diff --git a/src/libraries/Microsoft.CSharp/src/ILLink/ILLink.Descriptors.Windows.xml b/src/libraries/Microsoft.CSharp/src/ILLink/ILLink.Descriptors.Windows.xml
index 4bf5dd43f040f..2bb2ba66d878c 100644
--- a/src/libraries/Microsoft.CSharp/src/ILLink/ILLink.Descriptors.Windows.xml
+++ b/src/libraries/Microsoft.CSharp/src/ILLink/ILLink.Descriptors.Windows.xml
@@ -1,5 +1,5 @@
 <linker>
-  <assembly fullname="Microsoft.CSharp">
+  <assembly fullname="Microsoft.CSharp" feature="System.Runtime.InteropServices.BuiltInComInterop.IsSupported" featurevalue="true" featuredefault="true">
     <!-- Required for COM event dispatch -->
     <type fullname="System.Runtime.InteropServices.ComEventsSink"/>
   </assembly>
diff --git a/src/libraries/System.Private.CoreLib/src/ILLink/ILLink.LinkAttributes.Shared.xml b/src/libraries/System.Private.CoreLib/src/ILLink/ILLink.LinkAttributes.Shared.xml
index 5cd3d582f6f8f..3349f853d44f5 100644
--- a/src/libraries/System.Private.CoreLib/src/ILLink/ILLink.LinkAttributes.Shared.xml
+++ b/src/libraries/System.Private.CoreLib/src/ILLink/ILLink.LinkAttributes.Shared.xml
@@ -88,6 +88,34 @@
     </type>
   </assembly>
 
+  <!-- The following attributes are only necessary when COM is supported -->
+  <assembly fullname="System.Private.CoreLib" feature="System.Runtime.InteropServices.BuiltInComInterop.IsSupported" featurevalue="false">
+    <type fullname="System.Runtime.InteropServices.ClassInterfaceAttribute">
+      <attribute internal="RemoveAttributeInstances" />
+    </type>
+    <type fullname="System.Runtime.InteropServices.ComDefaultInterfaceAttribute">
+      <attribute internal="RemoveAttributeInstances" />
+    </type>
+    <type fullname="System.Runtime.InteropServices.ComEventInterfaceAttribute">
+      <attribute internal="RemoveAttributeInstances" />
+    </type>
+    <type fullname="System.Runtime.InteropServices.ComSourceInterfacesAttribute">
+      <attribute internal="RemoveAttributeInstances" />
+    </type>
+    <type fullname="System.Runtime.InteropServices.ComVisibleAttribute">
+      <attribute internal="RemoveAttributeInstances" />
+    </type>
+    <type fullname="System.Runtime.InteropServices.DispIdAttribute">
+      <attribute internal="RemoveAttributeInstances" />
+    </type>
+    <type fullname="System.Runtime.InteropServices.InterfaceTypeAttribute">
+      <attribute internal="RemoveAttributeInstances" />
+    </type>
+    <type fullname="System.Runtime.InteropServices.ProgIdAttribute">
+      <attribute internal="RemoveAttributeInstances" />
+    </type>
+  </assembly>
+
   <!--
     Attributes listed below here should be behind the 'System.AggressiveAttributeTrimming' feature switch, which
     is only enabled by default on app models that need as much size savings as possible.
diff --git a/src/libraries/System.Private.CoreLib/src/System/DefaultBinder.cs b/src/libraries/System.Private.CoreLib/src/System/DefaultBinder.cs
index 32a6f6db2ff3f..47028f9b8d408 100644
--- a/src/libraries/System.Private.CoreLib/src/System/DefaultBinder.cs
+++ b/src/libraries/System.Private.CoreLib/src/System/DefaultBinder.cs
@@ -3,6 +3,7 @@
 
 using System.Reflection;
 using System.Diagnostics;
+using System.Runtime.InteropServices;
 using CultureInfo = System.Globalization.CultureInfo;
 
 namespace System
@@ -227,7 +228,7 @@ public sealed override MethodBase BindToMethod(
 
                         if (!pCls.IsAssignableFrom(argTypes[paramOrder[i][j]]))
                         {
-                            if (argTypes[paramOrder[i][j]].IsCOMObject)
+                            if (Marshal.IsBuiltInComSupported && argTypes[paramOrder[i][j]].IsCOMObject)
                             {
                                 if (pCls.IsInstanceOfType(args[paramOrder[i][j]]))
                                     continue;
@@ -255,7 +256,7 @@ public sealed override MethodBase BindToMethod(
 
                             if (!paramArrayType.IsAssignableFrom(argTypes[j]))
                             {
-                                if (argTypes[j].IsCOMObject)
+                                if (Marshal.IsBuiltInComSupported && argTypes[j].IsCOMObject)
                                 {
                                     if (paramArrayType.IsInstanceOfType(args[j]))
                                         continue;
diff --git a/src/libraries/System.Private.CoreLib/src/System/Runtime/InteropServices/Marshal.NoCom.cs b/src/libraries/System.Private.CoreLib/src/System/Runtime/InteropServices/Marshal.NoCom.cs
index 61073d1d6c2a2..9229f26f57a48 100644
--- a/src/libraries/System.Private.CoreLib/src/System/Runtime/InteropServices/Marshal.NoCom.cs
+++ b/src/libraries/System.Private.CoreLib/src/System/Runtime/InteropServices/Marshal.NoCom.cs
@@ -10,6 +10,8 @@ namespace System.Runtime.InteropServices
 {
     public static partial class Marshal
     {
+        internal static bool IsBuiltInComSupported => false;
+
         public static int GetHRForException(Exception? e)
         {
             return e?.HResult ?? 0;