diff --git a/setup.cfg b/setup.cfg
index a4f48d820e982..1e16680ee0b4e 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -30,7 +30,7 @@ combine_as_imports = true
 include_trailing_comma = true
 line_length = 88
 known_first_party = superset
-known_third_party =alembic,apispec,backoff,bleach,cachelib,celery,click,colorama,cron_descriptor,croniter,cryptography,dateutil,deprecation,flask,flask_appbuilder,flask_babel,flask_caching,flask_compress,flask_jwt_extended,flask_login,flask_migrate,flask_sqlalchemy,flask_talisman,flask_testing,flask_wtf,freezegun,geohash,geopy,graphlib,holidays,humanize,isodate,jinja2,jwt,markdown,markupsafe,marshmallow,marshmallow_enum,msgpack,numpy,pandas,parameterized,parsedatetime,pgsanity,pkg_resources,polyline,prison,progress,pyarrow,pyhive,pyinstrument,pyparsing,pytest,pytest_mock,pytz,redis,requests,selenium,setuptools,simplejson,slack,sqlalchemy,sqlalchemy_utils,sqlparse,tabulate,typing_extensions,werkzeug,wtforms,wtforms_json,yaml
+known_third_party =alembic,apispec,backoff,bleach,cachelib,celery,click,colorama,cron_descriptor,croniter,cryptography,dateutil,deprecation,flask,flask_appbuilder,flask_babel,flask_caching,flask_compress,flask_jwt_extended,flask_login,flask_migrate,flask_sqlalchemy,flask_talisman,flask_testing,flask_wtf,freezegun,geohash,geopy,graphlib,holidays,humanize,isodate,jinja2,jwt,markdown,markupsafe,marshmallow,marshmallow_enum,msgpack,numpy,pandas,parameterized,parsedatetime,pgsanity,pkg_resources,polyline,prison,progress,pyarrow,pyhive,pyparsing,pytest,pytest_mock,pytz,redis,requests,selenium,setuptools,simplejson,slack,sqlalchemy,sqlalchemy_utils,sqlparse,tabulate,typing_extensions,werkzeug,wtforms,wtforms_json,yaml
 multi_line_output = 3
 order_by_type = false
 
diff --git a/superset/utils/profiler.py b/superset/utils/profiler.py
index 38de88e775f06..f63a1950780ea 100644
--- a/superset/utils/profiler.py
+++ b/superset/utils/profiler.py
@@ -18,9 +18,13 @@
 from typing import Any, Callable
 from unittest import mock
 
-from pyinstrument import Profiler
 from werkzeug.wrappers import Request, Response
 
+try:
+    from pyinstrument import Profiler
+except ModuleNotFoundError:
+    Profiler = None
+
 
 class SupersetProfiler:
     """
@@ -41,6 +45,9 @@ def __call__(self, request: Request) -> Response:
         if request.args.get("_instrument") != "1":
             return Response.from_app(self.app, request.environ)
 
+        if Profiler is None:
+            raise Exception("The module pyinstrument is not installed.")
+
         profiler = Profiler(interval=self.interval)
 
         # call original request