diff --git a/packages/workbox-webpack-plugin/src/inject-manifest.js b/packages/workbox-webpack-plugin/src/inject-manifest.js
index 7565feeab..fee1af5c9 100644
--- a/packages/workbox-webpack-plugin/src/inject-manifest.js
+++ b/packages/workbox-webpack-plugin/src/inject-manifest.js
@@ -177,13 +177,18 @@ class InjectManifest {
     const childCompiler = compilation.createChildCompiler(
         this.constructor.name,
         outputOptions,
-        this.config.webpackCompilationPlugins,
     );
 
     childCompiler.context = parentCompiler.context;
     childCompiler.inputFileSystem = parentCompiler.inputFileSystem;
     childCompiler.outputFileSystem = parentCompiler.outputFileSystem;
 
+    if (Array.isArray(this.config.webpackCompilationPlugins)) {
+      for (const plugin of this.config.webpackCompilationPlugins) {
+        plugin.apply(childCompiler);
+      }
+    }
+
     new SingleEntryPlugin(
         parentCompiler.context,
         this.config.swSrc,
diff --git a/test/workbox-webpack-plugin/node/inject-manifest.js b/test/workbox-webpack-plugin/node/inject-manifest.js
index 06185a550..e23dc32f2 100644
--- a/test/workbox-webpack-plugin/node/inject-manifest.js
+++ b/test/workbox-webpack-plugin/node/inject-manifest.js
@@ -1239,6 +1239,57 @@ describe(`[workbox-webpack-plugin] InjectManifest (End to End)`, function() {
       });
     });
 
+    it(`should use webpackCompilationPlugins with DefinePlugin`, function(done) {
+      const prefix = 'replaced-by-define-plugin';
+      const swSrc = upath.join(__dirname, '..', 'static', 'sw-src-define-plugin.js');
+      const outputDir = tempy.directory();
+      const config = {
+        mode: 'production',
+        entry: upath.join(SRC_DIR, WEBPACK_ENTRY_FILENAME),
+        output: {
+          filename: '[name].[hash:20].js',
+          path: outputDir,
+        },
+        plugins: [
+          new InjectManifest({
+            swSrc,
+            swDest: 'service-worker.js',
+            webpackCompilationPlugins: [
+              new webpack.DefinePlugin({
+                __PREFIX__: JSON.stringify(prefix),
+              }),
+            ],
+          }),
+        ],
+      };
+
+      const compiler = webpack(config);
+      compiler.run(async (webpackError, stats) => {
+        const swFile = upath.join(outputDir, 'service-worker.js');
+        try {
+          webpackBuildCheck(webpackError, stats);
+
+          const files = await globby('**', {cwd: outputDir});
+          expect(files).to.have.length(2);
+          await validateServiceWorkerRuntime({
+            swFile,
+            entryPoint: 'injectManifest',
+            expectedMethodCalls: {
+              setCacheNameDetails: [[{prefix}]],
+              precacheAndRoute: [[[{
+                revision: /^[0-9a-f]{32}$/,
+                url: /^main\.[0-9a-f]{20}\.js$/,
+              }], {}]],
+            },
+          });
+
+          done();
+        } catch (error) {
+          done(error);
+        }
+      });
+    });
+
     it(`should use manifestTransforms`, function(done) {
       const outputDir = tempy.directory();
       const warningMessage = 'test warning';
diff --git a/test/workbox-webpack-plugin/static/sw-src-define-plugin.js b/test/workbox-webpack-plugin/static/sw-src-define-plugin.js
new file mode 100644
index 000000000..4063cbfde
--- /dev/null
+++ b/test/workbox-webpack-plugin/static/sw-src-define-plugin.js
@@ -0,0 +1,12 @@
+/*
+  Copyright 2020 Google LLC
+  Use of this source code is governed by an MIT-style
+  license that can be found in the LICENSE file or at
+  https://opensource.org/licenses/MIT.
+*/
+
+// This is used to validate the DefinePlugin's replacement.
+const prefix = __PREFIX__;
+workbox.core.setCacheNameDetails({prefix});
+
+workbox.precaching.precacheAndRoute(self.__WB_MANIFEST, {});