AUC calculation

[Pagdeklaver]

Hi,
im wondering how I can calculate an AUC from a dataset consisting of id-time-concentration

[VishnuEriyat]

Hi there, I'm also working on similar lines using some vancomycin data. Have you tried passing on the data csv file to "makeNCA(data)". If you make it into an object like x<- makeNCA(data) and then use write.csv(x,"drive name:/folder name/filename.csv"), it will give a NCA output.

Actually I tried this but faced another issue, the AUC thus predicted and the AUC calculated manually by trapezoid method are different. Why does it happen Im trying to find out.

[mnneely]

We have validated makeAUC against other packages that calculate it. Can you post more details with an example from one curve how your calculations differ?

[VishnuEriyat]

Hi, sorry for the late reply, herewith attached is the snipshots from

1. model file, 2. the makeNCA output, 3.the way I calculated AUC manually
   
   
   

[mnneely]

If you could post the excerpt from the data as a text file or paste the times and concentrations, that would allow us to copy them. Thanks.

[VishnuEriyat]

Will this suffice

vanco data.txt