-
Notifications
You must be signed in to change notification settings - Fork 1
/
8method.html
250 lines (226 loc) · 15.7 KB
/
8method.html
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
<!DOCTYPE HTML>
<!--
Helios by HTML5 UP
html5up.net | @ajlkn
Free for personal and commercial use under the CCA 3.0 license (html5up.net/license)
-->
<html>
<head>
<title>Wang Lab - research</title>
<meta charset="utf-8" />
<meta name="viewport" content="width=device-width, initial-scale=1" />
<!--[if lte IE 8]><script src="assets/js/ie/html5shiv.js"></script><![endif]-->
<link rel="stylesheet" href="assets/css/main.css" />
<!--[if lte IE 8]><link rel="stylesheet" href="assets/css/ie8.css" /><![endif]-->
<base target="_blank">
</head>
<body class="right-sidebar">
<div id="page-wrapper">
<!-- Header -->
<div id="header">
<!-- Inner -->
<div class="inner">
<header>
<h1><a href="index.html" id="logo"> Research Highlights - Methods </a></h1>
</header>
</div>
<!-- shared navigation starts here -->
<nav id="nav">
<ul>
<li><a href="index.html" target="_self">Home</a></li>
<!--research headlin-->
<li>
<a href="#">Research</a>
<ul>
<li><a href="1review.html" target="_self"> Review Articles </a></li>
<li><a href="2coding.html" target="_self"> Neural Coding </a></li>
<li><a href="3vocalization.html" target="_self"> Vocalization </a></li>
<li><a href="4pitch.html" target="_self"> Pitch and Harmonics </a></li>
<li><a href="5localization.html" target="_self"> Sound Localization </a></li>
<li><a href="6ci.html" target="_self"> Cochlear Implant</a></li>
<li><a href="7behav.html" target="_self"> Behavior and Psychophysics </a></li>
<li><a href="8method.html" target="_self"> Methods </a></li>
</ul>
</li>
<!--people headline (left-sidebar)-->
<li><a href="people.html" target="_self">People</a></li>
<!--publication headline (right-sidebar-->
<li><a href="publication.html" target="_self"> Publications </a></li>
<!--photos headline (no sidebar)-->
<li><a href="adventure.html" target="_self">Adventures</a></li>
<li><a href="positions.html" target="_self">Positions</a></li>
</ul>
</nav>
<!-- shared navigation ends here -->
</div>
<!-- Main -->
<div class="wrapper style1">
<div class="container">
<div class="row 200%">
<div class="8u 12u(mobile)" id="content" >
<article id="main" >
<section>
<h3><i> A number of techniques are in use or being developed in the lab, including <b>single-unit extracellular and intracellular recording</b>, <b>wireless multi-channel electrode recording</b>, <b>optogenetics</b>, <b>two-photon chronic imaging</b>, <b>transgenic lines...</b>
</i></h3>
</section>
<!--2012, wireless recording -->
<section>
<h3><a href="http://www.sciencedirect.com/science/article/pii/S0165027011005267">Wireless multi-channel single unit recording in freely moving and vocalizing primates</a></h3>
</section>
<section>
<a href="http://www.sciencedirect.com/science?_ob=MiamiCaptionURL&_method=retrieve&_eid=1-s2.0-S0165027011005267&_image=1-s2.0-S0165027011005267-gr1.jpg&_cid=271055&_explode=defaultEXP_LIST&_idxType=defaultREF_WORK_INDEX_TYPE&_alpha=defaultALPHA&_ba=&_rdoc=1&_fmt=FULL&_issn=01650270&_pii=S0165027011005267&md5=718dfdcb4c24d96ab1a8dd09fb9c7212" class="image research-left"><img src="images/research/8-1.jpg" alt="" /></a>
<P><b>(Sabyasachi and Wang, 2012) </b>The ability to record well-isolated action potentials from individual neurons in naturally behaving animals is crucial for understanding neural mechanisms underlying natural behaviors. Traditional neurophysiology techniques, however, require the animal to be restrained which often restricts natural behavior. An example is the common marmoset (Callithrix jacchus), a highly vocal New World primate species, used in our laboratory to study the neural correlates of vocal production and sensory feedback. This paper describes an experimental setup capable of recording multiple single units from freely roaming and vocalizing small subjects using a novel neural telemetry system. This system is capable of simultaneously recording single units from different cortical sites within a radio frequency and acoustically controlled environment.</P>
<p style="font-size: 14px">
Figure 1. Wireless neural headstage and multi-electrode array. (A) Warp-16 (Neuralynx) sixteen channel multi-electrode array on the left and W16 (TBSI) sixteen channel wireless neural headstage shown on the right. (B) Approximate location of electrode array in the marmoset left hemisphere. (C) Wireless neural headstage and electrode array assembly is shown along with the protective chamber for use during free-roaming recordings. (D) Individual components of the protective cap for the headstage and multi-electrode array assembly.
</p>
</section>
<!--2012, operant conditioning -->
<section>
<h3><a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047895">An Operant Conditioning Method for Studying Auditory Behaviors in Marmoset Monkeys</a></h3>
</section>
<section>
<a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047895" class="image research-right"><img src="images/research/8-2.jpg" alt="" /></a>
<p><b>(Remington et al., 2012)</b>Here we describe an operant conditioning behavioral training method developed to allow controlled psychoacoustic measurements in marmosets. We demonstrate that marmosets can be trained to consistently perform a Go/No-Go auditory task in which a subject licks at a feeding tube when it detects a sound. Correct responses result in delivery of a food reward. Crucially, this operant conditioning task generates little body movement and is well suited for pairing behavior with single-unit electrophysiology. Successful implementation of an operant conditioning behavior opens the door to a wide range of new studies in the field of auditory neuroscience using the marmoset as a model system.</p>
<p style="font-size: 14px">
Figure 1. Marmoset chair and behavior setup. A. Marmoset chair with feeding tube, infrared lick detector, and optional head restraint mechanism for single-unit recording. The neck plate slides out to allow a marmoset to enter the chair from below. After securing neck plate, the feeding tube can be adjusted to create a comfortable reach for each monkey. B. Schematic of task setup. Sounds are played from free field speakers while marmosets lick to target sounds for a reward which is delivered by a syringe pump via a feeding tube. Lick responses are recorded when the infrared beam is broken by the animal’s face or tongue. Behavior apparatus are controlled by a personal computer and powered by a custom built power supply and electrical isolation module.</p>
</section>
</article>
</div>
<div class="4u 12u(mobile)" id="sidebar">
<hr class="first" />
<section>
<!-- related publication -->
<header>
<h3>Related publications</h3>
</header>
<ul>
<li type="square">Roy, Sabyasachi, and Xiaoqin Wang. "Wireless multi-channel single unit recording in freely moving and vocalizing primates." Journal of neuroscience methods 203, no. 1 (2012): 28-40.
<a href="http://www.sciencedirect.com/science/article/pii/S0165027011005267">[web]</a>
<a href="publications/2012_JNeurosciMethods_Roy.pdf"> [pdf]</a>
</li>
<li type="square">Remington, Evan D., Michael S. Osmanski, and Xiaoqin Wang. "An operant conditioning method for studying auditory behaviors in marmoset monkeys."PLoS One 7, no. 10 (2012): e47895.
<a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047895">[web]</a>
<a href="publications/2012_PloSONE_Remington_operantcondition.pdf"> [pdf]</a>
</li>
<li type="square">Eliades, Steven J., and Xiaoqin Wang. "Chronic multi-electrode neural recording in free-roaming monkeys." Journal of neuroscience methods 172, no. 2 (2008): 201-214.
<a href="http://www.sciencedirect.com/science/article/pii/S0165027008002598">[web]</a>
<a href="publications/2008_JNeurosciMethods_Issa_multielectrode.pdf"> [pdf]</a>
</li>
<li type="square">Zhang, Jiangyang, Alan Evans, Laurent Hermoye, Seung-Koo Lee, Setsu Wakana, Weihong Zhang, Pamela Donohue et al. "Evidence of slow maturation of the superior longitudinal fasciculus in early childhood by diffusion tensor imaging." Neuroimage 38, no. 2 (2007): 239-247.
<a href="http://www.sciencedirect.com/science/article/pii/S1053811907006064">[web]</a>
<a href="publications/2007_NeuroImage_ZhangEtAl.pdf"> [pdf]</a>
</li>
<li type="square">Pistorio, Ashley L., Stewart H. Hendry, and Xiaoqin Wang. "A modified technique for high-resolution staining of myelin." Journal of neuroscience methods 153, no. 1 (2006): 135-146.
<a href="http://www.sciencedirect.com/science/article/pii/S0165027005003997">[web]</a>
<a href="publications/2006_JNeurosciMethods_Pistorio_myelin.pdf"> [pdf]</a>
</li>
<li type="square">Mohseni, Pedram, Khalil Najafi, Steven J. Eliades, and Xiaoqin Wang. "Wireless multichannel biopotential recording using an integrated FM telemetry circuit." Neural Systems and Rehabilitation Engineering, IEEE Transactions on 13, no. 3 (2005): 263-271.
<a href="http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=1506813">[web]</a>
<a href="publications/2005_IEEE_Mohseni.pdf"> [pdf]</a>
</li>
</ul>
<footer>
<a href="publication.html" class="button">Full publication list</a>
</footer>
</section>
<hr />
<!-- shared side bar starts here -->
<section>
<header>
<h3><a href="#">Wang Lab Research Projects</a></h3>
</header>
<div class="row 50%">
<div class="4u">
<a href="2coding.html" class="image fit"><img src="images/logo/research-1coding-1.jpg" alt="" /></a>
</div>
<div class="8u">
<h4><a href="2coding.html">Neural Coding in Auditory Cortex</a></h4>
</div>
</div>
<div class="row 50%">
<div class="4u">
<a href="3vocalization.html" class="image fit"><img src="images/logo/research-2vocal-1.jpg" alt="" /></a>
</div>
<div class="8u">
<h4><a href="3vocalization.html">Vocalization</a></h4>
</div>
</div>
<div class="row 50%">
<div class="4u">
<a href="4pitch.html" class="image fit"><img src="images/logo/research-3pitch-1.jpg" alt="" /></a>
</div>
<div class="8u">
<h4><a href="4pitch.html">Pitch and Harmonics</a></h4>
</div>
</div>
<div class="row 50%">
<div class="4u">
<a href="5localization.html" class="image fit"><img src="images//logo/research-5localization-1.jpg" alt="" /></a>
</div>
<div class="8u">
<h4><a href="5localization.html">Sound Localization</a></h4>
</div>
</div>
<div class="row 50%">
<div class="4u">
<a href="6ci.html" class="image fit"><img src="images/logo/research-6ci-1.jpg" alt="" /></a>
</div>
<div class="8u">
<h4><a href="6ci.html">Cochlear Implant</a></h4>
</div>
</div>
<div class="row 50%">
<div class="4u">
<a href="7behav.html" class="image fit"><img src="images/logo/research-7behav-1.jpg" alt="" /></a>
</div>
<div class="8u">
<h4><a href="7behav.html">Behavior and Psychophysics</a></h4>
</div>
</div>
</section>
<!-- shared side bar ends here -->
</div>
</div>
<hr />
</div>
</div>
<!-- Footer -->
<div id="footer">
<div class="container">
<!-- shared section start here -->
<div class="row">
<div class="12u">
<!-- Contact -->
<section class="contact">
<header>
<h3>Contact Info</h3>
</header>
<p>
Department of Biomedical Engineering at Johns Hopkins University <br>
720 Rutland Ave. Traylor 410. Baltimore, MD 21205, USA<br>
Lab Tel: 410.502.6019 | Dr. Wang Tel: 410.614.4547 | Fax: 410.502.2826 <br>
</p>
</section>
<!-- Copyright -->
<div class="copyright">
<ul class="menu">
<li>© Wang Lab at Johns Hopkins University.</li><li>Webmaster: Yueqi Guo <a href="mailto:yguo29@jhu.edu">(contact me)</a></li>
</ul>
</div>
</div>
</div>
<!-- shared section stop here -->
</div>
</div>
</div>
<!-- Scripts -->
<script src="assets/js/jquery.min.js"></script>
<script src="assets/js/jquery.dropotron.min.js"></script>
<script src="assets/js/jquery.scrolly.min.js"></script>
<script src="assets/js/jquery.onvisible.min.js"></script>
<script src="assets/js/skel.min.js"></script>
<script src="assets/js/util.js"></script>
<!--[if lte IE 8]><script src="assets/js/ie/respond.min.js"></script><![endif]-->
<script src="assets/js/main.js"></script>
</body>
</html>