diff --git a/app/feature_defaults_unittest.cc b/app/feature_defaults_unittest.cc
index e83bc2df5a74..3f8aaad2f337 100644
--- a/app/feature_defaults_unittest.cc
+++ b/app/feature_defaults_unittest.cc
@@ -165,6 +165,7 @@ TEST(FeatureDefaultsTest, DisabledFeatures) {
       &features::kPrivacyGuidePreloadAndroid,
 #endif
       &features::kPrivacySandboxAdsAPIsOverride,
+      &features::kPrivacySandboxAdsAPIsM1Override,
 #if !BUILDFLAG(IS_ANDROID)
       &features::kReportPakFileIntegrity,
 #endif
diff --git a/chromium_src/content/common/features.cc b/chromium_src/content/common/features.cc
index f521efe56003..0acdf2f8404c 100644
--- a/chromium_src/content/common/features.cc
+++ b/chromium_src/content/common/features.cc
@@ -11,6 +11,8 @@
 namespace features {
 
 OVERRIDE_FEATURE_DEFAULT_STATES({{
+    // This feature should not be enabled when kFencedFrames is disabled.
+    {kPrivacySandboxAdsAPIsM1Override, base::FEATURE_DISABLED_BY_DEFAULT},
     {kResourceTimingForCancelledNavigationInFrame,
      base::FEATURE_DISABLED_BY_DEFAULT},
     {kServiceWorkerAutoPreload, base::FEATURE_DISABLED_BY_DEFAULT},
diff --git a/renderer/brave_content_renderer_client.cc b/renderer/brave_content_renderer_client.cc
index 9be541bbbe3c..f59060288a43 100644
--- a/renderer/brave_content_renderer_client.cc
+++ b/renderer/brave_content_renderer_client.cc
@@ -89,6 +89,9 @@ void BraveContentRendererClient::
       SetRuntimeFeaturesDefaultsBeforeBlinkInitialization();
 
   blink::WebRuntimeFeatures::EnableFledge(false);
+  // Disable topics APIs because kBrowsingTopics feature is disabled
+  blink::WebRuntimeFeatures::EnableTopicsAPI(false);
+  blink::WebRuntimeFeatures::EnableTopicsDocumentAPI(false);
   blink::WebRuntimeFeatures::EnableWebGPUExperimentalFeatures(false);
   blink::WebRuntimeFeatures::EnableWebNFC(false);
 
diff --git a/test/filters/browser_tests.filter b/test/filters/browser_tests.filter
index 7efd44977089..d3823c22bb8a 100644
--- a/test/filters/browser_tests.filter
+++ b/test/filters/browser_tests.filter
@@ -260,6 +260,7 @@
 -ExternalProtocolHandlerSandboxFencedFrameBrowserTest.SandboxAllowTopNavigationByUserActivationWithGestureInFencedFrame
 -PrivacySandboxSettingsAdsApisFlagBrowserTest.FollowsOverrideBehavior
 -SharedStorageChromeContextOriginByDefaultDisabledBrowserTest.*
+-SharedStorageChromeCrossOriginScriptDisabledBrowserTest.AddModule_CrossOriginScriptError
 -SharedStorageExtensionBrowserTest.*
 -SharedStorageFencedFrameChromeBrowserTest.*
 
@@ -831,12 +832,26 @@
 -WebViewTests/WebViewTest.DownloadCookieIsolation_CrossSession/SiteIsolationForGuestsEnabled
 
 # These tests fail because we intentionally disable fenced frames via
-# blink::features::kFencedFrames
+# blink::features::kFencedFrames and 
 -AccessContextAuditFencedFrameBrowserTest.*
+-All/HostedAppProcessModelFencedFrameTest.FencedFrameHasDifferentSiteInstance/0
 -All/IntentPickerBubbleViewFencedFrameBrowserTest.*
 -All/IntentPickerIconFencedFrameBrowserTest.ShouldShowIntentPickerInFencedFrame/*
+-All/PaintPreviewFencedFrameBrowserTest.*
+-All/PDFExtensionPrerenderAndFencedFrameTest.*
 -All/SafeBrowsingFencedFrameBrowserTest.*
+-All/SecurityStateTabHelperFencedFrameTest.*
+-AmpPageLoadMetricsFencedFrameBrowserTest.AmpFencedFrame
+-AppBannerManagerFencedFrameBrowserTest.FencedFrameShouldNotUpdateState
+-AutoplayPolicyFencedFrameTest.AutoplayAllowedByPolicy
+-AutoplayPolicyFencedFrameTest.AutoplayAllowlist_Allowed
 -BackgroundFetchFencedFrameBrowserTest.*
+-ChromeAppAPIFencedFrameTest.NoInfo
+-ChromeRegisterProtocolHandlerBrowserTest.FencedFrame
+-CommerceHintAgentFencedFrameTest.VisitCartInFencedFrame
+-ComposeEnablingWithFencedFramesBrowserTest.DisabledInFencedFrames
+-ContentScriptApiFencedFrameTest.InjectionMatchesCorrectExtension
+-ContentSettingsWithFencedFrameBrowserTest.FencedFrameSetsCookie
 -ContentSettingsWithFencedFrameBrowserTest.NestedFramesRendererContentSettings
 -ContentSettingsWithFencedFrameBrowserTest.RendererContentSettings
 -ContentSettingsWithFencedFrameBrowserTest.StorageAccessInFencedFrame
@@ -846,20 +861,76 @@
 -ContextMenuFencedFrameTest.Save*
 -ContextMenuFencedFrameTestNoTestingConfig.AutomaticBeaconSentAfterContextMenuNavigation
 -DeclarativeNetRequestApiFencedFrameTest/DeclarativeNetRequestApiFencedFrameTest.*
+-ExecuteScriptApiFencedFrameTest.Load
+-ExtensionActionRunnerFencedFrameBrowserTest.DoNotResetExtensionActionRunner
+-ExtensionActionRunnerFencedFrameBrowserTest.FencedFrameDoesNotClearActiveExtensions
 -ExtensionWebRequestApiFencedFrameTest.DeclarativeSendMessage
 -ExtensionWebRequestApiFencedFrameTest/ExtensionWebRequestApiFencedFrameTest.*
+-ExtensionWebRequestApiFencedFrameTest.Load
+-ExternalProtocolHandlerSandboxFencedFrameBrowserTest.*
+-FencedFrameDownloadTest.DownloadRequestLimiterIsUnaffectedByFencedFrame
+-FencedFrameDownloadTest.FencedFrameSandboxFlagBlockDownload
+-FencedFrameDownloadTest.NetworkCutoffBlockSaveImageAs
+-FencedFrameFileSystemAccessBrowserTest.RequestWriteAccess
 -FencedFrameLoadingPredictorBrowserTest.*
+-FencedFrameReduceAcceptLanguageBrowserTest.CrossOriginFencedFrame
+-FencedFrameReduceAcceptLanguageBrowserTest.SameOriginFencedFrame
 -FencedFrameSiteDetailsBrowserTest.*
+-FencedFrameTaskBrowserTest.*
+-FencedFrameTaskBrowserTestNoTestingConfig.ProperlyShowsTasks
+-FramebustBlockFencedFrameTest.FramebustBlocked_FencedFrameNavigation
+-HistoryFencedFrameBrowserTest.FencedFrameDoesNotAffectLoadingState
+-InsecureFormNavigationThrottleFencedFrameBrowserTest.DoNotCreateSecurityInterstitialInFencedFrame
 -InspectUIFencedFrameTest.*
+-LoginDetectionFencedFrameBrowserTest.FencedFrameShouldNotRecordLoginDetectionMetrics
+-MediaEngagementContentsObserverFencedFrameBrowserTest.SendEngagementLevelToRenderFrameOnFencedFrame
 -MessagingApiFencedFrameTest.Load
 -MessagingApiFencedFrameTest/MessagingApiFencedFrameTest.*
+-MixedContentSettingsTabHelperFencedFrameBrowserTest.IgnoreInsecureContentInFencedFrame
+-NavigationPredictorFencedFrameBrowserTest.EnsureFencedFrameDoesNotCreateNavigationPredictor
+-NetErrorTabHelperWithFencedFrameTest.CanRunDiagnosticsDialogOnFencedFrame
+-NewTabPageNavigationThrottleFencedFrameTest.FencedFrameShouldNotAffectTitle
+-NoStatePrefetchFencedFrameBrowserTest.ShouldNotRecordNavigation
+-PageLoadMetricsBrowserTestWithFencedFrames.PageLoadPrivacySandboxAdsFencedFramesMetrics
+-PageLoadMetricsObserverFencedFrameBrowserTest.FencedFrameCountsAsSubFramePageLoad
+-PageTextObserverFencedFrameBrowserTest.DoNotDispatchResponseOnFencedFrame
 -PerformanceHintsObserverFencedFrameTest.*
+-PermissionRequestManagerWithFencedFrameTest.GetCurrentPosition
+-PermissionRequestManagerWithFencedFrameTest.RequestPermissionThruDelegate
+-PictureInPictureWindowControllerFencedFrameBrowserTest.FencedFrameShouldNotCloseWindow
+-PlatformAppNavigationRedirectorFencedFrameBrowserTest.DoNotLaunchAppInFencedFrames
 -PrefetchProxyFencedFrameBrowserTest.*
+-PrintFencedFrameBrowserTest.DocumentExecCommand
+-PrintFencedFrameBrowserTest.ScriptedPrint
+-SBNavigationObserverBrowserTest.FencedFrameNavigationEventsAndReferrerChain
 -SigninReauthViewControllerFencedFrameBrowserTest.*
+-SSLFencedFrameBrowserTest.CertErrorInFencedFrame
+-SSLFencedFrameBrowserTest.InAppTestProceededBadCertPageInFencedFrame
+-SafeBrowsingTriggeredPopupBlockerFencedFrameBrowserTest.ShouldNotTriggerPopupBlocker
+-SafeBrowsingTriggeredPopupBlockerFencedFrameBrowserTest.ShouldTriggerPopupBlocker
+-SameOriginObserverFencedFrameTest.FFDoesNotAffectSameOriginState
+-SecurityStatePageLoadMetricsFencedFrameBrowserTest.DoNotRecordOnCommitSecurityLevelHistogram
+-SoundContentSettingObserverFencedFrameBrowserTest.AddAutoplayFlagsInFencedFrame
+-SubresourceFilterFencedFrameBrowserTest.CollapseBlockedFencedFrame
+-SubresourceFilterFencedFrameBrowserTest.FencedFrameLoadFiltering
+-SubresourceFilterFencedFrameBrowserTest.LoadFilteringNestedInFencedFrame
+-SubresourceFilterFencedFrameBrowserTest.NavigatesToURLWithWarning_NoMessageLogged
+-SubresourceFilterFencedFrameBrowserTest.OutermostFrameActivation
 -TabContentsTagFencedFrameTest.FencedFrameDoesNotUpdateTitle
+-TabManagerFencedFrameTest.TabManagerWasDiscarded
+-TabStatsTrackerSubFrameBrowserTest.VerifyBehaviorOnSubFrameNavigation
+-TabUnderBlockerFencedFrameTest.RedirectAfterGesture_WithFF_IsNotBlocked
+-TabUnderBlockerFencedFrameTest.SimpleTabUnder_WithFencedFrame_IsBlocked
+-TrustedVaultEncryptionKeysTabHelperBrowserTest.ShouldBindClientEncryptionKeysApiInFencedFrame
+-TrustedVaultEncryptionKeysTabHelperBrowserTest.ShouldBindSyncEncryptionKeysApiInFencedFrame
+-WebAuthFlowFencedFrameTest.FencedFrameNavigationFailure
+-WebAuthFlowFencedFrameTest.FencedFrameNavigationSuccess
 -WebNavigationApiFencedFrameTest.Load
 -WebNavigationApiFencedFrameTest/WebNavigationApiFencedFrameTest.*
+-WebViewTests/WebViewFencedFrameTest.FencedFrameInGuestHasGuestSiteInstance/IsolateFencedFramesDisabled
+-WebViewTests/WebViewFencedFrameTest.FencedFrameInGuestHasGuestSiteInstance/IsolateFencedFramesEnabled
 -WebViewTests/WebViewFencedFrameTest.FencedFrameInGuestHasGuestSiteInstance/SiteIsolationForGuestsEnabled
+-WebViewWithDefaultSiteInstanceTest.FencedFrame
 
 # These tests fail because we skip amp pages with deamp
 -AMPPageLoadMetricsObserverTest.*