diff --git a/packages/react/src/components/MultiSelect/MultiSelect.js b/packages/react/src/components/MultiSelect/MultiSelect.js
index 392bc95476c3..aa148aa2cb46 100644
--- a/packages/react/src/components/MultiSelect/MultiSelect.js
+++ b/packages/react/src/components/MultiSelect/MultiSelect.js
@@ -190,6 +190,9 @@ const MultiSelect = React.forwardRef(function MultiSelect(
       case ItemClick:
       case MenuKeyDownSpaceButton:
       case MenuKeyDownEnter:
+        if (changes.selectedItem === undefined) {
+          break;
+        }
         onItemChange(changes.selectedItem);
         break;
       case MenuKeyDownArrowDown: