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Chaperones_Pan_DEGs.txt
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Chaperones_Pan_DEGs.txt
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rownames(chaperones_pan_degs_metalogFC_SD_with_description) Genes Feature meta_logFC SE SD SGD_name gene_biotype start_position end_position strand length chromosome_name Feature_definition Length Associated_process Condition Description
1 YAL005C SSA1 3.64275342141613 0.385189870206976 0.544740738535437 S000000004 ORF 139503 141431 -1 1929 I Stress-Seventy subfamily A 1929 Chaperones Chaperone-coding genes ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; required for ubiquitin-dependent degradation of short-lived proteins; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, cell wall; 98% identical to paralog Ssa2p with different functional specificity in propagation of yeast [URE3] prions, vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils [Source:SGD;Acc:S000000004]
2 YBL022C PIM1 2.2313805913158 0.0534205343452125 0.0755480441802173 S000000118 ORF 177874 181275 -1 3402 II Proteolysis In Mitochondria 3402 Chaperones Chaperone-coding genes ATP-dependent Lon protease; involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria [Source:SGD;Acc:S000000118]
3 YBL075C SSA3 3.95822676959374 0.329371141110552 0.465801134812846 S000000171 ORF 84499 86448 -1 1950 II Stress-Seventy subfamily A 1950 Chaperones Chaperone-coding genes ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication [Source:SGD;Acc:S000000171]
4 YBR072W HSP26 4.38482367515293 0.0286986130571525 0.0405859678067226 S000000276 ORF 382030 382674 1 645 II Heat Shock Protein 645 Chaperones Chaperone-coding genes Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic foci; oligomer activation requires heat-induced conformational change; also has mRNA binding activity [Source:SGD;Acc:S000000276]
5 YBR080C SEC18 2.48254986850207 0.0395486337593645 0.0559302142358197 S000000284 ORF 398614 400890 -1 2277 II SECretory 2277 Chaperones Chaperone-coding genes AAA ATPase and SNARE disassembly chaperone; required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian N-ethylmaleimide-sensitive factor (NSF) [Source:SGD;Acc:S000000284]
6 YBR091C TIM12 2.70005677740101 0.0227391585987262 0.0321580264872714 S000000295 ORF 427155 427484 -1 330 II Translocase of the Inner Membrane 330 Chaperones Chaperone-coding genes Essential protein of the inner mitochondrial membrane; peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins [Source:SGD;Acc:S000000295]
7 YBR173C UMP1 2.94426076534265 0.0720963757651962 0.101959672405087 S000000377 ORF 581726 582172 -1 447 II Ubiquitin-Mediated Proteolysis 447 Chaperones Chaperone-coding genes Chaperone required for correct maturation of the 20S proteasome; short-lived chaperone; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly [Source:SGD;Acc:S000000377]
8 YDL100C GET3 3.72207680145871 0.00517178242363769 0.00731400484515122 S000002258 ORF 282112 283176 -1 1065 IV Guided Entry of Tail-anchored proteins 1065 Chaperones Chaperone-coding genes Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; functions as a chaperone under ATP-depleted oxidative stress conditions; subunit of GET complex, involved in ATP dependent Golgi to ER trafficking and insertion of tail-anchored (TA) proteins into ER membrane under non-stress conditions; binds as dimer to transmembrane domain (TMD) cargo, shielding TMDs from aqueous solvent; protein abundance increases under DNA replication stress [Source:SGD;Acc:S000002258]
9 YDL110C TMA17 4.4404712835725 0.00569307640135808 0.00805122585842681 S000002268 ORF 264512 264964 -1 453 IV Translation Machinery Associated 453 Chaperones Chaperone-coding genes ATPase dedicated chaperone that adapts proteasome assembly to stress; Tma17p is induced upon stress; interacts with Rpt6p to assist its pairing to Rpt3p and early steps in proteasome biogenesis; associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion [Source:SGD;Acc:S000002268]
10 YDL120W YFH1 2.63995982292473 0.403711835500108 0.570934753054789 S000002278 ORF 245923 246447 1 525 IV Yeast Frataxin Homolog 525 Chaperones Chaperone-coding genes Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog FXN is mutated in Friedrich's ataxia; human FTL gene can complement yeast yfh1 null mutant [Source:SGD;Acc:S000002278]
11 YDR079W PET100 2.2048780253375 0.123000814294852 0.173949419758714 S000002486 ORF 603064 603399 1 336 IV PETite colonies 336 Chaperones Chaperone-coding genes Chaperone that facilitates the assembly of cytochrome c oxidase; integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme [Source:SGD;Acc:S000002486]
12 YDR161W ACL4 2.53855468033454 0.525080030932581 0.74257530107614 S000002568 ORF 779043 780206 1 1164 IV Assembly Chaperone of RpL4 1164 Chaperones Chaperone-coding genes Specific assembly chaperone for ribosomal protein Rpl4p; binds to an evolutionarily conserved surface extension of nascent Rpl4p and chaperones Rpl4p until its assembly into the pre-ribosome; transcriptionally co-regulated with rRNA and ribosome biosynthesis genes [Source:SGD;Acc:S000002568]
13 YDR171W HSP42 2.70947111759935 0.0378705862684721 0.0535570967158935 S000002578 ORF 806621 807748 1 1128 IV Heat Shock Protein 1128 Chaperones Chaperone-coding genes Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress [Source:SGD;Acc:S000002578]
14 YDR214W AHA1 2.51145114052009 0.083252816270758 0.117737261875861 S000002622 ORF 892875 893927 1 1053 IV Activator of Heat shock protein 90 ATPase 1053 Chaperones Chaperone-coding genes Co-chaperone that binds Hsp82p and activates its ATPase activity; plays a role in determining prion variants; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000002622]
15 YDR258C HSP78 2.15978611510341 0.0537715443050915 0.0760444472260061 S000002666 ORF 971808 974243 -1 2436 IV Heat Shock Protein 2436 Chaperones Chaperone-coding genes Oligomeric mitochondrial matrix chaperone; cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates [Source:SGD;Acc:S000002666]
16 YDR375C BCS1 2.4382202884487 0.0904691602833261 0.127942713449185 S000002783 ORF 1225166 1226536 -1 1371 IV ubiquinol-cytochrome c reductase (bc1) Synthesis 1371 Chaperones Chaperone-coding genes Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane and delivers it to an assembly intermediate of respiratory Complex III; also required for assembly of the Qcr10p subunit; mutation is functionally complemented by human homolog BCS1L, linked to neonatal diseases [Source:SGD;Acc:S000002783]
17 YDR493W MZM1 2.14091495883775 0.0770031753377443 0.108898934908431 S000002901 ORF 1436217 1436588 1 372 IV Mitochondrial Zinc Maintenance 372 Chaperones Chaperone-coding genes Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; member of the LYR protein family; human LYRM7 is a functional ortholog [Source:SGD;Acc:S000002901]
18 YEL020W-A TIM9 3.57485061167451 0.0147172061385648 0.0208132725213988 S000007256 ORF 117211 117474 1 264 V Translocase of the Inner Mitochondrial membrane 264 Chaperones Chaperone-coding genes Essential protein of the mitochondrial intermembrane space; forms a complex with Tim10p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane [Source:SGD;Acc:S000007256]
19 YEL030W ECM10 2.31421771426425 0.126047263943988 0.178257750169609 S000000756 ORF 94644 96578 1 1935 V ExtraCellular Mutant 1935 Chaperones Chaperone-coding genes Heat shock protein of the Hsp70 family; localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations; ECM10 has a paralog, SSC1, that arose from the whole genome duplication [Source:SGD;Acc:S000000756]
20 YER017C AFG3 3.25418398164696 0.0934584469802946 0.132170203237859 S000000819 ORF 189503 191788 -1 2286 V ATPase Family Gene 2286 Chaperones Chaperone-coding genes Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging; expression of human homolog AFG3L2 can complement yeast yta12 afg3 double mutant [Source:SGD;Acc:S000000819]
21 YER103W SSA4 4.40543031760333 0.518174239915657 0.732809037761092 S000000905 ORF 364589 366517 1 1929 V Stress-Seventy subfamily A 1929 Chaperones Chaperone-coding genes Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication [Source:SGD;Acc:S000000905]
22 YFL016C MDJ1 2.88709506588369 0.0540112881745369 0.0763834962576717 S000001878 ORF 104701 106236 -1 1536 VI Mitochondrial DnaJ 1536 Chaperones Chaperone-coding genes Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones [Source:SGD;Acc:S000001878]
23 YGL018C JAC1 2.04493561699658 0.00920408810635842 0.013016546229289 S000002986 ORF 459110 459664 -1 555 VII J-type Accessory Chaperone 555 Chaperones Chaperone-coding genes Specialized J-protein that functions in Fe-S cluster biogenesis; functions with Hsp70 in Fe-S cluster biogenesis in mitochondria; involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix [Source:SGD;Acc:S000002986]
24 YGR132C PHB1 2.25371874190321 0.189484626138505 0.267971728146269 S000003364 ORF 755589 756452 -1 864 VII ProHiBitin 864 Chaperones Chaperone-coding genes Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR) [Source:SGD;Acc:S000003364]
25 YGR231C PHB2 3.25450973613386 0.142566383470718 0.201619313042773 S000003463 ORF 952548 953480 -1 933 VII ProHiBitin 933 Chaperones Chaperone-coding genes Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR) [Source:SGD;Acc:S000003463]
26 YHR064C SSZ1 2.92990554110974 0.0450744315601972 0.0637448724286887 S000001106 ORF 225525 227141 -1 1617 VIII 1617 Chaperones Chaperone-coding genes Hsp70 protein that interacts with Zuo1p (a DnaJ homolog); interacts with Zuo1p to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP [Source:SGD;Acc:S000001106]
27 YJL034W KAR2 2.80545414529654 0.152749911723071 0.21602099681006 S000003571 ORF 381327 383375 1 2049 X KARyogamy 2049 Chaperones Chaperone-coding genes ATPase involved in protein import into the ER; also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p [Source:SGD;Acc:S000003571]
28 YJL054W TIM54 2.64292625062668 0.164872072144558 0.233164320483389 S000003590 ORF 334265 335701 1 1437 X Translocase of the Inner Mitochondrial membrane 1437 Chaperones Chaperone-coding genes Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane [Source:SGD;Acc:S000003590]
29 YJL104W PAM16 2.173894310285 0.136095162538534 0.192467624635366 S000003640 ORF 227327 227776 1 450 X Presequence translocase-Associated Motor 450 Chaperones Chaperone-coding genes Subunit of the import motor (PAM complex); the PAM complex is a component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain [Source:SGD;Acc:S000003640]
30 YJL143W TIM17 2.30216835338075 0.222732037024476 0.314990667535001 S000003679 ORF 147101 147577 1 477 X Translocase of the Inner Mitochondrial membrane 477 Chaperones Chaperone-coding genes Essential component of the TIM23 complex; with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core Translocase of the Inner Mitochondrial membrane (TIM23 complex) [Source:SGD;Acc:S000003679]
31 YJR135W-A TIM8 2.17553686114294 0.0669987658805919 0.0947505633705929 S000007348 ORF 676971 677234 1 264 X Translocase of the Inner Mitochondrial membrane 264 Chaperones Chaperone-coding genes Mitochondrial intermembrane space protein; forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome, also known as deafness-dystonia-optic neuronopathy (DDON) syndrome; human TIMM8A can complement yeast null mutant [Source:SGD;Acc:S000007348]
32 YKL117W SBA1 6.12474275677448 0.379275062075131 0.536375936656548 S000001600 ORF 220324 220974 1 651 XI increased Sensitivity to Benzoquinone Ansamycins 651 Chaperones Chaperone-coding genes Co-chaperone that binds and regulates Hsp90 family chaperones; plays a role in determining prion variants; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000001600]
33 YKR048C NAP1 5.04194879597295 0.513779964165763 0.726594593398785 S000001756 ORF 525387 526640 -1 1254 XI Nucleosome Assembly Protein 1254 Chaperones Chaperone-coding genes Histone chaperone; involved in histone exchange by removing and replacing histone H2A-H2B dimers or histone variant dimers from assembled nucleosomes; involved in the transport of H2A and H2B histones to the nucleus; required for the regulation of microtubule dynamics during mitosis; interacts with mitotic cyclin Clb2p; controls bud morphogenesis; phosphorylated by CK2; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000001756]
34 YLL024C SSA2 2.50803490006356 0.138593354436106 0.196000601498323 S000003947 ORF 95566 97485 -1 1920 XII Stress-Seventy subfamily A 1920 Chaperones Chaperone-coding genes HSP70 family ATP-binding protein; involved in protein folding, vacuolar import of proteins; required for ubiquitin-dependent degradation of short-lived proteins; associated with chaperonin-containing T-complex; 98% identical to paralog Ssa1p with distinct functional specificity in propagation of yeast [URE3] prions and vacuolar-mediated degradation of gluconeogenesis enzymes; binds tRNA, has role in tRNA nuclear import during starvation [Source:SGD;Acc:S000003947]
35 YLL026W HSP104 2.39979413590112 0.0254290681299243 0.0359621330278484 S000003949 ORF 88623 91349 1 2727 XII Heat Shock Protein 2727 Chaperones Chaperone-coding genes Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; potentiated Hsp104p variants decrease TDP-43 proteotoxicity by eliminating its cytoplasmic aggregation [Source:SGD;Acc:S000003949]
36 YLR008C PAM18 2.28182300455347 0.0974164019064094 0.137767596773632 S000003998 ORF 165577 166083 -1 507 XII Presequence translocase-Associated Motor 507 Chaperones Chaperone-coding genes Subunit of the import motor (PAM complex); the PAM complex is a component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p [Source:SGD;Acc:S000003998]
37 YLR021W IRC25 2.40515881872069 0.0268076237773482 0.0379117051209213 S000004011 ORF 183623 184162 1 540 XII Increased Recombination Centers 540 Chaperones Chaperone-coding genes Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; upregulates proteasome assembly in response to the unfolded protein response activated by mistargeting of proteins (UPRam) [Source:SGD;Acc:S000004011]
38 YLR216C CPR6 2.67971938195689 0.12276575228042 0.173616991869905 S000004206 ORF 572096 573211 -1 1116 XII Cyclosporin-sensitive Proline Rotamase 1116 Chaperones Chaperone-coding genes Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; plays a role in determining prion variants; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004206]
39 YLR259C HSP60 2.52743666992383 0.126211633618272 0.178490203992225 S000004249 ORF 663284 665002 -1 1719 XII Heat Shock Protein 1719 Chaperones Chaperone-coding genes Tetradecameric mitochondrial chaperonin; required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated [Source:SGD;Acc:S000004249]
40 YML028W TSA1 2.51578840068706 0.04353833389333 0.0615725022750754 S000004490 ORF 220138 220728 1 591 XIII Thiol-Specific Antioxidant 591 Chaperones Chaperone-coding genes Thioredoxin peroxidase; acts as both ribosome-associated and free cytoplasmic antioxidant; self-associates to form high-molecular weight chaperone complex under oxidative stress; chaperone activity essential for growth in zinc deficiency; required for telomere length maintenance; binds and modulates Cdc19p activity; protein abundance increases, forms cytoplasmic foci during DNA replication stress; TSA1 has a paralog, TSA2, that arose from the whole genome duplication [Source:SGD;Acc:S000004490]
41 YMR038C CCS1 4.3592407757161 0.534938076804333 0.756516683246468 S000004641 ORF 347511 348260 -1 750 XIII Copper Chaperone for SOD1 750 Chaperones Chaperone-coding genes Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within N-terminus is involved in insertion of copper into Sod1p under conditions of copper deprivation; required for regulation of yeast copper genes in response to DNA-damaging agents; protein abundance increases in response to DNA replication stress; human homolog CCS can complement yeast ccs1 null mutant [Source:SGD;Acc:S000004641]
42 YMR322C SNO4 2.91282136531879 0.085489779616176 0.120900805777483 S000004941 ORF 918366 919079 -1 714 XIII SNZ proximal Open reading frame 714 Chaperones Chaperone-coding genes Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation [Source:SGD;Acc:S000004941]
43 YNL070W TOM7 2.23379284020421 0.0368884522695678 0.0521681494945754 S000005014 ORF 493366 493548 1 183 XIV Translocase of the Outer Mitochondrial membrane 183 Chaperones Chaperone-coding genes Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex [Source:SGD;Acc:S000005014]
44 YNL206C RTT106 2.1934471220225 0.0380347185788092 0.053789214855196 S000005150 ORF 256788 258155 -1 1368 XIV Regulator of Ty1 Transposition 1368 Chaperones Chaperone-coding genes Histone chaperone; involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition; interacts physically and functionally with Chromatin Assembly Factor-1 (CAF-1) [Source:SGD;Acc:S000005150]
45 YNL209W SSB2 2.69777279776363 0.0217570243665681 0.0307690789360825 S000005153 ORF 252059 253900 1 1842 XIV Stress-Seventy subfamily B 1842 Chaperones Chaperone-coding genes Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication [Source:SGD;Acc:S000005153]
46 YNL246W VPS75 2.09595960781012 0.00780962404281427 0.0110444762383829 S000005190 ORF 185460 186349 1 890 XIV Vacuolar Protein Sorting 890 Chaperones Chaperone-coding genes NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000005190]
47 YNL281W HCH1 2.92963014626413 0.456015172667246 0.644902841833928 S000005225 ORF 108467 108928 1 462 XIV High-Copy Hsp90 suppressor 462 Chaperones Chaperone-coding genes Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; role in regulating Hsp90 inhibitor drug sensitivity; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000005225]
48 YNL310C ZIM17 2.76695058950684 0.45860376097008 0.648563658519197 S000005254 ORF 51907 52431 -1 525 XIV ZInc finger Motif protein of 17 kDa 525 Chaperones Chaperone-coding genes Protein co-chaperone with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix; required for the maintenance of Ssc1p solubility and assists in the functional interaction of Ssc1p with substrate proteins [Source:SGD;Acc:S000005254]
49 YNL328C MDJ2 2.45298584124478 0.0781261567251681 0.110487070416819 S000005272 ORF 22834 23274 -1 441 XIV Mitochondrial DnaJ homolog 441 Chaperones Chaperone-coding genes Constituent of the mitochondrial import motor; associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain [Source:SGD;Acc:S000005272]
50 YOR045W TOM6 2.79838319907486 0.0539063971287843 0.0762351579181968 S000005571 ORF 413852 414037 1 186 XV Translocase of the Outer Mitochondrial membrane 186 Chaperones Chaperone-coding genes Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex [Source:SGD;Acc:S000005571]
51 YPL098C MGR2 3.49094531651452 0.581999895315173 0.82307214525444 S000006019 ORF 364386 364727 -1 342 XVI Mitochondrial Genome Required 342 Chaperones Chaperone-coding genes Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; provides quality control for insertion of membrane proteins by regulating their release into the inner membrane by the TIM23 complex; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype) [Source:SGD;Acc:S000006019]
52 YPL131W RPL5 3.38370173440091 0.22611401936379 0.319773512826965 S000006052 ORF 303121 304014 1 894 XVI Ribosomal Protein of the Large subunit 894 Chaperones Chaperone-coding genes Ribosomal 60S subunit protein L5; nascent Rpl5p is bound by specific chaperone Syo1p during translation; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly [Source:SGD;Acc:S000006052]
53 YPL240C HSP82 2.33928605711688 0.0795701033325677 0.112529119292346 S000006161 ORF 96496 98625 -1 2130 XVI Heat Shock Protein 2130 Chaperones Chaperone-coding genes Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication [Source:SGD;Acc:S000006161]
54 YPR024W YME1 2.95458136139581 0.0260981513663987 0.036908359615227 S000006228 ORF 610481 612724 1 2244 XVI Yeast Mitochondrial Escape 2244 Chaperones Chaperone-coding genes Catalytic subunit of i-AAA protease complex; complex is located in mitochondrial inner membrane; responsible for degradation of unfolded or misfolded mitochondrial gene products; serves as nonconventional translocation motor to pull PNPase into intermembrane space; also has role in intermembrane space protein folding; mutation causes elevated rate of mitochondrial turnover; human homolog YME1L1 can complement yeast null mutant [Source:SGD;Acc:S000006228]