diff --git a/crates/uv-scripts/src/lib.rs b/crates/uv-scripts/src/lib.rs
index 470c452f83b2..5431a1e64994 100644
--- a/crates/uv-scripts/src/lib.rs
+++ b/crates/uv-scripts/src/lib.rs
@@ -5,10 +5,10 @@ use std::str::FromStr;
 use std::sync::LazyLock;
 
 use memchr::memmem::Finder;
-use pep440_rs::VersionSpecifiers;
 use serde::Deserialize;
 use thiserror::Error;
 
+use pep440_rs::VersionSpecifiers;
 use pep508_rs::PackageName;
 use pypi_types::VerbatimParsedUrl;
 use uv_settings::{GlobalOptions, ResolverInstallerOptions};
@@ -41,13 +41,14 @@ impl Pep723Script {
         };
 
         // Extract the `script` tag.
-        let Some(ScriptTag {
+        let ScriptTag {
             prelude,
             metadata,
             postlude,
-        }) = ScriptTag::parse(&contents)?
-        else {
-            return Ok(None);
+        } = match ScriptTag::parse(&contents) {
+            Ok(Some(tag)) => tag,
+            Ok(None) => return Ok(None),
+            Err(err) => return Err(err),
         };
 
         // Parse the metadata.
@@ -152,6 +153,8 @@ pub struct ToolUv {
 
 #[derive(Debug, Error)]
 pub enum Pep723Error {
+    #[error("An opening tag (`# /// script`) was found without a closing tag (`# ///`). Ensure that every line between the opening and closing tags (including empty lines) starts with a leading `#`.")]
+    UnclosedBlock,
     #[error(transparent)]
     Io(#[from] io::Error),
     #[error(transparent)]
@@ -272,7 +275,7 @@ impl ScriptTag {
         //
         // The latter `///` is the closing pragma
         let Some(index) = toml.iter().rev().position(|line| *line == "///") else {
-            return Ok(None);
+            return Err(Pep723Error::UnclosedBlock);
         };
         let index = toml.len() - index;
 
@@ -364,7 +367,7 @@ fn serialize_metadata(metadata: &str) -> String {
 
 #[cfg(test)]
 mod tests {
-    use crate::{serialize_metadata, ScriptTag};
+    use crate::{serialize_metadata, Pep723Error, ScriptTag};
 
     #[test]
     fn missing_space() {
@@ -374,7 +377,10 @@ mod tests {
             # ///
         "};
 
-        assert_eq!(ScriptTag::parse(contents.as_bytes()).unwrap(), None);
+        assert!(matches!(
+            ScriptTag::parse(contents.as_bytes()),
+            Err(Pep723Error::UnclosedBlock)
+        ));
     }
 
     #[test]
@@ -388,7 +394,10 @@ mod tests {
             # ]
         "};
 
-        assert_eq!(ScriptTag::parse(contents.as_bytes()).unwrap(), None);
+        assert!(matches!(
+            ScriptTag::parse(contents.as_bytes()),
+            Err(Pep723Error::UnclosedBlock)
+        ));
     }
 
     #[test]
diff --git a/crates/uv/tests/run.rs b/crates/uv/tests/run.rs
index d6e04fa99f01..f482aa8589ad 100644
--- a/crates/uv/tests/run.rs
+++ b/crates/uv/tests/run.rs
@@ -347,6 +347,30 @@ fn run_pep723_script() -> Result<()> {
       ╰─▶ Because there are no versions of add and you require add, we can conclude that your requirements are unsatisfiable.
     "###);
 
+    // If the script contains an unclosed PEP 723 tag, we should error.
+    let test_script = context.temp_dir.child("main.py");
+    test_script.write_str(indoc! { r#"
+        # /// script
+        # requires-python = ">=3.11"
+        # dependencies = [
+        #   "iniconfig",
+        # ]
+
+        # ///
+
+        import iniconfig
+       "#
+    })?;
+
+    uv_snapshot!(context.filters(), context.run().arg("--no-project").arg("main.py"), @r###"
+    success: false
+    exit_code: 2
+    ----- stdout -----
+
+    ----- stderr -----
+    error: An opening tag (`# /// script`) was found without a closing tag (`# ///`). Ensure that every line between the opening and closing tags (including empty lines) starts with a leading `#`.
+    "###);
+
     Ok(())
 }