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APOE in COVID-19

This repository contains the code to reproduce all figures from the manuscript

Common human genetic variants of APOE impact murine COVID-19 mortality, Nature, 2022

Benjamin N. Ostendorf†, Mira A. Patel, Jana Bilanovic, H.-Heinrich Hoffmann, Sebastian E. Carrasco, Charles M. Rice, Sohail F. Tavazoie†

Correspondence: bostendorf@rockefeller.edu, stavazoie@rockefeller.edu

doi: 10.1038/s41586-022-05344-2

Overview

Figures Code file R markdown output
- Fig1
- ED Fig 1
Fig_01/Fig_01.Rmd Fig_01/Fig_01.md
- Fig2
- ED Fig 2
Fig_02/Fig_02.Rmd Fig_02/Fig_02.md
- Fig 3b-c,
- ED Fig 3f-o
Fig_03/RNAseq/01_RNAseq.Rmd Fig_03/RNAseq/01_RNAseq.md
- ED Fig 3b-c Fig_03/RNAseq/02_RNAseq.Rmd Fig_03/RNAseq/02_RNAseq.md
- ED Fig 3d-e Fig_03/RNAseq/03_RNAseq.Rmd Fig_03/RNAseq/03_RNAseq.md
- Fig3d
- Fig3i
- ED Fig 4b
- ED Fig 4d-f
Fig_03/Fig_03d_03i.Rmd Fig_03/Fig_03d_03i.md
- Fig 3e-g
- ED Fig 5
- ED Fig 6
Fig_03/scRNAseq/Fig_03_scRNAseq.Rmd Fig_03/scRNAseq/Fig_03_scRNAseq.md
- ED Fig 3p Fig_03/ED_Fig_03p.Rmd Fig_03/ED_Fig_03p.md
- Fig 4
- ED Fig 7
- ED Fig 8
Fig_04/Fig_04.Rmd Fig_04/Fig_04.md

GEO upload for bulk RNA-seq (GSE184289)

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE184289

GEO upload for scRNA-seq (GSE199498)

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE199498