diff --git a/pkgs/development/libraries/qt-6/hooks/qtbase-setup-hook.sh b/pkgs/development/libraries/qt-6/hooks/qtbase-setup-hook.sh
index 9bc68e6cd3d61..9f1bba4e63d2f 100644
--- a/pkgs/development/libraries/qt-6/hooks/qtbase-setup-hook.sh
+++ b/pkgs/development/libraries/qt-6/hooks/qtbase-setup-hook.sh
@@ -1,3 +1,13 @@
+if [[ "x$stdenv" != "x@qtbase_stdenv@" ]]; then
+  echo "skipping qtbase-setup-hook.sh because of mismatch:"
+  echo "  stdenv of current derivation: $stdenv"
+  echo "  stdenv of qtbase.dev dependency: @qtbase_stdenv@"
+  echo "    qtbase = @dev@"
+  return
+fi
+
+echo "running qtbase-setup-hook.sh with hostOffset=$hostOffset targetOffset=$targetOffset: @out@"
+
 if [[ -n "${__nix_qtbase-}" ]]; then
     # Throw an error if a different version of Qt was already set up.
     if [[ "$__nix_qtbase" != "@out@" ]]; then
diff --git a/pkgs/development/libraries/qt-6/modules/qtbase.nix b/pkgs/development/libraries/qt-6/modules/qtbase.nix
index c0a20503e64c0..912d8ff53116c 100644
--- a/pkgs/development/libraries/qt-6/modules/qtbase.nix
+++ b/pkgs/development/libraries/qt-6/modules/qtbase.nix
@@ -201,6 +201,12 @@ stdenv.mkDerivation rec {
 
   enableParallelBuilding = true;
 
+  env = lib.optionalAttrs (stdenv.buildPlatform != stdenv.hostPlatform) {
+    QT_HOST_PATH = "${pkgsBuildHost.qt6Packages.qtbase}";
+  } // {
+    qtbase_stdenv = stdenv.outPath;
+  };
+
   inherit patches;
 
   # https://bugreports.qt.io/browse/QTBUG-97568