diff --git a/README.md b/README.md
index 5434bb25f6..1810ca2f19 100644
--- a/README.md
+++ b/README.md
@@ -87,6 +87,45 @@ docker run --gpus all \
 1. Copy the [compose.yml](./docker/compose.yaml) to your local machine
 2. Execute the command `docker compose up -d` in your terminal.
 
+### Method 5: Run on Kubernetes or Clouds with SkyPilot
+
+To deploy on Kubernetes or clouds, you can use [SkyPilot](https://github.com/skypilot-org/skypilot).
+
+1. Install SkyPilot and set up Kubernetes cluster or cloud access: see [SkyPilot's documentation](https://skypilot.readthedocs.io/en/latest/getting-started/installation.html).
+2. Deploy on your own infra with a single command and get the HTTP API endpoint:
+<details>
+<summary>SkyPilot YAML: <code>sglang.yaml</code></summary>
+
+```yaml
+# sglang.yaml
+envs:
+  HF_TOKEN: null
+
+resources:
+  image_id: docker:lmsysorg/sglang:latest
+  accelerators: A100
+  ports: 30000
+
+run: |
+  conda deactivate
+  python3 -m sglang.launch_server \
+    --model-path meta-llama/Meta-Llama-3.1-8B-Instruct \
+    --host 0.0.0.0 \
+    --port 30000
+```
+
+</details>
+
+```bash
+# Deploy on any cloud or Kubernetes cluster. Use --cloud <cloud> to select a specific cloud provider.
+HF_TOKEN=<secret> sky launch -c sglang --env HF_TOKEN sglang.yaml
+
+# Get the HTTP API endpoint
+sky status --endpoint 30000 sglang
+```
+
+
+
 ### Common Notes
 - [FlashInfer](https://github.com/flashinfer-ai/flashinfer) is currently one of the dependencies that must be installed for SGLang. If you are using NVIDIA GPU devices below sm80, such as T4, you can't use SGLang for the time being. We expect to resolve this issue soon, so please stay tuned. If you encounter any FlashInfer-related issues on sm80+ devices (e.g., A100, L40S, H100), consider using Triton's kernel by `--disable-flashinfer --disable-flashinfer-sampling` and raise a issue.
 - If you only need to use the OpenAI backend, you can avoid installing other dependencies by using `pip install "sglang[openai]"`.