metadata.yaml

about:
- name: Medial Temporal Lobe
  schemaKey: GenericType
- name: Medial Frontal Cortex
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  status: dandi:OpenAccess
assetsSummary:
  approach:
  - name: electrophysiological approach
    schemaKey: ApproachType
  dataStandard:
  - identifier: RRID:SCR_015242
    name: Neurodata Without Borders (NWB)
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  measurementTechnique:
  - name: multi electrode extracellular electrophysiology recording technique
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  - name: surgical technique
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  - name: spike sorting technique
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  numberOfFiles: 44
  numberOfSubjects: 36
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  species:
  - identifier: http://purl.obolibrary.org/obo/NCBITaxon_9606
    name: Homo sapiens - Human
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citation: "Daume, Jonathan; Kaminski, Jan; Schjetnan, Andrea G. P. ; Salimpour, Yousef;
  Khan, Umais; Kyzar, Michael; Reed, Chrystal M.; Anderson, William S.; Valiante,
  Taufik A.; Mamelak, Adam N.; Rutishauser, Ueli (2024) Data for: Control of working
  memory by phase\u2013amplitude coupling of human hippocampal neurons (Version 0.240524.1758)
  [Data set]. DANDI archive. https://doi.org/10.48324/dandi.000673/0.240524.1758"
contributor:
- affiliation:
  - name: Department of Neurosurgery, Cedars-Sinai Medical Center
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  - name: Department of Neurology, Cedars-Sinai Medical Center
    schemaKey: Affiliation
  - name: Center for Neural Science and Medicine, Department of Biomedical Sciences,
      Cedars-Sinai Medical Center
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  email: Jonathan.Daume@cshs.org
  identifier: 0000-0002-6516-7288
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  name: Daume, Jonathan
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- affiliation:
  - name: Department of Neurosurgery, Cedars-Sinai Medical Center
    schemaKey: Affiliation
  - name: 'Center of Excellence for Neural Plasticity and Brain Disorders: BRAINCITY,
      Nencki Institute of Experi-15 mental Biology, Polish Academy of Sciences'
    schemaKey: Affiliation
  identifier: 0000-0002-8663-7314
  includeInCitation: true
  name: Kaminski, Jan
  roleName:
  - dcite:Author
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  schemaKey: Person
- affiliation:
  - name: Krembil Research Institute and Division of Neurosurgery, University Health
      Network (UHN), University of Toronto
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  identifier: 0000-0002-4319-7689
  includeInCitation: true
  name: 'Schjetnan, Andrea G. P. '
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- affiliation:
  - name: Department of Neurosurgery, Johns Hopkins School of Medicine
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  identifier: 0000-0002-7546-004X
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  name: Salimpour, Yousef
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- affiliation:
  - name: Department of Neurosurgery, Cedars-Sinai Medical Center
    schemaKey: Affiliation
  identifier: 0009-0005-5328-3977
  includeInCitation: true
  name: Khan, Umais
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  - dcite:Author
  - dcite:FormalAnalysis
  schemaKey: Person
- affiliation:
  - name: Department of Neurosurgery, Cedars-Sinai Medical Center
    schemaKey: Affiliation
  email: Michael.Kyzar@cshs.org
  identifier: 0009-0004-4392-9933
  includeInCitation: true
  name: Kyzar, Michael
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  - dcite:Author
  - dcite:DataCurator
  - dcite:DataManager
  - dcite:Software
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  schemaKey: Person
- affiliation:
  - name: Department of Neurology, Cedars-Sinai Medical Center
    schemaKey: Affiliation
  identifier: 0000-0002-7157-3645
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  name: Reed, Chrystal M.
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  - dcite:Author
  - dcite:Methodology
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- affiliation:
  - name: Department of Neurosurgery, Johns Hopkins School of Medicine
    schemaKey: Affiliation
  identifier: 0000-0003-0958-050X
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  name: Anderson, William S.
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- affiliation:
  - name: Krembil Research Institute and Division of Neurosurgery, University Health
      Network (UHN), University of Toronto
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  name: Valiante, Taufik A.
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- affiliation:
  - name: Department of Neurosurgery, Cedars-Sinai Medical Center
    schemaKey: Affiliation
  identifier: 0000-0002-4245-6431
  includeInCitation: true
  name: Mamelak, Adam N.
  roleName:
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  - dcite:Methodology
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- affiliation:
  - name: Department of Neurosurgery, Cedars-Sinai Medical Center
    schemaKey: Affiliation
  - name: Department of Neurology, Cedars-Sinai Medical Center
    schemaKey: Affiliation
  - name: Center for Neural Science and Medicine, Department of Biomedical Sciences,
      Cedars-Sinai Medical Center
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  - name: Division of Biology and Biological Engineering, California Institute of
      Technology
    schemaKey: Affiliation
  identifier: 0000-0002-9207-7069
  includeInCitation: true
  name: Rutishauser, Ueli
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  schemaKey: Person
- awardNumber: 5 U01 NS 117839-04
  contactPoint: []
  identifier: https://ror.org/01cwqze88
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  name: National Institutes of Health (NIH)
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  name: National Institutes of Health (NIH)
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- awardNumber: BCS-2219800
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  name: National Science Foundation (NSF)
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dateCreated: '2023-09-26T20:41:29.787964+00:00'
datePublished: '2024-05-24T17:58:37.705990+00:00'
description: "Retaining information in working memory is a demanding process that
  relies on cognitive control to protect memoranda-specific persistent activity from
  interference. However, how cognitive control regulates working memory storage is
  unclear. Here we show that interactions of frontal control and hippocampal persistent
  activity are coordinated by theta\u2013gamma phase\u2013amplitude coupling (TG-PAC).
  We recorded single neurons in the human medial temporal and frontal lobe while patients
  maintained multiple items in their working memory. In the hippocampus, TG-PAC was
  indicative of working memory load and quality. We identified cells that selectively
  spiked during nonlinear interactions of theta phase and gamma amplitude. The spike
  timing of these PAC neurons was coordinated with frontal theta activity when cognitive
  control demand was high. By introducing noise correlations with persistently active
  neurons in the hippocampus, PAC neurons shaped the geometry of the population code.
  This led to higher-fidelity representations of working memory content that were
  associated with improved behaviour. Our results support a multicomponent architecture
  of working memory, with frontal control managing maintenance of working memory content
  in storage-related areas. Within this framework, hippocampal TG-PAC integrates cognitive
  control and working memory storage across brain areas, thereby suggesting a potential
  mechanism for top-down control over sensory-driven processes.\n\nSample code that
  illustrates how to replicate key figures/analysis in Daume et. al. can be found
  here: https://github.com/rutishauserlab/SBCAT-release-NWB\n\nNote: sub-35_ses-1_ecephys+image.nwb
  is missing mean/std waveform data, but these data can be derived from the raw spike
  waveforms included in the file."
doi: 10.48324/dandi.000673/0.240524.1758
ethicsApproval: []
id: DANDI:000673/0.240524.1758
identifier: DANDI:000673
keywords:
- cognitive neuroscience
- data standardization
- working memory
- neurophysiology
- neurosurgery
- NWB
- open source
- single-neurons
- phase-amplitude coupling
license:
- spdx:CC-BY-4.0
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name: "Data for: Control of working memory by phase\u2013amplitude coupling of human
  hippocampal neurons"
protocol: []
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  url: https://www.nature.com/articles/s41586-024-07309-z
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