diff --git a/Formula/u/uv.rb b/Formula/u/uv.rb
index c92f3dea371c..610146bf748b 100644
--- a/Formula/u/uv.rb
+++ b/Formula/u/uv.rb
@@ -1,19 +1,19 @@
 class Uv < Formula
   desc "Extremely fast Python package installer and resolver, written in Rust"
   homepage "https://github.com/astral-sh/uv"
-  url "https://github.com/astral-sh/uv/archive/refs/tags/0.4.5.tar.gz"
-  sha256 "8a58f1059d31b1caabd8e90ca51833d4a6894def0b958247a9f50bcfbb02bf08"
+  url "https://github.com/astral-sh/uv/archive/refs/tags/0.4.6.tar.gz"
+  sha256 "d89a43e32851bd5df7c6c78d77718a68b75b61dccebee76efb717ae9c3349f63"
   license any_of: ["Apache-2.0", "MIT"]
   head "https://github.com/astral-sh/uv.git", branch: "main"
 
   bottle do
-    sha256 cellar: :any_skip_relocation, arm64_sonoma:   "4ac4f3b8d5ec2ef57cc504eac2328bd54361a1841077ebe1e66d664d3e970c4c"
-    sha256 cellar: :any_skip_relocation, arm64_ventura:  "9e3b44dda980a653a56061664d8fa7a277054144115535ea700a0db9400ec3c9"
-    sha256 cellar: :any_skip_relocation, arm64_monterey: "b44edbc74436504a7fc80a94a063bd2221d2ddeeaef900ad7ab4c77c4eb12ba0"
-    sha256 cellar: :any_skip_relocation, sonoma:         "a8cf2fd540d54d4e1558beaf94414235d52ad2113b277371a4c80739eed789d0"
-    sha256 cellar: :any_skip_relocation, ventura:        "69c0da1d8243533c0c4207f22e696b8e7730fcd7e2e73358a5b8cb31456c76b9"
-    sha256 cellar: :any_skip_relocation, monterey:       "eb45aa7cb5cd31c57dbf948fdd43dc61175f51f205291fe6e66de36e2eb70dea"
-    sha256 cellar: :any_skip_relocation, x86_64_linux:   "386b4ff75fd71dcd66a2888dc9425a7864abf82e14201508262d627d84976e72"
+    sha256 cellar: :any_skip_relocation, arm64_sonoma:   "3432ea1281428eb20f52aa47d021b7da42a6401238f962b4eb043a9b461b87b2"
+    sha256 cellar: :any_skip_relocation, arm64_ventura:  "144070cd95db0252cddb22fb1fc7f9d0bb11a6f0669569c6c0c5e4a0422aabdc"
+    sha256 cellar: :any_skip_relocation, arm64_monterey: "09fd7c37a51f2844c7b8142b94313a63c3e89232ec1a042d3619918df306b137"
+    sha256 cellar: :any_skip_relocation, sonoma:         "84dbf851518bf5e7e9ddc4700859a0443d2c9b594a22405bf045c34502c4ca03"
+    sha256 cellar: :any_skip_relocation, ventura:        "de45688178d174ec77d59e103a0f94796a994bb5a7607554fbb04566e42e7f33"
+    sha256 cellar: :any_skip_relocation, monterey:       "6f2c31b58864112fb6f7977bf79c799efe3f1837393a543fa556457fd18239da"
+    sha256 cellar: :any_skip_relocation, x86_64_linux:   "402663bc3a4d0a7cd8a96dc83cec6395436bc82e76aaeb2ac1326b9e31020743"
   end
 
   depends_on "pkg-config" => :build