diff --git a/Cargo.lock b/Cargo.lock
index 75262925bdbe..9f048263b96f 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -2980,6 +2980,7 @@ dependencies = [
  "uv-client",
  "uv-fs",
  "uv-normalize",
+ "uv-types",
  "uv-warnings",
 ]
 
diff --git a/crates/requirements-txt/Cargo.toml b/crates/requirements-txt/Cargo.toml
index 02851c40a4cf..47eb4ae37e8e 100644
--- a/crates/requirements-txt/Cargo.toml
+++ b/crates/requirements-txt/Cargo.toml
@@ -17,6 +17,7 @@ pep508_rs = { workspace = true, features = ["rkyv", "serde", "non-pep508-extensi
 uv-client = { workspace = true }
 uv-fs = { workspace = true }
 uv-normalize = { workspace = true }
+uv-types = { workspace = true }
 uv-warnings = { workspace = true }
 
 async-recursion = { workspace = true }
diff --git a/crates/requirements-txt/src/lib.rs b/crates/requirements-txt/src/lib.rs
index 0e44ef0727ad..df509a1114f0 100644
--- a/crates/requirements-txt/src/lib.rs
+++ b/crates/requirements-txt/src/lib.rs
@@ -38,6 +38,7 @@ use std::borrow::Cow;
 use std::fmt::{Display, Formatter};
 use std::io;
 use std::path::{Path, PathBuf};
+use std::str::FromStr;
 
 use async_recursion::async_recursion;
 use serde::{Deserialize, Serialize};
@@ -54,6 +55,7 @@ use uv_client::BaseClient;
 use uv_client::BaseClientBuilder;
 use uv_fs::{normalize_url_path, Simplified};
 use uv_normalize::ExtraName;
+use uv_types::{NoBinary, NoBuild, PackageNameSpecifier};
 use uv_warnings::warn_user;
 
 /// We emit one of those for each requirements.txt entry
@@ -82,6 +84,10 @@ enum RequirementsTxtStatement {
     FindLinks(FindLink),
     /// `--no-index`
     NoIndex,
+    /// `--no-binary`
+    NoBinary(NoBinary),
+    /// `only-binary`
+    OnlyBinary(NoBuild),
 }
 
 #[derive(Debug, Clone, PartialEq, Eq)]
@@ -328,6 +334,10 @@ pub struct RequirementsTxt {
     pub find_links: Vec<FindLink>,
     /// Whether to ignore the index, specified with `--no-index`.
     pub no_index: bool,
+    /// Whether to disallow wheels, specified with `--no-binary`.
+    pub no_binary: NoBinary,
+    /// Whether to allow only wheels, specified with `--only-binary`.
+    pub only_binary: NoBuild,
 }
 
 impl RequirementsTxt {
@@ -516,6 +526,12 @@ impl RequirementsTxt {
                 RequirementsTxtStatement::NoIndex => {
                     data.no_index = true;
                 }
+                RequirementsTxtStatement::NoBinary(no_binary) => {
+                    data.no_binary.extend(no_binary);
+                }
+                RequirementsTxtStatement::OnlyBinary(only_binary) => {
+                    data.only_binary.extend(only_binary);
+                }
             }
         }
         Ok(data)
@@ -531,6 +547,8 @@ impl RequirementsTxt {
             extra_index_urls,
             find_links,
             no_index,
+            no_binary,
+            only_binary,
         } = other;
         self.requirements.extend(requirements);
         self.constraints.extend(constraints);
@@ -541,6 +559,8 @@ impl RequirementsTxt {
         self.extra_index_urls.extend(extra_index_urls);
         self.find_links.extend(find_links);
         self.no_index = self.no_index || no_index;
+        self.no_binary.extend(no_binary);
+        self.only_binary.extend(only_binary);
     }
 }
 
@@ -622,6 +642,28 @@ fn parse_entry(
             }
         })?;
         RequirementsTxtStatement::FindLinks(path_or_url)
+    } else if s.eat_if("--no-binary") {
+        let given = parse_value(content, s, |c: char| !['\n', '\r'].contains(&c))?;
+        let specifier = PackageNameSpecifier::from_str(given).map_err(|err| {
+            RequirementsTxtParserError::NoBinary {
+                source: err,
+                specifier: given.to_string(),
+                start,
+                end: s.cursor(),
+            }
+        })?;
+        RequirementsTxtStatement::NoBinary(NoBinary::from_arg(specifier))
+    } else if s.eat_if("--only-binary") {
+        let given = parse_value(content, s, |c: char| !['\n', '\r'].contains(&c))?;
+        let specifier = PackageNameSpecifier::from_str(given).map_err(|err| {
+            RequirementsTxtParserError::NoBinary {
+                source: err,
+                specifier: given.to_string(),
+                start,
+                end: s.cursor(),
+            }
+        })?;
+        RequirementsTxtStatement::OnlyBinary(NoBuild::from_arg(specifier))
     } else if s.at(char::is_ascii_alphanumeric) || s.at(|char| matches!(char, '.' | '/' | '$')) {
         let (requirement, hashes) = parse_requirement_and_hashes(s, content, working_dir)?;
         RequirementsTxtStatement::RequirementEntry(RequirementEntry {
@@ -867,6 +909,18 @@ pub enum RequirementsTxtParserError {
     InvalidEditablePath(String),
     UnsupportedUrl(String),
     MissingRequirementPrefix(String),
+    NoBinary {
+        source: uv_normalize::InvalidNameError,
+        specifier: String,
+        start: usize,
+        end: usize,
+    },
+    OnlyBinary {
+        source: uv_normalize::InvalidNameError,
+        specifier: String,
+        start: usize,
+        end: usize,
+    },
     UnnamedConstraint {
         start: usize,
         end: usize,
@@ -918,6 +972,28 @@ impl RequirementsTxtParserError {
             },
             Self::UnsupportedUrl(url) => Self::UnsupportedUrl(url),
             Self::MissingRequirementPrefix(given) => Self::MissingRequirementPrefix(given),
+            Self::NoBinary {
+                source,
+                specifier,
+                start,
+                end,
+            } => Self::NoBinary {
+                source,
+                specifier,
+                start: start + offset,
+                end: end + offset,
+            },
+            Self::OnlyBinary {
+                source,
+                specifier,
+                start,
+                end,
+            } => Self::OnlyBinary {
+                source,
+                specifier,
+                start: start + offset,
+                end: end + offset,
+            },
             Self::UnnamedConstraint { start, end } => Self::UnnamedConstraint {
                 start: start + offset,
                 end: end + offset,
@@ -969,6 +1045,12 @@ impl Display for RequirementsTxtParserError {
             Self::MissingRequirementPrefix(given) => {
                 write!(f, "Requirement `{given}` looks like a requirements file but was passed as a package name. Did you mean `-r {given}`?")
             }
+            Self::NoBinary { specifier, .. } => {
+                write!(f, "Invalid specifier for `--no-binary`: {specifier}")
+            }
+            Self::OnlyBinary { specifier, .. } => {
+                write!(f, "Invalid specifier for `--only-binary`: {specifier}")
+            }
             Self::UnnamedConstraint { .. } => {
                 write!(f, "Unnamed requirements are not allowed as constraints")
             }
@@ -1011,6 +1093,8 @@ impl std::error::Error for RequirementsTxtParserError {
             Self::InvalidEditablePath(_) => None,
             Self::UnsupportedUrl(_) => None,
             Self::MissingRequirementPrefix(_) => None,
+            Self::NoBinary { source, .. } => Some(source),
+            Self::OnlyBinary { source, .. } => Some(source),
             Self::UnnamedConstraint { .. } => None,
             Self::UnsupportedRequirement { source, .. } => Some(source),
             Self::Pep508 { source, .. } => Some(source),
@@ -1055,6 +1139,20 @@ impl Display for RequirementsTxtFileError {
                     self.file.user_display(),
                 )
             }
+            RequirementsTxtParserError::NoBinary { specifier, .. } => {
+                write!(
+                    f,
+                    "Invalid specifier for `--no-binary` in `{}`: {specifier}",
+                    self.file.user_display(),
+                )
+            }
+            RequirementsTxtParserError::OnlyBinary { specifier, .. } => {
+                write!(
+                    f,
+                    "Invalid specifier for `--only-binary` in `{}`: {specifier}",
+                    self.file.user_display(),
+                )
+            }
             RequirementsTxtParserError::UnnamedConstraint { .. } => {
                 write!(
                     f,
@@ -1653,6 +1751,69 @@ mod test {
             extra_index_urls: [],
             find_links: [],
             no_index: false,
+            no_binary: None,
+            only_binary: None,
+        }
+        "###);
+
+        Ok(())
+    }
+
+    #[tokio::test]
+    async fn nested_no_binary() -> Result<()> {
+        let temp_dir = assert_fs::TempDir::new()?;
+
+        let requirements_txt = temp_dir.child("requirements.txt");
+        requirements_txt.write_str(indoc! {"
+            flask
+            --no-binary :none:
+            -r child.txt
+        "})?;
+
+        let child = temp_dir.child("child.txt");
+        child.write_str(indoc! {"
+            --no-binary flask
+        "})?;
+
+        let requirements = RequirementsTxt::parse(
+            requirements_txt.path(),
+            temp_dir.path(),
+            &BaseClientBuilder::new(),
+        )
+        .await
+        .unwrap();
+        insta::assert_debug_snapshot!(requirements, @r###"
+        RequirementsTxt {
+            requirements: [
+                RequirementEntry {
+                    requirement: Pep508(
+                        Requirement {
+                            name: PackageName(
+                                "flask",
+                            ),
+                            extras: [],
+                            version_or_url: None,
+                            marker: None,
+                        },
+                    ),
+                    hashes: [],
+                    editable: false,
+                },
+            ],
+            constraints: [],
+            editables: [],
+            index_url: None,
+            extra_index_urls: [],
+            find_links: [],
+            no_index: false,
+            no_binary: Packages(
+                [
+                    PackageName(
+                        "flask",
+                    ),
+                ],
+            ),
+            only_binary: None,
         }
         "###);
 
@@ -1689,37 +1850,39 @@ mod test {
         .unwrap();
 
         insta::assert_debug_snapshot!(requirements, @r###"
-            RequirementsTxt {
-                requirements: [],
-                constraints: [],
-                editables: [
-                    EditableRequirement {
-                        url: VerbatimUrl {
-                            url: Url {
-                                scheme: "file",
-                                cannot_be_a_base: false,
-                                username: "",
-                                password: None,
-                                host: None,
-                                port: None,
-                                path: "/foo/bar",
-                                query: None,
-                                fragment: None,
-                            },
-                            given: Some(
-                                "/foo/bar",
-                            ),
+        RequirementsTxt {
+            requirements: [],
+            constraints: [],
+            editables: [
+                EditableRequirement {
+                    url: VerbatimUrl {
+                        url: Url {
+                            scheme: "file",
+                            cannot_be_a_base: false,
+                            username: "",
+                            password: None,
+                            host: None,
+                            port: None,
+                            path: "/foo/bar",
+                            query: None,
+                            fragment: None,
                         },
-                        extras: [],
-                        path: "/foo/bar",
+                        given: Some(
+                            "/foo/bar",
+                        ),
                     },
-                ],
-                index_url: None,
-                extra_index_urls: [],
-                find_links: [],
-                no_index: true,
-            }
-            "###);
+                    extras: [],
+                    path: "/foo/bar",
+                },
+            ],
+            index_url: None,
+            extra_index_urls: [],
+            find_links: [],
+            no_index: true,
+            no_binary: None,
+            only_binary: None,
+        }
+        "###);
 
         Ok(())
     }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-basic.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-basic.txt.snap
index cba9974a9848..aeefa208a7e9 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-basic.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-basic.txt.snap
@@ -161,4 +161,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-constraints-a.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-constraints-a.txt.snap
index e6ab4fe5a38f..3bae2fc6fa87 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-constraints-a.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-constraints-a.txt.snap
@@ -75,4 +75,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-constraints-b.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-constraints-b.txt.snap
index 99d4e0cfb11a..8c311f4b9edc 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-constraints-b.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-constraints-b.txt.snap
@@ -61,4 +61,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-editable.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-editable.txt.snap
index 80ebe3f5841a..e8a8a5090a99 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-editable.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-editable.txt.snap
@@ -66,4 +66,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-empty.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-empty.txt.snap
index 077583693d2f..0a143a451c7e 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-empty.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-empty.txt.snap
@@ -10,4 +10,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-for-poetry.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-for-poetry.txt.snap
index b8d33f818416..513d0925987d 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-for-poetry.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-for-poetry.txt.snap
@@ -108,4 +108,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-include-a.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-include-a.txt.snap
index 54a870e38300..f14751af9039 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-include-a.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-include-a.txt.snap
@@ -50,4 +50,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-include-b.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-include-b.txt.snap
index bf1b07b155e7..07f69a01f553 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-include-b.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-include-b.txt.snap
@@ -25,4 +25,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-poetry-with-hashes.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-poetry-with-hashes.txt.snap
index 0aacf9a39848..318f3047d5ff 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-poetry-with-hashes.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-poetry-with-hashes.txt.snap
@@ -296,4 +296,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-small.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-small.txt.snap
index 00d71b0de0f6..717c063d4fd6 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-small.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-small.txt.snap
@@ -61,4 +61,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-whitespace.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-whitespace.txt.snap
index 80ebe3f5841a..e8a8a5090a99 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-whitespace.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__line-endings-whitespace.txt.snap
@@ -66,4 +66,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-basic.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-basic.txt.snap
index cba9974a9848..aeefa208a7e9 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-basic.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-basic.txt.snap
@@ -161,4 +161,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-constraints-a.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-constraints-a.txt.snap
index e6ab4fe5a38f..3bae2fc6fa87 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-constraints-a.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-constraints-a.txt.snap
@@ -75,4 +75,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-constraints-b.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-constraints-b.txt.snap
index 99d4e0cfb11a..8c311f4b9edc 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-constraints-b.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-constraints-b.txt.snap
@@ -61,4 +61,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-empty.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-empty.txt.snap
index 077583693d2f..0a143a451c7e 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-empty.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-empty.txt.snap
@@ -10,4 +10,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-for-poetry.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-for-poetry.txt.snap
index b8d33f818416..513d0925987d 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-for-poetry.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-for-poetry.txt.snap
@@ -108,4 +108,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-include-a.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-include-a.txt.snap
index 54a870e38300..f14751af9039 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-include-a.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-include-a.txt.snap
@@ -50,4 +50,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-include-b.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-include-b.txt.snap
index bf1b07b155e7..07f69a01f553 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-include-b.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-include-b.txt.snap
@@ -25,4 +25,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-poetry-with-hashes.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-poetry-with-hashes.txt.snap
index 0aacf9a39848..318f3047d5ff 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-poetry-with-hashes.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-poetry-with-hashes.txt.snap
@@ -296,4 +296,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-small.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-small.txt.snap
index 00d71b0de0f6..717c063d4fd6 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-small.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-small.txt.snap
@@ -61,4 +61,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-unix-bare-url.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-unix-bare-url.txt.snap
index ee62fe8aa5ec..1e71a4be417b 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-unix-bare-url.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-unix-bare-url.txt.snap
@@ -93,4 +93,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-whitespace.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-whitespace.txt.snap
index 80ebe3f5841a..e8a8a5090a99 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-whitespace.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-whitespace.txt.snap
@@ -66,4 +66,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-windows-bare-url.txt.snap b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-windows-bare-url.txt.snap
index 2d9c23e15fa5..d78405047fca 100644
--- a/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-windows-bare-url.txt.snap
+++ b/crates/requirements-txt/src/snapshots/requirements_txt__test__parse-windows-bare-url.txt.snap
@@ -93,4 +93,6 @@ RequirementsTxt {
     extra_index_urls: [],
     find_links: [],
     no_index: false,
+    no_binary: None,
+    only_binary: None,
 }
diff --git a/crates/uv-requirements/src/specification.rs b/crates/uv-requirements/src/specification.rs
index 14c779879208..eb73de073e6f 100644
--- a/crates/uv-requirements/src/specification.rs
+++ b/crates/uv-requirements/src/specification.rs
@@ -11,6 +11,7 @@ use requirements_txt::{EditableRequirement, FindLink, RequirementsTxt};
 use uv_client::BaseClientBuilder;
 use uv_fs::Simplified;
 use uv_normalize::{ExtraName, PackageName};
+use uv_types::{NoBinary, NoBuild};
 
 use crate::pyproject::{Pep621Metadata, PyProjectToml};
 use crate::{ExtrasSpecification, RequirementsSource};
@@ -39,6 +40,10 @@ pub struct RequirementsSpecification {
     pub no_index: bool,
     /// The `--find-links` locations to use for fetching packages.
     pub find_links: Vec<FlatIndexLocation>,
+    /// The `--no-binary` flags to enforce when selecting distributions.
+    pub no_binary: NoBinary,
+    /// The `--no-build` flags to enforce when selecting distributions.
+    pub no_build: NoBuild,
 }
 
 impl RequirementsSpecification {
@@ -65,6 +70,8 @@ impl RequirementsSpecification {
                     extra_index_urls: vec![],
                     no_index: false,
                     find_links: vec![],
+                    no_binary: NoBinary::default(),
+                    no_build: NoBuild::default(),
                 }
             }
             RequirementsSource::Editable(name) => {
@@ -82,6 +89,8 @@ impl RequirementsSpecification {
                     extra_index_urls: vec![],
                     no_index: false,
                     find_links: vec![],
+                    no_binary: NoBinary::default(),
+                    no_build: NoBuild::default(),
                 }
             }
             RequirementsSource::RequirementsTxt(path) => {
@@ -114,6 +123,8 @@ impl RequirementsSpecification {
                             FindLink::Path(path) => FlatIndexLocation::Path(path),
                         })
                         .collect(),
+                    no_binary: requirements_txt.no_binary,
+                    no_build: requirements_txt.only_binary,
                 }
             }
             RequirementsSource::PyprojectToml(path) => {
@@ -151,6 +162,8 @@ impl RequirementsSpecification {
                         extra_index_urls: vec![],
                         no_index: false,
                         find_links: vec![],
+                        no_binary: NoBinary::default(),
+                        no_build: NoBuild::default(),
                     }
                 } else {
                     let path = fs_err::canonicalize(path)?;
@@ -172,6 +185,8 @@ impl RequirementsSpecification {
                         extra_index_urls: vec![],
                         no_index: false,
                         find_links: vec![],
+                        no_binary: NoBinary::default(),
+                        no_build: NoBuild::default(),
                     }
                 }
             }
@@ -195,6 +210,8 @@ impl RequirementsSpecification {
                     extra_index_urls: vec![],
                     no_index: false,
                     find_links: vec![],
+                    no_binary: NoBinary::default(),
+                    no_build: NoBuild::default(),
                 }
             }
         })
@@ -240,6 +257,8 @@ impl RequirementsSpecification {
             spec.no_index |= source.no_index;
             spec.extra_index_urls.extend(source.extra_index_urls);
             spec.find_links.extend(source.find_links);
+            spec.no_binary.extend(source.no_binary);
+            spec.no_build.extend(source.no_build);
         }
 
         // Read all constraints, treating _everything_ as a constraint.
@@ -273,6 +292,8 @@ impl RequirementsSpecification {
             spec.no_index |= source.no_index;
             spec.extra_index_urls.extend(source.extra_index_urls);
             spec.find_links.extend(source.find_links);
+            spec.no_binary.extend(source.no_binary);
+            spec.no_build.extend(source.no_build);
         }
 
         // Read all overrides, treating both requirements _and_ constraints as overrides.
@@ -306,6 +327,8 @@ impl RequirementsSpecification {
             spec.no_index |= source.no_index;
             spec.extra_index_urls.extend(source.extra_index_urls);
             spec.find_links.extend(source.find_links);
+            spec.no_binary.extend(source.no_binary);
+            spec.no_build.extend(source.no_build);
         }
 
         Ok(spec)
diff --git a/crates/uv-types/src/build_options.rs b/crates/uv-types/src/build_options.rs
index b9b5b8481a42..81b646576b30 100644
--- a/crates/uv-types/src/build_options.rs
+++ b/crates/uv-types/src/build_options.rs
@@ -47,9 +47,10 @@ impl Display for BuildKind {
     }
 }
 
-#[derive(Debug, Clone)]
+#[derive(Debug, Default, Clone, PartialEq, Eq)]
 pub enum NoBinary {
     /// Allow installation of any wheel.
+    #[default]
     None,
 
     /// Do not allow installation from any wheels.
@@ -60,7 +61,7 @@ pub enum NoBinary {
 }
 
 impl NoBinary {
-    /// Determine the binary installation strategy to use.
+    /// Determine the binary installation strategy to use for the given arguments.
     pub fn from_args(no_binary: Vec<PackageNameSpecifier>) -> Self {
         let combined = PackageNameSpecifiers::from_iter(no_binary.into_iter());
         match combined {
@@ -69,6 +70,54 @@ impl NoBinary {
             PackageNameSpecifiers::Packages(packages) => Self::Packages(packages),
         }
     }
+
+    /// Determine the binary installation strategy to use for the given argument.
+    pub fn from_arg(no_binary: PackageNameSpecifier) -> Self {
+        Self::from_args(vec![no_binary])
+    }
+
+    /// Combine a set of [`NoBinary`] values.
+    #[must_use]
+    pub fn combine(self, other: Self) -> Self {
+        match (self, other) {
+            // If both are `None`, the result is `None`.
+            (Self::None, Self::None) => Self::None,
+            // If either is `All`, the result is `All`.
+            (Self::All, _) | (_, Self::All) => Self::All,
+            // If one is `None`, the result is the other.
+            (Self::Packages(a), Self::None) => Self::Packages(a),
+            (Self::None, Self::Packages(b)) => Self::Packages(b),
+            // If both are `Packages`, the result is the union of the two.
+            (Self::Packages(mut a), Self::Packages(b)) => {
+                a.extend(b);
+                Self::Packages(a)
+            }
+        }
+    }
+
+    /// Extend a [`NoBinary`] value with another.
+    pub fn extend(&mut self, other: Self) {
+        match (&mut *self, other) {
+            // If either is `All`, the result is `All`.
+            (Self::All, _) | (_, Self::All) => *self = Self::All,
+            // If both are `None`, the result is `None`.
+            (Self::None, Self::None) => {
+                // Nothing to do.
+            }
+            // If one is `None`, the result is the other.
+            (Self::Packages(_), Self::None) => {
+                // Nothing to do.
+            }
+            (Self::None, Self::Packages(b)) => {
+                // Take ownership of `b`.
+                *self = Self::Packages(b);
+            }
+            // If both are `Packages`, the result is the union of the two.
+            (Self::Packages(a), Self::Packages(b)) => {
+                a.extend(b);
+            }
+        }
+    }
 }
 
 impl NoBinary {
@@ -78,9 +127,10 @@ impl NoBinary {
     }
 }
 
-#[derive(Debug, Clone, PartialEq)]
+#[derive(Debug, Default, Clone, PartialEq, Eq)]
 pub enum NoBuild {
     /// Allow building wheels from any source distribution.
+    #[default]
     None,
 
     /// Do not allow building wheels from any source distribution.
@@ -91,7 +141,7 @@ pub enum NoBuild {
 }
 
 impl NoBuild {
-    /// Determine the build strategy to use.
+    /// Determine the build strategy to use for the given arguments.
     pub fn from_args(only_binary: Vec<PackageNameSpecifier>, no_build: bool) -> Self {
         if no_build {
             Self::All
@@ -104,6 +154,54 @@ impl NoBuild {
             }
         }
     }
+
+    /// Determine the build strategy to use for the given argument.
+    pub fn from_arg(no_build: PackageNameSpecifier) -> Self {
+        Self::from_args(vec![no_build], false)
+    }
+
+    /// Combine a set of [`NoBuild`] values.
+    #[must_use]
+    pub fn combine(self, other: Self) -> Self {
+        match (self, other) {
+            // If both are `None`, the result is `None`.
+            (Self::None, Self::None) => Self::None,
+            // If either is `All`, the result is `All`.
+            (Self::All, _) | (_, Self::All) => Self::All,
+            // If one is `None`, the result is the other.
+            (Self::Packages(a), Self::None) => Self::Packages(a),
+            (Self::None, Self::Packages(b)) => Self::Packages(b),
+            // If both are `Packages`, the result is the union of the two.
+            (Self::Packages(mut a), Self::Packages(b)) => {
+                a.extend(b);
+                Self::Packages(a)
+            }
+        }
+    }
+
+    /// Extend a [`NoBuild`] value with another.
+    pub fn extend(&mut self, other: Self) {
+        match (&mut *self, other) {
+            // If either is `All`, the result is `All`.
+            (Self::All, _) | (_, Self::All) => *self = Self::All,
+            // If both are `None`, the result is `None`.
+            (Self::None, Self::None) => {
+                // Nothing to do.
+            }
+            // If one is `None`, the result is the other.
+            (Self::Packages(_), Self::None) => {
+                // Nothing to do.
+            }
+            (Self::None, Self::Packages(b)) => {
+                // Take ownership of `b`.
+                *self = Self::Packages(b);
+            }
+            // If both are `Packages`, the result is the union of the two.
+            (Self::Packages(a), Self::Packages(b)) => {
+                a.extend(b);
+            }
+        }
+    }
 }
 
 impl NoBuild {
diff --git a/crates/uv/src/commands/pip_compile.rs b/crates/uv/src/commands/pip_compile.rs
index 5ae5000fe675..5a8e4a188e66 100644
--- a/crates/uv/src/commands/pip_compile.rs
+++ b/crates/uv/src/commands/pip_compile.rs
@@ -68,7 +68,7 @@ pub(crate) async fn pip_compile(
     config_settings: ConfigSettings,
     connectivity: Connectivity,
     no_build_isolation: bool,
-    no_build: &NoBuild,
+    no_build: NoBuild,
     python_version: Option<PythonVersion>,
     exclude_newer: Option<DateTime<Utc>>,
     annotation_style: AnnotationStyle,
@@ -105,6 +105,8 @@ pub(crate) async fn pip_compile(
         extra_index_urls,
         no_index,
         find_links,
+        no_binary: _,
+        no_build: specified_no_build,
     } = RequirementsSpecification::from_sources(
         requirements,
         constraints,
@@ -231,6 +233,9 @@ pub(crate) async fn pip_compile(
         BuildIsolation::Isolated
     };
 
+    // Combine the `--no-build` flags.
+    let no_build = no_build.combine(specified_no_build);
+
     let build_dispatch = BuildDispatch::new(
         &client,
         &cache,
@@ -242,7 +247,7 @@ pub(crate) async fn pip_compile(
         setup_py,
         &config_settings,
         build_isolation,
-        no_build,
+        &no_build,
         &NoBinary::None,
     )
     .with_options(OptionsBuilder::new().exclude_newer(exclude_newer).build());
diff --git a/crates/uv/src/commands/pip_install.rs b/crates/uv/src/commands/pip_install.rs
index 6202ea71eed8..4594dde2d489 100644
--- a/crates/uv/src/commands/pip_install.rs
+++ b/crates/uv/src/commands/pip_install.rs
@@ -70,8 +70,8 @@ pub(crate) async fn pip_install(
     connectivity: Connectivity,
     config_settings: &ConfigSettings,
     no_build_isolation: bool,
-    no_build: &NoBuild,
-    no_binary: &NoBinary,
+    no_build: NoBuild,
+    no_binary: NoBinary,
     strict: bool,
     exclude_newer: Option<DateTime<Utc>>,
     python: Option<String>,
@@ -100,6 +100,8 @@ pub(crate) async fn pip_install(
         extra_index_urls,
         no_index,
         find_links,
+        no_binary: specified_no_binary,
+        no_build: specified_no_build,
         extras: _,
     } = read_requirements(
         requirements,
@@ -213,6 +215,10 @@ pub(crate) async fn pip_install(
         BuildIsolation::Isolated
     };
 
+    // Combine the `--no-binary` and `--no-build` flags.
+    let no_binary = no_binary.combine(specified_no_binary);
+    let no_build = no_build.combine(specified_no_build);
+
     // Create a shared in-memory index.
     let index = InMemoryIndex::default();
 
@@ -231,8 +237,8 @@ pub(crate) async fn pip_install(
         setup_py,
         config_settings,
         build_isolation,
-        no_build,
-        no_binary,
+        &no_build,
+        &no_binary,
     )
     .with_options(OptionsBuilder::new().exclude_newer(exclude_newer).build());
 
@@ -336,8 +342,8 @@ pub(crate) async fn pip_install(
             setup_py,
             config_settings,
             build_isolation,
-            no_build,
-            no_binary,
+            &no_build,
+            &no_binary,
         )
         .with_options(OptionsBuilder::new().exclude_newer(exclude_newer).build())
     };
@@ -348,7 +354,7 @@ pub(crate) async fn pip_install(
         editables,
         site_packages,
         reinstall,
-        no_binary,
+        &no_binary,
         link_mode,
         compile,
         &index_locations,
diff --git a/crates/uv/src/commands/pip_sync.rs b/crates/uv/src/commands/pip_sync.rs
index 83f74e0806b8..32a6dd7f3fdd 100644
--- a/crates/uv/src/commands/pip_sync.rs
+++ b/crates/uv/src/commands/pip_sync.rs
@@ -49,8 +49,8 @@ pub(crate) async fn pip_sync(
     connectivity: Connectivity,
     config_settings: &ConfigSettings,
     no_build_isolation: bool,
-    no_build: &NoBuild,
-    no_binary: &NoBinary,
+    no_build: NoBuild,
+    no_binary: NoBinary,
     strict: bool,
     python: Option<String>,
     system: bool,
@@ -78,6 +78,8 @@ pub(crate) async fn pip_sync(
         extra_index_urls,
         no_index,
         find_links,
+        no_binary: specified_no_binary,
+        no_build: specified_no_build,
     } = RequirementsSpecification::from_simple_sources(sources, &client_builder).await?;
 
     // Validate that the requirements are non-empty.
@@ -165,6 +167,10 @@ pub(crate) async fn pip_sync(
         BuildIsolation::Isolated
     };
 
+    // Combine the `--no-binary` and `--no-build` flags.
+    let no_binary = no_binary.combine(specified_no_binary);
+    let no_build = no_build.combine(specified_no_build);
+
     // Prep the build context.
     let build_dispatch = BuildDispatch::new(
         &client,
@@ -177,8 +183,8 @@ pub(crate) async fn pip_sync(
         setup_py,
         config_settings,
         build_isolation,
-        no_build,
-        no_binary,
+        &no_build,
+        &no_binary,
     );
 
     // Convert from unnamed to named requirements.
@@ -231,7 +237,7 @@ pub(crate) async fn pip_sync(
         .build(
             site_packages,
             reinstall,
-            no_binary,
+            &no_binary,
             &index_locations,
             &cache,
             &venv,
@@ -267,8 +273,8 @@ pub(crate) async fn pip_sync(
             &client,
             venv.interpreter(),
             &flat_index,
-            no_binary,
-            no_build,
+            &no_binary,
+            &no_build,
         )
         .with_reporter(FinderReporter::from(printer).with_length(remote.len() as u64));
         let resolution = wheel_finder.resolve(&remote).await?;
diff --git a/crates/uv/src/main.rs b/crates/uv/src/main.rs
index 977968f97350..c119912a4c46 100644
--- a/crates/uv/src/main.rs
+++ b/crates/uv/src/main.rs
@@ -1538,7 +1538,7 @@ async fn run() -> Result<ExitStatus> {
                     Connectivity::Online
                 },
                 args.no_build_isolation,
-                &no_build,
+                no_build,
                 args.python_version,
                 args.exclude_newer,
                 args.annotation_style,
@@ -1594,8 +1594,8 @@ async fn run() -> Result<ExitStatus> {
                 },
                 &config_settings,
                 args.no_build_isolation,
-                &no_build,
-                &no_binary,
+                no_build,
+                no_binary,
                 args.strict,
                 args.python,
                 args.system,
@@ -1690,8 +1690,8 @@ async fn run() -> Result<ExitStatus> {
                 },
                 &config_settings,
                 args.no_build_isolation,
-                &no_build,
-                &no_binary,
+                no_build,
+                no_binary,
                 args.strict,
                 args.exclude_newer,
                 args.python,
diff --git a/crates/uv/tests/pip_install.rs b/crates/uv/tests/pip_install.rs
index aede6f7d9bdc..7ba2056dc146 100644
--- a/crates/uv/tests/pip_install.rs
+++ b/crates/uv/tests/pip_install.rs
@@ -1408,6 +1408,38 @@ fn reinstall_no_binary() {
     context.assert_command("import anyio").success();
 }
 
+/// Respect `--only-binary` flags in `requirements.txt`
+#[test]
+fn only_binary_requirements_txt() {
+    let context = TestContext::new("3.12");
+
+    let requirements_txt = context.temp_dir.child("requirements.txt");
+    requirements_txt
+        .write_str(indoc! {r"
+        django_allauth==0.51.0
+        --only-binary django_allauth
+        "
+        })
+        .unwrap();
+
+    uv_snapshot!(command(&context)
+        .arg("-r")
+        .arg("requirements.txt")
+        .arg("--strict"), @r###"
+    success: false
+    exit_code: 1
+    ----- stdout -----
+
+    ----- stderr -----
+      × No solution found when resolving dependencies:
+      ╰─▶ Because django-allauth==0.51.0 is unusable because no wheels
+          are usable and building from source is disabled and you require
+          django-allauth==0.51.0, we can conclude that the requirements are
+          unsatisfiable.
+    "###
+    );
+}
+
 /// Install a package into a virtual environment, and ensuring that the executable permissions
 /// are retained.
 ///