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Spike Propagation through the Dorsal Root Ganglion

Two versions of the model of an un-myelinated, C-fiber sensory neuron from:

Sundt D, Gamper N, and Jaffe DB. Spike propagation through the dorsal root ganglia in an unmyelinated sensory neuron: a modeling study. J Neurophysiol. 2015 Dec 1;114(6):3140-53. doi:10.1152/jn.00226.2015

The two versions, located in separate folders, generate Figures 5d and 8c. Figure5d varies M-channel density and illustrates where the reflecting spike generated. Figure8c illustrates the effect of the Na/K pump on membrane potential and spike failure at the T-junction.

Running the simulations

Here is a sketch of how to run the programs. There is more help available at https://modeldb.science/NEURON_DwnldGuide.

  1. Compile the ".mod files" within the mods folder.

  2. For each version of the model, compile the mod files within the mod folder (Figure5d/mods & Figure8c/mods).

  3. For either version (Figure5d.hoc or Figure8c.hoc), run the simulation using the "special" executable.

  4. Data output, Fig5doutput.dat or Fig8coutput.dat, can be viewed using the python scripts provided (Plot5d.py and Plot8c.py, respectively). You should see the following graphs:

figure 5d

figure 8c

Changelog

2024-10-01 Updated links and converted readme to markdown