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  name: Brain
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  name: Walking Behavior
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  name: locomotory behavior
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  name: locomotion
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  name: spontaneous movement behavior
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    name: Neurodata Without Borders (NWB)
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  species:
  - identifier: http://purl.obolibrary.org/obo/NCBITaxon_7227
    name: Drosophila melanogaster - Fruit fly
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citation: Brezovec, Luke; Berger, Andrew; Druckmann, Shaul ; Clandinin, Thomas (2024)
  Mapping the Neural Dynamics of Locomotion across the Drosophila Brain (Version 0.240106.0043)
  [Data set]. DANDI archive. https://doi.org/10.48324/dandi.000727/0.240106.0043
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  name: Brezovec, Luke
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  name: Berger, Andrew
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  name: 'Druckmann, Shaul '
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  email: trc@stanford.edu
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  name: Clandinin, Thomas
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  url: http://clandininlab.stanford.edu/
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  name: National Institutes of Health
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  name: Simons Foundation
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  name: Mayorquin, Heberto
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  name: Trapani, Alessandra
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dateCreated: '2023-12-10T10:22:46.518636+00:00'
datePublished: '2024-01-06T00:43:26.650046+00:00'
description: Walking is a fundamental mode of locomotion, yet its neural correlates
  are unknown at brain-wide scale in any animal. We use volumetric two-photon imaging
  to map neural activity associated with walking across the entire brain of Drosophila.
  We detect locomotor signals in approximately 40% of the brain, identify a global
  signal associated with the transition from rest to walking, and define clustered
  neural signals selectively associated with changes in forward or angular velocity.
  These networks span functionally diverse brain regions, and include regions that
  have not been previously linked to locomotion. We also identify time-varying trajectories
  of neural activity that anticipate future movements, and that represent sequential
  engagement of clusters of neurons with different behavioral selectivity. These motor
  maps suggest a dynamical systems framework for constructing walking maneuvers reminiscent
  of models of forelimb reaching in primates and set a foundation for understanding
  how local circuits interact across large-scale networks.
doi: 10.48324/dandi.000727/0.240106.0043
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name: Mapping the Neural Dynamics of Locomotion across the Drosophila Brain
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  name: Mapping the Neural Dynamics of Locomotion across the Drosophila Brain
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  repository: bioRxiv
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  url: https://doi.org/10.1101/2022.03.20.485047
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