diff --git a/docs/guides/integration/fastapi.md b/docs/guides/integration/fastapi.md
new file mode 100644
index 000000000000..7b31c29d06ae
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+++ b/docs/guides/integration/fastapi.md
@@ -0,0 +1,136 @@
+# Using uv with FastAPI
+
+[FastAPI](https://github.com/fastapi/fastapi) is modern, high-performance Python web framework. You
+can use uv to manage your FastAPI project, including installing dependencies, managing environments,
+running FastAPI applications, and more.
+
+!!! note
+
+    You can view the source code for this guide in the [uv-fastapi-example](https://github.com/astral-sh/uv-fastapi-example) repository.
+
+As an example, consider the sample application defined in the
+[FastAPI documentation](https://fastapi.tiangolo.com/tutorial/bigger-applications/), structured as
+follows:
+
+```plaintext
+.
+├── app
+│   ├── __init__.py
+│   ├── main.py
+│   ├── dependencies.py
+│   └── routers
+│   │   ├── __init__.py
+│   │   ├── items.py
+│   │   └── users.py
+│   └── internal
+│       ├── __init__.py
+│       └── admin.py
+```
+
+To migrate this project to uv, add a `pyproject.toml` file to the root directory of the project, as
+a sibling to the `app` directory.
+
+```plaintext
+.
+├── pyproject.toml
+├── app
+│   ├── __init__.py
+│   ├── main.py
+│   ├── dependencies.py
+│   └── routers
+│   │   ├── __init__.py
+│   │   ├── items.py
+│   │   └── users.py
+│   └── internal
+│       ├── __init__.py
+│       └── admin.py
+```
+
+The contents of the `pyproject.toml` file should look something like this:
+
+```toml title="pyproject.toml"
+[project]
+name = "app"
+version = "0.1.0"
+description = "FastAPI project"
+readme = "README.md"
+requires-python = ">=3.12"
+dependencies = [
+    "fastapi[standard]",
+]
+
+[build-system]
+requires = ["hatchling"]
+build-backend = "hatchling.build"
+```
+
+From there, you can run the FastAPI application with:
+
+```console
+$ uv run fastapi dev app/main.py
+```
+
+`uv run` will automatically resolve and lock the project dependencies (i.e., create a `uv.lock`
+alongside the `pyproject.toml`), create a virtual environment, and run the command in that
+environment.
+
+## Initializing a FastAPI project
+
+We could reach a similar result to the above by creating a project from scratch with `uv init` and
+installing FastAPI with `uv add fastapi`, as in:
+
+```console
+$ uv init app
+$ cd app
+$ uv add fastapi --extra standard
+```
+
+By default, uv uses a `src` layout for newly-created projects, so the `app` directory will be nested
+within a `src` directory. If you copied over the source code from the FastAPI tutorial, the project
+structure would look like this:
+
+```plaintext
+.
+├── pyproject.toml
+└── src
+    └── app
+        ├── __init__.py
+        ├── main.py
+        ├── dependencies.py
+        └── routers
+        │   ├── __init__.py
+        │   ├── items.py
+        │   └── users.py
+        └── internal
+            ├── __init__.py
+            └── admin.py
+```
+
+In this case, you would run the FastAPI application with:
+
+```console
+$ uv run fastapi dev src/app/main.py
+```
+
+## Deployment
+
+To deploy the FastAPI application with Docker, you can use the following `Dockerfile`:
+
+```dockerfile title="Dockerfile"
+FROM python:3.12-slim
+
+# Install uv.
+COPY --from=ghcr.io/astral-sh/uv:latest /uv /bin/uv
+
+# Copy the application into the container.
+COPY . /app
+
+# Install the application dependencies.
+WORKDIR /app
+RUN uv sync --frozen --no-cache
+
+# Run the application.
+CMD ["/app/.venv/bin/fastapi", "run", "app/main.py", "--port", "80"]
+```
+
+For more on using uv with Docker, see the [Docker guide](./docker.md).
diff --git a/mkdocs.template.yml b/mkdocs.template.yml
index 0805befdf192..6057adf9347c 100644
--- a/mkdocs.template.yml
+++ b/mkdocs.template.yml
@@ -113,6 +113,7 @@ nav:
       - Docker: guides/integration/docker.md
       - GitHub Actions: guides/integration/github.md
       - Pre-commit: guides/integration/pre-commit.md
+      - FastAPI: guides/integration/fastapi.md
       - Alternative indexes: guides/integration/alternative-indexes.md
   - The pip interface:
       - pip/index.md