diff --git a/.github/workflows/integration_test_charm.yaml b/.github/workflows/integration_test_charm.yaml
index 17514b0d..6f559d62 100644
--- a/.github/workflows/integration_test_charm.yaml
+++ b/.github/workflows/integration_test_charm.yaml
@@ -13,8 +13,16 @@ on:
           Use canonical/data-platform-workflows build_charm.yaml to build the charm(s)
         required: true
         type: string
+      architecture:
+        # Keep description synchronized with "Parse architecture input" step
+        description: |
+          Processor architecture
+          
+          Must be one of "amd64", "arm64"
+        default: amd64
+        type: string
       cloud:
-        # Keep description synchronized with "Validate input" step
+        # Keep description synchronized with "Parse cloud input" step
         description: |
           Juju cloud
 
@@ -102,13 +110,34 @@ jobs:
     # ci.yaml will not show up on the GitHub Actions sidebar.
     # If this workflow is called with a matrix (e.g. to test multiple juju versions), the ci.yaml
     # job name containing the Juju version will be lost.
-    # So, we add the Juju version to one of the first jobs in this workflow.
+    # So, we add the Juju version & architecture to one of the first jobs in this workflow.
     # (In the UI, when this workflow is called with a matrix, GitHub will separate each matrix
     # combination and preserve job ordering within a matrix combination.)
-    name: ${{ inputs.juju-agent-version || inputs.juju-snap-channel }} | Collect integration test groups
+    name: ${{ inputs.juju-agent-version || inputs.juju-snap-channel }} | ${{ inputs.architecture }} | Collect integration test groups
     runs-on: ubuntu-latest
     timeout-minutes: 5
     steps:
+      - name: Parse architecture input
+        id: parse-architecture
+        shell: python
+        # Keep synchronized with inputs.architecture description
+        run: |
+          import json
+          import os
+          
+          DEFAULT_RUNNERS = {
+              "amd64": "ubuntu-latest",
+              "arm64": "Ubuntu_ARM64_4C_16G_01",
+          }
+          ARCHITECTURE = "${{ inputs.architecture }}"
+          try:
+              default_runner = DEFAULT_RUNNERS[ARCHITECTURE]
+          except KeyError:
+              raise ValueError(f"`architecture` input not recognized: {ARCHITECTURE}")
+          output = f"default_runner={json.dumps(default_runner)}"
+          print(output)
+          with open(os.environ["GITHUB_OUTPUT"], "a") as file:
+              file.write(output)
       - name: Checkout
         uses: actions/checkout@v4
       - name: Install tox & poetry
@@ -135,6 +164,7 @@ jobs:
         run: tox run -e integration -- tests/integration -m '${{ steps.select-test-stability.outputs.mark_expression }}' --collect-groups
     outputs:
       groups: ${{ steps.collect-groups.outputs.groups }}
+      default_runner: ${{ steps.parse-architecture.outputs.default_runner }}
 
   integration-test:
     strategy:
@@ -145,11 +175,11 @@ jobs:
     needs:
       - get-workflow-version
       - collect-integration-tests
-    runs-on: ${{ matrix.groups.runner || 'ubuntu-latest' }}
+    runs-on: ${{ matrix.groups.runner || fromJSON(needs.collect-integration-tests.outputs.default_runner) }}
     timeout-minutes: 120
     steps:
       - name: Free up disk space
-        if: ${{ !matrix.groups.self_hosted }}
+        if: ${{ !(inputs.architecture == 'arm64' || matrix.groups.self_hosted) }}
         run: |
           printf '\nDisk usage before cleanup\n'
           df --human-readable
@@ -159,10 +189,13 @@ jobs:
           printf '\nDisk usage after cleanup\n'
           df --human-readable
       - name: (self-hosted) Disk usage
-        if: ${{ matrix.groups.self_hosted }}
+        if: ${{ inputs.architecture == 'arm64' || matrix.groups.self_hosted }}
         run: df --human-readable
+      - name: (arm64 GitHub-hosted) Link python to python3
+        if: ${{ inputs.architecture == 'arm64' && !matrix.groups.self_hosted }}
+        run: sudo ln -s /usr/bin/python3 /usr/bin/python
       - name: (self-hosted) Install pipx
-        if: ${{ matrix.groups.self_hosted }}
+        if: ${{ inputs.architecture == 'arm64' || matrix.groups.self_hosted }}
         run: |
           sudo apt-get update
           sudo apt-get install python3-pip python3-venv -y
@@ -275,6 +308,11 @@ jobs:
           juju add-model test
           pipx install tox
           pipx install poetry
+      - name: Add architecture model constraint
+        if: ${{ inputs.cloud == 'lxd' }}
+        # Unable to set constraint on all models because of Juju bug:
+        # https://bugs.launchpad.net/juju/+bug/2065050
+        run: juju set-model-constraints arch='${{ inputs.architecture }}'
       - name: Update python-libjuju version
         if: ${{ inputs.libjuju-version-constraint }}
         run: poetry add --lock --group integration juju@'${{ inputs.libjuju-version-constraint }}'
@@ -319,7 +357,7 @@ jobs:
         if: ${{ (success() || (failure() && steps.tests.outcome == 'failure')) && inputs._beta_allure_report && github.event_name == 'schedule' && github.run_attempt == '1' }}
         uses: actions/upload-artifact@v4
         with:
-          name: allure-results-integration-test-charm-${{ inputs.cloud }}-juju-${{ inputs.juju-agent-version || steps.parse-versions.outputs.snap_channel_for_artifact }}-${{ matrix.groups.artifact_group_id }}
+          name: allure-results-integration-test-charm-${{ inputs.cloud }}-juju-${{ inputs.juju-agent-version || steps.parse-versions.outputs.snap_channel_for_artifact }}-${{ inputs.architecture }}-${{ matrix.groups.artifact_group_id }}
           path: allure-results/
           if-no-files-found: error
       - name: Select model
@@ -348,7 +386,7 @@ jobs:
         if: ${{ success() || (failure() && steps.tests.outcome == 'failure') }}
         uses: actions/upload-artifact@v4
         with:
-          name: logs-intergration-test-charm-${{ inputs.cloud }}-juju-${{ inputs.juju-agent-version || steps.parse-versions.outputs.snap_channel_for_artifact }}-${{ matrix.groups.artifact_group_id }}
+          name: logs-intergration-test-charm-${{ inputs.cloud }}-juju-${{ inputs.juju-agent-version || steps.parse-versions.outputs.snap_channel_for_artifact }}-${{ inputs.architecture }}-${{ matrix.groups.artifact_group_id }}
           path: ~/logs/
           if-no-files-found: error
       - name: Disk usage
@@ -393,7 +431,7 @@ jobs:
         uses: actions/download-artifact@v4
         with:
           path: allure-results/
-          pattern: allure-results-integration-test-charm-${{ inputs.cloud }}-juju-${{ inputs.juju-agent-version || needs.integration-test.outputs.juju-snap-channel-for-artifact }}-*
+          pattern: allure-results-integration-test-charm-${{ inputs.cloud }}-juju-${{ inputs.juju-agent-version || needs.integration-test.outputs.juju-snap-channel-for-artifact }}-${{ inputs.architecture }}-*
           merge-multiple: true
       - name: Load test report history
         run: |
diff --git a/python/pytest_plugins/pytest_operator_cache/pytest_operator_cache/_plugin.py b/python/pytest_plugins/pytest_operator_cache/pytest_operator_cache/_plugin.py
index 06f7cd30..f7e1b26d 100644
--- a/python/pytest_plugins/pytest_operator_cache/pytest_operator_cache/_plugin.py
+++ b/python/pytest_plugins/pytest_operator_cache/pytest_operator_cache/_plugin.py
@@ -1,5 +1,6 @@
 import os
 import pathlib
+import subprocess
 import typing
 
 import yaml
@@ -22,17 +23,31 @@ async def build_charm(
     self, charm_path: typing.Union[str, os.PathLike], bases_index: int = None
 ) -> pathlib.Path:
     charm_path = pathlib.Path(charm_path)
-    # TODO: add support for multiple architectures
+    architecture = subprocess.run(
+        ["dpkg", "--print-architecture"],
+        capture_output=True,
+        check=True,
+        encoding="utf-8",
+    ).stdout.strip()
+    assert architecture in ("amd64", "arm64")
     if bases_index is not None:
         charmcraft_yaml = yaml.safe_load((charm_path / "charmcraft.yaml").read_text())
         assert charmcraft_yaml["type"] == "charm"
         base = charmcraft_yaml["bases"][bases_index]
         # Handle multiple base formats
         # See https://discourse.charmhub.io/t/charmcraft-bases-provider-support/4713
-        version = base.get("build-on", [base])[0]["channel"]
-        packed_charms = list(charm_path.glob(f"*{version}-amd64.charm"))
+        build_on = base.get("build-on", [base])[0]
+        version = build_on["channel"]
+        architectures = build_on.get("architectures", ["amd64"])
+        assert (
+            len(architectures) == 1
+        ), f"Multiple architectures ({architectures}) in one (charmcraft.yaml) base not supported. Use one base per architecture"
+        assert (
+            architectures[0] == architecture
+        ), f"Architecture for {bases_index=} ({architectures[0]}) does not match host architecture ({architecture})"
+        packed_charms = list(charm_path.glob(f"*{version}-{architecture}.charm"))
     else:
-        packed_charms = list(charm_path.glob("*-amd64.charm"))
+        packed_charms = list(charm_path.glob(f"*-{architecture}.charm"))
     if len(packed_charms) == 1:
         # python-libjuju's model.deploy(), juju deploy, and juju bundle files expect local charms
         # to begin with `./` or `/` to distinguish them from Charmhub charms.
@@ -43,13 +58,11 @@ async def build_charm(
         # `pathlib.Path`.)
         return packed_charms[0].resolve(strict=True)
     elif len(packed_charms) > 1:
-        message = f"More than one matching .charm file found at {charm_path=}: {packed_charms}."
+        message = f"More than one matching .charm file found at {charm_path=} for {architecture=}: {packed_charms}."
         if bases_index is None:
             message += " Specify `bases_index`"
-        else:
-            message += " Does charmcraft.yaml contain non-amd64 architecture?"
         raise ValueError(message)
     else:
         raise ValueError(
-            f"Unable to find amd64 .charm file for {bases_index=} at {charm_path=}"
+            f"Unable to find .charm file for {architecture=} and {bases_index=} at {charm_path=}"
         )