diff --git a/CHANGELOG.md b/CHANGELOG.md
index d55bec9be72..d219465fe82 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -62,6 +62,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 - Use `memoffset` for computing PyCell offsets [#2450](https://github.com/PyO3/pyo3/pull/2450)
 - Fix incorrect enum names being returned by `repr` for enums renamed by `#[pyclass(name)]` [#2457](https://github.com/PyO3/pyo3/pull/2457)
 - Fix incorrect Python version cfg definition on `PyObject_CallNoArgs`[#2476](https://github.com/PyO3/pyo3/pull/2476)
+- Fix use-after-free in `PyCapsule` type. [#2481](https://github.com/PyO3/pyo3/pull/2481)
 
 ## [0.16.5] - 2022-05-15
 
diff --git a/noxfile.py b/noxfile.py
index ba81e1a0dd0..12fe0e4b293 100644
--- a/noxfile.py
+++ b/noxfile.py
@@ -1,4 +1,5 @@
 import re
+import subprocess
 import sys
 import time
 from glob import glob
@@ -199,3 +200,32 @@ def test_emscripten(session: nox.Session):
 @nox.session(name="build-guide", venv_backend="none")
 def build_guide(session: nox.Session):
     session.run("mdbook", "build", "-d", "../target/guide", "guide", *session.posargs)
+
+
+@nox.session(name="address-sanitizer", venv_backend="none")
+def address_sanitizer(session: nox.Session):
+    session.run(
+        "cargo",
+        "+nightly",
+        "test",
+        f"--target={_get_rust_target()}",
+        "--",
+        "--test-threads=1",
+        env={
+            "RUSTFLAGS": "-Zsanitizer=address",
+            "RUSTDOCFLAGS": "-Zsanitizer=address",
+            "ASAN_OPTIONS": "detect_leaks=0",
+        },
+        external=True,
+    )
+
+
+def _get_rust_target() -> str:
+    output = subprocess.check_output(["rustc", "-vV"], text=True)
+
+    for line in output.splitlines():
+        if line.startswith(_HOST_LINE_START):
+            return line[len(_HOST_LINE_START) :].strip()
+
+
+_HOST_LINE_START = "host: "
diff --git a/src/ffi/tests.rs b/src/ffi/tests.rs
index fcb93ee0792..a1789366133 100644
--- a/src/ffi/tests.rs
+++ b/src/ffi/tests.rs
@@ -48,9 +48,10 @@ fn test_utc_timezone() {
     Python::with_gil(|py| {
         let utc_timezone = unsafe {
             PyDateTime_IMPORT();
-            &*(&PyDateTime_TimeZone_UTC() as *const *mut crate::ffi::PyObject
-                as *const crate::PyObject)
+            PyDateTime_TimeZone_UTC()
         };
+        let utc_timezone =
+            unsafe { &*((&utc_timezone) as *const *mut PyObject as *const Py<PyAny>) };
         let locals = PyDict::new(py);
         locals.set_item("utc_timezone", utc_timezone).unwrap();
         py.run(
diff --git a/src/types/capsule.rs b/src/types/capsule.rs
index 8add77b4133..525b68ac2fe 100644
--- a/src/types/capsule.rs
+++ b/src/types/capsule.rs
@@ -2,7 +2,7 @@
 use crate::Python;
 use crate::{ffi, AsPyPointer, PyAny};
 use crate::{pyobject_native_type_core, PyErr, PyResult};
-use std::ffi::{c_void, CStr};
+use std::ffi::{c_void, CStr, CString};
 use std::os::raw::c_int;
 
 /// Represents a Python Capsule
@@ -100,12 +100,21 @@ impl PyCapsule {
         destructor: F,
     ) -> PyResult<&'py Self> {
         AssertNotZeroSized::assert_not_zero_sized(&value);
-        let val = Box::new(CapsuleContents { value, destructor });
+        // Take ownership of a copy of `name` so that the string is guaranteed to live as long
+        // as the capsule. PyCapsule_new purely saves the pointer in the capsule so doesn't
+        // guarantee ownership itself.
+        let name = name.to_owned();
+        let name_ptr = name.as_ptr();
+        let val = Box::new(CapsuleContents {
+            value,
+            destructor,
+            name,
+        });
 
         let cap_ptr = unsafe {
             ffi::PyCapsule_New(
                 Box::into_raw(val) as *mut c_void,
-                name.as_ptr(),
+                name_ptr,
                 Some(capsule_destructor::<T, F>),
             )
         };
@@ -221,6 +230,7 @@ impl PyCapsule {
 struct CapsuleContents<T: 'static + Send, D: FnOnce(T, *mut c_void)> {
     value: T,
     destructor: D,
+    name: CString,
 }
 
 // Wrapping ffi::PyCapsule_Destructor for a user supplied FnOnce(T) for capsule destructor
@@ -229,7 +239,9 @@ unsafe extern "C" fn capsule_destructor<T: 'static + Send, F: FnOnce(T, *mut c_v
 ) {
     let ptr = ffi::PyCapsule_GetPointer(capsule, ffi::PyCapsule_GetName(capsule));
     let ctx = ffi::PyCapsule_GetContext(capsule);
-    let CapsuleContents { value, destructor } = *Box::from_raw(ptr as *mut CapsuleContents<T, F>);
+    let CapsuleContents {
+        value, destructor, ..
+    } = *Box::from_raw(ptr as *mut CapsuleContents<T, F>);
     destructor(value, ctx)
 }