diff --git a/src/api/python/setup.py b/src/api/python/setup.py
index 572b0a7a735..56f310fff76 100644
--- a/src/api/python/setup.py
+++ b/src/api/python/setup.py
@@ -129,6 +129,17 @@ def _configure_z3():
     for key, val in cmake_options.items():
         if type(val) is bool:
             cmake_options[key] = str(val).upper()
+
+    # Allow command-line arguments to add and override Z3_ options
+    for i in range(len(sys.argv) - 1):
+        key = sys.argv[i]
+        if key.starts_with("Z3_"):
+            val = sys.argv[i + 1]
+            if val.lower() == "true":
+                cmake_options[key] = "TRUE"
+            elif val.lower() == "false":
+                cmake_options[key] = "FALSE"
+                
     cmake_args = [ '-D' + key + '=' + value for key,value in cmake_options.items() ]
     args = [ 'cmake', *cmake_args, SRC_DIR ]
     if subprocess.call(args, env=build_env, cwd=BUILD_DIR) != 0: