example_medline_input.txt

PMID- 26973276
OWN - NLM
STAT- MEDLINE
DA  - 20160323
DCOM- 20160802
LR  - 20160323
IS  - 1349-3299 (Electronic)
IS  - 1349-2365 (Linking)
VI  - 57
IP  - 2
DP  - 2016
TI  - Aortic Stenosis in a Patient With Sjogren's Syndrome.
PG  - 251-3
LID - 10.1536/ihj.15-349 [doi]
AB  - Sjogren's syndrome (SS) is an autoimmune disease characterized by dryness of the 
      mouth and the eyes. Systemic involvement in SS is well known, however, obvious
      cardiac manifestations, particularly significant valve disorders, are extremely
      rare and only three cases of significant valve disease associated with SS that
      required surgical intervention have been previously described. We report a case
      of aortic stenosis (AS) associated with SS in an elderly patient. The diagnosis
      of primary SS had been made based on clinical features, positive ocular signs,
      and positive serologic findings. Echocardiography showed severe calcification,
      elevated mean pressure gradient (57 mmHg), and a small orifice area (0.45 cm(2)) 
      of the aortic valve. At surgery, severe calcification of the aortic cusps and the
      annulus was the mechanism of AS, and the aortic valve was replaced with a
      bioprosthetic valve. Valve pathology showed nodular calcification and hyaline
      degeneration, but lymphocyte infiltration was not evident. The etiologic relation
      of SS to the valve lesions is not clear pathologically in this case, however,
      chronic inflammation related to immunologic reactions in SS could have some
      effect on exacerbation for degeneration of the valve tissue.
FAU - Kono, Michitaka
AU  - Kono M
AD  - Department of Cardiovascular Surgery, Munakata Suikokai General Hospital.
FAU - Aoyagi, Shigeaki
AU  - Aoyagi S
FAU - Okazaki, Teiji
AU  - Okazaki T
FAU - Tayama, Kei-Ichiro
AU  - Tayama K
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20160311
PL  - Japan
TA  - Int Heart J
JT  - International heart journal
JID - 101244240
SB  - IM
MH  - Aged
MH  - Aortic Valve Stenosis/diagnosis/*etiology/surgery
MH  - *Bioprosthesis
MH  - Echocardiography
MH  - Female
MH  - Heart Valve Prosthesis Implantation/*methods
MH  - Humans
MH  - Severity of Illness Index
MH  - Sjogren's Syndrome/*complications/diagnosis
EDAT- 2016/03/15 06:00
MHDA- 2016/08/03 06:00
CRDT- 2016/03/15 06:00
AID - 10.1536/ihj.15-349 [doi]
PST - ppublish
SO  - Int Heart J. 2016;57(2):251-3. doi: 10.1536/ihj.15-349. Epub 2016 Mar 11.