diff --git a/src/libraries/Common/tests/System/Net/Http/HttpClientHandlerTest.Decompression.cs b/src/libraries/Common/tests/System/Net/Http/HttpClientHandlerTest.Decompression.cs
index 439cadf32ae62..4da9edc2ca214 100644
--- a/src/libraries/Common/tests/System/Net/Http/HttpClientHandlerTest.Decompression.cs
+++ b/src/libraries/Common/tests/System/Net/Http/HttpClientHandlerTest.Decompression.cs
@@ -28,7 +28,7 @@ public abstract class HttpClientHandler_Decompression_Test : HttpClientHandlerTe
         public HttpClientHandler_Decompression_Test(ITestOutputHelper output) : base(output) { }
 
         public static IEnumerable<object[]> DecompressedResponse_MethodSpecified_DecompressedContentReturned_MemberData() =>
-            from compressionName in new[] { "gzip", "zlib", "deflate", "br" }
+            from compressionName in new[] { "gzip", "GZIP", "zlib", "ZLIB", "deflate", "DEFLATE", "br", "BR" }
             from all in new[] { false, true }
             from copyTo in new[] { false, true }
             from contentLength in new[] { 0, 1, 12345 }
@@ -40,7 +40,7 @@ public static IEnumerable<object[]> DecompressedResponse_MethodSpecified_Decompr
         public async Task DecompressedResponse_MethodSpecified_DecompressedContentReturned(string compressionName, bool all, bool useCopyTo, int contentLength)
         {
             if (IsWinHttpHandler &&
-                (compressionName == "br" || compressionName == "zlib"))
+                (compressionName is "br" or "BR" or "zlib" or "ZLIB"))
             {
                 // brotli and zlib not supported on WinHttpHandler
                 return;
@@ -52,17 +52,20 @@ public async Task DecompressedResponse_MethodSpecified_DecompressedContentReturn
             switch (compressionName)
             {
                 case "gzip":
+                case "GZIP":
                     compress = s => new GZipStream(s, CompressionLevel.Optimal, leaveOpen: true);
                     methods = all ? DecompressionMethods.GZip : _all;
                     break;
 
 #if !NETFRAMEWORK
                 case "br":
+                case "BR":
                     compress = s => new BrotliStream(s, CompressionLevel.Optimal, leaveOpen: true);
                     methods = all ? DecompressionMethods.Brotli : _all;
                     break;
 
                 case "zlib":
+                case "ZLIB":
                     compress = s => new ZLibStream(s, CompressionLevel.Optimal, leaveOpen: true);
                     methods = all ? DecompressionMethods.Deflate : _all;
                     encodingName = "deflate";
@@ -70,6 +73,7 @@ public async Task DecompressedResponse_MethodSpecified_DecompressedContentReturn
 #endif
 
                 case "deflate":
+                case "DEFLATE":
                     compress = s => new DeflateStream(s, CompressionLevel.Optimal, leaveOpen: true);
                     methods = all ? DecompressionMethods.Deflate : _all;
                     break;
diff --git a/src/libraries/System.Net.Http/src/System/Net/Http/SocketsHttpHandler/DecompressionHandler.cs b/src/libraries/System.Net.Http/src/System/Net/Http/SocketsHttpHandler/DecompressionHandler.cs
index 939a29e06f393..1ea55ac07f614 100644
--- a/src/libraries/System.Net.Http/src/System/Net/Http/SocketsHttpHandler/DecompressionHandler.cs
+++ b/src/libraries/System.Net.Http/src/System/Net/Http/SocketsHttpHandler/DecompressionHandler.cs
@@ -78,15 +78,15 @@ internal override async ValueTask<HttpResponseMessage> SendAsync(HttpRequestMess
                     last = encoding;
                 }
 
-                if (GZipEnabled && last == Gzip)
+                if (GZipEnabled && string.Equals(last, Gzip, StringComparison.OrdinalIgnoreCase))
                 {
                     response.Content = new GZipDecompressedContent(response.Content);
                 }
-                else if (DeflateEnabled && last == Deflate)
+                else if (DeflateEnabled && string.Equals(last, Deflate, StringComparison.OrdinalIgnoreCase))
                 {
                     response.Content = new DeflateDecompressedContent(response.Content);
                 }
-                else if (BrotliEnabled && last == Brotli)
+                else if (BrotliEnabled && string.Equals(last, Brotli, StringComparison.OrdinalIgnoreCase))
                 {
                     response.Content = new BrotliDecompressedContent(response.Content);
                 }