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Improve VEP #732

Merged
merged 33 commits into from
Feb 27, 2019
Merged

Improve VEP #732

merged 33 commits into from
Feb 27, 2019

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maxulysse
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@maxulysse maxulysse commented Feb 25, 2019

  • Update VEP from 95.1 to 95.2
  • Removed --database option for VEP cf: VEP docs
  • Add tabix indexed cache for VEP
  • Reduce number of CPUs for RunVEP to 4 cf: VEP docs
  • VEP cache has now fasta files for --HGVS
  • Merge buildContainers.nf and buildReferences.nf in build.nf
  • New DownloadCADD process to download CADD files
  • Add cadd_WG_SNVs, cadd_WG_SNVs_tbi, cadd_InDels, cadd_InDels_tbi and cadd_cache params
  • Use cadd_cache param for optional use of CADD VEP plugin in annotate.nf
  • Specify values for cadd_WG_SNVs, cadd_WG_SNVs_tbi, cadd_InDels, cadd_InDels_tbi and cadd_cache params in munin.conf file
  • Update documentation

PR checklist

  • PR is made against dev branch
  • This comment contains a description of changes (with reason)
  • Ensure the test suite passes (./scripts/test.sh -p docker -t ALL).
  • Documentation in docs is updated
  • CHANGELOG.md is updated

@maxulysse
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@KochTobi
Regarding your VEP issue, this is best I can do without going deeper and using intervals for the VCF files as well.
On my test the running time was reduced from 2h50 to ~ 1h40, mainly by tabix indexing the VEP cache directory

@szilvajuhos
We can now use the VEP CADD plugin, I added some specific params in the munin config file, and the files are already there.
So you just need to add --cadd_cache to enable it.
I'll look into the other plugins Teresita wants to use

@maxulysse maxulysse mentioned this pull request Feb 27, 2019
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@maxulysse maxulysse merged commit 2ddd8b2 into SciLifeLab:dev Feb 27, 2019
@maxulysse maxulysse deleted the VEP branch February 27, 2019 16:04
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