diff --git a/ci/deps/actions-310.yaml b/ci/deps/actions-310.yaml
index ea2336ae78f81..a3e44e6373145 100644
--- a/ci/deps/actions-310.yaml
+++ b/ci/deps/actions-310.yaml
@@ -24,8 +24,6 @@ dependencies:
 
   # optional dependencies
   - beautifulsoup4>=4.11.2
-  # https://github.com/conda-forge/pytables-feedstock/issues/97
-  - c-blosc2=2.13.2
   - blosc>=1.21.3
   - bottleneck>=1.3.6
   - fastparquet>=2022.12.0
diff --git a/ci/deps/actions-311-downstream_compat.yaml b/ci/deps/actions-311-downstream_compat.yaml
index 8f84a53b58610..d6bf9ec7843de 100644
--- a/ci/deps/actions-311-downstream_compat.yaml
+++ b/ci/deps/actions-311-downstream_compat.yaml
@@ -26,8 +26,6 @@ dependencies:
 
   # optional dependencies
   - beautifulsoup4>=4.11.2
-  # https://github.com/conda-forge/pytables-feedstock/issues/97
-  - c-blosc2=2.13.2
   - blosc>=1.21.3
   - bottleneck>=1.3.6
   - fastparquet>=2022.12.0
diff --git a/ci/deps/actions-311.yaml b/ci/deps/actions-311.yaml
index 51a246ce73a11..95cd1a4d46ef4 100644
--- a/ci/deps/actions-311.yaml
+++ b/ci/deps/actions-311.yaml
@@ -24,8 +24,6 @@ dependencies:
 
   # optional dependencies
   - beautifulsoup4>=4.11.2
-  # https://github.com/conda-forge/pytables-feedstock/issues/97
-  - c-blosc2=2.13.2
   - blosc>=1.21.3
   - bottleneck>=1.3.6
   - fastparquet>=2022.12.0
diff --git a/ci/deps/actions-312.yaml b/ci/deps/actions-312.yaml
index 7d2b9c39d2fe3..a442ed6feeb5d 100644
--- a/ci/deps/actions-312.yaml
+++ b/ci/deps/actions-312.yaml
@@ -24,8 +24,6 @@ dependencies:
 
   # optional dependencies
   - beautifulsoup4>=4.11.2
-  # https://github.com/conda-forge/pytables-feedstock/issues/97
-  - c-blosc2=2.13.2
   - blosc>=1.21.3
   - bottleneck>=1.3.6
   - fastparquet>=2022.12.0
diff --git a/ci/deps/actions-39-minimum_versions.yaml b/ci/deps/actions-39-minimum_versions.yaml
index cedf4fb9dc867..7067048c4434d 100644
--- a/ci/deps/actions-39-minimum_versions.yaml
+++ b/ci/deps/actions-39-minimum_versions.yaml
@@ -27,8 +27,6 @@ dependencies:
 
   # optional dependencies
   - beautifulsoup4=4.11.2
-  # https://github.com/conda-forge/pytables-feedstock/issues/97
-  - c-blosc2=2.13.2
   - blosc=1.21.3
   - bottleneck=1.3.6
   - fastparquet=2022.12.0
diff --git a/ci/deps/actions-39.yaml b/ci/deps/actions-39.yaml
index 85f2a74e849ee..b162a78e7f115 100644
--- a/ci/deps/actions-39.yaml
+++ b/ci/deps/actions-39.yaml
@@ -24,8 +24,6 @@ dependencies:
 
   # optional dependencies
   - beautifulsoup4>=4.11.2
-  # https://github.com/conda-forge/pytables-feedstock/issues/97
-  - c-blosc2=2.13.2
   - blosc>=1.21.3
   - bottleneck>=1.3.6
   - fastparquet>=2022.12.0
diff --git a/ci/deps/circle-310-arm64.yaml b/ci/deps/circle-310-arm64.yaml
index c018ad94e7f30..a19ffd485262d 100644
--- a/ci/deps/circle-310-arm64.yaml
+++ b/ci/deps/circle-310-arm64.yaml
@@ -25,8 +25,6 @@ dependencies:
 
   # optional dependencies
   - beautifulsoup4>=4.11.2
-  # https://github.com/conda-forge/pytables-feedstock/issues/97
-  - c-blosc2=2.13.2
   - blosc>=1.21.3
   - bottleneck>=1.3.6
   - fastparquet>=2022.12.0
diff --git a/environment.yml b/environment.yml
index aef3ce66ff352..30c078051d330 100644
--- a/environment.yml
+++ b/environment.yml
@@ -27,8 +27,6 @@ dependencies:
 
   # optional dependencies
   - beautifulsoup4>=4.11.2
-  # https://github.com/conda-forge/pytables-feedstock/issues/97
-  - c-blosc2=2.13.2
   - blosc
   - bottleneck>=1.3.6
   - fastparquet>=2022.12.0
diff --git a/scripts/generate_pip_deps_from_conda.py b/scripts/generate_pip_deps_from_conda.py
index bf38d2fa419d1..5fcf09cd073fe 100755
--- a/scripts/generate_pip_deps_from_conda.py
+++ b/scripts/generate_pip_deps_from_conda.py
@@ -23,7 +23,7 @@
     import tomli as tomllib
 import yaml
 
-EXCLUDE = {"python", "c-compiler", "cxx-compiler", "c-blosc2"}
+EXCLUDE = {"python", "c-compiler", "cxx-compiler"}
 REMAP_VERSION = {"tzdata": "2022.7"}
 CONDA_TO_PIP = {
     "pytables": "tables",
diff --git a/scripts/validate_min_versions_in_sync.py b/scripts/validate_min_versions_in_sync.py
index 62a92cdd10ebc..7dd3e96e6ec18 100755
--- a/scripts/validate_min_versions_in_sync.py
+++ b/scripts/validate_min_versions_in_sync.py
@@ -36,7 +36,7 @@
 SETUP_PATH = pathlib.Path("pyproject.toml").resolve()
 YAML_PATH = pathlib.Path("ci/deps")
 ENV_PATH = pathlib.Path("environment.yml")
-EXCLUDE_DEPS = {"tzdata", "blosc", "c-blosc2", "pandas-gbq", "pyqt", "pyqt5"}
+EXCLUDE_DEPS = {"tzdata", "blosc", "pandas-gbq", "pyqt", "pyqt5"}
 EXCLUSION_LIST = frozenset(["python=3.8[build=*_pypy]"])
 # pandas package is not available
 # in pre-commit environment
@@ -225,9 +225,6 @@ def get_versions_from_ci(content: list[str]) -> tuple[dict[str, str], dict[str,
             seen_required = True
         elif "# optional dependencies" in line:
             seen_optional = True
-        elif "#" in line:
-            # just a comment
-            continue
         elif "- pip:" in line:
             continue
         elif seen_required and line.strip():