diff --git a/release/src/main/python-release/python_release_automation.sh b/release/src/main/python-release/python_release_automation.sh
index 5fdfee781022e..83a267c71ae4a 100755
--- a/release/src/main/python-release/python_release_automation.sh
+++ b/release/src/main/python-release/python_release_automation.sh
@@ -19,7 +19,7 @@
 source release/src/main/python-release/run_release_candidate_python_quickstart.sh
 source release/src/main/python-release/run_release_candidate_python_mobile_gaming.sh
 
-for version in 3.6 3.7 3.8
+for version in 3.7 3.8 3.9 3.10
 do
   run_release_candidate_python_quickstart    "tar"   "python${version}"
   run_release_candidate_python_mobile_gaming "tar"   "python${version}"
diff --git a/release/src/main/python-release/python_release_automation_utils.sh b/release/src/main/python-release/python_release_automation_utils.sh
index b328c428a7973..b8fccae0eced8 100644
--- a/release/src/main/python-release/python_release_automation_utils.sh
+++ b/release/src/main/python-release/python_release_automation_utils.sh
@@ -82,14 +82,14 @@ function get_version() {
 #######################################
 function download_files() {
   if [[ $1 = *"wheel"* ]]; then
-    if [[ $2 == "python3.6" ]]; then
-      BEAM_PYTHON_SDK_WHL="apache_beam-$VERSION*-cp36-cp36m-manylinux1_x86_64.whl"
-    elif [[ $2 == "python3.7" ]]; then
+    if [[ $2 == "python3.7" ]]; then
       BEAM_PYTHON_SDK_WHL="apache_beam-$VERSION*-cp37-cp37m-manylinux1_x86_64.whl"
     elif [[ $2 == "python3.8" ]]; then
       BEAM_PYTHON_SDK_WHL="apache_beam-$VERSION*-cp38-cp38-manylinux1_x86_64.whl"
     elif [[ $2 == "python3.9" ]]; then
       BEAM_PYTHON_SDK_WHL="apache_beam-$VERSION*-cp39-cp39-manylinux1_x86_64.whl"
+    elif [[ $2 == "python3.10" ]]; then
+      BEAM_PYTHON_SDK_WHL="apache_beam-$VERSION*-cp310-cp310-manylinux1_x86_64.whl"
     else
       echo "Unable to determine a Beam wheel for interpreter version $2."
       exit 1
diff --git a/release/src/main/scripts/mass_comment.py b/release/src/main/scripts/mass_comment.py
index 64d272aa01b36..dde2fc7e8e04a 100644
--- a/release/src/main/scripts/mass_comment.py
+++ b/release/src/main/scripts/mass_comment.py
@@ -92,6 +92,7 @@
     "Run Python 3.7 PostCommit",
     "Run Python 3.8 PostCommit",
     "Run Python 3.9 PostCommit",
+    "Run Python 3.10 PostCommit",
     "Run Python Dataflow V2 ValidatesRunner",
     "Run Python Dataflow ValidatesContainer",
     "Run Python Dataflow ValidatesRunner",