diff --git a/tests/models/test_patch_predictor.py b/tests/models/test_patch_predictor.py
index 6c04c6b68..5fd930138 100644
--- a/tests/models/test_patch_predictor.py
+++ b/tests/models/test_patch_predictor.py
@@ -1239,7 +1239,7 @@ def test_patch_predictor_torch_compile(
     sample_patch2: Path,
     tmp_path: Path,
 ) -> None:
-    """Test torch.compile functionality.
+    """Test PatchPredictor with with torch.compile functionality.
 
     Args:
         sample_patch1 (Path): Path to sample patch 1.
@@ -1247,10 +1247,8 @@ def test_patch_predictor_torch_compile(
         tmp_path (Path): Path to temporary directory.
 
     """
-    torch_compile_enabled = rcParam["enable_torch_compile"]
+    torch_compile_mode = rcParam["torch_compile_mode"]
     torch._dynamo.reset()
-    rcParam["enable_torch_compile"] = True
-    # Test torch.compile with default mode
     rcParam["torch_compile_mode"] = "default"
     _, compile_time = timed(
         test_patch_predictor_api,
@@ -1278,4 +1276,4 @@ def test_patch_predictor_torch_compile(
     )
     logger.info("torch.compile max-autotune mode: %s", compile_time)
     torch._dynamo.reset()
-    rcParam["enable_torch_compile"] = torch_compile_enabled
+    rcParam["torch_compile_mode"] = torch_compile_mode
diff --git a/tests/test_utils.py b/tests/test_utils.py
index cf76028aa..d35ae31e5 100644
--- a/tests/test_utils.py
+++ b/tests/test_utils.py
@@ -19,7 +19,7 @@
 from shapely.geometry import Polygon
 
 from tests.test_annotation_stores import cell_polygon
-from tiatoolbox import utils
+from tiatoolbox import rcParam, utils
 from tiatoolbox.annotation.storage import SQLiteStore
 from tiatoolbox.models.architecture import fetch_pretrained_weights
 from tiatoolbox.models.architecture.utils import compile_model
@@ -1825,15 +1825,35 @@ def test_patch_pred_store_persist_ext(tmp_path: pytest.TempPathFactory) -> None:
 
 def test_torch_compile_already_compiled() -> None:
     """Test that torch_compile does not recompile a model that is already compiled."""
-    # Create a simple model
+    torch_compile_modes = [
+        "default",
+        "reduce-overhead",
+        "max-autotune",
+        "max-autotune-no-cudagraphs",
+    ]
+    current_torch_compile_mode = rcParam["torch_compile_mode"]
+    model = torch.nn.Sequential(torch.nn.Linear(10, 10), torch.nn.Linear(10, 10))
+
+    for mode in torch_compile_modes:
+        torch._dynamo.reset()
+        rcParam["torch_compile_mode"] = mode
+        compiled_model = compile_model(model, mode=mode)
+        recompiled_model = compile_model(compiled_model, mode=mode)
+        assert compiled_model == recompiled_model
+
+    torch._dynamo.reset()
+    rcParam["torch_compile_mode"] = current_torch_compile_mode
+
+
+def test_torch_compile_disable() -> None:
+    """Test torch_compile's disable mode."""
     model = torch.nn.Sequential(torch.nn.Linear(10, 10), torch.nn.Linear(10, 10))
+    compiled_model = compile_model(model, mode="disable")
+    assert model == compiled_model
 
-    # Compile the model
-    compiled_model = compile_model(model)
 
-    # Compile the model again
-    recompiled_model = compile_model(compiled_model)
+def test_torch_compile_compatibility() -> None:
+    """Test if torch-compile compatibility is checked correctly."""
+    from tiatoolbox.models.architecture.utils import is_torch_compile_compatible
 
-    # Check that the recompiled model
-    # is the same as the original compiled model
-    assert compiled_model == recompiled_model
+    assert isinstance(is_torch_compile_compatible(), bool)
diff --git a/tests/test_wsi_registration.py b/tests/test_wsi_registration.py
index 79abd3855..4e0f07366 100644
--- a/tests/test_wsi_registration.py
+++ b/tests/test_wsi_registration.py
@@ -5,7 +5,10 @@
 import cv2
 import numpy as np
 import pytest
+import torch
 
+from tests.conftest import timed
+from tiatoolbox import logger, rcParam
 from tiatoolbox.tools.registration.wsi_registration import (
     AffineWSITransformer,
     DFBRegister,
@@ -576,3 +579,70 @@ def test_affine_wsi_transformer(sample_ome_tiff: Path) -> None:
         expected = cv2.rotate(expected, cv2.ROTATE_90_CLOCKWISE)
 
         assert np.sum(expected - output) == 0
+
+
+def test_dfbr_feature_extractor_torch_compile(dfbr_features: Path) -> None:
+    """Test DFBRFeatureExtractor with torch.compile functionality.
+
+    Args:
+        dfbr_features (Path): Path to the expected features.
+
+    """
+
+    def _extract_features() -> tuple:
+        dfbr = DFBRegister()
+        fixed_img = np.repeat(
+            np.expand_dims(
+                np.repeat(
+                    np.expand_dims(np.arange(0, 64, 1, dtype=np.uint8), axis=1),
+                    64,
+                    axis=1,
+                ),
+                axis=2,
+            ),
+            3,
+            axis=2,
+        )
+        output = dfbr.extract_features(fixed_img, fixed_img)
+        pool3_feat = output["block3_pool"][0, :].detach().numpy()
+        pool4_feat = output["block4_pool"][0, :].detach().numpy()
+        pool5_feat = output["block5_pool"][0, :].detach().numpy()
+
+        return pool3_feat, pool4_feat, pool5_feat
+
+    torch_compile_mode = rcParam["torch_compile_mode"]
+    torch._dynamo.reset()
+    rcParam["torch_compile_mode"] = "default"
+    (pool3_feat, pool4_feat, pool5_feat), compile_time = timed(_extract_features)
+    _pool3_feat, _pool4_feat, _pool5_feat = np.load(
+        str(dfbr_features),
+        allow_pickle=True,
+    )
+    assert np.mean(np.abs(pool3_feat - _pool3_feat)) < 1.0e-4
+    assert np.mean(np.abs(pool4_feat - _pool4_feat)) < 1.0e-4
+    assert np.mean(np.abs(pool5_feat - _pool5_feat)) < 1.0e-4
+    logger.info("torch.compile default mode: %s", compile_time)
+    torch._dynamo.reset()
+    rcParam["torch_compile_mode"] = "reduce-overhead"
+    (pool3_feat, pool4_feat, pool5_feat), compile_time = timed(_extract_features)
+    _pool3_feat, _pool4_feat, _pool5_feat = np.load(
+        str(dfbr_features),
+        allow_pickle=True,
+    )
+    assert np.mean(np.abs(pool3_feat - _pool3_feat)) < 1.0e-4
+    assert np.mean(np.abs(pool4_feat - _pool4_feat)) < 1.0e-4
+    assert np.mean(np.abs(pool5_feat - _pool5_feat)) < 1.0e-4
+    logger.info("torch.compile reduce-overhead mode: %s", compile_time)
+    torch._dynamo.reset()
+    rcParam["torch_compile_mode"] = "max-autotune"
+    (pool3_feat, pool4_feat, pool5_feat), compile_time = timed(_extract_features)
+    _pool3_feat, _pool4_feat, _pool5_feat = np.load(
+        str(dfbr_features),
+        allow_pickle=True,
+    )
+    assert np.mean(np.abs(pool3_feat - _pool3_feat)) < 1.0e-4
+    assert np.mean(np.abs(pool4_feat - _pool4_feat)) < 1.0e-4
+    assert np.mean(np.abs(pool5_feat - _pool5_feat)) < 1.0e-4
+    logger.info("torch.compile max-autotune mode: %s", compile_time)
+    torch._dynamo.reset()
+    rcParam["torch_compile_mode"] = torch_compile_mode
diff --git a/tiatoolbox/__init__.py b/tiatoolbox/__init__.py
index d82f785b5..80ad1b4ff 100644
--- a/tiatoolbox/__init__.py
+++ b/tiatoolbox/__init__.py
@@ -73,7 +73,6 @@ class _RcParam(TypedDict):
 
     TIATOOLBOX_HOME: Path
     pretrained_model_info: dict[str, dict]
-    enable_torch_compile: bool
     torch_compile_mode: str
 
 
@@ -104,11 +103,9 @@ def read_registry_files(path_to_registry: str | Path) -> dict:
     "pretrained_model_info": read_registry_files(
         "data/pretrained_model.yaml",
     ),  # Load a dictionary of sample files data (names and urls)
-    "enable_torch_compile": False,
-    # Disable `torch-compile`` by default
     "torch_compile_mode": "default",
-    # Set ``torch-compile`` mode to ``default`` by default
-    # Options: “default”, “reduce-overhead”, “max-autotune”
+    # Set `torch-compile` mode to `default`
+    # Options: `disable`, `default`, `reduce-overhead`, `max-autotune`
     # or “max-autotune-no-cudagraphs”
 }
 
diff --git a/tiatoolbox/models/architecture/utils.py b/tiatoolbox/models/architecture/utils.py
index 94f970df8..2150c31a1 100644
--- a/tiatoolbox/models/architecture/utils.py
+++ b/tiatoolbox/models/architecture/utils.py
@@ -12,11 +12,41 @@
 from tiatoolbox import logger
 
 
+def is_torch_compile_compatible() -> bool:
+    """Check if the current GPU is compatible with torch-compile.
+
+    Returns:
+        bool:
+            True if the GPU is compatible with torch-compile, False
+            otherwise.
+
+    """
+    if torch.cuda.is_available():  # pragma: no cover
+        device_cap = torch.cuda.get_device_capability()
+        if device_cap not in ((7, 0), (8, 0), (9, 0)):
+            logger.warning(
+                "GPU is not compatible with torch.compile. "
+                "Compatible GPUs include NVIDIA V100, A100, and H100. "
+                "Speedup numbers may be lower than expected.",
+                stacklevel=2,
+            )
+            return False
+    else:
+        logger.warning(
+            "No GPU detected or cuda not installed, "
+            "torch.compile is only supported on selected NVIDIA GPUs. "
+            "Speedup numbers may be lower than expected.",
+            stacklevel=2,
+        )
+        return False
+
+    return True  # pragma: no cover
+
+
 def compile_model(
     model: nn.Module | None = None,
     *,
     mode: str = "default",
-    disable: bool = False,
 ) -> Callable:
     """A decorator to compile a model using torch-compile.
 
@@ -25,19 +55,20 @@ def compile_model(
             Model to be compiled.
         mode (str):
             Mode to be used for torch-compile. Available modes are
-            `default`, `reduce-overhead`, `max-autotune`, and
+            `disable`, `default`, `reduce-overhead`, `max-autotune`, and
             `max-autotune-no-cudagraphs`.
-        disable (bool):
-            If True, torch-compile will be disabled.
 
     Returns:
         Callable:
             Compiled model.
 
     """
-    if disable:
+    if mode == "disable":
         return model
 
+    # Check if GPU is compatible with torch.compile
+    is_torch_compile_compatible()
+
     # This check will be removed when torch.compile is supported in Python 3.12+
     if sys.version_info >= (3, 12):  # pragma: no cover
         logger.warning(
@@ -54,7 +85,7 @@ def compile_model(
         )
         return model
 
-    return torch.compile(model, mode=mode, disable=disable)
+    return torch.compile(model, mode=mode)
 
 
 def centre_crop(
diff --git a/tiatoolbox/models/engine/patch_predictor.py b/tiatoolbox/models/engine/patch_predictor.py
index 2aede1393..da4420cb0 100644
--- a/tiatoolbox/models/engine/patch_predictor.py
+++ b/tiatoolbox/models/engine/patch_predictor.py
@@ -255,7 +255,6 @@ def __init__(
             compile_model(  # for runtime, such as after wrapping with nn.DataParallel
                 model,
                 mode=rcParam["torch_compile_mode"],
-                disable=not rcParam["enable_torch_compile"],
             )
         )
         self.pretrained_model = pretrained_model
diff --git a/tiatoolbox/tools/registration/wsi_registration.py b/tiatoolbox/tools/registration/wsi_registration.py
index 74d6a8f16..74e35ffa5 100644
--- a/tiatoolbox/tools/registration/wsi_registration.py
+++ b/tiatoolbox/tools/registration/wsi_registration.py
@@ -16,7 +16,8 @@
 from skimage.util import img_as_float
 from torchvision.models import VGG16_Weights
 
-from tiatoolbox import logger
+from tiatoolbox import logger, rcParam
+from tiatoolbox.models.architecture.utils import compile_model
 from tiatoolbox.tools.patchextraction import PatchExtractor
 from tiatoolbox.utils.metrics import dice
 from tiatoolbox.utils.transforms import imresize
@@ -338,8 +339,9 @@ def __init__(self: torch.nn.Module) -> None:
         output_layers_id: list[str] = ["16", "23", "30"]
         output_layers_key: list[str] = ["block3_pool", "block4_pool", "block5_pool"]
         self.features: dict = dict.fromkeys(output_layers_key, None)
-        self.pretrained: torch.nn.Sequential = torchvision.models.vgg16(
-            weights=VGG16_Weights.IMAGENET1K_V1,
+        self.pretrained: torch.nn.Sequential = compile_model(
+            torchvision.models.vgg16(weights=VGG16_Weights.IMAGENET1K_V1),
+            mode=rcParam["torch_compile_mode"],
         ).features
         self.f_hooks = [
             getattr(self.pretrained, layer).register_forward_hook(