diff --git a/src/libraries/System.Net.Quic/src/System/Net/Quic/Implementations/MsQuic/Internal/MsQuicApi.cs b/src/libraries/System.Net.Quic/src/System/Net/Quic/Implementations/MsQuic/Internal/MsQuicApi.cs
index d483c76a0ac36..b52b48282e218 100644
--- a/src/libraries/System.Net.Quic/src/System/Net/Quic/Implementations/MsQuic/Internal/MsQuicApi.cs
+++ b/src/libraries/System.Net.Quic/src/System/Net/Quic/Implementations/MsQuic/Internal/MsQuicApi.cs
@@ -18,23 +18,8 @@ internal class MsQuicApi : IDisposable
 
         private readonly IntPtr _registrationContext;
 
-        private unsafe MsQuicApi()
+        private unsafe MsQuicApi(MsQuicNativeMethods.NativeApi* registration)
         {
-            MsQuicNativeMethods.NativeApi* registration;
-
-            try
-            {
-                uint status = Interop.MsQuic.MsQuicOpen(out registration);
-                if (!MsQuicStatusHelper.SuccessfulStatusCode(status))
-                {
-                    throw new NotSupportedException(SR.net_quic_notsupported);
-                }
-            }
-            catch (DllNotFoundException)
-            {
-                throw new NotSupportedException(SR.net_quic_notsupported);
-            }
-
             MsQuicNativeMethods.NativeApi nativeRegistration = *registration;
 
             RegistrationOpenDelegate =
@@ -138,7 +123,7 @@ private unsafe MsQuicApi()
 
         internal static bool IsQuicSupported { get; }
 
-        static MsQuicApi()
+        static unsafe MsQuicApi()
         {
             // MsQuicOpen will succeed even if the platform will not support it. It will then fail with unspecified
             // platform-specific errors in subsequent callbacks. For now, check for the minimum build we've tested it on.
@@ -150,14 +135,30 @@ static MsQuicApi()
 
             // TODO: try to initialize TLS 1.3 in SslStream.
 
-            try
-            {
-                Api = new MsQuicApi();
-                IsQuicSupported = true;
-            }
-            catch (NotSupportedException)
+            // TODO: Consider updating all of these delegates to instead use function pointers.
+
+            if (NativeLibrary.TryLoad(Interop.Libraries.MsQuic, out IntPtr msQuicHandle))
             {
-                IsQuicSupported = false;
+                try
+                {
+                    if (NativeLibrary.TryGetExport(msQuicHandle, "MsQuicOpen", out IntPtr msQuicOpenAddress))
+                    {
+                        MsQuicNativeMethods.MsQuicOpenDelegate msQuicOpen = Marshal.GetDelegateForFunctionPointer<MsQuicNativeMethods.MsQuicOpenDelegate>(msQuicOpenAddress);
+                        uint status = msQuicOpen(out MsQuicNativeMethods.NativeApi* registration);
+                        if (MsQuicStatusHelper.SuccessfulStatusCode(status))
+                        {
+                            IsQuicSupported = true;
+                            Api = new MsQuicApi(registration);
+                        }
+                    }
+                }
+                finally
+                {
+                    if (!IsQuicSupported)
+                    {
+                        NativeLibrary.Free(msQuicHandle);
+                    }
+                }
             }
         }
 
diff --git a/src/libraries/System.Net.Quic/src/System/Net/Quic/Interop/Interop.MsQuic.cs b/src/libraries/System.Net.Quic/src/System/Net/Quic/Interop/Interop.MsQuic.cs
deleted file mode 100644
index b873b789f1d22..0000000000000
--- a/src/libraries/System.Net.Quic/src/System/Net/Quic/Interop/Interop.MsQuic.cs
+++ /dev/null
@@ -1,15 +0,0 @@
-// Licensed to the .NET Foundation under one or more agreements.
-// The .NET Foundation licenses this file to you under the MIT license.
-
-using System;
-using System.Net.Quic.Implementations.MsQuic.Internal;
-using System.Runtime.InteropServices;
-
-internal static partial class Interop
-{
-    internal static class MsQuic
-    {
-        [DllImport(Libraries.MsQuic, CallingConvention = CallingConvention.Cdecl)]
-        internal static unsafe extern uint MsQuicOpen(out MsQuicNativeMethods.NativeApi* registration);
-    }
-}
diff --git a/src/libraries/System.Net.Quic/src/System/Net/Quic/Interop/MsQuicNativeMethods.cs b/src/libraries/System.Net.Quic/src/System/Net/Quic/Interop/MsQuicNativeMethods.cs
index c8ff6d6a8422c..3027c402bb0ee 100644
--- a/src/libraries/System.Net.Quic/src/System/Net/Quic/Interop/MsQuicNativeMethods.cs
+++ b/src/libraries/System.Net.Quic/src/System/Net/Quic/Interop/MsQuicNativeMethods.cs
@@ -54,6 +54,10 @@ internal struct NativeApi
             internal IntPtr DatagramSend;
         }
 
+        [UnmanagedFunctionPointer(CallingConvention.Cdecl)]
+        internal delegate uint MsQuicOpenDelegate(
+            out NativeApi* registration);
+
         [UnmanagedFunctionPointer(CallingConvention.Cdecl)]
         internal delegate uint SetContextDelegate(
             IntPtr handle,