diff --git a/Modules/Core/Common/include/itkVariableLengthVector.h b/Modules/Core/Common/include/itkVariableLengthVector.h
index bf4d709131a..636a83e048b 100644
--- a/Modules/Core/Common/include/itkVariableLengthVector.h
+++ b/Modules/Core/Common/include/itkVariableLengthVector.h
@@ -20,9 +20,9 @@
 
 #include <cassert>
 #include <algorithm>
+#include <type_traits>
 #include "itkNumericTraits.h"
 #include "itkMetaProgrammingLibrary.h"
-#include "itkEnableIf.h"
 #include "itkIsBaseOf.h"
 #include "itkIsNumber.h"
 #include "itkPromoteType.h"
@@ -1052,7 +1052,7 @@ struct GetType
  * \sa \c VariableLengthVectorExpression
  */
 template <typename TExpr1, typename TExpr2>
-inline typename mpl::EnableIf<mpl::And<mpl::IsArray<TExpr1>, mpl::IsArray<TExpr2>>, unsigned int>::Type
+inline std::enable_if_t<mpl::And<mpl::IsArray<TExpr1>, mpl::IsArray<TExpr2>>::Value, unsigned int>
 GetSize(TExpr1 const & lhs, TExpr2 const & rhs)
 {
   (void)rhs;
@@ -1071,7 +1071,7 @@ GetSize(TExpr1 const & lhs, TExpr2 const & rhs)
  * \sa \c VariableLengthVectorExpression
  */
 template <typename TExpr1, typename TExpr2>
-inline typename mpl::EnableIf<mpl::And<mpl::IsArray<TExpr1>, mpl::Not<mpl::IsArray<TExpr2>>>, unsigned int>::Type
+inline std::enable_if_t<mpl::And<mpl::IsArray<TExpr1>, mpl::Not<mpl::IsArray<TExpr2>>>::Value, unsigned int>
 GetSize(TExpr1 const & lhs, TExpr2 const & itkNotUsed(rhs))
 {
   return lhs.Size();
@@ -1087,7 +1087,7 @@ GetSize(TExpr1 const & lhs, TExpr2 const & itkNotUsed(rhs))
  * \sa \c VariableLengthVectorExpression
  */
 template <typename TExpr1, typename TExpr2>
-inline typename mpl::EnableIf<mpl::And<mpl::IsArray<TExpr2>, mpl::Not<mpl::IsArray<TExpr1>>>, unsigned int>::Type
+inline std::enable_if_t<mpl::And<mpl::IsArray<TExpr2>, mpl::Not<mpl::IsArray<TExpr1>>>::Value, unsigned int>
 GetSize(TExpr1 const & itkNotUsed(lhs), TExpr2 const & rhs)
 {
   return rhs.Size();
@@ -1261,8 +1261,8 @@ struct VariableLengthVectorExpression
  * \sa \c mpl::IsArray<> to know the exact array types recognized as \em array by this traits
  */
 template <typename TExpr1, typename TExpr2>
-inline typename mpl::EnableIf<Details::op::CanBeAddedOrSubtracted<TExpr1, TExpr2>,
-                              VariableLengthVectorExpression<TExpr1, TExpr2, Details::op::Plus>>::Type
+inline std::enable_if_t<Details::op::CanBeAddedOrSubtracted<TExpr1, TExpr2>::Value,
+                        VariableLengthVectorExpression<TExpr1, TExpr2, Details::op::Plus>>
 operator+(TExpr1 const & lhs, TExpr2 const & rhs)
 {
   return VariableLengthVectorExpression<TExpr1, TExpr2, Details::op::Plus>(lhs, rhs);
@@ -1278,8 +1278,8 @@ operator+(TExpr1 const & lhs, TExpr2 const & rhs)
  * \sa \c mpl::IsArray<> to know the exact array types recognized as \em array by this traits
  */
 template <typename TExpr1, typename TExpr2>
-inline typename mpl::EnableIf<Details::op::CanBeAddedOrSubtracted<TExpr1, TExpr2>,
-                              VariableLengthVectorExpression<TExpr1, TExpr2, Details::op::Sub>>::Type
+inline std::enable_if_t<Details::op::CanBeAddedOrSubtracted<TExpr1, TExpr2>::Value,
+                        VariableLengthVectorExpression<TExpr1, TExpr2, Details::op::Sub>>
 operator-(TExpr1 const & lhs, TExpr2 const & rhs)
 {
   return VariableLengthVectorExpression<TExpr1, TExpr2, Details::op::Sub>(lhs, rhs);
@@ -1294,8 +1294,8 @@ operator-(TExpr1 const & lhs, TExpr2 const & rhs)
  * \sa \c mpl::IsArray<> to know the exact array types recognized as \em array by this traits
  */
 template <typename TExpr1, typename TExpr2>
-inline typename mpl::EnableIf<Details::op::CanBeMultiplied<TExpr1, TExpr2>,
-                              VariableLengthVectorExpression<TExpr1, TExpr2, Details::op::Mult>>::Type
+inline std::enable_if_t<Details::op::CanBeMultiplied<TExpr1, TExpr2>::Value,
+                        VariableLengthVectorExpression<TExpr1, TExpr2, Details::op::Mult>>
 operator*(TExpr1 const & lhs, TExpr2 const & rhs)
 {
   return VariableLengthVectorExpression<TExpr1, TExpr2, Details::op::Mult>(lhs, rhs);
@@ -1309,8 +1309,8 @@ operator*(TExpr1 const & lhs, TExpr2 const & rhs)
  * \sa \c mpl::IsArray<> to know the exact array types recognized as \em array by this traits
  */
 template <typename TExpr1, typename TExpr2>
-inline typename mpl::EnableIf<Details::op::CanBeDivided<TExpr1, TExpr2>,
-                              VariableLengthVectorExpression<TExpr1, TExpr2, Details::op::Div>>::Type
+inline std::enable_if_t<Details::op::CanBeDivided<TExpr1, TExpr2>::Value,
+                        VariableLengthVectorExpression<TExpr1, TExpr2, Details::op::Div>>
 operator/(TExpr1 const & lhs, TExpr2 const & rhs)
 {
   return VariableLengthVectorExpression<TExpr1, TExpr2, Details::op::Div>(lhs, rhs);
@@ -1341,7 +1341,7 @@ operator<<(std::ostream & os, VariableLengthVectorExpression<TExpr1, TExpr2, TBi
  * \relates itk::VariableLengthVectorExpression
  */
 template <typename TExpr>
-inline typename mpl::EnableIf<mpl::IsArray<TExpr>, typename TExpr::RealValueType>::Type
+inline std::enable_if_t<mpl::IsArray<TExpr>::Value, typename TExpr::RealValueType>
 GetNorm(TExpr const & v)
 {
   return static_cast<typename TExpr::RealValueType>(std::sqrt(static_cast<double>(GetSquaredNorm(v))));
@@ -1353,7 +1353,7 @@ GetNorm(TExpr const & v)
  * \relates itk::VariableLengthVectorExpression
  */
 template <typename TExpr>
-inline typename mpl::EnableIf<mpl::IsArray<TExpr>, typename TExpr::RealValueType>::Type
+inline std::enable_if_t<mpl::IsArray<TExpr>::Value, typename TExpr::RealValueType>
 GetSquaredNorm(TExpr const & v)
 {
   using RealValueType = typename TExpr::RealValueType;
diff --git a/Modules/IO/ImageBase/include/itkConvertPixelBuffer.h b/Modules/IO/ImageBase/include/itkConvertPixelBuffer.h
index 168fc4b652e..5e41f17fd57 100644
--- a/Modules/IO/ImageBase/include/itkConvertPixelBuffer.h
+++ b/Modules/IO/ImageBase/include/itkConvertPixelBuffer.h
@@ -21,7 +21,7 @@
 
 #include "itkObject.h"
 #include "itkNumericTraits.h"
-#include "itkEnableIf.h"
+#include <type_traits> // for enable_if
 
 namespace itk
 {
@@ -167,11 +167,11 @@ class ITK_TEMPLATE_EXPORT ConvertPixelBuffer
    *  world of rgb<float> or rgb<double> alpha would have to be 1.0
    */
   template <typename UComponentType>
-  static typename DisableIfC<NumericTraits<UComponentType>::IsInteger, UComponentType>::Type
+  static std::enable_if_t<!NumericTraits<UComponentType>::IsInteger, UComponentType>
   DefaultAlphaValue();
 
   template <typename UComponentType>
-  static typename EnableIfC<NumericTraits<UComponentType>::IsInteger, UComponentType>::Type
+  static std::enable_if_t<NumericTraits<UComponentType>::IsInteger, UComponentType>
   DefaultAlphaValue();
 };
 } // namespace itk
diff --git a/Modules/IO/ImageBase/include/itkConvertPixelBuffer.hxx b/Modules/IO/ImageBase/include/itkConvertPixelBuffer.hxx
index 2cd8e323b93..33b0d447893 100644
--- a/Modules/IO/ImageBase/include/itkConvertPixelBuffer.hxx
+++ b/Modules/IO/ImageBase/include/itkConvertPixelBuffer.hxx
@@ -29,7 +29,7 @@ namespace itk
 
 template <typename InputPixelType, typename OutputPixelType, typename OutputConvertTraits>
 template <typename UComponentType>
-typename DisableIfC<NumericTraits<UComponentType>::IsInteger, UComponentType>::Type
+std::enable_if_t<!NumericTraits<UComponentType>::IsInteger, UComponentType>
 ConvertPixelBuffer<InputPixelType, OutputPixelType, OutputConvertTraits>::DefaultAlphaValue()
 {
   return NumericTraits<UComponentType>::One;
@@ -37,7 +37,7 @@ ConvertPixelBuffer<InputPixelType, OutputPixelType, OutputConvertTraits>::Defaul
 
 template <typename InputPixelType, typename OutputPixelType, typename OutputConvertTraits>
 template <typename UComponentType>
-typename EnableIfC<NumericTraits<UComponentType>::IsInteger, UComponentType>::Type
+std::enable_if_t<NumericTraits<UComponentType>::IsInteger, UComponentType>
 ConvertPixelBuffer<InputPixelType, OutputPixelType, OutputConvertTraits>::DefaultAlphaValue()
 {
   return NumericTraits<UComponentType>::max();
diff --git a/Modules/IO/NIFTI/test/itkNiftiImageIOTest3.cxx b/Modules/IO/NIFTI/test/itkNiftiImageIOTest3.cxx
index b903108038e..bc97473dc47 100644
--- a/Modules/IO/NIFTI/test/itkNiftiImageIOTest3.cxx
+++ b/Modules/IO/NIFTI/test/itkNiftiImageIOTest3.cxx
@@ -17,13 +17,12 @@
  *=========================================================================*/
 
 #include "itkNiftiImageIOTest.h"
-#include "itkEnableIf.h"
+#include <type_traits> // for enable_if
 #include <limits>
 
 template <typename ScalarType>
 void
-Decrement(ScalarType & value,
-          typename itk::DisableIfC<std::numeric_limits<ScalarType>::is_signed, ScalarType>::Type * = nullptr)
+Decrement(ScalarType & value, std::enable_if_t<!std::numeric_limits<ScalarType>::is_signed, ScalarType> * = nullptr)
 {
   if (value > 1)
   {
@@ -33,8 +32,7 @@ Decrement(ScalarType & value,
 
 template <typename ScalarType>
 void
-Decrement(ScalarType & value,
-          typename itk::EnableIfC<std::numeric_limits<ScalarType>::is_signed, ScalarType>::Type * = nullptr)
+Decrement(ScalarType & value, std::enable_if_t<std::numeric_limits<ScalarType>::is_signed, ScalarType> * = nullptr)
 {
   if (value > -std::numeric_limits<ScalarType>::max() + 1)
   {