You signed in with another tab or window. Reload to refresh your session.You signed out in another tab or window. Reload to refresh your session.You switched accounts on another tab or window. Reload to refresh your session.Dismiss alert
Currently one can do a group comparison of pre and post treatment cases, but it is hard to identify resistance mutations. You can e.g. compare tumors sequenced before and after crizotinib treatment. OncoKB will clearly show ALK resistance missense mutations in the after group. In the before treatment group you will find ALK fusion mutations, but in the post group it would be ALK fusions + resistance missense mutations. Ideally we can compare by individual mutations on the comparison page somehow:
show some lollipop plot for multiple groups
make the user interaction flow to the query results page easier from the comparison page, so one can see the oncoprint/mutations tab with less clicks.
Note that this particular case can also be solved by having the fusions in a separate tab from mutations (this is already the case i believe, so would be a matter of loading the data properly)
This discussion was converted from issue #7879 on April 26, 2021 16:17.
Heading
Bold
Italic
Quote
Code
Link
Numbered list
Unordered list
Task list
Attach files
Mention
Reference
Menu
reacted with thumbs up emoji reacted with thumbs down emoji reacted with laugh emoji reacted with hooray emoji reacted with confused emoji reacted with heart emoji reacted with rocket emoji reacted with eyes emoji
-
Currently one can do a group comparison of pre and post treatment cases, but it is hard to identify resistance mutations. You can e.g. compare tumors sequenced before and after crizotinib treatment. OncoKB will clearly show ALK resistance missense mutations in the after group. In the before treatment group you will find ALK fusion mutations, but in the post group it would be ALK fusions + resistance missense mutations. Ideally we can compare by individual mutations on the comparison page somehow:
Note that this particular case can also be solved by having the fusions in a separate tab from mutations (this is already the case i believe, so would be a matter of loading the data properly)
Beta Was this translation helpful? Give feedback.
All reactions