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DESCRIPTION
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DESCRIPTION
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Package: DoubletFinder
Type: Package
Title: DoubletFinder is a suite of tools for identifying doublets in single-cell RNA sequencing data.
Version: 2.0.4
Author: person("Chris", "McGinnis", email = "cmcginni92@gmail.com", role = c("aut","cre"))
Imports: fields, KernSmooth, ROCR, parallel
Maintainer: <cmcginni92@gmail.com>
Description: DoubletFinder identifies doublets by generating artificial doublets from existing scRNA-seq data and defining which real cells preferentially co-localize with artificial doublets in gene expression space. Other DoubletFinder package functions are used for fitting DoubletFinder to different scRNA-seq datasets. For example, ideal DoubletFinder performance in real-world contexts requires (I) Optimal pK selection and (2) Homotypic doublet proportion estimation. pK selection is achieved using pN-pK parameter sweeps and maxima identification in mean-variance-normalized bimodality coefficient distributions. Homotypic doublet proportion estimation is achieved by finding the sum of squared cell annotation frequencies. For more information, see our Cell Sysmtes paper https://www.cell.com/cell-systems/fulltext/S2405-4712(19)30073-0 and our github https://github.com/chris-mcginnis-ucsf/DoubletFinder
License: CC-0
Encoding: UTF-8
LazyData: true