRAVS-SLRNITDTYE----VLTR----------------ERL-LQRAT------------ELIKVLG-S---GGLVFLSEEFGKDR-------VEDVTQFLRSQ-GIKAISYLEE--KP---EKLMARLRAGEFEVAVGLSHLSNPLVRGIDLPEILRYAVFVGVPKHVFPL-------KL-E--DTPARLQNLLSALLPL-F-END------DQLTA-LSYLRYLK-SYF---------------------------TLR-AED-----LHR-------YPRLAK-RIREIRNFLEKHLNDPAFQERLKQS-EEV---FLE-ET-------DDG--LRV-VVGDAATYLQASGRVSRLSAGRVLPGLSLVLA--ED--SKAFVSLVHRLT-FFLGEP-PAF------I-----------------PL------------SK------L-------DLAEESRKLTEARKDTR----K-G
>WP_031505016.1 reverse gyrase [Pseudothermotoga hypogea]
--------------------------------------------------------------------------MIF---------------------------------------------------------------------------------------AVFESLCPNCGGRIDA-ERLEKGLVCERC-LP--EP--------------------------KE-GD-----LCELLEKR----------Q----FYE-SVC--ELMEKERRFAEFFHLGV-GNPPWSLQRHWAKRIFQGQSFAIVAPTGVGKTTFGAAMACFL-E-------------G----KAYILVPTRVLVKQV---KQRCE-SL---------------------SNK------------RVIAYT-GR--------E-SEKERIRK-GDF-D------VLITTNMFLSRNFDA-L-ED--KR-----FDFIFVDDTDSLLKS-GKNVDKVLRLLGFTQ--RQIDLA-------VR-----------------------------------------------------------------------NQLQE--E--PK-PK--G-IL--VVSSAT--LRPKTN-RAVLFKELLGFDVSPVRI-SLRNVLDTYL----HVGN---------------EEEA-LERLV------------EWIRKLG-D---GGFIYISSRFGKEG-------VDKIVSWLRKH-KIEAVSYEEF---------DPGEFRKKKFKVAVGISMPNNVLVRGLDLPDVVRYAIFLNVPHVSFPM-------RF-E---NENVQRALLVALRNL-V-QDE---------RI-EKYLSWII-SKR---------------------------RRT-IDQ-----S------------------QEIAKFLSEQLSKEEILEKLKSS-NDV---LIE-EN-------DSD--LFI-SLADAATYVQASGRTSRMFAGGVSRGISLVIF--WN--EKLFNNLKKRLR--LFFDE-IDF------V-----------------HA------------ED------V-------DWQQELERVDEDRNKIVKL-FS-A
>PVU78731.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MTS------------------------------------IDKVPP---------------------------------------------SIYTRSCPNCGGNISS-QRLFNGSVCESC-LKE-DKEFNNLSD-----------------------------LINILSENNTL-------K----NLN-QLY--NILEEYKEVEEIFSKLLNSSKPIGPQRSWIIRFLRGESFAIIAPPGLGKTTFGLIMSLYN-AT-R--------N-R----KSIIIFPTRTLISQT---VDKLA-KF----SES-------Y-SY---------------S-PRILY---NKQ--SSTQTE-NVLEQLKS-GDF-D------IFVSTSRYVIQNLSE-L-SNV-------KFDFIFVDDVDAALKS-GKSAKAILRLVGFTD--EDIQTT-------MKLLRENI---G-------------------------D--EE----KFGK-------I-----------QEIRENKLK-----DK-------IV--IFSSAT--IS-RGN---PTLSSLMGFRPGSSVI-YLRNIYDSYID---LTQTCK---------ERDVDECT-LGTVI------------RVLKRLN-D---GTLIFVPIDKGVQY-------AEYLASNLRDH-GINAESVASSS------ISKLEKFERGEVGSLVGVATHYGVLVRGIDLPWRVKYSIFVGIPKFKFKIG---------EY-MHPLALTRLLSLVYLV-K----------NDDKI-RGLLSYIR-KRL--RRISPA---ALAMLA-K--------DIR-EGK-----ID------------DE-RLKEAYSLVNEYLKDTEFLKKISAV-GDL---VI-----------EGD---YI-LMPDYLTYIQASGRTSRLYGANLTTGLSVLLI--DN--LRLFELLNKKLN--LILDE-VKW------Y-----------------PL--------DIDADR------LGQ----VSLSDIVTKITEERENLSKM-KKEG
>WP_033192706.1 reverse gyrase [Fervidobacterium islandicum]
-----------------------------------------------------------------------MNATLE---------------------------------------------------------------------------------------AVFKNLCPNCSGDISS-IRLIKGLPCEKC-LSE-E---------------------------IDGKGA----LCR-LSNLEGL-------K--E------FC--NLNQEYTEWEETFKKYV-GFEPWELQKFWAKKLLLKRSFALLAPTGIGKTSWGFASAIYF-A--K-------HN-K----KSYIVLPTRLLLLQS---YEKLK-----------------G-KV---PDK------------DLLVIGIEE---SKKEKD-QNKERLAN-GQF-K------VLVTTSMFLYKNVDL-I-P---RD-----FSFIFVDDVDSFLKT-AKNIDKALYLLGFEP--RDIELA-------MKYIRMR----------------------------RNI-TEE----NTEE-------I-----------NSLREQVRR-IS--KK-AK--G-VM--VVSSAT--SNPKSE-RIKLFKELLAFDVGRPVF-YLRNVEDIYE----HVG--------------PDQAKL-ESVLV------------EKIKQFG-D---GGLVFVSSDYGKEK-------VDELKALFQRF-GITSESYENF--S----EEILEKYKNKEIQVLIGISSYRNPLARGLDLPEIIRYAVFYGVPKIVVSL-------DL-E--GNVKHILLALSTLRPL-I-ARDRELEN-WTPTV-DRWMKELS-KLG---------------------------NIA-----------N-------PP--KE-RVEKLREEIKNFILSEKVASKIKSA-DDI---SLR-QE-------DGK--WYL-VVADVTGYLQASGRTSRLFVGGISKGLSYLLV--DD--KKVFNNLIRKLR-WWFSSD-VVF------K-----------------DA------------QS------V-------DLESIIEQINSDRERVRK------
>WP_054845110.1 reverse gyrase [Sulfolobus sp. JCM 16833]
-----------------------------------------------------------------------------------------------------------------MSNVPY---------------------------------------------SIYISSCPNCGGDIEA-DRLAKGLVCRSC-MPK-EIDVNGLES-----------------------------LLRYLERRGNL-------K----SMK-ETL--SVYKEAQFISEFFKLAL-KTGPIGPQRSWIMRLAKGESFSIIAPPGLGKTTFGVISSVYL-ASKR--------K-K----KSLLMFPTKTLVNQV---KQKVQ-QV----ASN-------T-SS---------------D-VRLLVYD-SGM--KQAQRA-EFMKSLGE-EDF-D------IAILSSRFAMMNLEN-L-SVL-------DFDFLFVDDVDSALKS-NKSARTVTLLAGYTD--EDIERV-------KELLKQSY---N-------------------------D--PS----AFSK-------I-----------ASLRKR--------DK-------VV--VFSSAT--VN-RSN---PVLSSLMGFKPGSSNI-YLRKVVDSFIE---MPK---------------DENSV-IEMVD------------SLIKKLG-S---GGLIFVPVDKGNKY-------SEQVARELDG--DLRVISLSSSS------VRKIDEFKNGDVDVMVGVATHYGVLVRGIDIPCRIKYAIFLGIPKFRFTMG---------EA-IHPLTALKLLTLIAQV-R----------KDNSI-TSILYRAK-RRL--RRASVA---SLSMIA-R--------DIK-DGK-----DL------------DP-ALKDMYAVLYENLKDVDVLEKISEI-GDV---VI-----------EGN---SI-MMPDYITYVQASGRTSRLFGPELTTGLSIVFV--EN--QNLFRMLQKKLS--FVLDE-NNW------S-----------------KL--------DLVEGK------VED----IPLSQLMSKITRERKEIALA-RSSG
>WP_012717347.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MTS------------------------------------IDKVPP---------------------------------------------SIYTRSCPNCGGNVSS-QRLFNGSACESC-LKE-DKEFNNLSD-----------------------------LINILSENNTL-------K----NLN-QLY--NILEEYKEVEEIFSKLLNSSKPIGPQRSWIIRFLRGESFAIIAPPGLGKTTFGLIMSLYN-AT-R--------N-R----KSIIIFPTRTLISQT---VDKLA-KF----SES-------Y-SY---------------S-PRILY---NKQ--SSTQTE-NVLEQLKS-GDF-D------IFVSTSRYVIQNLSE-L-SNV-------KFDFIFVDDVDVALKS-GKSAKAILRLVGFTD--EDIQTT-------MKLLRENI---G-------------------------D--EE----KFGK-------I-----------QEIRENKLK-----DK-------IV--IFSSAT--IS-RGN---PTLSSLMGFRPGSSVI-YLRNIYDSYID---LTQTCK---------ERDVDECT-LGTVI------------RVLKRLN-D---GTLIFVPIDKGVQY-------AEYLASNLRDH-GINAESVASSS------ISKLEKFERGEVGSLVGVATHYGVLVRGIDLPWRVKYSIFVGIPKFKFKIG---------EY-MHPLALTRLLNLVYLV-K----------NDDKI-RGLLSYIR-KRL--RRISPA---ALAMLA-K--------DIR-EGK-----ID------------DE-RLKEAYSLVNEYLKDTEFLKKISAV-GDL---VI-----------EGD---YI-LMPDYLTYIQASGRTSRLYGANLTTGLSVLLI--DN--LRLFELLNKKLN--LILDE-VKW------Y-----------------PL--------DIDADR------LGQ----VSLSDIVTKITEERENLSKM-KKEG
>WP_013267159.1 reverse gyrase [Acidilobus saccharovorans]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------MCPNCGREITA-DRLEKGLPCAVC-LPR-EPKSGDIL-------------------------E----IGLELAKEGKL-------K----GYS-SLY--LMEKSFRDFSKFFEEKY-GFKLSSAQRSWARRLLSEESFSIVAPTGVGKTTLLMAYAAFK-VM-Q-------EG-Y----KVMYLVPTENLVAQT---AGRLA-SM----LGD-------K----------------------VAFYY-SSL--PKAQRS-QMLDKITR-GDY-S------VVVITPGFMVKNFDM-L-KK--QS----PFNLMIVDDVDSLLRN-SKNIDRALILIGFDE--DSIATA-------FKIVQEKL---ELV--TLEASGRS-----------EER-IRQ----LQSD-------I-----------SSLSLKLSEKVLE----GP-KG-QL--VIASAT--GRPRGV-KHLIFRELLGFEIGGGTD-YLRNVVDTFL----ITASP-------------------VDSVV------------SLAKKLG-K---GGLIFISQAYGKAY-------VKELMDKLAGA-GVKAVQAISNS------RRAVEKLSSGEVDVAIGLASRYGALVRGIDLPEVIRYAIFLGTPAIKVELKT-----AL----LSPRRLLRALIFLE-----EK-------------DSSFKEYR-EKL--ENLLKNFNVESNILS---------AAIR-GEI-----EAK-GRLEVLRELVLE-ASAKAVQALSNMIVKDG--QVLRIG-T-M---VL--RR------EGPS--IWL-YSPDAPSYLQASGRTSRLYHGTMTKGLSVIVD--NM--KELVDAMEDRLR--WMSQA-T-F------V-----------------EF------------NS------V-------NLEDVTREIEASRSE------K-G
>WP_012713906.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MTS------------------------------------IDKVPP---------------------------------------------SIYTRSCPNCGGNISS-QRLFNGSVCESC-LKE-DKEFNNLSD-----------------------------LINILSENNTL-------K----NLN-QLY--NLLEEYKEVEEIFSKLLNSSKPIGPQRSWIIRFLRGESFAIIAPPGLGKTTFGLIMSLYN-AT-R--------N-R----KSIIIFPTRTLISQT---VDKLA-KF----SES-------Y-SY---------------S-PRILY---NKQ--SSTQTE-NVLEQLKS-GDF-D------IFVSTSRYVIQNLSE-L-SNV-------KFDFIFVDDVDAALKS-GKSAKAILRLVGFTD--EDIQTT-------MKLLRENI---G-------------------------D--EE----KFGK-------I-----------QEIRENKLK-----DK-------IV--IFSSAT--IS-RGN---PTLSSLMGFRPGSSVI-YLRNIYDSYID---LTQTCK---------ERDVDECT-LGTVI------------RVLKRLN-D---GTLIFVPIDKGVQY-------AEYLASNLRDH-GINAESVASSS------ISKLEKFERGEVGSLVGVATHYGVLVRGIDLPWRVKYSIFVGIPKFKFKIG---------EY-MHPLALTRLLSLVYLV-K----------NDDKI-RGLLSYIR-KRL--RRISPA---ALAMLA-K--------DIR-EGK-----ID------------DE-RLKEAYSLVNEYLKDTEFLKKISAV-GDL---VI-----------EGD---YI-LMPDYLTYIQASGRTSRLYGANLTTGLSVLLI--DN--LRLFELLNKKLN--LILDE-VKW------Y-----------------PL--------DIDADR------LGQ----VSLSDIVTKITEERENLSKM-KKEG
>WP_012674047.1 reverse gyrase [Sulfurihydrogenibium azorense]
--------------------------------------------------------------------------MIY---------------------------------------------------------------------------------------AIFEKLCPNCHGEISS-YRLEKGLPCKKC-LPD-E----------------------------D-LDV-----C------QHV-------K--PGDIK-QLC--HLQDTLQTWQEHFQTYI-KSKPWNLQNTWAKRVFLKHSFVLLAPTGIGKTSFGISMASFL-A--K-------QG-K----KSYILLPTKLLVKQV---YEKVK---------N-------F-GV---DKK------------DILAIGLEK---SNKEKE-ENKERLKN-ADF-K------ILITTSMFLYKNFEI-Y-P---RD-----FEFIFVDDVDSFVKT-AKNIDKALYLLGFTQ--EDIEKA-------LILIKLK--------------------AK------PNK-TQE----DWDK-------I-----------NQLTEYLQK-QR--KK-IT--G-VL--IVSSAT--SKPRSN-RVKLFRELLGFEISSPTF-YLRNIVDSYD----EE------------------YS--FEKLL------------YWINKLG-K---GGLVFIPSDKGKEF-------VDEVVEKLNKH-KIKAVSYEEL--D----DKNLKKFEEGKIQVLVGISSYRNPLARGLDLPHVIRYALFYGVPKISISL-------KL-E--ENLSHMLWALTSIRSY-V-IK--KFPE-ITIKI-NQWITQLQ-KYQ---------------------------NLT-LDF-----IQN-------NPQLKE-KIENLQKEIRDFFQRPEVLEVLKSS-DEI---VLK-QK-------EDG--YYL-IVSDATGYLQASGRTSRLYAGGITKGLSLILI--DE--KSAFKHLNKRVK--WFSEE-IEF------V-----------------NI------------NQ------V-------NLDQLIKQIDEDREKVRNF-LT-N
>WP_012716359.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MTS------------------------------------IDKVPP---------------------------------------------SIYTRSCPNCGGNISS-QRLFNGSVCESC-LKE-DKEFNNLSD-----------------------------LINILSENNTL-------K----NLN-QLY--NILEEYKEVEEIFSKLLNSSKPIGPQRSWIIRFLRGESFAIIAPPGLGKTTFGLIMSLYN-AT-R--------N-R----KSIIIFPTRTLISQT---VDKLA-KF----SES-------Y-SY---------------S-PRILY---NKQ--SSTQTE-NVLEQLKS-GDF-D------IFVSTSRYVIQNLSE-L-SNV-------KFDFIFVDDVDAALKS-GKSAKAILRLVGFTD--EDIQTT-------MKLLRENI---G-------------------------D--EE----KFGK-------I-----------QEIRENKLK-----DK-------IV--IFSSAT--IS-RGN---PTLSSLMGFRPGSSVI-YLRNIYDSYID---LTQTCK---------ERDVDECT-LGTVI------------RVLKRLN-D---GTLIFVPIDKGVQY-------AEYLASNLRDH-GINAESVASSS------ISKLEKFERGEVGSLVGVATHYGVLVRGIDLPWRVKYSIFVGIPKFKFKIG---------EY-MHPLALTRLLSLVYLV-K----------NDDKI-RGLLSYIR-KRL--RRISPA---ALAMLA-K--------DIR-EGK-----ID------------DE-RLKEAYSLVNEYLKDTEFLKKISAV-GDL---VI-----------EGD---YI-LMPDYLTYIQASGRTSRLYGANLTTGLSVLLI--DN--LRLFELLNKKLN--LILDE-VKW------Y-----------------PL--------DIDADR------LGQ----VSLSDIVTKITEERENLSKM-KKEG
>KUJ98184.1 Reverse gyrase [Thermodesulfobacterium sp. 37_54]
---------------------------------------------------------------------------ML---------------------------------------------------------------------------------------YFLENGCPNCKGIVSD-ERLGKGIPCENC-LPE-GK-----------------------IPSNPSILK----ICEILEKEKTL-------K----QLK-IFG--EVEKQVSNFSKLFKEII-GAKPSSLQINWAKRLFLGESFAIIAPTGTGKSTFGLISALLT-P-------------K----KALIIVPTKMLVNQV---ETKLN-DF----IDR-------T-SSLALKKK------------RILAYT-GQ--------K-KEKEILEK-QNF-D------VFICTSAFMHKNFEI-L-K---SL----DFSLIFVDDVDSFLKS-SKNVDNLFLLLGFSE--EEIKLA-------LK---------------------------------RDK-TEE----DYSE-------L-----------LKIKKNHRS--------TQ--K-QL--IISSAT--LKPRTN-RVLLFQNLLGFEITRFVS-TLRKVIDTYL----DV----------GEPRDI--QRL-SEEAV------------KLIKALG-K---GGLVFVEESYGRTY-------VEKFTEQLREN-GVKAISYLEV--SE---EDLLNKLKQGEVEVAVGLCHLGNPLVRGLDLPEILRYAIFLGVPKHVFPLMKNEVSFSL-S--VAPQFLYSLLLSLMPL-F-KDD------ERITA-LSHVNYLR-RFL---------------------------TLR-EED-----LPK-------YEGLYK-KVLSIKEFIEERLKNPEFIEKLKTN-EEV---FLERDE-------NGN--YHL-IVGNASSYLQASGRVSRLTTKGLMPGLSVILV--DS--FKALNSLKKRLR-FYLGDE-VEL------T-----------------EV------------NF------E-------KIIELDTQIKQEREKIS----A-E
>WP_012953015.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MTS------------------------------------IDKVPP---------------------------------------------SIYTRSCPNCGGNISS-QRLFNGSVCESC-LKE-DKEFNNLSD-----------------------------LINILSENNTL-------K----NLN-QLY--NILEEYKEVEEIFSKLLNSSKPIGPQRSWIIRFLRGESFAIIAPPGLGKTTFGLIMSLYN-AT-R--------N-R----KSIIIFPTRTLISQT---VDKLA-KF----SES-------Y-SY---------------S-PRILY---NKQ--SSTQTE-NVLEQLKS-GDF-D------IFVSTSRYVIQNLSE-L-SNV-------KFDFIFVDDVDAALKS-GKSAKAILRLVGFTD--EDIQTT-------MKLLRENI---G-------------------------D--EE----KFGK-------I-----------QEIRENKLK-----DK-------IV--IFSSAT--IS-RGN---PTLSSLMGFRPGSSVI-YLRNIYDSYID---LTQTCK---------ERDVDECT-LGTVI------------RVLKRLN-D---GTLIFVPIDKGVQY-------AEYLASNLRDH-GINAESVASSS------ISKLEKFERGEVGSLVGVATHYGVLVRGIDLPWRVKYSIFVGIPKFKFKIG---------EY-MHPLALTRLLSLVYLV-K----------NDDKI-RGLLSYIR-KRL--RRISPA---ALAMLA-K--------DIR-EGK-----ID------------DE-RLKEAYSLVNEYLKDTEFLKKISAV-GDL---VI-----------EGD---YI-LMPDYLTYIQASGRTSRLYGANLTTGLSVLLI--DN--LRLFELLNKKLN--LILDE-VKW------Y-----------------PL--------DIDADR------LGQ----VSLSDIVTKITEERENLSKM-KKEG
>Q08582.3 RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Sulfolobus acidocaldarius DSM 639]
--------------------------------------------------------------------------MQS------------------------------------LSDIPP---------------------------------------------SIYLFSCPNCGRSIST-YRLLLGSVCNIC-LEE-DKEYKNIGD-----------------------------LIKDIEKQGNL-------I----KLK-DIQ--RVLDDYESFVSVFRRLL-GFPPFGPQKSWIYRLLSGESFAIIAPPGLGKTTFGLISSIYL-YL-R--------G-K----KSILVFPTKSLVRQA---IDKLS-SYIQNLAEI-------K-EN---------------P-PKVIYYY-SGM--SASERK-EADEGLQS-KTF-D------IFISTNRFLIDNIDQ-I-SST-------SYQFLFVDDVDTALKS-SKSAQAILKLLGFTP--SDQDKI-------KESLKKYR---ENTQ------------KN------EQN--EY----IFEE-------I-----------DKIRKDRLA-----SK-------TV--IFSSAT--LN-RSN---PILTSLVGFKPGSSVI-YIRKVYDMYVK---QPD---------------KEQET-FNLIK------------SLLHRLG-D---GGLIFVPVDKKQEY-------IKRLQSELSN--EFNVAAITSTS------ATKIDDFANGEIDVLIGSATHYGILVRGLDLPWRVKYSIFVGIPKFKFRLG---------EK-VNLLTLSRLLSLIALI-T----------KDQEV-IYISRRVK-DKI--RRLSPA---ALTMLS-V--------QAK-EGK-----LE------------DS-ILLKAYDLLNKYLSNQNVLKRISEI-GDF---VL-----------SPD--NDI-LIPDYLTYVQASGRTSRIYAGDVTTGLSILLV--DD--FNLFRLLNKKLQ--YILDD-IQW------R-----------------EL--------DVEKWT------AGD----VEIKNLISKINEERNEISKL-KNEG
>WP_052885072.1 reverse gyrase [Thermofilum pendens]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MER----LVKVLGKSGKL-------L----HLE-ELY--SVERDLADFQAFFRKAV-GSRPWSAQKTWARRVLRNTSFVILAPTGVGKTVFGIVMALFL-AS-R--------G-K----KSYIVLPTTTLAQQV---FEKAT-LF----ARK-------V-AV--NEGG-------------IVVYH-GGL--PQSKKE-EVLSRVSG-GDF-S------VLITTSQFLSRNFDK-L-ER--V-----RFDFVFVDDVDSIIKS-SKNIDRILRLLGFTQ--DEISVA-------LEIIRERV---RLA---RRLRNG-------------AS-TSD----VYER-------L-----------EELRRKLAEYTG--KGG-P-RG-VL--VVSTAT--GRPRGL-RIRLFRELLGFEIGSRGE-LFRNVVDTYV----VVDRDE---------------EV-VRQVA------------TLASRLG-R---GGLVFAPAGTGEEF-------LESLAEALEKS-GLRVGRFYGNH-NK---RKLLEEFSGGNLDVLVGVASYYGTLVRGLDLPHVVRYAIFAGIPHFKFSI-------KL-ED-VPPLRLLQIASNVRVV-A-SRD------DQAVI-DRLVAYVR-NWL--QNMEPG---EYMALT-Q--------CLS-EGS-----CHE------KYSRLVE-SINHLRSIVEKYLSSKEYLERLSKE-TSL---TVV-SE-------DGQ--LKL-LLPDVLTYIQASGRTSRLYARGVSKGLSIVVT--GN--GLLFEKFAKFSR--LYSSD-IEW------K-----------------PL------------SE------V-------DLDLLVREIDEEREIIRRI-LS-G
>WP_015385507.1 reverse gyrase [Sulfolobus acidocaldarius]
-----------------------------------------------------------------------------------------------------------------MSDIPP---------------------------------------------SIYLFSCPNCGRSIST-YRLLLGSVCNIC-LEE-DKEYKNIGD-----------------------------LIKDIEKQGNL-------I----KLK-DIQ--RVLDDYESFVSVFRRLL-GFPPFGPQKSWIYRLLSGESFAIIAPPGLGKTTFGLISSIYL-YL-R--------G-K----KSILVFPTKSLVRQA---IDKLS-SYIQNLAEI-------K-EN---------------P-PKVIYYY-SGM--SASERK-EADEGLQS-KTF-D------IFISTNRFLIDNIDQ-I-SST-------SYQFLFVDDVDTALKS-SKSAQAILKLLGFTP--SDQDKI-------KESLKKYR---ENTQ------------KN------EQN--EY----IFEE-------I-----------DKIRKDRLA-----SK-------TV--IFSSAT--LN-RSN---PILTSLVGFKPGSSVI-YIRKVYDMYVK---QPD---------------KEQET-FNLIK------------SLLHRLG-D---GGLIFVPVDKKQEY-------IKRLQSELSN--EFNVAAITSTS------ATKIDDFANGEIDVLIGSATHYGILVRGLDLPWRVKYSIFVGIPKFKFRLG---------EK-VNLLTLSRLLSLIALI-T----------KDQEV-IYISRRVK-DKI--RRLSPA---ALTMLS-V--------QAK-EGK-----LE------------DS-ILLKAYDLLNKYLSNQNVLKRISEI-GDF---VL-----------SPD--NDI-LIPDYLTYVQASGRTSRIYAGDVTTGLSILLV--DD--FNLFRLLNKKLQ--YILDD-IQW------R-----------------EL--------DVEKWT------AGD----VEIKNLISKINEERNEISKL-KNEG
>OYT67180.1 reverse gyrase, partial [Thaumarchaeota archaeon ex4484_121]
-------------------------------------MD-----------------------------RAGTMVAR----------------------------------------------------------------------------------------AIYSFACINCGGEILD-ERLLKLGLCERC-L-----PD---------------------VGDI-DLQQ----AIEILKSGGRL-------K----RLK-ELS--NLYTSYLEFREFFRKAV-GFEPWALQEVWAKRILSGESFAIIAPTGIGKTVLGLVMALYL-AS-K--------G-K----RCYVIVPSSILAQQL---YEKAE-RF----AEG-------A-GA---GSVE------------IIAYH-AGL--SKGEKE-EALKKISK-PRS-I------LLITTDRFLVDRFES-L-KE--S-----VFDYVFVDDVDSFLKS-PKNIDRAVSLLGFDP--EVVDHA-------LKLIELRR---RIA---K----G-------------FD--KD----LAKE-------Y-----------ERVRKIVEREKR--KR--R--G-LL--VVSGAT--LRGKRTKRLMIFRELLGFEVGRLPE-FVRNIADLYI----EPEKGN----------------L-IDEAI------------SLVKKHG-P---GCLIFIPQALGRDF-------AAKVAEMFERA-GIKVHLYEKM---E---ADILQRFCDGKIDAMVGIASLRSPLARGIDLPERIRYAIFIGVPRREMII-------SR-DE-YNPTKILTLLYNIMPI-L-EKR------LKDEA-EAVAAKLS-KIVP---LNKD---LMERIR-E--------AIE-RGE-----RLE-GF----EGYAED-AIIAGREFLRKVLT-DEFIERIRRE-LDI---SIK-PI-------KEG--FSL-IIPDASGYIQASGRTSRLYAYGVTKGMSIVLV--DD--PKAFKGLTSRLR--VMLEE-LEF------A-----------------PY------------DE------K-------EAELVFREIDSERKIIREL-RL-G
>WP_090223245.1 reverse gyrase [Fervidobacterium changbaicum]
-----------------------------------------------------------------------MNATLE---------------------------------------------------------------------------------------AVFKNLCPNCSGDISS-IRLIKGLPCEKC-LSE-E---------------------------IDGKGA----LCR-LSNLEGL-------K--E------FC--NLNQEYTEWEETFKKYV-GFEPWELQKFWAKKLLLKRSFALLAPTGIGKTSWGFASAIYF-A--K-------HN-K----KSYIVLPTRLLLLQS---YEKLK-----------------G-KV---PDK------------DLLVIGIEE---SKKEKD-QNKERLAN-GQF-K------VLVTTSMFLYKNVDL-I-P---RD-----FSFIFVDDVDSFLKT-AKNIDKALYLLGFEP--RDIELA-------MKYIRMR----------------------------RNI-TEE----NTEE-------I-----------NSLREQVRR-IS--KK-AK--G-VM--VVSSAT--SNPKSE-RIKLFKELLAFDVGRPVF-YLRNVEDIYE----HVG--------------PDQAKL-ESVLV------------EKIKQFG-D---GGLVFVSSDYGKEK-------VDELKALFQRF-GITSESYENF--S----EEILEKYKNKEIQVLIGISSYRNPLARGLDLPEIIRYAVFYGVPKIVVSL-------DL-E--GNVKHILLALSTLRPL-I-ARDRELEN-WTPTV-DRWMKELS-KLG---------------------------NIA-----------N-------PP--KE-RVEKLREEIKNFILSEKVASKIKSA-DDI---SLR-QE-------DGK--WYL-VVADVTGYLQASGRTSRLFVGGISKGLSYLLV--DD--KKVFNNLIRKLR-WWFSSD-VVF------K-----------------DA------------QS------V-------DLESIIEQINSDRERVRK------
>WP_022855234.1 reverse gyrase [Thermodesulfobacterium thermophilum]
---------------------------------------------------------------------------ML---------------------------------------------------------------------------------------YFLENGCPNCKGIVSD-ERLGKGIPCENC-LPE-GK-----------------------IPSNPSILK----ICEILEKEKTL-------K----QLK-IFG--EVEKQVSNFSKLFKEII-GAKPSSLQINWAKRLFLGESFAIIAPTGTGKSTFGLISALLT-P-------------K----KALIIVPTKMLVNQI---ETKLN-DF----IDR-------T-SSLALKKK------------RILAYT-GQ--------K-KEKEILEK-QNF-D------VFICTSAFMHKNFEI-L-K---SL----DFSLIFVDDVDSFLKS-SKNVDNLFLLLGFSE--EEIKLA-------LK---------------------------------RDK-TEE----DYSE-------L-----------LKIKKNHRS--------TQ--K-QL--IISSAT--LKPRTN-RVLLFQNLLGFEITRFVS-TLRKVIDTYL----DV----------GEPRDI--QRL-SEEAV------------KLIKALG-K---GGLVFVEESYGRTY-------VEKFTEQLREN-GVKAISYLEV--SE---EDLLNKLKQGEVEVAVGLCHLGNPLVRGLDLPEILRYAIFLGVPKHVFPLTKNEESFSL-S--FAPQFLYSLLLSLMPL-F-KDD------ERITA-LSHVNYLR-RFL---------------------------TLR-EED-----LPK-------YEGLYK-KVLSIKEFIEERLKNPEFIEKLKTN-EEV---FLERDE-------NGN--YHL-IVGNASSYLQASGRVSRLTTKGLMPGLSVILV--DS--FKALNSLKKRLK-FYLGDE-VEL------N-----------------EV------------TF------E-------KIIELDTRIKQEREKIS----A-E
>ABM80779.1 Reverse gyrase 2 [Hyperthermus butylicus DSM 5456]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGELST------------------DYYERIET----IGRLLAENGRL-------R----GYW-YLY--SSTSQLREFEEFFEKLT-GHKLWSAQRTWAKRMLQGESIAIVAPTGVGKTTLLSVYAVYR-AS---------QG-L----KVYYLLPTENLARQV---TRKLE-TL----SSR-------L-GG---G-------------IRVVSYY-SSL--PKRAKE-ESLRTIEE-RSY-D------ILVTTTAFLSRRWSL-I-EG--IR-----FDSILVDDVDAVLRN-SKNIDKLLQALGFSV--EAIEAA-------YNLVKKKI---MATI-AKTSGN-------------IKR-YEK----LLQD-------I-----------EQLEAILSQELVK----TT-PG-QL--VIASAT--GRAYGL-KPKLFRELLGFDIGRVYD-YTRSIANLYK----IVNDP-------------------VAEAV------------SLVTRMG-G---GGLVFVAKRFGKNV-------ARRIAEMLNER-GIRAAVALAG-------RRVLDRFASGEYDVLVGVASYYGVIVRGIDMPERIHYTVFVGVPSQAIEAGK-----AL----LSPHRIARSAVELS--------------------LEGAEELA-RRL--SKLAPN---EVTVLR---------IALE-RGE-----RLE-GRLGEILEMLLE-TRRKLLHAIEELVSIE---GSVAVG-G-A---LY--RF------EDGK--LVA-ILPDAPTYVQASGRASRMYGSAMTHGISIVLD--VD--EILVRLLAEKLK--RFLED----------V-----------------RF------------EE------L-------SSEKLAKELEKARASRRG-----G
>WP_022853495.1 reverse gyrase [Thermodesulfatator atlanticus]
---------------------------------------------------------------------------ML---------------------------------------------------------------------------------------FLVAHACPNCGGTISD-ERLAKGLPCSKC-LPS------------------------------PQVEE----ICQELKKRENL-------R----KLA-PYC--EAREKIKEFAAYFERAV-GFKPSTLQETWAKRLFFRESFAIVAPTGTGKTTFGLLASLYF-A-------------R----KVLILVPTRLLAKQV---GEKLE-EF----SQK-------S-GL----TK------------KILVYL-GK--------K-KDKEAFSA-KNF-D------ILVCTTAFFYKHLEQ-L-I---AT----DFEFVFIDDVDSFLKR-SAHIEELFKLLGFSE--REIALA-------LK---------------------------------PRK-TEK----DFEK-------L-----------EGIRKRH-A--------GR--K-IL--LMSSAT--LKPRTS-RALLFRYLLGFEIQKAVS-NLRNIIDAYD----D-TTKD-------------FERS-LARAA------------FLIKTLG-K---GGLLFVAFDYGKEG-------VAQAVSFLRAQ-GLKALSYLEK--SP---DELMAEMEKGEFDVAVGLAHLANPLVRGIDLPFILRYAIFLGVPRHVIPT-------KV-T--LLPRSLYNVLVNIVSL-L-EED------ERLSA-LSDIQYLR-RYL---------------------------TLT-EEA-----LPR-------YPRILE-RLEKIKSFIETKFETAEFLKKLSQS-EDV---FLK-KE-------GDE--LFL-IVGDTATYIQASGRVSRLTAKGLLKGLSVVLV--DD--ARAMRSLERKLR-LQLGDD-FSF------V-----------------PV------------WE------L-------DLSAISRELSAMRQKAR----D-K
>WP_048100167.1 reverse gyrase [Candidatus Acidianus copahuensis]
--------------------------------------------------------------------------M-G------------------------------------RDDIPL---------------------------------------------ATYLNSCPNCGGDITT-LKLLAGSACDRC-VPE-ERTFNSIQD-----------------------------LILFLDSTDKL-------D----RLN-NVR--QLLGDLEKVSNLFVKIL-GSPPLGPQRSWIIRALRGESFAVVAPPGLGKTTFGTIMSLFY-YM-K--------G-K----KSLMIFPTKTLVTQV---AQRLT-SM----SKN-------L-GS---------------TSPKLAYYY-SGL--TSSQKQ-EFITSLES-EDF-D------VLISTSRYIMKNIGN-I-EKY-------NYNYLFVDDVDSVLKS-SKSANVILRLVGFTD--NDVISV-------KELLKESR---N-------------------------N-YEE----AYEK-------I-----------SKIKEKKIK-----DK-------IA--IFSSAT--IT-KGN---PVFSSLMGFKPGSAVI-YLRNVIDSYVQ---------------------SDQDQ-ISLIN------------SLVQKLG-S---GGIIYVPVDKGIKY-------AKELASNIHQ---IKSAVITSNS------TSKLEKFESGEIDVLIGTATHYGILVRGIDLPWRVRYAIFAGIPKFQFKIG---------ET-MHPLAMLKMLTLISLV-S----------RNQDV-TRILRIVR-GRL--RNISTM---SLALLA-K--------DIK-EEK-----IN------------DK-YIEEAYKIVNKYLSDNSMLEKISEI-GEM---SI-----------NNG---YV-SVPDYLTYIQASGRTSRIFGGELTTGLSVVLV--DN--LKLFDLLKRRLS--LVLED-VSW------N-----------------NL--------DLNSWK------VGD----RNLDDILNKIDSERENISKI-KKEG
>AHC51187.1 reverse gyrase [Sulfolobus acidocaldarius SUSAZ]
--------------------------------------------------------------------------MQS------------------------------------LSDIPP---------------------------------------------SIYLFSCPNCGRSIST-YRLLLGSVCNIC-LED-DKEYKNIGD-----------------------------LIKDIEKQGNL-------I----KLK-DIQ--RVLDDYESFVSIFKRLL-GFPPFGPQKSWIYRLLSGESFAIIAPPGLGKTTFGLISSIYL-YL-R--------G-K----KSILVFPTKSLVRQA---IDKLS-SYIQNLAEI-------K-EN---------------P-PKVIYYY-SGM--SASERK-EADEGLQS-KIF-D------IFISTNRFLIDNIDQ-I-SST-------SYQFLFVDDVDTALKS-SKSAQAILKLLGFTP--NDQDKI-------KETLKKYR---ENTQ------------KN------EQN--EY----IFEE-------I-----------DKIRKDRLA-----SK-------TV--IFSSAT--LN-RSN---PILTSLVGFKPGSSVI-YIRKVYDMYVK---QPD---------------KEQET-FNLIK------------SLLHKLG-D---GGLIFVPVDKKQEY-------IKRLQSELSN--EFNVAAITSTS------ATKIDDFANGEIDVLIGSATHYGILVRGLDLPWRVKYSIFVGIPKFKFRLG---------EK-VNLLTLSRLLSLIALI-T----------KDQEV-IYISRRVK-DKI--RRLSPA---ALTMLS-V--------QAK-EGK-----LE------------DN-ILLKAYDLLNKYLSNQNVLKRISEI-GDF---VL-----------SPD--NDI-LIPDYLTYVQASGRTSRIYAGDVTTGLSVLLV--DD--FNLFRLLNKKLQ--YILDD-IQW------R-----------------EL--------DVEKWT------AGD----VEIKYLISKINEERNEISKL-KNEG
>WP_012022161.1 reverse gyrase [Metallosphaera sedula]
--------------------------------------------------------------------------MNA------------------------------------DERLPD---------------------------------------------VVYMGSCPNCGSDITS-VRLGKGSVCERC-LGE-EIDIGSLQQ-----------------------------LVEILQNAGTI-------K----SLL-REK--NILEEERKVIDLFKRVI-GSEPLGPQRSWIIRALRGESFPIIAPPGLGKTTFGIVMSLYY-AS-R--------S-E----KSLMIFPTRTLVSQV---VQKIQ-EM----GKS-------L-DF---------------T-PRLVYYV-SGL--TQSKKD-ELSKSLAE-EDF-D------IFISTSRYVIQHLDE-I-NKI-------NYKYLFVDDVDAVLKS-GKSSLTILKLMGFSD--ENVTKV-------RELLKTSR---D-------------------------N--TS----SFDE-------I-----------RKIRERFAK-----DR-------VA--IFSSAT--IT-RSN---PVFTSLMGFKPGGATI-YLRNVIDSYII----------------------GTDI-VSQTV------------ELVKRLG-P---GGLVFVPVDKGLNF-------AREISQKI-D--FLKASVVSSNT------TKKLEEFEQGSIDVLIGVATHYGLLVRGIDIPWRVRYAIFAGIPKFRFKLG---------ET-MHPLAMLRILTLLSVV-L----------KDPEI-TRILRFVK-YRL--RRTSTA---ALAMLA-K--------AVK-DGA-----LE------------DR-TMIRAYEIVNTYLKDKRIVEAISKF-GDI---SF-----------SGD---YI-SIPDYLTYIQASGRTSRLYGGHLTTGLSVLLV--DD--MILFDLLKKKLS--FILDD-MKW------N-----------------PL--------DLDSQK------IGD----RDLQEIVKQIDKERAEIIRR-RKIE
>WP_038061507.1 reverse gyrase [Thermodesulfobacterium commune]
---------------------------------------------------------------------------ML---------------------------------------------------------------------------------------YFLENGCPNCKGIVSD-ERLGKGIPCENC-LPE-GK-----------------------IPSNPSILK----ICEILEKEKTL-------K----QLK-IFG--EVEKQVSNFSKLFKEII-GAKPSSLQINWAKRLFLGESFAIIAPTGTGKSTFGLISALLT-P-------------K----KALIIVPTKMLVNQV---ETKLN-DF----IDR-------T-SSLALKKK------------RILAYT-GQ--------K-KEKEILEK-QNF-D------VFICTSAFMHKNFEI-L-K---SL----DFSLIFVDDVDSFLKS-SKNVDNLFLLLGFSE--EEIKLA-------LK---------------------------------RDK-TEE----DYSE-------L-----------LKIKKNHRS--------TQ--K-QL--IISSAT--LKPRTN-RVLLFQNLLGFEITRFVS-TLRKVIDTYL----DV----------GEPRDI--QRL-SEEAV------------KLIKALG-K---GGLVFVEESYGRTY-------VEKFTEQLREN-GVKAISYLEV--SE---EDLLNKLKQGEVEVAVGLCHLGNPLVRGLDLPEILRYAIFLGVPKHVFPLMKNEVSFSL-S--VAPQFLYSLLLSLMPL-F-KDD------ERITA-LSHVNYLR-RFL---------------------------TLR-EED-----LPK-------YEGLYK-KVLSIKEFIEERLKNPEFIEKLKTN-EEV---FLERDE-------NGN--YHL-IVGNASSYLQASGRVSRLTTKGLMPGLSVILV--DS--FKALNSLKKRLR-FYLGDE-VEL------T-----------------EV------------NF------E-------KIIELDTQIKQEREKIS----A-E
>RLG20638.1 reverse gyrase [Methanosarcinales archaeon]
------------------------------------------------------------------------MINTP---------------------------------------------------------------------------------------VVYKRSCPVCGEELTL-DEITRG----MC-R-T-G-------------------------------------------------------Y--------PLTKPFHMDVEYEFAQFFEERL-GLSISPLQRMWVRRLGRGESFTAVAPTGVGKTLFGLAYSAFL-AE-K--------G-K----RIYVIVPTTLLLQQS---VDRLR-EI--------------M-GV---N-------------GEVVFFH-GRM--RKKEKE-GALSRISS-GDF-R------ILLTTSAFLSKHFDI-I-ED--K-----IFDFIFVDDVDSILKA-SKNVDRILILLGLDN--DEH----------------------------------------------------------------------------------------------------G-IL--MVSTAT--SR-LGA-KAPLLRRLLGFGIGSPS--SITNVEHYSI----VKTN---------------------GDAE------------VITERMG-Y---GGLVFTQT---EEE-------ALRIAERLGD----RCGLVISS--RGRRVDELIESFLNREIDVLVGVCAPYGLLVRGLDYPLNIRYVVFMGAPMFNLGKE------GS-E---------KFIQSLK--------------------------TT-KSLP---------------------------------------------------------------------------------KDV---LL------------RD--GCV-LIPNIRTYLQAVGRTSRLMGSGMTKGISFVID--EA---EVLDVFERRAR--FH--D-VEFV----RK-----------------RV------------DE------I-------EYERLRRELEESR-------KE--
>HBF69716.1 reverse gyrase [Thermotoga sp.]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LLE-E-----------------------------SPSD----IYRALLERKTL-------K----EYR-FYH--DFWNEYEDFRSFFKKKF-GKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWL-AR-K--------G-K----KSALVFPTVTLVKQT---LERLQ-EF----ADEK--------------VK-------------ILGFY-SSM--KKEEKE-KFEKSFEE-DDY-H------ILVFSTQFVSKNREK-L-SQ--K-----RFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--EIIRKA-------FSTIKQGK--------------------------------------IYERP------------------KSLKP----------------G-IL--VVSSAT--AKPRGI-RPLLFRDLLNFTVGRLVS-VARNITHVRI----STRS--------------------KEKLI------------ELLEIFR-D---GILIFTQT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>WP_012718945.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MTS------------------------------------IDKVPP---------------------------------------------SIYTRSCPNCGGNISS-QRLFNGSVCESC-LKE-DKEFNNLSD-----------------------------LINILSENNTL-------K----NLI-QLY--NILEEYKKVEEIFSKLLNSSKPIGPQRSWIIRFLRGESFAIIAPPGLGKTTFGLIMSLYN-AI-H--------N-R----KSIIIFPTRTLISQT---IDKLA-KF----SES-------Y-SY---------------S-PRILY---NKQ--SSTQTE-NVLEQLKS-GDF-D------IFVSTSRYVIQNLSE-L-SNV-------KFDFIFVDDVDAALKS-GKSAKAILRLVGFTD--EDIQTT-------MKLLRENI---G-------------------------D--EE----KFGK-------I-----------QEIRENKLK-----DK-------IV--IFSSAT--IS-RGN---PTLSSLMGFRPGSSVI-YLRNIYDSYID---LTQTCK---------EQDVDECT-LGTVI------------RVLKRLN-D---GTLIFVPIDKGVQY-------AEYLASNLRDH-GINAESVASSS------ISKLEKFERGEVGSLVGVATHYGVLVRGIDLPWRVKYSIFVGIPKFKFKIG---------EY-MHPLALTRLLSLVYLV-K----------NDDKI-RGLLSYIR-KRL--RRISPA---ALAMLA-K--------DIR-EGK-----ID------------DE-RLKEAYSLVNEYLKDTEFLKKISSV-GDL---VI-----------EGD---YI-LMPDYLTYIQASGRTSRLYGANLTTGLSVLLI--DN--LRLFELLNKKLN--LILDE-VKW------Y-----------------PL--------DIDADR------LGQ----VSLSDIVTKITEERENLSKM-KKEG
>WP_012711665.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MTS------------------------------------IDKVPP---------------------------------------------SIYTRSCPNCGGNISS-QRLFNGSVCESC-LKE-DKEFNNLSD-----------------------------LINILSENNTL-------K----NLI-QLY--NILEEYKKVEEIFSKLLNSSKPIGPQRSWIIRFLRGESFAIIAPPGLGKTTFGLIMSLYN-AI-H--------N-R----KSIIIFPTRTLISQT---IDKLA-KF----SES-------Y-SY---------------S-PRILY---NKQ--SSTQTE-NVLEQLKS-GDF-D------IFVSTSRYVIQNLSE-L-SNV-------KFDFIFVDDVDAALKS-GKSAKAILRLVGFTD--EDIQTT-------MKLLRENI---G-------------------------D--EE----KFGK-------I-----------QEIRENKLK-----DK-------IV--IFSSAT--IS-RGN---PTLSSLMGFRPGSSVI-YLRNIYDSYID---LTQTCK---------EQDVDECT-LGTVI------------RVLKRLN-D---GTLIFVPIDKGVQY-------AEYLASNLRDH-GINAESVASSS------ISKLEKFERGEVGSLVGVATHYGVLVRGIDLPWRVKYSIFVGIPKFKFKIG---------EY-MHPLALTRLLSLVYLV-K----------NDDKI-RGLLSYIR-KRL--RRISPA---ALAMLA-K--------DIR-EGK-----ID------------DE-RLKEAYSLVNEYLKDTEFLKKISSV-GDL---VI-----------EGD---YI-LMPDYLTYIQASGRTSRLYGANLTTGLSVLLI--DN--LRLFELLNKKLN--LILDE-VKW------Y-----------------PL--------DIDADR------LGQ----VSLSDIVTKITEERENLSKM-KKEG
>WP_012736045.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MTS------------------------------------IDKVPP---------------------------------------------SIYTRSCPNCGGNISS-QRLFNGSVCESC-LKE-DKEFNNLSD-----------------------------LINILSENNTL-------K----NLI-QLY--NILEEYKKVEEIFSKLLNSSKPIGPQRSWIIRFLRGESFAIIAPPGLGKTTFGLIMSLYN-AI-H--------N-R----KSIIIFPTRTLISQT---IDKLA-KF----SES-------Y-SY---------------S-PRILY---NKQ--SSTQTE-NVLEQLKS-GDF-D------IFVSTSRYVIQNLSE-L-SNV-------KFDFIFVDDVDAALKS-GKSAKAILRLVGFTD--EDIQTT-------MKLLRENI---S-------------------------D--EE----KFGK-------I-----------QEIRENKLK-----DK-------IV--IFSSAT--IS-RGN---PTLSSLMGFRPGSSVI-YLRNIYDSYID---LTQTCK---------EQDVDECT-LGTVI------------RVLKRLN-D---GTLIFVPIDKGVQY-------AEYLASNLRDH-GINAESVASSS------ISKLEKFERGEVGSLVGVATHYGVLVRGIDLPWRVKYSIFVGIPKFKFKIG---------EY-MHPLALTRLLSLVYLV-K----------NDDKI-RGLLSYIR-KRL--RRISPA---ALAMLA-K--------DIR-EGK-----ID------------DE-RLKEAYSLVNEYLKDTEFLKKISSV-GDL---VI-----------EGD---YI-LMPDYLTYIQASGRTSRLYGANLTTGLSVLLI--DN--LRLFELLNKKLN--LILDE-VKW------Y-----------------PL--------DIDADR------LGQ----VSLSDIVTKITEERENLSKM-KKEG
>WP_028841534.1 reverse gyrase [Thermodesulfobacterium hveragerdense]
---------------------------------------------------------------------------ML---------------------------------------------------------------------------------------YFLENGCPNCKGMVSD-ERLSKGVPCEEC-LLE-ET-----------------------IPSSPSILK----VCQILEKEKTL-------K----QLK-VFG--EVEKQVSKFSKLFKEII-GAKPSSLQINWAKRLFLGESFAIIAPTGTGKSTFGLISALIT-P-------------K----KALIIVPTKMLVNQV---ETKLN-DF----IDR-------T-SFSSLKKK------------RILAYT-GQ--------K-KEKEILEK-QNF-D------VFICTSAFMHKNFEI-L-K---SL----DFSLIFVDDVDSFLKS-SKNVDNLFLLLGFSE--EEIKLA-------LK---------------------------------RDK-TEE----DYSE-------L-----------LKIKKQHRG--------TQ--K-QL--IISSAT--LKPRTN-RVLLFQNLLGFEITRFVS-TLRKVIDTYI----DV----------GEPKDI--QRL-SEEAV------------KLVKALG-K---GGLFFVEDSYGRTY-------VKKFTEQLREN-GVKAISYLEV--SE---EVLLTKLKQGEVEVAVGLCHLGNPLVRGLDLPEILRYAIFLGVPKHVFPLTKNEESFSL-S--IAPQFLYSLLLSLMPL-F-KDE------ERITA-LSHVNYLR-RFL---------------------------TLR-EED-----LPK-------YEGLHK-KILSIKEFIEERLKNPEFIEKLKTN-EEV---FLERDE-------NGN--YHL-IVGNASSYLQASGRVSRLTTKGLMPGLSVILV--DS--FKALNSLKKRLR-FYLGDE-VEL------T-----------------EV------------NF------E-------KIIELDTRIKQEREKIS----A-E
>WP_028950848.1 reverse gyrase [Sulfurihydrogenibium subterraneum]
--------------------------------------------------------------------------MIY---------------------------------------------------------------------------------------AVFEKLCPNCHGEISS-YRLEKGLPCKKC-LPD-E----------------------------D-LDV-----C------THV-------K--PGDIK-NLC--NLYDILKQWQEHFESYI-KAKPWNLQNTWAKRVLLRHSFVLLAPTGIGKTSFGISMASFL-A--K-------QG-K----KSYILLPTKLLVKQV---SERVK---------N-------F-GI---DKK------------DILAIGLEK---SNKEKE-ENKERLKN-GDF-K------ILITTSMFLYKNFEI-Y-P---RD-----FEFIFVDDVDSFVKT-AKNIDKALYLLGFTQ--DDIEKA-------LFFIKLK--------------------AK------PNK-TQE----DWDK-------I-----------NQLTEYLQK-QK--EK-IN--G-VL--IVSSAT--SKPRSS-RVKLFRELLGFEISSPTF-YLRNIVDSYD----EE------------------YS--FEKLI------------YWINRFG-K---GGLVFIPSDKGKEF-------VDEVVEKLNKH-KIKAVSYEEL--D----DKNLKKYQEGKIQVLVGISSYRNPLARGLDLPHVIRYALFYGVPKISISL-------RL-E--ENLVHMLWALTSIRSY-I-IK--KFPE-ITIKI-NQWITQLQ-KYQ---------------------------NLT-PDF-----IQN-------NPQVKE-KIENLQQEIREFFQKPEVLEVLKSS-DEI---VLK-QK-------EDG--YYL-IVSDATGYLQASGRTSRLYAGGITKGLSLILI--DE--KSAFKHLSKRVK--WFSED-IEF------I-----------------NI------------NQ------I-------ELDQLIRQIDQDREKVKNF-LT-N
>WP_014514041.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MTS------------------------------------IDKVPP---------------------------------------------SIYTRSCPNCGGNISS-QRLFNGSVCESC-LKE-DKEFNNLSD-----------------------------LINILSENNTL-------K----NLI-QLY--NILEEYKKVEEIFSKLLNSSKPIGPQRSWIIRFLRGESFAIIAPPGLGKTTFGLIMSLYN-AI-R--------N-R----KSIIIFPTRTLISQT---IDKLA-KF----SES-------Y-SY---------------S-PRILY---NKQ--SSTQTE-NVLEQLKS-GDF-D------IFVSTSRYVIQNLSE-L-SNV-------KFDFIFVDDVDAALKS-GKSAKAILRLVGFTD--EDIQTT-------MKLLRENI---V-------------------------D--EE----KFGK-------I-----------QEIRENKLK-----DK-------IV--IFSSAT--IS-RGN---PTLSSLMGFRPGSSVI-YLRNIYDSYID---LTQTCK---------EQDVDECT-LGTVI------------RVLKRLN-D---GTLIFVPIDKGVQY-------AEYLASNLRDH-GINAESVASSS------ISKLEKFERGEVGSLVGVATHYGVLVRGIDLPWRVKYSIFVGIPKFKFKIG---------EY-MHPLALTRLLSLVYLV-K----------NDDKI-RGLLSYIR-KRL--RRISPA---ALAMLA-K--------DIR-EGK-----ID------------DE-RLKEAYSLVNEYLKDTEFLKKISSV-GDL---VI-----------EGD---YI-LMPDYLTYIQASGRTSRLYGANLTTGLSVLVI--DN--LRLFELLNKKLN--LILDE-VKW------Y-----------------PL--------DIDADR------LGQ----VSLSDIITKITEERENLSKM-KKEG
>PMP74477.1 reverse gyrase [Aciduliprofundum sp.]
-----------------------------------------------------------------------------------------------------------------MDQNID---------------------------------------------YILLGSCPNCGGDINS-IRLTSGSCCIKC-IPD-DIKFENPMD-----------------------------MVLNLQRNGNL-------S----DLK-WLK--DNLEEYSTLERMFRDLL-GTPPLELQRSWIIRALRGESFAIISPPGTGKSTFGVIMSIYF-SM-K--------M-K----KTLAILPTRVLLEQM---AERIR-NF----SSK-------M-GL---------------N-VRVLLYH-SGI----RKKD-EILEKIEN-NDF-D------VLLITGRFAVKNYST-I-SKN-------RFSFFFIDDVDMALKS-SKSMEAILRIVGFRD--EDFSIL-------KN---RSY---N-------------------------E-GED----VFDR-------I-----------HKIRNERLN-----GK-------VA--VFSSAT--AS-RAL---PSFTALMGFRPGTPLV-FLRNVYDSY-----------------------SLEFS-DDFLI------------KAIKALG-P---GTLLFLPPDISSER-------GEEIERFLNVN-GIRASLVKSGK------ERSLSLFSEGKIDVLIGSAFQYGVLVRGIDMPERIKNAVFYGVPRFTFKVG---------ER-IPITLVPRMLSALSII-R----------GEKEL-SSLAVRIR-RRI--KKLSVS---GI-----R--------KIQ-SGE-----MEG-----------D---FEMAYRILGEAMMDEKTLNEISRL-AGF---VI-----------DNG---RI-MLPDPMTYIQGSGRTSRMYSGKLTTGISLVIV--DN--SSLFENFRKRVD--LFLED-TRW------L-----------------EF--------KPDDGM------IGE----MQIMDILKRMDDERKRISK----EG
>WP_029551795.1 reverse gyrase [Thermocrinis sp. GBS]
--------------------------------------------------------------------------MIK---------------------------------------------------------------------------------------AIFSKLCPNCGGDISS-ERLTKGLPCERC-LPV-V----------------------------E-HDL-----C------KSI-------K--DGSLK-SIC--NVEEELLEWMEEFKRGL-SASPWALQKTWAKRVLVGSSFALLAPTGVGKTSFGLSMVSFL-A--K-------KG-K----KSYVILPTKLLVEQT---VRKLK---------D-------F-GI---KEN------------EILFFG-DD---KNKEKE-EKKKRLVE-GQF-L------VLITTSMFLYKNYQI-I-P---KD-----FSFIFVDDVDSFLKT-AKNVDKALYLLGYTE--EDIELA-------LKLIKLK--------------------EK------PNK-SQE----DWDK-------I-----------RDYSKQLRE-IS--NQ-KA--G-VL--VVSSAT--SNPKSS-RIKLFRELLGFEVGTPTF-YLRNIVDAYE----DI------------------NA---LPLE------------EWIRKLG-K---GGLIFVPSDKGKEY-------VDLLKEELSFK-GISSLTYEEL--T----EENLRLFESGQVDVLIGIASYRNPLARGFDMPHVVRYALFYGVPKIVVSL-------KL-E--SNLSHLLWALSSIRSN-I-VK--KLPQ-LSQKL-DGWLSQLR-SYQ---------------------------YLT-EEF-----LSD-------KPELKA-KIDRLKAELEEFLRSEEVLSILRQS-EDV---SLR-VT-------EEG--YQL-VVSDVTGYLQASGRTSRMFAGGISKGLSLVLV--DD--KRAFNHLIKKVR--WFSED-IQF------V-----------------KV------------GE------I-------NLEELMQEIEKDRNLIREF-IK-S
>WP_009988760.1 reverse gyrase [Saccharolobus solfataricus]
--------------------------------------------------------------------------MTS------------------------------------INKVPP---------------------------------------------SIYTRSCPNCGGNISS-QRLFNGSVCESC-LKD-DREFSNLSD-----------------------------LINILSENSNL-------K----NLT-QIR--DVLEEYKKVEEIFGKLLNNSKPIGPQRSWTIRFLRGESFAIIAPPGLGKTTFGLIMSLYN-AT-R--------N-R----KSIIIFPTRTLISQT---VDKLA-KF----SEL-------Y-SY---------------S-PRILY---NKQ--SPTQTE-NILDQLKS-GNF-D------IFISTNRFVIQNLSE-L-SNI-------KFDFIFVDDVDAALKS-GKSAKAILRLVGFTD--EDIQTT-------MKLLRENI---G-------------------------E--EE----KFGK-------I-----------QEIRESRLK-----DK-------IV--IFSSAT--IS-RGN---PILSSLMGFRPGSSVI-YLRNIYDSYID---LTQTCK---------GQDFEECT-LGTVI------------KLLKRLN-D---GTLIFVPIDKGAQY-------ADYLASNLRDH-GINVESVASSS------ISKLEKFERGEVSSLVGVATHYGVLVRGIDLPWRVKYSIFVGIPKFKFKIG---------EY-MHPLALTRLLSLVYLV-K----------NDDKV-RGLLSYIR-KRL--RKISPA---ALAMLA-K--------DIR-EGK-----ID------------DE-RLKEAYNLVNEYLKDNEFLKKVSDV-GDL---VI-----------EGD---YI-LMPDYLTYIQASGRTSRLYGANLTTGLSVLLI--DN--SRLFELLNKKLN--LILDE-VKW------Y-----------------SL--------DIDADK------LGQ----VSLSDISAKITEERESLSKI-KKEG
>RMH81326.1 reverse gyrase [Acidobacteria bacterium]
--------------------------------------------------------------------------MID---------------------------------------------------------------------------------------SVFKGLCPNCGGDITS-NRLELGIPCERC-MPD-----------------------------------------------GEV-------L-VEGELL-RLK--RVEAKVREWEAFFEERI-GFSPWSLQVSWAKRILLGHSFALLAPTGVGKSSFGLSMATFL-A--R-------EG-K----RSYIILPTRMLVEQT---VRKLY---------S-------M-GL---SHD------------DLLYFG-DE---TSKRKE-IKKERLLR-GDF-K------VLVSTSMFLYKNQDS-I-P---KD-----FDFIFVDDVDSFLKT-AKNVDKVLYLLGFLE--DDVELA-------MKVIRLK--------------------EA------RNK-EEK----DWKD-------I-----------KELSEELRR-RS--KK-TG--G-VL--VVSSAT--SSPRSS-RIKLFRELLGFEVGMPTF-YLRNVVDLYT----PL------------------NQ---KTVE------------KWVKKLG-K---GGLIFVSSDLGKDQ-------VDRVVNELRSK-DIKAVSYEEL--N----EEVLRKYEEGEIDVLVGIASYRNPLARGFDMPHAVRYALFYGVPKMVISL-------KF-E--KSLSHLLWALASVRSL-L-AK--NMPS-KIKEV-DRWLEQLK-RYQ---------------------------YLS-EEY-----LST-------KPELQK-KVDSLRESIGEFLSSEDVLRLIETS-EEI---SLR-KT-------PEG--YVM-VLSDATGYLQASGRTSRMFAGGISKGLSLTLV--DD--QRAFKHLQKKVR--WFNEE-LNF------K-----------------SL------------EE------D-------ELKEILFQIDQNREKIKRL-IK-G
>OYT51958.1 reverse gyrase [Desulfurococcales archaeon ex4484_217_2]
--------------------------------------------------------------------------MK--------------------------------------GKLEC----------------------------------------EYMIPAIFKGLCPNCGSDITS-ERLEKSLPCEKC-LPN-PELK-YPVI----------------KGFLVK-----------------------------------VW--DVEEHVNEINKLFVKAI-GSKMWGLQRLWARRFLNGESFAMVAPTGSGKTTAQIIFGLYASAN-Y--------G-K----RVLILLPTSLLVHQV---QNKVI-EI----RSK-------L-EL--DSVK-------------VAAYH-SLL--SEKQKQMELASMD----EA-S------IIITTPISL-MKREE-LQQK---------IDVAFIDDVDSFLRR-SKSVDVVLKMLGVSP--EEIALI-------EEAQKMES---TAR---KLSRDS------------PEE-ARE----LLRK-------A-----------SELKRKVRENVK---------G-QI--VVSGAT--QTARRTKRVRLLSSLFGFTVGGKVE-VGRNIVDTYV----KPSF-----------------SV-EEEVT------------NIVTKLG-G---GGLIYVPMDRGAEY-------VKKLTEYLKER-GVNAEAYLGA---R---KRVFEKYVAGDIDVLVGIASYRSPLTRGIDLPERVRYAVFAGVPKFRIRI-------SV-DE-FQPSRWLILLNEIKDV-V-YDK------YPRMF-DRVLGGLI-RV---RTATRD---VLEQVR-K--------ALA-ENE-----TLE-GY----PEFVRR-VAKETLDFLLTVLKDEEVLEKLKKS-PTI---TFG-GK-------EGE--YFF-IIPDATAYIQASGRTSRLYVGGLTKGLSVIVI--DE--EKAFNSLLKDLK--WLLET-VQF------Y-----------------KL------------DD------V-------DLEKILKEIDDDRRKVRLA-IE-G
>WP_069806403.1 reverse gyrase [Vulcanisaeta thermophila]
--------------------------------------------------------------------------MRPVR-------------------------------------EP-------------------------------------------TV--LYKGACPNCGGDILS-DRLAMGLPCNKC-LPE-PSHG---------------------RVDINGVIE----ALN---KLGTI-------N----RLR-AME--RLAREYEYVSELFSKVV-GSRMWGAQRLWARRLIKGKSFAIVAPTGSGKTTFGIIASIYT-AT-R-------LG-G----KVLIVLPTSTLAYDV---YRRFL-NY----LGK-------A-GV---NLR-------------VVLAS-SIL--GKQEVE-ASMNAINT-GNF-D------VLIVTNAFLPRNMNI-L-SK--Y-----RFSLIFVDDVDSVLKASSKNIDRLLLLLGIDN--DALNKA-------LRVVDLMK---KLT---KAIRFR----AS------EEE-ISK----LRAE-------I-----------KQLNDELSRYVS--EN--R-IG-IL--IASGAL--TRMRRTARLFLFRRFLGFETGGKAE-GLRNVVDVYV----KPRG-----------------DI-IDEVV------------SIVRRLG-D---GGIIYLPPDM-KDL-------AEAINNKLNEN-GIKSSLYLKP---K---KSVLEDFLNGKIDVLIGLATSRSSLVRGIDLPQRIAYVVFVGVPRIRFRV-------NV-EE-FTPMKYLMLLFNIRNV-V-PQY------LRNDI-DRVIVRLR-NISA---LNQE---QLSRIL-K--------ALE-NNE-----KLE-GF----EAYAAD-VIKESLDLVNKLLRDPSIRSAIEKS-ADV---GLE-YI-------NNE--LYI-VIPDSTTYIQGSGRTSRLYVGGISRGLSVLIV--DN--EKVFNGLIKNLR--YRLED-VKL------Q-----------------SI------------DE------V-------NIDELIREIKSERALIRDI-IE-G
>BAN90317.1 reverse gyrase [Aeropyrum camini SY1 = JCM 12091]
--------------------------------------------------------------------------MAS-------------------------------------G--------------------------------------------WAVSRGVYRYLCPNCGGPNTE-ERLSQGLPCPRC-LPS-IPGR-RVSS--------------------------WSGLARLLKREGTL-GA-G-VK--------AIA--SLEDEARSLWRFFEKAV-GSPPWGAQRTWAKRLARGDSFSIIAPTGVGKTTFGAAAALFY-AC-R-------KG-M----RSYIILPTTTLAANV---AKKLE-SM----VES-------T-GC--RKAR-------------ILVIH-SKL--KAAERR-EALERFEN-GDF-D------ILVTTAAFARKYVDK-L-SG--Y-----RFRLVFVDDVDAVLRS-ARSVDAILRIVGFDE--EAIETG-------LEVLRLQREQARLV---SLLQSP------------REE-VRE----EARKK------LLEVKRRL----ESLEAEIEA-----KR-KG-TA-SL--IVSSAT--GRPRGA-RVRLFRVLLNFEAGGRGDIGLRRVVDSYT----YPQDGV------------------TERVV------------ELVKTLG-T---GGLVYVPIDMGVEY-------AEKLAEDLRRA-GVKAEAYHAK--KP---LELLDRFAEGEIDVLVGVANYYGTLVRGIDLPARVRYAVFAGVPRHKFGS-------DI-GD-PHPSRLLRLLSILAESRI--EE------VASAA-RSHMGRLR-RIL--RLLSPA---ALQMIA-E--------RVA-RGE-----VEG-GY--------DK-QVLDAYNFLREALRRDDVWESLREL--DV---GVV-RE-------GGR--TYI-LVPDPATYLQASGRTSRLYAGGITLGLSVVVV--DN--EAVLRGLMKRVS--WMAE--VEW------R-----------------RL------------ED------L-------DLHAVIREIDEDREKVRKV-VK-G
>RUM30178.1 reverse gyrase, partial [Aquifex sp.]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WAKRVFMNQSFAIVAPTGVGKTTFGLVMSLFL-K-------------G----KVLAIFPTRLLAQQA---GERLS-EL----AQK-------V-GV----SK------------KILVYQ-SK--------K-KIREQFLN-GDW-D------ILLGTNMFLHKNFEN-L-I---NF----KFKLIFIDDIDSFLKK-GKNVDYLFKLLGFTE--EEIKLA-------LK---------------------------------ENK-TQR----DYDR-------L-----------AKIRKR--K--------RD--T-VL--IVSSAT--LKPRGK-RAYLFRNLLGFDVQKAIT-TLRNIVDVAE----SVSS---------------LEEA-LEKSV------------DLIKKLG-K---GGLVYLSVFYGKDK-------VQEVKEYYRKH-GINAISYLDY--KP---EELYQILEKGKFDVAVGISHITNPLVRGIDLPHIIRYAVFLDPPKHVFPT-------EL-S--LNPPLLHGLLLTLLNL-F-EGD------DRLKA-IQYVSYLK-RYL---------------------------TLR-EEQ-----LDN-------YPRIKE-RVEEIKNFLEKYLKDEKFLKKVEES-EDI---SLV-PK-------EGK--LYI-VVGDANSYIQASGRTSRFIAGGMTKGLSVLYY--SD--PKAFYSLKKRLSLYYMTQE-VEF------K-----------------RL------------SE------I-------DLNKLIKEIDEDRKRARAI-LE-G
>ESQ21773.1 reverse gyrase [uncultured Acidilobus sp. CIS]
-------------------------------------------------------------------------MPR--------------------------------------------------------------------------------------IEAVFRRLCPNCHGEITA-SRLAKGLPCSTC-LPE-EPEQADPI-------------------------S----IGETLQKLGRY-------G----SYL-ELS--YLERDYRDFSGYFEDKY-GFAMSSAQRSWARRLLLLDSFSIVAPTGVGKTTLLMAYAAYR-AE-K-------DK-W----RVLYLVPTENLVAQT---ADRVS-KI----VGA-------G-S--------------------VAYYY-SSM--KAEDRQ-AMMERIKG-RDY-L------VLVITPGFMVRSFDV-L-RA--AA----PYNLAIVDDVDSLLRN-SKNIDRTLMLLGFSE--EVISTA-------FRLVQLRL---DLAG-ALKAGHR-------------ER-AEQ----LTKE-------I-----------ASLSLQLQ--QSE----VQ-QG-QL--VIASAT--GKPRGV-KHLVFRELLGFEVGGGTD-YLRNVIDSYH----ISDDV-------------------MASIA------------ELAQRLG-R---GGLIFVSQAYGKSM-------VKVVAEALNKA-GVRAVHAISNP------RRAVEKLVSGEADVAVGVASRYGALVRGIDLPEVIRYALFLGVPAIKLDLRT-----AL----LSPRRLLRVLMFAE-----EK-------------DKSFSDYR-KRL--EALLRSYAVDSRIMA---------AVIR-GQL-----EAK-GRLEELRKLVLE-ASERVVNLLEGLLQSEG--QTIRIG-T-M---VI--RR------ESGS--LWL-YSPDAPSYIQASGRTSRLFHGSMTRGLSVIID--RM--PELVDALQDRLR--WLSQA-Q-F------V-----------------PF------------GS------L-------DLKSVEKELEASRKEP-----E-A
>Q9YC75.2 RecName: Full=Reverse gyrase 2; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Aeropyrum pernix K1]
------------------------------------------------------------------------MPGG--------------------------------------------------------------------------------------VNAVYMGLCYNCGGNIDE-DRLEKGLPCARC-LPS-PPRRATPL-------------------------T----VYRALKKAGTL-------G----AYS-WEY--LSIREVERFEAYFAAKS-GSRLWSAQRSWAKRLVKGDSFAIIAPTGVGKSTLLTVYAAYV-AA-V-------KR-G----RVLYLVPTENLVRQV---YAKLD-Q-----VEP-------G-I--------------------ATAYY-SRM--PAKARE-SSLEKIAS-GGA-R------LIVATTGFLSRRFDL-L-HP--QY----KFDLAIVDDVDSLLRN-SRNVERILLLTGFSE--ETVEAA-------HSLVKARL---KLYR-ALH-SGAS-----------ESI-VSR----LEQE-------I-----------AQLEARLRLSLSE----AS-PG-QL--VIASAT--GRPRGV-KHLLFKELLGFEVGGGSD-YLRNIVDAYV----VDSDP-------------------VGRTA------------EIVSALG-D---GVIVFVSQRLGKDV-------ARAIAGRLEGM-GVSTALALTGA------RRPVEAFARGEARVLIGMASRYGVIVRGLDLPERSKYAVFLGAPSAKTHLLE-----AL----YSPRRMLAFLSIAQ-----EKG------VE--WAGEAFRRLS-RLL--EKVI-----DTSIVS---------LAAR-GKL-----EAQ-GPAGEAAGIISE-TAPRLVDWLVAEARLQG--GLLRVG-G-L---VV--DA------RGPI--PYL-VVPDAPTYIQASGRVSRLYRGVMTRGLSIVVD--EA--PEYVEALGERLK--WTTSS-R-L------R-----------------PL------------SE------V-------DMEKLRREIEESRR---------G
>ADX83008.1 reverse gyrase [Sulfolobus islandicus HVE10/4]
--------------------------------------------------------------------------MTS------------------------------------IDKAPP---------------------------------------------SIYTRSCPNCGGNISS-QRLFNGSVCESC-LKE-DKEFNNLSD-----------------------------LINILSENNTL-------K----NLI-QLY--NILEEYKKVEEIFNKLLNSSKPIGPQRSWIIRFLRGESFAIIAPPGLGKTTFGLIMSLYN-AI-R--------N-R----KSIIIFPTRTLISQT---IDKLA-KF----SES-------Y-SY---------------S-PRILY---NKQ--SSTQTE-NVLEQLKS-GDF-D------IFVSTSRYVIQNLSE-L-SNV-------KFDFIFVDDVDAALKS-GKSAKAILRLVGFTD--EDIQTT-------MKLLRENI---V-------------------------D--EE----KFGK-------I-----------QEIRENKLK-----DK-------IV--IFSSAT--IS-RGN---PTLSSLMGFRPGSSVI-YLRNIYDSYID---LTQTCK---------EQDVDECT-LGTVI------------RVLKRLN-D---GTLIFVPIDKGVQY-------AEYLASNLRDH-GINAESVASSS------ISKLEKFERGEVGSLVGVATHYGVLVRGIDLPWRVKYSIFVGIPKFKFKIG---------EY-MHPLALTRLLSLVYLV-K----------NDDKI-RGLLSYIR-KRL--RRISPA---ALAMLA-K--------DIR-EGK-----ID------------DE-RLKEAYSLVNEYLKDTEFLKKISSV-GDL---VI-----------EGD---YI-LMPDYLTYIQASGRTSRLYGANLTTGLSVLVI--DN--LRLFKLLNKKLN--LILDE-VKW------Y-----------------PL--------DIDADR------LGQ----VSLSDIITKITEERENLSKM-KKEG
>RKX61159.1 reverse gyrase [Thermodesulfobacteria bacterium]
---------------------------------------------------------------------------ML---------------------------------------------------------------------------------------FYLINCCPNCGGNISD-ERLFKGLPCEKC-LPN-PE------------------------LSHINVNQ----VCNSLKKQNFI-------K----NLK-PYC--EVEKKVEEFKNIFYEIL-NTAPSSLQISWAKRLFLGESFAIVAPTGTGKTTFGLISSLLT-S-------------K----KALIIVPTKVLVNQV---EERLL-FY----QEK-------I-KNPEIKYK------------RILAYK-GH--------T-KEKKILES-GNF-H------VFICTSAFLHKNFEI-L-K---SL----DFSLIFVDDVDSFLKN-SKNVDNLFLLLGFTP--KEIQLA-------LK---------------------------------KDK-EHT----DYDL-------L-----------LKIKEKHST--------KL--K-QL--IISSAT--LKPKTN-RVLLFQNLLGFEITRFVS-TLRKVVDTYI----PVNLDN----TSSSNKELIFEKL-LETSA------------KLISQLK-D---GGLIFVEENFGRKY-------VEIATQYFRNK-GFKVLSYLEA--NE---EKLLNALKIKEIDIAVGLSHLSNPLVRGVDLPEILKYAIFLGVPKHLFPLFSTKEKFDL-P--ISPQFLYNLLLTLMPL-F-EEE------EKFTA-LSYINYLK-KYL---------------------------TLK-EET-----LSK-------YETLYK-KILSIKEFLENKLNDKEFIKKIEKS-DEV---FLEKDE-------NGQ--YYV-VVGNANVYLQASGRVSRLTTRGLLPGLSIILA--EN--LKALNSLKKRLR-FYLKDE-AEI------K-----------------LI------------SE------N-------EVKEIYEKIIQERQKIT----K-E
>WP_015418886.1 MULTISPECIES: reverse gyrase [Hydrogenobaculum]
--------------------------------------------------------------------------MIE---------------------------------------------------------------------------------------AIFKNLCPNCGGDISS-YRLAKGLPCEKC-LEE-E------------------------------SEN----VC------DVL-------K--EGLLK-ERC--DIEKELNSWEEYFYKYT-NLKPWALQKTWAKRVFLKESFSLIAPTGIGKSSFGISLAAFL-S--T-------RN-K----KSYVLVPTKLLLKQT---FDRLL---------S-------F-GV---KEE------------DILIFGLDA--------K-KDKSLLKA-QNY-K------ILITTNMFLYKNEEL-I-P---RD-----FDFIFVDDIDSFLKT-AKNIDKLLYIMGFEK--DIIDKT-------FELLKLK--------------------SF------FRK-NE-------TK-------L-----------KAISQEINDYLS--TQEQK--T-VL--VLASAT--SKPKSK-RVLVFKELLGFELSTPTY-YLRNITDTFD----EP---------------PSYKLD-YKTLI------------KYINTFG-K---GGLVFVSAEKGKDT-------IKEIIETLNKN-HIKAISYEDI--K----EDDIKAYENGDIDVLVGIASYRNPLARGIDLPHVIRYAVFYGVPKIEIPL-------SL-D--AKINHLVMALLSIKNI-F-IN----TE-HYQTI-SELIEQLN-RYR---------------------------YVK-EE--------------------ND-VVKNLKQKAKEFFSQRDIIEKIENS-KDI---TLK-KQ-------NDK--YYI-LIPDINGYIQASGRTSRLYAGGISKGLSVVLV--DD--KATFESLKKKLL--WLG-D-IKF------E-----------------NI------------KD------V-------DIQSILKAIDQDRENLRAF-IK-K
>WP_059176220.1 reverse gyrase [Thermodesulfovibrio aggregans]
--------------------------------------------------------------------------MIL---------------------------------------------------------------------------------------SLFKGLCPNCGGEIAS-QRLDKGLPCEKC-LPN-E----------------------------E-DDP-----C------SFI-------K--SGNYK-EVC--LVKEYVQKWEKNFEKYV-KSKPWSLQKTWAKRVFSGVSFALLAPTGVGKTSFGISMASYL-A--K-------LN-K----KSYIIVPTKLLVEQV---SERLK---------N-------F-GL---KDE-------------ILGFV-ET---NEKLKE-----RLKK-GDF-Q------VLVTTSMFLYKNQEI-I-P---PD-----FSFIFVDDVDSFLKT-AKNVDKVLYLLGFSS--SEIKKA-------LEVIALK--------------------AK------VKK-TDA----DWEK-------I-----------NEIQKELYS-LR--NT-KK--G-VL--VVSSAT--SQPRSN-RIKIFRELLGFEVGTPTF-YLRNVIDTFT----E-----------------------KGSLV------------GWIKRLG-K---GGLIFISSDKGKEK-------IDEIIKELKKN-GIEAVSYENL--N----DRAISNFEKGRIDVLVGIASYKNPLARGFDMPQVVRYAIFYGVPKIVISL-------KF-E--SNLSHLLWAVSSIRSF-I-VK--KMPK-YTQKI-NSWINQLR-KFQ---------------------------YLA-EDF-----INL-------KPSLKQ-TIDNLREQIGDFFSSKEVLDLLNSS-DEI---TLR-FT-------EEG--YMM-VVSDATGYLQASGRVSRMYAGGITKGLSLVLV--DD--TATFKHLLRKVK--WFSDE-IKF------L-----------------PV------------EE------I-------DLSSVLKEIDEDRAKIKEF-LM-T
>WP_015581309.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MTS------------------------------------IDKVPP---------------------------------------------SIYTRSCPNCGGNISS-QRLFNGSVCESC-LKE-DKEFNNLSD-----------------------------LINILSENNTL-------K----NLI-QLY--NILEEYKKVEEIFNKLLNSSKPIGPQRSWIIRFLRGESFAIIAPPGLGKTTFGLIMSLYN-AI-R--------N-R----KSIIIFPTRTLISQT---IDKLA-KF----SES-------Y-SY---------------S-PRILY---NKQ--SSTQTE-NVLEQLKS-GDF-D------IFVSTSRYVIQNLSE-L-SNV-------KFDFIFVDDVDAALKS-GKSAKAILRLVGFTD--EDIQTT-------MKLLRENI---V-------------------------D--EE----KFGK-------I-----------QEIRENKLK-----DK-------IV--IFSSAT--IS-RGN---PTLSSLMGFRPGSSVI-YLRNIYDSYID---LTQTCK---------EQDVDECT-LGTVI------------RVLKRLN-D---GTLIFVPIDKGVQY-------AEYLASNLRDH-GINAESVASSS------ISKLEKFERGEVGSLVGVATHYGVLVRGIDLPWRVKYSIFVGIPKFKFKIG---------EY-MHPLALTRLLSLVYLV-K----------NDDKI-RGLLSYIR-KRL--RRISPA---ALAMLA-K--------DIR-EGK-----ID------------DE-RLKEAYSLVNEYLKDTEFLKKISSV-GDL---VI-----------EGD---YI-LMPDYLTYIQASGRTSRLYGANLTTGLSVLVI--DN--LRLFKLLNKKLN--LILDE-VKW------Y-----------------PL--------DIDADR------LGQ----VSLSDIITKITEERENLSKM-KKEG
>RLG13082.1 reverse gyrase [Candidatus Pacearchaeota archaeon]
---------------------------------------------------------------------------ML---------------------------------------------------------------------------------------FYLINCCPNCGGNISD-ERLFKGLPCEKC-LPN-PE------------------------LSHINVNQ----VCNSLKKQNFI-------K----NLK-PYC--EVEKKVEEFKNIFYEIL-NTAPSSLQISWAKRLFLGESFAIVAPTGTGKTTFGLISSLLT-S-------------K----KALIIVPTKVLVNQV---EERLL-FY----QEK-------I-KNPEIKYK------------RILAYK-GH--------T-KEKKILES-GNF-H------VFICTSAFLHKNFEI-L-K---SL----DFSLIFVDDVDSFLKN-SKNVDNLFLLLGFTP--KEIQLA-------LK---------------------------------KDK-EHT----DYDL-------L-----------LKIKEKHST--------KL--K-QL--IISSAT--LKPKTN-RVLLFQNLLGFEITRFVS-TLRKVVDTYI----PVNLDN----TSSSNKELIFEKL-LETSA------------KLISQLK-D---GGLIFVEENFGRKY-------VEIATQYFRNK-GFKVLSYLEA--NE---EKLLNALKIKEIDIAVGLSHLSNPLVRGVDLPEILKYAIFLGVPKHLFPLFSTKEKFDL-P--ISPQFLYNLLLTLMPL-F-EEE------EKFTA-LSYINYLK-KYL---------------------------TLK-EET-----LSK-------YETLYK-KILSIKEFLENKLNDKEFIKKIEKS-DEV---FLEKDE-------NGQ--YYV-VVGNANVYLQASGRVSRLTTRGLLPGLSIILA--EN--LKALNSLKKRLR-FYLKDE-AEI------K-----------------LI------------SE------N-------EVKEIYEKIIQERQKIT----K-E
>PMP62497.1 reverse gyrase [Sulfurihydrogenibium sp.]
------------------------------------------------------------------------MNTIP---------------------------------------------------------------------------------------SIFEKLCPNCYGEISS-YRLEKGLPCEKC-LPD-E----------------------------N-LEV-----C------QYI-------K--EGGIR-ELC--DIKQELKEWQEHFEKHI-NSLPWSLQNTWAERVFLKHSFVLLAPTGIGKTSFGISMASYL-S--K-------QG-K----RCYILLPTKLLVKQV---YERVK---------N-------F-GV---DEK------------DILAIGLEK---NSKEKE-ENKERLKN-GKF-K------ILITTSMFLYKNFDI-Y-P---KD-----FDFIFVDDVDSFVKT-AKNIDKALYIMGFSE--DDINKA-------LELIKLK--------------------GK------PNK-TQE----DWNK-------I-----------KELTEYTAK-QR--EK-IK--G-VL--IVSSAT--SNPKSS-RVRLFRELLGFEISTPTF-YLRNIVDSYD----EE------------------YS--FEKLV------------SWIKTLG-N---GGLVFIPSDKGKEF-------VDEVVEKLNKQ-KIKALSYEEL--D----DKNLKKYENGKIQVLVGISSYRNPLARGLDLPHVIRYALFFGVPKIAISL-------RL-E--ENLSHMLWALTSIRRY-I-VK--AFPE-ITLKI-NQWITQLQ-KYQ---------------------------YIT-PEF-----LQD-------KPQLKE-KIDNLQKEIAEFLQKPEVIQSLKSS-DEI---TLK-QK-------EDG--YYL-IVSDATGYLQASGRTSRLFAGGITKGLSIVMI--DE--KSAFNHLIRRVK--WFSED-IDF------V-----------------DI------------KQ------V-------NIPQIIEQIDKDRELVRRF-LQ-K
>Q9YCB6.2 RecName: Full=Reverse gyrase 1; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Aeropyrum pernix K1]
--------------------------------------------------------------------------MAS-------------------------------------A--------------------------------------------RAASRGVYRYLCPNCGGPNSE-ERLSRGLPCPRC-LPR-LPRK-GVSG--------------------------WTGLARLLRREGTL-GA-G-VK--------AMA--SLEEEARSLWRFFEKAV-GSPPWGAQRTWAKRLARGDSFSIIAPTGVGKTTFGAAASLFY-AC-K-------KG-M----RSYIVLPTTTLAANV---ARKLE-SM----VES-------T-GC--GRVR-------------LLVIH-SKL--KTSERR-EAMERFEK-GDF-D------ILVTTAAFARKYADR-L-SG--Y-----RFRLVFVDDVDAVLRS-ARSVDAILKIVGFDE--EAIEKG-------LEVLRLQREQARLV---GLLQSQ------------REE-VRE----EARKK------LLEVKRRL----ERLEAEIEA-----RR-GR-TA-SL--IVSSAT--GRPRGA-RVRLFRVLLNFEAGGRGDIGLRRVIDSYT----HPTDGV------------------AEKVV------------ELVRRLG-T---GGLVYVPIDMGVEY-------AERLAEELRRA-GVKAEAYHAK--KP---LELLDRFAEGEIDVLVGVANYYGTLVRGLDLPARVRYAVFAGVPRHKFGS-------DI-GD-PHPSRLLRLLSILAESRI--EE------VASAA-RSHMGRLR-RML--RVLSPA---ALQMIA-E--------RVA-RGE-----VEG-GY--------DR-QVLEAYQFLREALARDDVWESLREL--DV---GIV-RE-------GGR--TYI-LVPDPATYLQASGRTSRLYAGGITLGLSVVVV--DN--EPVMRGLMKRVS--WMAE--VDW------R-----------------RF------------ED------L-------DLQSILREIDEDREKVRRV-VK-G
>WP_110369237.1 reverse gyrase [Metallosphaera hakonensis]
--------------------------------------------------------------------------MIA------------------------------------DELLPD---------------------------------------------VVYMDSCPNCGSDITS-IRLGNGMVCEKCIIKD-DVLVKDLHD-----------------------------LIDLLDRQGTL-------R----MLR-QVK--EILYEEKKVNEIFQRIV-GSNPLGPQRSWIIRALRGESFAIVAPPGLGKTTFGIIMSLYY-AS-M--------Q-E----KSLLIFPTKTLVSQV---VQKIQ-EM----GKV-------L-NP---------------P-PRLMYYM-SGM--SQSKKD-ELVKSLKE-GDF-D------ILVSTSRYVIDHLDE-I-NRI-------NYKYLFVDDVDAVLKS-GRSSLTILKLMGFTE--DNVREV-------KELLKTAR---D-------------------------D--VS----SFEK-------I-----------RKIRENFQR-----NR-------IA--VFSSAT--IT-KSN---PVFSSLMGFKPGGSTI-YLRNVIDSFVE----------------------TDNI-LEKTV------------EIVQRLG-A---GGLVFVPIDRGLAF-------AKEISDRL-A--SVKASVVSSNT------TRKLEDFENGSLDVLVGVATHYGLLVRGIDLPWRVRYAVFAGIPKFRFKLG---------ET-MHPLAMLRILTLLSVV-L----------RDPEV-TRLLRFVR-LRL--RRTSSA---ALAMLA-K--------SVK-DGT-----LE------------DR-TIAKAYDIVNRYLKEKNIVEAISKF-GDI---SF-----------SGE---YI-SMPDYLTYIQASGRTSRLYGGHLTTGLSVLLV--DD--SFLFTLLKKKLS--FILDE-MNW------S-----------------LF--------DLEREK------VGD----RELSEVIKQIDAERSEIIKR-KSLG
>GBF09021.1 reverse gyrase 2 [Aeropyrum pernix]
------------------------------------------------------------------------MPGG--------------------------------------------------------------------------------------VNAVYMGLCYNCGGNIDE-DRLENGLPCARC-LPS-PPRRVTPL-------------------------T----VYKALKKAGTL-------G----AYS-WEY--LSIREVERFESYFAAKS-GSRLWSAQRSWAKRLVKGDSFAIIAPTGVGKSTLLTVYAAYV-AA-V-------KG-G----RVLYLVPTENLVRQV---YAKLD-Q-----VEP-------G-I--------------------ATAYY-SRM--PAKARE-SSIEKIAS-GGA-R------LIVATTGFLSRRFDL-L-HP--RY----KFDLAIVDDVDSLLRN-SRNVERILLLTGFSE--ETVEAA-------HSLVKARL---KLYR-ALH-SGAS-----------ESI-VSR----LEQE-------I-----------AQLEARLRLSLSE----AS-PG-QL--VIASAT--GRPRGV-KHLLFKELLGFEVGGGSD-YLRNIVDAYV----VDSDP-------------------VGRAA------------EIASALG-D---GVIVFVSQRLGKDV-------ARAIAGRLEGM-GVSTALALTGA------RRPVEAFARGEAQVLIGMASRYGVIVRGLDLPERSKYAVFLGAPSAKTHLLE-----AL----YSPRRMLAFLSIAQ-----EKG------VE--WAGEAFRRLS-RLL--EKVI-----DTSIVS---------LVAR-GKL-----EAQ-GPAGEAAGIISE-TAPRLVDWLVAEARLQG--GLLRVG-G-L---VV--DA------RGPI--PYL-VVPDAPTYIQASGRVSRLYRGVMTRGLSIVVD--EA--PEYVEALGERLK--WTTSS-R-L------R-----------------PL------------SE------V-------DMERLRREIEESRR---------G
>ESQ22836.1 reverse gyrase [uncultured Acidilobus sp. MG]
-------------------------------------------------------------------------MPR--------------------------------------------------------------------------------------IEAVFRRLCPNCHGEITA-SRLAKGLPCSTC-LPE-EPEQADPI-------------------------S----IGEALQKLGKY-------G----SYL-ELS--YLERDFRDFSGYFEDKY-GFAMSSAQRSWARRLLLLDSFSIVAPTGVGKTTLLMAYAAYR-AE-K-------DK-W----RVLYLVPTENLVAQT---ADRVS-KI----VGA-------G-S--------------------VAYYY-SSM--RAEDRQ-AMMERIKG-QDY-L------VLVITPGFMVRNFDV-L-RA--AA----PYNLAIVDDVDSLLRN-SKNIDRTLMLLGFSE--EAISTA-------FRLVQLRL---DLAG-ALKAGHR-------------ER-AEQ----LTKE-------I-----------ASLSLQLQLKQGE----AQ-QG-QL--VIASAT--GRPRGV-KHLVFRELLGFEVGGGTD-YLRNVIDSYL----VSNDA-------------------MASII------------ELAQGLG-R---GGLIFVSQAYGKSM-------VKVVAEALNKA-GVRAVHAISNP------RRAVEKLVSGEADVAVGVASRYGALVRGIDLPEVIRYALFLGVPAIKLDLRT-----AL----LSPRRLLRALMFAE-----EK-------------DKSFSDYR-KRL--EALLRSYTVDSRIIA---------AVIR-GQL-----EAR-GRLEELRKLVLE-ASESVVNLLEGLLQSEG--QTIRIG-T-M---VI--RR------ESGS--LWL-YSPDASSYIQASGRTSRLFHGSMTRGLSVIID--RI--PELVDALQDRLR--WLSQA-Q-F------V-----------------PF------------KS------L-------DLKSVEKELEASRKEP-----E-A
>WP_131160034.1 reverse gyrase [Aeropyrum pernix]
------------------------------------------------------------------MGGVAVMPGG--------------------------------------------------------------------------------------VNAVYMGLCYNCGGNIDE-DRLENGLPCARC-LPS-PPRRVTPL-------------------------T----VYKALKKAGTL-------G----AYS-WEY--LSIREVERFESYFAAKS-GSRLWSAQRSWAKRLVKGDSFAIIAPTGVGKSTLLTVYAAYV-AA-V-------KG-G----RVLYLVPTENLVRQV---YAKLD-Q-----VEP-------G-I--------------------ATAYY-SRM--PAKARE-SSIEKIAS-GGA-R------LIVATTGFLSRRFDL-L-HP--RY----KFDLAIVDDVDSLLRN-SRNVERILLLTGFSE--ETVEAA-------HSLVKARL---KLYR-ALH-SGAS-----------ESI-VSR----LEQE-------I-----------AQLEARLRLSLSE----AS-PG-QL--VIASAT--GRPRGV-KHLLFKELLGFEVGGGSD-YLRNIVDAYV----VDSDP-------------------VGRAA------------EIASALG-D---GVIVFVSQRLGKDV-------ARAIAGRLEGM-GVSTALALTGA------RRPVEAFARGEAQVLIGMASRYGVIVRGLDLPERSKYAVFLGAPSAKTHLLE-----AL----YSPRRMLAFLSIAQ-----EKG------VE--WAGEAFRRLS-RLL--EKVI-----DTSIVS---------LVAR-GKL-----EAQ-GPAGEAAGIISE-TAPRLVDWLVAEARLQG--GLLRVG-G-L---VV--DA------RGPI--PYL-VVPDAPTYIQASGRVSRLYRGVMTRGLSIVVD--EA--PEYVEALGERLK--WTTSS-R-L------R-----------------PL------------SE------V-------DMERLRREIEESRR---------G
>PMP92034.1 reverse gyrase [Hydrogenobaculum sp.]
--------------------------------------------------------------------------MIE---------------------------------------------------------------------------------------AIFKNLCPNCGGDISS-YRLAKGLPCEKC-LKE-E------------------------------SEN----VC------DAL-------K--EGFLK-EHC--DIEKELSLWEEYFYKYT-NLKPWALQKTWAKRVFLKESFSLIAPTGIGKSSFGISLAAFL-S--T-------KN-K----KSYLLLPTKLLLKQT---FDRLL---------S-------F-GV---KEE------------DILIFGLDA--------K-KDKSLLKA-KNY-K------ILITTNMFLYKNEEL-I-P---RD-----FDFIFVDDIDSFLKT-AKNIDKLLHIMGFEK--DIINKT-------FELLKLK--------------------SS------FRK-NE-------EK-------L-----------KALSQEIADYLS--TNRPK--T-VL--VLASAT--SKPKSK-RVLAFKELLGFELSTPTY-YLRNITDAFD----EP---------------PNYKLN-YQTLV------------KYINTFG-K---GGLVFLSAEKGKDA-------IKEIIETLNKN-HIRAVSYEDI--K----EEDIKAYENGDIDVLVGIASYRNPLARGIDLPHVIRYAIFYGVPKIEIPL-------SL-E--TNINHIVMALLSIKNI-F-IN----TE-HYQTI-SELIEKLN-KYR---------------------------YVK-EE--------------------NE-VLKNLKQKAKEFLSQKDIIEKIENS-KDI---TLK-KQ-------NDK--YYI-LIPDVTGYIQASGRTSRLYAGGISKGLSVVLV--DD--KASFESLKKKLL--WLG-D-IKF------E-----------------NI------------KD------I-------DIKSILKAIDQDRENLRAF-MK-K
>WP_013130048.1 reverse gyrase [Thermosphaera aggregans]
-----------------------------------------------------------------------MSNLL-------------------------------------------------------------------------------------NPYGFYRHACPNCGGEISD-HRLFYKAPCEKC-LSE-GDFK-KTLK-RIRS--------EGLRDYKSIIEA----YY----KDLKN------PE----GLR-QLL--DEEVALEDFEEFFERATRGNKLWSAQRTWARRVLKKKSFSIIAPTGTGKTVFSLVISLYT-VA-K-----SQRG-DRR--RVYLVFPTLPLLLQA---ESKVK-HF----ATN-------A-GL---KIC-EDRAE-E-SCIRILVAH-GRS--DKKSKE-ELMEQVRN-GDF-D------ILLSTSAFFHRNFEL-L-KN--K-----DFALIVMDDVDAVLKS-GKAIRKLLNLVNVTD--DAINDG-------LNLIKLRQ---RIV----------------FSSG-EEK-EK-----LSAE-------I-----------EELEKKIARVKSEIKT-------TL--VVNSAT--GRPRGI-YPKLFKVFLDFEAGSKPE-AIRNIVDAY-----IEAD-----------------DP-ENALL------------EIASKLK-D---GFLVFVPVDRGVEY-------ADKIAELLKAH-GLKSESFHAK--KK---IDVLNDFARGELNCLVGVATYYGVMVRGIDLPERVKYVIFLGVPRHKFST-------AL-EE-ISPTDLLRIISVLRDI-A-PEE------SKREL-ESLVGRLS-NRL--KRISQG---ALFKLR-E--------DFA-KRL-----KGE-HV---EETVLIK-ELLRAYELARELLRDEEIWRKLSNL-GDV---GLL-WE-------NGR--QYL-LIPDVATYIQASGRCSRLYPGGITKGLSVIIV--DD--KRLLNGLNKRLR--WIFEG-VSI------A-----------------NL------------RE------L-------ELEKLITEIEQERVIVGKI-LR-N
>RLG60135.1 reverse gyrase, partial [Candidatus Geothermarchaeota archaeon]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WGKSYILVPTTPLVKQV---YQKIC-EY----ADK-------I-GI---NVN-------------VIRFH-SKM--RVSEKR-EFYNKLIN-GDF-D------ILVSTNKFLSTRFDD-I-KN--N-----IFKFIQVDDVDAILRS-SRNIERILRLLGFDD--DTIKYS-------MEEILLKR---RLVRI-----------RD------PTE-REE----IIQR-------I-----------QEINKFLSGKRG------S-KN-IL--IVSSAT--GRPRGT-RVKLFRELLGFEIGLRSE-TLRNIYDVYQ----ITTD----------------RDA-KEILL------------ELIKKLG-N---GGLVYVPVDKGIEY-------AEEIADYLRSN-GVKADVFASG---R---YDVLDKFLNRELDVIVGVAIYYGVMVRGLDYPERIRYAIFLGTPRFRFSA-------RF-DD-PNPIQMSKTLTLLRDI-I--KE------DKGEI-DSMIRVLN-RIM--KTFTIA---QYKRIL-E--------VLK-GGR-----AAE--------TKLEF-RILDILEYIRDMLSRDWVREGLKKH-PDV---EIE-EK-------DGE--FYL-IIPDVMTYIQASGRTSRLYAGGITKGLSIVLE--DR--EKLIKTLIRRIE--WIFEE-IKW------Y-----------------RL------------DE------V-------NLEKIVEEIDEDREMVRKV-RT-G
>ESQ24364.1 reverse gyrase [uncultured Acidilobus sp. JCHS]
-------------------------------------------------------------------------MPR--------------------------------------------------------------------------------------IEAVFRRLCPNCHGEITA-GRLAKGLPCSTC-LPE-EPEQADPI-------------------------S----IGEALQKLGKY-------G----SYL-ELS--YLERDFRDFSGYFEDKH-GFAMSSAQRSWARRLLLLDSFSIVAPTGVGKTTLLMAYAAYR-AE-K-------DK-W----RVLYLVPTENLVAQT---ADRVS-KI----VGA-------G-S--------------------VAYYY-SSM--RAEDRQ-AMMERIKG-QDY-L------VLVITPGFMVRNFDV-L-RA--AA----PYNLAIVDDVDSLLRN-SKNIDRTLMLLGFSE--EAISTA-------FRLVQLRL---DLAG-ALKAGHR-------------ER-AEQ----LTKE-------I-----------ASLSLQLQLKQSE----AQ-QG-QL--VIASAT--GRPRGV-KHLVFRELLGFEVGGGTD-YLRNVIDSYL----ISNDA-------------------MASII------------ELAQGLG-R---GGLIFVSRAYGKSM-------VKVVAEALNKA-GVRAVHAISNP------RRAVEKLVSGEADVAVGVASRYGALVRGIDLPEVIRYALFLGVPAIRLDLRT-----AL----LSPRRLLRALMFAE-----EK-------------DKSFSDYR-KRL--EALLRSYTVDSRIMA---------AVIR-GQL-----EAR-GRLEELRKLVLE-ASEGVVNLLEGLLQSEG--QTIRIG-T-M---VI--RR------ESGS--LWL-YSPDAPSYIQASGRTSRLFHGSMTRGLSVIID--RI--PELVDALQDRLR--WLSQA-Q-F------V-----------------PF------------KS------L-------DLKSVEKELEASRKEP-----E-A
>RLA85239.1 reverse gyrase [Deltaproteobacteria bacterium]
--------------------------------------------------------------------------MVS---------------------------------------------------------------------------------------GVFKGLCPNCGGDIST-ERLEAGLPCELC-LP----------------------------------DP-----S------GPF-------R-REGELT-LLH--RLEERERAWVEHFERYM-GARPWGLQVAWAKRVLLGRSFALLAPTGVGKTSFGISMASFF-T--K-------ER-E----RTYIIVPTRLLVEQV---RERLI---------D-------F-GL---REE------------ELLAFG-ED----DRQKR-ERKERLQR-GDF-S------VLITTSMFLYKNYEI-I-P---RD-----FSFIFVDDVDSFLKT-AKNIDKALLLMGFSE--GDIERA-------MTLIRLK--------------------ER------PNK-SES----DWQR-------I-----------RELGESVRE-CA--QR-AK--G-VL--VVSSAT--SNPRSS-RVKLFRELLGFEVGTPIF-YLRNILDTYC----DM------------------EG----GID------------RWIRKLG-K---GGLVFLPSDWGKES-------VSEVVTDLRSS-GIRAVSYEEL--D----EEVLKDYEEGKIDVIVGIASYRNPLARGFDMPHVVRYAIFYGVPKIVISL-------KF-E--TNLSHLLWALTSIRPY-V-AK--RLPQ-DVGRL-DRWIGQLR-RYQ---------------------------YLT-EGY-----VSE-------RPALAE-RISSLREELSRYLTSPEVLKMLEES-EEI---TLR-KG-------EDG--YYM-VVSDATGYLQASGRTSRMYAGGISRGLSVVFV--DD--PRAFNHLQKKVR--WFSDD-IKF------T-----------------FI------------NE------V-------DLQEVLRQIDLDRERMREI-RK-G
>PVU72936.1 reverse gyrase [Sulfolobales archaeon SCGC AB-777_J03]
----------------------------------------------------------------------------M------------------------------------TTELPP---------------------------------------------SVYLSSCPNCGGEISS-FRLAKGSVCSNC-LKS-EREFNSVFD-----------------------------LVSALKANGNL-------N----RLK-TFD--EIGRRFQRVAEFFRNSL-GFPPLGPQRSWVLRVLKGESFAIVAPPGLGKTTFGLIMAAYF-ASEE--------G-V----KSVIVFPTKTIVQQG---VERLQ-LI----AER-------T-KA---------------S-FNLVHYH-AGL--SESQKE-EALEALKS-GSF-D------VFLTTTRFMTTNVEL-L-REV-------KYRFLFVDDVDAALKA-SKSARAILEIGGFTE--DDIRDV-------KELLKQAR---T-------------------------D--ET----VYDK-------I-----------AELRKRRLS-----GK-------IV--VFSSAT--IT-RGS---PTVSSLMGFKPGGAVV-YLRNVIDAYLR---MPG---------------SEEEA-DELLL------------KLAKRLG-D---GILVFVPVDKGQKK-------GKQLAELLQDN-GIPSEFIASES------TRKIGAFANGELKALVGSAFHYGLLVRGLDIPWRVKYAIFYGIPKFKFRIG---------ET-PPPFLVSRILSVLATV-K----------QDKEL-ARLAGRIR-KRL--MAMSPS---GVAMLY-N--------EIK-EGK-----LE------------DE-TFKRAYEVVGETLKDAATLKVVAEK-GNI---II-----------EGD---SI-LAPDFLTYIQASGRTSRIYAGSLTTGLSILMV--DH--DALFQSLTWRLS--LVLEQ-VDW------K-----------------PF--------DLDSWT------IGG----SSADEIIGKIERERNEIIKA-RKES
>PMP89826.1 reverse gyrase [Caldisphaera sp.]
--------------------------------------------------------------------------MS--------------------------------------------------------------------------------------LNPIFRHLCPNCGREISS-NRLEKGLPCNTC-LEK-EVDENDPI-------------------------I----IGDILKKNNKL-------S----GYA-WLY--YLELSYKDFSKFFEDKT-SFNLSSAQKSWARRLLYPESFSIVAPTGVGKTTLLISYAAYR-AI-N-------SK-G----KILYLTPTENLVVQT---ARKFS-SF----LND-------G----------------------VAYYY-SSM--QKSDKE-FMTSRINE-GDY-K------ILIITPGYLIKKFDL-L-KR--YS----PYELIIVDDVDSLLRN-SKNIDRVLILLGFNE--GSVETA-------YKLVTKKI---DYTI-AL--SNKR-----------EEK-RKQ----LEEE-------I-----------ANLQVNLITSTNE----EAERG-QL--VIASAT--GRPKGI-KHLVFRELLGFEIGGGTD-YLRNVVDSYL----ITNNV-------------------IEETI------------NLIERLG-K---GGLIFISQSYGKKL-------AKPLVERLNNK-GIKAVQAITNS------RKAIEKLEKGQADIVIGLASRYGTIVRGIDLPEIIRYAIFIGTPSRKLELKT-----AM----LSPQRLLRIVMFLE-----EK-------------DKSFNSLR-KSL--ESFVSKYSEQSPIVV---------AVLK-GEM-----EAK-GILKTLKELIDS-SIDRVYNAVLNLIPNNG--DRLKIG-T-V---VI--SN------ENGN--LYL-YSPDAPTYLQASGRTSRLYYSHMTKGLSVIID--NI--PELVEGIKDRLK--WISMS-N-F------T-----------------DF------------KD------L-------DLNNVIKEIEETRR-------I-E
>WP_048078698.1 reverse gyrase [Desulfurococcus mucosus]
-----------------------------------------------------------------------MPDLPGSPS------------------------------------LPD----------------------------------------GFKTHGVYRHACPNCGGPISD-YRLIFKAPCEKC-LRD-EEFR-GIVE-LAGK--------RGGIDRFQLLRL----Y-----AESSR------EG----ALR-ELV--KREEMLRDFEAFFEKAT-GFKMWSAQKTWARRVLKGLSFSIIAPTGMGKTVFSLVTALYI-TQ-RA----RREG-DPRGWRSYLVFPTTPLLLQA---ERKLR-AF----AEN-------L-GV---SICSNDNWD-NGDCIRILCIH-GHL--GKRDRE-TAMNRLKE-GSF-D------ILLTTSAFIHRNYEL-L-KG--K-----GFRLIVMDDVDAVLKS-GRAVRRLLGIIGVEE--EHIEKA-------LTLVKAKS---RLV----------------AASG-EER-AR-----LEEE-------I-----------RGLENEVSSVRSRINT-------ML--LVNSAT--GRPRGI-YPKLFKVFMGFEAGSKPE-AIRNIVDSYV----EPQG-----------------GI-EEELV------------KLVLTLR-D---GVLVFVPVDKGVEY-------AERIVELLREK-GLRAEAFHSK--TS---IELLDAFAKGDVNVLVGVATYYGVMVRGIDLPERVKYVVFAGVPRHRFSS-------ML-EA-LSPTDILRVLAVLRDI-A-EGE------KRNLI-ERLLGRIS-SRL--RRMSPG---AVLRLR-E--------ELA-RKI-----RGE-SV---EETPLLS-TLFEAYKVIAEEFSKEETWQRISGL-GDV---GIL-KE-------NDK--YYM-LIPDVATYIQASGRASRLYPGGITKGLSIVVV--DD--KRLLNGLVRRMG--WIFED-FTM------T-----------------PL------------SQ------V-------NLEELMKQIEEERRRVSEV-IK-G
>WP_013562403.1 reverse gyrase [Desulfurococcus mucosus]
-----------------------------------------------------------------------MPDLPGSPS------------------------------------LPD----------------------------------------GFKTHGVYRHACPNCGGPISD-YRLIFKAPCEKC-LRD-EEFR-GIVE-LAGK--------RGGIDRFQLLRL----Y-----AESSR------EG----ALR-ELV--KREEMLRDFEAFFEKAT-GFKMWSAQKTWARRVLKGLSFSIIAPTGMGKTVFSLVTALYI-TQ-RA----RREG-DPRGWRSYLVFPTTPLLLQA---ERKLR-AF----AEN-------L-GV---SICSNDNWD-NGDCIRILCIH-GHL--GKRDRE-TAMNRLKE-GSF-D------ILLTTSAFIHRNYEL-L-KG--K-----GFRLIVMDDVDAVLKS-GRAVRRLLGIIGVEE--EHIEKA-------LTLVKARS---RLV----------------AASG-EER-AR-----LEEE-------I-----------RGLENEVSSVRSRINT-------ML--LVNSAT--GRPRGM-YPKLFKVFMGFEAGSKPE-AIRNIVDSYV----EPQG-----------------GI-EEELV------------KLVLTLR-D---GVLVFVPVDKGVEY-------AERIVELLREK-GLRAEAFHSK--TS---IELLDAFAKGDVNVLVGVATYYGVMVRGIDLPERVKYVVFAGVPRHRFSS-------ML-EA-LSPTDILRVLAVLRDI-A-EGE------KRDLI-ERLLGRIS-SRL--RRMSPG---AVLRLR-E--------ELA-RKI-----RGE-SV---EETPLLS-TLFEAYKVIAEEFSKEETWQRISGL-GDV---GIL-KE-------NDK--YYM-LIPDVATYIQASGRASRLYPGGITKGLSIVVV--DD--KRLLNGLVRRMR--WIFED-FTM------T-----------------PL------------SQ------V-------NLEELMKQIEEERRRVSEV-IK-G
>KUO87644.1 reverse gyrase, partial [Thermoproteus sp. JCHS_4]
--------------------------------------------------------------------------MR----------------------------------------FH-------------------------------------------ALPALYLHSCPNCGGAVES-YRLAEGLPCSEC-LPR-ETA-------------------------GGDIKR----IIEDLRRRNAL-------R----ELA-PLA--DNLRRYEEIGGLFERVV-GFRMWGAQRLWARRLAAGKSFAVVAPTGSGKTTFLLVSALYM-AG-R--------G-K-----ALLVFPTSALAYQA---YRKLL-DY----SSR-------G-GL---ALR-------------IATYN-TML--KPQERE-EALRRIEA-GDF-D------ILVITSAFLPKYFDL-L-AR--H-----KFAFVATDDVDSVLRATSKNIERLLKLLGATD--EVLGKA-------FELIELGK---RRG---KALL-A----GD------EKE-AER----IEHE-------I-----------EKAREELRKMRE--EL--R-LG-VF--IASGAL--AKARRTARLLLFREILGFDVGGRAE-GLRNVYDLYV----KMSE-----------------DP-KAQVA------------ELVKRLG-A---GGIIYVLD---REF-------GKELTQHLQAL-DIKAEHFFRP---R---RKVLEAFEQGQLSVLVGLASSRSALVRGIDLPHVIRYVVFVGIPKFKFRV-------EL-DE-FSVPAFLSFLYNVRAV-L-PQD------LRFKA-DRLIARLR-RIAP---YSA----RLDKIL-R------------EGA-----S-N-SF----EEYILD-VARSAVEFAADLLSRGDVRKAIETS-TEI---KLT-YI-------GDQ--LYI-LLPDATTYIQGSGRTSRLYAGGLSRGLSVILV--DD--EKVLNALIREME--LRFDD-VRF------E-----------------EL------------SK------A-------DLDSILRGIDEDRENIRRI-LS-G
>WP_015232464.1 reverse gyrase [Caldisphaera lagunensis]
--------------------------------------------------------------------------MS--------------------------------------------------------------------------------------LNPIFRHLCPNCGKEITS-DRLEKGLPCKVC-LET-ELEDNDPI-------------------------L----IGEMLKKSGKL-------Y----GYS-WLY--YLENSFREFKEYFEKTT-GYILSSAQKSWARRLLYPESFSIVAPTGVGKSTLLMVYTAFR-AI-N------GSD-K----KIMYLTPTENLVAQT---YERLK-AF----LND-------G----------------------IAFYY-SSM--PKKLKE-EMTTKINN-GEF-K------ILIITPGYLMKNFNK-L-KE--YS----PFGLIVVDDVDSLLRN-SKNIDRVLVLLGYSQ--ESVEIA-------YELVNKKM---NYGI-AL--SNKK-----------EDK-IKQ----LEQE-------I-----------SDLQMKLLLSNNE----EM-KG-QL--IIASAT--GRPKGI-KHLIFRELLGFEIGGGTD-YLRNVIDTYK----ISNSV-------------------FKDTV------------ELVKKLG-N---GGIIFISQSYGKNA-------VKPLLEMLKEN-GINAIQAISNS------RRAIEKLQRNEVSVIVGLASRYGTIVRGIDLPEIIRYAIFIGTPARKLELKT-----AL----ISPQRLLRIVMFLE-----EK-------------DQSFSSLR-KSL--ESFLSKYGEQSPLVA---------AVLR-GEL-----EAK-GILKTMKEVINN-SIPKVYNAILNYVPNDG--NIIKIG-S-F---VI--RN------EKNA--LYL-YSSDGPTYLQASGRTSRLYYGHMTKGLSIIID--EM--PELVESMSEKLR--WISQA-N-F------V-----------------KF------------ED------I-------NLDEVIKELEESRK-------I-N
>HCO38606.1 reverse gyrase [Aquificaceae bacterium]
--------------------------------------------------------------------------MIE---------------------------------------------------------------------------------------SLFKKLCPNCGGDISA-ERLSLGLPCERC-MPK-V----------------------------E-RDY-----C------RHM-------L-REGELS-KVC--HMEEELKRWEAHFEKHL-RSKPWSLQESWAKRVFLGNSFGLLAPTGVGKTSFGVSMASYL-A--K-------KE-K----KSYIILPTKVLVDLT---VQKLK---------G-------F-GL---KEE------------DILYFS-DD---SAKQKE-IKKARLQE-GDF-K------VLVSTSMFLYKNQEI-I-P---KN-----FDFIFVDDVDSFLKT-AKNIDKLLLLLGFDM--EDIELA-------MRLIRLK--------------------EK------RNK-DEE----DWEG-------L-----------KELADKVKE-VS--KK-RR--G-VL--VVSSAT--SNPRSS-RIKLFRELLGFEVGTPTF-YLRNVVDLYE----DI------------------NH---KPLE------------EWIRLLG-K---GGLLFIPSDKKKEF-------VDEVVSYLQEK-GIRAVSYEKL--D----DEVLKNYEEGEIDILVGISSYRNPLARGIDLPHVIRYAIFYGVPKIVISL-------RF-E--NNLSHLLWALMSLRSL-V-AK--RLPQ-RLRDI-DRWLESLK-RYQ---------------------------YLS-EEF-----LRD-------KPELAQ-RIEGLKEEVGSFLTSQEVIDLLMSS-EEI---TLR-KT-------EEG--YQM-VVSDATGYLQASGRTSRMFAGGISKGLSLILV--DD--KRAFKHLIRKVK--WFNED-INF------K-----------------SL------------EE------V-------NLEELLKEVDKDRQKIRAF-LQ-G
>WP_051654233.1 reverse gyrase [Persephonella sp. KM09-Lau-8]
----------------------------------------------------------------------MESKVIP---------------------------------------------------------------------------------------LIYKNMCPNCGGDITS-ERLFKGLVCENC-LPD-E---------------------------VP-RED----LC------DFL-------G--YGKFL-DVC--QLWSKVRDFKEFFRQII-KNDLWSIQETWATRFFLNISYALLAPTGIGKTTFGLVLSKYL-KD-K-------EN-K----KAYLIFPTQMLVNQA---HERLV---------S-------F-GV---PEE------------DILAYT-SKFAKTKKKQE-EYKERIKN-NDF-K------ILLTTTMFLYKNIDI-I-P---KG----EYGLVFVDDVDSILKS-AKNIDKVLMLLGFTQ--EDIDYT-------LKFITFKQ---NL-------------FKK------GQP-TEE----DFEL-------F-----------QHWQAKIQK-IA--EK-RK--G-VL--IVSSAT--SNPRSK-RVNLFRELLGFEVGRPSL-TLRNIEDVYE----K------------------PEKV-WEKSI------------DVIKKLG-K---GGLAFLSSSETRET-------LEKYVEFLNQN-GISAVSYEEL--M-----DRLDEYKEGKIQVAVGFASYRNPLARGIDLPDVIRYAVFVGVPKLQFNI-------RF-E--EEFIHLYYFMLSLTPF-L-ARKKLLDPLEVKQL-YDYINYLK-IYT---------------------------FIP-PEK-----LEP-------EK--LN-KMRQIQQYVKKLIEKPEIFSAVQQS-PEI---TLR-KE-------GDT--FIL-TTADVTGYIQASGRTSRLYAGGLTKGLAYLLV--DD--DKAFYSLQKKVR--WFSED-IEF------K-----------------PV------------EE------V-------NLEEILKQIDEDREKVKKV-LS-G
>WP_051654705.1 reverse gyrase [Persephonella sp. IF05-L8]
----------------------------------------------------------------------MESKVIP---------------------------------------------------------------------------------------LIYKNMCPNCGGDITS-ERLFKGLVCENC-LPD-E---------------------------VP-RED----LC------DFL-------G--YGKFL-DVC--QLWSKVRDFKEFFRQII-KNDLWSIQETWATRFFLNISYALLAPTGIGKTTFGLVLSKYL-KD-K-------EN-K----KAYLIFPTQMLVNQA---HERLV---------S-------F-GV---PEE------------DILAYT-SKFAKTKKKQE-EYKERIKN-NDF-K------ILLTTTMFLYKNIDI-I-P---KG----EYALVFVDDVDSILKS-AKNIDKVLMLLGFTQ--EDIDYT-------LKFITFKQ---NL-------------FKK------GQP-TEE----DFEL-------F-----------QHWQAKIQK-IA--EK-RK--G-VL--IVSSAT--SNPRSK-RVNLFRELLGFEVGRPSL-TLRNIEDIYE----K------------------PEKV-WEKSI------------DVIKKLG-K---GGLAFLSSSETRET-------LEKYVEFLNQN-GISAVSYEEL--M-----DRLDEYKEGKIQVAVGFASYRNPLARGIDLPDVIRYAVFVGVPKLQFNI-------RF-E--EEFIHLYYFMLSLTPF-L-ARKKLLDPLEVKQL-YDYINYLK-IYA---------------------------FIP-PEK-----LEP-------EK--LN-KMRQIQQYVKKLIEKPEIFSAVQQS-PEI---TLR-KE-------GDT--FIL-TTADVTGYIQASGRTSRLYAGGLTKGLAYLLV--DD--DKAFYSLQKKVR--WFSED-IEF------K-----------------PV------------EE------V-------NLEEILKQIDEDREKVKKV-LS-G
>PMP60131.1 reverse gyrase [Caldisphaera sp.]
--------------------------------------------------------------------------MS--------------------------------------------------------------------------------------LDPIFRHLCPNCGKEITS-VRLEKGLPCNQC-LEV-EIENNDPI-------------------------S----IGEALRKRGKL-------Y----GYS-WLY--YLEKSYNEFKEYFEKTT-SYYLSSAQKSWARRLLYPESFSIVAPTGVGKTTLLMAYTAFR-AI-N------GLD-R----KILYLTPTENLVAQT---AERLK-GF----IND-------G----------------------IAFYY-SSM--PKNMKE-DMLLKIEK-GDY-K------VLIITPGYLTKKFNK-L-KE--FS----PFGLIVVDDVDSLLRN-SKNIDRVLILLGFTE--ESVETA-------YKLVTKKM---DFSI-AL--SNKK-----------EDK-IKQ----LEQE-------I-----------SDLQMSLLNSNNE----EI-KG-QL--IIASAT--GRPKGI-KHLIFRELLGFEIGGGTD-YLRNVFDTYI----ISKDM-------------------LNEAI------------QLVKKLG-K---GGIIFISQSYGKNV-------VKPLINMLKEN-GINAIQAITNS------RRAVEKLEKGDADIIIGLASRYGTVVRGIDLPEIIKYAIFIGTPARKLEFKT-----AM----ISPQRLLRIVMFLE-----EK-------------NQSYSSLR-KSL--ESFLSKYSEQSPIVA---------AVLR-GEM-----EAK-GILKVLKDLVSN-SIDKVYKEMINYIPNDG--DRIKIG-S-F---VI--RN------EKGQ--LYL-YSSDGPTYLQASGRTSRLYHGHMTKGLSIIID--EI--PELIESISEKLK--YISQA-N-F------I-----------------KF------------DE------L-------NLDEVKKEIEDSRK-------I-N
>WP_014630416.1 reverse gyrase [Thermus thermophilus]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------ARYAAYCPNCGGEVES-ERLAAGLACARC-QPD-----------PAKPPLP-------------------GALARFFAQEEAL-------A----DW----------------ARFFAAHV-GAPPWPLQRAWAARVVQGRSFAMLAPTGIGKTTFGLLTALWL-AR-E--------G-R----RSYLVFPTRLLVAQA---AERLR-A---------------L-GA------------------PFVAYT--------GKPK-EKEALLEG-----ERP----IGLFTVAFLYKNHAR-L-PR--------PVDFLFVDDVDSLLKS-ARNVDRVLELLGFAP--EDLEKG-------LSLIRLRR-------------------KN------PEE-AER----M----------A-----------EGLRKKA-----------R--G-VL--AVASAT--ARPRSP-RVHLFRELLGFEVGTPSF-ALRKV-----------------------------ADL-YEEAFGLSHEALWARGAEWARRLG-G---GGLLFLPGDLPKEA-------ALDLARFLRAR-GLK---AKAY--LE---PEALEAFRRGEADHLVGFASWRNPLARGLDLPGRVRYALFLGVPKLRFALGE--------D--LAPGELVRLGLALLPL-L----------EDPGL-KALVRSLA-R--R-PGLQEK---EVAPL-----------------------RQA------LLERLAD-PAFRAR---------------VAES-PEVGLTFLG-EK-------P-----VL-VFADVTGYLQASGRTSRLTPAGLTQGLALLLA--ED--RKAFTALTRRLG---YLLE-APP------R-----------------PV------------AE------V-------DLEALLKRVDEDRDRLARG-ER-G
>WP_015739396.1 reverse gyrase [Ammonifex degensii]
--------------------------------------------------------------------------MEL---------------------------------------------------------------------------------------FLLAHGCPNCSGSVTD-ERLAAGLPCPQC-LPQ-AG-------------------------NNLSLAA----VCCALRKENKI-------R----ELS-PFC--RAEEGLKEFELFFRQVT-GLNLSPLQRLWAKRFFLEEPFAIIAPPGVGKTTFGLTVSLYN-P-------------Q----KSLILVPTRLLVWQV---AEKLS-HF----AEK-------A-GS----KK------------KILSMT-GK--------A-KEKKELMQ-SEY-D------ILVATTQFFYRHWSE-I-A---SH----PITLVFIDDVDALLKS-SRQVDSLFYFLGYSP--EEVERA-------LR---------------------------------SPE-GEP------------------------------REAGKR--------PQ--R-LL--ILSSAT--LKPRTN-RVRLFQRLMGFSVQRAVS-TQRRVVDCYE----EVPD---------------FARA-LARAA------------ELVRQLG-P---GGLVLVSPEEGREG-------VKEATAYLQAQ-GIEAESYLEL--TP---EELVSRLAEGSLEVAVGLAHPTNPLVRGLDLPHVLKYVIFVGAPSHFFPL-------DL-S--PAPGALHGLGLALFPL-F-TPE------EQRQV-LRELRYLR-PYL---------------------------NLP-ADA-----VSR-------YPALEK-RVQAFASFLKEKLKDPSFWEKIRAA-EDL---NLR-EE-------EGK--LYL-VLGDATTYLQASGRVSRLTAAGLTRGLAITLC--TE--RRVLLSLKKRLR-ALTPAE-IEF------I-----------------PL------------QE------V-------DLAGVMRGIEEDRRRIK----A-G
>WP_024119624.1 reverse gyrase [Thermus thermophilus]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------ARYAAYCPNCGGEVES-ERLAAGLACARC-QPD-----------PAKPPLA-------------------GALARFFAQEEAL-------A----DW----------------ARFFAAHV-GAPPWPLQRAWAARVVQGRSFAMLAPTGIGKTTFGLLTALWL-AR-E--------G-R----RSYLVFPTRLLVAQA---AERLR-A---------------L-GA------------------PFVAYT--------GKPK-EKEALLEG-----ERP----IGLFTVAFLYKNHAR-L-PR--------PVDFLFVDDVDSLLKS-ARNVDRVLELLGFAP--EDLEKG-------LSLIRLRR-------------------KN------PEE-AER----M----------A-----------EGLRRKA-----------R--G-VL--AVASAT--ARPRSP-RVHLFRELLGFEVGTPSF-ALRKV-----------------------------ADL-YEEAFGLSQEALWARGAEWARRLG-G---GGLLFLPGDLPKEA-------ALDLARFLRAR-GLR---AKAY--LE---PEALEAFRRGEADHLVGFASWRNPLARGLDLPGRVRYALFLGVPKLRFALGE--------D--LAPGELVRLGLALLPL-L----------EDPGL-KALVRSLA-R--R-PGLQEK---EVAPL-----------------------RQA------LLERLAD-PAFRAR---------------VAES-PEVGLTFLG-EK-------P-----VL-VFADVTGYLQASGRTSRLTPAGLTQGLALLLA--ED--RKAFTALMRRLG---YLLE-APP------R-----------------PV------------AE------V-------DLEALLKRVDEDRDRLARG-ER-G
>WP_013932339.1 reverse gyrase [Pseudothermotoga thermarum]
--------------------------------------------------------------------------MPL---------------------------------------------------------------------------------------AIYKEFCPNCGGEIEA-ERLEKGLACSKC-IPD-EI--------------------------SE-TE-----LCEILARKSEL-------K----NYS-WVC--CLKSLERQFCDFFTKNL-GFEPWALQRLWAKRVLSGESFTLIAPTGVGKTTFGIAMANFL-P-------------G----KAYILLPTRLLVEQV---AERCK-TF---------------------KAK------------KVVAYT-GK--------T-SERKTIEA-GDY-E------ILVTTNMFLATNFEL-V-QD--QR-----FSFIFVDDVDSLLKS-GKNIDRVLKLLGFTD--EEISQA-------WQKVSGK-----LL-----------EEKE------EET-MEE----EEEN-------ILEESSQEDEFNEE--NVLQ------TK-GK--G-IL--VVSSAT--LKPKTQ-RVKLFKSLLGFNVTPVKL-TIRNVCDAVE----WVDG---------------PQQA-LYRLA------------DWIRFFG-K---GGLVFVNREMGKDG-------VTTVVDFLKQQ-GINVSSYEEL---------DLESMRNGLIDVAVGIATYNNALVRGVDLPEVIRYAIFIDSPKISFAIE------QF-D---NPRNFVPLLLALREV-V-EDK--------SKI-DLYLERLR-RYQ---------------------------VFK-FEK-----QL------------PK-PLLEIAEYLRKNLNDESIVEKLEKA-ETI---GLQ-RK-------EGK--LFI-TFGDAANYLQASGRTSRLYPGGISRGISLILV--WD--KKAFHSLVQRLR--LFYEE-VDF------L-----------------SA------------DQ------V-------NWEEELKNVDADRKKIR-------
>RLG76389.1 reverse gyrase [Thermoprotei archaeon]
----------------------------------------------------------------------------------------------------------------------------------------------------------------MVLTAIFKELCPNCGGPISS-ERLELGLPCEKC-LPH-VEDK-VLKM----------------YGELNR-----------------------------------IW--EIEREVKKIDELFVRAV-GSKMWGLQRLWTRRFLNKESFAMVAPTGSGKTTMQMILSLYA-AN-K--------G-K----RTLIMLPTSLLAHQV---HQKLL-EL----RSK-------L-GF--DGVL-------------VSAYH-SLL--TNKQKRLELENTV----DA-S------IIVTTPISL-MKRAE-LQRP---------INIAFIDDVDSFLRK-SKSVDIVLKMLNVTP--EEIALI-------EKAQKMES---EAR---KLARED------------PER-ARQ----LISE-------A-----------AKLKTSIRLKVK---------G-QV--IVSGAT--QTARRTKRVRILNALFGFTVGGKIE-VGRNIVDMYI----KPPK-----------------ELFEKTIV------------NVVKKLG-T---GGLVFVPMDKGAEY-------VKKITDTLKKN-GISAEAYLGT---R---RRLFEKFIAGDVDVLVGITSYRSPLTRGIDLPERVRYAVFTGVPKFRLRI-------SF-EE-FHPSRWLILLNEIRDA-I-YEK------YPYEF-DRVLGGLI-KV---RLATRD---TLEAVR-E--------ALK-TGR-----SLT-GF----PEFVRK-VAEDALNFLNKVLKDEEVKERLRRS-RTI---TFG-EK-------AGE--YFF-IIPDATAYIQASGRTSRLYVGGITKGVSVLVI--DE--IKAFNALIRNLK--WLLET-VEF------K-----------------HY------------DE------V-------DIDKLMKEVDEDRRKVRLA-LE-G
>RLI24729.1 reverse gyrase, partial [Candidatus Bathyarchaeota archaeon]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTGIGKTTFGVAAALFL-G-------------G----KAYIMLPTSILVSQV---EKLAR-------------------RL---GGE------------GILAYH-TSL--SEKQRK-EVKEKIRH-GEF-S------LLITTSMFLSKNFDL-L-KG--QT-----FSFIFVDDVDSMLKR-AKNVDKVLMLLGFRE--EEIEEA-------MKASSTSSF-QQP----------------------------------------------------------------------SR-RV--G-LL--VVSSAT--AKPKTR-RVRLFRRLLGFEVGMPLG-GLRNVEDVVV----FP-----------------RGSL-VEEAV------------RLVKRFG-R---GGLLFIPSDLGREK-------IGEYVSALREA-GIEAESYEEL--N----EKLIERFERGEVQVLVGISSAKNPLARGLDLPQSVRYAVFAGVPKNRIPL-------DF-DR-LTIPQCLAVIVAVKPF-L----------EAARA-NRYLWELR-RNL---------------------------TAD-PS--------K-------SKRAEA-LLAEVRSFLAEALSNPEVVERIQKA-PNV---WLE-RK-------AEG--FEI-VIADAAGYLQASGRTSRLYAGGVSKGASFLLV--DN--EKAFNDLRRRLS--WFLEE-IEF------K-----------------RF------------EE------V-------NLESLFEAVDRDRRKIGEL-KK-G
>RLF66342.1 reverse gyrase, partial [Thermoplasmata archaeon]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LILPTSVLVKQA---YERMT-KL----NEL-------D-GK---EVK-------------IVAFW-SGM--KNSK---EMKEKIFE-GEY-D------ILITTSQFLSQNFES-I-KS--Q-----KFDFIFVDDVDSFLKA-YRNVERSLILLGFTH--KEVEEA-------YKLIR-------------------------------------------------------------------ENKIGE-----KEFER-KG-QI--IISTAT--GKTKGR-AYLLYRIMLGFTIGSTTW-QLRNVINFYR----ITDNP-------------------LTDLK------------FLINKLG-R---GGLIFVPHDLGHEY-------ASEIEAFLKRE-GLRALQVTAE--NK---LKALDAFVKGDVDVLIGVAHYYGILVRGLDLPELIRYAIFLGSPRFKFNL----------RELNDVSSISTTSIRLYRH-V-SEE------EARAI-DLIISFLK-R------ASRN---EIDLIN-K--------ALR-GEA-----SPG------RLEKFYN-AFIKAREIVLTYLSDEEKRKEIEKE-GEL---IIR-RE-------NGV--LYV-YIPDTRTYIQASGRTSRTYVGGITRGISIILERPND--RPILEGLMRVFR--YYLEE--PW------E-----------------EL------------RE------D-------KLEDEIRKVNEDRDLVKLA-KE-G
>WP_115793324.1 reverse gyrase [Ammonifex thiophilus]
--------------------------------------------------------------------------MEL---------------------------------------------------------------------------------------FLLAHGCPNCGKSVTD-ERLAAGLPCPRC-LPR-AE-------------------------GNLPFAA----VCRTLREEKKM-------G----GLS-PFC--RAEEGLKEFELFFRQAT-GLSLSSLQRLWAKRFFLEEPFAIIAPPGVGKTTFGLIVSLYN-P-------------Q----KSLILVPTRLLVWQV---TEKLN-HF----AEK-------A-SS----EK------------KILSLT-GK--------A-KEKRELMQ-GEY-D------ILVATTQFFYRHWPE-I-A---SH----PITLVFIDDVDALLKS-SRQVDSLFYFLGYSP--EEVERA-------LR---------------------------------SPE-GEA------------------------------REVGKR--------PR--R-LL--ILSSAT--LKPRTN-RVRLFQRLMGFSVQRAVS-TQRRVVDCYE----EVPD---------------FAQA-LARAA------------ELVRQLG-P---GGLVLVSSEEGREG-------VKEATAYLQAQ-GIEAESYLEL--AP---EELVSRLAEGSLKVAVGLAHPTNPLVRGLDLPHVLKYVIFVGAPAHLFPL-------DL-S--PTPGALHGLALALFPL-F-TPE------EQRQV-LRELRYLR-PYL---------------------------TLP-AEA-----VSR-------YPALEK-RVQALASFLEEKLKDPSFWEKVKAA-EDL---NVK-EE-------EGK--FYL-VLGDATTYLQASGRVSRLTAAGLTRGLAITLC--TE--RRVLLSLKRRLR-ALTPAE-IEF------T-----------------PL------------QE------V-------DLAGVMQGIEEDRRRIK----A-G
>WP_097001025.1 reverse gyrase [Persephonella hydrogeniphila]
----------------------------------------------------------------------MERQVIP---------------------------------------------------------------------------------------IIYKNMCPNCGGDISS-ERLFKGLVCENC-LPE-E---------------------------VP-RDE----LC------DFL-------G--YGRFL-DVC--NLWKKVGDFKKFFREII-KNDLWSIQETWATRFFLNISYALLAPTGIGKTTFGLVLSKYL-KN-K-------EN-K----KSYLIFPTQMLVNQA---HERLV---------S-------F-GV---PEE------------DILAYT-SKFAKTKKKQE-ELKERIKN-NDF-K------ILLTTTMFLYKNIDI-I-P---KG----EYSLVFVDDVDSILKT-ARNIDKVLMLLGFSQ--EDIDYT-------LKFITFKQ---NL-------------FKK------GQP-TEE----DFEL-------Y-----------QHWQAKIQK-IA--EK-RK--G-VL--IVSSAT--SNPRSK-RVNLFRELLGFEVGRPSL-TLRNIEDVYE----K------------------PEDV-WEKSV------------DIIKKLG-K---GGLVFLSSSETRER-------LEEYVNFLNKK-GINAVSYEDL--M-----DRLDDYKKGKIQVAVGFASYRNPLARGIDLPDVIRYAVFVGVPKLQFNI-------RF-E--EEYIHLYYFMLSLTPF-L-ARKKLIDPAQIKQL-YEYINYLK-IYA---------------------------FIP-PEK-----LEP-------DK--LE-KMRKIQLYVKQLIEKPEIFTAVQQS-PEI---TLR-KE-------GDT--FIL-TTADVTGYVQASGRTSRLYAGGLTKGLAYLLV--DD--DKAFYSLQKKVK--WFSED-IIF------K-----------------PV------------ED------V-------DLEKIIKQIDEDREKVRKV-LS-G
>OYT62562.1 reverse gyrase, partial [Thermofilum sp. ex4484_15]
-------------------------------------------------------------------MVLEPR-RH----------------------------------------------------------------------------------------AFFKSMCPNCGGEISD-ERLLLKLPCEKC-LPL-G-EA-ELKE-LASK-----------YGSKEYRRL----IAKLLEKRGNL-------R----GYK-EVL--ELEEYLEEFEELFKKAL-NSKMWSAQRTWAKRLLKGKSFAILAPTGVGKTVFGLLASLFL-AT-K--------G-R----KSYIVLPTTLLLLQA---AEKIE-EF----KKR-------A-GI---DAK-------------VLLYH-GRL--NNNYKK-EFAEKLEK-GDY-D------ILITTSQFLARSFDK-L-KG--R-----VFDFVFVDDVDALLKS-SKNIDRVLMLLGFKE--TAIKDA-------LNLIYLKR---GIA---SRLARK--------MDI-----PED----WRRQ-------I-----------EELRSRISNYLK--DK--R--G-VL--IVSTAT--GRVRGD-RVKLFRELLGFEVGSRAE-FLRNVADIYY----LPKGES----------------I-EEALV------------KIIKAMG-K---GGLIFVPTDKGVSY-------AEKLLSYLRSK-GLKVGLVTSE---D---KSALNEFIKGDLDLLIGVAIYYGLLVRGIDLPEIIRYAVFVGVPRFKFSL-------RL-EE-PHPVRMLQLLTTLRDA-L-SGE------LGDRC-ERYIALLR-RNI--FSLDRT---KFSKLM-E--------ALK-EGI-----EVS-GL----LSRLKK-LVLEVRSFLEDLLSREDVRERIKAL-EYI---SMV-EE-------GGQ--MYV-LVPDVMTYLQASGRTSRMYAGGISRGASIVIV--DD--LKLQRGLMRQSK--WYNED-VEW------R-----------------EW------------RE------I-------DLRELIKEIDRDRERIRKI-LK-G
>WP_079653426.1 reverse gyrase [Thermocrinis minervae]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------SYFLRLCPNCGGDISS-ERLYAGLPCEKC-MPE-I----------------------------R-QDV-----C------SYE-------D-LKGFME-KIC--KMEEELSEWEAFFQKRI-GSKPWSLQLAWAKRVLLGRSFALLAPTGVGKTSFGTSMAVFL-A--K-------KG-K----RSYIIVPTKLLLKQI---HNKLL---------S-------L-GL---EEE------------ELLYFG-DE---TEKEKE-KKRQLLQE-GRF-K------VLLTTSMFLYRNYQA-I-P---RG-----FSFVFVDDVDSFLKT-AKNIDKALYLLGFDE--EDIQKA-------LELIKEK--------------------SS------HNR--------DYEK-------I-----------KSLSEEVKK-LS--LK-AK--G-VL--VVSSAT--SNPRSN-RVKLFRELLGFEVGTPTF-YLRNVVDAYV----HE------------------RPT-IETLV------------NWIRKLG-K---GGLVFVSSDMGKEQ-------VEKLKEALSHH-GINSLTYEEL--T----EENLKLYEEGKVEVLIGIASYRNPLARGFDMPHVVRYAIFYGVPKMSISL-------KL-E--ENLSHLLWALTSIRSL-I-VK--QLPH-YGPTL-ERWIERLR-RYQ---------------------------YLS-EEF-----LEE-------KQDLKE-KVDNLKLEISKFLNSEDVIAILESS-NEV---TLR-RS-------EEG--YYL-VVSDVTGYLQASGRTSRMYAGGISKGLSLVLV--DD--VRALNHLQKRVR--WFNED-IKL------T-----------------PI------------EE------I-------DIGKIVEEIDRDREKIKNI-LA-G
>WP_014511171.1 reverse gyrase [Thermus thermophilus]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------ARYAAYCPNCGGEVES-ERLAAGLACARC-QPD-----------PAKPPLP-------------------GALARFFAQEEAL-------A----DW----------------ARFFAAHV-GAPPWPLQRAWAARVVQGRSFAMLAPTGIGKTTFGLLTAGWL-AR-E--------G-R----RSYLVFPTRLLVAQA---AERLR-A---------------L-GA------------------PFVAYT--------GKPK-EKEALLEG-----ERP----IGLFTVAFLYKNHAR-L-PR--------PVDFLFVDDVDSLLKS-ARNVDRVLELLGFAP--EDLEKG-------LSLIRLRR-------------------KN------PEE-AER----M----------A-----------EGLRRKA-----------R--G-VL--AVASAT--ARPRSP-RVHLFRELLGFEVGTPSF-ALRKV-----------------------------ADL-YEEAFGLSQEALWARGAEWARRLG-G---GGLFFLPGDLPKEA-------ALDLARFLRAR-GLK---AKAY--LE---PEALEAFRRGEADHLVGFASWRNPLARGLDLPGRVRYALFLGVPKLRFALGE--------D--LAPGELVRLGLALLPL-L----------EDPRL-KALVRSLA-R--R-PGLQEK---EVAPL-----------------------REA------LLERLAD-PAFRAR---------------VAES-PEVGLTFLG-EK-------P-----VL-VFADVTGYLQASGRTSRLTPAGLTQGLALLLA--ED--RKAFAALVRRLG---YLLE-APP------L-----------------PV------------AE------A-------DLEALLKRVDEDRERLARG-ER-G
>GBD04351.1 Reverse gyrase [bacterium HR19]
--------------MGSA----------ETKRYKVVDLDDQSD-----------------------KNYLKYRVMAY---------------------------------------------------------------------------------DQNFVPAYYISMCPNCGGDITS-DRLSLGFPCDKC-VPE-IPKGATFED-----------------------------ILRILENTGKL-------K----NFK-RIY--DIEKESERFAEFFKKIV-GFPPWSLQLAWAKRVLSSQSFMALAPTGVGKTTFGMVMSLFI------------SG------KSYIIMPTKLLSKLL---VKRLI-ES----ADK-------M-GV---NKK-------------ILFVD-SSKP--------SSKVRVVE-DDY-D------ILITTSMFLARNQEL-V-SR--K-----KFDFIFIDDVDSYLKQ-PKNVERVLKLMGLSD--EDMQEL-------KNLMNQKF---FLA---------------------RDR-EKT----LADK-------I------KDF--QKISEKVAEIRR------KISG-VL--VVSSAT--AKARAS-TIRYFREIFGFEISPYTT-TLRNIEDTVLYSDYDIKQGEEI--------EKVKINV-FEKVA------------DAIRKCG-K---GCFVFVSSEYGKQS-------VSELKNFLVTK-GINSITYEEFN------EKNQERFRAGEIDVVIGISSLRNPLCRGIDMPDAVRYAVFAGIPRFVFSMG------EI-DE---PAKLIGVLFSLRNI-L---------GNGKKI-YSFIETMK-KYA---------------------------GMRAEDI-------------EKYPAIKN-KIDSIKEFINERLKDPEFIQKIRDS-EDV---PIRVES-------DGR--FRI-VVADSSAYIQASGRTSRLYIGGLSKGLSVLIV--DD--RKSFFQLKKRLK-LDLLEN-LNF------K-----------------DF------------SS------V-------DISAVIQEIDKDRENIKNI-IK-G
>RUM49081.1 reverse gyrase [Hydrogenothermus sp.]
---------------------------------------------------------------------------MA---------------------------------------------------------------------------------------FISKGFSI-CGRNIGA-ERLYKGLLCKEC-LPE-E---------------------------IE-HSE----VC------NIV-------E--YGEYK-KVC--DTNKEVENFKQFFKEII-KNDLWSIQETWAKRFFLGVSHALLAPTGVGKTTFGLTLARYL-IE-K-------KK-Q----KVYLIFPTQILVNQA---YDRLI---------N-------Y-GV---KEE------------NILAYS-PKFAKSKKKQE-ELKNKISS-GNF-D------ILLTTVMFLYKNIDI-I-P---KG----IFSLIFIDDVDSILKS-AKNIDKVLMLLGFSQ--ENIEKT-------LEFIKFKA---KL-------------FRS------NSL-SEK----QLEE-------F-----------NKFQEEILK-IS--QK-RK--G-TL--IVSSAT--SNPRSR-RVLLFRELLGFEVGRPSL-TFRNIVDTYD----K------------------PENL-WKKSI------------EEIKKLG-N---GGLVFLSSSETKEK-------LEEYLQFLKQN-GINALHYEEF--L-----DKVEDYKSGKYPVAVGFASYRNPLARGVDLPDTIRYALFVGVPKLEFNI-------SI-E--EKFSHLYYLLLMVVPF-L-FRKKLIDQNTQLKL-YRYINFLK-IYG---------------------------FME-LER-----LPQ-------DK--QN-KLLEIKSFVLQLLNDKQIYEAIKNS-PEI---TLK-EE-------NGN--FTL-TTADITGYIQASGRTSRLYAGGLTKGLSYVLV--DD--EKAFYSLQKKVK--WFNED-IEF------I-----------------PV------------SE------I-------NLEEILKEIDKDREKVKKI-LK-G
>3P4Y_A Chain A, reverse gyrase helicase domain [Thermotoga maritima]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AA--EFWNEYEDFRSFFKKKF-GKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWL-AR-K--------G-K----KSALVFPTVTLVKQT---LERLQ-KL----ADEK--------------VK-------------IFGFY-SSM--KKEEKE-KFEKSFEE-DDY-H------ILVFSTQFVSKNREK-L-SQ--K-----RFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--EIIRKA-------FSTIKQGK--------------------------------------IYERP------------------KNLKP----------------G-IL--VVSSAT--AKPRGI-RPLLFRDLLNFTVGRLVS-VARNITHVRI----SSRS--------------------KEKLV------------ELLEIFR-D---GILIFAQTEEEGKE-------LYEY---LKRF-KFNVGETWSE---F---EKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDVYTYIQASGRSSRILNGVLVKGVSVIFE--ED--EEIFESLKTRLL--LIAEE--EI------I-----------------EE------------AE------A-------NWKELVHEVEESRRRSE------R
>3P4X_A Chain A, reverse gyrase helicase-like domain [Thermotoga maritima]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFWNEYEDFRSFFKKKF-GKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWL-AR-K--------G-K----KSALVFPTVTLVKQT---LERLQ-KL----ADEK--------------VK-------------IFGFY-SSM--KKEEKE-KFEKSFEE-DDY-H------ILVFSTQFVSKNREK-L-SQ--K-----RFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--EIIRKA-------FSTIKQGK--------------------------------------IYERP------------------KNLKP----------------G-IL--VVSSAT--AKPRGI-RPLLFRDLLNFTVGRLVS-VARNITHVRI----SSRS--------------------KEKLV------------ELLEIFR-D---GILIFAQTEEEGKE-------LYEY---LKRF-KFNVGETWSE---F---EKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDVYTYIQASGRSSRILNGVLVKGVSVIFE--ED--EEIFESLKTRLL--LIAEE--EI------I-----------------EE------------AE------A-------NWKELVHEVEESRRRSE------R
>3OIY_A Chain A, reverse gyrase helicase domain [Thermotoga maritima]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A--EFWNEYEDFRSFFKKKF-GKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWL-AR-K--------G-K----KSALVFPTVTLVKQT---LERLQ-KL----ADEK--------------VK-------------IFGFY-SSM--KKEEKE-KFEKSFEE-DDY-H------ILVFSTQFVSKNREK-L-SQ--K-----RFDFVFVDDVDAVLKA-SRNIDTLLMMVGIPE--EIIRKA-------FSTIKQGK--------------------------------------IYERP------------------KNLKP----------------G-IL--VVSSAT--AKPRGI-RPLLFRDLLNFTVGRLVS-VARNITHVRI----SSRS--------------------KEKLV------------ELLEIFR-D---GILIFAQTEEEGKE-------LYEY---LKRF-KFNVGETWSE---F---EKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDVYTYIQASGRSSRILNGVLVKGVSVIFE--ED--EEIFESLKTRLL--LIAEE--EI------I-----------------EE------------AE------A-------NWKELVHEVEESRRRSE------R
>RLI35078.1 reverse gyrase [Candidatus Bathyarchaeota archaeon]
---------------------------------------------------------------------MEVMELR----------------------------------------------------------------------------------------GIYRGLCINCGGRISD-DLLLETGLCRSC-L-----GG---------------------DVKVRGWGS----LIRRLSKEGKL-------K----SAL-DVY--SFLKELREFSSFFKKAL-GYRMWALQESWARRIFLGRSFSIVAPTGVGKTMLGVVMALYL-SL-K--------G-K----RSYIVVPTGILVEQV---TDRLM-DL----SRR-------L-DL---NMR-------------IAHYH-GSL--SQSAKR-EELSRIES-SEF-D------ILVTTDRFIVNHYEE-L-RS--L-----RFNFVFIDDVDSFLKS-PRNVDRILIILGFDE--ETVESA-------LKILNLRR---EAS---RISKMG-------------GD-PSE----VLES-------I-----------EELRARIRKYKA--EN--E-VG-LL--VVSGAT--LKAKRTRRIRLFEELLDFQLGFKPE-LLRNIRDFY-----LEKEKS----------------I-EEHVA------------EIMREYG-D---GCLIFVPTALGREY-------AERIGKFLSDK-GFRVHIYQGT---K---ENILKDFVERRCAALIGIASFRSPLARGIDLPERVRYVIFAGVPRMEIPL-------SW-DE-CNPTKLLALIRNIRGF-L-NED------ERGRA-DEVILRLR-RIVP---LSSD---VRARVE-S--------AIR-NQT-----ELE-GF----DEFVRR-IILDARSFLKEAIT-PEVIERIKGS-EEA---SIK-RE-------GDR--FHL-IVSDPVAYIQASGRASRMYAGGISRGASFLIV--DD--KKAFNSLRNRLR--FM-AD-VSW------S-----------------RF------------TP------R-------RVRRWLEKVDEDRRVIREL-ME-G
>WP_110380706.1 reverse gyrase [Acidianus sulfidivorans]
--------------------------------------------------------------------------MVT---------------------------------------------------------------------------------------SVYLKACPNCQGPLDE-TRALEGLPCTKC-LPG-DISPYKNL------------------PIEEKIRR----VYNILVTENKL-------N----AYW-NLY--YYLDSSLEIINYFKQIT-NNEPWSLQKLWLKRLIQGTSFSMSAPTGMGKTTTIIVFSTFL-AK-S--------G-K----SVLYIVPTKSLLQQI---CGKMK-NI----YND-------I-SC-------------------------GEV------------------DEK-RK-----INIVTTTYINRNFDK-I-KNY-------RPNFIAVDDADSIVKS-GKTVDRLVTLMGIPG--DVYEKA-------IRLVKLKR---LLAI--------------------EEK-RDE----IEKK-------I-----------AEIERDISKFYGT-------AS-QL--VVASAT--LRPKGI-KQKALRYITGFDVTTAQI-YARNIIDAYT----------------------------EKSLE------------EIITLLG-K---GGLILVSREYGKQK-------IKEIAEYLESK-GIKVAIAISG-------RKFLDKFSSGEVDIIIGSASYYGVAVRGIDEPKKLKYVVFYGVPKSRIRVNE-----AL----YNPF----TLLRVSKL-I----------------NVDID--ENKILS---LGTQ---ESQMIK---------LAFI-KSQ-----HLT-G----KLEETRK-YLEDKIKEVKEKLSKI-NENIIGDT---F---LIR-KI-------GKE--TYI-EFPDVITYLQGSGRSSRLLNDGLTLGLSITLV--DD--KKIYEMLTKRLK--YTIHN-FNP------V-----------------DF------------SS------I-------NINEVMKEIERTREE---------
>RMH03167.1 reverse gyrase [Aquificae bacterium]
--------------------------------------------------------------------------MVE---------------------------------------------------------------------------------------SIFKGLCPNCGGDISA-QRLELGLPCEKC-MPK-V----------------------------H-SSY-----C------GHM-------K-VKGALE-RLC--HMEEELRAWESLFEKSI-GSKPWSLQVSWAKRVFLGNSFALLAPTGVGKTSFGFSVALFF-A--R-------QG-K----KSYLIVPTRLLVEQT---VNRLL---------K-------L-GL---KEE------------EVLFFG-DD---SKKQKE-EKRQRLSE-GDF-K------VLVSTSMFLYKNHEA-I-P---KD-----FSFIFVDDVDSFLKT-AKNIDKVLYLLGFDE--QDIDLA-------MNLIRLK--------------------EK------R-----E----DWQR-------I-----------KELQEEVKR-RA--EK-RR--G-VL--VVSSAT--SSPRSS-RIKLFRELLGFEVGTPTF-YLRNIFDLYG----EL------------------S-----SLE------------EWVKRLG-K---GGLLFVPSDRGKDF-------VDELIKELEQK-GIRAVSYERI--D----QEVLKDYEEGKVDLLVGISSYRNPLARGFDMPHVVRYAIFYGVPKIVISL-------RF-E--KSLSHLLWALTSVRSI-V-AK--HMPE-KLPKL-DRWLEQLR-RYQ---------------------------YLT-EEF-----IED-------KPELKE-RLDNLRQSIGEFFSSPEFISLLETS-DEI---TLR-KT-------QEG--YQM-VVSDATGYLQASGRTSRLFAGGISTGLSLVLV--DD--PKAFKHLQKKVR--WFNDD-IEF------K-----------------RV------------ED------V-------DLQEVLKRVDEDRLKIRRL-MK-G
>ARM76586.1 reverse gyrase [Acidianus manzaensis]
--------------------------------------------------------------------------MVT---------------------------------------------------------------------------------------SVFLKACPNCLGPLEE-TRALEGLPCTKC-LPG-DITPYKNL------------------SIEEKIRT----IYNILVTENKL-------N----AYW-NLY--YYLDSSSEIIEYFKRIT-NNEPWSLQRLWLKRLTQGISFSMSAPTGMGKTTTIIVFSTFL-AN-A--------G-K----SVLYIVPTKSLLQQI---CEKMK-KI----YDN-------I-SC-------------------------GEI------------------NEQ-KK-----INIVTTTYINRSFEK-I-KNY-------RPNFIAVDDADSIVKS-GKTVDRLVTLMGIPS--EVYEKA-------IKLVKLKK---LLAI--------------------EEK-RDE----IEKK-------I-----------AEIERDISKFYGT-------AS-QL--VVASAT--LRPKGI-KQKALRYITGFDVTTAQI-YARNIVDTYT----------------------------QKSIE------------EIISSLG-K---GGLILVSRDYGKQK-------IKELAEYLESK-GIKVGIAISG-------RKFLEKFSAGELDVIIGSASYYGVAVRGIDEPKKLKYVIFYGVPKSRIRINE-----AL----YNPF----TLLRVSKL-L----------------KIDID--ENKILS---LSSS---ESQMIK---------LAFI-KSQ-----QLT-G----KLEETRK-YLEEKIKEAKERLSKI-NENIISDT---F---LIR-KI-------GKE--TYI-EFPDAITYLQGSGRSSRLLNDGLTLGLAITIV--DD--KNIYDMLINRLK--YTIYN-FNP------V-----------------DF------------ST------L-------NLDEIKKEIERTRKE---------
>WP_011229132.1 reverse gyrase [Thermus thermophilus]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------ARYAAYCPNCGGEVES-ERLAAGLACARC-QPD-----------PAKPPLA-------------------GALARFFAQEEAL-------A----DW----------------ARFFAAHV-GAPPWPLQRAWAARVVQGRSFAMLAPTGIGKTTFGLLTALWL-AR-E--------G-R----RSYLVFPTRLLVAQA---AERLR-A---------------L-GA------------------PFVAYT--------GKPK-EKEALLEG-----ERP----IGLFTVAFLYKNHAR-L-PR--------PVDFLFVDDVDSLLKS-ARNVDRVLELLGFTP--EDLEKG-------LSLIRLRR-------------------KN------PEE-AER----M----------A-----------EGLRRKA-----------R--G-VL--AVASAT--ARPRSP-RVHLFRELLGFEVGTPSF-ALRKV-----------------------------ADL-YEEAFGLSQEALWARGAEWARRLG-G---GGLLFLPGDLPKEA-------ALDLARFLRAQ-GLR---AKAY--LE---PEALEAFRRGEADHLVGFASWRNPLARGLDLPGRVRYALFLGVPKLRFALGE--------D--LAPGELVRLGLALLPL-L----------EDPGL-KALVRSLA-R--R-PGLQEK---EVAPL-----------------------RQA------LLERLAD-PAFRAR---------------VAES-PEVGLTFLG-EK-------P-----VL-VFADVTGYLQASGRTSRLTPAGLTQGLALLLA--ED--RKAFTALMRRLG---YLLE-APP------R-----------------PV------------AE------V-------DLEALLKRVDEDRDRLARG-ER-G
>WP_038057543.1 reverse gyrase [Thermodesulfobacterium hydrogeniphilum]
---------------------------------------------------------------------------ML---------------------------------------------------------------------------------------FYVANGCPNCHNIISD-ERLFKGLPCDKC-LDE-ES-----------------------KLSQFNINE----ICYILDSQKTL-------K----DLK-VYC--EVEKKVKIFKEIFNQIL-KTSPSSLQIGWAKRFFLGESFAIVAPTGTGKSTFGLISSILT-T-------------K----KALIIVPTKMLVKQV---EERLY-NY----LEK-------I-KEPYLKTK------------RILSYT-GT--------K-KEKELLEQ-GKF-N------IFICTSAFMHRNFDL-L-K---NI----DFSFIFVDDVDSFLKS-GKNVDNLFLLLGFSK--KEIELA-------LK---------------------------------RNK-NEK----DYEK-------L-----------LKIKEKHKN--------KL--K-QL--IVSSAT--LKPKTN-RVLLFQNLLGFEITRFVS-TLRKVIDSYI----SVDLNNLEKENSKDKKDLIFYKL-LEEAE------------KLIKYLK-E---GGLLFIEEAFGRSY-------VEIATNYLKDK-GYKVISYLEA--KE---KDLLNALKNKEVDVAIGLCHISNPLVRGVDLPEILRYVIFLGVPKHVFPLSKSKEGFSL-S--ISPQFLHNITLSLMPL-F-EDE------ERITA-LSYIAYLK-RYL---------------------------TLK-EEQ-----VSQ-------YEGLYK-KILSIKEFLESKLNNSEFIKKLEKS-DEV---FLERDE-------DGS--YNV-IVGNASSYLQASGRVSRLTTRGLLPGLSIILV--DN--FKALNSLKKRLR-FYLGDE-TEI------K-----------------EI------------NF------E-------EALKLDKKIKEERQKLI----K-E
>PMP66420.1 reverse gyrase [Thermodesulfobacterium geofontis]
---------------------------------------------------------------------------ML---------------------------------------------------------------------------------------FYIENGCPNCRGRISD-ERLSKGLPCENC-LPE-EN-----------------------VIS-SKISN----VCEILHAKNSL-------R----DLK-VFC--EVEKKVGYFKKIFNQIL-DISPSSLQIGWAKRFFLGESFAIVAPTGTGKTTFGLITSLLT-P-------------R----KALIIVPTKVLVKQT---EEKLN-YY----LGK-------I-KDKSLKNK------------IILTYT-GS--------E-KEKELLEK-GKF-D------IFVCTSAFMHRNFEL-L-K---II----DFSLIFVDDVDSFLKN-SKNVDNLFLLLGFSK--EEIELA-------LK---------------------------------RDK-EEK----DYEN-------L-----------LKIKEKHKK--------KT--K-QL--IISSAT--LKPKTN-RVLLFQNLLGFEITRFVS-TLRKVIDTYL----PVSLDD------KSDKEKVFLKL-LEIAE------------ILVKNLK-E---GGLIFVEENFGKSY-------VEIATDYLRNK-GFKVISYLEA--DE---EELLSALKNRKVDVAIGLCHLGNPLVRGIDIPEVLRYAVFLGVPKHVFPLSKDKEGFSL-S--ISPQFLHSILISIMPL-L-EEE------EKITA-LSHLNYLK-KYL---------------------------TLK-DDQ-----VMQ-------YEGLYK-KILSIKEFLEAKFNDPDFLENLKKS-EEV---FLEVDE-------EGN--YYV-IVGNASSYLQASGRVSRLTIRGLLPGLSVILV--DN--LKALNSLKKRLR-FYLGEE-QEF------K-----------------KV------------NL------E-------ELLELDKKIREERKQLT----E-G
>RLE71553.1 reverse gyrase, partial [Thermoprotei archaeon]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FIFVDDVDSLLKT-SKNIDRVLRLLGFTS--EIIDTA-------MQLLYTKR---MFA---SYLSRK--------RQP-----PPE----LIDE-------I-----------SSDERRIQKFIR--KN--K-IG-IL--VVSTAT--GRVRGI-RSKLFRELLGFEIGSRAG-FLRNIQDLYI----YTTSEK-------------K--I-FSLIA------------NIVKRLG-K---GGLIFVPIDRGIDY-------AKSLCTFLKNE-GVRAGVVYAG---R---KKALNEFIEGSLDVLIGVAIYYGLLVRGLDLPEKVRYALFTGVPRFVFSL-------EIPEA-ANPIRLLQIAFNIRDY-L-PPQ------YLEEL-DRITLRLK-TRI--SGLSQA---ALQRLF-I--------SIK-EGT-----ELM-GS----LAIVRD-EVFKLRDFLQKMLSDKSVIDNLKKS-RFL---SVR-EI-------DGK--LYI-YIPDTMTYLQASGRTSRMYAGGITKGLSIVIV--DD--EKLLSGLIRQTK--WYIDD-IDW------R-----------------NY------------MD------V-------NIDEILNEIDRDRENVKAI-LK-G
>PUA33193.1 reverse gyrase [Zestosphaera tikiterensis]
---------------------------------------------------------------------------------------------------------------------------------------MKSFY--------------------RSWRVLIKNMCPNCGGIIAE-ERLSKGLPCSSC-VPD-EALLEGG------------------------EVD----LPKVLSNLNKG-------F----KLL-DLF--LMEDELKRFEEFFTTVTKGKKLWSIQRSWVKRMLSGESFALIAPTGVGKSTLLQVYTLYN-AF-K--------G-K----AVLYLVPTRQLMTQV---AQSIK-SM----SNS-----------------------------NVIVTT-SD----------NFKE------YF-QMRDSGRVDILTHAFIYKNLSS-F-NG--LR-----YDVIVVDDFDALLKS-STIVNVLLNLLGISK--TALDLA-------TKVLQAKQ---EAVI-YKYLGNV-------------EK-MRE----LFVQ-------I-----------ENLELNLAKNLNY----VN-VG-QL--LIASAT--GRGRGS-RVRILRELLGFELGSITD-YMRNIVEAYQ----PLNY---------------------RELV------------ELLKKLT-G---GTLIFVSKDLGLSK-------AKELTNMLKAE-GFKVSLANS--------RRALDKMRNGEVDILVGVSTYYGILTRGIDEPLRIYNTVFMGIPKFELSLDA-----ML----LNPVSLAKLIGELP-----KHG------FK--P-STEDINVV-KAI--SRLNSG---SLKVLQ---------KGLK-GFI-----DLN-GYLKELSTLILL-TADRIRKFVEEELSKS---GKLVLS-H-L---VIK-RK------DKDI---VC-VIPDVMTYIQASGRSSRLLNGRMTLGLSVIFF--DD--EDLLKIFINRIK--NYINN-YTL------K-----------------PL------------NQ------I-------DLNYVKEQQRLSRS--LSS-YS-S
>WP_025306508.1 reverse gyrase [Thermocrinis ruber]
--------------------------------------------------------------------------MVK---------------------------------------------------------------------------------------AIFSKLCPNCGGDISV-ERLEKGLPCERC-MP--K----------------------------E-GDP-----C------KSL-------K--EGTLW-EVC--QVEKELLEWVEEFRKGV-SAEPWDLQRTWAKRVLMGHSFGLLAPTGVGKTSFGLSMVSFL-A--K-------KN-K----RSYVILPTKLLVEQT---VRKLK---------S-------F-GL---DEE------------HILYFG-DD---TEKEKR-EKKKRLEE-GDF-L------VLVSTSMFLYKNYES-L-P---KD-----FAFIFVDDVDSFLKT-AKNIDKALYLLNFSP--EDIELA-------LRLIRLK--------------------EK------LNK-SQE----DWEE-------I-----------KKLSEQVAR-VS--QK-RK--G-VL--VVSSAT--SNPRSS-RIKLFRELLGFEVGTPTF-YLRNVLDTYE----DI------------------NK---LPLE------------EWIRKLG-K---GGLIFVPSDRGKEY-------VDVLKEELSQK-GIACLTYEEL--S----EENLASYEKGEVDVLIGIASYRNPLARGFDMPHVVRYAIFYGVPKIVVSL-------RF-E--ENLSHLLWALSSIRAE-I-VK--KLPH-LSQKI-DNWLTALK-KYQ---------------------------YLS-EEF-----LQD-------KPQLRE-KIENLKREIEEFFNSEEVSRLLQTS-EDI---TLK-LE-------EDG--GKL-FVSDATGYLQASGRTSRMFAGGISKGLSLVLV--DD--RRVFKHLQKKVR--WFSDD-IEF------V-----------------EL------------GQ------I-------DLESVLAEIDRDRLLIRKF-LE-G
>PMP69636.1 reverse gyrase [Thermodesulfovibrio aggregans]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------SLFKGLCPNCGGEINS-QRLQKGIPCEKC-LPQ-Q----------------------------D-ADP-----C------KFI-------K--AGNYK-EIC--RINEDVQKWEKHFENHL-KLKPWSLQKTWAKRVFSGISFALLAPTGVGKTSFGISVASYL-A--K-------EN-K----KSYIIVPTKLLVEQV---CERLK---------D-------F-GL---KDE-------------ILAFN-EI---TAKLKE-----RLKK-ENF-K------VLVTTSMFLYKNQEI-L-P---RN-----FSFIFVDDVDSFLKT-AKNVDKVLHLLGFCQ--SDIAKA-------FELILLK--------------------AK------AKK-TDT----DWEK-------I-----------KEIQKELDN-VK--NY-KK--G-VL--VISSAT--TQPRSN-RVKLFRELLGFEVGTPTF-YLRNVVDAFT----E-----------------------EGSLV------------EWIKKLG-K---GGLVFLSSDKGREA-------IDEIMHELKKN-GIKAASYETL--N----NTTISRFEKGKIDVLVGIASYKNPLARGFDMPHVVRYALFYGVPKIVISL-------KF-E--SNLNHLLWAVSSIRSF-I-VK--KLPE-YTQKI-NSWISQLR-KYQ---------------------------HL---NF-----VEV-------KPSLKQ-KIENLTEEIGKFLSSKEVLDLLNSS-DEI---TLK-FT-------KEG--YFM-TVSDATGYLQASGRTSRMYAGGITKGLSLILV--DD--RATFKHLAKKVR--WFNDE-IKF------L-----------------SV------------SE------I-------DLDSTLKEIDEDRIKIKEF-LN-H
>RLG98218.1 reverse gyrase, partial [Candidatus Bathyarchaeota archaeon]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------VIYENLCTVCGKDLTH-EEIERK----VC-STR-N-------------------------------------------------------L--------HLSYSPYNVQDREFEELFRRVV-G-EPRDLQRFWMRRLVRQESFAAVAPTGIGKTTFGIVSALFF-AL-N--------G-K----KSYILVPTTLLVQQC---VENLA-GY----VEK-------A-GK---TVGLNEEGE-----ITVCFYH-SGM--KKDDKE-RFQELLER-GRF-D------VLVTTTQFLSKRFND-L-KG--R-----VFHFVFVDDVDAILKT-SRNIDRVLSLLGFEK----------------------------------------------------T-REG----WSGD------------------------------------AK--G-IL--MVSTAT--AK-RGR-STEVFRKLLNFDVGSSFF-TIRNVVDVAV----NTES--------------------LDEIK------------NVLRRMG-R---GCVIYARS---VEE-------AERYYELLKEE--FRIGLVVSR--R----KSDYELFERGELDHLIGTAYFYGTLVRGLDLPERIRYAVFIGVPLLRFRYE------EL---------TPKTVKTLALA-FRRNEE-----------------VR-KYLH----------LIPNLE-R---------------------------------HPR-ELEELKKVLRRVSETEKV--------EDL---VV------------RK--GEI-LFPDVRTYIQGSGRTSRLTVNGLTKGASFLFE--AD--EQILKAFMKRAG--YY--D-LSF------K-----------------SI------------EE------V-------DFQSLVRELEESR-------KA--
>AFH42708.1 reverse gyrase [Fervidicoccus fontis Kam940]
--------------------------------------------------------------------------MV--------------LG--------------------------------------------------------------------LMIKAVFQSLCPSCAGPISS-YRLSLGVPCNSC-LPS-SKLDNMEDI----------SKY----PLEKKIRL----ISKSLSDNPQ--------S----AYH-LMR--DTFEELESFEKLFREST-GKNIWSLQKTWAHRLLLGESFAITAPTGVGKTTLLLHYAAYQ-LK---------KG-E----KVYILVPTESLLNQT---EEKLK-EI----CYK-------M-GI---D-------------AEIVVYQ-SRA--SKKKRE-EVLKKIEE-GKF-G------VLITTTSFLSRRYDI-L-KK--LK-----FDLIVVDDADSLLKN-SVNIEKVLVLIGFDE--DDVKIA-------ERLIKCRN---ELFF-Y-LGTNN------------KEK-TEN----LKKG-------C-----------EELEVSLEEAKAK----KK-IG-QL--AVASAT--GRQAGS-KPKLFKELLGFEIGGIHD-YMRNIIDSFY----LYKEDKEL----------------IEKIK------------EIVNNLG-S---GGLIFVSKDLGVNR-------AKELVKELEDE-GIKTSLATAG-------KSVIKKLARGEVQVLVGVSSYYGVIVRGIDLPEVIKYAIFVGVPKNKMPLNS-----AL----FSPRRLLQALIYIS-----DKD------EN--I-KARFEDLQ-SKI--NKLNPG---EQFALR---------IALQ-KGTT---KQLS-GWLGEVADVILK-TISEVTIKLDSIIPREKG-AVLNLG-T-S---LIE-RG------EDGS--LYY-INPDPLTYIQASGRTSRFLNDKMTLGFCLIFE--KS--KEYLEVFKKKIG--NYVYS-FDP------K-----------------EL------------SS------I-------NLKEISERLILSRM-------G-K
>PMB78429.1 reverse gyrase [Fervidicoccus fontis]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------MIKAVFQSLCPSCAGPISS-YRLSLGVPCNSC-LPS-SKLDNMEDI----------SKY----PLEKKIRL----ISKALSDNPQ--------S----AYH-LMR--DTFEELESFEKLFREST-GKNIWSLQKTWAHRLLLGESFAITAPTGVGKTTLLLHYAAYQ-LK---------KG-E----KVYILVPTESLLNQT---EEKLK-EI----CYK-------M-GI---D-------------AEIVVYQ-SRA--SKKKRE-EVLKKIEE-GKF-G------VLITTTSFLSRRYDI-L-KK--LK-----FDLIVVDDADSLLKN-SVNIEKVLVLIGFDE--DDVKIA-------ERLIKCRN---ELFF-Y-LGTNN------------KEK-TEN----LKKE-------C-----------EELEVSLEEAKAK----KK-IG-QL--AVASAT--GRQAGS-KPKLFKELLGFEIGGIHD-YMRNIIDSFY----LYKEDKEL----------------IEKIK------------EIVNNLG-S---GGLIFVSKDLGVNR-------AKELVKELEDE-GIKTSLATAG-------KSVIKKLARGEVQVLVGVSSYYGVIVRGIDLPEVIKYAIFVGVPKNKMPLNS-----AL----FSPRRLLQALIYIS-----DKD------EN--I-KARFEDLQ-SKI--NKLNPG---EQFALR---------IALQ-KGTT---KQLS-GWLGEVADVILK-TISEVTIKLDSIIPREKG-AVLNLG-T-S---LIE-RG------EDGS--LYY-INPDPLTYIQASGRTSRFLNDKMTLGFCLIFE--KS--KEYLEVFKKKIG--NYVYS-FDP------K-----------------EL------------SS------I-------NLKEISERLILSRM-------G-K
>RLF55166.1 reverse gyrase, partial [Thermoplasmata archaeon]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------VIYENLCPVCNGELVD-EEILAG----RC-LKK-G-------------------------------------------------------I--------PISNSYQSEEEKEIERLFEKVI-G-KPREIQRFWIRRVSSGESFAAVAPTGIGKTAFGLVFSLYL-SL-K--------G-K----KSYVIVPTKLLVKQC---IENLE-RF----AGS-------I-GR---SLGKNDDGE-----IRVAFYH-GGM--RKEEKR-SFVRLLER-KGF-D------ILVTTTQFLSKNFDL-I-ES--V-----VFDFIFVDDVDAILKG-SRNVWRILHLLGFRK----------------------------------------------------V-GDR----WTGE------------------------------------SR--G-VL--MVSTAT--AK-KGK-ATRLFRELLNFDVGSSFF-TVRNIDDVFA----GRED--------------------IERIK------------EIMRMMG-K---GGLIYART---AED-------AERYQNLLSSE--FNIGIAISK--R----KNDYERFERGEVDFLIGTASYYGTLVRGLDLPYRIRYVIFIGLPSLKFSYD------KV---------TPSLLRIIALS-FKGNEK-----------------VR-EFLP----------ILPKID-R---------------------------------DPE-SFERLKEVIREVSRKEKS--------EDL---VV------------DG--EKI-IFPDVRTYIQGSGRASRLTERGLTKGASFIFE--SN--EELINAFSKRAS--YY--D-IEI------K-----------------NL------------EE------I-------DIDKLKREIDGSR--------I--
>RLG82433.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------MLYSGLCPNCGSLISE-DRLIAGLPCSKC-LPK-KYLPRGLG---------------SGLDVVR--------LRKVLESIGTV-------K----GLV-NRF--LIEDELSEFSSFFTRVT-GNELWSIQRAWARRILAGESFALIAPTGVGKTTLLQVYSIYK-AS-N--------G-Q----RILYVVPTRELMKQV---VSSLK-GL----TDL-------V-A------------------NNVLLLT-PD----------DIKK-----RGW-RLPDEGRVDVITHAFMHRNKEA-F-HK--LR-----YDIVIVDDFDALMKS-SSILGTILKVLGISE--ESISTA-------LKIVGTKS---ELMY-HKYMDNV-------------DR-VKE----LQEK-------L-----------YSLELELAKKLDY----SK-VG-QL--LISSAT--GRAKGV-RAKVLRELLGFEIGSIMD-YMRNIVEVVE----SLKS---------------------VDIC------------KLVRGLE-G---CTLIFVSKDYGLNY-------AKELVDMLKGC-GFSVAIANS--------RRALDLLRQGRVNILVGISTYYGILTRGIDEPLKIYNVVFYGIPKFEIPIDN-----IL----SNPLALYRLMLGLT-----SYG------YE--M-SGQEKQLF-NSL--KKLSPA---KLKLLA---------MGLR-ERI-----ELS-GPLEGLKEALERDVIPRVRSFIAKYLVAK---GKLVSG-G-Y---VLV-KK------NRRI---VA-LTPDVMTYIQASGRCSRLLMGKMTLGLAILLY--DD--EDLLNIFMGKVK--NYVTS-FSP------K-----------------KL------------EE------I-------DLDRIKRLQKESRNINIAS-LQ-G
>RLF13742.1 reverse gyrase, partial [Thermoprotei archaeon]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDE-EEAA-ELLK-KVEEGQ-------------DLKKL----VLEALEGKGRL-------K----HYA-EVA--KPQFKAEEFNNFFKKAL-GLPLWSAQRTWAKRVLTGRSFAIVAPTGVGKTVFGLAMAAYL-AS-K--------G-E----KCYVVSPTTLLIEQA---RRRME-EI----LEA-------S-GL--KQLK-------------VAYYS-TAL--HRAEKI-EEADRIKK-GDF-D------ILITTSSFLARNFEE-L-KR--R-----RFGFIFVDDVDAILKA-SKNIDRVLVLLGFKE--EDVEKA-------LELLKLRG---ELA---RALRRR--------EEL-A---VEE----LRGR-------Y-----------EQLSKEVARRLK--RR--K-PG-LL--VVSTAT--GRARGI-RVKLFRELLGFEVGSRAE-AIRNIQDIYL----KPRE-N----------------L-DEEVA------------ELAKKLG-P---GGLVFIPLDRGVES-------ADRIAKMLAKK-GVKAEVVYAK--GK---KERIAAFAKGEVDVLIGMASYYGLLVRGLDLPERVRYAIFAGVPKMRFSL-------EV-KE-AYPSRVLQLLLDVKDA-L-TGD------EQVTA-LRLIGRVR-RLL--WRLTPA---SFRELK-E--------ALE-KGV-----EPP-SW----LKQAYS-TVKEAADFLFQALSRSEVREKLRKS-THL---SFT-EE-------EGR--VTV-TVPDVPTYIQASGRTSRMYAGGVSKGVSIVVV--DD--EKVFTGLARQTR--WLADE-VRW------V-----------------SL------------EE------V-------DLEGLMKEVDDDRERVRRL-LS-G
>RLE93872.1 reverse gyrase, partial [Thermoprotei archaeon]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YSE-------L-----------NELKDKLEKILK--GK--L-KG-CL--VISTAT--GKPRGA-RVKLFRELLGFEIGARTE-ALRNVVDSYI----LPGSED----------------I-DDEVV------------KLIKTLG-K---GGLVFVPVSKGLEY-------AQALNEKLRQA-GIRSEVVHAK---K---KSALDRFVSGEVDVLVGVAVYYGLLVRGLDLPHIVKYAVFAGVPHFKFSL-------NL-EE-AGPFRLLQFAFNIRPA-L-EGY------EQSQL-DRLVGKIR-RVI--YDLDAA---SVQILT-E--------ALK-EGK-----ELE-GR----LEYVRK-NLVKLKHLLIQELSKKDVVKRLEEK-TML---VIR-TE-------EGQ--QYI-YVPDTMTYLQASGRTSRLYAGGLSKGLSVVVV--DD--EGLFNKLVRQSR--WYSDE-IEW------V-----------------NF------------ND------L-------DVEKLMKEINKEREFIAKL-IR-G
>WP_126449258.1 reverse gyrase [Sulfodiicoccus acidiphilus]
--------------------------------------------------------------------------------------------------------------------MVE---------------------------------------------AVYARSCPNCGGDIRA-SRLTLGSCCSRC-IEE-DVEFPSLNV-----------------------------LLATLSRSGKL-------K----FLR-EEE--MVLRELDSLSTYFRAMT-GSTLTGPQRSWALRFLRGESFSITAPPGMGKTTFGLSASIFN-AV-R--------G-A----KSVLVFPTKSLVSQA---EVKLR-DVT----------------------------------SKL------GL--SVKFVS-TVKKEPEG-EDF-H------ILLTTSKYAMLH-RE-L-ANH-------DFRMIFVDDVDAVTKS-RKSTYMLLELAGFSK--DELSSL-------RDASREGD---SL------------------------------------K-------V-----------REIRERVLN-----GK-------VV--ILSSAS--VT-RVT---PIISSALGLRPGGTAI-YSRNIVDTYME---FPS------------------DV-AVELK------------KVLRTLG-T---GGLVYVSVDKGMEL-------AKRIHEELSE--ELRVGLVNSTS------SKAVERFRGGELDYLVGVATHYGPLVRGLDMPSRVRYAIFVGVPKFKFVLG---------EK-MHPLAALRLLVTLASV-K----------RLTEL-YSLVGQMR-KKL--RTLSPS---ALAVVA-N--------AIR-EGK-----LE------------DK-VFARVYDVVQRSLEDKETLQRMMEA-GGF---VL-----------QDG---LL-LLPDYVTYLQASARTSRLLGGGLTTGLSVVLV--DD--WRLFSAFKNRLS--FVLDD-VIW------Y-----------------PL--------NLAEGK------VGD----KELGDLMSKIDEER-----------
>WP_013909051.1 reverse gyrase [Thermodesulfobacterium geofontis]
---------------------------------------------------------------------------ML---------------------------------------------------------------------------------------FYVAKGCPNCKGIISD-ERLTKELPCEKC-LPE-KE-----------------------KPSLSNFSD----ICKILYSQNSL-------K----DLK-PFC--EVEKKIELFKKVFKNLL-NTFPSSLQIGWAKRFFLGESFAIVAPTGTGKTTFGLISSLFT-P-------------K----KALIIVPTKVLVKQT---EEKLN-QY----LAK-------I-KEPLLKNK------------IILAYT-GS--------N-KEKELLEK-GKF-D------IFICTSAFLHRNFEL-L-K---NI----DFSLIFVDDVDSFLKN-SKNVDNLFLLLGFSK--KEIELA-------LK---------------------------------RDK-EEK----DYED-------L-----------LKIKEKHKK--------SI--K-QL--IISSAT--LKPKTN-RVLLFQNLLGFEITRFVS-TLRKVIDTYI----PVDLND------KKNKDEVFYQL-LKVAE------------NLIANLK-E---GGLIFVEESFGKSY-------VEVTTDYLRNK-GFKVISYLEA--DE---EELLNALKNKKVDVAIGLCHIGNPLVRGIDIPEVLRYALFLGVPKHIFPLSKSKEGFSL-S--ISPQFLQSILISLMPL-F-DEE------EKIIA-LSHINYLR-RYL---------------------------TLK-EEQ-----VMQ-------YEGLYK-KILNIKEFIEKKLNDPDFLENLKKS-EEV---FLEVDD-------EGN--YYV-IVGNASSYLQASGRVSRLTTRGLLPGLSIILV--DN--FKALNSLKKRLR-FYLGEE-VEL------K-----------------EV------------DL------E-------KVLILDKEIREERQKLT----K-E
>WP_013776211.1 reverse gyrase [Acidianus hospitalis]
--------------------------------------------------------------------------MVT---------------------------------------------------------------------------------------SVFLKACPNCGGPLED-YRALAGLPCSKC-LPG-DISPFKNL------------------SIDEKIRL----IYNILVHENKL-------K----GYW-NLY--YYHQLSQEIIDYFKKIT-GKEPWSLQKLWLRRLVEGSSFSMSAPTGMGKTTTIIVYSTYL-QN-S--------N-K----NVLYIVPTKSLMQQI---CEKME-KI----GDK-------T-SC-------------------------GKV------------------GS---G-----ISIVTVNYINRNFEE-I-KEY-------RPDFVAVDDADAIVKS-GKTVDRLVTLMGIPQ--EVYEDA-------IKLVKLKR---LLAI--------------------EEK-RDE----IETK-------I-----------AEIESRISKYYGT-------AS-QL--VVASAT--LRPKGI-KQKALKYITGFDVSTAQI-YARNIIDAFT----------------------------SSSVV------------DIVNKLG-S---GGLILVSKEYGKDK-------IKEVNESLKEL-GFKTAIALSG-------RKFLEKFSSGEIDIIIGSASYYGVAVRGIDEPKRLKYVIFYGVPKSRVRLSQ-----AI----YNPY----TLLKISKL-F----------------NVNID--DNLILS---LSPS---EAQLIK---------LAFL-KSQ-----KLT-G----KLGEIQK-ILEGKIDEVKSALKAV-SNEVISDT---F---LIR-KI-------GKE--FYI-EYPDAITYLQGSGRSSRLLNGGLTLGLAITII--DD--FKLYEMLKRKLQ--YMIYN-FNP------T-----------------NF------------DS------L-------DIGKVKNEIERSRND---------
>WP_011249425.1 reverse gyrase [Thermococcus kodakarensis]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AVYREMCPNCWGRISD-ERLVMRNPCEEC-L-----DE-PVHA----------------DSYFQLVSA----VRNALKLRGTL-------K----EWE-KIY--QLENQTREIEEFFKKAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWH-AL-K--------G-K----KSYIVVPTTPLVIQT---VRKIE-GI----MEN-------A-NA---DVR-------------LAYYH-GNL--RKKEKE-EMLERIKN-EDY-D------ILVTSAQWLARNYEEVL-KG--R-----HFDFIFVDDVDAFLKA-SKNIDRSLYLLGFTD--EIIQKA-------WEIIRLKK---QMS---RYLNGN-SEDRN-------EK-LNG----LNRE-------I-----------EKLQREIEKFKR--KN--K-IG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVVDSYL----KPTK-----------------DI-KEHVE------------ELLTRLG-K---GGLIFVPVDQGLGY-------AEELANYLSEK-GFKIELVSSK---N---KKALEKFENGEADYLIGSATYYGSLVRGIDLPHLIRYAVFTGVPKFRFSI-------DL-ER-PTIYRALGLLSEIMDF-L-SEE------DRRQA-EKLHARLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PIENEF----HNHVLG-VFRELVEFLRRVLRDEEVLRKLAED-PFI---SLV-KE-------EGK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKVFNGLVRQMR--WRFQE-FKM------V-----------------PF------------EE------L-------DLDEILRQIDEDREKVRLV-ME-G
>RJS74426.1 reverse gyrase, partial [Candidatus Bathyarchaeota archaeon]
--------------MGRN--------------------------------------------------PSKI--MK----------------------------------------------------------------------------------------AIFKGLCPNCGGDIDD-ERASMGLPCRMC-L---P-DE-------------------------------------YLKSPNPLAYVRNPSE----TYS-RLI--YESKQLEEFISFFEKAT-GSKPWAAQRVWARRIIAGRSFALIAPTGMGKTVFGSVFALFL-AY-K--------R-G---WRSYIVVPTALLAKQV---SERLL-SY----AER-------L-GL---DIK-------------IAYYH-SLL--TRKEAK-SRLEEIKN-RDF-Q------VLVTTLSFLNMKFEF-I-EG--E-----RFKFIFVDDVDSLLRS-SKSVDKILMLLGFKQ--EDLEKA-------FNIMDLRT---QLG---RLLRRR--------RY---SE-SSE----LYDK-------I-----------VKLMEELEE--N--RK--N-VG-VL--VVSGAS--IRARRTKRVRLFRELLGFEVASRID-IGRNVVDLYT----EAK--N----------------L-EEETY------------RLIKKLG-P---GGLVYIPMDLGAEY-------AESLKKYLVER-GINTEAYTRP---R---KRILEKFSQGVYDVLIGVASYRSPLVRGIDLPYTVRYALFVGVPKMLIDL-------DIKHR-FRISKAIILLANIREL-L-PER------DQLEA-LRLINELR-IAN--RIISRD---LREEIA-K--------SIA-EGK-----PLP-PI----PERAKI-AVEEALEFLSDILSRPDVLKALEES-PYI---GLE-KR-------GDV--FYL-IIPDPVAYVQASGRVSRMYAGGVSKGISIVLV--DN--DRAFNGLMRETR--WFMED-IVW------R-----------------RL------------SE------V-------DLDKVIEEVDKDRKAIKDL-LE-G
>RLG72632.1 reverse gyrase, partial [Thermoprotei archaeon]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILKS-SKNIDRVLMLLGFTE--NDIQTA-------FELIKLKR---RLA--QKTLSNQ-------ER---IKL-LKE----VN-K-------L-----------RKYVEYASR--K------V-KG-VL--IVSSAT--GRPRGL-RVRLFRELLGFEVGTRSE-HLRAIVDTYL----KPDK-----------------SI-EEEVA------------SIVKVLG-K---GGLIFVPIDKGIEY-------AEKLSSFLRSK-GIKAKVFVSK---E---IKALEEFIRGEVDVLVGVATYYGVMVRGLDLPEIVRYAIFAGIPRFKFST-------KL-DE-PHPLNIMRALVILREV-LEKEE------DKEKV-DRLIARMK-RFI--AIAPAA---VVSEIA-K--------KLK-ENI-----PPE--------TAAEK-MFYEALAIARSLLEDPEIKRKLKDL-KEI---TIV-EE-------NGK--MFI-LIPDIMTYIQASGRTSRMFVGGITKGLSVVIV--DD--ERLLYGLLRRTK--WFIED-IEW------F-----------------DF------------KT------I-------DLEKLLREIDEDRELVKAV-RA-G
>OYT49157.1 reverse gyrase [Desulfurococcales archaeon ex4484_42]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------MIIRNLCPNCDGPIHE-DRLRRGLPCHNC-IPN-EY-----------------------IKYVRTRSN----LRKIMQSLNKV-------K----GML-SLF--LLEDELKEFESFFKKIL-GKELWSIQRSWAKRMLSGESFALIAPTGVGKTTLLQVYALFK-AS-R--------N-H----KVLYIVPTTELLNQL---ATSLN-NL----KKN-------L---------------------DTAIIT-SQ----------EFKKSLLS-NSY-NTLNKGLIVITTHAFIHKNKEL-F-ND--KH-----FDLVIVDDFDALMKS-SSILNLILKLLGISD--NAIKLA-------FKIISLKQ---ELAF-YKVLGKD-------------DK-LKE----VQER-------L-----------YEAELELTKSINY----DN-IG-QL--LIATAT--GRARSS-RAKILRELLRFEIGSILD-YMRNLVEVVE----PLDS---------------------IDLT------------NLISKLI-G---GTLIFVSKDLGMRK-------AEEVEQELLKK-GIKAEIAKN--------RRSLDKLRRGEINVLIGISTYYGILTRGIDEPKRIYNVIFIGIPKFMIPLDN-----AL----NNPLRLVRLLQQLQ-----QYS------YT--L-NDEEKNLI-RVL--SKLSPS---KIKAIT---------VSIK-KGV-----ELN-PPLSDLVKLVLK-VENRVKRFIFDYVSRK---GKLVLE-D-S---III-KR------DNKC---YL-LIPDVMTYLQASGRCSRLLNRHMTLGLVILLY--DD--HDLLNIFMRRLK--YYVLK-YSP------L-----------------RL------------KD------I-------NLKEIQDLQVKSRNEEFSG-TE-A
>WP_127680636.1 reverse gyrase [Nautilia profundicola]
--------------------------------------------------------------------------MIN---------------------------------------------------------------------------------------MIYKKSCPRCGGDISS-YNLEAGVFCDKC-MQD-LQ-----------------------TDNIA-DIE----NC------DIM-------K----NYE-LFC--KARLEFKEFELFFKNKT-GNILNPIQRMWAKRFFLGSSFVLLAPTGIGKTTFGLLLSAFV-NK------------------SYIMFPTKLLVKQA---LNKYK---------E-------W-GI---NA---------------LAYT-GK--------K-EEKEKIKK-GEY-D------ILVTTTQFMYKNRAI-I-N---K-----KFNLIFVDDVDSILKS-GKKINDILLLLGFDE--KTLEKT-------LALIKEKK---Y-------------------------------------------------------------DEIKK-LN--KK-SI-YG-NL--IVSSAT--ANPKSK-RVLLFKYLLGFEISRPSF-NLRNIEDLYE----E-------------------ECS-WEKSA------------KWIKKLG-R---GGLVFLPGSETKEK-------LNDYIKYLQEH-DIKVYSYEEF--E-----EHLEEFKEGRC-CFAGFASYRNPLARGLDLPEHIRYTLFTGVPKMVFDL-------S--E--TNYRALYFIMIELLSV-L-AESGI-SDVDLEKI-KYALEYLK-RYV---------------------------FII---K-----PSG-------SA--EE-KIAKITEQLRGLIQKYD--SLIKNS-KEI---NFD-GE-------------KI-IIADVTGYIQASGRSSRFYKGHLTKGFSLVLI--DS--QKAFYSLQKKLK--WFGN--IEF------K-----------------NI------------KN------V-------NLKQLINEVDESRK----------
>RUM57176.1 reverse gyrase [Persephonella sp.]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------IIYKSMCPNCLGDISS-DRLEKGLPCENC-LPE-E---------------------------VP-VNE----VC------DFI-------G--YGQFR-NIC--DLWNKLKDFKKLFKELI-KNDLWSIQETWAIRYFLNTSYALLAPTGVGKTTFGLILSKFL-TE-K-------EN-K----KVYLIFPTQVLVNQA---YDRLI---------N-------F-NV---SSE------------RIVAYS-DRFAKSKKKQR-KLKERIKA-QDF-D------ILITTTMFLYRNVDI-I-P---KG----VYSLVFVDDVDSILKS-AKNIDKVLMLLGFSE--EDIEKT-------LKFISFKQ---KL-------------FSR------KNL-TEE----DLES-------Y-----------RKFQEEINN-IS--KK-RK--G-AL--IVSSAT--SNPRSK-RVSLFRELLGFEVGKPSL-TLRNIVDTYE----KV----------------EEEEL-WEISV------------DKINKLG-K---GGLVFLSSSETVER-------LNEYVDYLREK-GINAISYEDL--M-----DNLEKFKSGEIPVVVGFASYRNPIARGLDLPDVIRYALFVGVPKLQFNI-------RF-E--EEFIHLYYFLLTLTPF-L-IKKRLVDENKIKEL-YEYIRFLK-VYS---------------------------FIP-FEK-----LDK-------NK--QE-KLLRIKDFVKNLVEEENIYAQIKNS-PEI---TLK-KV-------NGS--FIL-ITADITGYIQASGRTSRLYAGGLTNGLAYLLV--DD--EKAFYSLQKKAK--WFSED-IQF------K-----------------PV------------EE------I-------DLERLLREIDEDREKVKKI-LA-G
>WP_014122201.1 intein-containing reverse gyrase [Thermococcus sp. AM4]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------ALYREMCPNCRGRISD-ERLSMRNPCESC-L-----NE-PIAI----------------DSYFELVSA----VRDALLNASRL-------K----DWE-RIY--RLESETREIEDFFRKAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMSVYY-AT-K--------G-K----KSYIVVPTTPLVIQT---IRKVQ-AI----IER-------T-GL---NVN-------------LAYYH-GNL--RKKEKE-EMLAKIES-GDY-D------ILITSAQWLARNFDEKL-KG--R-----HFDFIFVDDVDAFLKA-SKNIDRSLLLLGFTE--EIIGKA-------WEIIRLKK---QMA---RYLNGN-SQDKN-------DR-LKE----LNEA-------I-----------EKIQREIEEFKR--KN--D-IG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVVDSYL----KPSK-----------------DV-KEHVE------------ELLRKLG-K---GGLIFVPIDQGLSY-------AEELVDYLKER-GFAVELASSK---N---KKAVERFENGEADYLVGVATYYGSIVRGLDLPHLIRYAVFTGVPKFRFSI-------DL-ER-PTIYRALGLLSEVMDF-L-DDE------DRRKA-EKLHARLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PIENDF----HKTVLN-VFRELVEFLREVLKKEDVLKRLAED-PFV---SLV-KE-------EGK--WFI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKVFNGLVRQMR--WRFTE-FKM------V-----------------PF------------EE------L-------DLEKLLKEIDEDREKVKLV-ME-G
>RLG98823.1 reverse gyrase, partial [Candidatus Bathyarchaeota archaeon]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-----KFNFIFVDDVDSFLKS-PKNIDKILAILGFND--EIINMA-------FQLLDLRT---EAS---RMARMG-------------EN-PTA----VLRK-------I-----------ERIRSEIEHYKS--KN--Q-IG-IL--VVSGAT--MKAKRTKRIKLFEELLGFQIGFKPE-FLRNIKDLY-----LKEFEN----------------I-EKRVL------------ELIREFG-S---GCLIFVPSAIGKEY-------AVKLSEFLNQN-GVSAYVYRKM---D---EKILEEFTSGHYDALIGIASFRSPLARGIDLPERIRYTIFTGVPRMEIPL-------SW-KE-YNPTKILTLLKNIREF-L-DGK------QLDKA-SEIIAKLR-RIVP---LNKE---IQEKIK-E--------AIE-KGF-----QLE-GF----EEFARK-IISNEREFLREVIT-PEIIEKIRKS-KEI---SIK-QE-------DGM--FYL-IVADPVAYIQASGRASRMFAGGITRGASFLIV--DD--EKAFYSLQTRLK--FMFGE-ISW------S-----------------KF------------KI------E-------TAKKWFEKIDEDRRIIREI-KE-G
>RLG77943.1 reverse gyrase [Thermoprotei archaeon]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------MVTVVYRHGCPYCGERVTS-EELLSEGACTRC--------------------------------------V----AAQASVK----------------TFM-R----AFEEEVNELETFFKNVT-GFEPWSLQRAWIRRLVAGESFAMVAPTGVGKSTLLAVYVLYR-AI-N-------YK-W----KIYVVAPTKEIAAQL---WRRIE-EY----YDR-------A--K---KFS-------DSE-IRVLLYV-SGV---RNAK--KVKERIAS-GDF-D------ILITSAGFLSKNYEL-L-RK--WR-----FNLVVADDLDALLRN-SRNIDRILQLLGFDD--EEIKLA-------YEIAKAKQ---ELVV-ARLAGRE-------------HK-AQE----LEVF-------I-----------EEAKAKLKILLLE-----R-HC-QL--VVASAT--GRSRGL-KSKVLRELLGFEGGAVFE-YWRRIIDTYV----YMDE--PW----------------LEQVV------------EIVKRLK-S----GLVFVAQGMSP----------KVVAEYLKRH-GIRVEVVKSG-------RKSLDRFRNGEVDVLIGSASYYGILVRGIDEPLRVKFTIFIGVPRSGVKLEN-----AL----NSVRFMYVLLEELS-----RRG------VE--C-KEYLEFIV-NIL--KRASIG---YINVLN---------KLLAKGCV-----ECD-DKTAEILDKLLE-IKKWLYNTVKVMLGIE---GKIVLP-T-A---VVM-KR------GRDV---YV-YRPDPYTYIQASGRASRLLNGRKTLGLSLIVA--DD--YDLLSMLERRLK--SFVPE-LKF------V-----------------HI------------TA------I-------DLEKVVEQVQRSRI-LVAG-SS-K
>PNV77570.1 reverse gyrase [Candidatus Korarchaeota archaeon]
--------------------------------------------------------------------------MLK---------------------------------------------------------------------------------------AKFLSLCPGCDEDLYT-YVESC-----KC-TLS-S-------------------------------------------------------D--------LMM---DLRKSEEFMEFFKKCT-GFEASEIQRVWARRLIRGESFAAIAPTGTGKTVLGIVSSLFF-AR-N----------N----RSYLIFPTLLLVNQA---ENLSR-MF----SER-------A-GL---S-------------LEILSYT-SG-------RK-DLLDSITK-GEF-D------VLITTNQFLTRNFDL-I-RD--K-----RFGFIFVDDVDSMMKA-SKNLEKVLILLGFSE--DEIKER------------------------------------------------R----PREG------------------------------------EK--G-VI--FMASAT--GR-AGK-KTSLLRYLLNFDVGAIREGKLRNVVDISV----DRKD--------------------ANLLV------------DIVKKMGEK---GGLVFLRR---MEE-------ADEIAELLENN-GVSAEIARGS--D----PEMLERFRRGKTNVLIGAAKPYGVLVRGIDIPE-VRYTIFYGAPMYEISIS------NL-DE-VSPKVLSIALASLSGV-VGREAL----------------VLS-RQLR----------L------NP--------------------------------DEE-KIKRAKKIVSDFLSTNPEMENVL-------------FR-------NGE--AFL-CIPDMLTYIQGSGRSSRLRPGGLTKGASFLME--DE----LLDFFVRRAS--AY--D-IDF------V-----------------DI------------SS------V-------DLDSLRREIDEDRA------CK--
>RUM87542.1 reverse gyrase [Thermodesulfatator sp.]
---------------------------------------------------------------------------ML---------------------------------------------------------------------------------------FHLAHGCPNCGGKISD-ARLLAGLPCEAC-LPQ-GK-------------------------D-P---------CRLPEG--KL-------Q----GLS-LYC--QALSRVALFRKFFEKAV-GQPPSRLQESWAKRLFLGESFAIVAPTGSGKTTFGLLAALFS-Q-------------G----RALILVPTRLLCEQL---GQRLE-TY----AEA-------L-HL----SR------------RILAWR-GR--------Q-KDRQRFAS-GEF-D------LLVATAAFMYQHLEE-L-L---PL----SFALVFVDDVDAFLKR-SRHVEGLFRLLGFAE--EEIALA-------LK---------------------------------TRK-SEE----DYER-------L-----------RRIRER--P--------GR--G-QL--LISSAT--LRPRTS-RVLLFQHLLGFEIQRAVS-HLRNVYDLYE----DVPP----------------EAL-PERLL------------EILPHLG-T---GGLIFLSEGLGRSR-------VEEVTNLLRGK-GFKAVSYLEA--SP---EELMEGLKEGRYEMAVGLAHLANPLVRGLDLPEVLRYAVFLGVPCHLFPL-------KM-E--NSPLRLYTLLSALLPL-F-EGE------EELRA-SAHLRWLR-RYL---------------------------GLR-PED-----LPR-------YPRVAS-RVETIRGFLEQKLSDPAFREKLASS-EEV---FLE-ER-------DGE--LWV-VVGDAATYLQASGRVSRLSLRGVLPGLSLILV--DH--PRAFESLKRRLT-FYLGEA-PEF------R-----------------RL------------SE------V-------DLEEILRELTQTRRGLS----E-G
>PVU73943.1 reverse gyrase [Acidianus hospitalis]
--------------------------------------------------------------------------MVT---------------------------------------------------------------------------------------SVFLKACPNCGGPLED-YRALAGLPCSKC-LPG-DISPFKNL------------------SIDEKIRL----IYNILVHENKL-------K----GYW-NLY--YYHQLSQEIIDYFKKIT-GNEPWSLQKLWLRRLVESSSFSMSAPTGMGKTTTIIVYSTYL-QN-S--------N-K----NVLYIVPTKSLMQQI---CEKME-KI----GDK-------T-SC-------------------------GKV------------------GS---G-----ISIVTVNYINRNFEE-I-KEY-------RPDFVAVDDADAIVKS-GKTVDRLVTLMGIPQ--EVYEDA-------IKLVKLKR---LLAI--------------------EEK-RDE----IETK-------I-----------AEIESRISKYYGT-------AS-QL--VVASAT--LRPKGI-KQKALKYITGFDVSTAQI-YARNIIDAFT----------------------------SSSVV------------DIVNKLG-S---GGLILVSKEYGKDK-------IKEVNESLKEL-GFKTAIALSG-------RKFLEKFSSGEIDIIIGSASYYGVAVRGIDEPKRLKYVIFYGVPKSRVRLSQ-----AI----YNPY----TLLKISKL-F----------------NVNID--DNLILS---LSPS---EAQLIK---------LAFL-KSQ-----KLT-G----KLGEIQK-ILEGKIDEIKSALKAV-SNEVISDT---F---LIR-KI-------GKE--FYI-EYPDAITYLQGSGRSSRLLNGGLTLGLAITII--DD--FKLYEMLKRKLQ--YMIYN-FNP------T-----------------NF------------DS------L-------DIVKVKNEIERSRND---------
>WP_014026509.1 reverse gyrase [Pyrolobus fumarii]
--------------------------------------------------------------------------MA-------------------------------------------------------------------------------------KLTLLYEAGCPNCRGRIDE-ERLIKGLPCWEC-LPL------LPEA----------ERYLSGLDWRERVLA----VARLLEEHGKL-------E----GWA-WLA--REEDELSIFERFFERAT-GSRPWSVQRQWARRLLRRESFAITAPTGTGKTTLLAVYALYS-AV---------NG-S----RVYYLLPTSSLAKQV---AERLQ-LL----AHN-------A-AV---R-------------KRIVYYH-SLL--RASEKR-AQLEAIEN-GEY-D------ILVTTTAFLSRRWGL-L-ER--TM-----FDTIIVDDVDAILRD-SVNVERILMLLGAKP--DEIRAA-------TRLVKLSL---------RVRANPAL----------ARR-YAS----EIEE-------L-----------KRVVNGVAGRL----------G-QL--VVASAT--GRARGF-KRLVLGKLLGLSVGSIAG-YARNIAEYKL----LASSPEDA----------------IEKLV------------ETVAKMG-P---GGLVFVAKPLGVET-------AKLVVNRLGER-GVRAGLAIAG-------KRVIEKFERGEYDVLVGVASYYGVMVRGLDMPYRVAYALFLEPPFNRTPIEK-----AL----QSPRRILALAKALD--------------------VEGYREYA-RIL--SKMTPD---EVELLR---------AVLQ-GRL-----EAG-GRLAEAAEKARS-LASAILEKLRSVT------SEVPAG-Y-S---IL--TV------SSSG--AYV-ATPDPYTYIQASGRTSRLIKGYMTRGVVIVVS--SA--PLLLERFEDRLA--RLLAG----------F-----------------EL------------RE------Y-------NEKEVLEELEKAWESRRAP-AV-S
>PVU77116.1 reverse gyrase, partial [Acidianus hospitalis]
----------------------------------------------------------------------------M------------------------------------SEELPN---------------------------------------------LVYMNSCPNCGGEITA-NRLYKGSACEKC-VKE-DIQFNSVYD-----------------------------LALYLLKNRNL-------V----NLR-SSY--EILKELKEVERLFKRVL-GSPPLGPQRSWIVRALRGESFAIIAPPGLGKTTFGILMSLYF-AE-K--------Q-R----KTLMIFPTKTLVNQV---VQRIQ-EM----SKS-------L-EE---------------V-PKLAYYY-SGI--TQSQKG-ELNKILES-GDF-D------IFISTSRYIINNVDY-I-STK-------DYKYLFVDDVDSVLKS-SKSASAVLKLVGFTE--DDIQNV-------RELLRKSK---N-------------------------S--EE----VYDE-------I-----------RKIREKKTG-----DK-------IA--IFSSAT--IT-KGN---PVFSALMGFRPGSAVI-YLRNVIDSYVQ---LPSA--------------TDEEI-IDIVN------------KIVNKLG-S---GGLIFVPIDKGVSF-------ANEIASSISG---LKAEAISSTS------ITKLDKFEKGEIDVLVGVATHYGILVRGIDIPWRIRYAIFAGIPRFRFKIG---------ET-MHPLAMLKMLTLISLV-S----------KDEEV-TKILRIVR-NKL--RRISPA---ALVMLA-N--------SVK-SGK-----IE------------DK-YIQEAYDLTNKYLRNEEILEKIAEI-GEI---SI-----------NNG---YI-SSPDYLTYIQASGRTSRIFGGELTTGLSVLLV--DN--PRLFELLNRRLS--IVLDE-VSW------N-----------------PF--------DIDNDK------IGN----NNLHEILKRIDSEREKIRKI-KKEG
>RUM60663.1 reverse gyrase [Persephonella sp.]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------IIYKSMCPNCLGDISS-DRLEKGLPCENC-LPE-E---------------------------VP-VNE----VC------DFI-------G--YGQFR-NIC--DLWNKLKDFKKLFKELI-KNDLWSIQETWAIRYFLNTSYALLAPTGVGKTTFGLILSKFL-TE-K-------EN-K----KVYLIFPTQVLVNQA---YDRLI---------N-------F-NV---SSE------------RIVAYS-DRFAKSKKKQR-KLKERIKA-QDF-D------ILITTTMFLYRNVDI-I-P---KG----VYSLVFVDDVDSILKS-AKNIDKVLMLLGFSE--EDIEKT-------LKFISFKQ---KL-------------FSR------KNL-TEE----DLES-------Y-----------RKFQEEINN-IS--KK-RK--G-AL--IVSSAT--SNPRSK-RVSLFRELLGFEVGKPSL-TLRNIVDTYE----KV----------------EEEEL-WEISV------------DKINKLG-K---GGLVFLSSSETVER-------LNEYVDYLREK-GINAISYEDL--M-----DNLEKFKSGEIPVVVGFASYRNPIARGLDLPDVIRYALFVGVPKLQFNI-------RF-E--EEFIHLYYFLLTLTPF-L-IKKRLVDENKIKEL-YEYIRFLK-VYS---------------------------FIP-FEK-----LDK-------NK--QE-KLLRIKDFVKNLVEEENIYAQIKNS-PEI---TLK-KV-------NGS--FIL-ITADITGYIQASGRTSRLYAGGLTNGLAYLLV--DD--EKAFYSLQKKAK--WFSED-IQF------K-----------------PV------------EE------I-------DLERLLREIDEDREKVKKI-LA-G
>PSN92192.1 reverse gyrase [Candidatus Marsarchaeota G2 archaeon OSP_D]
-------------------------------------------------------------------------MTEL---------------------------------------------------------------------------------------AIFVSACPNCGGMITS-SRLERGLPCEKC-LPE---------------------PVDPATRSIEEWHSL---VASQLDRQGTLN-----------RYR-EIV--NLEDRAKEFVNVFHSLT-SREPWSAQLTWAKRCLRGESFSIIAPTGVGKTTFLSVLAVYM-AR-M--------G-K----RVLMVSPTALLARQT---AGWVK-RY----SAV-------Y-DH-------------T---IKVAELH-GEE--TGKAKR-EALSMVDD-ASA-N------IVVVTAAGLGNLFER-L-LKI-------GFGLILVDDVDALLRK-SVNIDRVIRLLGFSE--EVQGIA-------TEAILLRI---RLA---RLFAQG--------EVR-TEE-VDS----LLSR-------Y-----------KTLRKQIDEYKN--TH-SN-LG-QL--IVSSAT--ARPRGL-KVKVFRELFGFDAGSSAT-YLRNIVDV--------EAKL-------------DDDV-LGQVV------------SLVKRLG-R---GGLIFVAKDYGRET-------AKKIEEALNQA-GVKASQTSSYF------HKRVDEFASMKIDVLVGPASYYGKLVRGIDLPQSVRYTVFVGVPKFSSRLED--------EE-LSPLGIIRLLYAMSEL-IRDPI------ERQKT-FQQAVKLR-KMV--QNLSPS---DLRMVE-LA--------IK-ENR-----QLT-GY----LGQVQE-EIGVGRMIFHNQLATPNMLHELTQS-DRL---IIQ-ET-------PEG--PLV-LAPDVKTYIQASGRSSRLFGGKLAKGLSIVLV--DN--PRVMSALQRSMQ--IASSN-TKWY-----------------------KL------------EE------L-------DLDEVLREIDEDRRFNAKAKSE--
>GBD34450.1 Reverse gyrase [bacterium HR35]
--------------------------------------------------------------------------MQK-----------------------------------EIEDL-F---------------------------------------------TFYLEICPIDKAGAFS-KEIFNYGLCERD-------------------------FSFFKKSLWEIKES-------EIDQ-SLL----NFYSQ---NY-------EVYKKLKEYKDFFEKNL-GFPPFKLNLYWAQRVFKHESFTIIAPTGIGKTTFGIAISHFY------------PG------KVYYLVPSKILLAEI---ERKLN-LIK---SNK-----------------------------KILVIK------KPEDKE-----KLLS-GDF-D------ILVTTSHFLHKNFDN-L-PK--------NFELVFIDDSDSLIRQ-PKNIDKVLKLIGVTD--EEINQA-------LEIISKKR---QAK---------------------NFE-DYQ----KIDKL-----EI-------------------------DP-KT-KG-IV--IAASAT--LTPKTK-RINLFREILKFEIG-SSSTYLRNIEEVYQ----LVS----------------KDNL-WLESI------------KWIKKLG-D---GGFVFLSDDYNKQD-------LENYLSLLKEN-GITAVSYEKFN------SKNLKKFLDDEIQVVVGFSNIKNPLTRGIDLPQKVRYALFIGVPKFILSL-------KI-S--FSPLQLFWISLTLREF-L-EEM------EKNFI-NRHINFLK---------------KISYLK-EE------EILA-------------------NKILKE-RIEPLRNFLIEKINSAEILEKIKNH-PRL---VLE-KR-------KEE--FVL-LISDPRGYLQASGRTSRLFPLGLTKGLALLLT--EN--EKLLRHLEDKLK--IIGYQ-TKF------K-----------------EV------------KE------V-------NLEEILKKIDEDREIVKRV-FK-G
>WP_062370318.1 intein-containing reverse gyrase [Thermococcus guaymasensis]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------ALYREMCPNCEGRISD-ERLYMRNPCESC-L-----NE-PIVI----------------DSYFELVSA----VRDALLNANRL-------K----EWE-KIY--RLESESREIEDFFKKAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMSVYY-AT-K--------S-K----KSYIVVPTTPLVIQT---IRKVQ-AI----IER-------T-GL---DVK-------------LAYYH-GNL--RKKEKE-EMLARIES-GDY-D------ILITSAQWLARNFDEKL-KG--K-----RFDFIFVDDVDAFLKA-SKNIDRSLLLLGFTE--EIIDKA-------WEIIRLKK---QMS---KYLNGR-AQDRD-------ER-LKE----LNAQ-------I-----------EKLQREIEEFKR--KN--D-IG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGKS-ALRNVVDSYL----KPSR-----------------DV-KEHVE------------ELLKRLG-K---GGLVFVPIDQGLSY-------AEELVNYLREK-GFAVELASSK---N---KKAVERFENGEADYLVGVATYYGSIVRGLDLPHLIRYAVFTGVPKFRFSI-------DL-ER-PTIYRALGLLSEIMDF-L-DDE------DRKKA-EKLHARLR-RLI--RNIPQF---ELLKIE-E--------ALV-EGL-----PLENDF----HKTVLN-VFRELVEFLREVLKKEDVLRRLAED-PFV---SLV-KE-------EGK--WFI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKVFNGLVRQMR--WRFTE-FKM------V-----------------PF------------EE------L-------DLDKLLKEIDEDREKVKLV-ME-G
>BAN90338.1 reverse gyrase [Aeropyrum camini SY1 = JCM 12091]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSLREVREFESYFAAKS-GSRLWSAQRSWAKRLVKGDSFAIIAPTGVGKSTLLTVYAAYI-AA-V-------KG-G----RVLYLVPTENLVRQV---HARLE-E-----IEP-------G-L--------------------ATAYY-SRM--PAKAKQ-ASIDEISR-GEA-R------LLVATTGFLSRRFDL-L-YP--KY----RFNLAIVDDVDSLLRN-SRNVERVLLLTGFTE--EAVEAA-------YSLVKARV---KLYR-ALS-SGAG-----------DSI-VSK----LEQE-------I-----------ASLEARLRLSLSE----TS-PG-QL--VIASAT--GRPRGL-KHLIFKELLGFEVGGGSD-YLRNIVDAYV----IDADI-------------------VGRAV------------DIASDLG-D---GVIVFVSQRLGKDA-------AKLIAERLRER-GVSVALALTGA------RRPVEAFARGEAQVLVGMASRYGVIVRGLDIPERSRYAVFLGAPSTKTPLLE-----AL----YSPRRMLVFLSLAQ-----DSG------VE--WAGEAFRRLS-RLL--ERVV-----DTSIVS---------LAAR-GKL-----EAH-GPAGEAAEIIRE-AAPRLAEWLAEEARLRG--GLLRVG-G-L---VV--DP------SG----PYL-VIPDAPTYIQASGRVSRLYKGVMTRGLSIVVE--ES--PEYVEALGERLK--WTTSS-R-L------Q-----------------PL------------DQ------V-------DMEKLEREIEESRR---------G
>RLG77032.1 reverse gyrase [Thermoprotei archaeon]
----------------------------MVGVLALNSVVEI----------------------------SDAK--P-------------------------------------------------------------------------------------VVRGIYRGLCMNCGGEIED-LRLLYGLPCSRC-LPL---KE---------------------LRRFNSFRE----LAAKVVKLRKG-------S----MLD-HMA--KVEGFVQDLESVFRKCV-GSEMWSIQRTWAYRVAQKQSFAMIAPTGVGKTTFGLVVALYL-AM-K--------G-L----KTYIVVPTTVLVEQY---EQKLQ-EF----SEK-------L-GF---LPV-------------VIAIH-SKL--PSKRRA-ELEEALKQ-GSF-D------IVITTTMYLQRKFES-VLR-------GKKVDLVFVDDVDAVMKG-SKAIEYILQLIGFDE--SDIEMG-------YRSMRLRV---RLA----------TATEK------EQH---K----LFAE-------F-----------ESIQQSLRRKRE------R-TG-ML--ILSSAT--GRARGR-RVKLFRELLGFDIGGRAE-VYRNVVDVYV----EP--KK-------------D-PL--EVLL------------ELVRKLG-R---GGLVYVPVDRGIEE-------AERVAAYLRNH-GIAADTLVSG---K---ISNLDRFANGELDVLVGVAVFYGLLVRGIDLPEHVRYAIFLGVPRHKISL-------RL-EE-PSPQNMLRLSTVLVEV-V-DEG------TRREI-MMYLPVLR-RIM--RRYSPQ---SIAEMV-K--------RLV-AGE-----KPR-SR---EE----E-TLVKLHKILRDVLLRREIIESLRKY-PRA---TVI-EE-------EGR--LFL-LIPDAATYVQASGRTSRLFAGGITRGLSVVIV--DD--VRLLHGLEYRLK--WYIED-FSF------K-----------------PL------------EG------V-------DLGEVIKQIDEDRELVKAV-RQ-G
>WP_012663553.1 reverse gyrase [Nautilia profundicola]
--------------------------------------------------------------------------MLH---------------------------------------------------------------------------------------IIYKNECPRCGGDISS-VNLNKGMFCDEC-MKS-KK-----------------------KE--W-NLE----NC------ENL-------L----NYE-KYC--IADKKVNEFNEFFKFKC-GNELNSIQKMWAKRFFLDNSFALLASTGIGKTTFGLLLSAFV-KN------------------SYILFPTKLLVAQA---AEKYK---------K-------W-GI---EF---------------VAYM-GK--------K-SEKELIEK-GEY-D------ILITTTQFLYKNRSL-I-K---R-----NFELIFVDDVDSILKS-GKKIADILTLLGIDK--NSIEKT-------YELIKNQK---Y-------------------------------------------------------------SEIKS-VS--KK-----G-NL--IVSSAT--ANPKSK-KILLFKYLLGFEVSRPNF-NLRNIEDLYD----E-------------------NYS-WDHSV------------KWINELG-R---GGLLFLPGNETKDT-------LYEYIDFLNTK-NIKAYSYEDF--E-----KHLEEFKEGKC-FFVGFASYKNPLARGIDLPEYIKYTLFVGVPKIEFNL-------K--D--ENFRAFYFIMLSLLPY-L-VKNNL-SQKEVSEI-QNDLNYLK-KYI---------------------------YLS---K-----INV-------NT--QQ-KIADILIRFKNTVKKYE--DIIKTA-ENI---SFD-GE-------------KF-IIADVTGYIQASGRSSRFYKGHLTKGLSLLLV--DN--KKAFYSLKKKLK--WFGE--IEF------K-----------------NV------------ED------V-------DIKKVLTEIEKSRT----------
>WP_012083127.1 reverse gyrase [Nitratiruptor sp. SB155-2]
--------------------------------------------------------------------------MID---------------------------------------------------------------------------------------LVYKGLCPNCGGDICS-DRLDKGLLCKRC-MPK-E-------------------------------GE----PC------EVL-------K--EGEFV-KVC--EVEQRSVEFEAFFKEKN-GFLLRQIQKSWAKRFFLGHSFALLAPTGVGKTTFGLSLASFL-D-------------Q----KSYLLFPTQLLVNQA---VEKLR---------L-------L-GI---EP---------------LFYD-SGFSKSKK--D-EVKAKIAS-GDF-E------ILVTTTAFFYKNFDS-I-P---K-----AFGFVFIDDVDSILKS-ARNIDKVMLLLGFSQ--EDIDAA-------MQFIDHKI---K-----------------------GDL--------SYEE-------F-----------EQWQAKIEA-IR--SH-AK--A-QL--IVSSAT--ANPRSR-RVGLFRELLGFEVSRPSI-TVRNVEDLYE----K------------------PEKL-WERSV------------ELVERLG-R---GGLLFLPGNETKER-------LQEFLAFLEQK-GVKAQSYEDF---------DAKAFEEGEVEVLVGFASYRNPLARGIDMPATIRYALFVGVPKLEFTL-------DI----TKHTSLYFFLLALLPV-I-RNHPNFH-----QF-MQYVNYLK-RLV---------------------------RVP-TER-----LNE-------KA--KA-RVQTIYHDILAILDE-ELIDAINKT-PDV---SLV-KE-------DEY--FKI-ITADVTGYIQASGRTSRLYVGGLSKGLSYLLV--DS--EKTFSSLQKKVR--WFSEE-IVF------K-----------------SA------------KE------A-------DIDAILKIIDEDRKKIALA-LQ-G
>WP_012676084.1 reverse gyrase [Persephonella marina]
------------------------------------------------------------------------MSAIP---------------------------------------------------------------------------------------IVYKDICPNCGGEITA-ERLEKGLLCESC-LPE-E---------------------------IP-RED----IC------GIL-------G--YGRFV-SIC--ELWDKVNDFKSYFKGII-NNDLWSIQETWTKRFFLNISYALLAPTGIGKTTFGLVLSKYL-SE-K-------EG-K----KTYLIFPTQVLVNQA---YDRLV---------S-------F-GM---DPE------------KLLAYS-TKFAKTKKKQE-ELKEKIKN-NQF-D------ILITTTMFLYKNIDI-I-P---KG----EFSLVFVDDVDSVLKS-AKNIDKILMLLGFSE--EDIQDT-------LKFITFKQ---KI-------------FRQ------GQP-EEK----DLEI-------F-----------NRWQEKINR-IS--QK-RK--G-VL--IVSSAT--SNPRSK-RVNLFRELLGFEVGRPSL-TLRNIEDLYE----K------------------PDDV-WETSV------------ERIKKLG-S---GGLVFLSSSETRET-------LERYVKFLNEK-GINAISYEDL--M-----DSLEKFRSGEIPVVVGFASYRNPIARGLDLPDVIRYALFVGVPKLQFNI-------RF-E--EEFIHLYYFMLTLTPF-L-IKKKLIDPQEVRQL-YEYINFLK-VYA---------------------------FIP-EEK-----LDR-------EK--AE-RLREIQVYVKSIVEKPEVFDQIKDS-PEI---TLK-KT-------DEG--FIL-ITADVTGYIQASGRTSRLYAGGLTKGLAYLLV--DD--DKAFYSLQKKVR--WFSED-IQF------K-----------------PA------------DQ------V-------DLEKILKEIDQDRENVRKV-LS-G
>HCB70191.1 reverse gyrase [Persephonella sp.]
---------------------------------------------------------------------------MP---------------------------------------------------------------------------------------IVYKDICPNCGGEITA-ERLEKGLLCESC-LPE-E---------------------------IP-RED----IC------GIL-------G--YGRFV-SIC--ELWDKVNDFKSYFKGII-NNDLWSIQETWTKRFFLNISYALLAPTGIGKTTFGLVLSKYL-SE-K-------EG-K----KTYLIFPTQVLVNQA---YDRLV---------S-------F-GM---DPE------------KLLAYS-TKFAKTKKKQE-ELKEKIKN-NQF-D------ILITTTMFLYKNIDI-I-P---KG----EFSLVFVDDVDSVLKS-AKNIDKILMLLGFSE--EDIQDT-------LKFITFKQ---KI-------------FRQ------GQP-EEK----DLEI-------F-----------NRWQEKINR-IS--QK-RK--G-VL--IVSSAT--SNPRSK-RVNLFRELLGFEVGRPSL-TLRNIEDLYE----K------------------PDDV-WETSV------------ERIKKLG-S---GGLVFLSSSETRET-------LERYVKFLNEK-GINAISYEDL--M-----DSLEKFRSGEIPVVVGFASYRNPIARGLDLPDVIRYALFVGVPKLQFNI-------RF-E--EEFIHLYYFMLTLTPF-L-IKKKLIDPQEVRQL-YEYINFLK-VYA---------------------------FIP-EEK-----LDR-------EK--AE-RLREIQVYVKSIVEKPEVFDQIKDS-PEI---TLK-KT-------DEG--FIL-ITADVTGYIQASGRTSRLYAGGLTKGLAYLLV--DD--DKAFYSLQKKVR--WFSED-IQF------K-----------------PA------------DQ------V-------DLEKILKEIDQDRENVRKV-LS-G
>BAJ46912.1 reverse gyrase [Candidatus Caldiarchaeum subterraneum]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M----AAK-------H-GE---KAPK------------IAGYF-SGM--KKSEAE-EMLQKIRD-EEF-N------ILVTTDRFLNTRFEL-L-RG--K-----KFSFIFVDDVDSFLKS-ARNIDKVLLLMGFDE--EEIERQ-------LSLVSRRS---EKN---EA---G-------------E---------------------------------HASREIA-------K--P-DS-IL--LVAGAT--AKGRRTKRIQLFRRLLNFEPGGSIE-FVRNISNMY-----LRPSKN----------------M-WEQVA------------ELVKTHG-G---GCLIFVPQTAGVES-------AKELAKFLNSQ-GISAYAYERM---D---AKMLGRFELGEYDVLVGVASRRSPLARGIDLPERIRYVIFAGVPRRELNV-------SW-RE-HRPSMLLSLLRNLYSI-L-REK------NESEL-VQVTGMLK-KCVP---TDRE---VLEIVR-E--------GLE-SSR-----QPE-GF----AGYVYS-AVTRAHQLLKTYIG-EEELRRVAEN-LDM---RLR-VD-------ENG--VSI-ILPDIDGYIQASGRSSRMYAGGITRGISILIV--DD--EKAFRGISRALE--TIYEE--TF------Q-----------------EY------------TL------E-------QAREEFKQCDRDRQFLREI-RT-G
>WP_010477191.1 intein-containing reverse gyrase [Thermococcus zilligii]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCAGGISD-DRLVMKNPCAEC-L-----DE-PVQA----------------DSYFQLVSA----VRSALNLRGTL-------R----EWE-RIY--RLESQVREVEELFKKAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMALWH-AT-K--------G-K----KSYLIVPTTPLVIQT---VKKIN-SM----GER-------L-GL---NVK-------------LAYYH-GSL--NRKEKE-EMLALIDS-GEY-D------ILVTSAQWLARNFEDRL-KG--R-----HFDFIFVDDVDAFLKA-SKNIDRSLYLLGFNE--EVIQKA-------WEIVRLKK---GMG---RYLNGN-SEDKN-------GK-LRE----LDKQ-------I-----------EKIQREIESYKR--EN--R-VG-VM--IIASAT--GSARGD-RIKLYRELLGFEVGSGKS-ALRNVIDSYL----KPGR-----------------DV-REQVA------------ELLERLG-R---GGLIFVPIDQGLGY-------AEELVRYLRER-GFRVELASSK---N---RKAVERFENGEADYLVGVATYYGSIVRGLDLPHLIRYAVFTGVPKFRFSV-------DL-ER-PTIYRALGLLSEVMDF-L-GDE------DRRTA-ERLYSRLG-RLI--RNIPQF---ELLRIE-E--------ALA-EGL-----PIENEF----HNHVLG-VFRELVEFLRKALRKEEVLKKLAED-PFV---SLT-EE-------GGK--WFI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLLV--DN--EKVFNGLVRQMR--WRFME-FKM------V-----------------PF------------EE------L-------NLGEVLRQIDEDREKVRLV-ME-G
>WP_012718792.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MIN---------------------------------------------------------------------------------------VMYKNSCPNCGGDISA-DRLLNGLPCETC-LP--YINGIDGV------------------DNISKVKA----LYNILLDNDKI-------K----NYW-NLY--YNITTFETVFKYFKDKT-GYEPWSLQKLWLRRLVSNQSFTMSAPTGLGKTTTLMTYSVFI-G-------------Q----DVVYIVPTKSLMEQV---CKRLE-KL----GAQ-------V-SC-------------------------GKV------------------DQ--RK-----VSVITISYLNKNANS-I-TSY-------KPNFVAIDDADAVIKS-GKTTDRLVSLLGIPN--DVYESA-------IQLIRLRN---KYYF--------------------SNEFTEE----IKEK-------I-----------RELELKIAEFKDK-------IS-QL--VIASAT--IRPKGI-KQKALRLLTGFEPSSIQL-YARNIIDTYT----------------------------DNLDL------------SIVKELG-S---GGLILVSKEYGRSR-------LNEIKKYVEDL-GFNAKLAISG-------RKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKIKAKLFD-----AL----SNPF----TLLRVGKM-I----------------GVNFSELQNKILV---LSPS---ETQLLK---------FSII-KGE-----TIN-YQ---KLDQLRQ-ELLYYISLVKDKLKEIGEETLISDN---F---VIT-KQ-------NTN--YYI-IYPDMITYLQGSGRASRLYNGGLTLGFSIILV--DD--KHIFEILKKKMQ--KLFPN-TNF------T-----------------SL------------SN------I-------NLSEIKTKLEESRKE---------
>WP_016730803.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MIN---------------------------------------------------------------------------------------VMYKNSCPNCGGDISA-DRLLNGLPCETC-LP--YINGIDGV------------------DNISKVKA----LYNILLDNDKI-------K----NYW-NLY--YNITTFETVFKYFKDKT-GYEPWSLQKLWLRRLVSNQSFTMSAPTGLGKTTTLMTYSVFI-G-------------Q----DVVYIVPTKSLMEQV---CKRLE-KL----GAQ-------V-SC-------------------------GKV------------------DQ--RK-----VSVITISYLNKNANS-I-TSY-------KPNFVAIDDADAVIKS-GKTTDRLVSLLGIPN--DVYESA-------IQLIRLRN---KYYF--------------------SNEFTEE----IKEK-------I-----------RELELKIAEFKDK-------IS-QL--VIASAT--IRPKGI-KQKALRLLTGFEPSSIQL-YARNIIDTYT----------------------------DNLDL------------SIVKELG-S---GGLILVSKEYGRSR-------LNEIKKYVEDL-GFNAKLAISG-------RKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKIKAKLFD-----AL----SNPF----TLLRVGKM-I----------------GVNFSELQNKILV---LSPS---ETQLLK---------FSII-KGE-----TIN-YQ---KLDQLRQ-ELLYYISLVKDKLKEIGEETLISDN---F---VIT-KQ-------NTN--YYI-IYPDMITYLQGSGRASRLYNGGLTLGFSIILV--DD--KHIFEILKKKMQ--KLFPN-TNF------T-----------------SL------------SN------I-------NLSEIKTKLEESRKE---------
>WP_012711269.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MIN---------------------------------------------------------------------------------------VMYKNSCPNCGGDISA-DRLLNGLPCETC-LP--YINGIDGV------------------DNISKVKA----LYNILLDNDKI-------K----NYW-NLY--YNITTFETVFKYFKDKT-GYEPWSLQKLWLRRLVSNQSFTMSAPTGLGKTTTLMTYSVFI-G-------------Q----DVVYIVPTKSLMEQV---CKRLE-KL----GAQ-------V-SC-------------------------GKV------------------DQ--RK-----VSVITISYLNKNANS-I-TSY-------KPNFVAIDDADAVIKS-GKTTDRLVSLLGIPN--DVYESA-------IQLIRLRN---KYYF--------------------SNEFTEE----IKEK-------I-----------RELELKIAEFKDK-------IS-QL--VIASAT--IRPKGI-KQKALRLLTGFEPSSIQL-YARNIIDTYT----------------------------DNLDL------------SIVKELG-S---GGLILVSKEYGRSR-------LNEIKKYVEDL-GFNAKLAISG-------RKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKIKAKLFD-----AL----SNPF----TLLRVGKM-I----------------GVNFSELQNKILV---LSPS---ETQLLK---------FSII-KGE-----TIN-YQ---KLDQLRQ-ELLYYISLVKDKLKEIGEETLISDN---F---VIT-KQ-------NTN--YYI-IYPDMITYLQGSGRASRLYNGGLTLGFSIILV--DD--KHIFEILKKKMQ--KLFPN-TNF------T-----------------SL------------SN------I-------NLSEIKTKLEESRKE---------
>WP_016732476.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MIN---------------------------------------------------------------------------------------VMYKNSCPNCGGDISA-DRLLNGLPCETC-LP--YINGIDGV------------------DNISKVKA----LYNILLDNDKI-------K----NYW-NLY--YNITTFETVFKYFKDKT-GYEPWSLQKLWLRRLVSNQSFTMSAPTGLGKTTTLMTYSVFI-G-------------Q----DVVYIVPTKSLMEQV---CKRLE-KL----GAQ-------V-SC-------------------------GKV------------------DQ--RK-----VSVITISYLNKNANS-I-TSY-------KPNFVAIDDADAVIKS-GKTTDRLVSLLGIPN--DVYESA-------IQLIRLRN---KYYF--------------------SNEFTEE----IKEK-------I-----------RELELKIAEFKDK-------IS-QL--VIASAT--IRPKGI-KQKALRLLTGFEPSSIQL-YARNIIDTYT----------------------------DNLDL------------SIVKELG-S---GGLILVSKEYGRSR-------LNEIKKYVEDL-GFNAKLAISG-------RKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKIKAKLFD-----AL----SNPF----TLLRVGKM-I----------------GVNFSELQNKILV---LSPS---ETQLLK---------FSII-KGE-----TIN-YQ---KLDQLRQ-ELLYYISLVKDKLKEIGEETLISDN---F---VIT-KQ-------NTN--YYI-IYPDMITYLQGSGRASRLYNGGLTLGFSIILV--DD--KHIFEILKKKMQ--KLFPN-INF------T-----------------SL------------SN------I-------NLSEIKTKLEESRKE---------
>WP_014512599.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MIN---------------------------------------------------------------------------------------VMYKNSCPNCGGDISA-DRLLNGLPCETC-LP--YINGIDGV------------------DIISKVKA----LYNILLDNDKI-------K----NYW-NLY--YNITTFETVFKYFKDKT-GYEPWSLQKLWLRRLVSNQSFTMSAPTGLGKTTTLMTYSVFI-G-------------Q----DVVYIVPTKSLMEQV---CKRLE-KL----GAQ-------V-SC-------------------------GKV------------------DQ--RK-----VSVITISYLNKNANS-I-TSY-------KPNFVAIDDADAVIKS-GKTTDRLVSLLGIPN--DVYESA-------IQLIRLRN---KYYF--------------------SNEFTEE----IKEK-------I-----------RELELKIAEFKDK-------IS-QL--VIASAT--IRPKGI-KQKALRLLTGFEPSSIQL-YARNIIDTYT----------------------------DNLDL------------SIVKELG-S---GGLILVSKEYGRSR-------LNEIKKYVEDL-GFNAKLAISG-------RKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKIKAKLFD-----AL----SNPF----TLLRVGKM-I----------------GVNFSELQNKILV---LSPS---ETQLLK---------FSII-KGE-----TIN-YQ---KLDQLRQ-ELLYYISLVKDKLKEIGEETLISDN---F---VIT-KQ-------NTN--YYI-IYPDMITYLQGSGRASRLYNGGLTLGFSIILV--DD--KHIFEILKKKMQ--KLFPN-TNF------T-----------------SL------------SN------I-------NLSEIKTKLEESRKE---------
>ADM28742.1 reverse gyrase [Ignisphaera aggregans DSM 17230]
-------------------------------MSGINIVFDLG-------------------------GKGDEELLK-------------------------------------------------------------------------------------IPRGIYLGLCINCGGPIED-NRIIYRNACSKC-MNS---KD---------------------LVEVRDLEE----LAKHVTSLNPN-------G----RLN-YIL--TLNKFVKEFEEFFQKSI-GSKPWSLEISWALRVAQHQSFAMIAPTGVGKTTFGLVMTLFL-SY-K-------YG-K----KVYIIVPTTVLVEEY---EKRLW-QF----SEK-------L-GI---TLK-------------IIAAS-SKI--HGKRKI-ELEESIAS-GSF-D------ILITTSAFLQRNFND-VFKK--MLSNNIKMDLIFVDDVDAIIKG-SKAIDMVLQLLGFSE--EDISNG-------YKMIDLRR---RLL-----------QCEN------ARE-SSR----CYIDGKPIDVIY-----------EELQKKVLEKRE------R-CG-IL--IVASAT--GRARGK-RIKLFRELLGFSIGTAIE-VNRNVVDAYI----PIDNPA-------------E-II--DRLV------------SIIKILG-S---GGLIYVPLDLGQEY-------AVKLATELNSR-GIRAGVVISG---K---SEDLKKFIENELDVVVGVATYYGLLVRGIDIPERIRYAIFVGVPRHKISL-------TR-IE-YYPQTLLRLLSVLVDV-V-EDQ------MKDRV-LRNIAYLR-RIL--RRISPN---RIFDIV-E--------RLK-KGE-----KVE-DE---LA----G-IITNAYKLVNELLSDSKIIDRLKKH-ERV---SII-EE-------EGQ--LYI-LIPDAPTYIQASGRTSRLFMGGITRGLSIIFV--DD--TRLLRGLEERIR--VYIDD-FRF------Q-----------------SF------------NE------I-------NLEEILKQIDEDRRIVNLI-KR-G
>WP_012952814.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MIN---------------------------------------------------------------------------------------VMYKNSCPNCGGDISA-DRLLNGLPCETC-LP--YINGIDGV------------------DIISKVKA----LYNILLNNDKI-------K----NYW-NLY--YNITTFETVFKYFKDKT-GYEPWSLQKLWLRRLVSNQSFTMSAPTGLGKTTTLMTYSVFI-G-------------Q----DVVYIVPTKSLMEQV---CKRLE-KL----GAQ-------V-SC-------------------------GKV------------------DQ--RK-----VSVITISYLNKNANS-I-TSY-------KPNFVAIDDADAVIKS-GKTTDRLVSLLGIPN--DVYESA-------IQLIRLRN---KYYF--------------------SNEFTEE----IKEK-------I-----------RELELKIAEFKDK-------IS-QL--VIASAT--IRPKGI-KQKALRLLAGFEPSSIQL-YARNIIDTYT----------------------------DNLDL------------SIVKELG-S---GGLILVSKEYGRSR-------LNEIKKYVEDL-GFNAKLAISG-------RKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKIKAKLFD-----AL----SNPF----TLLRVGKM-I----------------GVNFSELQNKILV---LSPS---ETQLLK---------FSII-KGE-----TIN-YQ---KLDQLRQ-ELLYYISLVKDKLKEIGEETLISDN---F---VIT-KQ-------NMN--YYI-IYPDMITYLQGSGRASRLYNGGLTLGFSIILV--DD--KHIFEILKKKMQ--KLFPN-TNF------T-----------------SL------------SN------I-------NLSEIKTKLEESRKE---------
>WP_009992408.1 reverse gyrase [Saccharolobus solfataricus]
--------------------------------------------------------------------------MIN---------------------------------------------------------------------------------------VMYKNSCPNCGGDISG-DRLLNGLPCEAC-LP--YINGIDDV------------------DHISKVKT----LYNILLNNDKI-------K----NYW-NLY--YNITTFETVFKYFRDKT-GYEPWSLQKLWLRRLASNQSFTMSAPTGLGKTTTLMTYSVFI-G-------------Q----DVVYIVPTKSLMEQV---CKRLE-KL----GAQ-------V-SC-------------------------GKI------------------DQ--KK-----VSVITISYLNKNADS-I-VSL-------KPNFVVIDDADAVIKS-GKTTDRLVSLLGIPK--DVYESA-------IQLIRLRN---KYYF--------------------SNEYTEE----VKEK-------I-----------RELELKIAEFKDK-------IS-QL--VIASAT--IRPKGI-KQKALRLLTGFEPSSIQL-YARNIIDAYT----------------------------ENLDL------------SIVKELG-S---GGLILVSKEYGRSK-------LNEIKKYVEDL-GFNAKLAISG-------RKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKIRAKLFD-----AL----SNPF----TLLRVGKL-I----------------GIDFSKLQNKILI---LNPS---EVQLLK---------FSII-KGE-----SIN-YH---KLEQLRQ-ELLYYMSLVKDKLKEKVEDTLISDS---F---VIT-KQ-------NGN--YYI-VYPDMITYLQGSGRASRLYNGGLTLGFSIILV--DD--RHIFEILEKKMQ--KLFPN-TTF------T-----------------SL------------SN------T-------NLSEIKIKLEDSRKE---------
>WP_012713657.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MIN---------------------------------------------------------------------------------------VMYKNSCPNCGGDISA-DRLLNGLPCETC-LP--YINGIDGV------------------DIISKVKA----LYNILLNNDKI-------K----NYW-NLY--YNITTFETVFKYFKDKT-GYEPWSLQKLWLRRLVSNQSFTMSAPTGLGKTTTLMTYSVFI-G-------------Q----DVVYIVPTKSLMEQV---CKRLE-KL----GAQ-------V-SC-------------------------GKV------------------DQ--RK-----VSVITISYLNKNANS-I-TSY-------KPNFVAIDDADAVIKS-GKTTDRLVSLLGIPN--DVYESA-------IQLIRLRN---KYYF--------------------SNEFTEE----IKEK-------I-----------RELELKIAEFKDK-------IS-QL--VIASAT--IRPKGI-KQKALRLLTGFEPSSIQL-YARNIIDTYT----------------------------DNLDL------------SIVKELG-S---GGLILVSKEYGRSR-------LNEIKKYVEDL-GFNAKLAISG-------RKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKIKAKLFD-----AL----SNPF----TLLRVGKM-I----------------GVNFSELQNKILV---LSPS---ETQLLK---------FSII-KGE-----TIN-YQ---KLDQLRQ-ELLYYISLVKDKLKEIGEETLISDN---F---VIT-KQ-------NTN--YYI-IYPDMITYLQGSGRASRLYNGGLTLGFSIILV--DD--KHIFEILKKKMQ--KLFPN-TNF------T-----------------SL------------SN------I-------NLSEIKTKLEESRKE---------
>PMP61327.1 reverse gyrase [Caldimicrobium thiodismutans]
---------------------------------------------------------------------------ML---------------------------------------------------------------------------------------FYVLHGCPNCGGMISD-ERLSRGLPCENC-LKE-EEL----------------------ILEKEDLGS----VAEILRKKGNL-------K----DLE-IYA--KVEKEISYFKEIFEEVF-GSSPSSLQLSWAKRFYLGESFAIVAPTGTGKTTFGLLACLVN-Q-------------G----KSLIIVPTKVLVNHL---YERLL-AI----QER-------I-SKKDLREK------------IILPYT-GS--------K-KEKEILEN-KKV-D------LFICTQAFFHRNFEL-L-K---KL----DFSLIFVDDVDSFLKS-GKNVEHLFYMLGFTQ--KEIELA-------LK---------------------------------RDK-EEE----DFEK-------L-----------LKIKERHKK--------KL--K-RL--IVSSAT--LKPKTN-RALLFQNLLGFEITRFVS-TLRRVEDLYF----QPEKRD-------------FFYL-LDQVV------------EIVKKLD-P---PGILFIEEHYGRES-------VEKASEYLKEK-GLRIISYLET--DE---ENLLESLKNKKVDLALGLSHLSNPLLRGIDLPEVLRYVIFLGVPKHRFPLLREKEGFEL-P--LSSQFLHNLLLSLLPL-F-EEE------EKFLS-LAYINYLK-KYL---------------------------TLR-DED-----LPR-------YEGLLK-KVTEIRDFLSVKLRDEGFMEKLKNS-DEV---FLDIDE-------EGK--YYV-VVGNAQVYLQGSGRVSRLTARGLLPGFSLLII--DN--LKAFLSLKKRLR-FYLGEE-PEF------K-----------------KV------------AP------E-------DIPEIDKRIQRERETLK----E-T
>PVU78570.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MIN---------------------------------------------------------------------------------------VMYKNSCPNCGGDISA-DRLLNGLPCETC-LP--YINGIDGV------------------DIISKVKA----LYNILLNNDKI-------K----NYW-NLY--YNITTFETVFKYFKDKT-GYEPWSLQKLWLRRLVSNQSFTMSAPTGLGKTTTLMTYSVFI-G-------------Q----DVVYIVPTKSLMEQV---CKRLE-KL----GAQ-------V-SC-------------------------GKV------------------DQ--RK-----VSVITISYLNKNANS-I-TSY-------KPNFVAIDDADAVIKS-GKTTDRLVSLLGIPN--DVYESA-------IQLIRLRN---KYYF--------------------SNEFTEE----IKEK-------I-----------RELELKIAEFKDK-------IS-QL--VIASAT--IRPKGI-KQKALRLLTGFEPSSIQL-YARNIIDTYT----------------------------DNLDL------------SIVKELG-S---GGLILVSKEYGRSR-------LNEIKKYVEDL-GFNAKLAISG-------RKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKIKAKLFD-----AL----SNPF----TLLRVGKM-I----------------GVNFSELQNKILV---LSPS---ETQLLK---------FSII-KGE-----TIN-YQ---KLDQLRQ-ELLYYISLVKDKLKEIGEETLISDN---F---VIT-KQ-------NTN--YYI-IYPDMITYLQGSGRASRLYNGGLTLGFSIILV--DD--KHIFEILKKKMQ--KLFPN-TNF------T-----------------SL------------SN------I-------NLSEIKTKLEESRKE---------
>VCU54721.1 Reverse gyrase [Thermus thermophilus]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-GAPPWPLQRAWAARVVQGRSFAMLAPTGIGKTTFGLLTALWL-AR-E--------G-R----RSYLVFPTRLLVAQA---AERLR-A---------------L-RA------------------PFVAYT--------GKPK-EKEALLEG-----ERP----IGLFTVAFLYKNHAR-L-PR--------PVDFLFVDDVDSLLKS-ARNVDRVLELLGFAP--EDLEKG-------LSLIRLRR-------------------KN------PEE-AER----M----------A-----------EGLRRKA-----------R--G-VL--AVASAT--ARPRSP-RVHLFRELLGFEVGTPSF-ALRKV-----------------------------ADL-YEEAFGLSQEALWARGAEWARRLG-G---GGLLFLPGDLPKEA-------ALDLARFLRAR-GLR---AKAY--LE---PEALEAFRRGEADHLVGFASWRNPLARGLDLPGRVRYALFLGVPKLRFALGE--------D--LAPQELVRLGLALLPL-L----------EDPRL-KALVRSLA-R--R-PGLQEK---EVAPL-----------------------REA------LLERLAD-PAFRAR---------------VAES-PEVGLTFVG-EK-------P-----VL-VFADVTGYLQASGRTSRLTPAGLTQGLALLLA--ED--RKAFTALVRRLG---YLLE-VPP------R-----------------PV------------AE------A-------DLEALLKRVDEDRERLARG-ER-G
>WP_014513930.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MIN---------------------------------------------------------------------------------------VMYKNSCPNCGGDISA-DRLLNGLPCETC-LP--YINGIDGV------------------DIISKVKA----LYNILLDNDKI-------K----NYW-NLY--YNITTFETVFKYFKDKT-GYEPWSLQKLWLRRLVSNQSFTMSAPTGLGKTTTLMTYSVFI-G-------------Q----DVVYIVPTKSLMEQV---CKRLE-KL----GAQ-------V-SC-------------------------GKV------------------DQ--RK-----VSVITISYLNKNANS-I-TSY-------KPNFVAIDDADAVIKS-GKTTDRLVSLLGIPN--DVYESA-------IQLIRLRN---KYYF--------------------SNEFTEE----IKEK-------I-----------RELELKIAEFKDK-------IS-QL--VIASAT--IRPKGI-KQKALRLLTGFEPSSIQL-YARNIIDTYT----------------------------DNLDL------------SIVKELG-S---GGLILVSKEYGRSR-------LNEIKKYVEDL-GFNAKLAISG-------RKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKIKAKLFD-----AL----SNPF----TLLRVGKM-I----------------GVNFSELQNKILV---LSPS---ETQLLK---------FSII-KGE-----TIN-YQ---KLDQLRQ-ELLYYISLVKDKLKEIGEETLISDN---F---VIT-KQ-------NTN--YYI-IYPDMITYLQGSGRASRLYNGGLTLGFSIILV--DD--KHIFEILKKKMQ--KLFPN-TNF------T-----------------SL------------SN------I-------NLSEIKTKLEESRKE---------
>WP_068515122.1 reverse gyrase [Caldimicrobium thiodismutans]
---------------------------------------------------------------------------ML---------------------------------------------------------------------------------------FYIAHGCPNCGGRISD-ERLSLGLPCEKC-LSE-KTF----------------------LKGDLTLEE----AIQALEKNKKL-------R----DLK-LFG--RVEKEVYQFHRVFQEIF-GIAPSSLQLSWAKRFFLGESFAIVAPTGTGKTTFGLLACLLH-R-------------E----KSLILVPTKVLVNHL---YERLQ-DL----QEK-------T-SFEEIKTR------------RILSYT-GS--------N-QEKRLLEE-KSF-D------IFICTQAFFHKNYEL-L-K---MA----DFSLIFVDDVDSFLKS-GKNVDHLFHMLGFSQ--REIELA-------LK---------------------------------REK-EEE----DYAK-------L-----------WKIKEKHSK--------KL--K-RL--IVSSAT--LKPRTS-RTILFQNLLGFEVTRFVS-TLRRVEDLYL----EAEESN-------------LETL-LERAY------------TIIQKIG-S---GGLLFVEENAGREG-------VEKATQYLKEK-GLKVVSYLEE--KE---ADLLELLKEKEIDLAVGLAHLGNPLLRGLDLPFALHYVLFLGVPKHFFPLGKKGETLEL-P--LSTQFLHNLLLNLLPL-F-EEE------ERFKA-LSYINYLK-RYL---------------------------TLK-EES-----LLQ-------YEGLVK-RVSEIKDFIQERLLNEDFMERLKRS-DEV---FLDVKE-------DGK--YYV-VVGNAQVYLQGSGRVSRLTARGLLPGISLMLV--DH--PKAFLSLKKRLR-FYLGEE-PAF------Q-----------------KV------------TL------D-------GVLEINQRILKERSSLQ----E-S
>P74759.1 RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Saccharolobus shibatae]
--------------------------------------------------------------------------MIN---------------------------------------------------------------------------------------VMYKNSCPNCGGDISA-DRLLNGLPCETC-LP--YINGIDGI------------------DHISKVKA----LYNILLDNDKI-------K----NYW-NLY--YNITTFETVFKYFKDKT-GYEPWSLQKLWLRRLVSNQSFTMSAPTGLGKTTTLMTYSVFI-G-------------Q----DVVYIVPTKSLMEQV---CKRLE-KL----GAQ-------V-SC-------------------------GKV------------------DQ--RK-----VSVITISYLNKNADS-I-TSY-------KPNFVAIDDADAVIKS-GKTTDRLVSLLGIPN--DVYESA-------IQLIRLRN---KYYF--------------------SNEFTEE----IKEK-------I-----------RELELKIAEFKDK-------IS-QL--VIASAT--IRPKGI-KQKALRLLTGFEPSSIQL-YARNIIDTYT----------------------------DNLDL------------SIIKELG-S---GGLILVSKEYGRSR-------LNEIKKYVEDL-GFNAKLAISG-------RKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKIKAKLFD-----AL----SNPF----TLLRVGKM-I----------------GVNFSELQNKILV---LSPS---EAQLLK---------FSII-KGE-----TIN-YQ---KLEQLRQ-ELLYYISLVKDKLKEIGEETLISDN---F---VIA-KQ-------NTN--YYI-IYPDMITYLQGSGRASRLYNGGLTLGFSIILV--DD--KHIFEILKKKMQ--KLFPN-TNF------T-----------------SL------------SN------I-------NLSEIKTKLEESRKE---------
>WP_010884895.1 reverse gyrase [Pyrococcus horikoshii]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCRGAITD-ERLSNKNPCEGC-L-----SE-PILS----------------EDYNELIVA----VRNALKLRGTL-------K----DWE-ELY--RLNKEVSEIEELFEKST-GFKFWSAQRTWVKRIIRGKSFSIIAPTGMGKSTFGAFISIYF-AT-K--------G-K----KSYIVVPTTPLVIQT---VKKIE-SM----LEK-------A-NV---SVR-------------LVYYH-GNL--RKKEKE-EALEKIRN-GDF-D------ILITSSQFLATRFKELL-KD--K-----KFDLIFVDDVDAFLKA-SKNIDRSLIMLGFSE--EIIGRA-------WEVIKLKK---QLA---KLLQNE-KKN-E-------EE-IEK----LNKE-------I-----------EKIEDEIEEYKR--RN--K-IG-IL--IVASAT--GSAKGD-RIKLYRELLGFEVGSGRS-VLRNIVDTYL----LPEK-----------------PI-EEHVV------------ELLRKLG-K---GGLIFVPIDKGIEY-------AEELTDYLKSQ-GFKVELVSAK---N---KKGLELFEKGEIDYLVGVATYYGTLVRGLDLPHLIRFAIFTGVPKFRFSM-------DL-EQ-PTIYRVLGLMSEILEF-L-PEE------KKSEG-EKLYARLR-RLI--RNIPQY---ELMKIE-E--------ALA-EGL-----ELE-GF----HNHVLE-VFKQSVEFLREVLKDEEVIKKIAEN-PFL---SLK-EI-------EGK--LYI-EIPDVRTYIQASGRTSRLFAGGITKGLSVIIV--DD--QKVFNGLIRQMR--WRFVE-FDI------K-----------------KF------------EE------V-------NLKEVLKEIDRDREKVKLV-IE-G
>RLI90907.1 reverse gyrase, partial [Candidatus Altiarchaeales archaeon]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELFRKLLNFDIGLGAS-TLRNIEDILV----NSTN--------------------LETLE------------EIFAKMG-K---GGIIYTRS---QEE-------AKQLYEKLKEK--YEIGIVTAE--K----KSDYKLFESGDLDYLIGTAYYYGTLVRGLDLPERIRFVIFYKAPTFRVKFE------DV-D-----SCGIGTIRTLALV-FRDNPK-----------------LR-DFIP----------LLPLLD-KP-------------------------------KYAE-KLALLRKTLKEILKAETTNF---DA-RDI---CI------------KE--DEI-IFPDLRTYIQGSGRTSRLFAGGITKGASFLLE--DD--RSVLNAFVERAS--YY--D-IEF------K-----------------PL------------AE------V-------DFPKLLKEIDETRRKF----AK--
>RLF79459.1 reverse gyrase, partial [Thermococci archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYKGMCPNCEDKISD-ERLYKKHPCEIC-L-----ED-EIHS----------------DIYFDLITG----IREGLRVKNTI-------K----HWE-ELY--SLEKKLIEAEELFKNAT-GFTFWSAQKTWVKRLVRGKSFSIIAPTGMGKSVFGAFMSIYY-AK-H--------G-K----KSYIVLPTTPLVIQT---IKRVK-TF----AEN-------T-GI---DVN-------------LAYYH-GNM--KKKEKE-EMIQKIQT-GNF-D------VLITSGQYLARNFD-LI-KD--K-----KFDFIFVDDVDAFLKA-SKNIDRSLILLGFTE--EMIQKA-------WEIIKLKK---QMA---KYLNGN-RKNKN-------EQ-LKE----LNKQ-------I-----------SIIENEIREFKD--KN--K-IG-VI--IIASAT--GSARGD-RIKLYRELLDFEVGSGRS-ALRNVVDSYL----FPEN-----------------SV-EEHIK------------ELLKVLG-P---GGLIFVPIDQGIAY-------AERLTNYLQDL-GFKVELVSAR---N---KKGLQRFENGEVDYLVGVATYYGSIVRGLDIPHLIRYAIFTGIPKFRFSI-------DL-EQ-PTIYRVLGLMSEVMNF-L-ENE------DRKNA-EKLHARIR-RLI--RNIPQF---EILKIE-E--------ALA-EGL-----PLE-GF----SNHVLE-VFKEGVEFLRTVLKKEDVLKRIEED-PFV---SLK-KE-------ENK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVIIV--DN--EKVFNGLKRQMR--WRFAE-FEM------I-----------------PF------------HE------L-------ELEKVLQEIDANREKVKLL-ME-G
>WP_012717512.1 reverse gyrase [Sulfolobus islandicus]
--------------------------------------------------------------------------MIN---------------------------------------------------------------------------------------VMYKNSCPNCGGDISA-DRLLNGLPCETC-LP--YINGIDGV------------------DIISKVKA----LYNILLNNDKI-------K----NYW-NLY--YNITTFEIVFKYFKDKT-GYEPWSLQKLWLRRLVSNQSFTMSAPTGLGKTTTLMTYSVFI-G-------------Q----DVVYIVPTKSLMEQV---CKRLE-KL----GAQ-------V-SC-------------------------GKV------------------DQ--RK-----VSVITISYLNKNANS-I-TSY-------KPNFVAIDDADAVIKS-GKTTGRLVSLLGIPN--DVYESA-------IQLIRLRN---KYYF--------------------SNEFTEE----IKEK-------I-----------RELELKIAEFKDK-------IS-QL--VIASAT--IRPKGI-KQKALRLLTGFEPSSIQL-YARNIIDTYT----------------------------DNLDL------------SIVKELG-S---GGLILVSKEYGRSR-------LNEIKKYVEDL-GFNAKLAISG-------RKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKIKAKLFD-----AL----SNPF----TLLRVGKM-I----------------GVNFSELQNKILV---LSPS---ETQLLK---------FSII-KGE-----TIN-YQ---KLDQLRQ-ELLYYISLVKDKLKEIGEETLISDN---F---VIT-KQ-------NTN--YYI-IYPDMITYLQGSGRASRLYNGGLTLGFSIILV--DD--KHIFEILKKKMQ--KLFPN-TNF------T-----------------SL------------SN------I-------NLSEIKTKLEESRKE---------
>RUM58927.1 reverse gyrase [Persephonella sp.]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------MCPNCNGDISS-DRLEKGLPCVKC-LPD-E---------------------------VE-KDE----VC------DFI-------G--YGKFR-NVC--DVWEELNRFKRFFKEII-KNDLWSIQETWAIRYFLNISYALLAPTGIGKTTFGLILSKFL-VE-N-------FN-K----KVYLLFPTQVLVNQA---YDKLI---------N-------Y-GV---NHD------------KIIAYS-SKFAKSKKKQE-ELKNRIKN-GDF-N------ILITTTMFLYKNIDN-I-P---KG----IYSLVFVDDVDSILKS-AKNIDKVLMLLSFTE--EDINKG-------LEFIKFKQ---KV-------------FSK------KSI-TEE----DLEN-------Y-----------RRFQEEIFK-IS--KK-RK--G-VL--IVSSAT--SNPKSK-RVNLFRELLGFEVGKPSI-TLRNVEDVYE----EA----------------IDKDL-WELSI------------DKIKRLG-K---GGLVFLSSSETVEN-------LHRYVEFLNQN-GINAISYEKL--M-----DNLDKFKSGEIPVVVGFASYRNPIARGIDLPDVIRYALFIGVPKLQFNI-------RF-E--EEFIHLYYFLLTLTPF-L-VKKKLIDDKEIKTL-YEYIRFLK-IFA---------------------------FIP-YEN-----LDK-------EK--QE-RLLKIRDFVKSLVERNDIYDAIKNS-PEI---TLK-KV-------NDS--FIL-ITADITGYIQASGRTSRLYAGGLTKGLAYLLV--DD--EKAFYSLQKKVR--FFSED-INF------K-----------------PI------------ND------I-------DLEKILNEIDKDRERVKKV-LA-G
>BBD71955.1 reverse gyrase [Sulfodiicoccus acidiphilus]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNV-----------------------------LLATLSRSGKL-------K----FLR-EEE--MVLRELDSLSTYFRAMT-GSTLTGPQRSWALRFLRGESFSITAPPGMGKTTFGLSASIFN-AV-R--------G-A----KSVLVFPTKSLVSQA---EVKLR-DVT----------------------------------SKL------GL--SVKFVS-TVKKEPEG-EDF-H------ILLTTSKYAMLH-RE-L-ANH-------DFRMIFVDDVDAVTKS-RKSTYMLLELAGFSK--DELSSL-------RDASREGD---SL------------------------------------K-------V-----------REIRERVLN-----GK-------VV--ILSSAS--VT-RVT---PIISSALGLRPGGTAI-YSRNIVDTYME---FPS------------------DV-AVELK------------KVLRTLG-T---GGLVYVSVDKGMEL-------AKRIHEELSE--ELRVGLVNSTS------SKAVERFRGGELDYLVGVATHYGPLVRGLDMPSRVRYAIFVGVPKFKFVLG---------EK-MHPLAALRLLVTLASV-K----------RLTEL-YSLVGQMR-KKL--RTLSPS---ALAVVA-N--------AIR-EGK-----LE------------DK-VFARVYDVVQRSLEDKETLQRMMEA-GGF---VL-----------QDG---LL-LLPDYVTYLQASARTSRLLGGGLTTGLSVVLV--DD--WRLFSAFKNRLS--FVLDD-VIW------Y-----------------PL--------NLAEGK------VGD----KELGDLMSKIDEER-----------
>RLE99120.1 reverse gyrase, partial [Thermoprotei archaeon]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IGSRAE-LLRNVVDAYS----LVEEGS----------------V-EERVA------------EIVKALG-R---GGLIFLQPGVGEDY-------VKKLLALLEEK-GIKAALVTSR---S---KEALEAFERGELDVLVGYAIYYGLLVRGVDLPHVIRYAVFAGVPHFRFTA-------EV-SE-AGPLRLLQLAQVLRSV-I-TGD------EGSAL-DRLTAKLR-RQV--ANLEAA---AFQRLS-E--------ALV-EGV-----KPE-GY----LGYLYE-LFEELRGRLKDLLSRREVLEALEAR-TLA---SIR-FV-------NGK--PYL-LLPDAPTYLQASGRTSRMYAGGISRGLAVVVT--DD--EKLLSALMKQVS--WYVDE-VSW------T-----------------KY------------EE------L-------DLREILKEIDEDRRKIRDL-WE-G
>RLG86867.1 reverse gyrase [Thermoprotei archaeon]
-------------------------------MGNPRSVVEV----------------------------SDER--P-------------------------------------------------------------------------------------IARGIYRGLCMNCGGEVED-LRLLYGLPCSRC-LPE---KE---------------------LRSYGSFRE----LASRVKNVRKG-------S----VLE-KMV--SIESFVSELEDLFRRCV-GSNFWSIQRMWAYRLAQKQSFAMIAPTGVGKTTFGLVAALYY-AM-K--------G-R----KTYIVVPTTVLVTQY---EQRIY-EF----SEK-------A-GF---VPM-------------VVAIH-SKI--PGKRRK-ELEEQLKN-GLF-D------IAITTTMYLQRKFSE-VLR-------SVRVDLVFVDDVDAIMKG-SRAVEYVLQLIGFTP--SDIDLG-------YKSMKLRT---LIA-----------AAEH------NRD---R----YLKE-------F-----------EEVQRALRKRRE------S-AG-VL--ILSSAT--GRARGR-RVKLFRELLGFDVGTRAE-VYRNVVDTYV----EPSDKR-------------S-AY--EILI------------DIVRRLG-R---GGLVYVPVDKGIEE-------AEKVAELLRSH-GVRADTLISG---R---GGGLEKFVSGELDVLVGVAVFYGLLVRGIDLPEHVRYAVFLGVPRHKISL-------RL-EE-PSPQNMLRLSTVLSEV-V-DEG------TRREI-ARYLPVLR-RIL--RRYSQQ---AISEMV-K--------RLA-SGE-----APR-SR---EE----E-ALLKLYNLLGEVLSRREVVEALKAY-PRA---AVV-EE-------EGR--LYL-LIPDAATYIQASGRTSRLFAGGITRGLSVVIV--DD--ARLLRGLEYRLR--WYIED-FEF------K-----------------RL------------DD------V-------DLQEVLKQIDEDRELVRAI-RE-G
>WP_109160079.1 reverse gyrase [Desulfurococcaceae archaeon AG1]
------------------------------------------------------------------------------------------------------------------------------------------------------------------MLAVYEALCPSCGGDIDS-HRLSMGLPCRSC-LGI-ISPGLDII-----------------EDPFERARA----I---LSITGRG-------G----DYG-SII--SQEEDLKAFSSFFERVV-GHSMWSIQRAWARRLLKGSSLVLTAPTGSGKSTLVQAYSLYM-AS---------KG-Y----SVYLVVPTRELLRQS---VDRIS-SM----ASR-------S-SA---R-------------VRIAYYD-SSA--KKDLRE-KALDVIRA-GEY-D------LLATTSSMFTKISGI-L-SE--RR-----FDIVVADDLDSLIKS-SRNLEGILSLVGVSR--EEIELA-------LKIASKKY---EIAL-ARASKDPG-------------E-LEK----SREE-------I-----------EVLKAELALSLSR----KR-LG-QL--VVSTAT--GKSWGL-RSKILREILGFEVGGILE-YMRNIIDAYT----QPGGDD------------------IDSLE------------DLLKTLG-S---GTIIYFSRGYDDEK-------ISEIINNLSQR-NLRIGIYKPG-------GRSLRKFLEGELDFIAGKASFYGSLVRGLDEPLRIRNAVFIGIPKHVIPLKS-----YL----ADLRNLALFYKSTD-----S--------------QDTYREIY-RLL--RRLPPT---LPPVIK---------KILK-GYA-----EAG-ESLRETIDLIKG-WISSAIPIARQRCR-----DGIELG-G-S---LIM-CP------GNSE--PVA-VIPDAMTYIQASGRTSRLFSGGMTLGLSIVIP--ES--LELLSLLYKRLK--RYIPE-LVF------R-----------------EY------------RE------L-------DLKGIRREQERSRN----P-GS-M
>WP_069281717.1 reverse gyrase [Sulfolobus sp. A20]
--------------------------------------------------------------------------MIN---------------------------------------------------------------------------------------IKYLNACPNCGNEISS-SRLIKGLPCDNC-LQ--DVNHIDIQ------------------DQLTKIKT----IYEILINNGKI-------I----NYW-SLY--YNVSLYEKVFEYFRRKT-GYQPWSLQKLWLKRLVDNQSFTLSAPTGLGKTTTLMVYSTYL-N-------------E----DVVYIVPTKSLVDQV---CERLR-KL----GGE-------V-SC-------------------------GKV------------------ED--HK-----LNVITVSYLNKNSDT-I-T-V-------KPKLVIIDDADAVVKS-GKTTDRLVSLLGVPR--EVYNSA-------IQLTRLKQ---KFLL--------------------NSD-NDE----IKER-------I-----------RDLELKIASFNEK-------IS-QL--VVASAT--IRPKGI-KQKALRLLTGFEPASVQL-YARNIIDSYE----------------------------ENLDL------------SIIQKLG-S---GGLILVSKELGRDM-------MKKIKDEIQEF-GLETKLAISG-------RRFLDEFSSGKVDVLIGSASYYGVAVRGIDEPKKLKYVVFYGVPKTRIKLYN-----AI----SNPF----TLLRVAKV-L----------------GLDVSRIQNDVLF---LNYS---EAQLIR---------YSIL-NNE-----DIN-NE---KLQRIKS-NLLEYISLIKDKLKDINSSTIISDN---F---VIS-YE-------NSS--YYM-TYPDVITYLQGSGRSSRLYNGGLTLGLSIVLI--DN--KLIFEILKRRLQ--RMLPE-IAF------K-----------------EL------------SE------L-------NLDMVKQQLDSSRRD---------
>WP_123352073.1 reverse gyrase [Cetia pacifica]
--------------------------------------------------------------------------MLE---------------------------------------------------------------------------------------SIYKNRCPRCHGDITS-NRLQNGEFCDKC-MSE-----------------------------IK-SFE----NC------ENL-------M----FYE-KFC--KAKEKLEEFNDFFHSKT-GNDLSDIQKMWAKRYFLDNSFALLAPTGIGKTTFGLLLSAFE-KN------------------SYIIFPTKLLVLQA---LERFK---------S-------W-GI---DV---------------LAYT-GK--------K-QEKEKIKS-GEY-D------ILITTTQFLYKNREI-I-N---K-----DFKLVFVDDVDSILKS-AKKIDDVLSLVGFSK--EDIDEA-------LRLIEKKE---Y-------------------------------------------------------------EKLQE-FQ--KK-KK--G-NL--IVSSAT--ANPKSK-RVLLFKYLLGFEISRPNL-SLRNVIDSYD----V-------------------EYS-WQKSV------------EWIRRLG-R---GGLLFLPGNESKEK-------VYEYIEFLKKN-SIKAYSYEEF--E-----EKIEEFKKGEC-FFVGFASYKNPLARGIDLPEFIRYTLFVGVPKMEFRL-------S--E--DNYRSLYFILLSVYPY-L-LKNNILNEDEKIEF-QKAIEFMK-KYV---------------------------FFS---V-----LHP-------NV--EK-KLSEISQKIKKFIKKYE--NEIKNS-PEI---SFD-SE-------------KL-IVADITGYIQASGRSSRFYKGHLTKGLALTLV--DN--QKAFYSLKKRLS--WFVK--NEF------V-----------------DI------------NT------L-------DLDEILKEIDESRK----------
>WP_126449916.1 reverse gyrase [Sulfodiicoccus acidiphilus]
--------------------------------------------------------------------------MIT---------------------------------------------------------------------------------------AVYSGGCPNCGGPIEF-QVAASGLPCKAC-ADI-PAAAVAGL------------------SREDVIRA----VYSVLVDNGKL-------S----AYW-ELY--DRLQRFEEARRFFEEKV-GYSPWNLQLFWLRRLVAGDSFSMSAPTGLGKTTTLITYASLL-SQ-R--------G-K----RTVYIVPTKSLMQQV---CDKIK-EM----SVR-------L-GC-------------------------GVP------------------RF--EG-----IDVITYQYLNRRAEG-G-MGV-------VYDFVAVDDADAIIKS-GKTVDKIVPLLGIPE--QVYKDT-------IRLVKLRN---ALRF--------------------YITVDQEKAEKLAKD-------V-----------EEIERRVVESRSS-------YS-QF--VIASAT--AKPKGI-KQKAMKFLLGFEPSTVQI-YMRNVLDSYT----------------------------QLDPT------------EIVTKMG-K---GGLILVSRDRGKAG-------ILELKERLESK-GIKVGLALNG-------RRFLKDIVEGKVDVLLGSANYYGVAVRGIDEPRAIRYVVFHGVPKVKLSLKA-----AL----FNPF----IVSSLASL-L----------------DLEARELQTTLSS---LNPS---EAQMLK---------VAMW-RGE-----QLT-G----KLKEAKR-ALEEMGELVREALKRR--RKVIGKY---F---VVA-GE-------SEK---YV-VFPDVVTYIQGSGRASRMINGKLSFGLSVTVV--DD--QEVYELMKTRMG--NYMDK-FEP------V-----------------KF------------DD------L-------NLTEISRAIDTSRSGV--------
>WP_084274842.1 reverse gyrase [Nitratiruptor tergarcus]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------LIYKKMCPNCGGDICS-ERLFKGLVCKKC-LPK-E-------------------------------AN----PC------EAL-------E--EGDFL-QIC--NLQKEVSEFESFFEQRS-GFSPRELQLMWAKRLFLDISFALLAPTGVGKTTFGLISASFL-KT---------HG-K----KSYLIFPTALLAKQA---YERLA---------Q-------M-GE---DA---------------LLYD-SHASQKQK--E-AVKEKIQE-GDF-S------ILITTTSFLYKNYSI-I-P---Q-----VFDFVFVDDVDSILKS-AKNIDKVLYLLGFDE--SDIQKT-------LEFIDYKR---RL-------------VRQ------KNI--------DWEE-------F-----------ESKRKEIES-IA--RK-RK--A-TL--IVSSAT--ANPRSR-RVLLFRELLGFEVSRPSI-TLRNIEDIYE----E------------------SDEL-WKRSI------------ERIREFG-K---GGLLFLPSNATKEE-------LRKFLAFLEKE-GVKAQSYEEF---------DEEAFREGEIDVVVGFASYRNPLARGLDLPDVVRYALFVGVPKLEFKL-------DL----QKTSSLYFFLLALVPA-L-KSEPFFP-----QV-LKYIDYLK-RTA---------------------------FIP-AQR-----LTP-------QA--QE-KIQHIYDWLQELLNE-EFIQKINKS-PDV---SLV-KD-------DT---FKV-ITADVTGYIQASGRTSRLFVGGLTKGLSFVLV--DS--QKAFVSLQKKVR--WFSEE-IVF------K-----------------RA------------GE------V-------DIKEILYQIDEDRKKVRAA-LA-G
>PSN97558.1 reverse gyrase [Candidatus Marsarchaeota G2 archaeon ECH_B_SAG-C16]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MITS-SRLERGLPCEKC-LPE---------------------PVDPATRSIEEWHSL---VASQLDRQGTLN-----------RYR-EIV--NLEDRAKEFVNVFHSLT-SREPWSAQLTWAKRCLRGESFSIIAPTGVGKTTFLSVLAVYM-AR-M--------G-K----RVLMVSPTALLARQT---AGWVK-RY----SAV-------Y-DH-------------T---IKVAELH-GEE--TGKAKR-EALSMVDD-ASA-N------IVVVTAAGLGNLFER-L-LKI-------GFGLILVDDVDALLRK-SVNIDRVIRLLGFSE--EVQGIA-------TEAILLRI---RLA---RLFAQG--------EVR-TEE-VDS----LLSR-------Y-----------KTLRKQIDEYKN--TH-SN-LG-QL--IVSSAT--ARPRGL-KVKVFRELFGFDAGSSAT-YLRNIVDV--------EAKL-------------DDDV-LGQVV------------SLVKRLG-R---GGLIFVAKDYGRET-------AKKIEEALNQA-GVKASQTSSYF------HKRVDEFASMKIDVLVGPASYYGKLVRGIDLPQSVRYTVFVGVPKFSSRLED--------EE-LSPLGIIRLLYAMSEL-IRDPI------ERQKT-FQQAVKLR-KMV--QNLSPS---DLRMVE-LA--------IK-ENR-----QLT-GY----LGQVQE-EIGVGRMIFHNQLATPNMLHELTQS-DRL---IIQ-ET-------PEG--PLV-LAPDVKTYIQASGRSSRLFGGKLAKGLSIVLV--DN--PRVMSALQRSMQ--IASSN-TKWY-----------------------KL------------GE------L-------DLDEVLREIDEDRRFNAKAKSE--
>RLG87390.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------------MR----------------------------------PRAYQLIH-----------IAIKRCVNGSW--------------------VMIPVIYRHGCPYCGGEIEA-ERILKGLPCRRC--------------------------------------E----EASAAAH----------------TFM-R----AYAKELEELEEFFTKAT-GFKPWSLQRAWMKRLLSGESFAMVAPTGVGKSTLLAVYVLYR-AL-N-------YG-W----RVYVLAPTREIALQF---SRRLG-EF----YDK-------L--R---RYY-------GKE-LRIVVYV-SGT---SRSS--AVKERISR-GDF-D------VLVTSAGFLVRNFGM-L-QK--MG-----FQLIVADDLDAVLRN-SKNVDRILMLLGFTE--EEIRLA-------YELVKAKQ---ELVV-SMLAGRE-------------ER-ARE----LEAV-------I-----------EELRARLKMISVE-----K-KR-QL--VVASAT--GRSGGV-KSKVLRELLGFEGGAVFE-YWRRVVDTYI----HMDEGGEW----------------LEHVV------------SVIKLLG-S----GIVFVARGYEP----------KAVVSKLLSK-GVRAELVRSG-------SKAFDKFRRGEVDVLVGSASYYGILVRGIDEPLRVRFTIFIGVPRSGVRLEN-----AL----NSVRFLYVLLEYLS-----RRG------IT--S-SGYVDFVV-GIL--KKSSLA---YLNLLR---------KALAQGCR-----DCD-EKLSEVVAKLLE-IKSWVRERVGEIVASE---GKIVLP-T-A---VIT-RK------GRDI---YV-YRPDPYTYIQASGRSSRLLKGRKTVGFSLIVA--DD--HDLLVLLEKRLK--NLVPE-LEF------R-----------------RL------------EE------V-------DLNEVAAQVARSR---EEG-SE-E
>WP_007473084.1 reverse gyrase [Caminibacter mediatlanticus]
--------------------------------------------------------------------------MLE---------------------------------------------------------------------------------------AIYKNRCVRCLGDITS-LRLSRGEFCDKC-MQE-----------------------------IE-NLE----NC------NEL-------L----NFK-KFC--EANKKLEEFNNFFKEKT-GSTLNSIQKMWAKRYFLDNSFSLLAPTGIGKTTFGLLLSAFV-NN------------------SYIIFPTKLLVSQA---IERFK---------L-------W-GI---EV---------------LAYT-GK--------K-NEKEKIKN-GEY-N------ILITTTQFLYKNKKL-I-N---K-----NFDLVFVDDVDSILKS-GKKIDDILGLLGFNE--EDLQKA-------MELINKKE---Y-------------------------------------------------------------EKISE-IA--KK-KR--G-NL--IVSSAT--ANPKSK-RILLFKYLLGFEVSRPNL-TLRNIEDLFD----E-------------------KFS-WELSI------------EWIKKLG-I---GGLLFLPGNETKEK-------LYEYLEFLNNK-GIKAYSYEEF--N-----DHIDEFKKGEC-YFVGFASYRNPLARGIDLPQAIRYTLFVGVPKMEFNL-------N--E--DNFRSLYLILLSVFPY-L-MKNNLLDKKEAIEF-QNYINFMK-KYV---------------------------FYT---I-----LHP-------KI--EE-KLRLISTKIKILIKKYE--NEIKNS-PEI---SFD-GE-------------KI-ITADITGYIQASGRSSRFFNGHLTKGLSLVLV--DN--KKAFFSLQKKLK--WFSE--AQF------K-----------------RV------------DE------V-------NLEEILEEVEESRK----------
>PSN86466.1 reverse gyrase [Candidatus Marsarchaeota G1 archaeon BE_D]
--------------------------------------------------------------------------MEL---------------------------------------------------------------------------------------AQFLSACPNCNGKIDD-FRLQQGLPCKEC-LPK---------------------IPD-FQKNHPDFRKM---VAKELEKRGRLL-----------GYA-QLV--ELDSQTQEFISIFQKLT-GSKPWSAQITWARRSMRGESFAIIAPTGVGKTTFLSVLATYF-AM-K--------N-K----RVLMIAPTALLARQI---ARWVK-NN----CEK-------M-NV-------------T---LNVAEIH-GEE--TESSKK-ASLKMVEE-GSA-N------IVVLTSMGLSRIFAK-I-SKL-------EFDVALVDDVDSLLRR-SVNIERVLNLLGFSS--SVQEIA-------AQSVLARL---KLA---RAFRQG--------LAD-SDE-TKT----LLER-------Y-----------QTLKSEIEKYKL--SR-VK-LG-QL--IVSSAT--ARPRGL-KVKLFRELLGFEAGSSSD-YLRNIIDVCV----YLETRT-------------SESV-LKSAV------------EWVKKLG-K---GGLVFVSKEFGKSF-------MEKLVERLREV-GVKAYHTKGAF------RKRVDEFAKGDVDVLIGTASYYGKLVRGIDLPESVRYTVFVGVPKFKTSLQD--------EE-ASPTGLIRLLYATADF-ITNPL------ERQKL-FEQATKLR-KLI--QNLSPG---DLSLVT-KA--------IQ-EQT-----TLT-GY----LGKVQE-EVGEGRKLFHMMLAQPGVLKKLKES-DRL---IIE-EE-------ESG--FVV-LTPDVKTYIQASGRSSRLLGGKLTLGLSVVLV--DN--ERVMSALMRTMQ--IASSS-TKWYTPTQNK----------------RKL------------KEISTSESL-------TLEEVLKRIDADRTRKRTSPSE--
>GBD39415.1 Reverse gyrase [bacterium HR37]
--------------------------------------------------------------------------MEE-----------------------------------NLRNIPL---------------------------------------------IQYRGICVIDENEADT-EHILKWGFCKED-------------------------AAKFGKPFWDV-----------IRQVSCE----ELKKA---RYF-----CEIEKKISSFIKFFEENL-GIKHNSLLLYWAKRVLSGQSLSIHAPPGFGKTTFGVSISHFI------------DG------KVYYIVPTKVLCREI---GDKIR-SFK---SGK-----------------------------RVLVVD------DKVDKS-----EISR-FEY-D------ILVSTSHFLHKNFDV-I-PK--------DFNLIFIDDADSLVRQ-PKNIDKVLKLIGFSD--EDIAFA-------L---SKHA---Q-------------------------K-DRG----LLDK-------I-------------------------KK-KK-RG-QV--VVASAT--LSPKTK-RIYLFRELLDFEIAQSSTTFLRNVVDSYK----DVSKGD-------------KEHL-LREAL------------HFIKNLG-K---GAFVFLSSDFSRDE-------LKEFVSYLCEN-GIRAISYEQFT------RRNRDRFIEGEIEAVVGFSNIRNPLTRGIDLPQAVRYALFVGVPKYKVPL-------KT-S--YSPKRLFLLLFLLGEF-I-HNR------GAR-V-HDYLAFLR---------------RLRFVT-EE------MVLR-------------------DEKLKN-RVEPIKRELDVLLQDKAILDAIREK-TNL---DLK-EEDDPEVPGQKR--LVL-LISDPRGYLQASGRTSRLFSRGLTKGFSLILV--DN--EKVLKHLKEKLA--VMGYR-IEF------E-----------------DV------------RK------L-------NLKEVFQKIDEDRKIVSEL-VR-E
>RLG66351.1 reverse gyrase, partial [archaeon]
--------------------------------------------------------------------------MT--------------------------------------GKVSE----------------------------------------VNTIPAIFSGLCPNCGGDIDS-QRLQLGIPCEKC-LPN-LNIE-ELKS----------------KNRIERIEY----IARLLEKRNLL-------K----NYS-EIY--RLEKLYNEFEEFFKFLI-GNKMWSAQRSWARRIFLGRNFSIIAPTGMGKTSFGAVMSLFL-AL-R--------G-K----KCYIMLPTSILVRQV---ADKIQ-SM----IEK-------G-GY--N-IR-------------LVYYH-SLL--TPKQKR-EMKARIMN-EDY-D------ILITTSFFLAIKFEE-FLKG--R-----FFDFIFVDDVDAFVKT-SKNVDKVLMLLGFTE--EIIDAG-------MRAAKLVT---RAF----FDKSA------------YEE-LRK----LREE-------I-----------AEFKSSHRV------------G-ML--VVSGAS--ARAKRTLRVKLFKELLNFEVGRRVE-GERNVVDAYL----FPEK-----------------SI-EEHVV------------DLVKRLG-K---GGLVFAPMDKGSEY-------VTTLAKTLKEH-GIKAEAYTSA---R---KKLLDQFVNGEIEVLVGVASYRSPLARGLDLPETVRYAVFAGIPKFKISL-------DL-RERFHTFKLFILLANIVEL-L-EGE------ELDEW-SRKLSWLR-TTLS-RLTSEQ---EL-ILN-R--------AIV-ENE-----QLT-GR----LEHIRQ-RILEIRDQLQKLLEREDIKEKIKTS-PRL---TLE-EN-------A-----YL-ITADAVAYLQASGRTSRMFIGGMTKGLSVLIV--DN--EKAFRGLLSRLK--W-LED-IQF------V-----------------DF------------RE------V-------NIESLLEEIDRDRKLIADL-RR-G
>WP_014454078.1 reverse gyrase [Caldisericum exile]
------------------------------------------------------------------------METIS---------------------------------------------------------------------------------------TIYKNLCPNCGNDITD-DRLKLGLTCEAC-LDR-I---------------------------VP-KEQ----IC------NYL-------K--IEQFK-SFC--NLREHLSKFKNTFKNTT-GFNLSSLQEMWAIRFFLDNSFALIAETGIGKTTFGLTLSKYI-SE-N-------NI-G----FVYLIFPTNILVKQA---KEKLL---------K-------F-GI---AEN------------EIIAYD-SNLPKNTL--E-LLKYRIQE-GDF-K------ILITTTNFLYKNFDM-V-P---KG----LYSLVFIDDVDSILKN-SKNIDKVLKLLNFND--EDIEKA-------LKLIDLKR---LS-------------LKN------KV---------DQET-------L-----------QSVIEDVNK-IK--AK-RK--G-VL--IVSSAT--TNPKSK-KVLLFRELLNFEVGRVVS-TLRKVVDTYK----IV-----------------EGDL-FSEAL------------SEIKKLG-K---GGLIFLNTDYTKED-------LENFVHFLNKN-GVKALSYEHL--T-----KVLEDFKQGSLDVLVGFSTYRNPLARGIDLPSVIRYALFVGVPKIKFSL-------SA-T--EGNRGLYYAILMLAPH-I-TRKKILKDSEVAKI-YRYLNILK-RYS---------------------------NVI-EES-----GDN-------PY--QK-AYAEAVNYFKELFKREDIVKIIEET-PDI---ALQ-RK-------GNE--LSF-VVVDTTGYIQASGRTSRLIATGLTKGLSLILT--ND--LKALLVLGKKLK--WFIED-ALL------L-----------------PY------------ET------V-------NIESILKEIDDDRALVRKI-ES-G
>PSN83562.1 reverse gyrase [Candidatus Marsarchaeota G1 archaeon OSP_D]
--------------------------------------------------------------------------MEL---------------------------------------------------------------------------------------AQFLSACPNCNGKIDD-FRLQQGLPCKEC-LPK---------------------IPD-FQKNHPDFRKM---VAKELEKRGRLL-----------GYA-QLV--ELDSQTQEFISIFQKLT-GSKPWSAQITWARRSMRGESFAIIAPTGVGKTTFLSVLATYF-AM-K--------N-K----RVLMIAPTALLARQI---ARWVK-NN----CEK-------M-NV-------------T---LNVAEIH-GEE--TESSKK-ASLKMVEE-GSA-N------IVVLTSMGLSRIFAK-I-SKL-------EFDVALVDDVDSLLRR-SVNIERVLNLLGFSS--SVQEIA-------AQSVLARL---KLA---RAFRQG--------LAD-SDE-TKT----LLER-------Y-----------QTLKSEIEKYKL--SR-VK-LG-QL--IVSSAT--ARPRGL-KVKLFRELLGFEAGSSSD-YLRNIIDVCV----YLETRT-------------SESV-LKSAV------------EWVKKLG-K---GGLVFVSKEFGKSF-------MEKLVERLREV-GVKAYHTKGAF------RKRVDEFAKGDVDVLIGTASYYGKLVRGIDLPESVRYTVFVGVPKFKTSLQD--------EE-ASPTGLIRLLYATADF-ITNPL------ERQKL-FEQATKLR-KLI--QNLSPG---DLSLVT-KA--------IQ-EQT-----TLT-GY----LGKVQE-EVGEGRKLFHMMLAQPGVLKKLKES-DRL---IIE-EE-------ESG--FVV-LTPDVKAYIQASGRSSRLLGGKLTLGLSVVLV--DN--ERVMSALMRTMQ--IASSS-TKWYTPTQNK----------------RKL------------KEISTSESL-------TLEEVLKRIDADRTRKRTSPSE--
>PSO00295.1 reverse gyrase [Candidatus Marsarchaeota G2 archaeon ECH_B_3]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MITS-SRLERGLPCEKC-LPE---------------------PVDPATRSIEEWHSL---VASQLDRQGTLN-----------RYR-EIV--NLEDRAKEFVNVFHSLT-SREPWSAQLTWAKRCLRGESFSIIAPTGVGKTTFLSVLAVYM-AR-M--------G-K----RXLMVSPTALLARQT---AGWVK-RY----SAV-------Y-DH-------------T---IKVAELH-GEE--TGKAKR-EALSMVDD-ASA-N------IVVVTAAGLGNLFER-L-LKI-------GFGLILVDDVDALLRK-SVNIDRVIRLLGFSE--EVQGIA-------TEAILLRI---RLA---RLFAQG--------EVR-TEE-VDS----LLSR-------Y-----------KTLRKQIDEYKN--TH-SN-LG-QL--IVSSAT--ARPRGL-KVKVFRELFGFDAGSSAT-YLRNIVDV--------EAKL-------------DDDV-LGQVV------------SLVKRLG-R---GGLIFVAKDYGRET-------AKKIEEALNQA-GVKASQTSSYF------HKRVDEFASMKIDVLVGPASYYGKLVRGIDLPQSVRYTVFVGVPKFSSRLED--------EE-LSPLGIIRLLYAMSEL-IRDPI------ERQKT-FQQAVKLR-KMV--QNLSPS---DLRMVE-LA--------IK-ENR-----QLT-GY----LGQVQE-EIGVGRMIFHNQLATPNMLHELTQS-DRL---IIQ-ET-------PEG--PLV-LAPDVKTYIQASGRSSRLFGGKLAKGLSIVLV--DN--PRVMSALQRSMQ--IASSN-TKWY-----------------------KL------------EE------L-------DLDEVLREIDEDRRFNAKAKSE--
>PSN95725.1 reverse gyrase [Candidatus Marsarchaeota G2 archaeon ECH_B_2]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MITS-SRLERGLPCEKC-LPE---------------------PVDPATRSIEEWHSL---VASQLDRQGTLN-----------RYR-EIV--NLEDRAKEFVNVFHSLT-SREPWSAQLTWAKRCLRGESFSIIAPTGVGKTTFLSVLAVYM-AR-M--------G-K----RVLMVSPTALLARQT---AGWVK-RY----SAV-------Y-DH-------------T---IKVAELH-GEE--TGKAKR-EALSMVDD-ASA-N------IVVVTAAGLGNLFER-L-LKI-------GFGLILVDDVDALLRK-SVNIDRVIRLLGFSE--EVQGIA-------TEAILLRI---RLA---RLFAQG--------EVR-TEE-VDS----LLSR-------Y-----------KTLRKQIDEYKN--TH-SN-LG-QL--IVSSAT--ARPRGL-KVKVFRELFGFDAGSSAT-YLRNIVDV--------EAKL-------------DDDV-LGQVV------------SLVKRLG-R---GGLIFVAKDYGRET-------AKKIEEALNQA-GVKASQTSSYF------HKRVDEFASMKIDVLVGPASYYGKLVRGIDLPQSVRYTVFVGVPKFSSRLED--------EE-LSPLGIIRLLYAMSEL-IRDPI------ERQKT-FQQAVKLR-KMV--QNLSPS---DLRMVE-LA--------IK-ENR-----QLT-GY----LGQVQE-EIGVGRMIFHNQLATPNMLHELTQS-DRL---IIQ-ET-------PEG--PLV-LAPDVKTYIQASGRSSRLFGGKLAKGLSIVLV--DN--PRVMSALQRSMQ--IASSN-TKWY-----------------------KL------------EE------L-------DLDEVLREIDEDRRFNAKAKSE--
>RLE51998.1 reverse gyrase, partial [Candidatus Verstraetearchaeota archaeon]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VRKIADMYT----KAS--N----------------V-VDQVV------------ELVKELG-G---GGLIYVPMDKGAAY-------VKKVAEALEAS-GIKVTTYERT---K---GKILEKYRKGEYEVLVGIASYRSPLARGIDLPERVRYAIFAGVPKIKISL-------DI-EE-FRPSRAIILLANLRDF-VETQK------EADMI-DKYIADLR-RFS--GMLRRD---EVERIV-E--------SIK-AGE-----KLE-GF----IGRVQE-LFIETANFLRELLSRENIRRKIKES-PYL---SI--EG-------EDK--PVI-VVPDVVGFLQASGRTSRMYAGGVSKGLAIVIV--DS--EKAFNGLVRELK--WYIED-VKF------I-----------------EL------------SR------E-------KLREVIREVDKDRETIRKL-RE-G
>PSN97630.1 reverse gyrase [Candidatus Marsarchaeota G2 archaeon ECH_B_SAG-F08]
--------------------------------------------------------------------------MEL---------------------------------------------------------------------------------------AQFLSACPNCNGKIDD-FRLQQGLPCKEC-LPK---------------------IPD-FQKNHPDFRKM---VAKELEKRGRLL-----------GYA-QLV--ELDSQTQEFISIFQKLT-GSKPWSAQITWARRSMRGESFAIIAPTGVGKTTFLSVLATYF-AM-K--------N-K----RVLMIAPTALLARQI---ARWVK-NN----CEK-------M-NV-------------T---LNVAEIH-GEE--TESSKK-ASLKMVEE-GSA-N------IVVLTSMGLSRIFAK-I-SKL-------EFDVALVDDVDSLLRR-SVNIERVLNLLGFSS--SVQEIA-------AQSVLARL---KLA---RAFRQG--------LAD-SDE-TKT----LLER-------Y-----------QTLKSEIEKYKL--SR-VK-LG-QL--IVSSAT--ARPRGL-KVKLFRELLGFEAGSSSD-YLRNIIDVCV----YLETRT-------------SESV-LKSAV------------EWVKKLG-K---GGLVFVSKEFGKSF-------MEKLVERLREV-GVKAYHTKGAF------RKRVDEFAKGDVDVLIGTASYYGKLVRGIDLPESVRYTVFVGVPKFKTSLQD--------EE-ASPTGLIRLLYATADF-ITNPL------ERQKL-FEQATKLR-KLI--QNLSPG---DLSLVT-KA--------IQ-EQT-----TLT-GY----LGKVQE-EVGEGRKLFHMMLAQPGVLKKLKES-DRL---IIE-EE-------ESG--FVV-LTPDVKAYIQASGRSSRLLGGKLTLGLSVVLV--DN--ERVMSALMRTMQ--IASSS-TKWYTPTQNK----------------RKL------------KEISTSESL-------TLDEVLKRIDADRTKKRTSPSE--
>WP_110369451.1 reverse gyrase [Metallosphaera hakonensis]
--------------------------------------------------------------------------MIS---------------------------------------------------------------------------------------SVFHGSCPNCQGPLED-YRALAGLPCTEC-FPG-NSDAFRDM------------------PQVEKIKV----VYNLLVNSGKL-------A----KYW-ELY--YTSEMYNELIDYFKRVT-GNEPWSLQRLWLRRLGERENFSLSAPTGMGKTTTLISYSTYL-S-------------K----GVLYIVPTKSLQEQI---CSKIG-AI----SS--------V-AC-------------------------GKV------------------DP--EG-----ISVLTVSYVNKNYHL-M-QNY-------RPNFIAVDDADAIIKS-GKTTDKLVEIMGIPK--EVYEDA-------MRLVRLRR---LLYL--------------------KEE-KDD----ILEK-------I-----------ASLERKIQSFSGI-------IA-QL--VVASAT--LRPKGV-KQKALRYISGFDISTAQT-YARNIVDSFT----------------------------TSSLV------------EIVQRLG-A---GGLILVSREYGKEK-------MKQIREELQSL-NLRVELATSG-------RKFLQDFSAGNTDILVGSASYYGVAVRGIDEPKRLRYVLFYGVPKSRARAED-----AV----KNPF----TLLKVSRL-L----------------GMKVP--EDEILG---LSPA---EAQAIK---------IAMI-TGQ-----PLQ-G----KLGDLLE-KMKDLVTQVQESLRKI-DGTIKGET---F---LLS-RK-------GKD--VFI-EYPDIITYLQGSGRSSRLLNGGLTKGLSVVLV--DD--PVIFELFKRKMN--FLIPG-FSP------V-----------------SF------------EA------V-------NLDEVKNEIERTRRE---------
>WP_010979311.1 reverse gyrase [Sulfurisphaera tokodaii]
--------------------------------------------------------------------------MLK---------------------------------------------------------------------------------------VYYTFGCPNCGGPIDD-EHLLAGVPCSKC-LPG-RVENLD-------------------------YRV----IYDLLVKNSTL-------K----GYA-EYF--YDNETFEEIVRIFKRVI-GNEPWNLQKYWIKRLAKSESFSLSAPTGLGKTTTLLVYSLFF-S-------------N----TTLYVVPTNSLKDQI---CERLR-NM----GAK-------V-SC-------------------------NDV------------------KE--EY-----INVATFNRILRHYDN-Y-VSL-------QPKLVIVDDSDMILKS-GKTTEVMAKILGISE--EIFQYA-------ISLIRLKR---ILKF--------------------NED-DKE----LKNK-------I-----------VELEYKI-GSWKP-------FV-QF--LVASAT--LRPKGI-KQQALRTLIGFEPSTIQT-YLRNIADLYY----------------------------QGVDI-----------EAILDKIS-DN--GGLLLVSKEYGREK-------MLELKEIIEKR-GYSTGLAISG-------RKFLNKFTEGKIDYLIGSASYYGVAVRGLDEPKRLKYVIFYGIPKIRLNLTD-----AL----NNPS----LIVKIGEL-L----------------NIDVKDIRRKLLF---LSPP---EFQILR---------YSLM-KDE-----ELS-G----KLKDIKV-NLINIKEKIWDVLKSDNIKKLKADT---F---LVT-EN-------NGK--YYV-YIPDTVTYIQASGRSSRIISNGLTFGISIVLV--DN--IDLLDILSQKLK--KIIPN-FMF------K-----------------NI------------NE------V-------DIRELKSLAVSSREV---------
>RLG81017.1 reverse gyrase, partial [Thermoprotei archaeon]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KHS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ER-------A-NI---ND-------------MIIVFH-SRI--SRKVRE-DYLQRISN-GDF-D------ILLTTSMFIHKYTEL-L-KK--Y-----KYSFIMVDDVDAILRS-GKSIRLLLQIIGFTE--EEIDAA-------LQLIKLRI---SLA----------------RTTD-EER-RKE----IEKE-------V-----------KKLEAIVEKARSRIKT-------IL--VVSSAT--GKPRGL-YPRLFRELLGFEAGSRSE-AIRNIVDTYT----ISKE-----------------NV-ENYLL------------KLIRKLG-G---GGLVYVPIDKGVEY-------AEYIANLLKEN-GVKAEAFHSK--KN---IRVLEYFAKGELDVLVGVATYYGVMVRGLDLPERVRYAIFIGVPRHKFSS-------KL-ES-PRPFDIVRILSILRDV-V-SGD------ERRKI-EVIIGRLT-QRL--RRLSPA---ALAIIG-E--------ELR-KAV-----TGE-EY---KESPVLQ-LLLEALEYTRKLLERPDVWEKLKES-SDV---ALV-EE-------DGR--TYI-LIPDVATYIQASGRTSRLYPGGITKGLSVILV--DD--RRLLNGLARRMR--WLFED-FEF------K-----------------DL------------NE------I-------DLDKLLEEIDNDRERVRKI-IS-G
>RLE71341.1 reverse gyrase, partial [Thermoprotei archaeon]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV------------KLIKTLG-K---GGLVFVPVSKGLEY-------AQALNEKLRQA-GIRSEVVHAK---E---KSALDRFVSGEVDVLVGVAVYYGLLVRGLDLPHIVKYAVFAGVPHFKFSL-------NL-EE-AGPFRLLQFAFNIRPA-L-EGY------EQSQL-DRLVGKIR-RVI--YDLDAA---SVQILT-E--------ALK-EGK-----ELE-GR----LEYVRK-NLVELKHLLIQELSKKDVVKRLEEK-TML---VIR-TE-------EGQ--QYI-YVPDTMTYLQASGRTSRLYAGGLSKGLSVVVV--DD--EGLFNKLVRQSR--WYSDE-IEW------V-----------------NF------------ND------L-------DVEKLMKEINKEREFIAKL-IR-G
>RLI08669.1 reverse gyrase, partial [Candidatus Bathyarchaeota archaeon]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DELAAFLRSK-GVRAEAFTRA---R---RKTVDAYVAGELDVLVGVASFRSPLARGIDLPARIRYAVFAGVPKMRISL-------AL-SE-FRPHRAIILLANLRDL-L-AGG------EADRA-DAYVVRLR-RIS--SLLRRD---ELKEVV-Q--------ALA-EGR-----SLS-GF----LEKARS-FFEEVWSFLKGLLARPDVREAIRAS-PHL---SMD-EE-------AGE--PYL-IVPDPVGYLQASGRTSRLYAGGISKGLSILVV--DD--EKAFNGLKRSLR--WYLEE-VEW------R-----------------PA------------DE------V-------DLGAIMAEVDRDRELIRKL-MA-G
>RLG80617.1 reverse gyrase, partial [Thermoprotei archaeon]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------AVFRGLCPG-GAELRT-HERS------PC-I-E-E-------------------------------------------------------E--------LVE---VGKEFNRYVEFFESCL-GSPPWEVQRMWARRVLSRRSFAAIAPTGVGKTVFGLITSYYF-AA-R--------GWG----PSYLIFPTSMLVDQA---VGNLR-RY----EGS-------V-GE---P-------------VRILHYR-SGM--GSAARR-EFLERLSS-GEF-D------ILVTTSQYLAKNHAS-I-RRGVD-----KFSFVFVDDVDSFLRN-SKNVDRVLTLMGFRE--EDVRNA-------L----------------------------------SGE---E----SWGS------------------------------------TD--S-VL--VVSTAT--GR-PGP-RVSLFRRLLGFDVGILRRELLRNVADIYT----RDE----------------------ESLK------------RFMRGMG-D---GFFLFVPK---MEL-------AEEARRIVESL-GYRAAVMRGY--D----EEAVEAFRTGELDALIGAARPYGVLVRGVDLPQRVRYVVFYGVPRFEMGLR------DL-DD-MSDRGVAAIFSVIARG-LDPEAR----------------RLA-ARLR----------R------GA--------------------------------TPW-DLERARSILREVLSDRERMSQLSS--GDI---TV--LP-------EEG---KI-VIPDIRTYIQGSGRSSRLYPGGMTKGASLVWD--RD---RLLNAFLKRAS--AY--D-LEF------A-----------------PL------------EE------V-------DLDTLRREVDESRRSYGSL-KT--
>RKY93329.1 reverse gyrase, partial [Candidatus Hydrothermae bacterium]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKSEKE-KTLQRIRD-GDF-S------ILVTTAQFLARNFEM-L-EG--K-----VFDFIFVDDVDSILKA-SGNVDRILHLLGFQR----------------------------------------------------Q-KGK----WLRE------------------------------------GK-HG-IL--IVSTAT--AK-KGR-KAQLLRELLGIDVGSSRF-LLRNVEDIYL----PERN--------------------LERLS------------SILKSMG-T---GGLIFAPS---EEE-------SETIRNELGAE--YRIGLATSR--S----RKDFERFKEGELDILVGTSHYYGVLVRGLDLPERIRYAVFYGAPSIRIALR------DL-E-----NLPDGMLKLLFFA-LRADPI-----------------LR-EVVN----------PL-----------------------------------------K-EREKVLKRIAEIMENPEGQA------EDF---VL------------RK--GEI-LFPDLRTYLQASGRTSRLTVWGLTKGASFLLE--ED--RMLLNAFIKRAS--YY--D-VDF------R-----------------PF------------HD------V-------NLVGLRMELEESRKK-----IK--
>WP_054845557.1 reverse gyrase [Sulfolobus sp. JCM 16833]
--------------------------------------------------------------------------MLK---------------------------------------------------------------------------------------VVYTAACPNCNGNLEA-ERALLSMPCSKC-LKE-EGIGLSSV------------------PHSERVKT----IYNLLVSSNSL-------K----NYW-NIY--YKIENYEEIINYFKKIV-KSDPWSLQKLWLRRLIDGENFTMSAPTGLGKSTTISLYSAYL-G-------------K----NVVYIVPTKSLVDQT---CKKIR-EF----GGD-------V-SC-------------------------GTL------------------DE--SK-----ISVITTNYLSKHKDE-L-GGI-------KADLVAVDDADAIIKS-GKTTDFLVRLLGIPE--LAYENA-------LKLVRLRK---YLVN--------------------VSGTPDEE--FLKKR-------I-----------RELETSLISFRGV-------YS-QL--VVSSAT--LRPKGI-KQQAVKFLTGFEPSSVQM-YSRNIIDA-K----------------------------GDLDI------------SLVRKLG-T---GGLVLVSRDYGKKM-------ISELKERIEEY-GLRADVAVSG-------RKFMEKLSRGETDVIIGSASYYGVAVRGIDEPTKIKYVLFYGVPKIKISLEN-----AL----LNPF----TLLKVMKA-V----------------GINDHEFERKVMS---ISVS---EAQAIK---------ISLL-KKQ-----EVQ-GD---KLKTLVD-AILKYKDEVVSKLRSSASSKIVTSG---L---VIV-SE-------KKG--FFI-EFPDVTTYLQGSGRSSRLYNGGLTLGLSVVLS--DD--NDLLDILEKRLK--SMVGE-FRF------Q-----------------EV------------SS------L-------NMEETIAKLDSCRRP---------
>RLE73958.1 reverse gyrase, partial [Thermoprotei archaeon]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KEPVDESARGDLDVLVGVTIYYGLLVRGLDLPERIRYAVFAGVPRFKFSM-------RV-DD-ASPIRLLSIASSIREY-L-PEP------EADEL-GRHIVRLR-RLL--ATSSQR---TLAELA-E--------VMR-GER-----ELT-GES-SHLAAILE-VVRDLRRSLQRLLSDKAVIESLMAS-KYL---SLR-EE-------DGE--LYL-YVPDTMTYLQASGRTSRMYAGGVSRGLSVVIV--DD--EKLLNGLMRQSK--WYSED-IEW------R-----------------RL------------DE------L-------DLKGVLEEIDRDRSVIRAL-RE-G
>WP_058939248.1 intein-containing reverse gyrase [Thermococcus celericrescens]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCLGRISD-ERLINKNPCSEC-L-----DD-TVTA----------------DSYFDLITA----VRSALKLRGTL-------E----EWE-RIY--SLENGLREVEGFFEKAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWH-AT-R--------G-K----KSYIVVPTTPLVVQT---VRKIR-KI----AEN-------A-GV---EVN-------------LAYYH-GNL--RKKEKE-EMLAKIQN-EDY-G------ILVTSAQWMARKFDEVL-KG--R-----HFDFIFVDDVDAFLKA-SKNIDRSLYLLGFND--EVIGKA-------WEIIRLKK---QMS---KYLNGR-AKDRE-------ER-LKE----LNAQ-------I-----------AELQRDIEEFKR--EN--P-IG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVADTYL----KPSK-----------------DI-KEHVE------------DLLTMLG-K---GGIIFTPIDQGLGY-------AEELADYLRER-GFRIELVSSK---N---RKALERFENGEADYLIGSATYYGSLVRGLDMPHLIRYAIFTGVPKFRFSI-------DL-ER-PTIYRALGLLSEVMDF-L-SDE------DRKQA-EKLHARLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PIENEF----HNHVLG-VFRELVEFLRKVLKDEEVLRKLAED-PFI---SLK-EE-------GGK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLLV--DN--EKVFNGLLRQMR--WRFTE-FKM------V-----------------PF------------EE------L-------NLDEVLRQIDEDREKVRLV-ME-G
>WP_074631395.1 reverse gyrase [Thermococcus thioreducens]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCLGRISD-ERLYVKNPCSDC-L-----DK-TAHA----------------DSYFDLITA----VRNALQLRGTL-------K----EWE-RIY--GLERGLREVEAFFEKAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWH-AT-K--------G-K----KSYIVVPTTPLVVQT---VKKLQ-AI----AER-------A-GV---EIN-------------LAYYH-GNL--RKKEKE-EMLAKIQN-GDY-D------ILVTSAQWLARKFDDVL-KG--R-----RFDFIFVDDVDAFLKA-SKNIDRSLLLLGFSG--EIIEKA-------WEIIRLKK---QMS---KYLNGR-AQDRE-------ER-LKE----LNAQ-------I-----------AELQREIEEFKA--KN--G-VG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVVDSYL----KPTK-----------------DV-KEHVG------------ELLRRLG-K---GGIIFTPIDQGLGY-------AEELVNYLRER-GFRVELVSSK---N---KKAIERFENGEADYLVGSATYYGSLVRGLDMPHLIRYAVFTGVPKFRFSI-------DL-ER-PTIYRALGLLSEIMEF-L-SDE------DRKQA-EKLHARLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PIENGF----HNHVLG-VFRELVEFLRNALKNEEVLRKLAED-PFI---SLK-EE-------GGR--WYI-EIPDVRTYIQATGRTSRLFAGGITRGLSVLIV--DN--EKVFNGLVRQMR--WRFTE-FKM------V-----------------PF------------EE------L-------DIDEVLRQIDEDREKVRLV-ME-G
>RLE97937.1 reverse gyrase, partial [Thermoprotei archaeon]
------------------------------------MLL-----------------------------------VR----------------------------------------------------------------------------------------AIVRGQCPNCGGPISD-DRLEKGLPCADC-LPK-P-SP-ELLE-LADR-----------GDRLRFLEE----LCNELSKAGRL-------K----GYR-RIL--EEEEALREFEQFFERAL-GNRPWSAQRTWARRVLGGKSFTILAPTGVGKSVFGIIMALYL-AS-R--------G-A----KCYLVLPTSVLVKQA---SERAE-AY----AEK-------L-GA---EVR-------------ILAYL-AK---SGKARE-ELLERIKS-GDY-D------VLITTSQFLARHFEL-L-EG--S-----HFDFIFVDDVDAVMKS-SRNIDKILVLLGLPS--EAVEEA-------YELVKLKL---KVA---AALSSR--------RGV-----PPE----MREE-------L-----------ERSRERLRKRLE--GL--R-IG-TL--VISTAT--GRPRGL-RVRLFRELLGFEIGSRAE-LLRNVVDAYS----LVEEGS----------------V-EERVA------------EIVKALG-R---GGLIFLQPGVGEDY-------VKRLLALLEEK-GIKAALVTSR---S---KEALEAFERGELDVLVGYAIYYGLLVRGVDLPHVIRYAVFAGVPHFRFTA-------EV-SE-AGPLRLLQLAQVLRSV-V-TGD------EGSAL-DRLTAKLR-RQL--ANLEAA---AFQRLS-E--------ALV-EGV-----KPE-GY----LGYLYE-LFEELRERLKDLLSRREVLEALEAR-TLA---SIR-FV-------DGK--PYL-LLPDAPTYLQASGRTSRMYAGGISRGLAVVVT--DD--EKLLSALMKQVS--WYVDE-VSW------T-----------------KY------------EE------L-------DLGEILKEIDEDRRKIRDL-WE-G
>RLE88711.1 reverse gyrase, partial [Thermoprotei archaeon]
------------------------------------MLL-----------------------------------VR----------------------------------------------------------------------------------------AIVRGQCPNCGGPISD-DRLEKGLPCADC-LPK-P-SP-ELLE-LADR-----------GDRLRFLEE----LCNELSKAGRL-------K----GYR-RIL--EEEEALREFEQFFERAL-GNRPWSAQRTWARRVLGGKSFTILAPTGVGKSVFGIIMALYL-AL-R--------G-A----KCYLVLPTSVLVKQA---SERAE-AY----AEK-------L-GA---EVR-------------ILAYL-AK---SGKARE-ELLERIKS-GDY-D------VLITTSQFLARHFEL-L-EG--S-----HFDFIFVDDVDAVMKS-SRNIDKILVLLGLPS--EAVEEA-------YELVKLKL---KVA---AALSSR--------RGV-----PPE----MREE-------L-----------ERSRERLRKRLE--GL--R-IG-TL--VISTAT--GRPRGL-RVRLFRELLGFEIGSRAE-LLRNVVDAYS----LVEEGS----------------V-EERVA------------EIVKALG-R---GGLIFLQPGVGEDY-------VKRLLALLEEK-GIKAALVTSR---S---KEALEAFERGELDVLVGYAIYYGLLVRGVDLPHVIRYAVFAGVPHFRFTA-------EV-SE-AGPLRLLQLAQVLRSV-V-TGD------EGSAL-DRLTAKLR-RQL--ANLEAA---AFQRLS-E--------ALV-EGV-----KPE-GY----LGYLYE-LFEELRERLKDLLSRREVLEALEAR-TLA---SIR-FV-------DGK--PYL-LLPDAPTYLQASGRTSRMYAGGISRGLAVVVT--DD--EKLLSALMKQVS--WYVDE-VSW------T-----------------KY------------EE------L-------DLGEILKEIDEDRRKIRDL-WE-G
>WP_088856074.1 reverse gyrase [Thermococcus siculi]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCLGKISD-ERLINKNPCDEC-L-----EE-PVHA----------------DSYFELVTA----VRNALQLRGTL-------K----EWE-RIY--SLEKNLREIEAFFERAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWH-AT-N--------G-K----KSYIVVPTTPLVIQT---VRKIQ-AV----AER-------A-GI---DIN-------------LAYYH-GNL--RKKEKE-EMLAKIQG-EDY-D------ILVTSAQWMARKFDEVL-KG--R-----HFDFIFVDDVDAFLKA-SKNIDRSLYLLGFND--EIIGKA-------WEIIRLKK---QMS---KYLNGR-AQDRD-------ER-LKE----LNSE-------I-----------SKLQREIEEFKS--KN--D-IG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVVDSYL----KPTK-----------------DI-KEHVE------------ELLMMLG-K---GGIIFTPIDQGLGY-------AEELVNYLRER-GFRVELVSSK---N---RKAIERFESGEADYLVGSATYYGSLVRGLDLPHLIRYAVFTGVPKFRFSI-------DL-ER-PTIYRALGLLSEIMDF-L-SDE------DRKQA-EKLHARLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PIENEF----HNHVLG-VFRELVEFLRKALHDEEVLKKLAED-PFV---SLT-EE-------EGK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKVFNGLLRQMR--WRFTE-FKM------V-----------------PF------------EE------L-------NLDEILRQIDEDREKVRLV-ME-G
>RLF35844.1 reverse gyrase, partial [Thermoplasmata archaeon]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------VVYEGLCPICNGDLRE-EEILEK----VC-FLK-N-------------------------------------------------------K--------KFDEICHNREEKDLEKLFEKVI-G-KPREIQKFWMRRICRGESFAAVAPTGIGKTAFGLVTSLYF-AM-D--------N-R----KSYIIVPTTLLVEQA---AEEIR-NF----CMR-------L-GL---KVGLNSEGD-----IPVAFYH-GRM--GGGEKK-AFGEILKE-AK---------ILITTAQFLSKRFDE-I-RD--L-----DFYFIFVDDVDAILKS-SKNVDKILNLLGFWK----------------------------------------------------E-GNE----WKGR------------------------------------NK--G-IL--MVSTAT--AS-RGK-ATRLFRELLNFDVGSSFF-TIRNVEDIIV----KGNG--------------------IDIVR------------NILKRMG-K---GGIIYASS---QEE-------AESYFEELKRD--FKIGIAISK--K----KNDYEEFEKGNLDFLIGTAAYYGTLVRGLDLPEKIRYVVFTRAPIIKVRYE------EL---------SPNMLKVLALI-FRKDER-----------------IK-KFLP----------ILPKLE-R---------------------------------YPK-RIEELKRIIKEVSSKEKV--------EDM---VI------------RD--KEI-LFPDVKTYLQGSGRASRLTVKGLTKGASFLCE--SD--ENILKTFIKRAS--YF--D-IFF------K-----------------EI------------EN------I-------DIEKLAVEIDKSR-----------
>WP_009074903.1 reverse gyrase [Metallosphaera yellowstonensis]
--------------------------------------------------------------------------MIT---------------------------------------------------------------------------------------SVFHSTCPNCQGPLED-FRALQGLPCTNC-LPG-EWSAYANL------------------PIEEKSKV----IYNLLVNNGKL-------A----RYW-ELY--YTLEAHKEMINYFKEVT-GKEPWSLQRLWLRRLSEGDNFSLSAPTGMGKTTTLIVHSAYL-S-------------K----NVLYLVPTKSLQEQI---CNRLG-EI----TS--------V-SC-------------------------GSM------------------NP--NA-----VSVLTVSYINRNFQA-L-SDY-------RPKFIAVDDADSIIKS-GKTTDKLVQLMGIPK--EVYEDA-------MRLVRLRR---LLVL--------------------REN-KEE----LMEK-------L-----------NDLENKIKSFSGP-------IA-QL--VVASAS--LRPKGI-KQKALRHISGFDISTAQT-YARNIVDSFT----------------------------TSSLE------------DVVERMG-P---GGLVLVSREYGKTV-------MRDIKDRLDGM-GFKVGLAIAG-------RKFLKDFSEGKTNILVGSASYYGVAVRGIDEPKALKYVVFYGVPKSRVSAMD-----AI----KNPY----TLLRVARL-L----------------GFEVP--EEEILT---LSPG---EAQAIK---------ISIL-QNQ-----KLE-G----RLGEVQQ-KVMGLIEEVSEALSRI-EDNIVGET---F---LLT-RM-------GRE--VYL-QYPDVITYLQGSGRSSRLLNGGLTKGLSVVIV--DD--QILFEIFKKKMN--YIIQG-FHP------E-----------------HF------------ES------L-------DLKGLREEIERTREE---------
>ADM27064.1 DNA topoisomerase (ATP-hydrolyzing) [Ignisphaera aggregans DSM 17230]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------MTLAIYRHGCPYCGSSIYV-GE--DSWSCENC--------------------------------------E----MINRFRHG----------N----SYV-D----VWFKEIRDFIEFFRMAT-GFSPWSLQTYWIKRLLSGESFAMVAPTGIGKSTLLGVYALYR-AY-F-------YR-S----KIYIITPTREIAKQF---YSKIS-EY----LRT-------I-SK---NFH-------GADKLRIIFYD-SSS---KNHK--DILKLINE-NMF-D------ILITSSSFLSRHHVI-V-DS--SK-----IDIVIADDLDSIMRN-SKSVDRVLKILGFDE--KIVNLA-------MELVKLKQ---SFYV-AKLAKSQ-------------ES-VEN----IRRK-------I-----------IEMEAILKNEVAK-----R-NT-QL--VVASAT--GRSAGM-KALILKELLGFDSGAIFE-YWRNIVDIYS----QIDD--KM----------------MIYIK------------EIIEKMK-S----GIIFVSSPYKDY--------IDVIVKKLMDM-NIKVAVVKSG-------NKAVDKFRRGEVDVLIGSSSYYGILVRGLDEPQRIKFVIFIGLPQIMKELWN-----SL----SNIRLLYMIAKCLN-----EQG------ID--L-SNDIKTLI-NII--QSSSPA---QLILLS---------KAL--NGR-----EYP-NDLRDKVEELAK-IRDRVYEEAKKFLDTN---GKLVIN-NYG---ILV-KL------GHRY---VI-LKPDPYTYIQASGRCSRLFNGIKTFGVSIVFE--NY--KELIELMEKKMK--RFVDG-FRF------I-----------------NL------------SD------A-------DIDEYVLRAESTRS-LNFS-GD-G
>WP_088862081.1 reverse gyrase [Thermococcus celer]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCFGRISD-ERLYLKNPCDDC-L-----DE-PVHA----------------DSYFDLVTG----VRNALQLKGTL-------K----EWE-RIH--SLEKGLREVEDFFRKAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAVMAVWH-AT-R--------G-K----KSYIVVPTTPLVIQT---VKKIE-AI----VER-------A-GV---EVN-------------LAYYH-GNL--RKREKE-EMLAKIQN-GDY-D------VLVTSAQWLARKYDEVL-DG--R-----HFDFIFVDDVDAFLKA-SKNIDRSLHLLGFDD--EVIAKA-------WEIIRLKR---EMS---RYLNGR-AKDGE-------EK-LRE----LNAE-------I-----------SKLQREIDEFKA--RN--D-IG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVVDTYL----KPDK-----------------GI-KEHVE------------ELLARLG-K---GGIIFTPVDQGLSY-------AEELAAYLRER-GFRIELVSSK---N---KKAIERFENGEADYLIGSATYYGSLVRGLDLPHLIRYAVFTGVPKFRFGM-------DL-ER-PTIYRSLGLLSEIMDF-L-GDE------DRKKA-ERLHARLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PMENAF----HNHVLD-VFRELVDFLRSALKDEEVLRKLAED-PFV---SVK-EE-------GGK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKVFNGLVRQMR--WRFTE-FKM------L-----------------PF------------EE------L-------DLDGVLREIDEDREKVRLV-ME-G
>WP_048099323.1 reverse gyrase [Candidatus Acidianus copahuensis]
--------------------------------------------------------------------------MVT---------------------------------------------------------------------------------------SVYQKFCPNCGGSIED-FRALQGLPCTSC-LPG-DSTGFSNL------------------TQAEKIKS----VYHLLVKGNKL-------K----AYW-NLY--YSLELSEEVIRHFSGVV-GHEPWSLQKLWLRRLAEGNSFSMSAPTGMGKTTTIIAYSTYL-K-------------E----GVLYIVPTKPLLQQI---CKKIG-GI----VER-------V-NC-------------------------GNV------------------GD---G-----ISLVTVNYINRNFEQ-I-KEY-------RPKLIAVDDADALVKS-GKTVDRLVTIMGIPD--GVYEDA-------MRLVRLRR---LLVF--------------------EEK-REE----VEKK-------I-----------AELERRISSFNST-------VA-QL--VVASAT--LRPRGI-KQKALKYITGFDMGTVQI-YARNIIDSYR----------------------------HSLDL------------GIIDELG-A---GGLILVSRDYGKEK-------IKEVKAELESK-GYKVSLATSG-------KKFLEDFSSGKVDFLIGSASYYGVAVRGIDEPKRLKYVVFYGVPKSKIRAGD-----AI----LNPF----TLLRVSRL-L----------------GVNID--EEKILS---LNPA---EAQVIK---------IALL-KSQ-----RLS-G----KLGEVQD-YITERVKEIREKFKSL-PDQIIGET---F---ALK-RI-------GKE--VYL-EFPDAITYLQGSGRSSRLVNGGLTLGLSITLI--DD--DVLYGMLTKKLK--YLVYG-FSP------S-----------------KL------------ED------V-------DLSSVKKEIVRSREE---------
>WP_012940323.1 reverse gyrase [Archaeoglobus profundus]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------AIYKNLCHVCGNDFDT-EEAEKG----VC-KKK-N-------------------------------------------------------R--------IMCRFYEDFIVEEFFKFFEKIV-G-EPRAIQKFWAKRILRGESFAAVAPTGIGKTTFGSAIALFL-AL-K--------G-R----KCYIILPTALLVKQV---VENLE-KF----CEK-------L-DL---KAGFNELGD-----PTILYYH-SDI--KKDERE-RFFKLLEE-GKF-N------ILVTTAQFLPRYFPQ-M-KH--L-----RFNFIFVDDVDSVLKA-SKNVDRILQLLGFYY--D------------------------------------------------AN-EKK----WKGK------------------------------------AR--G-CL--MVSTAT--AK-KGQ-KVKLFRELLNFDVGTSTH-AVRNIEDVAI----NSED--------------------INILR------------QILKKMG-T---GGLIYART---TEE-------AEKLYEILKDE--FKIGIVTAG--R----KKDFDLFAEGEIDYLIGTAYYYGTLVRGLDLPERIRFCVFYGAPVFRVRVE------DV-D-----TASVGIIKVLAMI-FRDNEE-----------------VK-KFIP----------YLAVID-K---------------------------------RPE-DLEQLKSILKKLIEQGEVKE------RDI---VV------------RK--GEI-IFPDIRTYIQGSGRTSRLFAGGITKGASFLME--ED--PEIFNAFIERAK--FY--D-IEF------K-----------------SL------------ED------V-------DFEKLIKEIDESRERY----RR--
>WP_042667859.1 reverse gyrase [Desulfurococcus amylolyticus]
--------------------------------------------------------------------------MP------------------------------------------------------------------------------------GAFNPLYKGFCPVCGGDILS-SEVELRGFCSRC-ANS-GLTS-----------------------------------------------------------I-LRD--ITSSGLGDFEEFFRRASNGLSVWGAQKIWAKRLVSGENTVLIAPTGMGKTTLLIIYSLYA-AR-R--------G-K----RVVYITPTRTLLTQI---HRRLV-EA----AER-------T-GI---NG------------VNLIAYD-SSM--SKKKRE-EVLSRIEK-GEY-S------ILVATNGFLSRKSEL-L-SR--SR-----PDIVIADDVDSVVRS-EKNVLRLLRILGYSD--EVIELA-------KKRISLLW---RLMV-NKAFNNN-------------DK-YAE----LVKE-------Y-----------IEVDSLIEKTLSS----TR-HA-QF--IVASAT--GRMKGL-MGRILKELLHVDISGVTI-YGRDVTDAYM----LIKP-GEL----------------HGELA------------RIIEKLG-P---GGIIYIAPHHPFKN--MLKEELDKAVNILADK-GFRIGDATPG---------NVARLIKGELDILTGSASYYGSSVRGIDAPEAIRYVVFIGSPVFATSLES-----LL----ANPGMMIRVLLELV-----D-S------ND--A-RNRVLELR-RLL--YTLTPG---EVRLVK---------LALT-GKILEEALQAS-EKLYSKYQVIKQ-YYRETLERTRSILDEK---GIMDIG-TLT---LVR-A--------GGD--YYA-LIPDVMTYIQASGRTSRLYGSRMTHGLSIVFE--YRALYNTVKGLEARLK--GLNKE-LVF------I-----------------DL------------AS------V-------DLDSEIKAIESSRRNNDS------
>PMP68992.1 reverse gyrase [Caldisericum exile]
------------------------------------------------------------------------METIP---------------------------------------------------------------------------------------TIYKNLCPNCGNDIDD-ERLKLGLTCKVC-LEK-I---------------------------VP-KEQ----IC------NYL-------K--IDQFQ-PVC--NLRTHMQRFKKTFENIT-GFTLSSLQEMWATRFFLDNSFALIAPTGIGKTTFGLALSKYI-SE-N-------NI-G----FVYLIFPTNILVKLA---KEKLL---------T-------F-GI---EEN------------DIIAYD-SNLPKNTL--E-VLKYRIQE-GDF-K------ILITTTNFLYKNFDI-V-P---KG----LYSLVLIDDVDSILKN-SKNIDKVLKLLNFND--NDIEKA-------LKLIDLKR---LS-------------IKN------KA---------NPQT-------L-----------QSAIEEVNK-IK--EK-RK--G-VL--IVSSAT--TNPKSK-KVLLFRELLDFEVGRVVS-TLRNVVDAYK----IT-----------------QDDL-TKAAL------------SEIKKLG-K---GGLVFLNADYTKED-------LEKFVQLLNKN-GVKAASYENL--A-----KVLKDFKEGNLDVLVGFSTYRNPLARGIDLPSVIRYALFLGVPKMKFSL-------ST-T--EGNRGIYYAILLLIPH-I-TRKKILPESEMTKI-FRHLNILK-RYS---------------------------NFV-EEG-----IES-------PY--QK-AYNEAINYFKELLNREDILKIVEET-PDI---ALH-RK-------GNE--LSF-IVVDITGYIQASGRTSRLIATGLTKGLSLILT--ND--FKMLSVLRKKLK--WFIGE-GDL------L-----------------PY------------ES------L-------DLESILREIDNDRALAQKI-ES-G
>PMP83216.1 reverse gyrase [Caldisericum exile]
------------------------------------------------------------------------METIP---------------------------------------------------------------------------------------TIYKNLCPNCGNDIDD-ERLKLGLTCKVC-LEK-I---------------------------VP-KEQ----IC------NYL-------K--IDQFQ-PVC--NLRTHMQRFKKTFENIT-GFTLSSLQEMWATRFFLDNSFALIAPTGIGKTTFGLALSKYI-SE-N-------NI-G----FVYLIFPTNILVKLA---KEKLL---------T-------F-GI---EEN------------DIIAYD-SNLPKNML--E-VLKYRIQE-GDF-K------ILITTTNFLYKNFDI-L-P---KG----FYSLVLIDDVDSILKN-SKNIDKVLKLLNFND--NDIEKA-------LKLIDLKR---LS-------------IKN------KV---------NPQT-------L-----------QSAIEEVNK-IK--EK-RK--G-VL--IVSSAT--TNPKSK-KVLLFRELLDFEVGRVIS-TLRNVVDAYK----IT-----------------QDDL-TKAAL------------SEIKKLG-K---GGLVFLNADYTKED-------LEKFVQLLNKN-GIKAASYENL--A-----KVLKDFKEGNLDVLVGFSTYRNPLARGIDLPSVIRYALFLGVPKMKFSL-------ST-T--EGNRGIYYAILLLIPH-I-TRKKILPESEMTKI-FRHLNILK-RYS---------------------------NFV-EEG-----IES-------PY--QK-AYNEAINYFKELLNREDILKIVEET-PDI---ALH-RK-------GNE--LSF-IVVDITGYIQASGRTSRLIATGLTKGLSLILT--ND--FKMLSVLRKKLK--WFIGE-GDL------L-----------------PY------------ES------L-------DLESILREIDNDRALAQKI-ES-G
>WP_012608900.1 reverse gyrase [Desulfurococcus amylolyticus]
--------------------------------------------------------------------------MP------------------------------------------------------------------------------------GAFNPLYKGFCPVCGGDILS-SEVELRGFCSRC-ANS-GLTS-----------------------------------------------------------I-LRD--IASSGLGDFEEFFRRASNGLSVWGAQKIWAKRLVSGENTVLIAPTGMGKTTLLIIYSLYA-AR-R--------G-K----RVVYITPTRTLLTQI---HRRLV-EA----AER-------T-GI---NG------------VNLIAYD-SSM--SKKKRE-EVLSRIEK-GEY-S------ILVATNGFLSRKSEL-L-SR--SR-----PDIVIADDVDSVVRS-EKNVLRLLRILGYSD--EVIELA-------KKRISLLW---RLMV-NKAFNNN-------------DK-YAE----LVKE-------Y-----------IEVDSLIEKTLSS----TR-HA-QF--IVASAT--GRMKGL-MGRILKELLHVDISGVTI-YGRDVTDAYM----LIKP-GEL----------------HGELV------------RIIEKLG-P---GGIIYIAPHHPFKN--MLKEELDKAVNILADK-GFRIGDATPG---------NVARLIKGELDILTGSASYYGSSVRGIDAPEAIRYVVFIGSPVFATSLES-----LL----ANPGMMIRVLLELV-----D-S------ND--A-RNRVLELR-RLL--YTLTPG---EVRLVK---------LALT-GKILEEALQAS-EKLYSKYQVIKQ-YYRETLERTRSILDEK---GIMDIG-TLT---LVR-A--------GGD--YYA-LIPDVMTYIQASGRTSRLYGSRMTHGLSIVFE--YRALYNTVKGLEARLK--GLNKE-LVF------I-----------------DL------------AS------V-------DLDSEIKAIESSRRNNDS------
>BBD72651.1 reverse gyrase [Sulfodiicoccus acidiphilus]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MYSVLVDNGKL-------S----AYW-ELY--DRLQRFEEARRFFEEKV-GYSPWNLQLFWLRRLVAGDSFSMSAPTGLGKTTTLITYASLL-SQ-R--------G-K----RTVYIVPTKSLMQQV---CDKIK-EM----SVR-------L-GC-------------------------GVP------------------RF--EG-----IDVITYQYLNRRAEG-G-MGV-------VYDFVAVDDADAIIKS-GKTVDKIVPLLGIPE--QVYKDT-------IRLVKLRN---ALRF--------------------YITVDQEKAEKLAKD-------V-----------EEIERRVVESRSS-------YS-QF--VIASAT--AKPKGI-KQKAMKFLLGFEPSTVQI-YMRNVLDSYT----------------------------QLDPT------------EIVTKMG-K---GGLILVSRDRGKAG-------ILELKERLESK-GIKVGLALNG-------RRFLKDIVEGKVDVLLGSANYYGVAVRGIDEPRAIRYVVFHGVPKVKLSLKA-----AL----FNPF----IVSSLASL-L----------------DLEARELQTTLSS---LNPS---EAQMLK---------VAMW-RGE-----QLT-G----KLKEAKR-ALEEMGELVREALKRR--RKVIGKY---F---VVA-GE-------SEK---YV-VFPDVVTYIQGSGRASRMINGKLSFGLSVTVV--DD--QEVYELMKTRMG--NYMDK-FEP------V-----------------KF------------DD------L-------NLTEISRAIDTSRSGV--------
>RLE48014.1 reverse gyrase, partial [Candidatus Verstraetearchaeota archaeon]
--------------------------------------------------------------------MRER--LH----------------------------------------------------------------------------------------AVFKEGCPNCGGEIAD-IRLKNKLPCRFC-IPL-P-DD-GLIE-KISK-----------LNEVERLKF----ILNLLKKFKTL-------K----NYG-SLA--ALEEEVASVNKLFERAT-GSRLWSAQRTWCRRALSGKSFAIIAPTGMGKTVFGIILSIYF-AS-K--------G-K----KAYILLPTSLLAYQV---SSKVK-NF----IEK-------L-KL---NIK-------------AVEYH-SIL--TRSKAR-KALEEIAE-GDY-D------ILITTSYFLPRHFEK-I-SK--Q-----KFDLIFVDDVDSFMRT-SKNVDKVLVLLGLKQ--EIIELG-------FQAMNLRS---KLR---KLLRMR--------RAR-QED-LNL----VREE-------L-----------IKVENEIEDYKK--NE--K-IG-LL--IVSGAS--IRTRRTKRVKLFKELLGFELGGKAE-GIRNIIDMHV----KAE--R----------------V-LDKVV------------ELVKELG-G---GGLVFVPMDKGAAY-------VKRVAEALEAQ-GVKAATYERA---R---GKILERYRAGEYDVLVGIASYRSPLARGIDLPERVRYAIFAGVPKIKISL-------DI-DE-FRPSKAIILLANLRDF-VETQR------EVDSI-DKYIADLR-RFS--GMLRRD---EIEKIV-E--------SIK-AGE-----KLE-GF----LGRVQQ-LFMEVIRFLRSLLSRDDIRRKIRES-PYL---TM--EG-------ESK--PVI-VVPDAVGFLQASGRTSRMYAGGVSKGLAIIVI--DN--EKAFNGLVRELK--WYVED-VKF------T-----------------EL------------TP------E-------KLRKAIRKVDEDREIIRKL-RE-G
>RLE53869.1 reverse gyrase [Candidatus Verstraetearchaeota archaeon]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLSEIA-S--------KLT-EGV-----KPT--------TDAER-VFYEALQVLRDYLARSDIEDKLKKL-EDI---RLV-EE-------EGK--TFI-LIPDVMTYIQASGRTSRMFAGGLTKGLSIVVV--DD--DHLLKGLIKRSK--WIIDD-IEW------R-----------------EL------------KE------V-------DLKSILAEIDRDRLVVKQL-RE-G
>WP_048148107.1 intein-containing reverse gyrase [Palaeococcus ferrophilus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AVYREMCPNCGDRISD-ERLIKKNPCEEC-L-----ES-DVHA----------------HPYFDLLRA----VREALAVRGTL-------K----EWE-RLY--TIESQLGEVEKFFIEAT-GNNFWSAQRTWVRRLLKGKSFSIIAPTGMGKSVFGSFMAYYY-AL-Q--------G-K----KSYIILPTTPLVKQT---VKRLQ-AF----MER-------T-GK---EVK-------------LAYFY-SGM--RKKEKE-EMNARIDG-GDF-E------ILITSAQFLARKFE-RL-EG--F-----RFDYIFVDDVDAFLKA-SKNIDRSLLLLGFTQ--EALDKA-------WELVRLRK---QIG---KLLNGRRTEEKE-------EE-LKR----VNEE-------I-----------AKKEAELREYMA--QK--N-IG-TL--VIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVEDVYL----FPEK-----------------SV-EEHVE------------GLLGKLG-P---GGLVFVPIDQGIAF-------AEALTARLKEK-GFSVELVSAR---S---KKGLEKFENGEVEVLVGMASYYGSIVRGLDMPERVRYALFTGVPKFKFSL-------DL-EG-PTIYRVLGLISEIFDF-L-DDE------DRREG-ERVYARLR-RLI--RTMPQY---ELVKIE-E--------ALA-EGL-----PLE-GY----HNHVLD-VFRTAVEFLKRVLRKEEVVKRIEED-PFI---SLK-RE-------GDK--VFI-EIPDVRTYIQASGRTSRLFAGGITKGLALTVV--DN--VKVFNGMRRQLR--WRFPE-FEW------K-----------------SL------------EE------V-------NLDEVLRQIDEDREKVRLV-LE-G
>WP_088858354.1 reverse gyrase [Thermococcus profundus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCLGRISD-ERLINKNPCDEC-L-----DE-PVHA----------------DSYFELITA----VRNALKVKGTL-------K----EWE-RIY--SLEKNLREIEGFFERAT-GFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWH-AT-K--------G-K----KSYIVVPTTPLVIQT---VRKIQ-AV----AER-------A-GI---EIN-------------LAYYH-GNL--RKKEKE-EMLAKIQG-EDY-D------ILVTSAQWMARKFDEVL-KG--R-----HFDFIFVDDVDAFLKA-SKNIDRSLYLLGFND--DIIGKA-------WEIIKLKK---QMS---KYLNGR-AQDRE-------EK-LKE----LNSE-------I-----------SRLQREIEEFKR--EN--K-IG-IM--IIASAT--GSARGD-RIKLYRELLGFEVGSGRS-ALRNVVDSYL----KPTR-----------------DI-KGHVE------------ELLTMLG-K---GGIIFTPIDQGLGY-------AEELVNYLRER-GFRVELVSSK---N---KKAIERFENGEADYLVGSATYYGSLVRGLDLPHLIRYAVFTGVPKFRFSI-------DL-ER-PTIYRALGLLSEIMDF-L-SDE------DRKQA-EKLHARLR-RLI--RNIPQF---ELLKIE-E--------ALA-EGL-----PIENEF----HNHVLG-VFRELVEFLRKALHDEEVLKKLAED-PFV---SLT-EE-------EGK--WYI-EIPDVRTYIQATGRTSRLFAGGITKGLSVLIV--DN--EKVFNGLVRQMR--WRFQE-FKM------V-----------------PF------------EE------L-------DLDEILKQIDEDREKVRLV-ME-G
>WP_013737086.1 reverse gyrase [Metallosphaera cuprina]
--------------------------------------------------------------------------MIT---------------------------------------------------------------------------------------SVFHSSCPNCQGPLED-YRALAGLPCTNC-LAG-DEEPFRDL------------------PQSEKIKA----VYNLLVNNNKL-------A----KYW-ELY--YTAEMYDEVINYFNQVV-GKEPWSLQKLWLKRLGERENFSLSAPTGMGKTTTLVAYSSYL-S-------------K----GVLYIVPTKSLQEQI---CSKIG-SI----SS--------V-SC-------------------------GYV------------------DR--DG-----ISVLTVSYVNKKYES-I-KDY-------RPTFIAVDDADAIIKS-GKTTDKLVELMGIPK--DIYEDA-------MRLVRLRR---SLYL--------------------KED-KDE----ILEK-------I-----------TKLERKIQGFTGA-------IA-QL--VVASAT--LRPKGI-KQKALRYISGFDLSNTQT-YARNIVDSFS----------------------------CSSIE------------EVVQRLG-P---GGLILVSREYGKEK-------MREIKDKLTSN-NFNVELAISG-------RKFLQNFSEGKTDILIGSASYYGVAVRGIDEPKRLRYVLFYGVPKSRARAEE-----AI----RNPF----TLMKIARL-F----------------GVNVP--EDEILS---LSPA---EAQAIK---------ISII-KGQ-----VLP-G----KLGEVQK-KLEDKISEVQEFLKSV-NGIVRGET---F---LIS-RR-------GKD--VFI-EYPDVITYLQGSGRSSRLLNGGLTQGLSVILV--DD--QILFDLLKKKMN--FIIQG-FNP------V-----------------QF------------ES------L-------NVDSITKEIERTRRE---------
>WP_012021690.1 reverse gyrase [Metallosphaera sedula]
--------------------------------------------------------------------------MIT---------------------------------------------------------------------------------------SVFHSSCPNCQGPLED-YRALAGLPCTSC-MPG-SVDSFKDL------------------PQEEKIKV----VYNILVNNGKL-------G----KYW-ELY--YTTEMYNEIINYFKQVT-GNEPWSLQRLWLRRLGERENFSLSAPTGMGKTTTLITYSTYL-S-------------K----GVLYIVPTKSLQEQI---CSKIG-AI----SS--------V-SC-------------------------GKV------------------DP--NT-----ISVLTVSYVNKNYDH-M-KDY-------RPNFIAVDDADAIIKS-GKTTDKLVELMGIPK--DVYEDA-------MRLVRLRR---MLYL--------------------KDN-KDE----IVEK-------I-----------ALLERKIQSFTGI-------IA-QL--VVASAT--LRPKGV-KQKALRHISGFDISTAQT-YARNIVDSFT----------------------------FSSLE------------EVVQKLG-P---GGLILVSREYGKEK-------MKEIKESLTSL-NFRVELAVSG-------RKFLQDFSDGKTDILVGSASYYGVAVRGIDEPKRLKYVLFYGVPKSRTRAEE-----SV----KNPF----TLLRVSRL-L----------------GIQVP--EEEILG---LSPA---EAQAIK---------IAMI-TGQ-----SLE-G----RLGALLE-KMKVLVEEAQEALRKV-DGTITGET---F---QIS-RK-------GRE--VFI-EYPDIITYLQGSGRSSRLLNGGLTQGLSVILV--DD--QVIFELFKRKMN--FLIPG-FAP------V-----------------NF------------EA------L-------ELDRVKEEIERTRRE---------
>WP_014768093.1 reverse gyrase [Desulfurococcus amylolyticus]
--------------------------------------------------------------------------MS------------------------------------------------------------------------------------GAFNPLYKGFCPVCGGDILS-SEVELRGFCSRC-ANS-GLTS-----------------------------------------------------------I-LRD--IASSGLGDFEEFFKRASNGLSVWGAQKIWAKRLVSGENTVLIAPTGMGKTTLLIIYSLYA-AR-R--------G-K----RVVYITPTRTLLTQI---HRRLV-EA----AER-------A-GI---NG------------VNLIAYD-SSM--SKKKRE-EVLSRIEK-GEY-S------ILVATNGFLSRKSEL-L-SR--SR-----PDIVIADDVDSVVRS-EKNVLRLLRILGYSD--EVIELA-------KKRISLLW---RLMV-NKAFNNN-------------DK-YAE----LVKE-------Y-----------IEVDSLIEKTLSS----TR-HA-QF--IVASAT--GRMKGL-MGRILKELLHVDISGVTI-YGRDVTDTYM----LIKP-GEL----------------HEELA------------RIIEKLG-P---GGIIYMAPHHPFKN--MLKEELDKAVNILADK-GFRIGEATPG---------NVARLIKGELDLLTGSASYYGSSVRGIDAPEAIRYVVFIGSPVFATSLES-----LL----ANPGMMIRVLLELV-----D-S------ND--A-RSRVLELR-RLL--YTLTPG---EVRLVK---------LTLT-GKIPEEALQAS-EKLYSKYQVIKQ-YYRETLERTRSILDEK---EIMDIG-TLT---LVK-A--------GGD--YYA-LIPDVMTYIQASGRTSRLYGSRMTHGLSIVFE--YRALHNTIKGLEARLK--GLNKE-LVF------I-----------------DL------------TS------V-------DLDSEIKAIESTRRNNDS------
>GAY25827.1 reverse gyrase [Desulfurococcaceae archaeon AG1]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWSIQRAWARRLLKGSSLVLTAPTGSGKSTLVQAYSLYM-AS---------KG-Y----SVYLVVPTRELLRQS---VDRIS-SM----ASR-------S-SA---R-------------VRIAYYD-SSA--KKDLRE-KALDVIRA-GEY-D------LLATTSSMFTKISGI-L-SE--RR-----FDIVVADDLDSLIKS-SRNLEGILSLVGVSR--EEIELA-------LKIASKKY---EIAL-ARASKDPG-------------E-LEK----SREE-------I-----------EVLKAELALSLSR----KR-LG-QL--VVSTAT--GKSWGL-RSKILREILGFEVGGILE-YMRNIIDAYT----QPGGDD------------------IDSLE------------DLLKTLG-S---GTIIYFSRGYDDEK-------ISEIINNLSQR-NLRIGIYKPG-------GRSLRKFLEGELDFIAGKASFYGSLVRGLDEPLRIRNAVFIGIPKHVIPLKS-----YL----ADLRNLALFYKSTD-----S--------------QDTYREIY-RLL--RRLPPT---LPPVIK---------KILK-GYA-----EAG-ESLRETIDLIKG-WISSAIPIARQRCR-----DGIELG-G-S---LIM-CP------GNSE--PVA-VIPDAMTYIQASGRTSRLFSGGMTLGLSIVIP--ES--LELLSLLYKRLK--RYIPE-LVF------R-----------------EY------------RE------L-------DLKGIRREQERSRN----P-GS-M
>RLF25386.1 reverse gyrase, partial [Thermoprotei archaeon]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YIQASGRTSRMFAGGISRGASIVIV--DD--KKVFEGLVRKSR--WIVED-IEW------K-----------------AL------------EE------V-------NIKELIDEIDRDRNIIKML-RE-G
>PVU71061.1 reverse gyrase [Sulfolobus sp. SCGC AB-777_L09]
--------------------------------------------------------------------------MLK---------------------------------------------------------------------------------------IRYLFGCPNCNGPITA-DRLTKGIPCENC-LPG-VEGELD-------------------------VKT----IYELLLQNSSL-------K----GYA-ETY--YNNLLNKQVEELFERVV-GKKPWPIQQYWLRKLVRGESFSLSAPTGVGKTTTLIVYSIFF-G-------------Q----TSLFIVPTNSLKDQI---CKRLK-AH----YQE-------V-SC-------------------------DKP------------------EE--NK-----INVTTFYAINKRTSE-Y-SSL-------RPKLVIVDDADMILKS-GKTTENIAKILQIPD--QVFDSA-------LQLVKLRR---LLKV--------------------KED-E-E----VRKR-------I-----------IELEGFIFGNWHF-------SS-QF--IVSSAT--LRPKGL-KQLALRLLTGFEPSTIQI-YNRNIIDAFY----------------------------DSLDL-----------YEVITKLN-DD--GGLILVSKDLGRSK-------INEIYELLKNN-GIRVEKAISG-------RKFIDKLSAGEVDFLVGSASYYGVAVRGIDEPKRIKYVIFYGIPKYKLPLEE-----AL----NNPL----TTVKVAEG-L----------------SIDVKDLKKKLLL---LSPS---ELQMIK---------ISIK-KSE-----KLE-G----KLKELQE-KIVKLKESIIDTLSSRKINKLLLDS---S---VIK-RE-------NKA--YYI-LMPDIITYLQGSGRASRLYNNTLTLGLSILLV--DD--KDLFDILQKRLK--NLYSD-FKF------V-----------------NL------------NE------I-------DIEEVKVKINETRND---------
>PNV81326.1 reverse gyrase, partial [Fervidicoccus sp.]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-D------ILIITTSFLSRRFDV-L-KN--KV-----FGLIVVDDADSLLKD-SANVDRVLVLSGFKE--HEISAA-------MKIIKIRN---ELYF-LKIANRS------------NEK-IES----LERE-------L-----------EELEIIVAKARGE----GS-RG-QL--LISSAT--GRQSGI-KPKLFKELLGFEVGGIHA-YMRNVIDSYA----ILNKEEET----------------RDKVL------------ELVKTLG-S---GGLIFISRDKGVFE-------AKSLVSYLVSN-GIRAELAIAG-------KKSIEKLRRGEADVLVGVSSYYGVAVRGVDLPEKVRYAIFYGVPKNRMLLEQ-----SL----INPRRLLQVLAHLS-----ENE------DK--L-KSIFSELT-GRL--SKLTPS---EINVLR---------IALM-KEEI---EGLG-DWLRAIAESIIN-AIKEIKIVLKNKMKVKES---ISVG-T-A---IIV-RE------GEEE--FYL-ISPDPLTYIQASGRTSRFLNDKMTLGLSIILE--SN--REIIEAFERKMS--IYSRN-FSL------K-----------------PL------------EA------V-------DLRETSMMLDSSRR-------G-G
>RLI23239.1 reverse gyrase [Candidatus Bathyarchaeota archaeon]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLKALEES-PYI---GLE-KR-------GDV--FYL-IIPDPVAYIQASGRVSRMYAGGVSKGISIVLV--DN--DRAFNGLMRETR--WFMED-IVW------R-----------------RL------------SE------V-------DLDKVVEEVDRDRRAIKDL-LE-G
>KUO84529.1 reverse gyrase, partial [Thermoproteus sp. CIS_19]
--------------------------------------------------------------------------MD----------------------------------------FR-------------------------------------------ALPALYLHSCPNCGGAVES-YRLAEGLPCSEC-LPR-EAA-------------------------GGDIKR----IIEDLRRRNAL-------R----ELA-PLA--DNLRRYEEIGGLFERVV-GFRMWGAQRLWARRLAAGKSFAVVAPTGSGKTTFLLVSALYM-AG-R--------G-K-----ALLVFPTSALAYQA---YRKLL-DY----SSR-------G-GL---ALR-------------IATYN-TML--KPQERE-EALRRIEA-GDF-D------ILVITSAFLPKYFDL-L-AR--H-----KFAFVATDDVDSVLRATSKNIERLLKLLGATD--EVLGKA-------FELIELGK---RRG---KALL-A----GD------EKE-AER----IEHE-------I-----------EKAREELRKMRE--EL--R-LG-VF--IASGAL--ARARRTARLLLFREILGFDVGGRAE-GLRNVYDLYV----KMSE-----------------DP-KAQVA------------ELVKRLG-A---GGIIYVLD---REF-------GKELTQHLQAL-DIKAEHFFRP---R---RKVLEAFEQGQLSVLVGLASSRSALVRGIDLPHVIRYVVFVGIPKFKFRV-------EL-DE-FSVPAFLSFLYNVRAV-L-PQD------LRFKA-DRLIARLR-RIAP---YSA----RLDKIL-R------------EGA-----S-N-SF----EEYVLD-VARSAVEFAADLLSRGDVRKAIETS-TEI---KLT-YI-------GDQ--LYI-LLPDATTYIQGSGRTSRLYAGGLSRGLSVILV--DD--EKVLNALIREME--LRFDD-VRF------E-----------------EL------------SK------A-------DLDSILRGVDEDRENIRRI-LS-G
>RLG97493.1 reverse gyrase, partial [Candidatus Bathyarchaeota archaeon]
-------------------------------------MVR-------------------------------ESKMTL---------------------------------------------------------------------------------------VVYEGLCSVCNGDLRH-EEIEGK----RC-EVK-G-------------------------------------------------------V--------PFILSFQRDEEREFEEFFERAV-G-KPRELQRFWMKRLVRGESFAAVAPTGIGKTAFGLAFSLFY-AL-K--------G-K----KSYILVPTTFLVGQC---VEWLN-EF----GKK-------A-SM---RVKVNEEGE-----VTVAFYH-GRM--RKNEKE-RFEKLVRR-GSF-D------ILVTTTSFLSRRFND-L-KG--R-----VFDFIFVDDVDAILKS-SRNVGRVLFLLGLRK----------------------------------------------------E-PDG----WVGS------------------------------------PK--G-VL--MTSTAT--AT-KGK-STRLFRTLLNFDAGSSFF-TVRNVEDIAV----NGVD--------------------VEKVK------------EVLRRMG-R---GCLLYVRT---AEE-------VERWHNILKDE--FKIGMITAE--R----KRDYELFKDGRIDHLVGTSHFYGLLVRGLDLPEKIRYVVFIGAPTMKFRYE------TL---------TPKVIKILALI-FKRNEK-----------------IR-RYLP----------IIMNLE-R---------------------------------HPD-KLEEMRNLIRIVSKTEEA--------EDI---IV------------SE--DEI-IFPEVRTYIQGSGRTSRLTAHGLTKGASFLFE--DD--ERLLKAFLKRAE--YY--D-VSF------K-----------------SL------------DQ------V-------DLDSLSEEIDESR-------RR--
>PMB79968.1 reverse gyrase [Candidatus Korarchaeota archaeon]
----------------------------------------------------------------------MRDELSP---------------------------------------------------------------------------------------AQFHA------------------------------------------------------------------AIARALKEEGTY-------A----DYD-LVV--KMDELSASFSSFFEGIT-GEKPWKEQESWAVRVLSGESFALVAPPGVGKSVFSEVMALFL-AS-R--------G-K----HVIFLTPTTLLASQV---SRRLR-AF----SKG-------L-GT------------------SVAEFTSSALKVEKGSPD-DSVVVLTS-----N-------GL-RVHFEELMRTR-F-------------DVAFVDDVDAVLRS-SKNVERLLRLLGYGS--DELELAAKIAFGRLNAVRLAR-------------------RD------PES-AKK----ALLE-------V-----------EELETKVPR--------HS--A-QL--VLTSAT--AKTRGK-GAALLDALLGMNIEGGMG-GTRNVVDVKL-----------------------KGDL-VEKAI------------EEVQRLG-A---GGLIFVSHDLGSKF-------AKDLYQKMKEK-GLPVGFAEGK--RS---VKLIQEFEKGKVLALIGMASYYGPLVRGLDLPATVRYALFVGVPKFMFKISD--------DE-TNPLRIYQLLWELGTV-L----------NDPEA-RKLASEIR-RMIR-P-LSQE---EFKALE-NHV--KTGKGIP-KGK---DGEQS------YMEKLVD-KLSQARGKLSSLLRAEGAVDALKKS-PRL---IIR-EK-------AGS--LYL-VVPDLMTYLQASGRTSRIGREGFTTGLSEVIV--DE--EAAMDALERQAK--LYIQD-MEW------R-----------------EV------------ND------V-------DWEQLLRRMTLERN---------G
>RLG47811.1 reverse gyrase, partial [Candidatus Korarchaeota archaeon]
--------------------------------------MKV-------------------------------TPVIP---------------------------------------------------------------------------------------AVYRGLCPGCGGDLRV-HEGGC-----KC-GVE-T-------------------------------------------------------E--------YEK---IEEMASELYSLFRDCV-GSDPWQIQRVWGKRVVMRQSFAALAPTGVGKTAFGLVAALYH-PL-K--------GWG----KSIVIVPTVLLVSQA---ERLLR-GY----VENSARWWG---GE---G-------------PDILSYR-SSA--SRAERE-ESLSRIEA-GEF-D------VLVITSQFLARHHNL-L-RG--D-----GVGFVFVDDVDSFLKA-SRNVDRLLEVIGFSA--EEVERA-------L----------------------------------RDP-TYR----PEKR------------------------------------PD--T-VL--MLSTAT--GK-PGR-RAALFRRLMGFDVGVIREGALRNVEDVVV----GEKS--------------------VKRLS------------KILEMCG-S---GGLLFVPR---SAE-------AEEALRAAEMA-GLKAQVVVGS--E----EEAIELFKSGEVDLLIGAARPYGVLVRGINLPERIRYSVFYGAPRFEVGLS------SV-ED-MSEGAVSSILSVLSAS-LGARAR----------------GLA-VRIR-----------------RG--------------------------------DEE-ALSRGRELIREVLGDRERLEAAAKS-AGV---IV--EV-------EPE--PKI-VIPDVRTYIQGSGRTSRLYPGGITRGISFLLE--ED---PLKTAFLRRAS--VY--E-VEF------K-----------------DV------------EE------V-------NVEEVLREVDEDRRRVREAWKH--
>RLG59806.1 reverse gyrase, partial [Candidatus Hydrothermarchaeota archaeon]
-------------------------------------------------------------------------MKIR---------------------------------------------------------------------------------------AIYKNTCPNCNSDISD-LRLRKGLPCSNC---------------------------------YRFQDH----YC------EHA-------K-SLKKLK-SYC--EFKDELENFISFFKSKI-A-EPWSLQIAWAKRVLLGRSFALLAPTGVGKTTFGIVVAQYL-K-------------G----KRYLILPSRLLVEQI---AERLN----------------------------------------ALAYH-SKM--KKKERE-EVKERIKK-GDF-E------ILVTTSMFLWKNFDI-L-R---RN----TFDFIFVDDVDSVLKR-DKNVDRLLYLLGYSQ--EELRLA-------LELIKLK----------------------------------S----NWEK-------N-----------KAKIEELEK-KI--RK-NK--G-LL--LVSSAT--TRVKSK-RVKLFRELLDFEVGATFL-TLRNIEDIYL----KE-----------------------GDII------------ELIRKLG-S---GCLLFTLS---KEE-------VGEWVRKLNLA-KIKAVSY-----------ENFEKFEQGKASVAVGIASVKNPLARGIDLPHLIRYVIFTGVPKFKLRL-------SV-E--DK-SKLFPLLVNLREL-M-EKE------EREKV-DRFIYQLK-GK------------------------------------------------------KA-NIEEIKKFLEQKLADKSFIDKIKRS-KEI---TLA-YE-------NNE--LSI-IIADVASYIQASGRCSRLFPGGISKGASFLFV--DD--EKAFKSLKKRIR--WYYED-IDF------K-----------------PI------------EN------I-------NIEELMEEIDKDREKIRKC-RE-G