diff --git a/CHANGELOG.md b/CHANGELOG.md
index 8e4f4d97bf..470eb43f54 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -45,9 +45,12 @@ and this project adheres to
 - @cosmjs/cosmwasm-stargate: Add constructors `CosmWasmClient.create` and
   `SigningCosmWasmClient.createWithSigner` to construct with a given Tendermint
   client ([#1376]).
+- @cosmjs/cosmwasm-stargate: Add `instantiate2Address` to pre-calculate
+  addresses for Instantiate2 ([#1253]).
 - @cosmjs/stargate: Add `txIndex` to `DeliverTxResponse` and `IndexedTx`
   ([#1361]).
 
+[#1253]: https://github.com/cosmos/cosmjs/pull/1253
 [#1308]: https://github.com/cosmos/cosmjs/pull/1308
 [#1361]: https://github.com/cosmos/cosmjs/issues/1361
 [#1376]: https://github.com/cosmos/cosmjs/pull/1376
diff --git a/packages/cli/examples/instantiate2_addresses.ts b/packages/cli/examples/instantiate2_addresses.ts
new file mode 100644
index 0000000000..566c064052
--- /dev/null
+++ b/packages/cli/examples/instantiate2_addresses.ts
@@ -0,0 +1,62 @@
+import { fromBech32, fromHex, toBech32, toHex, toUtf8 } from "@cosmjs/encoding";
+import { _instantiate2AddressIntermediate } from "@cosmjs/cosmwasm-stargate";
+
+function makeTestingAddress(length: number): string {
+  let data = new Uint8Array(length);
+  data.fill(0x99, 0);
+  data.fill(0xaa, 5);
+  data.fill(0xbb, 10);
+  data.fill(0xcc, 15);
+  data.fill(0xdd, 20);
+  data.fill(0xee, 25);
+  data.fill(0xff, 30);
+  return toBech32("purple", data);
+}
+
+let out: Array<any> = [];
+
+const checksums = [
+  fromHex("13a1fc994cc6d1c81b746ee0c0ff6f90043875e0bf1d9be6b7d779fc978dc2a5"),
+  fromHex("1da6c16de2cbaf7ad8cbb66f0925ba33f5c278cb2491762d04658c1480ea229b"),
+];
+const salts = [
+  toUtf8("a"),
+  fromHex(
+    "AABBCCDDEEFFFFEEDDBBCCDDAA66551155aaaaBBCC787878789900AABBCCDDEEFFFFEEDDBBCCDDAA66551155aaaaBBCC787878789900aabbbbcc221100acadae",
+  ),
+];
+const msgs = [null, JSON.stringify({}), JSON.stringify({ some: 123, structure: { nested: ["ok", true] } })];
+
+for (let checksum of checksums) {
+  for (let creator of [makeTestingAddress(20), makeTestingAddress(32)]) {
+    for (let salt of salts) {
+      for (let msg of msgs) {
+        const { key, addressData, address } = _instantiate2AddressIntermediate(
+          checksum,
+          creator,
+          salt,
+          msg,
+          "purple",
+        );
+        out.push({
+          in: {
+            checksum: toHex(checksum),
+            creator,
+            creatorData: toHex(fromBech32(creator).data),
+            salt: toHex(salt),
+            msg,
+          },
+          intermediate: {
+            key: toHex(key),
+            addressData: toHex(addressData),
+          },
+          out: {
+            address: address,
+          },
+        });
+      }
+    }
+  }
+}
+
+console.log(JSON.stringify(out, undefined, 2));
diff --git a/packages/cli/run_examples.sh b/packages/cli/run_examples.sh
index f4edba233d..c276f1197f 100755
--- a/packages/cli/run_examples.sh
+++ b/packages/cli/run_examples.sh
@@ -10,6 +10,7 @@ if [ -n "${SIMAPP44_ENABLED:-}" ]; then
 fi
 yarn node ./bin/cosmjs-cli --init examples/faucet_addresses.ts --code "process.exit(0)"
 yarn node ./bin/cosmjs-cli --init examples/generate_address.ts --code "process.exit(0)"
+yarn node ./bin/cosmjs-cli --init examples/instantiate2_addresses.ts  --code "process.exit(0)"
 yarn node ./bin/cosmjs-cli --init examples/local_faucet.ts --code "process.exit(0)"
 yarn node ./bin/cosmjs-cli --init examples/mask.ts --code "process.exit(0)"
 yarn node ./bin/cosmjs-cli --init examples/multisig_address.ts --code "process.exit(0)"
diff --git a/packages/cosmwasm-stargate/src/index.ts b/packages/cosmwasm-stargate/src/index.ts
index c41663d936..2db1cb3911 100644
--- a/packages/cosmwasm-stargate/src/index.ts
+++ b/packages/cosmwasm-stargate/src/index.ts
@@ -1,5 +1,6 @@
 export { Code, CodeDetails, Contract, ContractCodeHistoryEntry, CosmWasmClient } from "./cosmwasmclient";
 export { fromBinary, toBinary } from "./encoding";
+export { _instantiate2AddressIntermediate, instantiate2Address } from "./instantiate2";
 export {
   cosmWasmTypes,
   createWasmAminoConverters,
diff --git a/packages/cosmwasm-stargate/src/instantiate2.spec.ts b/packages/cosmwasm-stargate/src/instantiate2.spec.ts
new file mode 100644
index 0000000000..571346e521
--- /dev/null
+++ b/packages/cosmwasm-stargate/src/instantiate2.spec.ts
@@ -0,0 +1,53 @@
+import { fromHex } from "@cosmjs/encoding";
+
+import { instantiate2Address } from "./instantiate2";
+
+describe("instantiate2", () => {
+  describe("instantiate2Address", () => {
+    it("works", () => {
+      // Some entries from https://gist.github.com/webmaster128/e4d401d414bd0e7e6f70482f11877fbe
+      {
+        const checksum = fromHex("13a1fc994cc6d1c81b746ee0c0ff6f90043875e0bf1d9be6b7d779fc978dc2a5");
+        const creator = "purple1nxvenxve42424242hwamhwamenxvenxvhxf2py";
+        const salt = fromHex("61");
+        expect(instantiate2Address(checksum, creator, salt, "purple")).toEqual(
+          "purple1t6r960j945lfv8mhl4mage2rg97w63xeynwrupum2s2l7em4lprs9ce5hk",
+        );
+      }
+      {
+        const checksum = fromHex("13a1fc994cc6d1c81b746ee0c0ff6f90043875e0bf1d9be6b7d779fc978dc2a5");
+        const creator = "purple1nxvenxve42424242hwamhwamenxvenxvhxf2py";
+        const salt = fromHex(
+          "aabbccddeeffffeeddbbccddaa66551155aaaabbcc787878789900aabbccddeeffffeeddbbccddaa66551155aaaabbcc787878789900aabbbbcc221100acadae",
+        );
+        expect(instantiate2Address(checksum, creator, salt, "purple")).toEqual(
+          "purple1jwzvvfyvpwchrccxl476pxf7c83qawsqv3f2820q0zyrav6eg4jqdcq7gc",
+        );
+      }
+      {
+        const checksum = fromHex("13a1fc994cc6d1c81b746ee0c0ff6f90043875e0bf1d9be6b7d779fc978dc2a5");
+        const creator = "purple1nxvenxve42424242hwamhwamenxvenxvmhwamhwaamhwamhwlllsatsy6m";
+        const salt = fromHex("61");
+        expect(instantiate2Address(checksum, creator, salt, "purple")).toEqual(
+          "purple1juj7jn6j3k9h35euyhealntquc2zmzlxp2ek76jmtypkl4g4vrdsfwmwxk",
+        );
+      }
+      {
+        const checksum = fromHex("13a1fc994cc6d1c81b746ee0c0ff6f90043875e0bf1d9be6b7d779fc978dc2a5");
+        const creator = "purple1nxvenxve42424242hwamhwamenxvenxvmhwamhwaamhwamhwlllsatsy6m";
+        const salt = fromHex("61");
+        expect(instantiate2Address(checksum, creator, salt, "purple")).toEqual(
+          "purple1juj7jn6j3k9h35euyhealntquc2zmzlxp2ek76jmtypkl4g4vrdsfwmwxk",
+        );
+      }
+      {
+        const checksum = fromHex("1da6c16de2cbaf7ad8cbb66f0925ba33f5c278cb2491762d04658c1480ea229b");
+        const creator = "purple1nxvenxve42424242hwamhwamenxvenxvhxf2py";
+        const salt = fromHex("61");
+        expect(instantiate2Address(checksum, creator, salt, "purple")).toEqual(
+          "purple1h9wyvusc6sy2p7fsgmez0dhvullpsyel7vq38k6d9fa7ehlv59qsvnyh36",
+        );
+      }
+    });
+  });
+});
diff --git a/packages/cosmwasm-stargate/src/instantiate2.ts b/packages/cosmwasm-stargate/src/instantiate2.ts
new file mode 100644
index 0000000000..edc7f251eb
--- /dev/null
+++ b/packages/cosmwasm-stargate/src/instantiate2.ts
@@ -0,0 +1,69 @@
+import { Sha256, sha256 } from "@cosmjs/crypto";
+import { fromBech32, toAscii, toBech32, toUtf8 } from "@cosmjs/encoding";
+import { Uint64 } from "@cosmjs/math";
+import { assert } from "@cosmjs/utils";
+
+/**
+ * The "Basic Address" Hash from
+ * https://github.com/cosmos/cosmos-sdk/blob/v0.45.8/docs/architecture/adr-028-public-key-addresses.md
+ */
+function hash(type: string, key: Uint8Array): Uint8Array {
+  return new Sha256(sha256(toAscii(type))).update(key).digest();
+}
+
+/**
+ * Takes an integer [0, 2**64-1] and returns a one-byte encoding of it.
+ */
+function toUint64(int: number): Uint8Array {
+  return Uint64.fromNumber(int).toBytesBigEndian();
+}
+
+/**
+ * Private function to export test vector data for https://github.com/cosmos/cosmjs/pull/1253.
+ * Do not use in production code.
+ */
+// eslint-disable-next-line @typescript-eslint/naming-convention
+export function _instantiate2AddressIntermediate(
+  checksum: Uint8Array,
+  creator: string,
+  salt: Uint8Array,
+  msg: string | null,
+  prefix: string,
+): { key: Uint8Array; addressData: Uint8Array; address: string } {
+  assert(checksum.length === 32);
+  const creatorData = fromBech32(creator).data;
+
+  const msgData = typeof msg === "string" ? toUtf8(msg) : new Uint8Array();
+
+  // Validate inputs
+  if (salt.length < 1 || salt.length > 64) throw new Error("Salt must be between 1 and 64 bytes");
+
+  const key = new Uint8Array([
+    ...toAscii("wasm"),
+    0x00,
+    ...toUint64(checksum.length),
+    ...checksum,
+    ...toUint64(creatorData.length),
+    ...creatorData,
+    ...toUint64(salt.length),
+    ...salt,
+    ...toUint64(msgData.length),
+    ...msgData,
+  ]);
+  const addressData = hash("module", key);
+  const address = toBech32(prefix, addressData);
+  return { key, addressData, address };
+}
+
+/**
+ * Predictable address generation for the MsgInstantiateContract2
+ * introduced with wasmd 0.29.
+ */
+export function instantiate2Address(
+  checksum: Uint8Array,
+  creator: string,
+  salt: Uint8Array,
+  prefix: string,
+): string {
+  return _instantiate2AddressIntermediate(checksum, creator, salt, null, prefix).address;
+}