diff --git a/tests/scripts/setup-pytest-env.sh b/tests/scripts/setup-pytest-env.sh
index b77d3f37cd3e..34b8c61e40b2 100755
--- a/tests/scripts/setup-pytest-env.sh
+++ b/tests/scripts/setup-pytest-env.sh
@@ -33,12 +33,17 @@ export TVM_PYTEST_RESULT_DIR="${TVM_PATH}/build/pytest-results"
 mkdir -p "${TVM_PYTEST_RESULT_DIR}"
 
 function run_pytest() {
-    test_suite_name="$1"
+    local ffi_type="$1"
     shift
-    for ffi_type in ${TVM_PYTEST_FFI_TYPES:-ctypes cython}; do
-        TVM_FFI=${ffi_type} python3 -m pytest \
+    local test_suite_name="$1"
+    shift
+    if [ -z "${ffi_type}" -o -z "${test_suite_name}" ]; then
+        echo "error: run_pytest called incorrectly: run_pytest ${ffi_type} ${test_suite_name} $@"
+        echo "usage: run_pytest <FFI_TYPE> <TEST_SUITE_NAME> [pytest args...]"
+        exit 2
+    fi
+    TVM_FFI=${ffi_type} python3 -m pytest \
            -o "junit_suite_name=${test_suite_name}-${ffi_type}" \
            "--junit-xml=${TVM_PYTEST_RESULT_DIR}/${test_suite_name}-${ffi_type}.xml" \
            "$@"
-    done
 }
diff --git a/tests/scripts/task_python_arm_compute_library.sh b/tests/scripts/task_python_arm_compute_library.sh
index 4c1992b58692..7df894d93399 100755
--- a/tests/scripts/task_python_arm_compute_library.sh
+++ b/tests/scripts/task_python_arm_compute_library.sh
@@ -27,5 +27,4 @@ source tests/scripts/setup-pytest-env.sh
 find . -type f -path "*.pyc" | xargs rm -f
 make cython3
 
-TVM_PYTEST_FFI_TYPES=ctypes run_pytest python-arm_compute_lib \
-                    tests/python/contrib/test_arm_compute_lib
+run_pytest ctypes python-arm_compute_lib tests/python/contrib/test_arm_compute_lib
diff --git a/tests/scripts/task_python_ethosn_tests.sh b/tests/scripts/task_python_ethosn_tests.sh
index 472ca38149a1..981d5715fac6 100755
--- a/tests/scripts/task_python_ethosn_tests.sh
+++ b/tests/scripts/task_python_ethosn_tests.sh
@@ -27,4 +27,4 @@ source tests/scripts/setup-pytest-env.sh
 find . -type f -path "*.pyc" | xargs rm -f
 make cython3
 
-TVM_PYTEST_FFI_TYPES=ctypes run_pytest python-ethosn tests/python/contrib/test_ethosn
+run_pytest ctypes python-ethosn tests/python/contrib/test_ethosn
diff --git a/tests/scripts/task_python_frontend.sh b/tests/scripts/task_python_frontend.sh
index 6b1d8e5038fb..62a0fa1e7fc8 100755
--- a/tests/scripts/task_python_frontend.sh
+++ b/tests/scripts/task_python_frontend.sh
@@ -32,22 +32,22 @@ find . -type f -path "*.pyc" | xargs rm -f
 make cython3
 
 echo "Running relay MXNet frontend test..."
-TVM_PYTHON_FFI_TYPES=cython run_pytest python-frontend-mxnet tests/python/frontend/mxnet
+run_pytest cython python-frontend-mxnet tests/python/frontend/mxnet
 
 echo "Running relay ONNX frontend test..."
-TVM_PYTHON_FFI_TYPES=cython run_pytest python-frontend-onnx tests/python/frontend/onnx
+run_pytest cython python-frontend-onnx tests/python/frontend/onnx
 
 echo "Running relay CoreML frontend test..."
-TVM_PYTHON_FFI_TYPES=cython run_pytest python-frontend-coreml tests/python/frontend/coreml
+run_pytest cython python-frontend-coreml tests/python/frontend/coreml
 
 echo "Running relay Tensorflow frontend test..."
-TVM_PYTHON_FFI_TYPES=cython run_pytest python-frontend-tensorflow tests/python/frontend/tensorflow
+run_pytest cython python-frontend-tensorflow tests/python/frontend/tensorflow
 
 echo "Running relay caffe2 frontend test..."
-TVM_PYTHON_FFI_TYPES=cython run_pytest python-frontend-caffe2 tests/python/frontend/caffe2
+run_pytest cython python-frontend-caffe2 tests/python/frontend/caffe2
 
 echo "Running relay DarkNet frontend test..."
-TVM_PYTHON_FFI_TYPES=cython run_pytest python-frontend-darknet tests/python/frontend/darknet
+run_pytest cython python-frontend-darknet tests/python/frontend/darknet
 
 echo "Running relay PyTorch frontend test..."
-TVM_PYTHON_FFI_TYPES=cython run_pytest python-frontend-pytorch tests/python/frontend/pytorch
+run_pytest cython python-frontend-pytorch tests/python/frontend/pytorch
diff --git a/tests/scripts/task_python_frontend_cpu.sh b/tests/scripts/task_python_frontend_cpu.sh
index a5cd3ba8ef09..208714c64988 100755
--- a/tests/scripts/task_python_frontend_cpu.sh
+++ b/tests/scripts/task_python_frontend_cpu.sh
@@ -33,10 +33,10 @@ find . -type f -path "*.pyc" | xargs rm -f
 make cython3
 
 echo "Running relay TFLite frontend test..."
-TVM_PYTHON_FFI_TYPES=cython run_pytest python-frontend-tflite tests/python/frontend/tflite
+run_pytest cython python-frontend-tflite tests/python/frontend/tflite
 
 echo "Running relay Keras frontend test..."
-TVM_PYTHON_FFI_TYPES=cython run_pytest python-frontend-keras tests/python/frontend/keras
+run_pytest cython python-frontend-keras tests/python/frontend/keras
 
 echo "Running relay Caffe frontend test..."
-TVM_PYTHON_FFI_TYPES=cython run_pytest python-frontend-caffe tests/python/frontend/caffe
+run_pytest cython python-frontend-caffe tests/python/frontend/caffe
diff --git a/tests/scripts/task_python_integration.sh b/tests/scripts/task_python_integration.sh
index dc96097fb115..e21aa065a024 100755
--- a/tests/scripts/task_python_integration.sh
+++ b/tests/scripts/task_python_integration.sh
@@ -27,6 +27,7 @@ export LD_LIBRARY_PATH="build:${LD_LIBRARY_PATH:-}"
 export TVM_BIND_THREADS=0
 export TVM_NUM_THREADS=2
 
+# NOTE: also set by task_python_integration_gpuonly.sh.
 if [ -z "${TVM_INTEGRATION_TESTSUITE_NAME:-}" ]; then
     TVM_INTEGRATION_TESTSUITE_NAME=python-integration
 fi
@@ -43,28 +44,29 @@ rm -rf lib
 make
 cd ../..
 
-run_pytest ${TVM_INTEGRATION_TESTSUITE_NAME}-extensions apps/extension/tests
+run_pytest ctypes ${TVM_INTEGRATION_TESTSUITE_NAME}-extensions apps/extension/tests
+run_pytest cython ${TVM_INTEGRATION_TESTSUITE_NAME}-extensions apps/extension/tests
 
 # Test dso plugin
 cd apps/dso_plugin_module
 rm -rf lib
 make
 cd ../..
-run_pytest ${TVM_INTEGRATION_TESTSUITE_NAME}-dso_plugin_module apps/dso_plugin_module
+run_pytest ctypes ${TVM_INTEGRATION_TESTSUITE_NAME}-dso_plugin_module apps/dso_plugin_module
+run_pytest cython ${TVM_INTEGRATION_TESTSUITE_NAME}-dso_plugin_module apps/dso_plugin_module
 
 # Do not enable TensorFlow op
 # TVM_FFI=cython sh prepare_and_test_tfop_module.sh
 # TVM_FFI=ctypes sh prepare_and_test_tfop_module.sh
 
-TVM_PYTEST_FFI_TYPES=ctypes run_pytest ${TVM_INTEGRATION_TESTSUITE_NAME} tests/python/integration
-TVM_PYTEST_FFI_TYPES=ctypes run_pytest ${TVM_INTEGRATION_TESTSUITE_NAME}-contrib tests/python/contrib
+run_pytest ctypes ${TVM_INTEGRATION_TESTSUITE_NAME} tests/python/integration
+run_pytest ctypes ${TVM_INTEGRATION_TESTSUITE_NAME}-contrib tests/python/contrib
 
 TVM_TEST_TARGETS="${TVM_RELAY_TEST_TARGETS:-llvm;cuda}" \
-                TVM_PYTEST_FFI_TYPES=ctypes \
-                run_pytest ${TVM_INTEGRATION_TESTSUITE_NAME}-relay tests/python/relay
+    run_pytest ctypes ${TVM_INTEGRATION_TESTSUITE_NAME}-relay tests/python/relay
 
 # Command line driver test
-TVM_PYTEST_FFI_TYPES=ctypes run_pytest ${TVM_INTEGRATION_TESTSUITE_NAME}-driver tests/python/driver
+run_pytest ctypes ${TVM_INTEGRATION_TESTSUITE_NAME}-driver tests/python/driver
 
 # Do not enable OpenGL
-# run_pytest ${TVM_INTEGRATION_TESTSUITE_NAME}-webgl tests/webgl
+# run_pytest ctypes ${TVM_INTEGRATION_TESTSUITE_NAME}-webgl tests/webgl
diff --git a/tests/scripts/task_python_microtvm.sh b/tests/scripts/task_python_microtvm.sh
index ddedff37c6c2..ba8018667895 100755
--- a/tests/scripts/task_python_microtvm.sh
+++ b/tests/scripts/task_python_microtvm.sh
@@ -25,4 +25,4 @@ source tests/scripts/setup-pytest-env.sh
 find . -type f -path "*.pyc" | xargs rm -f
 
 make cython3
-run_pytest python-microtvm-qemu tests/micro/qemu
+run_pytest ctypes python-microtvm-qemu tests/micro/qemu
diff --git a/tests/scripts/task_python_nightly.sh b/tests/scripts/task_python_nightly.sh
index bff0650b0bed..16c94dfdad31 100755
--- a/tests/scripts/task_python_nightly.sh
+++ b/tests/scripts/task_python_nightly.sh
@@ -27,4 +27,4 @@ make cython3
 # cleanup pycache
 find . -type f -path "*.pyc" | xargs rm -f
 
-TVM_PYTEST_FFI_TYPES=cython run_pytest python-topi-nightly tests/python/topi/nightly
+run_pytest cython python-topi-nightly tests/python/topi/nightly
diff --git a/tests/scripts/task_python_topi.sh b/tests/scripts/task_python_topi.sh
index e5eb6f28276a..9a5991e6a766 100755
--- a/tests/scripts/task_python_topi.sh
+++ b/tests/scripts/task_python_topi.sh
@@ -31,4 +31,4 @@ make cython3
 # cleanup pycache
 find . -type f -path "*.pyc" | xargs rm -f
 
-TVM_PYTHON_FFI_TYPES=cython run_pytest python-topi tests/python/topi/
+run_pytest cython python-topi tests/python/topi/
diff --git a/tests/scripts/task_python_unittest.sh b/tests/scripts/task_python_unittest.sh
index b63d79a99562..54a36f6dcfd4 100755
--- a/tests/scripts/task_python_unittest.sh
+++ b/tests/scripts/task_python_unittest.sh
@@ -25,9 +25,15 @@ source tests/scripts/setup-pytest-env.sh
 find . -type f -path "*.pyc" | xargs rm -f
 make cython3
 
+# NOTE: also set by task_python_unittest_gpuonly.sh.
 if [ -z "${TVM_UNITTEST_TESTSUITE_NAME:-}" ]; then
     TVM_UNITTEST_TESTSUITE_NAME=python-unittest
 fi
 
-run_pytest ${TVM_UNITTEST_TESTSUITE_NAME}-platform-minimal-test tests/python/all-platform-minimal-test
-run_pytest ${TVM_UNITTEST_TESTSUITE_NAME} tests/python/unittest
+# First run minimal test on both ctypes and cython.
+run_pytest ctypes ${TVM_UNITTEST_TESTSUITE_NAME}-platform-minimal-test tests/python/all-platform-minimal-test
+run_pytest cython ${TVM_UNITTEST_TESTSUITE_NAME}-platform-minimal-test tests/python/all-platform-minimal-test
+
+# Then run all unittests on both ctypes and cython.
+run_pytest ctypes ${TVM_UNITTEST_TESTSUITE_NAME} tests/python/unittest
+run_pytest cython ${TVM_UNITTEST_TESTSUITE_NAME} tests/python/unittest
diff --git a/tests/scripts/task_python_vta_fsim.sh b/tests/scripts/task_python_vta_fsim.sh
index 74d14db95d30..4074fb888351 100755
--- a/tests/scripts/task_python_vta_fsim.sh
+++ b/tests/scripts/task_python_vta_fsim.sh
@@ -40,10 +40,8 @@ cp ${VTA_HW_PATH}/config/fsim_sample.json ${VTA_HW_PATH}/config/vta_config.json
 
 # Run unit tests in functional/fast simulator
 echo "Running unittest in fsim..."
-TVM_PYTEST_FFI_TYPES=cython run_pytest python-vta-fsim-unittest \
-                    ${TVM_PATH}/vta/tests/python/unittest
+run_pytest cython python-vta-fsim-unittest ${TVM_PATH}/vta/tests/python/unittest
 
 # Run unit tests in functional/fast simulator
 echo "Running integration test in fsim..."
-TVM_PYTEST_FFI_TYPES=cython run_pytest python-vta-fsim-integration \
-                    ${TVM_PATH}/vta/tests/python/integration
+run_pytest cython python-vta-fsim-integration ${TVM_PATH}/vta/tests/python/integration
diff --git a/tests/scripts/task_python_vta_tsim.sh b/tests/scripts/task_python_vta_tsim.sh
index 4a5c9d7da877..3a6a35e5a06f 100755
--- a/tests/scripts/task_python_vta_tsim.sh
+++ b/tests/scripts/task_python_vta_tsim.sh
@@ -55,13 +55,11 @@ make -C ${VTA_HW_PATH}/hardware/chisel USE_THREADS=0 lib
 
 # Run unit tests in cycle accurate simulator
 echo "Running unittest in tsim..."
-TVM_PYTEST_FFI_TYPES=cython run_pytest python-vta-tsim-unittest \
-                    ${TVM_PATH}/vta/tests/python/unittest
+run_pytest cython python-vta-tsim-unittest ${TVM_PATH}/vta/tests/python/unittest
 
 # Run unit tests in cycle accurate simulator
 echo "Running integration test in tsim..."
-TVM_PYTEST_FFI_TYPES=cython run_pytest python-vta-tsim-integration \
-                    ${TVM_PATH}/vta/tests/python/integration
+run_pytest cython python-vta-tsim-integration ${TVM_PATH}/vta/tests/python/integration
 
 # Reset default fsim simulation
 cp ${VTA_HW_PATH}/config/fsim_sample.json ${VTA_HW_PATH}/config/vta_config.json