Differential accessibility analysis adjusted for copy-number changes

[northerngasc]

Hi,

I use ArchR to analyze cancer data and identify differentially accessible peaks (DAPs) in each tumor compared to normal cells.
A limitation is that tumor cells harbor copy-number alterations (CNAs) that affect the expected number of reads per peak.
I have matched whole genome sequencing data so I know the absolute copy-number at each ATAC peak.
Is there a way to give this information to ArchR to identify peaks with differential accessibility while adjusting for CNAs?

Thanks a lot!
Eric