diff --git a/ext/node/polyfills/testing.ts b/ext/node/polyfills/testing.ts
index b04456ce8d086e..b6733f118cd766 100644
--- a/ext/node/polyfills/testing.ts
+++ b/ext/node/polyfills/testing.ts
@@ -61,6 +61,9 @@ class NodeTestContext {
         await prepared.fn(newNodeTextContext);
       },
       ignore: prepared.options.todo || prepared.options.skip,
+      sanitizeExit: false,
+      sanitizeOps: false,
+      sanitizeResources: false,
     }).then(() => undefined);
   }
 
@@ -131,6 +134,9 @@ function prepareDenoTest(name, options, fn, overrides) {
     fn: wrapTestFn(prepared.fn, resolve),
     only: prepared.options.only,
     ignore: prepared.options.todo || prepared.options.skip,
+    sanitizeExit: false,
+    sanitizeOps: false,
+    sanitizeResources: false,
   };
   Deno.test(denoTestOptions);
   return promise;
diff --git a/tests/integration/node_compat_tests.rs b/tests/integration/node_compat_tests.rs
index 767f23460b4fb8..26f691636af2e3 100644
--- a/tests/integration/node_compat_tests.rs
+++ b/tests/integration/node_compat_tests.rs
@@ -11,3 +11,11 @@ itest!(node_test_module {
   exit_code: 1,
   http_server: true,
 });
+
+itest!(node_test_module_no_sanitizers {
+  args: "test -A --no-check node/test_no_sanitizers/test.js",
+  output: "node/test_no_sanitizers/test.out",
+  envs: env_vars_for_npm_tests(),
+  exit_code: 123,
+  http_server: true,
+});
diff --git a/tests/testdata/node/test_no_sanitizers/test.js b/tests/testdata/node/test_no_sanitizers/test.js
new file mode 100644
index 00000000000000..d2ca8a6c76363b
--- /dev/null
+++ b/tests/testdata/node/test_no_sanitizers/test.js
@@ -0,0 +1,28 @@
+import test from "node:test";
+
+test("should not complain about resource and op sanitizers", async (t) => {
+  // resource
+  const _file1 = Deno.open("welcome.ts");
+
+  await t.test("nested test", () => {
+    // resource
+    const _file2 = Deno.open("cat.ts");
+
+    // op
+    crypto.subtle.digest(
+      "SHA-256",
+      new TextEncoder().encode("a".repeat(1_000_000)),
+    );
+  });
+
+  // op
+  crypto.subtle.digest(
+    "SHA-256",
+    new TextEncoder().encode("a".repeat(1_000_000)),
+  );
+});
+
+test("should allow exit", () => {
+  // no exit sanitizers
+  Deno.exit(123);
+});
diff --git a/tests/testdata/node/test_no_sanitizers/test.out b/tests/testdata/node/test_no_sanitizers/test.out
new file mode 100644
index 00000000000000..f52bed3abecd67
--- /dev/null
+++ b/tests/testdata/node/test_no_sanitizers/test.out
@@ -0,0 +1,5 @@
+running 2 tests from ./node/test_no_sanitizers/test.js
+should not complain about resource and op sanitizers ...
+  nested test ... ok ([WILDCARD])
+should not complain about resource and op sanitizers ... ok ([WILDCARD])
+should allow exit ...
\ No newline at end of file