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<!DOCTYPE HTML>
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<title>Wang Lab - Xindong Song</title>
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<li><a href="2coding.html" target="_self"> Neural Coding </a></li>
<li><a href="3vocalization.html" target="_self"> Vocalization </a></li>
<li><a href="4pitch.html" target="_self"> Pitch and Harmonics </a></li>
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<h2><a href="#">Xindong Song </a></h2>
<p><a href="https://kavlijhu.org/funding/awards">Kavli Distinguished Postdocctoral Fellow (2017) </a></p>
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<a href="#" class="image profile"><img src="images/people/Xindong.jpg" alt="" /></a>
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<h3>Education</h3>
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<ul style="list-style-type:square">
<li>PhD, Biomedical Engineering, Johns Hopkins University, Baltimore USA</li>
<li>MS, Biology, Tsinghua University, Beijing CHINA</li>
<li>BS, Electronic Engineering, Tsinghua University, Beijing CHINA</li>
</ul>
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<h3>Research Interest</h3>
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<ul style="list-style-type:square">
<li>Perception and cortical processing of complex sounds (e.g. pitch perception) </li>
<li>Functional organization of the primate auditory cortex at the meso- and micro- scales </li>
<li>Multisensory integration of social-communication related information in the primate cortex </li>
<li>Advanced optical imaging development for studying cortical functions in awake primates</li>
<li>Bridging optical engineering and genetically encoded labeling in primates</li>
</ul>
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<header>
<h3>Current Projects</h3>
</header>
<ul style="list-style-type:square">
<li><i>Development of a multi-scale optical imaging pipeline for mapping cortical functions in awake marmosets</i><br>
1. Develop a through-skull optical imaging paradigm to map functional landscapes composed of multiple cortical areas across sensory modalities in awake marmoset monkeys.<br>
2. Create through-skull-imaging guided procedures for implanting cranial windows to precisely cover the entire auditory cortex on marmoset brain surface.<br>
3. Advance wide-field imaging approaches to map functional architectures in marmoset auditory cortex through intrinsic optical signal and <b><a style="color:Tomato" href="https://vimeo.com/263531752">calcium signal.</a></b><br>
4. Design and built a silent-scanning two-photon microscope for imaging <b><a style="color:Tomato" href="https://vimeo.com/366169810">neuronal activities </b></a>in marmoset auditory cortex without acoustic artifacts.<br>
<li><i>Meso- & Micro-scale Functional Architecture of the “Pitch Center” in Marmosets:</i><br>
Apply through-skull and windowed functional imaging approaches to map cortical landscapes for processing pitch through spectral and temporal mechanisms.<br>
Utilize silent-scanning two-photon microscopy to study cortical pitch processing at the single-neuron level. </li>
<li><i>Pitch Perception Mechanisms in Marmosets</i><br>
Use operant conditioning tasks to reveal cognitive mechanisms for pitch perception in marmosets. </li>
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<header>
<h3>Publications</h3>
</header>
<ul style="list-style-type:square">
<li type="square">Song X, Guo Y, Chen C, Wang X. A silent two-photon imaging system for studying in vivo auditory neuronal functions. Light: Science and Applications. 2022 Apr 14;11(1):1-3.
<a href="https://www.nature.com/articles/s41377-022-00783-y">[web]</a>
<a href="publications/2022_LSA_Song.pdf"> [pdf]</a>
</li>
<li type="square">Song X, Guo Y, Li H, Chen C, Lee JH, Zhang Y, Schmidt Z, Wang X. Mesoscopic landscape of cortical functions revealed by through-skull wide-field optical imaging in marmoset monkeys. Nature Communications. 2022 Apr 26;13(1):1-9.
<a href="https://www.nature.com/articles/s41467-022-29864-7">[web]</a>
<a href="publications/2022_NatComm_Song.pdf"> [pdf]</a>
</li>
<li type="square">Song, Xindong, Michael S. Osmanski, Yueqi Guo, and Xiaoqin Wang. "Complex pitch perception mechanisms are shared by humans and a New World monkey." Proceedings of the National Academy of Sciences 113, no. 3 (2016): 781-786.
<a href="http://www.pnas.org/content/113/3/781.short">[web]</a>
<a href="publications/2016_PNAS_Song_PitchBehavior.pdf"> [pdf]</a>
</li>
<li type="square">Osmanski, Michael S., Xindong Song, Yueqi Guo, and Xiaoqin Wang. "Frequency discrimination in the common marmoset (Callithrix jacchus)" Hearing Research (2016).
<a href="http://www.sciencedirect.com/science/article/pii/S0378595516301733">[web]</a>
<a href="publications/2016_HearingRes_Osmanski.pdf"> [pdf]</a>
</li>
<li type="square">Osmanski, Michael S., Xindong Song, and Xiaoqin Wang. "The role of harmonic resolvability in pitch perception in a vocal nonhuman primate, the common marmoset (Callithrix jacchus)." The Journal of Neuroscience 33, no. 21 (2013): 9161-9168.
<a href="http://www.jneurosci.org/content/33/21/9161.short">[web]</a>
<a href="publications/2013_JNeurosci_Osmanski_resolvability.pdf"> [pdf]</a>
</li>
<li type="square">Pan, L., Song, X., Xiang, G., Wong, A., Xing, W., Cheng, J., et al. (2009). First-spike rank order as a reliable indicator of burst initiation and its relation with early-to-fire neurons. IEEE transactions on bio-medical engineering, 56(6), 1673-82. doi: 10.1109/TBME.2009.2015652.
</li>
<li type="square">Xiang, G., Pan, L., Huang, L., Yu, Z., Song, X., Cheng, J., et al. (2007). Microelectrode array-based system for neuropharmacological applications with cortical neurons cultured in vitro. Biosensors and bioelectronics, 22(11), 2478-84. doi: 10.1016/j.bios.2006.09.026.</li>
<li type="square">Bian, C., Song, X., Liu, Z., & Zhang, H. (2005). Design proposal of imaging activities of cultured neural network on a silicon substrate with neural-electronic-optical integrated microsystem. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society 7, 7600-3. doi: 10.1109/IEMBS.2005.1616271.</li>
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<h3><a href="#">Contact</a></h3>
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<p>
Xindong Song <br>
720 Rutland Ave. Traylor 412 <br>
Baltimore, MD 21205 <br>
email: <a href="mailto:xsong6@jhmi.edu"> xsong6 AT jhmi.edu </a><br>
Link: <a href="http://song.thuee.net/">personal website</a>
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Department of Biomedical Engineering at Johns Hopkins University <br>
720 Rutland Ave. Traylor 410. Baltimore, MD 21205, USA<br>
Lab Tel: 410.502.6019 | Dr. Wang Tel: 410.614.4547 | Fax: 410.502.2826 <br>
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