diff --git a/crates/uv-resolver/src/lock.rs b/crates/uv-resolver/src/lock.rs
index 078db6050f89..85988255f618 100644
--- a/crates/uv-resolver/src/lock.rs
+++ b/crates/uv-resolver/src/lock.rs
@@ -20,7 +20,7 @@ use distribution_types::{
     GitSourceDist, IndexUrl, PathBuiltDist, PathSourceDist, RegistryBuiltDist, RegistryBuiltWheel,
     RegistrySourceDist, RemoteSource, Resolution, ResolvedDist, ToUrlError,
 };
-use pep440_rs::Version;
+use pep440_rs::{Version, VersionSpecifiers};
 use pep508_rs::{MarkerEnvironment, MarkerTree, VerbatimUrl};
 use platform_tags::{TagCompatibility, TagPriority, Tags};
 use pypi_types::{HashDigest, ParsedArchiveUrl, ParsedGitUrl};
@@ -36,6 +36,8 @@ use crate::{lock, ResolutionGraph};
 pub struct Lock {
     version: u32,
     distributions: Vec<Distribution>,
+    /// The range of supported Python versions.
+    requires_python: Option<VersionSpecifiers>,
     /// A map from distribution ID to index in `distributions`.
     ///
     /// This can be used to quickly lookup the full distribution for any ID
@@ -87,15 +89,18 @@ impl Lock {
             }
         }
 
-        let lock = Self::new(locked_dists.into_values().collect())?;
+        let distributions = locked_dists.into_values().collect();
+        let requires_python = graph.requires_python.clone();
+        let lock = Self::new(distributions, requires_python)?;
         Ok(lock)
     }
 
     /// Initialize a [`Lock`] from a list of [`Distribution`] entries.
-    fn new(distributions: Vec<Distribution>) -> Result<Self, LockError> {
+    fn new(distributions: Vec<Distribution>, requires_python: Option<VersionSpecifiers>) -> Result<Self, LockError> {
         let wire = LockWire {
             version: 1,
             distributions,
+            requires_python,
         };
         Self::try_from(wire)
     }
@@ -196,6 +201,7 @@ struct LockWire {
     version: u32,
     #[serde(rename = "distribution")]
     distributions: Vec<Distribution>,
+    requires_python: Option<VersionSpecifiers>,
 }
 
 impl From<Lock> for LockWire {
@@ -203,6 +209,7 @@ impl From<Lock> for LockWire {
         LockWire {
             version: lock.version,
             distributions: lock.distributions,
+            requires_python: lock.requires_python,
         }
     }
 }
@@ -215,6 +222,10 @@ impl Lock {
         let mut doc = toml_edit::DocumentMut::new();
         doc.insert("version", value(i64::from(self.version)));
 
+        if let Some(ref requires_python) = self.requires_python {
+            doc.insert("requires-python", value(requires_python.to_string()));
+        }
+
         let mut distributions = ArrayOfTables::new();
         for dist in &self.distributions {
             let mut table = Table::new();
@@ -344,6 +355,7 @@ impl TryFrom<LockWire> for Lock {
         Ok(Lock {
             version: wire.version,
             distributions: wire.distributions,
+            requires_python: wire.requires_python,
             by_id,
         })
     }
diff --git a/crates/uv-resolver/src/python_requirement.rs b/crates/uv-resolver/src/python_requirement.rs
index 0b8c2598ef44..e15c5c91b214 100644
--- a/crates/uv-resolver/src/python_requirement.rs
+++ b/crates/uv-resolver/src/python_requirement.rs
@@ -93,6 +93,14 @@ impl RequiresPython {
             }
         }
     }
+
+    /// Returns the [`VersionSpecifiers`] for the [`RequiresPython`] specifier.
+    pub fn as_specifiers(&self) -> Option<&VersionSpecifiers> {
+        match self {
+            RequiresPython::Specifier(_) => None,
+            RequiresPython::Specifiers(specifiers) => Some(specifiers),
+        }
+    }
 }
 
 impl std::fmt::Display for RequiresPython {
diff --git a/crates/uv-resolver/src/resolution/graph.rs b/crates/uv-resolver/src/resolution/graph.rs
index b63e4626bc95..8a066372dcea 100644
--- a/crates/uv-resolver/src/resolution/graph.rs
+++ b/crates/uv-resolver/src/resolution/graph.rs
@@ -9,7 +9,7 @@ use rustc_hash::{FxHashMap, FxHashSet};
 use distribution_types::{
     Dist, DistributionMetadata, Name, ResolutionDiagnostic, VersionId, VersionOrUrlRef,
 };
-use pep440_rs::{Version, VersionSpecifier};
+use pep440_rs::{Version, VersionSpecifier, VersionSpecifiers};
 use pep508_rs::{MarkerEnvironment, MarkerTree};
 use pypi_types::{ParsedUrlError, Yanked};
 use uv_git::GitResolver;
@@ -20,7 +20,8 @@ use crate::pubgrub::{PubGrubDistribution, PubGrubPackageInner};
 use crate::redirect::url_to_precise;
 use crate::resolution::AnnotatedDist;
 use crate::resolver::Resolution;
-use crate::{InMemoryIndex, Manifest, MetadataResponse, ResolveError, VersionsResponse};
+use crate::{InMemoryIndex, Manifest, MetadataResponse, PythonRequirement, ResolveError, VersionsResponse};
+use crate::python_requirement::RequiresPython;
 
 /// A complete resolution graph in which every node represents a pinned package and every edge
 /// represents a dependency between two pinned packages.
@@ -28,6 +29,8 @@ use crate::{InMemoryIndex, Manifest, MetadataResponse, ResolveError, VersionsRes
 pub struct ResolutionGraph {
     /// The underlying graph.
     pub(crate) petgraph: Graph<AnnotatedDist, Version, Directed>,
+    /// The range of supported Python versions.
+    pub(crate) requires_python: Option<VersionSpecifiers>,
     /// Any diagnostics that were encountered while building the graph.
     pub(crate) diagnostics: Vec<ResolutionDiagnostic>,
 }
@@ -39,9 +42,10 @@ impl ResolutionGraph {
         index: &InMemoryIndex,
         preferences: &Preferences,
         git: &GitResolver,
+        python: &PythonRequirement,
         resolution: Resolution,
     ) -> anyhow::Result<Self, ResolveError> {
-        // Collect all marker expressions from relevant pubgrub packages.
+        // Collect all marker expressions from relevant PubGrub packages.
         let mut markers: FxHashMap<(&PackageName, &Version, &Option<ExtraName>), MarkerTree> =
             FxHashMap::default();
         for (package, versions) in &resolution.packages {
@@ -267,8 +271,14 @@ impl ResolutionGraph {
             }
         }
 
+        // Extract the `Requires-Python` range, if provided.
+        // TODO(charlie): Infer the supported Python range from the `Requires-Python` of the
+        // included packages.
+        let requires_python = python.target().and_then(RequiresPython::as_specifiers).cloned();
+
         Ok(Self {
             petgraph,
+            requires_python,
             diagnostics,
         })
     }
diff --git a/crates/uv-resolver/src/resolver/mod.rs b/crates/uv-resolver/src/resolver/mod.rs
index 145cd580230a..a5635e74a572 100644
--- a/crates/uv-resolver/src/resolver/mod.rs
+++ b/crates/uv-resolver/src/resolver/mod.rs
@@ -557,7 +557,7 @@ impl<InstalledPackages: InstalledPackagesProvider> ResolverState<InstalledPackag
         for resolution in resolutions {
             combined.union(resolution);
         }
-        ResolutionGraph::from_state(&self.index, &self.preferences, &self.git, combined)
+        ResolutionGraph::from_state(&self.index, &self.preferences, &self.git, &self.python_requirement, combined)
     }
 
     /// Visit a [`PubGrubPackage`] prior to selection. This should be called on a [`PubGrubPackage`]
diff --git a/crates/uv/tests/lock.rs b/crates/uv/tests/lock.rs
index 795670a571a9..beb54ca3f73d 100644
--- a/crates/uv/tests/lock.rs
+++ b/crates/uv/tests/lock.rs
@@ -1038,6 +1038,7 @@ fn lock_requires_python() -> Result<()> {
         assert_snapshot!(
             lock, @r###"
         version = 1
+        requires-python = ">=3.7"
 
         [[distribution]]
         name = "dataclasses"