metadata.yaml

about:
- identifier: UBERON:0002421
  name: hippocampus
  schemaKey: Anatomy
access:
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  status: dandi:OpenAccess
assetsSummary:
  approach:
  - name: behavioral approach
    schemaKey: ApproachType
  - name: electrophysiological approach
    schemaKey: ApproachType
  - name: optogenetic approach
    schemaKey: ApproachType
  dataStandard:
  - identifier: RRID:SCR_015242
    name: Neurodata Without Borders (NWB)
    schemaKey: StandardsType
  measurementTechnique:
  - name: spike sorting technique
    schemaKey: MeasurementTechniqueType
  - name: behavioral technique
    schemaKey: MeasurementTechniqueType
  - name: signal filtering technique
    schemaKey: MeasurementTechniqueType
  - name: analytical technique
    schemaKey: MeasurementTechniqueType
  - name: surgical technique
    schemaKey: MeasurementTechniqueType
  - name: multi electrode extracellular electrophysiology recording technique
    schemaKey: MeasurementTechniqueType
  numberOfBytes: 904756915175
  numberOfFiles: 138
  numberOfSubjects: 4
  schemaKey: AssetsSummary
  species:
  - identifier: http://purl.obolibrary.org/obo/NCBITaxon_10090
    name: Mus musculus - House mouse
    schemaKey: SpeciesType
  variableMeasured:
  - LFP
  - Units
  - SpatialSeries
  - ElectrodeGroup
  - ElectricalSeries
  - Position
  - ProcessingModule
  - OptogeneticSeries
citation: "Valero, Manuel;  Zutshi, Ipshita; Yoon, Euisik; Buzs\xE1ki, Gy\xF6rgy (2024)
  Probing subthreshold dynamics of hippocampal neurons by pulsed optogenetics (Version
  draft) [Data set]. DANDI archive. https://dandiarchive.org/dandiset/000568/draft"
contributor:
- affiliation: []
  email: valegarman@gmail.com
  identifier: 0000-0001-7860-577X
  includeInCitation: true
  name: Valero, Manuel
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  - dcite:Software
  - dcite:Validation
  - dcite:Visualization
  schemaKey: Person
  url: https://valeroneuroscience.com/
- affiliation: []
  identifier: 0000-0001-8180-0816
  includeInCitation: true
  name: ' Zutshi, Ipshita'
  roleName:
  - dcite:Methodology
  - dcite:Author
  schemaKey: Person
- affiliation: []
  identifier: 0000-0002-2127-1200
  includeInCitation: true
  name: Yoon, Euisik
  roleName:
  - dcite:Author
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  - dcite:Supervision
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  schemaKey: Person
- affiliation: []
  email: gyorgy.buzsaki@nyumc.org
  identifier: 0000-0002-3100-4800
  includeInCitation: true
  name: "Buzs\xE1ki, Gy\xF6rgy"
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  - dcite:Methodology
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  - dcite:Researcher
  schemaKey: Person
- awardNumber: ' LT0000717/2018, NIH MH107396, NS 090583 NSF PIRE, 1545858, U19 NS107616,
    U19 NS104590, LT0000717/2018'
  contactPoint: []
  identifier: https://ror.org/02ebx7v45
  includeInCitation: false
  name: International Human Frontier Science Program Organization
  roleName:
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  url: http://www.hfsp.org/
- awardNumber: MH107396, U19NS107616
  contactPoint: []
  identifier: https://ror.org/01cwqze88
  includeInCitation: false
  name: National Institutes of Health
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  url: http://www.nih.gov/
- awardNumber: NS107616
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  identifier: https://ror.org/04xeg9z08
  includeInCitation: false
  name: National Institute of Mental Health
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  url: https://www.nimh.nih.gov/
- awardNumber: EMBO ALTF 1161-2017
  contactPoint: []
  identifier: https://ror.org/04wfr2810
  includeInCitation: false
  name: European Molecular Biology Organization
  roleName:
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  schemaKey: Organization
  url: https://www.embo.org/
- awardNumber: NeuroNex MINT grant 1707316
  contactPoint: []
  identifier: https://ror.org/021nxhr62
  includeInCitation: false
  name: National Science Foundation
  roleName:
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  schemaKey: Organization
  url: http://www.nsf.gov/
- awardNumber: NIH MH107396,  NS 090583 NSF PIRE, 1545858, U19 NS107616
  contactPoint: []
  identifier: https://ror.org/033hnyq61
  includeInCitation: false
  name: Leon Levy Foundation
  roleName:
  - dcite:Funder
  schemaKey: Organization
  url: http://leonlevyfoundation.org/
- affiliation: []
  email: h.mayorquin@gmail.com
  includeInCitation: false
  name: Mayorquin, Heberto
  roleName:
  - dcite:DataCurator
  schemaKey: Person
dateCreated: '2023-06-28T15:39:24.241528+00:00'
description: "Understanding how excitatory (E) and inhibitory (I) inputs are integrated
  by neurons requires monitoring their subthreshold behavior. We probed the subthreshold
  dynamics using optogenetic depolarizing pulses in hippocampal neuronal assemblies
  in freely moving mice. Excitability decreased during sharp- wave ripples coupled
  with increased I. In contrast to this \u201Cnegative gain,\u201D optogenetic probing
  showed increased within-field excitability in place cells by weakening I and unmasked
  stable place fields in initially non\u2013place cells. Neuronal assemblies active
  during sharp-wave ripples in the home cage predicted spatial overlap and sequences
  of place fields of both place cells and unmasked preexisting place fields of non\u2013place
  cells during track running. Thus, indirect probing of subthreshold dynamics in neuronal
  populations permits the disclosing of preexisting assemblies and modes of neuronal
  operations."
ethicsApproval: []
id: DANDI:000568/draft
identifier: DANDI:000568
keywords: []
license:
- spdx:CC-BY-4.0
manifestLocation:
- https://api.dandiarchive.org/api/dandisets/000568/versions/draft/assets/
name: Probing subthreshold dynamics of hippocampal neurons by pulsed optogenetics
protocol: []
relatedResource:
- identifier: https://doi.org/10.1126/science.abm1891
  name: ' Probing subthreshold dynamics of hippocampal neurons by pulsed optogenetics'
  relation: dcite:IsDescribedBy
  repository: Science
  resourceType: dcite:JournalArticle
  schemaKey: Resource
  url: https://www.science.org/doi/10.1126/science.abm1891
repository: https://dandiarchive.org
schemaKey: Dandiset
schemaVersion: 0.6.4
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url: https://dandiarchive.org/dandiset/000568/draft
version: draft
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