Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Duplicate peptides in phosphoproteomics data #70

Open
LJMHiggins opened this issue Dec 17, 2024 · 0 comments
Open

Duplicate peptides in phosphoproteomics data #70

LJMHiggins opened this issue Dec 17, 2024 · 0 comments

Comments

@LJMHiggins
Copy link

Firstly, thank you for putting together this useful resource.

I have been accessing the phoshphoproteomics data for some analyses, and have found what looks like peptide duplication.

I am using cptac Version: 1.5.14

I found the duplication by running the following:

luad = cptac.Luad()
test = luad.get_phosphoproteomics("bcm")
flat_columns = ['_'.join(map(str, col)) for col in test.columns]
duplicates = pd.Series(flat_columns).duplicated()
len(pd.Series(flat_columns)[duplicates])
`
Giving 61807 duplicates.

Inspection of a specific peptide confirmed duplication:

test.loc[:, [col for col in test.columns if "SCPIKEDSFLQRYSS" in col]]

Not sure if this is present in other tumour types at this stage. Do you know why I could be seeing this?

Many thanks

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

No branches or pull requests

1 participant