diff --git a/src/System.Windows.Forms/src/System/Windows/Forms/TabControl.cs b/src/System.Windows.Forms/src/System/Windows/Forms/TabControl.cs
index 67b977bff87..2e4aca11f23 100644
--- a/src/System.Windows.Forms/src/System/Windows/Forms/TabControl.cs
+++ b/src/System.Windows.Forms/src/System/Windows/Forms/TabControl.cs
@@ -1970,7 +1970,14 @@ private bool WmSelChange()
             if (IsAccessibilityObjectCreated && SelectedTab?.ParentInternal is TabControl)
             {
                 SelectedTab.TabAccessibilityObject.RaiseAutomationEvent(UiaCore.UIA.SelectionItem_ElementSelectedEventId);
-                BeginInvoke((MethodInvoker)(() => SelectedTab.TabAccessibilityObject.RaiseAutomationEvent(UiaCore.UIA.AutomationFocusChangedEventId)));
+                BeginInvoke((MethodInvoker)(() =>
+                {
+                    if (IsAccessibilityObjectCreated && SelectedTab?.ParentInternal is TabControl &&
+                         !SelectedTab.IsDisposed && SelectedTab.TabAccessibilityObject is not null)
+                    {
+                        SelectedTab.TabAccessibilityObject.RaiseAutomationEvent(UiaCore.UIA.AutomationFocusChangedEventId);
+                    }
+                }));
             }
         }
         else
diff --git a/src/System.Windows.Forms/tests/UnitTests/System/Windows/Forms/TabControlTests.cs b/src/System.Windows.Forms/tests/UnitTests/System/Windows/Forms/TabControlTests.cs
index c3d1ba4eda4..8b32a1ea048 100644
--- a/src/System.Windows.Forms/tests/UnitTests/System/Windows/Forms/TabControlTests.cs
+++ b/src/System.Windows.Forms/tests/UnitTests/System/Windows/Forms/TabControlTests.cs
@@ -5704,6 +5704,40 @@ public void TabControl_Invokes_SetToolTip_IfExternalToolTipIsSet()
         Assert.Equal(text, actual);
     }
 
+    [WinFormsFact]
+    public void TabControl_WmSelChange_SelectedTabIsNull_DoesNotThrowException()
+    {
+        using Form form = new();
+        using TabControl control = new();
+        using TabPage page1 = new("text1");
+        control.TabPages.Add(page1);
+        _ = control.AccessibilityObject;
+
+        form.Controls.Add(control);
+        form.Show();
+        control.SelectedIndex = 0;
+
+        Action act = () => control.TestAccessor().Dynamic.WmSelChange();
+        try
+        {
+            act();
+        }
+        catch (Exception ex)
+        {
+            Assert.Fail($"Expected no exception, but got: {ex}");
+        }
+
+        control.TabPages.Clear();
+
+        var exception = Record.Exception(() =>
+        {
+            Application.DoEvents();
+            Thread.Sleep(100);
+        });
+
+        Assert.Null(exception);
+    }
+
     private class SubTabPage : TabPage
     {
     }