diff --git a/src/tests/issues.targets b/src/tests/issues.targets
index 265fafc5d79ed..b09993f933894 100644
--- a/src/tests/issues.targets
+++ b/src/tests/issues.targets
@@ -72,6 +72,9 @@
         <ExcludeList Include="$(XunitTestBinBase)/JIT/Regression/JitBlue/Runtime_82535/Runtime_82535/*">
           <Issue>https://github.com/dotnet/runtime/issues/89585</Issue>
         </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/readytorun/GenericCycleDetection/Depth3Test/*">
+          <Issue>https://github.com/dotnet/runtime/issues/88586</Issue>
+        </ExcludeList>
     </ItemGroup>
 
     <!-- All Unix targets on all runtimes -->