diff --git a/src/libraries/System.Net.Http/tests/FunctionalTests/HttpClientHandlerTest.Http2.cs b/src/libraries/System.Net.Http/tests/FunctionalTests/HttpClientHandlerTest.Http2.cs
index c9c5db60d0f00..1aadb515353a2 100644
--- a/src/libraries/System.Net.Http/tests/FunctionalTests/HttpClientHandlerTest.Http2.cs
+++ b/src/libraries/System.Net.Http/tests/FunctionalTests/HttpClientHandlerTest.Http2.cs
@@ -243,6 +243,7 @@ public async Task Http2_ServerSendsValidSettingsValues_Success()
             }
         }
 
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/1581")]
         [ConditionalTheory(nameof(SupportsAlpn))]
         [InlineData(SettingId.MaxFrameSize, 16383)]
         [InlineData(SettingId.MaxFrameSize, 162777216)]