diff --git a/docs/contributors/scripts.md b/docs/contributors/scripts.md
index 4928ec91bde64b..28a768e41599ca 100644
--- a/docs/contributors/scripts.md
+++ b/docs/contributors/scripts.md
@@ -65,3 +65,15 @@ It is recommended to use the main `wp-polyfill` script handle which takes care o
 | [Formdata Polyfill](https://www.npmjs.com/package/formdata-polyfill) | wp-polyfill-formdata| Polyfill conditionally replaces the native implementation |
 | [Node Contains Polyfill](https://polyfill.io) | wp-polyfill-node-contains |Polyfill for Node.contains |
 | [Element Closest Polyfill](https://www.npmjs.com/package/element-closest) | wp-polyfill-element-closest| Return the closest element matching a selector up the DOM tree |
+
+## Bundling and code sharing
+
+When using a JavaScript bundler like [webpack](https://webpack.js.org/), the scripts mentioned here
+can be excluded from the bundle and provided by WordPress in the form of script dependencies [(see
+`wp_enqueue_script`)][https://developer.wordpress.org/reference/functions/wp_enqueue_script/#default-scripts-included-and-registered-by-wordpress].
+
+The
+[`@wordpress/dependency-extraction-webpack-plugin`](https://github.com/WordPress/gutenberg/tree/master/packages/dependency-extraction-webpack-plugin)
+provides a webpack plugin to help extract WordPress dependencies from bundles. `@wordpress/scripts`
+[`build`](https://github.com/WordPress/gutenberg/tree/master/packages/scripts#build) script includes
+the plugin by default.
diff --git a/docs/manifest.json b/docs/manifest.json
index 4a7815af08489f..56e1f6134609b4 100644
--- a/docs/manifest.json
+++ b/docs/manifest.json
@@ -629,6 +629,12 @@
 		"markdown_source": "https://raw.githubusercontent.com/WordPress/gutenberg/master/packages/date/README.md",
 		"parent": "packages"
 	},
+	{
+		"title": "@wordpress/dependency-extraction-webpack-plugin",
+		"slug": "packages-dependency-extraction-webpack-plugin",
+		"markdown_source": "https://raw.githubusercontent.com/WordPress/gutenberg/master/packages/dependency-extraction-webpack-plugin/README.md",
+		"parent": "packages"
+	},
 	{
 		"title": "@wordpress/deprecated",
 		"slug": "packages-deprecated",
diff --git a/package-lock.json b/package-lock.json
index ae38ead8423e73..98d911fb16f024 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -3140,6 +3140,32 @@
 				"moment-timezone": "^0.5.16"
 			}
 		},
+		"@wordpress/dependency-extraction-webpack-plugin": {
+			"version": "file:packages/dependency-extraction-webpack-plugin",
+			"dev": true,
+			"requires": {
+				"webpack": "^4.8.3",
+				"webpack-sources": "^1.3.0"
+			},
+			"dependencies": {
+				"source-map": {
+					"version": "0.6.1",
+					"resolved": "https://registry.npmjs.org/source-map/-/source-map-0.6.1.tgz",
+					"integrity": "sha512-UjgapumWlbMhkBgzT7Ykc5YXUT46F0iKu8SGXq0bcwP5dz/h0Plj6enJqjz1Zbq2l5WaqYnrVbwWOWMyF3F47g==",
+					"dev": true
+				},
+				"webpack-sources": {
+					"version": "1.3.0",
+					"resolved": "https://registry.npmjs.org/webpack-sources/-/webpack-sources-1.3.0.tgz",
+					"integrity": "sha512-OiVgSrbGu7NEnEvQJJgdSFPl2qWKkWq5lHMhgiToIiN9w34EBnjYzSYs+VbL5KoYiLNtFFa7BZIKxRED3I32pA==",
+					"dev": true,
+					"requires": {
+						"source-list-map": "^2.0.0",
+						"source-map": "~0.6.1"
+					}
+				}
+			}
+		},
 		"@wordpress/deprecated": {
 			"version": "file:packages/deprecated",
 			"requires": {
@@ -3467,6 +3493,7 @@
 			"dev": true,
 			"requires": {
 				"@wordpress/babel-preset-default": "file:packages/babel-preset-default",
+				"@wordpress/dependency-extraction-webpack-plugin": "file:packages/dependency-extraction-webpack-plugin",
 				"@wordpress/eslint-plugin": "file:packages/eslint-plugin",
 				"@wordpress/jest-preset-default": "file:packages/jest-preset-default",
 				"@wordpress/npm-package-json-lint-config": "file:packages/npm-package-json-lint-config",
diff --git a/package.json b/package.json
index 3809fad588fb81..57628c9262c083 100644
--- a/package.json
+++ b/package.json
@@ -66,6 +66,7 @@
 		"@wordpress/babel-preset-default": "file:packages/babel-preset-default",
 		"@wordpress/browserslist-config": "file:packages/browserslist-config",
 		"@wordpress/custom-templated-path-webpack-plugin": "file:packages/custom-templated-path-webpack-plugin",
+		"@wordpress/dependency-extraction-webpack-plugin": "file:packages/dependency-extraction-webpack-plugin",
 		"@wordpress/docgen": "file:packages/docgen",
 		"@wordpress/e2e-test-utils": "file:packages/e2e-test-utils",
 		"@wordpress/e2e-tests": "file:packages/e2e-tests",
diff --git a/packages/dependency-extraction-webpack-plugin/CHANGELOG.md b/packages/dependency-extraction-webpack-plugin/CHANGELOG.md
new file mode 100644
index 00000000000000..46c5eb68883748
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/CHANGELOG.md
@@ -0,0 +1,5 @@
+## Unreleased
+
+### New Feature
+
+- Introduce the `@wordpress/dependency-extraction-webpack-plugin` package.
diff --git a/packages/dependency-extraction-webpack-plugin/README.md b/packages/dependency-extraction-webpack-plugin/README.md
new file mode 100644
index 00000000000000..78cf2abcb7486e
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/README.md
@@ -0,0 +1,196 @@
+# Dependency Extraction Webpack Plugin
+
+This webpack plugin serves two purposes:
+
+- Externalize dependencies that are available as script dependencies on modern WordPress sites.
+- Add a JSON file for each entrypoint that declares the WordPress script dependencies for the
+  entrypoint.
+
+This allows JavaScript bundles produced by webpack to leverage WordPress style dependency sharing
+without an error-prone process of manually maintaining a dependency list.
+
+Consult the [webpack website](https://webpack.js.org) for additional information on webpack concepts.
+
+## Installation
+
+Install the module
+
+```bash
+npm install @wordpress/dependency-extraction-webpack-plugin --save-dev
+```
+
+## Usage
+
+### Webpack
+
+Use this plugin as you would other webpack plugins:
+
+```js
+// webpack.config.js
+const WordPressExternalDependenciesPlugin = require( '@wordpress/dependency-extraction-webpack-plugin' );
+
+module.exports = {
+  // …snip
+  plugins: [
+    new WordPressExternalDependenciesPlugin(),
+  ]
+}
+```
+
+Each entrypoint in the webpack bundle will include JSON file that declares the WordPress script dependencies that should be enqueued.
+
+For example:
+
+```
+// Source file entrypoint.js
+import { Component } from '@wordpress/element';
+
+// Webpack will produce the output output/entrypoint.js
+/* bundled JavaScript output */
+
+// Webpack will also produce output/entrypoint.deps.json declaring script dependencies
+['wp-element']
+```
+
+By default, the following module requests are handled:
+
+| Request | Global | Script handle |
+| --- | --- | --- |
+| `@babel/runtime/regenerator` | `regeneratorRuntime` | `wp-polyfill` |
+| `@wordpress/*` | `wp['*']` | `wp-*` |
+| `jquery` | `jQuery` | `jquery` |
+| `jquery` | `jQuery` | `jquery` |
+| `lodash-es` | `lodash` | `lodash` |
+| `lodash` | `lodash` | `lodash` |
+| `moment` | `moment` | `moment` |
+| `react-dom` | `ReactDOM` | `react-dom` |
+| `react` | `React` | `react` |
+
+**Note:** This plugin overlaps with the functionality provided by [webpack
+`externals`](https://webpack.js.org/configuration/externals). This plugin is intended to extract
+script handles from bundle compilation so that a list of script dependencies does not need to be
+manually maintained. If you don't need to extract a list of script dependencies, use the `externals`
+option directly.
+
+This plugin is compatible with `externals`, but they may conflict. For example, adding
+`{ externals: { '@wordpress/blob': 'wp.blob' } }` to webpack configuration will effectively hide the
+`@wordpress/blob` module from the plugin and it will not be included in dependency lists.
+
+#### Options
+
+An object can be passed to the constructor to customize the behavior, for example:
+
+```js
+module.exports = {
+  plugins: [
+    new WordPressExternalDependenciesPlugin( { injectPolyfill: true } ),
+  ]
+}
+```
+
+##### `useDefaults`
+
+- Type: boolean
+- Default: `true`
+
+Pass `useDefaults: false` to disable the default request handling.
+
+##### `injectPolyfill`
+
+- Type: boolean
+- Default: `false`
+
+Force `wp-polyfill` to be included in each entrypoint's dependency list. This would be the same as
+adding `import '@wordpress/polyfill';` to each entrypoint.
+
+##### `requestToExternal`
+
+- Type: function
+
+`requestToExternal` allows the module handling to be customized. The function should accept a
+module request string and may return a string representing the global variable to use. An array of
+strings may be used to access globals via an object path, e.g. `wp.i18n` may be represented as `[
+'wp', 'i18n' ]`.
+
+`requestToExternal` provided via configuration has precedence over default external handling.
+Unhandled requests will be handled by the default unless `useDefaults` is set to `false`.
+
+```js
+/**
+ * Externalize 'my-module'
+ *
+ * @param {string} request Requested module
+ *
+ * @return {(string|undefined)} Script global
+ */
+function requestToExternal( request ) {
+
+  // Handle imports like `import myModule from 'my-module'`
+  if ( request === 'my-module' ) {
+    // Expect to find `my-module` as myModule in the global scope:
+    return 'myModule';
+  }
+}
+
+module.exports = {
+  plugins: [
+    new WordPressExternalDependenciesPlugin( { requestToExternal } ),
+  ]
+}
+```
+
+##### `requestToHandle`
+
+- Type: function
+
+All of the external modules handled by the plugin are expected to be WordPress script dependencies
+and will be added to the dependency list. `requestToHandle` allows the script handle included in the dependency list to be customized.
+
+If no string is returned, the script handle is assumed to be the same as the request.
+
+`requestToHandle` provided via configuration has precedence over the defaults. Unhandled requests will be handled by the default unless `useDefaults` is set to `false`.
+
+```js
+/**
+ * Map 'my-module' request to 'my-module-script-handle'
+ *
+ * @param {string} request Requested module
+ *
+ * @return {(string|undefined)} Script global
+ */
+function requestToHandle( request ) {
+
+  // Handle imports like `import myModule from 'my-module'`
+  if ( request === 'my-module' ) {
+    // Expect to find `my-module` as myModule in the global scope:
+    return 'my-module-script-handle';
+  }
+}
+
+module.exports = {
+  plugins: [
+    new WordPressExternalDependenciesPlugin( { requestToExternal } ),
+  ]
+}
+```
+
+##### `requestToExternal` and `requestToHandle`
+
+The functions `requestToExternal` and `requestToHandle` allow this module to handle arbitrary
+modules. `requestToExternal` is necessary to handle any module and maps a module request to a global
+name. `requestToHandle` maps the same module request to a script handle, the strings that will be
+included in the `entrypoint.deps.json` files.
+
+### WordPress
+
+Enqueue your script as usual and read the script dependencies dynamically:
+
+```php
+$script_path         = 'path/to/script.js';
+$script_deps_path    = 'path/to/script.deps.json';
+$script_dependencies = file_exists( $script_deps_path )
+	? json_decode( file_get_contents( $script_deps_path ) )
+	: array();
+$script_url = plugins_url( $script_path, __FILE__ );
+wp_enqueue_script( 'script', $script_url, $script_dependencies );
+```
diff --git a/packages/dependency-extraction-webpack-plugin/index.js b/packages/dependency-extraction-webpack-plugin/index.js
new file mode 100644
index 00000000000000..5e067856671cd4
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/index.js
@@ -0,0 +1,135 @@
+/**
+ * External dependencies
+ */
+const { createHash } = require( 'crypto' );
+const { ExternalsPlugin } = require( 'webpack' );
+const { RawSource } = require( 'webpack-sources' );
+
+/**
+ * Internal dependencies
+ */
+const { defaultRequestToExternal, defaultRequestToHandle } = require( './util' );
+
+class DependencyExtractionWebpackPlugin {
+	constructor( options ) {
+		this.options = Object.assign(
+			{
+				injectPolyfill: false,
+				useDefaults: true,
+			},
+			options
+		);
+
+		// Track requests that are externalized.
+		//
+		// Because we don't have a closed set of dependencies, we need to track what has
+		// been externalized so we can recognize them in a later phase when the dependency
+		// lists are generated.
+		this.externalizedDeps = new Set();
+
+		// Offload externalization work to the ExternalsPlugin.
+		this.externalsPlugin = new ExternalsPlugin( 'this', this.externalizeWpDeps.bind( this ) );
+	}
+
+	externalizeWpDeps( context, request, callback ) {
+		let externalRequest;
+
+		// Handle via options.requestToExternal first
+		if ( typeof this.options.requestToExternal === 'function' ) {
+			externalRequest = this.options.requestToExternal( request );
+		}
+
+		// Cascade to default if unhandled and enabled
+		if ( typeof externalRequest === 'undefined' && this.options.useDefaults ) {
+			externalRequest = defaultRequestToExternal( request );
+		}
+
+		if ( externalRequest ) {
+			this.externalizedDeps.add( request );
+
+			return callback( null, { this: externalRequest } );
+		}
+
+		return callback();
+	}
+
+	mapRequestToDependency( request ) {
+		// Handle via options.requestToDependency first
+		if ( typeof this.options.requestToDependency === 'function' ) {
+			const scriptDependency = this.options.requestToDependency( request );
+			if ( scriptDependency ) {
+				return scriptDependency;
+			}
+		}
+
+		// Cascade to default if enabled
+		if ( this.options.useDefaults ) {
+			const scriptDependency = defaultRequestToHandle( request );
+			if ( scriptDependency ) {
+				return scriptDependency;
+			}
+		}
+
+		// Fall back to the request name
+		return request;
+	}
+
+	apply( compiler ) {
+		this.externalsPlugin.apply( compiler );
+
+		const { output } = compiler.options;
+		const { filename: outputFilename } = output;
+
+		compiler.hooks.emit.tap( this.constructor.name, ( compilation ) => {
+			// Process each entrypoint independently.
+			for ( const [ entrypointName, entrypoint ] of compilation.entrypoints.entries() ) {
+				const entrypointExternalizedWpDeps = new Set();
+				if ( this.options.injectPolyfill ) {
+					entrypointExternalizedWpDeps.add( 'wp-polyfill' );
+				}
+
+				// Search for externalized modules in all chunks.
+				for ( const chunk of entrypoint.chunks ) {
+					for ( const { userRequest } of chunk.modulesIterable ) {
+						if ( this.externalizedDeps.has( userRequest ) ) {
+							const scriptDependency = this.mapRequestToDependency( userRequest );
+							entrypointExternalizedWpDeps.add( scriptDependency );
+						}
+					}
+				}
+
+				// Build a stable JSON string that declares the WordPress script dependencies.
+				const sortedDepsArray = Array.from( entrypointExternalizedWpDeps ).sort();
+				const depsString = JSON.stringify( sortedDepsArray );
+
+				// Determine a filename for the `[entrypoint].deps.json` file.
+				const [ filename, query ] = entrypointName.split( '?', 2 );
+				const depsFilename = compilation.getPath(
+					outputFilename.replace( /\.js$/i, '.deps.json' ),
+					{
+						chunk: entrypoint.getRuntimeChunk(),
+						filename,
+						query,
+						basename: basename( filename ),
+						contentHash: createHash( 'md4' )
+							.update( depsString )
+							.digest( 'hex' ),
+					}
+				);
+
+				// Add source and file into compilation for webpack to output.
+				compilation.assets[ depsFilename ] = new RawSource( depsString );
+				entrypoint.getRuntimeChunk().files.push( depsFilename );
+			}
+		} );
+	}
+}
+
+function basename( name ) {
+	if ( ! name.includes( '/' ) ) {
+		return name;
+	}
+	return name.substr( name.lastIndexOf( '/' ) + 1 );
+}
+
+module.exports = DependencyExtractionWebpackPlugin;
diff --git a/packages/dependency-extraction-webpack-plugin/package.json b/packages/dependency-extraction-webpack-plugin/package.json
new file mode 100644
index 00000000000000..9d3e816fcbb1a2
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/package.json
@@ -0,0 +1,32 @@
+{
+	"name": "@wordpress/dependency-extraction-webpack-plugin",
+	"version": "1.0.0-alpha.0",
+	"description": "Extract WordPress script dependencies from webpack bundles.",
+	"author": "The WordPress Contributors",
+	"license": "GPL-2.0-or-later",
+	"keywords": [
+		"wordpress",
+		"webpack",
+		"dependency"
+	],
+	"homepage": "https://github.com/WordPress/gutenberg/tree/master/packages/dependency-extraction-webpack-plugin/README.md",
+	"repository": {
+		"type": "git",
+		"url": "https://github.com/WordPress/gutenberg.git",
+		"directory": "packages/dependency-extraction-webpack-plugin"
+	},
+	"bugs": {
+		"url": "https://github.com/WordPress/gutenberg/issues"
+	},
+	"files": [
+		"index.js"
+	],
+	"main": "index.js",
+	"dependencies": {
+		"webpack": "^4.8.3",
+		"webpack-sources": "^1.3.0"
+	},
+	"publishConfig": {
+		"access": "public"
+	}
+}
diff --git a/packages/dependency-extraction-webpack-plugin/test/__snapshots__/build.js.snap b/packages/dependency-extraction-webpack-plugin/test/__snapshots__/build.js.snap
new file mode 100644
index 00000000000000..37d144bb4a6397
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/test/__snapshots__/build.js.snap
@@ -0,0 +1,182 @@
+// Jest Snapshot v1, https://goo.gl/fbAQLP
+
+exports[`Webpack \`dynamic-import\` should produce expected output: Dependencies JSON should match snapshot 1`] = `
+Array [
+  "lodash",
+  "wp-blob",
+]
+`;
+
+exports[`Webpack \`dynamic-import\` should produce expected output: External modules should match snapshot 1`] = `
+Array [
+  Object {
+    "externalType": "this",
+    "request": Object {
+      "this": Array [
+        "wp",
+        "blob",
+      ],
+    },
+    "userRequest": "@wordpress/blob",
+  },
+  Object {
+    "externalType": "this",
+    "request": Object {
+      "this": "lodash",
+    },
+    "userRequest": "lodash",
+  },
+]
+`;
+
+exports[`Webpack \`no-default\` should produce expected output: Dependencies JSON should match snapshot 1`] = `Array []`;
+
+exports[`Webpack \`no-default\` should produce expected output: External modules should match snapshot 1`] = `Array []`;
+
+exports[`Webpack \`no-deps\` should produce expected output: Dependencies JSON should match snapshot 1`] = `Array []`;
+
+exports[`Webpack \`no-deps\` should produce expected output: External modules should match snapshot 1`] = `Array []`;
+
+exports[`Webpack \`overrides\` should produce expected output: Dependencies JSON should match snapshot 1`] = `
+Array [
+  "wp-blob",
+  "wp-script-handle-for-rxjs",
+  "wp-url",
+]
+`;
+
+exports[`Webpack \`overrides\` should produce expected output: External modules should match snapshot 1`] = `
+Array [
+  Object {
+    "externalType": "this",
+    "request": Object {
+      "this": Array [
+        "wp",
+        "blob",
+      ],
+    },
+    "userRequest": "@wordpress/blob",
+  },
+  Object {
+    "externalType": "this",
+    "request": Object {
+      "this": Array [
+        "wp",
+        "url",
+      ],
+    },
+    "userRequest": "@wordpress/url",
+  },
+  Object {
+    "externalType": "this",
+    "request": Object {
+      "this": Array [
+        "rxjs",
+        "operators",
+      ],
+    },
+    "userRequest": "rxjs/operators",
+  },
+  Object {
+    "externalType": "this",
+    "request": Object {
+      "this": "rxjs",
+    },
+    "userRequest": "rxjs",
+  },
+]
+`;
+
+exports[`Webpack \`with-externs\` should produce expected output: Dependencies JSON should match snapshot 1`] = `
+Array [
+  "wp-url",
+]
+`;
+
+exports[`Webpack \`with-externs\` should produce expected output: External modules should match snapshot 1`] = `
+Array [
+  Object {
+    "externalType": "var",
+    "request": "wp.blob",
+    "userRequest": "@wordpress/blob",
+  },
+  Object {
+    "externalType": "this",
+    "request": Object {
+      "this": Array [
+        "wp",
+        "url",
+      ],
+    },
+    "userRequest": "@wordpress/url",
+  },
+  Object {
+    "externalType": "var",
+    "request": "rxjs.operators",
+    "userRequest": "rxjs/operators",
+  },
+  Object {
+    "externalType": "var",
+    "request": "rxjs",
+    "userRequest": "rxjs",
+  },
+]
+`;
+
+exports[`Webpack \`wordpress\` should produce expected output: Dependencies JSON should match snapshot 1`] = `
+Array [
+  "lodash",
+  "wp-blob",
+]
+`;
+
+exports[`Webpack \`wordpress\` should produce expected output: External modules should match snapshot 1`] = `
+Array [
+  Object {
+    "externalType": "this",
+    "request": Object {
+      "this": Array [
+        "wp",
+        "blob",
+      ],
+    },
+    "userRequest": "@wordpress/blob",
+  },
+  Object {
+    "externalType": "this",
+    "request": Object {
+      "this": "lodash",
+    },
+    "userRequest": "lodash",
+  },
+]
+`;
+
+exports[`Webpack \`wordpress-require\` should produce expected output: Dependencies JSON should match snapshot 1`] = `
+Array [
+  "lodash",
+  "wp-blob",
+]
+`;
+
+exports[`Webpack \`wordpress-require\` should produce expected output: External modules should match snapshot 1`] = `
+Array [
+  Object {
+    "externalType": "this",
+    "request": Object {
+      "this": Array [
+        "wp",
+        "blob",
+      ],
+    },
+    "userRequest": "@wordpress/blob",
+  },
+  Object {
+    "externalType": "this",
+    "request": Object {
+      "this": "lodash",
+    },
+    "userRequest": "lodash",
+  },
+]
+`;
diff --git a/packages/dependency-extraction-webpack-plugin/test/build.js b/packages/dependency-extraction-webpack-plugin/test/build.js
new file mode 100644
index 00000000000000..af24b3f6dbf364
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/test/build.js
@@ -0,0 +1,75 @@
+/**
+ * External dependencies
+ */
+const fs = require( 'fs' );
+const glob = require( 'glob' ).sync;
+const mkdirp = require( 'mkdirp' ).sync;
+const path = require( 'path' );
+const rimraf = require( 'rimraf' ).sync;
+const webpack = require( 'webpack' );
+
+const fixturesPath = path.join( __dirname, 'fixtures' );
+const configFixtures = fs.readdirSync( fixturesPath ).sort();
+
+afterAll( () => rimraf( path.join( __dirname, 'build' ) ) );
+
+describe.each( configFixtures )( 'Webpack `%s`', ( configCase ) => {
+	const testDirectory = path.join( fixturesPath, configCase );
+	const outputDirectory = path.join( __dirname, 'build', configCase );
+
+	beforeEach( () => {
+		rimraf( outputDirectory );
+		mkdirp( outputDirectory );
+	} );
+
+	// This afterEach is necessary to prevent watched tests from retriggering on every run.
+	afterEach( () => rimraf( outputDirectory ) );
+
+	test( 'should produce expected output', () =>
+		new Promise( ( resolve ) => {
+			const options = Object.assign(
+				{
+					context: testDirectory,
+					entry: './index.js',
+					mode: 'production',
+					optimization: {
+						minimize: false,
+						namedChunks: true,
+						namedModules: true,
+					},
+					output: {},
+				},
+				require( path.join( testDirectory, 'webpack.config.js' ) )
+			);
+			options.output.path = outputDirectory;
+
+			webpack( options, ( err, stats ) => {
+				expect( err ).toBeNull();
+
+				const depsFiles = glob( `${ outputDirectory }/*.deps.json` );
+				const expectedLength =
+					typeof options.entry === 'object' ? Object.keys( options.entry ).length : 1;
+				expect( depsFiles ).toHaveLength( expectedLength );
+
+				// Deps files should match
+				depsFiles.forEach( ( depsFile ) => {
+					expect( require( depsFile ) ).toMatchSnapshot(
+						'Dependencies JSON should match snapshot'
+					);
+				} );
+
+				// Webpack stats external modules should match
+				const externalModules = stats.compilation.modules
+					.filter( ( { external } ) => external )
+					.sort()
+					.map( ( module ) => ( {
+						externalType: module.externalType,
+						request: module.request,
+						userRequest: module.userRequest,
+					} ) );
+				expect( externalModules ).toMatchSnapshot( 'External modules should match snapshot' );
+
+				resolve();
+			} );
+		} ) );
+} );
diff --git a/packages/dependency-extraction-webpack-plugin/test/fixtures/dynamic-import/index.js b/packages/dependency-extraction-webpack-plugin/test/fixtures/dynamic-import/index.js
new file mode 100644
index 00000000000000..419272a48cffb8
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/test/fixtures/dynamic-import/index.js
@@ -0,0 +1,6 @@
+/**
+ * External dependencies
+ */
+import _ from 'lodash';
+
+import( './util' ).then( _.noop );
diff --git a/packages/dependency-extraction-webpack-plugin/test/fixtures/dynamic-import/util.js b/packages/dependency-extraction-webpack-plugin/test/fixtures/dynamic-import/util.js
new file mode 100644
index 00000000000000..57dd4db43468dd
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/test/fixtures/dynamic-import/util.js
@@ -0,0 +1,6 @@
+/**
+ * WordPress dependencies
+ */
+import { isBlobURL } from '@wordpress/blob';
+
+isBlobURL();
diff --git a/packages/dependency-extraction-webpack-plugin/test/fixtures/dynamic-import/webpack.config.js b/packages/dependency-extraction-webpack-plugin/test/fixtures/dynamic-import/webpack.config.js
new file mode 100644
index 00000000000000..ca6a3e9e85a75d
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/test/fixtures/dynamic-import/webpack.config.js
@@ -0,0 +1,5 @@
+const DependencyExtractionWebpackPlugin = require( '../../..' );
+
+module.exports = {
+	plugins: [ new DependencyExtractionWebpackPlugin() ],
+};
diff --git a/packages/dependency-extraction-webpack-plugin/test/fixtures/no-default/index.js b/packages/dependency-extraction-webpack-plugin/test/fixtures/no-default/index.js
new file mode 100644
index 00000000000000..612e420c2a6c4d
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/test/fixtures/no-default/index.js
@@ -0,0 +1,6 @@
+/**
+ * External dependencies
+ */
+import _ from 'lodash';
+
+_.map( [], _.identity );
diff --git a/packages/dependency-extraction-webpack-plugin/test/fixtures/no-default/webpack.config.js b/packages/dependency-extraction-webpack-plugin/test/fixtures/no-default/webpack.config.js
new file mode 100644
index 00000000000000..2b009fba2cc4fe
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/test/fixtures/no-default/webpack.config.js
@@ -0,0 +1,5 @@
+const DependencyExtractionWebpackPlugin = require( '../../..' );
+
+module.exports = {
+	plugins: [ new DependencyExtractionWebpackPlugin( { useDefaults: false } ) ],
+};
diff --git a/packages/dependency-extraction-webpack-plugin/test/fixtures/no-deps/index.js b/packages/dependency-extraction-webpack-plugin/test/fixtures/no-deps/index.js
new file mode 100644
index 00000000000000..4bfad0baa7885d
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/test/fixtures/no-deps/index.js
@@ -0,0 +1 @@
+/* Silence is golden */
diff --git a/packages/dependency-extraction-webpack-plugin/test/fixtures/no-deps/webpack.config.js b/packages/dependency-extraction-webpack-plugin/test/fixtures/no-deps/webpack.config.js
new file mode 100644
index 00000000000000..ca6a3e9e85a75d
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/test/fixtures/no-deps/webpack.config.js
@@ -0,0 +1,5 @@
+const DependencyExtractionWebpackPlugin = require( '../../..' );
+
+module.exports = {
+	plugins: [ new DependencyExtractionWebpackPlugin() ],
+};
diff --git a/packages/dependency-extraction-webpack-plugin/test/fixtures/overrides/index.js b/packages/dependency-extraction-webpack-plugin/test/fixtures/overrides/index.js
new file mode 100644
index 00000000000000..21fda20b8d8fad
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/test/fixtures/overrides/index.js
@@ -0,0 +1,18 @@
+/**
+ * WordPress dependencies
+ */
+import { isBlobURL } from '@wordpress/blob';
+import { isURL } from '@wordpress/url';
+
+/**
+ * External dependencies
+ */
+import { range } from 'rxjs';
+import { map, filter } from 'rxjs/operators';
+
+range( 1, 200 )
+	.pipe(
+		filter( isBlobURL ),
+		map( ( x ) => x + x )
+	)
+	.subscribe( ( x ) => isURL( x ) );
diff --git a/packages/dependency-extraction-webpack-plugin/test/fixtures/overrides/webpack.config.js b/packages/dependency-extraction-webpack-plugin/test/fixtures/overrides/webpack.config.js
new file mode 100644
index 00000000000000..e72c63ad010a25
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/test/fixtures/overrides/webpack.config.js
@@ -0,0 +1,22 @@
+const DependencyExtractionWebpackPlugin = require( '../../..' );
+
+module.exports = {
+	plugins: [
+		new DependencyExtractionWebpackPlugin( {
+			requestToExternal( request ) {
+				if ( request === 'rxjs' ) {
+					return 'rxjs';
+				}
+
+				if ( request === 'rxjs/operators' ) {
+					return [ 'rxjs', 'operators' ];
+				}
+			},
+			requestToDependency( request ) {
+				if ( request === 'rxjs' || request === 'rxjs/operators' ) {
+					return 'wp-script-handle-for-rxjs';
+				}
+			},
+		} ),
+	],
+};
diff --git a/packages/dependency-extraction-webpack-plugin/test/fixtures/with-externs/index.js b/packages/dependency-extraction-webpack-plugin/test/fixtures/with-externs/index.js
new file mode 100644
index 00000000000000..21fda20b8d8fad
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/test/fixtures/with-externs/index.js
@@ -0,0 +1,18 @@
+/**
+ * WordPress dependencies
+ */
+import { isBlobURL } from '@wordpress/blob';
+import { isURL } from '@wordpress/url';
+
+/**
+ * External dependencies
+ */
+import { range } from 'rxjs';
+import { map, filter } from 'rxjs/operators';
+
+range( 1, 200 )
+	.pipe(
+		filter( isBlobURL ),
+		map( ( x ) => x + x )
+	)
+	.subscribe( ( x ) => isURL( x ) );
diff --git a/packages/dependency-extraction-webpack-plugin/test/fixtures/with-externs/webpack.config.js b/packages/dependency-extraction-webpack-plugin/test/fixtures/with-externs/webpack.config.js
new file mode 100644
index 00000000000000..fe7038fe04a1ec
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/test/fixtures/with-externs/webpack.config.js
@@ -0,0 +1,10 @@
+const DependencyExtractionWebpackPlugin = require( '../../..' );
+
+module.exports = {
+	externals: {
+		'@wordpress/blob': 'wp.blob',
+		'rxjs/operators': 'rxjs.operators',
+		rxjs: true,
+	},
+	plugins: [ new DependencyExtractionWebpackPlugin() ],
+};
diff --git a/packages/dependency-extraction-webpack-plugin/test/fixtures/wordpress-require/index.js b/packages/dependency-extraction-webpack-plugin/test/fixtures/wordpress-require/index.js
new file mode 100644
index 00000000000000..30a2be6ebcada1
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/test/fixtures/wordpress-require/index.js
@@ -0,0 +1,11 @@
+/**
+ * WordPress dependencies
+ */
+const { isBlobURL } = require( '@wordpress/blob' );
+
+/**
+ * External dependencies
+ */
+const _ = require( 'lodash' );
+
+_.isEmpty( isBlobURL( '' ) );
diff --git a/packages/dependency-extraction-webpack-plugin/test/fixtures/wordpress-require/webpack.config.js b/packages/dependency-extraction-webpack-plugin/test/fixtures/wordpress-require/webpack.config.js
new file mode 100644
index 00000000000000..ca6a3e9e85a75d
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/test/fixtures/wordpress-require/webpack.config.js
@@ -0,0 +1,5 @@
+const DependencyExtractionWebpackPlugin = require( '../../..' );
+
+module.exports = {
+	plugins: [ new DependencyExtractionWebpackPlugin() ],
+};
diff --git a/packages/dependency-extraction-webpack-plugin/test/fixtures/wordpress/index.js b/packages/dependency-extraction-webpack-plugin/test/fixtures/wordpress/index.js
new file mode 100644
index 00000000000000..917b4cd7e204bf
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/test/fixtures/wordpress/index.js
@@ -0,0 +1,11 @@
+/**
+ * WordPress dependencies
+ */
+import { isBlobURL } from '@wordpress/blob';
+
+/**
+ * External dependencies
+ */
+import _ from 'lodash';
+
+_.isEmpty( isBlobURL( '' ) );
diff --git a/packages/dependency-extraction-webpack-plugin/test/fixtures/wordpress/webpack.config.js b/packages/dependency-extraction-webpack-plugin/test/fixtures/wordpress/webpack.config.js
new file mode 100644
index 00000000000000..ca6a3e9e85a75d
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/test/fixtures/wordpress/webpack.config.js
@@ -0,0 +1,5 @@
+const DependencyExtractionWebpackPlugin = require( '../../..' );
+
+module.exports = {
+	plugins: [ new DependencyExtractionWebpackPlugin() ],
+};
diff --git a/packages/dependency-extraction-webpack-plugin/test/util.js b/packages/dependency-extraction-webpack-plugin/test/util.js
new file mode 100644
index 00000000000000..f7d5f166b7d56a
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/test/util.js
@@ -0,0 +1,41 @@
+/**
+ * Internal dependencies
+ */
+const { defaultRequestToExternal, defaultRequestToHandle } = require( '../util' );
+
+describe( 'defaultRequestToExternal', () => {
+	test( 'Returns undefined on unrecognized request', () => {
+		expect( defaultRequestToExternal( 'unknown-request' ) ).toBeUndefined();
+	} );
+
+	test( 'Handles known lodash-es request', () => {
+		expect( defaultRequestToExternal( 'lodash-es' ) ).toBe( 'lodash' );
+	} );
+
+	test( 'Handles known @wordpress request', () => {
+		expect( defaultRequestToExternal( '@wordpress/i18n' ) ).toEqual( [ 'wp', 'i18n' ] );
+	} );
+
+	test( 'Handles future @wordpress namespace packages', () => {
+		expect( defaultRequestToExternal( '@wordpress/some-future-package' ) ).toEqual( [
+			'wp',
+			'someFuturePackage',
+		] );
+	} );
+} );
+
+describe( 'defaultRequestToHandle', () => {
+	test( 'Handles known lodash-es request', () => {
+		expect( defaultRequestToHandle( 'lodash-es' ) ).toBe( 'lodash' );
+	} );
+
+	test( 'Handles known @wordpress request', () => {
+		expect( defaultRequestToHandle( '@wordpress/i18n' ) ).toBe( 'wp-i18n' );
+	} );
+
+	test( 'Handles  @wordpress request', () => {
+		expect( defaultRequestToHandle( '@wordpress/some-future-package' ) ).toBe(
+			'wp-some-future-package'
+		);
+	} );
+} );
diff --git a/packages/dependency-extraction-webpack-plugin/util.js b/packages/dependency-extraction-webpack-plugin/util.js
new file mode 100644
index 00000000000000..b8b7238fe2a9a1
--- /dev/null
+++ b/packages/dependency-extraction-webpack-plugin/util.js
@@ -0,0 +1,85 @@
+const WORDPRESS_NAMESPACE = '@wordpress/';
+
+/**
+ * Default request to global transformation
+ *
+ * Transform @wordpress dependencies:
+ *   @wordpress/api-fetch -> wp.apiFetch
+ *   @wordpress/i18n -> wp.i18n
+ *
+ * @param {string} request Requested module
+ *
+ * @return {(string|string[]|undefined)} Script global
+ */
+function defaultRequestToExternal( request ) {
+	switch ( request ) {
+		case 'moment':
+			return request;
+
+		case '@babel/runtime/regenerator':
+			return 'regeneratorRuntime';
+
+		case 'lodash':
+		case 'lodash-es':
+			return 'lodash';
+
+		case 'jquery':
+			return 'jQuery';
+
+		case 'react':
+			return 'React';
+
+		case 'react-dom':
+			return 'ReactDOM';
+	}
+
+	if ( request.startsWith( WORDPRESS_NAMESPACE ) ) {
+		return [ 'wp', camelCaseDash( request.substring( WORDPRESS_NAMESPACE.length ) ) ];
+	}
+}
+
+/**
+ * Default request to WordPress script handle transformation
+ *
+ * Transform @wordpress dependencies:
+ *   @wordpress/i18n -> wp-i18n
+ *   @wordpress/escape-html -> wp-escape-html
+ *
+ * @param {string} request Requested module
+ *
+ * @return {(string|undefined)} Script handle
+ */
+function defaultRequestToHandle( request ) {
+	switch ( request ) {
+		case '@babel/runtime/regenerator':
+			return 'wp-polyfill';
+
+		case 'lodash-es':
+			return 'lodash';
+	}
+
+	if ( request.startsWith( WORDPRESS_NAMESPACE ) ) {
+		return 'wp-' + request.substring( WORDPRESS_NAMESPACE.length );
+	}
+}
+
+/**
+ * Given a string, returns a new string with dash separators converted to
+ * camelCase equivalent. This is not as aggressive as `_.camelCase` in
+ * converting to uppercase, where Lodash will also capitalize letters
+ * following numbers.
+ *
+ * Temporarily duplicated from @wordpress/scripts/utils.
+ *
+ * @param {string} string Input dash-delimited string.
+ *
+ * @return {string} Camel-cased string.
+ */
+function camelCaseDash( string ) {
+	return string.replace( /-([a-z])/g, ( match, letter ) => letter.toUpperCase() );
+}
+
+module.exports = {
+	defaultRequestToExternal,
+	defaultRequestToHandle,
+};
diff --git a/packages/scripts/CHANGELOG.md b/packages/scripts/CHANGELOG.md
index 962e9eb4b471f0..a030be54312745 100644
--- a/packages/scripts/CHANGELOG.md
+++ b/packages/scripts/CHANGELOG.md
@@ -1,3 +1,10 @@
+## Unreleased
+
+### New Feature
+
+- Leverage `@wordpress/dependency-extraction-webpack-plugin` plugin to extract WordPress
+  dependencies.
+
 ## 3.1.0 (2019-03-20)
 
 ## New features
diff --git a/packages/scripts/README.md b/packages/scripts/README.md
index 80b130073a1661..b21c7078a61d56 100644
--- a/packages/scripts/README.md
+++ b/packages/scripts/README.md
@@ -271,17 +271,10 @@ The `build` and `start` commands use [webpack](https://webpack.js.org/) behind t
 
 * [Entry](https://webpack.js.org/configuration/entry-context/#entry): `src/index.js`
 * [Output](https://webpack.js.org/configuration/output): `build/index.js`
-* [Externals](https://webpack.js.org/configuration/externals). These are libraries that are to be found in the global scope:
-
-Package | Input syntax | Output
---- | --- | ---
-React | `import x from 'react';` | `var x = window.React.x;`
-ReactDOM | `import x from 'react-dom';` | `var x = window.ReactDOM.x;`
-moment | `import x from 'moment';` | `var x = window.moment.x;`
-jQuery | `import x from 'jquery';` | `var x = window.jQuery.x;`
-lodash | `import x from 'lodash';` | `var x = window.lodash.x;`
-lodash-es | `import x from 'lodash-es';` | `var x = window.lodash.x;`
-WordPress packages | `import x from '@wordpress/package-name'` | `var x = window.wp.packageName.x`
+* [Plugins](https://webpack.js.org/configuration/plugins): The webpack plugin provided by
+[`@wordpress/dependency-extraction-webpack-plugin`](/packages/dependency-extraction-webpack-plugin/README.md) is used
+with the default configuration to ensure that WordPress provided scripts are not included in the
+built bundle.
 
 #### Provide your own webpack config
 
diff --git a/packages/scripts/config/webpack.config.js b/packages/scripts/config/webpack.config.js
index 65ec3878e7808c..44f173d958e0f9 100644
--- a/packages/scripts/config/webpack.config.js
+++ b/packages/scripts/config/webpack.config.js
@@ -6,62 +6,14 @@ const LiveReloadPlugin = require( 'webpack-livereload-plugin' );
 const path = require( 'path' );
 
 /**
- * Internal dependencies
+ * WordPress dependencies
  */
-const { camelCaseDash, hasBabelConfig } = require( '../utils' );
+const DependencyExtractionWebpackPlugin = require( '@wordpress/dependency-extraction-webpack-plugin' );
 
 /**
- * Converts @wordpress/* string request into request object.
- *
- * Note this isn't the same as camel case because of the
- * way that numbers don't trigger the capitalized next letter.
- *
- * @example
- * formatRequest( '@wordpress/api-fetch' );
- * // { this: [ 'wp', 'apiFetch' ] }
- * formatRequest( '@wordpress/i18n' );
- * // { this: [ 'wp', 'i18n' ] }
- *
- * @param {string} request Request name from import statement.
- * @return {Object} Request object formatted for further processing.
+ * Internal dependencies
  */
-const formatRequest = ( request ) => {
-	// '@wordpress/api-fetch' -> [ '@wordpress', 'api-fetch' ]
-	const [ , name ] = request.split( '/' );
-
-	// { this: [ 'wp', 'apiFetch' ] }
-	return {
-		this: [ 'wp', camelCaseDash( name ) ],
-	};
-};
-
-const wordpressExternals = ( context, request, callback ) => {
-	if ( /^@wordpress\//.test( request ) ) {
-		callback( null, formatRequest( request ), 'this' );
-	} else {
-		callback();
-	}
-};
-
-const externals = [
-	{
-		react: 'React',
-		'react-dom': 'ReactDOM',
-		moment: 'moment',
-		jquery: 'jQuery',
-		lodash: 'lodash',
-		'lodash-es': 'lodash',
-
-		// Distributed NPM packages may depend on Babel's runtime regenerator.
-		// In a WordPress context, the regenerator is assigned to the global
-		// scope via the `wp-polyfill` script. It is reassigned here as an
-		// externals to reduce the size of generated bundles.
-		//
-		// See: https://github.com/WordPress/gutenberg/issues/13890
-		'@babel/runtime/regenerator': 'regeneratorRuntime',
-	},
-	wordpressExternals,
-];
+const { hasBabelConfig } = require( '../utils' );
 
 const isProduction = process.env.NODE_ENV === 'production';
 const mode = isProduction ? 'production' : 'development';
@@ -75,7 +27,6 @@ const config = {
 		filename: '[name].js',
 		path: path.resolve( process.cwd(), 'build' ),
 	},
-	externals,
 	resolve: {
 		alias: {
 			'lodash-es': 'lodash',
@@ -116,6 +67,7 @@ const config = {
 		// WP_LIVE_RELOAD_PORT global variable changes port on which live reload works
 		// when running watch mode.
 		! isProduction && new LiveReloadPlugin( { port: process.env.WP_LIVE_RELOAD_PORT || 35729 } ),
+		new DependencyExtractionWebpackPlugin(),
 	].filter( Boolean ),
 	stats: {
 		children: false,
diff --git a/packages/scripts/package.json b/packages/scripts/package.json
index 0edf052d93add1..e61e6958b8ce40 100644
--- a/packages/scripts/package.json
+++ b/packages/scripts/package.json
@@ -33,6 +33,7 @@
 	},
 	"dependencies": {
 		"@wordpress/babel-preset-default": "file:../babel-preset-default",
+		"@wordpress/dependency-extraction-webpack-plugin": "file:../dependency-extraction-webpack-plugin",
 		"@wordpress/eslint-plugin": "file:../eslint-plugin",
 		"@wordpress/jest-preset-default": "file:../jest-preset-default",
 		"@wordpress/npm-package-json-lint-config": "file:../npm-package-json-lint-config",