diff --git a/src/libraries/System.Net.Http/tests/FunctionalTests/SocketsHttpHandlerTest.cs b/src/libraries/System.Net.Http/tests/FunctionalTests/SocketsHttpHandlerTest.cs
index d8b7ec4e712cd..b326c8bbb0214 100644
--- a/src/libraries/System.Net.Http/tests/FunctionalTests/SocketsHttpHandlerTest.cs
+++ b/src/libraries/System.Net.Http/tests/FunctionalTests/SocketsHttpHandlerTest.cs
@@ -2119,6 +2119,7 @@ public async Task Http2_MultipleConnectionsEnabled_ConnectionLimitNotReached_Con
         }
 
         [ConditionalFact(nameof(SupportsAlpn))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/45204")]
         public async Task Http2_MultipleConnectionsEnabled_InfiniteRequestsCompletelyBlockOneConnection_RemaningRequestsAreHandledByNewConnection()
         {
             const int MaxConcurrentStreams = 2;