diff --git a/crates/distribution-filename/src/wheel.rs b/crates/distribution-filename/src/wheel.rs
index 5c6a5afef6ab..7017122cd636 100644
--- a/crates/distribution-filename/src/wheel.rs
+++ b/crates/distribution-filename/src/wheel.rs
@@ -5,7 +5,7 @@ use serde::{de, Deserialize, Deserializer, Serialize, Serializer};
 use thiserror::Error;
 use url::Url;
 
-use pep440_rs::{Version, VersionParseError};
+use pep440_rs::{Version, VersionParseError, VersionSpecifiers};
 use platform_tags::{TagCompatibility, Tags};
 use uv_normalize::{InvalidNameError, PackageName};
 
@@ -60,6 +60,59 @@ impl WheelFilename {
         compatible_tags.compatibility(&self.python_tag, &self.abi_tag, &self.platform_tag)
     }
 
+    /// Returns `false` if the wheel's tags state it can't be used in the given Python version
+    /// range.
+    ///
+    /// It is meant to filter out clearly unusable wheels with perfect specificity and acceptable
+    /// sensitivity, we return `true` if the tags are unknown.
+    pub fn matches_requires_python(&self, specifiers: &VersionSpecifiers) -> bool {
+        self.abi_tag.iter().any(|abi_tag| {
+            if abi_tag == "abi3" || abi_tag == "none" {
+                if self
+                    .python_tag
+                    .iter()
+                    .all(|python_tag| python_tag.starts_with("py2"))
+                {
+                    // Remove `py2-none-any` and `py27-none-any`.
+                    false
+                } else {
+                    // Universal tags are allowed.
+                    true
+                }
+            } else if abi_tag.starts_with("cp2") || abi_tag.starts_with("pypy2") {
+                // Python 2 is never allowed.
+                false
+            } else if let Some(minor_no_dot_abi) = abi_tag.strip_prefix("cp3") {
+                // Remove ABI tags, both old (dmu) and future (t, and all other letters).
+                let minor_not_dot = minor_no_dot_abi.trim_matches(char::is_alphabetic);
+                let Ok(minor) = minor_not_dot.parse::<u64>() else {
+                    // Unknown version pattern are allowed.
+                    return true;
+                };
+
+                let version = Version::new([3, minor]);
+                specifiers.contains(&version)
+            } else if let Some(minor_no_dot_abi) = abi_tag.strip_prefix("pypy3") {
+                // Given  `pypy39_pp73`, we just removed `pypy3`, now we remove `_pp73` ...
+                let Some((minor_not_dot, _)) = minor_no_dot_abi.split_once('_') else {
+                    // Unknown version pattern are allowed.
+                    return true;
+                };
+                // ... and get `9`.
+                let Ok(minor) = minor_not_dot.parse::<u64>() else {
+                    // Unknown version pattern are allowed.
+                    return true;
+                };
+
+                let version = Version::new([3, minor]);
+                specifiers.contains(&version)
+            } else {
+                // Unknown python tag -> allowed.
+                true
+            }
+        })
+    }
+
     /// The wheel filename without the extension.
     pub fn stem(&self) -> String {
         format!(
@@ -332,4 +385,36 @@ mod tests {
             );
         }
     }
+
+    #[test]
+    fn test_requires_python_included() {
+        let version_specifiers = VersionSpecifiers::from_str("==3.10.*").unwrap();
+        let wheel_names = &[
+            "bcrypt-4.1.3-cp37-abi3-macosx_10_12_universal2.whl",
+            "black-24.4.2-cp310-cp310-win_amd64.whl",
+            "cbor2-5.6.4-py3-none-any.whl",
+            "watchfiles-0.22.0-pp310-pypy310_pp73-macosx_11_0_arm64.whl",
+        ];
+        for wheel_name in wheel_names {
+            assert!(WheelFilename::from_str(wheel_name)
+                .unwrap()
+                .matches_requires_python(&version_specifiers));
+        }
+    }
+
+    #[test]
+    fn test_requires_python_dropped() {
+        let version_specifiers = VersionSpecifiers::from_str("==3.10.*").unwrap();
+        let wheel_names = &[
+            "PySocks-1.7.1-py27-none-any.whl",
+            "black-24.4.2-cp39-cp39-win_amd64.whl",
+            "psutil-6.0.0-cp36-cp36m-win32.whl",
+            "pydantic_core-2.20.1-pp39-pypy39_pp73-win_amd64.whl",
+        ];
+        for wheel_name in wheel_names {
+            assert!(!WheelFilename::from_str(wheel_name)
+                .unwrap()
+                .matches_requires_python(&version_specifiers));
+        }
+    }
 }
diff --git a/crates/uv-resolver/src/lock.rs b/crates/uv-resolver/src/lock.rs
index caec95b22017..6b13b0171486 100644
--- a/crates/uv-resolver/src/lock.rs
+++ b/crates/uv-resolver/src/lock.rs
@@ -190,6 +190,16 @@ impl Lock {
                     }
                 }
             }
+
+            // Remove wheels that don't match `requires-python` and can't be selected for
+            // installation.
+            if let Some(requires_python) = &requires_python {
+                dist.wheels.retain(|wheel| {
+                    wheel
+                        .filename
+                        .matches_requires_python(requires_python.specifiers())
+                });
+            }
         }
         distributions.sort_by(|dist1, dist2| dist1.id.cmp(&dist2.id));
 
diff --git a/crates/uv/tests/edit.rs b/crates/uv/tests/edit.rs
index d32909d7eb49..40f5e989e9b6 100644
--- a/crates/uv/tests/edit.rs
+++ b/crates/uv/tests/edit.rs
@@ -1373,36 +1373,6 @@ fn update() -> Result<()> {
         source = { registry = "https://pypi.org/simple" }
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diff --git a/crates/uv/tests/lock.rs b/crates/uv/tests/lock.rs
index 1e51f4f28358..7acecb70cbd6 100644
--- a/crates/uv/tests/lock.rs
+++ b/crates/uv/tests/lock.rs
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