diff --git a/x-pack/plugins/apm/public/components/app/profiling_overview/profiling_flamegraph.tsx b/x-pack/plugins/apm/public/components/app/profiling_overview/profiling_flamegraph.tsx
index 2df8eb2e28c8b..3db934039a769 100644
--- a/x-pack/plugins/apm/public/components/app/profiling_overview/profiling_flamegraph.tsx
+++ b/x-pack/plugins/apm/public/components/app/profiling_overview/profiling_flamegraph.tsx
@@ -5,17 +5,28 @@
  * 2.0.
  */
 
-import { EuiFlexGroup, EuiFlexItem, EuiLink, EuiSpacer } from '@elastic/eui';
+import {
+  EuiEmptyPrompt,
+  EuiFlexGroup,
+  EuiFlexItem,
+  EuiLink,
+  EuiSpacer,
+} from '@elastic/eui';
 import { i18n } from '@kbn/i18n';
 import { EmbeddableFlamegraph } from '@kbn/observability-shared-plugin/public';
+import { isEmpty } from 'lodash';
 import React from 'react';
+import { ApmDataSourceWithSummary } from '../../../../common/data_source';
+import { ApmDocumentType } from '../../../../common/document_type';
 import { HOST_NAME } from '../../../../common/es_fields/apm';
 import { toKueryFilterFormat } from '../../../../common/utils/to_kuery_filter_format';
-import { isPending, useFetcher } from '../../../hooks/use_fetcher';
+import {
+  FETCH_STATUS,
+  isPending,
+  useFetcher,
+} from '../../../hooks/use_fetcher';
 import { useProfilingPlugin } from '../../../hooks/use_profiling_plugin';
 import { HostnamesFilterWarning } from './host_names_filter_warning';
-import { ApmDataSourceWithSummary } from '../../../../common/data_source';
-import { ApmDocumentType } from '../../../../common/document_type';
 
 interface Props {
   serviceName: string;
@@ -86,11 +97,24 @@ export function ProfilingFlamegraph({
         </EuiFlexItem>
       </EuiFlexGroup>
       <EuiSpacer />
-      <EmbeddableFlamegraph
-        data={data?.flamegraph}
-        isLoading={isPending(status)}
-        height="60vh"
-      />
+      {status === FETCH_STATUS.SUCCESS && isEmpty(data) ? (
+        <EuiEmptyPrompt
+          titleSize="s"
+          title={
+            <div>
+              {i18n.translate('xpack.apm.profiling.flamegraph.noDataFound', {
+                defaultMessage: 'No data found',
+              })}
+            </div>
+          }
+        />
+      ) : (
+        <EmbeddableFlamegraph
+          data={data?.flamegraph}
+          isLoading={isPending(status)}
+          height="60vh"
+        />
+      )}
     </>
   );
 }
diff --git a/x-pack/plugins/apm/public/components/routing/templates/apm_service_template/index.tsx b/x-pack/plugins/apm/public/components/routing/templates/apm_service_template/index.tsx
index c797550c1617a..2e97a0e6156c5 100644
--- a/x-pack/plugins/apm/public/components/routing/templates/apm_service_template/index.tsx
+++ b/x-pack/plugins/apm/public/components/routing/templates/apm_service_template/index.tsx
@@ -27,6 +27,7 @@ import {
   isAWSLambdaAgent,
   isAzureFunctionsAgent,
   isServerlessAgent,
+  isRumOrMobileAgent,
 } from '../../../../../common/agent_name';
 import { useApmPluginContext } from '../../../../context/apm_plugin/use_apm_plugin_context';
 import { ApmServiceContextProvider } from '../../../../context/apm_service/apm_service_context';
@@ -404,7 +405,10 @@ function useTabs({ selectedTab }: { selectedTab: Tab['key'] }) {
       label: i18n.translate('xpack.apm.home.profilingTabLabel', {
         defaultMessage: 'Universal Profiling',
       }),
-      hidden: !isProfilingAvailable,
+      hidden:
+        !isProfilingAvailable ||
+        isRumOrMobileAgent(agentName) ||
+        isAWSLambdaAgent(serverlessType),
       append: (
         <EuiBadge color="accent">
           {i18n.translate('xpack.apm.universalProfiling.newLabel', {
diff --git a/x-pack/plugins/apm/server/routes/profiling/route.ts b/x-pack/plugins/apm/server/routes/profiling/route.ts
index 78c605cb2f457..b3e0a78ea5f2d 100644
--- a/x-pack/plugins/apm/server/routes/profiling/route.ts
+++ b/x-pack/plugins/apm/server/routes/profiling/route.ts
@@ -57,6 +57,10 @@ const profilingFlamegraphRoute = createApmServerRoute({
         rollupInterval,
       });
 
+      if (!serviceHostNames.length) {
+        return undefined;
+      }
+
       const flamegraph =
         await profilingDataAccessStart?.services.fetchFlamechartData({
           esClient: esClient.asCurrentUser,
@@ -116,6 +120,10 @@ const profilingFunctionsRoute = createApmServerRoute({
         rollupInterval,
       });
 
+      if (!serviceHostNames.length) {
+        return undefined;
+      }
+
       const functions = await profilingDataAccessStart?.services.fetchFunction({
         esClient: esClient.asCurrentUser,
         rangeFromMs: start,