diff --git a/pkgs/development/interpreters/python/hooks/default.nix b/pkgs/development/interpreters/python/hooks/default.nix
index ba51c43822d470f..bb211014b3aba3b 100644
--- a/pkgs/development/interpreters/python/hooks/default.nix
+++ b/pkgs/development/interpreters/python/hooks/default.nix
@@ -188,7 +188,9 @@ in {
         name = "setuptools-rust-setup-hook";
         propagatedBuildInputs = [ setuptools-rust ];
         substitutions = {
+          pyIncludeDir = "${python}/include/${python.libPrefix}";
           pyLibDir = "${python}/lib/${python.libPrefix}";
+          pyBin = python.interpreter;
           cargoBuildTarget = rust.toRustTargetSpec stdenv.hostPlatform;
           cargoLinkerVar = lib.toUpper (
               builtins.replaceStrings ["-"] ["_"] (
diff --git a/pkgs/development/interpreters/python/hooks/setuptools-rust-hook.sh b/pkgs/development/interpreters/python/hooks/setuptools-rust-hook.sh
index 917c19ef9b31ba5..c2cda07d9bd1d81 100644
--- a/pkgs/development/interpreters/python/hooks/setuptools-rust-hook.sh
+++ b/pkgs/development/interpreters/python/hooks/setuptools-rust-hook.sh
@@ -7,7 +7,9 @@ setuptoolsRustSetup() {
         exit 1
     fi
 
-    export PYO3_CROSS_LIB_DIR="@pyLibDir@"
+    export PYO3_CROSS_INCLUDE_DIR="@pyIncludeDir@";
+    export PYO3_CROSS_LIB_DIR="@pyLibDir@";
+    export PYO3_PYTHON="@pyBin@";
     export CARGO_BUILD_TARGET=@cargoBuildTarget@
     # TODO theoretically setting linker should not be required because it is
     # already set in pkgs/build-support/rust/hooks/default.nix but build fails