diff --git a/crates/uv/src/cli.rs b/crates/uv/src/cli.rs
index 52b26bca515d..047d897c0861 100644
--- a/crates/uv/src/cli.rs
+++ b/crates/uv/src/cli.rs
@@ -532,17 +532,33 @@ pub(crate) struct PipCompileArgs {
     /// exit with an error.
     ///
     /// Alias for `--only-binary :all:`.
-    #[arg(long, conflicts_with = "only_binary", overrides_with = "build")]
+    #[arg(
+        long,
+        conflicts_with = "no_binary",
+        conflicts_with = "only_binary",
+        overrides_with("build")
+    )]
     pub(crate) no_build: bool,
 
     #[arg(
         long,
+        conflicts_with = "no_binary",
         conflicts_with = "only_binary",
         overrides_with("no_build"),
         hide = true
     )]
     pub(crate) build: bool,
 
+    /// Don't install pre-built wheels.
+    ///
+    /// The given packages will be installed from a source distribution. The resolver
+    /// will still use pre-built wheels for metadata.
+    ///
+    /// Multiple packages may be provided. Disable binaries for all packages with `:all:`.
+    /// Clear previously specified packages with `:none:`.
+    #[arg(long, conflicts_with = "no_build")]
+    pub(crate) no_binary: Option<Vec<PackageNameSpecifier>>,
+
     /// Only use pre-built wheels; don't build source distributions.
     ///
     /// When enabled, resolving will not run code from the given packages. The cached wheels of already-built
diff --git a/crates/uv/src/commands/pip/compile.rs b/crates/uv/src/commands/pip/compile.rs
index ec4722c91424..a8d56da048bc 100644
--- a/crates/uv/src/commands/pip/compile.rs
+++ b/crates/uv/src/commands/pip/compile.rs
@@ -81,6 +81,7 @@ pub(crate) async fn pip_compile(
     connectivity: Connectivity,
     no_build_isolation: bool,
     no_build: NoBuild,
+    no_binary: NoBinary,
     python_version: Option<PythonVersion>,
     python_platform: Option<TargetTriple>,
     exclude_newer: Option<ExcludeNewer>,
@@ -122,7 +123,7 @@ pub(crate) async fn pip_compile(
         extra_index_urls,
         no_index,
         find_links,
-        no_binary: _,
+        no_binary: specified_no_binary,
         no_build: specified_no_build,
     } = RequirementsSpecification::from_sources(
         requirements,
@@ -253,9 +254,10 @@ pub(crate) async fn pip_compile(
     let preferences = read_requirements_txt(output_file, &upgrade).await?;
     let git = GitResolver::default();
 
-    // Combine the `--no-build` flags.
+    // Combine the `--no-binary` and `--no-build` flags.
+    let no_binary = no_binary.combine(specified_no_binary);
     let no_build = no_build.combine(specified_no_build);
-    let build_options = BuildOptions::new(NoBinary::default(), no_build);
+    let build_options = BuildOptions::new(no_binary, no_build);
 
     // Resolve the flat indexes from `--find-links`.
     let flat_index = {
diff --git a/crates/uv/src/main.rs b/crates/uv/src/main.rs
index fbfefa0b9779..ce4987e1b721 100644
--- a/crates/uv/src/main.rs
+++ b/crates/uv/src/main.rs
@@ -241,6 +241,7 @@ async fn run() -> Result<ExitStatus> {
                 globals.connectivity,
                 args.pip.no_build_isolation,
                 args.pip.no_build,
+                args.pip.no_binary,
                 args.pip.python_version,
                 args.pip.python_platform,
                 args.pip.exclude_newer,
diff --git a/crates/uv/src/settings.rs b/crates/uv/src/settings.rs
index 01c542e1b486..d55d70dd679c 100644
--- a/crates/uv/src/settings.rs
+++ b/crates/uv/src/settings.rs
@@ -441,6 +441,7 @@ impl PipCompileSettings {
             build_isolation,
             no_build,
             build,
+            no_binary,
             only_binary,
             config_setting,
             python_version,
@@ -499,6 +500,7 @@ impl PipCompileSettings {
                     index_strategy,
                     keyring_provider,
                     no_build: flag(no_build, build),
+                    no_binary,
                     only_binary,
                     no_build_isolation: flag(no_build_isolation, build_isolation),
                     extra,
diff --git a/crates/uv/tests/pip_compile.rs b/crates/uv/tests/pip_compile.rs
index 195609531cee..343e70f24739 100644
--- a/crates/uv/tests/pip_compile.rs
+++ b/crates/uv/tests/pip_compile.rs
@@ -9764,3 +9764,47 @@ fn file_url() -> Result<()> {
 
     Ok(())
 }
+
+/// Allow `--no-binary` to override `--only-binary`, to allow select source distributions.
+#[test]
+fn no_binary_only_binary() -> Result<()> {
+    let context = TestContext::new("3.12");
+    let requirements_in = context.temp_dir.child("requirements.in");
+    requirements_in.write_str("source-distribution")?;
+
+    uv_snapshot!(context.compile_without_exclude_newer()
+        .arg("requirements.in")
+        .arg("--only-binary")
+        .arg(":all:"), @r###"
+    success: false
+    exit_code: 1
+    ----- stdout -----
+
+    ----- stderr -----
+      × No solution found when resolving dependencies:
+      ╰─▶ Because only source-distribution==0.0.1 is available and source-distribution==0.0.1 has no usable wheels and building from source is disabled, we can conclude that all versions of source-distribution cannot be used.
+          And because you require source-distribution, we can conclude that the requirements are unsatisfiable.
+    "###
+    );
+
+    uv_snapshot!(context.compile_without_exclude_newer()
+        .arg("requirements.in")
+        .arg("--only-binary")
+        .arg(":all:")
+        .arg("--no-binary")
+        .arg("source-distribution"), @r###"
+    success: true
+    exit_code: 0
+    ----- stdout -----
+    # This file was autogenerated by uv via the following command:
+    #    uv pip compile --cache-dir [CACHE_DIR] requirements.in --only-binary :all: --no-binary source-distribution
+    source-distribution==0.0.1
+        # via -r requirements.in
+
+    ----- stderr -----
+    Resolved 1 package in [TIME]
+    "###
+    );
+
+    Ok(())
+}